Yamaguchi Tomoyuki 山口智之

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YAMAGUCHI Tomoyuki 山口智之

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Researcher Number	80402791
Other IDs
Affiliation (Current)	2025: 医療法人徳洲会野崎徳洲会病院(附属研究所), 研究所, 主任研究員
Affiliation (based on the past Project Information) *help	2017: 医療法人徳洲会野崎徳洲会病院(附属研究所), 研究所, 主任研究員 2016: 大阪大学, 免疫学フロンティア研究センター, 特任准教授(常勤) 2015: 大阪大学, 免疫学フロンティア研究センター, 特任准教授 2011 – 2012: 大阪大学, 免疫学フロンティア研究センター, 特任准教授 2008 – 2010: 京都大学, 再生医科学研究所, 助教
Review Section/Research Field	Principal Investigator Immunology Except Principal Investigator Biological Sciences
Keywords	Principal Investigator 免疫寛容 / 選択的増殖 / 多様性 / 免疫制御モデル / 免疫チェックポイン / ゆらぎ / 不安定性 / 数理モデル / 制御性T細胞 Except Principal Investigator T細胞抗原レセプター … More / Ｔ細胞抗原レセプター / Ｔリンパ球 / エピゲノム / 制御性Ｔ細胞 / 免疫制御 / CTLA-4 / Tリンパ球 / 自己免疫病 / 制御性T細胞 / FOXP3 Less

Theoretical and experimental analyses to reveal the mechanisms of immune regulationPrincipal Investigator
- Principal Investigator
  
  Yamaguchi Tomoyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  医療法人徳洲会野崎徳洲会病院(附属研究所)
  Osaka University
Molecular basis of the function and generation of Foxp3-expressing regulatory T cells
- Principal Investigator
  
  SAKAGUCHI Shimon
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
  Kyoto University

All 2018 2017 2016 2015 2012 2011 2010 2009 2008 Other

All Journal Article Presentation

[Journal Article] UVB Exposure Prevents Atherosclerosis by Regulating Immunoinflammatory Responses.2017
- Author(s)
  Sasaki, N., T. Yamashita, K. Kasahara, A. Fukunaga, T. Yamaguchi, T. Emoto, K. Yodoi, T. Matsumoto, K. Nakajima, T. Kita, M. Takeda, T. Mizoguchi, T. Hayashi, Y. Sasaki, M. Hatakeyama, K. Taguchi, K. Washio, S. Sakaguchi, B. Malissen, C. Nishigori, and K.I. Hirata
- Journal Title
  
  Arterioscler Thromb Vasc Biol
  
  Volume: 37(1) Issue: 1 Pages: 66-74
- DOI
  10.1161/atvbaha.116.308063
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08530, KAKENHI-PROJECT-15K09156, KAKENHI-PROJECT-16K09516, KAKENHI-PROJECT-16H06295, KAKENHI-PROJECT-15K09742
[Journal Article] Robust and Accurate Discrimination of Self/Non-Self Antigen Presentations by Regulatory T Cell Suppression.2016
- Author(s)
  Furusawa, C. and T. Yamaguchi
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 9 Pages: e0163134-e0163134
- DOI
  10.1371/journal.pone.0163134
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08530, KAKENHI-PROJECT-15H05746
[Journal Article] Overexpression of Cytotoxic T-Lymphocyte–Associated Antigen-4 Prevents Atherosclerosis in Mice2016
- Author(s)
  Takuya Matsumoto, Naoto Sasaki, Tomoya Yamashita, Takuo Emoto, Kazuyuki Kasahara, Taiji Mizoguchi, Tomohiro Hayashi, Keiko Yodoi, Naoki kitano, Takashi Saito, Tomoyuki Yamaguchi, and Ken-ichi Hirata
- Journal Title
  
  Arterioscler Thromb Vasc Biol.
  
  Volume: 36 Issue: 6 Pages: 1141-51
- DOI
  10.1161/atvbaha.115.306848
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08530, KAKENHI-PROJECT-24229004, KAKENHI-PROJECT-15K09156, KAKENHI-PROJECT-16K09516
[Journal Article] Non-label immune cell state prediction using Raman spectroscopy2016
- Author(s)
  Taro Ichimura, Liang-da Chiu, Katsumasa Fujita, Hiroaki Machiyama, Tomoyuki Yamaguchi, Tomonobu M. Watanabe, and Hideaki Fujita
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 37562-37562
- DOI
  10.1038/srep37562
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01439, KAKENHI-PROJECT-26286063, KAKENHI-PROJECT-15K20950, KAKENHI-PROJECT-15K08530, KAKENHI-PROJECT-16K14717, KAKENHI-PROJECT-15K19128, KAKENHI-PROJECT-26291028
[Journal Article] SH3 domain of c-Src governs its dynamics at focal adhesions and the cell membrane2015
- Author(s)
  Machiyama H, Yamaguchi T, Sawada Y, Watanabe T, Fujita H
- Journal Title
  
  FEBS Journal
  
  Volume: 282 Issue: 20 Pages: 4034-4055
- DOI
  10.1111/febs.13404
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08530, KAKENHI-PLANNED-23115002, KAKENHI-PROJECT-26291028
[Journal Article] Two modes of immune suppression by Foxp3(十) regulatory T cells under inflammatory or non-inflammatory conditions2012
- Author(s)
  Yamaguchi, T., Wing, J.B., Sakaguchi, S.
- Journal Title
  
  Semin Immunol
  
  Volume: 23 Pages: 424-430
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon.2012
- Author(s)
  Kinoshita M, Kayama H, Kusu T, Yamaguchi T, Kunisawa J, Kiyono H, Sakaguchi S, Takeda K.
- Journal Title
  
  J Immunol.
  
  Volume: 189 Pages: 2869-78
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon2012
- Author(s)
  Kinoshita M, Kayama H, Kusu T, Yamaguchi T, Kunisawa J, Kiyono H, Sakaguchi S, Takeda K
- Journal Title
  
  J Immunol
  
  Volume: 189 Pages: 2869-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Two modes of immune suppression by Foxp3(+) regulatory T cells under inflammatory or non-inflammatory conditions2011
- Author(s)
  Yamaguchi, T., Wing, J. B., Sakaguchi, S.
- Journal Title
  
  Semin Immunol.
  
  Volume: 23 Pages: 424-430
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Cell-autonomous and -nonautonomous functions of CTLA-4 for negative control of immune responses2011
- Author(s)
  Wing, K., Yamaguchi, T., Sakaguchi, S.
- Journal Title
  
  Trends Immunol.
  
  Volume: 32 Pages: 428-43
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Cell-autonomous and -nonautonomous functions of CTLA-4 for negative control of immune responses2011
- Author(s)
  Wing, K., Yamaguchi, T, Sakaguchi, S.
- Journal Title
  
  Trends Immunol
  
  Volume: 32 Pages: 428-433
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo2011
- Author(s)
  Satou, Y., Yasunaga, J., Zhao, T., Yoshida, M., Miyazato, P., Takai, K., Shimizu, K., Ohshima, K., Green, P.L., Ohkura, N., Yamaguchi, T., Ono, M., Sakaguchi, S., Matsuoka, M.
- Journal Title
  
  PLoS Pathog
  
  Volume: 7(2)
- NAID
  120002807462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo.2011
- Author(s)
  Satou, Y., Yasunaga, J., Zhao, T., Yoshida, M., Miyazato, P., Takai, K., Shimizu, K., Ohshima, K., Green, P. L., Ohkura, N., Yamaguchi, T., Ono, M., Sakaguchi, S., Matsuoka, M.
- Journal Title
  
  PLoS Pathog.
  
  Volume: 7(2)
- NAID
  120002807462
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Multiple antitumor mechanisms downstream of prophylactic regulatory T-cell depletion.2010
- Author(s)
  Teng, M.W., Swann, J.B., von Scheidt B, Sharkey, J., Zerafa, N., McLaughlin, N., Yamaguchi, T., Sakaguchi, S., Darcy, P.K., Smyth, M.J.
- Journal Title
  
  Cancer Res. 70
  
  Pages: 2665-2674
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Multiple antitumor mechanisms downstream of prophylactic regulatory T-cell depletion.2010
- Author(s)
  Teng, M.W., Swann, J.B., von Scheidt B, Sharkey, J., Zerafa, N., McLaughlin, N., Yamaguchi, T., Sakaguchi, S., Darcy, P.K., and Smyth,M.J.
- Journal Title
  
  Cancer Res
  
  Volume: 70 Pages: 2665-2674
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Indispensable role of in vivo suppressive function of FoxP3+ regulatory T cells.2009
- Author(s)
  Kitoh, A., Ono, M., Naoe, Y., Ohkura, N., Yamaguchi, T, Yaguchi, H., Kitabayashi, I., Tsukada, T., Nomura, T., Miyachi, Y., Taniuchi, I., Sakaguchi, S.
- Journal Title
  
  Immunity. 31
  
  Pages: 609-620
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Dynamics of peripheral tolerance and immune regulation mediated by Treg.2009
- Author(s)
  Sakaguchi, S., Wing, K., Yamaguchi, T.
- Journal Title
  
  Eur. J.Immunol. 39
  
  Pages: 2331-2336
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Regulatory T cells : how do they suppress immune responses?2009
- Author(s)
  Sakaguchi S, Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T.
- Journal Title
  
  Int. Immunol. 21
  
  Pages: 1105-1111
- NAID
  10027389567
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Indispensable role of Runxl/Cbf complexes for in vivo suppressive function of FoxP^<3+> regulatory T cells.2009
- Author(s)
  Kitoh, A., Ono, M., Naoe, Y., Ohkura, N., Yamaguchi, T, Yaguchi H., Kitabayashi, I., Tsukada, T., Nomura, T., Miyachi,Y., Taniuchi, I., Sakaguchi, S.
- Journal Title
  
  Immunity. 31
  
  Pages: 609-620
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Functional delineation and differentiation dynamics of human CD4(+) Tcells expressing the FoxP3 transcription factor.2009
- Author(s)
  Miyara, M., Shima, T., Kitoh, A., Yoshioka, Y., Niwa, A., Taflin, C., Heike, T., Valeyre, D., Mathian, A., Nakahata, T., Yamaguchi T., Nomura, T., Wing, K., Ono, M., Amoura, Z., Guy Gorochov, G., Sakaguchi, S.
- Journal Title
  
  Immunity. 30
  
  Pages: 899-911
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Functional delineation and differentiation dynamics of human CD4(+) T cells expressing the FoxP3 transcription factor.2009
- Author(s)
  Miyara, M., Shima, T., Kitoh, A., Yoshioka, Y., Niwa, A., Taflin, C., Heike, T., Valeyre, D., Mathian, A., Nakahata, T., Yamaguchi T., Nomura, T., Wing, K., Ono, M., Amoura, Z., Gorochov, G., and Sakaguchi, S.
- Journal Title
  
  Immunity
  
  Volume: 30 Pages: 899-911
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Indispensable role of Runx1/Cbf・complexes for in vivo suppressive function of FoxP3+regulatory T cells2009
- Author(s)
  Kitoh, A., Ono, M., Naoe, Y., Ohkura, N., Yamaguchi, T, Yaguchi, H., Kitabayashi, I., Tsukada, T., Nomura, T., Miyachi,Y., Taniuchi, I., and Sakaguchi, S.
- Journal Title
  
  Immunity.
  
  Volume: 31 Pages: 609-620
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Dynamics of peripheral tolerance and immune regulation mediated by Treg2009
- Author(s)
  Sakaguchi, S., Wing, K., and Yamaguchi, T.
- Journal Title
  
  Eur. J. Immunol
  
  Volume: 39 Pages: 2331-6
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Functional delineation and differentiation dynamics of human CD4(+) T cells expressing the FoxP3 transcription factor.2009
- Author(s)
  Miyara, M., Shima, T., Kitoh, A., Yoshioka, Y., Niwa, A., Taflin, C., Heike, T., Valeyre, D., Mathian, A., Nakahata, T., Yamaguchi T., Nomura, T., Wing, K., Ono, M., Amoura, Z., Gorochov, G., Sakaguchi, S.
- Journal Title
  
  Immunity. 30
  
  Pages: 899-911
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation.2008
- Author(s)
  Onishi, Y., Fehervari, Z., Yamaguchi, T., Sakaguchi, S.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA. 29
  
  Pages: 10113-10118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Regulatory T cells and immune tolerance2008
- Author(s)
  Sakaguchi, S., Yamaguchi, T., Nomura, T., and Ono, M.
- Journal Title
  
  Cell
  
  Volume: 133 Pages: 775-787
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] CTLA-4 control over Foxp3^+regulatory T cell funtion2008
- Author(s)
  Wing, K., Onishi, Y., Prieto-Martin, P., Yamaguchi, T., Miyara, M.
- Journal Title
  
  Science 322
  
  Pages: 271-275
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] CTLA-4 control over Foxp3+regulatory T cell function2008
- Author(s)
  Wing, K., Onishi, Y., Prieto-Martin, P., Yamaguchi, T., Miyara, M., Fehervari, Z., Nomura, T., and Sakaguchi, S.
- Journal Title
  
  Science.
  
  Volume: 322 Pages: 271-275
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Regulatory T cell and immune tolerance2008
- Author(s)
  Sakaguchi, S., Yamaguchi, T., and Ono, M
- Journal Title
  
  Cell 133
  
  Pages: 775-787
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Foxp^<3+> natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation2008
- Author(s)
  Onishi, Y., Fehervari, Z., Yamaguchi, T., and Sakaguchi. S.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA. 29
  
  Pages: 10113-10118
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] CTLA-4 control over Foxp3+ regulatory T cell function.2008
- Author(s)
  Wing, K., Onishi, Y., Prieto-Martin, P., Yamaguchi, T., Miyara, M., Fehervari, Z., Nomura, T., Sakaguchi, S.
- Journal Title
  
  Science. 322
  
  Pages: 271-275
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Foxp3+natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation.2008
- Author(s)
  Onishi, Y., Fehervari, Z., Yamaguchi, T., and Sakaguchi, S
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 29 Pages: 10113-10118
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Construction of self-recognizing regulatory T cells from conventional T cells by controllingCTLA-4 and IL-2 expression.
- Author(s)
  Yamaguchi T, Kishi A, Osaki M, Morikawa H, Prieto-Martin P, Wing K, Saito T, and Sakaguchi S.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: (In press)
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] 免疫応答の理論モデルが示す制御性T細胞の免疫調節機構2018
- Author(s)
  山口智之
- Organizer
  第４回病因研究会別府シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-15K08530
[Presentation] 制御性T細胞による免疫調節機構の数理モデルとシミュレーション2018
- Author(s)
  山口智之
- Organizer
  第2回理論免疫学ワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-15K08530
[Presentation] A simulation model of immune response predicts essential functions of Treg to maintain immune tolerance2017
- Author(s)
  YAMAGUCHI Tomoyuki, TAKAHASHI Reiko
- Organizer
  第46回日本免疫学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08530
[Presentation] Control of immune response based on a theoretical model of T cell proliferation2016
- Author(s)
  山口　智之
- Organizer
  The 45th Annual meeting of the japanese society for immunology
- Place of Presentation
  沖縄県　宜野湾市　沖縄コンベンションセンター
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08530
[Presentation] Modeling for immune regulation2015
- Author(s)
  Tomoyuki Yamaguchi
- Organizer
  QBiC Symposium 2015
- Place of Presentation
  RIKEN Quantitative Biology Center
- Year and Date
  2015-08-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08530
[Presentation] Construction of regulatory T cells without FoxP3.2010
- Author(s)
  T.Yamaguchi, A.Kishi, M.Osaki, S.Sakaguchi
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20002007

1. SAKAGUCHI Shimon (30280770)

# of Collaborated Projects: 1 results

# of Collaborated Products: 28 results
2. OHKURA Naganari (20300949)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. NISHIKAWA Hiroyoshi (10444431)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. ITO Yoshinaga (60614013)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
5. KONDO Gen (40243258)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KITABAYASHI Issei (20261175)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. TANIUCHI Ichiro (20284573)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 谷内一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
9. 市村垂生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamaguchi Tomoyuki 山口 智之

YAMAGUCHI Tomoyuki 山口 智之

Research Projects

Research Products

Co-Researchers

Theoretical and experimental analyses to reveal the mechanisms of immune regulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular basis of the function and generation of Foxp3-expressing regulatory T cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] UVB Exposure Prevents Atherosclerosis by Regulating Immunoinflammatory Responses.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Robust and Accurate Discrimination of Self/Non-Self Antigen Presentations by Regulatory T Cell Suppression.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Overexpression of Cytotoxic T-Lymphocyte&#8211;Associated Antigen-4 Prevents Atherosclerosis in Mice2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Non-label immune cell state prediction using Raman spectroscopy2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SH3 domain of c-Src governs its dynamics at focal adhesions and the cell membrane2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Two modes of immune suppression by Foxp3(十) regulatory T cells under inflammatory or non-inflammatory conditions2012

Author(s)

Journal Title

Data Source

[Journal Article] Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon.2012

Author(s)

Journal Title

Data Source

[Journal Article] Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon2012

Author(s)

Journal Title

Data Source

[Journal Article] Two modes of immune suppression by Foxp3(+) regulatory T cells under inflammatory or non-inflammatory conditions2011

Author(s)

Journal Title

Data Source

[Journal Article] Cell-autonomous and -nonautonomous functions of CTLA-4 for negative control of immune responses2011

Author(s)

Journal Title

Data Source

[Journal Article] Cell-autonomous and -nonautonomous functions of CTLA-4 for negative control of immune responses2011

Author(s)

Journal Title

Data Source

[Journal Article] HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo.2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Multiple antitumor mechanisms downstream of prophylactic regulatory T-cell depletion.2010

Author(s)

Journal Title

Data Source

Yamaguchi Tomoyuki 山口智之

YAMAGUCHI Tomoyuki 山口智之

[Journal Article] Overexpression of Cytotoxic T-Lymphocyte–Associated Antigen-4 Prevents Atherosclerosis in Mice2016