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OKAMURA DAIJI  岡村 大治

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Okamura Daiji  岡村 大治

OKAMURA Daiji  岡村 大治

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Researcher Number 80393263
Other IDs
Affiliation (Current) 2025: 近畿大学, 農学部, 准教授
Affiliation (based on the past Project Information) *help 2015 – 2024: 近畿大学, 農学部, 講師
2012: 東北大学, 加齢医学研究所, 助教
2007 – 2009: Tohoku University, 加齢医学研究所, 助教
2006: 東北大学, 加齢医学研究所, 助手
Review Section/Research Field
Principal Investigator
Developmental biology / Basic Section 44020:Developmental biology-related / Cell biology
Except Principal Investigator
Basic Section 42030:Animal life science-related / Biological Sciences
Keywords
Principal Investigator
始原生殖細胞 / マウス / 遺伝子プロファイル / EG細胞 / 多能性 / 分化決定 / 未分化細胞 / 再生医療 / 心筋誘導 / 細胞分裂 … More / コレステロール生合成阻害剤 / 細胞死 / ドーパミン作動性ニューロン / 未分化 / アポトーシス / コレステロール生合成 / 腫瘍原性 / ヒトiPS細胞 / 新規多能性幹細胞 / Primordial Germ Cells / エピジェネティクス / キメラ形成 / シグナル伝達阻害剤 / メチル化 / ビタミンC / 多能性幹細胞 / 再プログラム化 / エピジェネティック / RNAシークエンス / vcPGC細胞 / PGCs / ES細胞 / 相同組み替え / Rest / 転写抑制因子 / 4 / Oct3 / 転写抑制 / 遺伝子欠損マウス / 生殖細胞 / 分化 / 機能解析 / 遺伝子スクリーニング … More
Except Principal Investigator
体細胞核移植 / 受精卵 / 脱アセチル化酵素阻害剤 / クロマチンリモデリング / ヒストンH2A.Z / ES細胞 / HDAC阻害剤 / 質量分析 / リプログラミング / ヒストン脱アセチル化酵素阻害剤 / 全能性獲得 / 受精 / 異種 / 胚性幹細胞 / 顕微授精 / FISH解析 / FISH / ハイブリッド胚 / 雄性2倍体胚 / Vasa / 転写制御 / DNAメチル化 / siRNA / 遺伝子改変マウス / エピジェネティクス / 始原生殖細胞 Less
  • Research Projects

    (9 results)
  • Research Products

    (33 results)
  • Co-Researchers

    (6 People)
  •  The mechanism of removal of histone H2A variants in fertilized eggs and development of reprogramming assistance technique

    • Principal Investigator
      三谷 匡
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 42030:Animal life science-related
    • Research Institution
      Kindai University
  •  Study on the mechanism of histone H2A.Z remodeling and development of a novel reprogramming technology

    • Principal Investigator
      MITANI Tasuku
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 42030:Animal life science-related
    • Research Institution
      Kindai University
  •  The technology to eliminate the risk of tumor formation in human iPS cells by inhibiting cholesterol biosynthesis.Principal Investigator

    • Principal Investigator
      Okamura Daiji
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 44020:Developmental biology-related
    • Research Institution
      Kindai University
  •  Establishment of ES cells derived from androgenic diploid embryos produced by interspecific sperm injection and induction of gametogenesis

    • Principal Investigator
      Mitani Tasuku
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 42030:Animal life science-related
    • Research Institution
      Kindai University
  •  Epigenetic modifications for reprogramming and chimeric competency of cells.Principal Investigator

    • Principal Investigator
      Okamura Daiji
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Developmental biology
    • Research Institution
      Kindai University
  •  エピジェネティック修飾による新規多能性幹細胞の樹立機構の解明Principal Investigator

    • Principal Investigator
      岡村 大治
    • Project Period (FY)
      2015
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Cell biology
    • Research Institution
      Kinki University
  •  Gene networks regulating development of primordial germ cells

    • Principal Investigator
      MATSUI Yasuhisa (YASUHISA Matsui)
    • Project Period (FY)
      2008 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University
  •  Elucidation of systems for mouse PGC specification regulated by pluripotent-associatedgene Oct3/4Principal Investigator

    • Principal Investigator
      OKAMURA Daiji
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Developmental biology
    • Research Institution
      Tohoku University
  •  マウス始原生殖細胞の分化決定システムとその制御因子群の解明Principal Investigator

    • Principal Investigator
      岡村 大治
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Developmental biology
    • Research Institution
      Tohoku University

All 2022 2021 2018 2017 2013 2012 2011 2010 2009 2008

All Journal Article Presentation

  • [Journal Article] The amount of membrane cholesterol required for robust cell adhesion and proliferation in serum-free condition2022

    • Author(s)
      Takii Shino、Wu Jun、Okamura Daiji
    • Journal Title

      PLOS ONE

      Volume: 17 Issue: 7 Pages: e0259482-e0259482

    • DOI

      10.1371/journal.pone.0259482

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K06661
  • [Journal Article] Cell competition constitutes a barrier for interspecies chimerism2021

    • Author(s)
      Zheng Canbin、Hu Yingying、Sakurai Masahiro、Pinzon-Arteaga Carlos A.、Li Jie、Wei Yulei、Okamura Daiji、Ravaux Benjamin、Barlow Haley Rose、Yu Leqian、Sun Hai-Xi、Chen Elizabeth H.、Gu Ying、Wu Jun
    • Journal Title

      Nature

      Volume: 592 Issue: 7853 Pages: 272-276

    • DOI

      10.1038/s41586-021-03273-0

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K06661
  • [Journal Article] Derivation of Intermediate Pluripotent Stem Cells Amenable to Primordial Germ Cell Specification2021

    • Author(s)
      Yu Leqian、Wei Yulei、Sun Hai-Xi、Mahdi Ahmed K.、Pinzon Arteaga Carlos A.、Sakurai Masahiro、Schmitz Daniel A.、Zheng Canbin、Ballard Emily D.、Li Jie、Tanaka Noriko、Kohara Aoi、Okamura Daiji、Mutto Adrian A.、Gu Ying、Ross Pablo J.、Wu Jun
    • Journal Title

      Cell Stem Cell

      Volume: 28 Issue: 3 Pages: 550-567.e12

    • DOI

      10.1016/j.stem.2020.11.003

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K06661
  • [Journal Article] Stepwise conversion methods between ground states pluripotency from naive to primed.2021

    • Author(s)
      Okamura D, Chikushi M, Chigi Y, Shiogai N, Jafar S, Wu J.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 574 Pages: 70-77

    • DOI

      10.1016/j.bbrc.2021.07.097

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K06661
  • [Journal Article] Efficient derivation of stable primed pluripotent embryonic stem cells from bovine blastocysts2018

    • Author(s)
      Bogliotti Yanina Soledad、Wu Jun、Vilarino Marcela、Okamura Daiji、Soto Delia Alba、Zhong Cuiqing、Sakurai Masahiro、Sampaio Rafael Vilar、Suzuki Keiichiro、Izpisua Belmonte Juan Carlos、Ross Pablo Juan
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 115 Issue: 9 Pages: 2090-2095

    • DOI

      10.1073/pnas.1716161115

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H04796
  • [Journal Article] Derivation of pluripotent stem cells from nascent undifferentiated teratoma.2018

    • Author(s)
      An Y, Sekinaka T, Tando Y, Okamura D, Tanaka K, Ito-Matsuoka Y, Takehara A, Yaegashi N, Matsui Y.
    • Journal Title

      Developmental Biology

      Volume: 446 Issue: 1 Pages: 43-55

    • DOI

      10.1016/j.ydbio.2018.11.020

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K15001, KAKENHI-PROJECT-16H04796, KAKENHI-PROJECT-17J02039
  • [Journal Article] Interspecies Chimerism with Mammalian Pluripotent Stem Cells.2017

    • Author(s)
      Wu J, Platero-Luengo A, Sakurai M, Sugawara A, Gil MA, Yamauchi T, Suzuki K, Bogliotti YS, Cuello C, Morales Valencia M, Okamura D, Luo J, Hishida T, Maga EA, Esteban CR, Berggren WT, Lajara J, Guillen I, Guillen P, Campistol JM, Martinez EA, Ross PJ, Izpisua Belmonte JC.
    • Journal Title

      Cell

      Volume: 168 Issue: 3 Pages: 473-486

    • DOI

      10.1016/j.cell.2016.12.036

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H04796
  • [Journal Article] CRISPR-Cas9 mediated one-step disabling of pancreatogenesis in pigs2017

    • Author(s)
      Wu Jun、Vilarino Marcela、Suzuki Keiichiro、Okamura Daiji、Bogliotti Yanina Soledad、Park Insung、Rowe Joan、McNabb Bret、Ross Pablo Juan、Belmonte Juan Carlos Izpisua
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 10487-10493

    • DOI

      10.1038/s41598-017-08596-5

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H04796
  • [Journal Article] Max is a repressor of germ-cell-related gene expression in mouse embryonic stem cells2013

    • Author(s)
      Maeda, I., Okamura, D., Tokitake, Y., Ikeda, M, Kawaguchi, H., Mise, N., Abe, K., Noce, T., Okuda, A, Matsui, Y
    • Journal Title

      Nature Communications

      Volume: 4 Issue: 1 Pages: 1754-1754

    • DOI

      10.1038/ncomms2780

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20062001, KAKENHI-PLANNED-20062013, KAKENHI-PROJECT-22590275, KAKENHI-PROJECT-23651189, KAKENHI-PLANNED-25114003, KAKENHI-PROJECT-25293082, KAKENHI-PROJECT-25450474, KAKENHI-PROJECT-25670147
  • [Journal Article] REST and its downstream molecule Mek5 regulate survival of primordial germ cells.2012

    • Author(s)
      Okamura, D
    • Journal Title

      Developmental Biology

      Volume: 372 Pages: 190-202

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20062001
  • [Journal Article] REST and its downstream molecule Mek5 regulate survival of primordial germ cells2012

    • Author(s)
      Okamura, D., Mochizuki, K., Taniguchi, H., Tokitake, Y., Ikeda, M., Yamada, Y., Tournier, C., Yamaguchi, S., Tada, T., Scholer, H.R. and Matsui, Y
    • Journal Title

      Developmental Biology

      Volume: 372 Pages: 190-202

    • URL

      http://dx.doi.org/10.1016/j.ydbio.2012.09.013

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20062001
  • [Journal Article] Cell-cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells2012

    • Author(s)
      Okamura, D., Maeda, I., Taniguchi, H., Tokitake, Y., Ikeda, M., Ozato, K., Mise, N., Abe, K., Noce, T., Izpisua Belmonte, J. C. and Matsui, Y
    • Journal Title

      Genes & Development

      Volume: 26 Issue: 22 Pages: 2477-2482

    • DOI

      10.1101/gad.202242.112

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20062001, KAKENHI-PLANNED-20062013, KAKENHI-PROJECT-23651189
  • [Journal Article] Requirement of Oct3/4 function for germ cell specification2008

    • Author(s)
      Okamura, et. al.
    • Journal Title

      Developmental Biology (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18770192
  • [Journal Article] Requirement of Oct3/4 function for germ cell specification.2008

    • Author(s)
      D. Okamura, Y. Tokitake, H. Niwa, Y. Matsui.
    • Journal Title

      Dev Biol. 317(2)

      Pages: 576-584

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20770170
  • [Journal Article] Requirement of Oct3/4 for germ cell specification.2008

    • Author(s)
      Okamura, D
    • Journal Title

      Developmental Biology 317

      Pages: 576-584

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20062001
  • [Journal Article] Requirement of Oct3/4 for germ cell specification.2008

    • Author(s)
      Okamura, D., Tokitake, Y., Niwa, H., Matsui, Y.
    • Journal Title

      Dev.Biol. 317

      Pages: 576-584

    • Data Source
      KAKENHI-PLANNED-20062001
  • [Journal Article] Requirement of Oct3/4 for germ cell specification2008

    • Author(s)
      Okamura, D., Tokitake, Y., Niwa, H., and Matsui, Y
    • Journal Title

      Developmental Biolology

      Volume: 317 Issue: 2 Pages: 576-584

    • DOI

      10.1016/j.ydbio.2008.03.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20062001
  • [Journal Article] Requirement of Oct3/4 function for germ cell specification2008

    • Author(s)
      Okamura et.al.
    • Journal Title

      Developmental Biology 312(2)

      Pages: 576-584

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20770170
  • [Presentation] Development of a universal serum-free medium for cancer cell lines by regulation of cholesterol metabolism.2021

    • Author(s)
      滝井詩乃, 岡村大治
    • Organizer
      日本癌学会
    • Data Source
      KAKENHI-PROJECT-20K06661
  • [Presentation] 多能性幹細胞のエネルギー代謝による制御2018

    • Author(s)
      岡村 大治, 田中 法子, 佐渡 敬
    • Organizer
      第41回 日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H04796
  • [Presentation] マウス始原生殖細胞の生存・増殖に関わる分子機構の解明2011

    • Author(s)
      岡村大治、谷口大史、時武裕子、山田泰広、松居靖久
    • Organizer
      第34回 日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-13
    • Data Source
      KAKENHI-PLANNED-20062001
  • [Presentation] 転写活性化因子Larp7による始原生殖細胞の増殖制御機構2011

    • Author(s)
      松居靖久、前田郁麻、岡村大治
    • Organizer
      文部科学省科学研究費補助金特定領域研究「生殖細胞の世代サイクルとエピゲノムネットワーク」による公開シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2011-11-17
    • Data Source
      KAKENHI-PLANNED-20062001
  • [Presentation] Functions of REST and Larp7 on survival and proliferation of primordial germ cells in mouse2011

    • Author(s)
      Y. Matsui and D. Okamura
    • Organizer
      Cold Spring Harbor Asia Meeting,'Developmental Control of Sex Growth and Cellular Fate
    • Place of Presentation
      Shzou, China
    • Year and Date
      2011-10-12
    • Data Source
      KAKENHI-PLANNED-20062001
  • [Presentation] Functions of an epigenetic modulator, REST for survival of primordial germ cells2011

    • Author(s)
      D. Okamura, H. Taniguchi, Y. Tokitake, Y. Yamada and Y. Matsui
    • Organizer
      Keystone Symposium 'Stem Cells, Cancer and Metastasis'
    • Place of Presentation
      Keystone, Colorado, USA
    • Data Source
      KAKENHI-PLANNED-20062001
  • [Presentation] 多能性関連分子が制御するマウス始原生殖細胞の分化決定システムの解明2010

    • Author(s)
      岡村大治, その他
    • Organizer
      シンポジウム「仙台・動物発生コロキウム」
    • Place of Presentation
      仙台・東北大学
    • Year and Date
      2010-01-22
    • Data Source
      KAKENHI-PROJECT-20770170
  • [Presentation] 多能性関連分子が制御するマウス始原生殖細胞の分化決定システムの解明2010

    • Author(s)
      岡村大治, その他
    • Organizer
      シンポジウム「仙台・動物発生コロキウム」
    • Place of Presentation
      仙台・東北大学萩ホール
    • Year and Date
      2010-01-22
    • Data Source
      KAKENHI-PROJECT-20770170
  • [Presentation] Functions of an epigenetic regulator, REST for survival of primordial germ cells2010

    • Author(s)
      D. Okamura and Y. Matsui
    • Organizer
      International Symposium on 'Epigenome Network, Development and Reprogramming of Germ Cells'
    • Place of Presentation
      Fukuoka, Japan
    • Data Source
      KAKENHI-PLANNED-20062001
  • [Presentation] Epigenetic mechanisms underlying germ cell formation and their survival2010

    • Author(s)
      Y. Matsui, K. Mochizuki and D. Okamura
    • Organizer
      International Symposium on 'Epigenome Network, Development and Reprogramming of Germ Cells'
    • Place of Presentation
      Fukuoka , Japan
    • Data Source
      KAKENHI-PLANNED-20062001
  • [Presentation] 多能性関連分子が制御するマウス始原生殖細胞の分化決定システムの解明2009

    • Author(s)
      岡村大治、時武裕子、谷口大史、松居靖久
    • Organizer
      文部科学省科学研究費補助金特定領域研究「生殖細胞の世代サイクルとエピゲノムネットワーク」による公開シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2009-11-27
    • Data Source
      KAKENHI-PLANNED-20062001
  • [Presentation] Requirement of Oct3/4 function for germ cell specification.2008

    • Author(s)
      Okamura, D
    • Organizer
      Joint meeting of the societe Francaise de Biologie du Development/Japanese Society of Developmental Biologists, 'Frontiers in Developmental Biology'
    • Place of Presentation
      Presqu'ile de Giens, France
    • Data Source
      KAKENHI-PLANNED-20062001
  • [Presentation] Requirement of Oct3/4 function for germ cell specification2008

    • Author(s)
      D. Okamura, Y. Tokitake, H. Niwa and Y. Matsui
    • Organizer
      Joint meeting of the societe Francaise de Biologie du Development /Japanese Society of Developmental Biologists, 'Frontiers in Developmental Biology'
    • Place of Presentation
      Presqu'ile de Giens, France
    • Data Source
      KAKENHI-PLANNED-20062001
  • [Presentation] Requirement of Oct3/4 function for germ cell specification2008

    • Author(s)
      Okamura et.al.
    • Organizer
      Frontiers in Developmental Biology
    • Place of Presentation
      Giens, Southern France
    • Data Source
      KAKENHI-PROJECT-20770170
  • [Presentation] Frontiers in Developmental Biology2008

    • Author(s)
      Okamura, et al.
    • Organizer
      Requirement of Oct3/4 function for germ cell specification.
    • Place of Presentation
      Giens, Southern France
    • Data Source
      KAKENHI-PROJECT-20770170
  • 1.  Mitani Tasuku (10322265)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 2.  田辺 秀之 (50261178)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  MAEDA Ikuma (20376560)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 4.  MATSUI Yasuhisa (40241575)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 13 results
  • 5.  NOCE Toshiaki (70183902)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 6.  丹藤 由希子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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