Kii Isao 喜井勲

… Alternative Names

KII Isao 喜井勲

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Researcher Number	80401561
Other IDs	https://orcid.org/0000-0002-6153-6250
Affiliation (Current)	2024: 信州大学, 学術研究院農学系, 教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 信州大学, 学術研究院農学系, 教授 2019: 信州大学, 学術研究院農学系, 准教授 2018: 国立研究開発法人理化学研究所, 科技ハブ産連本部, ユニットリーダー 2017: 理化学研究所, 健康生き活き羅針盤リサーチコンプレックス推進プログラム, ユニットリーダー 2016 – 2017: 国立研究開発法人理化学研究所, 科学技術ハブ推進本部, ユニットリーダー 2014: 京都大学, 大学院医学研究科, 特定助教 2007 – 2008: Tokyo Institute of Technology, 大学院・生命理工学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 43020:Structural biochemistry-related / Basic Section 37030:Chemical biology-related / Biological Sciences / Chemical biology / Functional basic dentistry Except Principal Investigator Basic Section 37020:Chemistry and chemical methodology of biomolecules-related / Medium-sized Section 49:Pathology, infection/immunology, and related fields / Chemical biology / Chemical biology
Keywords	Principal Investigator DYRK1A / リン酸化酵素 / フォールディング / 自己リン酸化 / 阻害剤 / フォールディング中間体 / 低分子化合物 / シャペロン / FINDY / 中間体 … More / 酵素反応 / スクリーニング / ATP / リボソーム / 阻害剤結合ポケット / 共翻訳フォールディング / 質量分析 / 酵素活性 / キノーム / 温度ジャンプ / 熱力学的平衡状態 / 無細胞タンパク質合成 / 非天然状態 / in vitro翻訳 / 熱力学安定性 / 活性ドメイン / 遷移状態 / Phase separation / 核 / 品質管理機構 / 細胞内 / 準安定状態 / 品質管理 / プロテアソーム / ユビキチン / 分子シャペロン / 創薬 / 有機化学 / 構造展開 / 特異的阻害剤 / 化合物 / 分子内自己リン酸化 / メカニカルストレス / 線維芽細胞 / 心破裂 / 心筋梗塞 / メッシュワーク構造 / フィブロネクチン / テネイシン-C / シンスプリント / 脛骨過労性骨膜炎 / 骨芽細胞 / 細胞外マトリックス / メカノセンシング / コラーゲン / 骨外膜 / 歯根膜 / ペリオスチン … More Except Principal Investigator クリック反応 / アジド / 環状アルキン / 有機化学 / ケミカルバイオロジー / 化学修飾 / 光反応 / トリアゼン / 治療法 / アルツハイマー病 / 異常凝集体 / 神経細胞死 / 神経変性疾患 / 分子連結 / アライン / 分子プローブ / 機能集積 / アルキン / 化学プローブ Less

リボソーム表面に捕捉されたリン酸化酵素フォールディング中間体の構造解明と創薬応用Principal Investigator
- Principal Investigator
  
  喜井勲
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Shinshu University
多機能化のための生体親和性クリックケミストリーの創成
- Principal Investigator
  
  細谷孝充
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Tokyo Medical and Dental University
多機能化一本鎖抗体によるアミロイドβ凝集体細胞内スワイプ療法の開発
- Principal Investigator
  
  星美奈子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Foundation for Biomedical Research and Innovation at Kobe
Drug discovery targeting folding intermediates of kinasesPrincipal Investigator
- Principal Investigator
  
  Kii Isao
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Shinshu University
リン酸化酵素の活性・阻害に影響を与える細胞内分子夾雑環境の理解と創薬応用Principal Investigator
- Principal Investigator
  
  喜井勲
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  Shinshu University
  Institute of Physical and Chemical Research
リン酸化酵素の新生鎖における品質管理機構の解明Principal Investigator
- Principal Investigator
  
  喜井勲
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Institute of Physical and Chemical Research
Drug Development Targeting a Folding Intermediate of KinasePrincipal Investigator
- Principal Investigator
  
  Kii Isao
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Chemical biology
- Research Institution
  Institute of Physical and Chemical Research
Practical Click Chemistry for Development of Highly Functional Probes
- Principal Investigator
  
  HOSOYA Takamitsu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical biology
- Research Institution
  Tokyo Medical and Dental University
Novel click chemistries for chemical biology researches
- Principal Investigator
  
  HOSOYA Takamitsu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical biology
- Research Institution
  Tokyo Medical and Dental University
Mechanosensing mechanism organized by periostin in periodontal ligament and periosteumPrincipal Investigator
- Principal Investigator
  
  KII Isao
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Tokyo Institute of Technology

All 2023 2022 2021 2020 2019 2018 2017 2016 2013 2009 2008 Other

All Journal Article Presentation Patent

[Journal Article] Structure-activity relationship for the folding intermediate-selective inhibition of DYRK1A2022
- Author(s)
  Miyazaki Yuka、Kikuchi Masaki、Umezawa Koji、Descamps Aurelie、Nakamura Daichi、Furuie Gaku、Sumida Tomoe、Saito Kanako、Kimura Ninako、Niwa Takashi、Sumida Yuto、Umehara Takashi、Hosoya Takamitsu、Kii Isao
- Journal Title
  
  European Journal of Medicinal Chemistry
  
  Volume: 227 Pages: 113948-113948
- DOI
  10.1016/j.ejmech.2021.113948
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03388, KAKENHI-PROJECT-19H02856
[Journal Article] Expression and purification of DYRK1A kinase domain in complex with its folding intermediate-selective inhibitor FINDY2022
- Author(s)
  Kimura Ninako、Saito Kanako、Niwa Takashi、Yamakawa Masato、Igaue Shota、Ohkanda Junko、Hosoya Takamitsu、Kii Isao
- Journal Title
  
  Protein Expression and Purification
  
  Volume: 195-196 Pages: 106089-106089
- DOI
  10.1016/j.pep.2022.106089
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H02856, KAKENHI-PROJECT-21H02077
[Journal Article] Druggable Transient Pockets in Protein Kinases2021
- Author(s)
  Umezawa Koji、Kii Isao
- Journal Title
  
  Molecules
  
  Volume: 26 Issue: 3 Pages: 651-651
- DOI
  10.3390/molecules26030651
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H02856
[Journal Article] S1PR3?G12-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation2021
- Author(s)
  Toyomoto Masayasu、Inoue Asuka、Iida Kei、Denawa Masatsugu、Kii Isao、Ngako Kadji Francois Marie、Kishi Takayuki、Im Dohyun、Shimamura Tatsuro、Onogi Hiroshi、Yoshida Suguru、Iwata So、Aoki Junken、Hosoya Takamitsu、Hagiwara Masatoshi
- Journal Title
  
  Cell Chemical Biology
  
  Volume: 未定 Issue: 8 Pages: 1132-1144
- DOI
  10.1016/j.chembiol.2021.01.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-19H02856, KAKENHI-ORGANIZER-19H05776, KAKENHI-PLANNED-19H05777, KAKENHI-PROJECT-20K21392, KAKENHI-PROJECT-18H02388, KAKENHI-PROJECT-21H02414
[Journal Article] Assembly of four modules onto a tetraazide platform by consecutive 1,2,3-triazole formations2021
- Author(s)
  Yoshida Suguru、Sakata Yuki、Misawa Yoshihiro、Morita Takamoto、Kuribara Tomoko、Ito Harumi、Koike Yuka、Kii Isao、Hosoya Takamitsu
- Journal Title
  
  Chemical Communications
  
  Volume: 57 Issue: 7 Pages: 899-902
- DOI
  10.1039/d0cc07789e
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05451, KAKENHI-PROJECT-18H02104, KAKENHI-PROJECT-19H02856
[Journal Article] Indolizines enabling rapid uncaging of alcohols and carboxylic acids by red light-induced photooxidation2020
- Author(s)
  Kenji Watanabe, Nodoka Terao, Isao Kii, Reiko Nakagawa, Takashi Niwa, Takamitsu Hosoya
- Journal Title
  
  Organic Letters
  
  Volume: 22 Issue: 14 Pages: 5434-5438
- DOI
  10.1021/acs.orglett.0c01799
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05707, KAKENHI-PROJECT-19H02856
[Journal Article] HaloTag-based conjugation of proteins to barcoding-oligonucleotides2020
- Author(s)
  3.Yazaki J*, Kawashima Y, Ogawa T, Kobayashi A, Okoshi M, Watanabe T, Yoshida S, Kii I, Egami S, Amagai M, Hosoya T, Shiroguchi K, Ohara O
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 48 Issue: 2 Pages: e8-e8
- DOI
  10.1093/nar/gkz1086
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05411, KAKENHI-PROJECT-19K05745, KAKENHI-PROJECT-19H02856
[Journal Article] Identification of synthetic inhibitors for the DNA binding of intrinsically disordered circadian clock transcription factors2020
- Author(s)
  Hosoya Yusuke、Nojo Wataru、Kii Isao、Suzuki Takanori、Imanishi Miki、Ohkanda Junko
- Journal Title
  
  Chemical Communications
  
  Volume: 56 Issue: 76 Pages: 11203-11206
- DOI
  10.1039/d0cc04861e
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-20H04769, KAKENHI-PROJECT-18H02106, KAKENHI-PROJECT-19H02856, KAKENHI-PROJECT-23K20275
[Journal Article] Screening of novel drugs for inhibiting hepatitis E virus replication2019
- Author(s)
  Nishiyama T, Kobayashi T, Jirintai S, Kii I, Nagashima S, Primadharsini PP, Nishizawa T, Okamoto H.
- Journal Title
  
  Journal of Virological Methods
  
  Volume: 270 Pages: 1-11
- DOI
  10.1016/j.jviromet.2019.04.017
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07579, KAKENHI-PROJECT-19H02856
[Journal Article] A facile preparation of functional cycloalkynes via an azide-to-cycloalkyne switching approach2019
- Author(s)
  Yoshida Suguru、Kuribara Tomoko、Ito Harumi、Meguro Tomohiro、Nishiyama Yoshitake、Karaki Fumika、Hatakeyama Yasutomo、Koike Yuka、Kii Isao、Hosoya Takamitsu
- Journal Title
  
  Chemical Communications
  
  Volume: 55 Issue: 24 Pages: 3556-3559
- DOI
  10.1039/c9cc01113g
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06414, KAKENHI-PUBLICLY-18H04386, KAKENHI-PROJECT-18H02104, KAKENHI-PROJECT-18J11113, KAKENHI-PROJECT-17K13266, KAKENHI-PUBLICLY-18H04568
[Journal Article] Staudinger reaction using 2,6-dichlorophenyl azide derivatives for robust aza-ylide formation applicable to bioconjugation in living cells2018
- Author(s)
  Meguro Tomohiro、Terashima Norikazu、Ito Harumi、Koike Yuka、Kii Isao、Yoshida Suguru、Hosoya Takamitsu
- Journal Title
  
  Chemical Communications
  
  Volume: 54 Issue: 57 Pages: 7904-7907
- DOI
  10.1039/c8cc00179k
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06414, KAKENHI-PUBLICLY-18H04386, KAKENHI-PROJECT-18H02104, KAKENHI-PROJECT-18J11113, KAKENHI-PUBLICLY-18H04568
[Journal Article] Convergent synthesis of trifunctional molecules by three sequential azido-type-selective cycloadditions2018
- Author(s)
  Yoshida Suguru、Kanno Kimiyuki、Kii Isao、Misawa Yoshihiro、Hagiwara Masatoshi、Hosoya Takamitsu
- Journal Title
  
  Chemical Communications
  
  Volume: 54 Issue: 30 Pages: 3705-3708
- DOI
  10.1039/c8cc01195h
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01133, KAKENHI-PROJECT-15H03118, KAKENHI-PLANNED-17H06414, KAKENHI-PROJECT-15H05721
[Journal Article] Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice2017
- Author(s)
  Akiko Nakano-Kobayashi, Tomonari Awaya, Isao Kii, Yuto Sumida, Yukiko Okuno, Suguru Yoshida, Tomoe Sumida, Haruhisa Inoue, Takamitsu Hosoya and Masatoshi Hagiwara
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of america
  
  Volume: 114 Issue: 38 Pages: 10268-10273
- DOI
  10.1073/pnas.1704143114
- NAID
  130007900113
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K01932, KAKENHI-PROJECT-15H05721, KAKENHI-PROJECT-16H05926, KAKENHI-PROJECT-21249013, KAKENHI-PROJECT-16K17907
[Journal Article] DYRK1B mutations associated with metabolic syndrome impair the chaperone-dependent maturation of the kinase domain2017
- Author(s)
  Abu Jhaisha Samira、Widowati Esti W.、Kii Isao、Sonamoto Rie、Knapp Stefan、Papadopoulos Chrisovalantis、Becker Walter
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 6420-6420
- DOI
  10.1038/s41598-017-06874-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05678, KAKENHI-PROJECT-16H05926
[Journal Article] Selective inhibition of the kinase DYRK1A by targeting its folding process2016
- Author(s)
  Kii I., Sumida Y., Goto T., Sonamoto R., Okuno Y., Yoshida S., Kato-Sumida T., Koike Y., Abe M., Nonaka Y., Ikura T., Ito N., Shibuya H., Hosoya T., Hagiwara M.
- Journal Title
  
  Nat. Commun.
  
  Volume: 該当なし Issue: 1 Pages: 11391-11391
- DOI
  10.1038/ncomms11391
- NAID
  120005770755
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08262, KAKENHI-PROJECT-16H05926, KAKENHI-PROJECT-15H05721, KAKENHI-PROJECT-21249013
[Journal Article] Periostin, a novel marker of intramembranous ossification, is expressed in fibrous dysplasia and in c-Fos-overexpressing bone lesions2009
- Author(s)
  Kashima TG, Nishiyama T, Shimazu K, Shimazaki M, Kii I, Grigoriadis AE, Fukayama M, Kudo A
- Journal Title
  
  Hum Pathol. 40(2)
  
  Pages: 226-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19791362
[Journal Article] Periostin, a novel marker of intramembranous ossification, is expressed in fibrous dysplasia and in c-Fos-overexpressing bone lesions2009
- Author(s)
  Kashima TG, Nishiyama T, Shimazu K, Shimazaki M, Kii I, Grigoriadis AE, Fukayama M, Kudo A.
- Journal Title
  
  Hum Pathol 40
  
  Pages: 226-237
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19791362
[Journal Article] Periostin is essential for cardiac healing after acute myocardial infarction2008
- Author(s)
  Shimazaki M, Nakamura K, Kii I, Kashima T, Amizuka N, Li M, Saito M, Fukuda K, Nishiyama T, Kitajima S, Saga Y, Fukayama M, Sata M, Kudo A
- Journal Title
  
  J Exp Med. 205(2)
  
  Pages: 295-303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19791362
[Journal Article] Periostin is essential for cardiac healing after acute myocardial infarction2008
- Author(s)
  Shimazaki M, Nakamura K, kii I, Kashima T, Amizuka N, Li M, Saito M, Fukuda K, Nishiyama T, Kitajima S, Saga Y, Fukaya ma M, Sata M, Kudo A.
- Journal Title
  
  The Journal of Experimental Medicine 205(2)
  
  Pages: 295-303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19791362
[Journal Article] Periostin is expressed in pericryptal fibroblasts and cancer-associated fibroblasts in the colon2008
- Author(s)
  Kikuchi Y, Kashima TG, Nishiyama T, Shimazu K, Morishita Y, Shimazaki M, Kii I, Horie H, Nagai H, Kudo A, Fukayama M
- Journal Title
  
  J Histochem Cytochem. 56(8)
  
  Pages: 753-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19791362
[Journal Article] Periostin is expressed in pericryptal fibroblasts and cancer-associated fibroblasts in the colon2008
- Author(s)
  Kikuchi Y, Kashima TG, Nishiyama T, Shimazu K, Morishita Y, Shimazaki M, Kii I, Horie H, Nagai H, Kudo A. Fukavama M.
- Journal Title
  
  J Histochem Cytochem 56
  
  Pages: 753-764
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19791362
[Patent] 選択的機能性物質の探索方法、選択的機能性物資探索装置、選択的機能性物質探索方法、および、プログラム2021
- Inventor(s)
  喜井勲、古家岳、梅澤公二
- Industrial Property Rights Holder
  信州大学
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-19H02856
[Patent] 選択的阻害剤の探索方法、選択的阻害剤探索装置、選択的阻害剤探索方法、および、プログラム2020
- Inventor(s)
  喜井勲、古家岳、梅澤公二
- Industrial Property Rights Holder
  喜井勲、古家岳、梅澤公二
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-201892
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19H02856
[Presentation] 環状アルキン－コバルト錯体の新規脱コバルト化法を基盤とした機能性ジベンゾアザシクロオクチン類の簡便合成2023
- Author(s)
  坂田優希, 鍋倉涼斗, 陌間由貴, 半矢実保, 西山尚志, 喜井勲, 細谷孝充
- Organizer
  日本ケミカルバイオロジー学会第17回年会
- Data Source
  KAKENHI-PROJECT-23K26784
[Presentation] リン酸化酵素DYRK1Aのフォールディング中間体選択的阻害の構造活性相関2022
- Author(s)
  宮崎侑香、菊地正樹、梅澤公二、Aurelie Descamps、中村大地、古家岳、隅田ともえ、斉藤佳南子、木村仁奈子、丹羽節、隅田有人、梅原崇史、細谷孝充、喜井勲
- Organizer
  日本ケミカルバイオロジー学会　第16回年会
- Data Source
  KAKENHI-PROJECT-19H02856
[Presentation] 標的タンパク質の準安定状態に結合する阻害剤は解離が遅い2022
- Author(s)
  鈴木空、喜井勲
- Organizer
  第13回スクリーニング学研究会
- Data Source
  KAKENHI-PROJECT-19H02856
[Presentation] リン酸化酵素フォールディング中間体選択的阻害のハイスループット定量評価系2022
- Author(s)
  古家岳、梅澤公二、菊地正樹、鈴木空、木村仁奈子、山川真慧、丹羽節、細谷孝充、梅原崇史、喜井勲
- Organizer
  日本ケミカルバイオロジー学会　第16回年会
- Data Source
  KAKENHI-PROJECT-19H02856
[Presentation] リン酸化酵素フォールディング中間体を標的とした創薬研究2020
- Author(s)
  喜井　勲
- Organizer
  第24回日本がん分子標的治療学会学術集会シンポジウム1　ケミカルバイオロジーの新展開と創薬
- Invited
- Data Source
  KAKENHI-PROJECT-19H02856
[Presentation] リン酸化酵素のフォールディング中間体を標的とした創薬研究2020
- Author(s)
  喜井　勲
- Organizer
  2nd WPI-NanoLSI Special Seminar -Frontiers in Chem-Bio-
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04568
[Presentation] リン酸化酵素のフォールディング中間体を標的とした創薬研究2020
- Author(s)
  喜井　勲
- Organizer
  2nd WPI-NanoLSI Special Seminar -Frontiers in Chem-Bio-
- Invited
- Data Source
  KAKENHI-PROJECT-19H02856
[Presentation] リン酸化酵素のフォールディング中間体を標的とした創薬研究2019
- Author(s)
  喜井　勲
- Organizer
  新学術領域「分子夾雑の生命化学」第2回関東地区シンポジウム
- Data Source
  KAKENHI-PUBLICLY-18H04568
[Presentation] リン酸化酵素のフォールディング中間体を標的とした創薬研究2019
- Author(s)
  喜井　勲
- Organizer
  水無月セミナー＠大阪大学蛋白質研究所
- Invited
- Data Source
  KAKENHI-PROJECT-19H02856
[Presentation] HaloTagのタンデム化による高感度蛍光イメージング2019
- Author(s)
  喜井　勲
- Organizer
  第４回メカノバイオロジー学会学術大会
- Data Source
  KAKENHI-PROJECT-16H05926
[Presentation] リン酸化酵素のフォールディング中間体を標的とした創薬研究2019
- Author(s)
  喜井　勲
- Organizer
  新学術領域「分子夾雑の生命化学」第2回関東地区シンポジウム
- Data Source
  KAKENHI-PROJECT-19H02856
[Presentation] リン酸化酵素のフォールディング中間体を標的とした創薬研究2019
- Author(s)
  喜井　勲
- Organizer
  第８回生命科学阿波おどりシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19H02856
[Presentation] リン酸化酵素のフォールディング中間体を標的とした創薬研究2019
- Author(s)
  喜井　勲
- Organizer
  水無月セミナー＠大阪大学蛋白質研究所
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04568
[Presentation] リン酸化酵素の新生鎖における品質管理機構の解明2019
- Author(s)
  喜井　勲
- Organizer
  新学術領域「新生鎖の生物学」領域会議
- Data Source
  KAKENHI-PUBLICLY-17H05678
[Presentation] リン酸化酵素のフォールディング中間体を標的とした創薬研究2019
- Author(s)
  喜井　勲
- Organizer
  第８回生命科学阿波おどりシンポジウム
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04568
[Presentation] タンデムHaloTagによる高感度蛍光イメージング技術の開発2018
- Author(s)
  喜井　勲
- Organizer
  新学術領域「新生鎖の生物学」第５回若手ワークショップ
- Data Source
  KAKENHI-PUBLICLY-17H05678
[Presentation] リン酸化酵素フォールディング中間体を標的とした創薬研究2018
- Author(s)
  喜井　勲
- Organizer
  新学術領域「中分子戦略」「分子夾雑化学」ジョイントシンポジウム・第21回生命化学研究会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05926
[Presentation] Cotranslational ubiquitinationとmRNA安定性の関連性についての仮説2018
- Author(s)
  喜井　勲
- Organizer
  第６回CCR4-NOT研究会
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05678
[Presentation] An alternative strategy to develop a selective kinase inhibitor2018
- Author(s)
  喜井　勲
- Organizer
  京都大学特別学術セミナー
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04568
[Presentation] Cotranslational ubiquitinationとmRNA安定性の関連性についての仮説2018
- Author(s)
  喜井　勲
- Organizer
  第６回CCR4-NOT研究会
- Data Source
  KAKENHI-PROJECT-16H05926
[Presentation] An alternative strategy to develop a selective kinase inhibitor2018
- Author(s)
  喜井　勲
- Organizer
  京都大学大学院　特別学術セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-16H05926
[Presentation] An alternative strategy to develop a selective kinase inhibitor2018
- Author(s)
  喜井　勲
- Organizer
  国立遺伝学研究所 The Biological Symposium
- Invited
- Data Source
  KAKENHI-PROJECT-16H05926
[Presentation] リン酸化酵素フォールディング中間体を標的とした創薬研究2018
- Author(s)
  喜井　勲
- Organizer
  新学術領域「中分子戦略」「分子夾雑化学」ジョイントシンポジウム・第21回生命化学研究会
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04568
[Presentation] リン酸化酵素のフォールディング中間体を標的とした創薬研究2018
- Author(s)
  喜井　勲
- Organizer
  秋田大学大学院医学系研究科　大学院セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-16H05926
[Presentation] Selective inhibition of the kinase DYRK1A by targeting its folding process2018
- Author(s)
  Isao Kii
- Organizer
  International Symposium on “Proteins; from the Cradle to the Grave”
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05678
[Presentation] Selective inhibition of the kinase DYRK1A by targeting its folding process2017
- Author(s)
  喜井　勲
- Organizer
  「新生鎖の生物学」第4回若手ワークショップ
- Data Source
  KAKENHI-PUBLICLY-17H05678
[Presentation] Selective inhibition of the kinase DYRK1A by targeting its folding process2017
- Author(s)
  Isao Kii
- Organizer
  RIKEN SAKURA symposium 2017
- Place of Presentation
  理研　横浜事業所
- Year and Date
  2017-03-29
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05926
[Presentation] Quality control mechanism of DYRK1A folding intermediate2017
- Author(s)
  喜井　勲
- Organizer
  International Symposium on Protein quality control
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05678
[Presentation] リン酸化酵素DYRK1Aのフォールディング中間体阻害メカニズムの解析2017
- Author(s)
  喜井　勲
- Organizer
  日本ケミカルバイオロジー学会　第12回年会
- Data Source
  KAKENHI-PROJECT-16H05926
[Presentation] 低分子化合物FINDYによるリン酸化酵素DYRK1Aのフォールディング阻害メカニズムの解析2016
- Author(s)
  喜井　勲
- Organizer
  日本ケミカルバイオロジー学会　第11回年会
- Place of Presentation
  京都テルサテルサホール
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-16H05926
[Presentation] Selective inhibition of the kinase DYRK1A by targeting its folding process2016
- Author(s)
  Isao Kii
- Organizer
  207th iCeMS Seminar
- Place of Presentation
  京都大学
- Year and Date
  2016-07-06
- Invited
- Data Source
  KAKENHI-PROJECT-16H05926
[Presentation] 異種アジト選択的逐次クリック反応 : 機能性分子集積への展開2013
- Author(s)
  菅野貴美幸、吉田優、喜井勲、松下武司、萩原正敏、細谷孝充
- Organizer
  日本化学会第93春季年会
- Place of Presentation
  立命館大学びわこ・くさつキャンパス
- Year and Date
  2013-03-23
- Data Source
  KAKENHI-PROJECT-24310164
[Presentation] ペリオスチンは、ゴルジ体においてフィプロネクチンとテネイシン-Cの結合の足場として機能し、脛骨過労性骨膜炎の発症を抑制する2008
- Author(s)
  喜井勲
- Organizer
  第26回日本骨代謝学会学術集会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2008-10-30
- Data Source
  KAKENHI-PROJECT-19791362
[Presentation] ペリオスチンは、ゴルジ体においてフィブロネクチンとテネイシン-Cの結合の足場として機能し、脛骨過労性骨膜炎の発症を抑制する2008
- Author(s)
  喜井勲
- Organizer
  第26回日本骨代謝学会学術集会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2008-10-30
- Data Source
  KAKENHI-PROJECT-19791362
[Presentation] 異種アジド選択的トリプルクリック反応による機能性分子集積
- Author(s)
  吉田　優、菅野貴美幸、喜井　勲、松下武司、萩原正敏、細谷孝充
- Organizer
  日本ケミカルバイオロジー学会　第8回年会
- Place of Presentation
  東京医科歯科大学湯島キャンパス（東京）
- Data Source
  KAKENHI-PROJECT-24310164
[Presentation] Sequential Triple-Click Reaction by Three Azido-Type Selective Cycloadditions
- Author(s)
  細谷孝充、吉田　優、菅野貴美幸、喜井　勲、松下武司、萩原正敏
- Organizer
  The First Asian Conference for "MONODUKURI" Strategy by Synthetic Organic Chemistry (ACMS)
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-24310164
[Presentation] Facile Synthesis of Trifunctional Probe by a Sequential Triple-click Reaction
- Author(s)
  吉田　優、菅野貴美幸、喜井　勲、松下武司、萩原正敏、細谷孝充
- Organizer
  2nd Annual Conference of the International Chemical Biology Society (ICBS2013)
- Place of Presentation
  京都大学芝蘭会館（京都）
- Data Source
  KAKENHI-PROJECT-24310164
[Presentation] 異種アジド基の特性にもとづく逐次マルチクリック反応の開発
- Author(s)
  細谷孝充，吉田　優，菅野貴美幸，喜井　勲，森田隆太，田中淳子，松下武司，萩原正敏
- Organizer
  第43回複素環化学討論会
- Place of Presentation
  長良川国際会議場（岐阜）
- Data Source
  KAKENHI-PROJECT-24310164
[Presentation] 多機能性分子プローブ創製に有用な異種アジド選択的逐次クリック反応の開発
- Author(s)
  吉田　優、菅野貴美幸、喜井　勲、松下武司、萩原正敏、細谷孝充
- Organizer
  第103回有機合成シンポジウム
- Place of Presentation
  慶應義塾大学白金キャンパス（東京）
- Data Source
  KAKENHI-PROJECT-24310164

1. HOSOYA Takamitsu (60273124)

# of Collaborated Projects: 4 results

# of Collaborated Products: 10 results
2. 丹羽節 (30584396)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 星美奈子 (30374010)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 村松慎一 (10239543)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 笹原智也 (30735345)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 石井佳誉 (40799045)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 豊島近 (70172210)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 梅澤公二 (00609258)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 坂田優希 (40896825)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. UMEHARA Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. SHIROGUCHI Katsuyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. NAGASHIMA Shigeo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. IWATA So

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. GOTO Toshiyasu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 小林亜希子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 渡辺賢司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 吉田秀郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
18. 吉田優

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 大神田淳子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kii Isao 喜井 勲

KII Isao 喜井 勲

Research Projects

Research Products

Co-Researchers

リボソーム表面に捕捉されたリン酸化酵素フォールディング中間体の構造解明と創薬応用Principal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

多機能化のための生体親和性クリックケミストリーの創成

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

多機能化一本鎖抗体によるアミロイドβ凝集体細胞内スワイプ療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Drug discovery targeting folding intermediates of kinasesPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

リン酸化酵素の活性・阻害に影響を与える細胞内分子夾雑環境の理解と創薬応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

リン酸化酵素の新生鎖における品質管理機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Drug Development Targeting a Folding Intermediate of KinasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Practical Click Chemistry for Development of Highly Functional Probes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel click chemistries for chemical biology researches

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanosensing mechanism organized by periostin in periodontal ligament and periosteumPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Structure-activity relationship for the folding intermediate-selective inhibition of DYRK1A2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Expression and purification of DYRK1A kinase domain in complex with its folding intermediate-selective inhibitor FINDY2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Druggable Transient Pockets in Protein Kinases2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] S1PR3?G12-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation2021

Kii Isao 喜井勲

KII Isao 喜井勲