OKAMURA DAIJI 岡村大治

… Alternative Names

Okamura Daiji 岡村大治

OKAMURA Daiji 岡村大治

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Researcher Number	80393263
Other IDs
Affiliation (Current)	2025: 近畿大学, 農学部, 准教授
Affiliation (based on the past Project Information) *help	2015 – 2024: 近畿大学, 農学部, 講師 2012: 東北大学, 加齢医学研究所, 助教 2007 – 2009: Tohoku University, 加齢医学研究所, 助教 2006: 東北大学, 加齢医学研究所, 助手
Review Section/Research Field	Principal Investigator Developmental biology / Basic Section 44020:Developmental biology-related / Cell biology Except Principal Investigator Basic Section 42030:Animal life science-related / Biological Sciences
Keywords	Principal Investigator 始原生殖細胞 / マウス / 遺伝子プロファイル / EG細胞 / 多能性 / 分化決定 / 未分化細胞 / 再生医療 / 心筋誘導 / 細胞分裂 … More / コレステロール生合成阻害剤 / 細胞死 / ドーパミン作動性ニューロン / 未分化 / アポトーシス / コレステロール生合成 / 腫瘍原性 / ヒトiPS細胞 / 新規多能性幹細胞 / Primordial Germ Cells / エピジェネティクス / キメラ形成 / シグナル伝達阻害剤 / メチル化 / ビタミンC / 多能性幹細胞 / 再プログラム化 / エピジェネティック / RNAシークエンス / vcPGC細胞 / PGCs / ES細胞 / 相同組み替え / Rest / 転写抑制因子 / 4 / Oct3 / 転写抑制 / 遺伝子欠損マウス / 生殖細胞 / 分化 / 機能解析 / 遺伝子スクリーニング … More Except Principal Investigator 体細胞核移植 / 受精卵 / 脱アセチル化酵素阻害剤 / クロマチンリモデリング / ヒストンH2A.Z / ES細胞 / HDAC阻害剤 / 質量分析 / リプログラミング / ヒストン脱アセチル化酵素阻害剤 / 全能性獲得 / 受精 / 異種 / 胚性幹細胞 / 顕微授精 / FISH解析 / FISH / ハイブリッド胚 / 雄性2倍体胚 / Vasa / 転写制御 / DNAメチル化 / siRNA / 遺伝子改変マウス / エピジェネティクス / 始原生殖細胞 Less

The mechanism of removal of histone H2A variants in fertilized eggs and development of reprogramming assistance technique
- Principal Investigator
  
  三谷匡
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  Kindai University
Study on the mechanism of histone H2A.Z remodeling and development of a novel reprogramming technology
- Principal Investigator
  
  MITANI Tasuku
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  Kindai University
The technology to eliminate the risk of tumor formation in human iPS cells by inhibiting cholesterol biosynthesis.Principal Investigator
- Principal Investigator
  
  Okamura Daiji
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44020:Developmental biology-related
- Research Institution
  Kindai University
Establishment of ES cells derived from androgenic diploid embryos produced by interspecific sperm injection and induction of gametogenesis
- Principal Investigator
  
  Mitani Tasuku
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  Kindai University
Epigenetic modifications for reprogramming and chimeric competency of cells.Principal Investigator
- Principal Investigator
  
  Okamura Daiji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Developmental biology
- Research Institution
  Kindai University
エピジェネティック修飾による新規多能性幹細胞の樹立機構の解明Principal Investigator
- Principal Investigator
  
  岡村大治
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Cell biology
- Research Institution
  Kinki University
Gene networks regulating development of primordial germ cells
- Principal Investigator
  
  MATSUI Yasuhisa (YASUHISA Matsui)
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Elucidation of systems for mouse PGC specification regulated by pluripotent-associatedgene Oct3/4Principal Investigator
- Principal Investigator
  
  OKAMURA Daiji
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Developmental biology
- Research Institution
  Tohoku University
マウス始原生殖細胞の分化決定システムとその制御因子群の解明Principal Investigator
- Principal Investigator
  
  岡村大治
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Developmental biology
- Research Institution
  Tohoku University

All 2022 2021 2018 2017 2013 2012 2011 2010 2009 2008

All Journal Article Presentation

[Journal Article] The amount of membrane cholesterol required for robust cell adhesion and proliferation in serum-free condition2022
- Author(s)
  Takii Shino、Wu Jun、Okamura Daiji
- Journal Title
  
  PLOS ONE
  
  Volume: 17 Issue: 7 Pages: e0259482-e0259482
- DOI
  10.1371/journal.pone.0259482
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06661
[Journal Article] Cell competition constitutes a barrier for interspecies chimerism2021
- Author(s)
  Zheng Canbin、Hu Yingying、Sakurai Masahiro、Pinzon-Arteaga Carlos A.、Li Jie、Wei Yulei、Okamura Daiji、Ravaux Benjamin、Barlow Haley Rose、Yu Leqian、Sun Hai-Xi、Chen Elizabeth H.、Gu Ying、Wu Jun
- Journal Title
  
  Nature
  
  Volume: 592 Issue: 7853 Pages: 272-276
- DOI
  10.1038/s41586-021-03273-0
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06661
[Journal Article] Derivation of Intermediate Pluripotent Stem Cells Amenable to Primordial Germ Cell Specification2021
- Author(s)
  Yu Leqian、Wei Yulei、Sun Hai-Xi、Mahdi Ahmed K.、Pinzon Arteaga Carlos A.、Sakurai Masahiro、Schmitz Daniel A.、Zheng Canbin、Ballard Emily D.、Li Jie、Tanaka Noriko、Kohara Aoi、Okamura Daiji、Mutto Adrian A.、Gu Ying、Ross Pablo J.、Wu Jun
- Journal Title
  
  Cell Stem Cell
  
  Volume: 28 Issue: 3 Pages: 550-567.e12
- DOI
  10.1016/j.stem.2020.11.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06661
[Journal Article] Stepwise conversion methods between ground states pluripotency from naive to primed.2021
- Author(s)
  Okamura D, Chikushi M, Chigi Y, Shiogai N, Jafar S, Wu J.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 574 Pages: 70-77
- DOI
  10.1016/j.bbrc.2021.07.097
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06661
[Journal Article] Efficient derivation of stable primed pluripotent embryonic stem cells from bovine blastocysts2018
- Author(s)
  Bogliotti Yanina Soledad、Wu Jun、Vilarino Marcela、Okamura Daiji、Soto Delia Alba、Zhong Cuiqing、Sakurai Masahiro、Sampaio Rafael Vilar、Suzuki Keiichiro、Izpisua Belmonte Juan Carlos、Ross Pablo Juan
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 115 Issue: 9 Pages: 2090-2095
- DOI
  10.1073/pnas.1716161115
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04796
[Journal Article] Derivation of pluripotent stem cells from nascent undifferentiated teratoma.2018
- Author(s)
  An Y, Sekinaka T, Tando Y, Okamura D, Tanaka K, Ito-Matsuoka Y, Takehara A, Yaegashi N, Matsui Y.
- Journal Title
  
  Developmental Biology
  
  Volume: 446 Issue: 1 Pages: 43-55
- DOI
  10.1016/j.ydbio.2018.11.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15001, KAKENHI-PROJECT-16H04796, KAKENHI-PROJECT-17J02039
[Journal Article] Interspecies Chimerism with Mammalian Pluripotent Stem Cells.2017
- Author(s)
  Wu J, Platero-Luengo A, Sakurai M, Sugawara A, Gil MA, Yamauchi T, Suzuki K, Bogliotti YS, Cuello C, Morales Valencia M, Okamura D, Luo J, Hishida T, Maga EA, Esteban CR, Berggren WT, Lajara J, Guillen I, Guillen P, Campistol JM, Martinez EA, Ross PJ, Izpisua Belmonte JC.
- Journal Title
  
  Cell
  
  Volume: 168 Issue: 3 Pages: 473-486
- DOI
  10.1016/j.cell.2016.12.036
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04796
[Journal Article] CRISPR-Cas9 mediated one-step disabling of pancreatogenesis in pigs2017
- Author(s)
  Wu Jun、Vilarino Marcela、Suzuki Keiichiro、Okamura Daiji、Bogliotti Yanina Soledad、Park Insung、Rowe Joan、McNabb Bret、Ross Pablo Juan、Belmonte Juan Carlos Izpisua
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 10487-10493
- DOI
  10.1038/s41598-017-08596-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04796
[Journal Article] Max is a repressor of germ-cell-related gene expression in mouse embryonic stem cells2013
- Author(s)
  Maeda, I., Okamura, D., Tokitake, Y., Ikeda, M, Kawaguchi, H., Mise, N., Abe, K., Noce, T., Okuda, A, Matsui, Y
- Journal Title
  
  Nature Communications
  
  Volume: 4 Issue: 1 Pages: 1754-1754
- DOI
  10.1038/ncomms2780
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062001, KAKENHI-PLANNED-20062013, KAKENHI-PROJECT-22590275, KAKENHI-PROJECT-23651189, KAKENHI-PLANNED-25114003, KAKENHI-PROJECT-25293082, KAKENHI-PROJECT-25450474, KAKENHI-PROJECT-25670147
[Journal Article] REST and its downstream molecule Mek5 regulate survival of primordial germ cells.2012
- Author(s)
  Okamura, D
- Journal Title
  
  Developmental Biology
  
  Volume: 372 Pages: 190-202
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062001
[Journal Article] REST and its downstream molecule Mek5 regulate survival of primordial germ cells2012
- Author(s)
  Okamura, D., Mochizuki, K., Taniguchi, H., Tokitake, Y., Ikeda, M., Yamada, Y., Tournier, C., Yamaguchi, S., Tada, T., Scholer, H.R. and Matsui, Y
- Journal Title
  
  Developmental Biology
  
  Volume: 372 Pages: 190-202
- URL
  http://dx.doi.org/10.1016/j.ydbio.2012.09.013
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062001
[Journal Article] Cell-cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells2012
- Author(s)
  Okamura, D., Maeda, I., Taniguchi, H., Tokitake, Y., Ikeda, M., Ozato, K., Mise, N., Abe, K., Noce, T., Izpisua Belmonte, J. C. and Matsui, Y
- Journal Title
  
  Genes & Development
  
  Volume: 26 Issue: 22 Pages: 2477-2482
- DOI
  10.1101/gad.202242.112
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062001, KAKENHI-PLANNED-20062013, KAKENHI-PROJECT-23651189
[Journal Article] Requirement of Oct3/4 function for germ cell specification2008
- Author(s)
  Okamura, et. al.
- Journal Title
  
  Developmental Biology (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18770192
[Journal Article] Requirement of Oct3/4 function for germ cell specification.2008
- Author(s)
  D. Okamura, Y. Tokitake, H. Niwa, Y. Matsui.
- Journal Title
  
  Dev Biol. 317(2)
  
  Pages: 576-584
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770170
[Journal Article] Requirement of Oct3/4 for germ cell specification.2008
- Author(s)
  Okamura, D
- Journal Title
  
  Developmental Biology 317
  
  Pages: 576-584
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062001
[Journal Article] Requirement of Oct3/4 for germ cell specification.2008
- Author(s)
  Okamura, D., Tokitake, Y., Niwa, H., Matsui, Y.
- Journal Title
  
  Dev.Biol. 317
  
  Pages: 576-584
- Data Source
  KAKENHI-PLANNED-20062001
[Journal Article] Requirement of Oct3/4 for germ cell specification2008
- Author(s)
  Okamura, D., Tokitake, Y., Niwa, H., and Matsui, Y
- Journal Title
  
  Developmental Biolology
  
  Volume: 317 Issue: 2 Pages: 576-584
- DOI
  10.1016/j.ydbio.2008.03.002
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062001
[Journal Article] Requirement of Oct3/4 function for germ cell specification2008
- Author(s)
  Okamura et.al.
- Journal Title
  
  Developmental Biology 312(2)
  
  Pages: 576-584
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770170
[Presentation] Development of a universal serum-free medium for cancer cell lines by regulation of cholesterol metabolism.2021
- Author(s)
  滝井詩乃, 岡村大治
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-20K06661
[Presentation] 多能性幹細胞のエネルギー代謝による制御2018
- Author(s)
  岡村大治, 田中法子, 佐渡敬
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16H04796
[Presentation] マウス始原生殖細胞の生存・増殖に関わる分子機構の解明2011
- Author(s)
  岡村大治、谷口大史、時武裕子、山田泰広、松居靖久
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PLANNED-20062001
[Presentation] 転写活性化因子Larp7による始原生殖細胞の増殖制御機構2011
- Author(s)
  松居靖久、前田郁麻、岡村大治
- Organizer
  文部科学省科学研究費補助金特定領域研究「生殖細胞の世代サイクルとエピゲノムネットワーク」による公開シンポジウム
- Place of Presentation
  大阪
- Year and Date
  2011-11-17
- Data Source
  KAKENHI-PLANNED-20062001
[Presentation] Functions of REST and Larp7 on survival and proliferation of primordial germ cells in mouse2011
- Author(s)
  Y. Matsui and D. Okamura
- Organizer
  Cold Spring Harbor Asia Meeting,'Developmental Control of Sex Growth and Cellular Fate
- Place of Presentation
  Shzou, China
- Year and Date
  2011-10-12
- Data Source
  KAKENHI-PLANNED-20062001
[Presentation] Functions of an epigenetic modulator, REST for survival of primordial germ cells2011
- Author(s)
  D. Okamura, H. Taniguchi, Y. Tokitake, Y. Yamada and Y. Matsui
- Organizer
  Keystone Symposium 'Stem Cells, Cancer and Metastasis'
- Place of Presentation
  Keystone, Colorado, USA
- Data Source
  KAKENHI-PLANNED-20062001
[Presentation] 多能性関連分子が制御するマウス始原生殖細胞の分化決定システムの解明2010
- Author(s)
  岡村大治, その他
- Organizer
  シンポジウム「仙台・動物発生コロキウム」
- Place of Presentation
  仙台・東北大学
- Year and Date
  2010-01-22
- Data Source
  KAKENHI-PROJECT-20770170
[Presentation] 多能性関連分子が制御するマウス始原生殖細胞の分化決定システムの解明2010
- Author(s)
  岡村大治, その他
- Organizer
  シンポジウム「仙台・動物発生コロキウム」
- Place of Presentation
  仙台・東北大学萩ホール
- Year and Date
  2010-01-22
- Data Source
  KAKENHI-PROJECT-20770170
[Presentation] Functions of an epigenetic regulator, REST for survival of primordial germ cells2010
- Author(s)
  D. Okamura and Y. Matsui
- Organizer
  International Symposium on 'Epigenome Network, Development and Reprogramming of Germ Cells'
- Place of Presentation
  Fukuoka, Japan
- Data Source
  KAKENHI-PLANNED-20062001
[Presentation] Epigenetic mechanisms underlying germ cell formation and their survival2010
- Author(s)
  Y. Matsui, K. Mochizuki and D. Okamura
- Organizer
  International Symposium on 'Epigenome Network, Development and Reprogramming of Germ Cells'
- Place of Presentation
  Fukuoka , Japan
- Data Source
  KAKENHI-PLANNED-20062001
[Presentation] 多能性関連分子が制御するマウス始原生殖細胞の分化決定システムの解明2009
- Author(s)
  岡村大治、時武裕子、谷口大史、松居靖久
- Organizer
  文部科学省科学研究費補助金特定領域研究「生殖細胞の世代サイクルとエピゲノムネットワーク」による公開シンポジウム
- Place of Presentation
  東京
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PLANNED-20062001
[Presentation] Requirement of Oct3/4 function for germ cell specification.2008
- Author(s)
  Okamura, D
- Organizer
  Joint meeting of the societe Francaise de Biologie du Development/Japanese Society of Developmental Biologists, 'Frontiers in Developmental Biology'
- Place of Presentation
  Presqu'ile de Giens, France
- Data Source
  KAKENHI-PLANNED-20062001
[Presentation] Requirement of Oct3/4 function for germ cell specification2008
- Author(s)
  D. Okamura, Y. Tokitake, H. Niwa and Y. Matsui
- Organizer
  Joint meeting of the societe Francaise de Biologie du Development /Japanese Society of Developmental Biologists, 'Frontiers in Developmental Biology'
- Place of Presentation
  Presqu'ile de Giens, France
- Data Source
  KAKENHI-PLANNED-20062001
[Presentation] Requirement of Oct3/4 function for germ cell specification2008
- Author(s)
  Okamura et.al.
- Organizer
  Frontiers in Developmental Biology
- Place of Presentation
  Giens, Southern France
- Data Source
  KAKENHI-PROJECT-20770170
[Presentation] Frontiers in Developmental Biology2008
- Author(s)
  Okamura, et al.
- Organizer
  Requirement of Oct3/4 function for germ cell specification.
- Place of Presentation
  Giens, Southern France
- Data Source
  KAKENHI-PROJECT-20770170

1. Mitani Tasuku (10322265)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. 田辺秀之 (50261178)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. MAEDA Ikuma (20376560)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. MATSUI Yasuhisa (40241575)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
5. NOCE Toshiaki (70183902)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 丹藤由希子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OKAMURA DAIJI 岡村 大治

Okamura Daiji 岡村 大治

OKAMURA Daiji 岡村 大治

Research Projects

Research Products

Co-Researchers

The mechanism of removal of histone H2A variants in fertilized eggs and development of reprogramming assistance technique

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study on the mechanism of histone H2A.Z remodeling and development of a novel reprogramming technology

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The technology to eliminate the risk of tumor formation in human iPS cells by inhibiting cholesterol biosynthesis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of ES cells derived from androgenic diploid embryos produced by interspecific sperm injection and induction of gametogenesis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Epigenetic modifications for reprogramming and chimeric competency of cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

エピジェネティック修飾による新規多能性幹細胞の樹立機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Gene networks regulating development of primordial germ cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of systems for mouse PGC specification regulated by pluripotent-associatedgene Oct3/4Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

マウス始原生殖細胞の分化決定システムとその制御因子群の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The amount of membrane cholesterol required for robust cell adhesion and proliferation in serum-free condition2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cell competition constitutes a barrier for interspecies chimerism2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Derivation of Intermediate Pluripotent Stem Cells Amenable to Primordial Germ Cell Specification2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Stepwise conversion methods between ground states pluripotency from naive to primed.2021

Author(s)

Journal Title

DOI

Data Source

OKAMURA DAIJI 岡村大治

Okamura Daiji 岡村大治

OKAMURA Daiji 岡村大治