YAMAGUCHI Tomoyuki 山口智之

Researcher Number	80402791
Affiliation *help	2017 : 医療法人徳洲会野崎徳洲会病院（附属研究所）, 研究所, 主任研究員 2016 : 大阪大学, 免疫学フロンティア研究センター, 特任准教授(常勤) 2015 : 大阪大学, 免疫学フロンティア研究センター, 特任准教授 2011 – 2012 : 大阪大学, 免疫学フロンティア研究センター, 特任准教授 2011 : 大阪大学, 免疫学フロンティア研究センター, 特任准教授（常勤） 2008 – 2010 : 京都大学, 再生医科学研究所, 助教
Review Section/Research Field	Principal Investigator Immunology Except Principal Investigator Biological Sciences
Keywords	Principal Investigator 免疫寛容 / 数理モデル / 選択的増殖 / 多様性 / 制御性T細胞 Except Principal Investigator Tリンパ球 / FOXP3 / CTLA-4 / 制御性T細胞 / 自己免疫病 … More

免疫制御機構についての理論・実験の融合的研究Principal InvestigatorOngoing
- Principal Investigator
  
  山口智之
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Osaka University
Molecular basis of the function and generation of Foxp3-expressing regulatory T cells
- Principal Investigator
  
  SAKAGUCHI Shimon
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
  Kyoto University

All 2017 2016 2015 2012 2011 2010 2009 2008 Other

All Journal Article Presentation

[Journal Article] Non-label immune cell state prediction using Raman spectroscopy2017
- Author(s)
  Taro Ichimura, Liang-da Chiu, Katsumasa Fujita, Hiroaki Machiyama, Tomoyuki Yamaguchi, Tomonobu M. Watanabe, Hideaki Fujita
- Journal Title
  
  Scientific Reports
  
  Volume : 6 Pages : 37562-37562
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19128, KAKENHI-PROJECT-26291028, KAKENHI-PUBLICLY-16H01439, KAKENHI-PROJECT-26286063, KAKENHI-PROJECT-15K20950, KAKENHI-PROJECT-15K08530, KAKENHI-PROJECT-16K14717
[Journal Article] UVB Exposure Prevents Atherosclerosis by Regulating Immunoinflammatory Responses.2017
- Author(s)
  Sasaki, N., T. Yamashita, K. Kasahara, A. Fukunaga, T. Yamaguchi, T. Emoto, K. Yodoi, T. Matsumoto, K. Nakajima, T. Kita, M. Takeda, T. Mizoguchi, T. Hayashi, Y. Sasaki, M. Hatakeyama, K. Taguchi, K. Washio, S. Sakaguchi, B. Malissen, C. Nishigori, and K.I. Hirata
- Journal Title
  
  Arterioscler Thromb Vasc Biol
  
  Volume : 37(1) Pages : 66-74
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08530, KAKENHI-PROJECT-15K09156, KAKENHI-PROJECT-16K09516
[Journal Article] Robust and Accurate Discrimination of Self/Non-Self Antigen Presentations by Regulatory T Cell Suppression.2016
- Author(s)
  Furusawa, C. and T. Yamaguchi
- Journal Title
  
  PLoS One
  
  Volume : 11
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08530
[Journal Article] Overexpression of Cytotoxic T-Lymphocyte–Associated Antigen-4 Prevents Atherosclerosis in Mice2016
- Author(s)
  Takuya Matsumoto, Naoto Sasaki, Tomoya Yamashita, Takuo Emoto, Kazuyuki Kasahara, Taiji Mizoguchi, Tomohiro Hayashi, Keiko Yodoi, Naoki kitano, Takashi Saito, Tomoyuki Yamaguchi, and Ken-ichi Hirata
- Journal Title
  
  Arterioscler Thromb Vasc Biol.
  
  Volume : 36 Pages : 1141-51
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08530, KAKENHI-PROJECT-24229004, KAKENHI-PROJECT-15K09156, KAKENHI-PROJECT-16K09516
[Journal Article] SH3 domain of c-Src governs its dynamics at focal adhesions and the cell membrane2015
- Author(s)
  Machiyama H, Yamaguchi T, Sawada Y, Watanabe T, Fujita H
- Journal Title
  
  FEBS Journal
  
  Volume : 282 Pages : 4034-4055
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08530, KAKENHI-PLANNED-23115002, KAKENHI-PROJECT-26291028
[Journal Article] Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon.2012
- Author(s)
  Kinoshita M, Kayama H, Kusu T, Yamaguchi T, Kunisawa J, Kiyono H, Sakaguchi S, Takeda K.
- Journal Title
  
  J Immunol.
  
  Volume : 189 Pages : 2869-78
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Two modes of immune suppression by Foxp3(十) regulatory T cells under inflammatory or non-inflammatory conditions2012
- Author(s)
  Yamaguchi, T., Wing, J.B., Sakaguchi, S.
- Journal Title
  
  Semin Immunol
  
  Volume : 23 Pages : 424-430
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon2012
- Author(s)
  Kinoshita M, Kayama H, Kusu T, Yamaguchi T, Kunisawa J, Kiyono H, Sakaguchi S, Takeda K
- Journal Title
  
  J Immunol
  
  Volume : 189 Pages : 2869-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo2011
- Author(s)
  Satou, Y., Yasunaga, J., Zhao, T., Yoshida, M., Miyazato, P., Takai, K., Shimizu, K., Ohshima, K., Green, P.L., Ohkura, N., Yamaguchi, T., Ono, M., Sakaguchi, S., Matsuoka, M.
- Journal Title
  
  PLoS Pathog
  
  Volume : 7(2)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Cell-autonomous and -nonautonomous functions of CTLA-4 for negative control of immune responses2011
- Author(s)
  Wing, K., Yamaguchi, T, Sakaguchi, S.
- Journal Title
  
  Trends Immunol
  
  Volume : 32 Pages : 428-433
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo.2011
- Author(s)
  Satou, Y., Yasunaga, J., Zhao, T., Yoshida, M., Miyazato, P., Takai, K., Shimizu, K., Ohshima, K., Green, P. L., Ohkura, N., Yamaguchi, T., Ono, M., Sakaguchi, S., Matsuoka, M.
- Journal Title
  
  PLoS Pathog.
  
  Volume : 7(2)
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Two modes of immune suppression by Foxp3(+) regulatory T cells under inflammatory or non-inflammatory conditions2011
- Author(s)
  Yamaguchi, T., Wing, J. B., Sakaguchi, S.
- Journal Title
  
  Semin Immunol.
  
  Volume : 23 Pages : 424-430
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Cell-autonomous and -nonautonomous functions of CTLA-4 for negative control of immune responses2011
- Author(s)
  Wing, K., Yamaguchi, T., Sakaguchi, S.
- Journal Title
  
  Trends Immunol.
  
  Volume : 32 Pages : 428-43
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Multiple antitumor mechanisms downstream of prophylactic regulatory T-cell depletion.2010
- Author(s)
  Teng, M.W., Swann, J.B., von Scheidt B, Sharkey, J., Zerafa, N., McLaughlin, N., Yamaguchi, T., Sakaguchi, S., Darcy, P.K., and Smyth,M.J.
- Journal Title
  
  Cancer Res
  
  Volume : 70 Pages : 2665-2674
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Multiple antitumor mechanisms downstream of prophylactic regulatory T-cell depletion.2010
- Author(s)
  Teng, M.W., Swann, J.B., von Scheidt B, Sharkey, J., Zerafa, N., McLaughlin, N., Yamaguchi, T., Sakaguchi, S., Darcy, P.K., Smyth, M.J.
- Journal Title
  
  Cancer Res. 70
  
  Pages : 2665-2674
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Functional delineation and differentiation dynamics of human CD4(+) T cells expressing the FoxP3 transcription factor.2009
- Author(s)
  Miyara, M., Shima, T., Kitoh, A., Yoshioka, Y., Niwa, A., Taflin, C., Heike, T., Valeyre, D., Mathian, A., Nakahata, T., Yamaguchi T., Nomura, T., Wing, K., Ono, M., Amoura, Z., Gorochov, G., and Sakaguchi, S.
- Journal Title
  
  Immunity
  
  Volume : 30 Pages : 899-911
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Regulatory T cells : how do they suppress immune responses?2009
- Author(s)
  Sakaguchi S, Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T.
- Journal Title
  
  Int. Immunol. 21
  
  Pages : 1105-1111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Dynamics of peripheral tolerance and immune regulation mediated by Treg.2009
- Author(s)
  Sakaguchi, S., Wing, K., Yamaguchi, T.
- Journal Title
  
  Eur. J.Immunol. 39
  
  Pages : 2331-2336
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Indispensable role of in vivo suppressive function of FoxP3+ regulatory T cells.2009
- Author(s)
  Kitoh, A., Ono, M., Naoe, Y., Ohkura, N., Yamaguchi, T, Yaguchi, H., Kitabayashi, I., Tsukada, T., Nomura, T., Miyachi, Y., Taniuchi, I., Sakaguchi, S.
- Journal Title
  
  Immunity. 31
  
  Pages : 609-620
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Functional delineation and differentiation dynamics of human CD4(+) T cells expressing the FoxP3 transcription factor.2009
- Author(s)
  Miyara, M., Shima, T., Kitoh, A., Yoshioka, Y., Niwa, A., Taflin, C., Heike, T., Valeyre, D., Mathian, A., Nakahata, T., Yamaguchi T., Nomura, T., Wing, K., Ono, M., Amoura, Z., Gorochov, G., Sakaguchi, S.
- Journal Title
  
  Immunity. 30
  
  Pages : 899-911
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Indispensable role of Runxl/Cbf complexes for in vivo suppressive function of FoxP^<3+> regulatory T cells.2009
- Author(s)
  Kitoh, A., Ono, M., Naoe, Y., Ohkura, N., Yamaguchi, T, Yaguchi H., Kitabayashi, I., Tsukada, T., Nomura, T., Miyachi,Y., Taniuchi, I., Sakaguchi, S.
- Journal Title
  
  Immunity. 31
  
  Pages : 609-620
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Functional delineation and differentiation dynamics of human CD4(+) Tcells expressing the FoxP3 transcription factor.2009
- Author(s)
  Miyara, M., Shima, T., Kitoh, A., Yoshioka, Y., Niwa, A., Taflin, C., Heike, T., Valeyre, D., Mathian, A., Nakahata, T., Yamaguchi T., Nomura, T., Wing, K., Ono, M., Amoura, Z., Guy Gorochov, G., Sakaguchi, S.
- Journal Title
  
  Immunity. 30
  
  Pages : 899-911
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Dynamics of peripheral tolerance and immune regulation mediated by Treg2009
- Author(s)
  Sakaguchi, S., Wing, K., and Yamaguchi, T.
- Journal Title
  
  Eur. J. Immunol
  
  Volume : 39 Pages : 2331-6
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Indispensable role of Runx1/Cbf・complexes for in vivo suppressive function of FoxP3+regulatory T cells2009
- Author(s)
  Kitoh, A., Ono, M., Naoe, Y., Ohkura, N., Yamaguchi, T, Yaguchi, H., Kitabayashi, I., Tsukada, T., Nomura, T., Miyachi,Y., Taniuchi, I., and Sakaguchi, S.
- Journal Title
  
  Immunity.
  
  Volume : 31 Pages : 609-620
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] CTLA-4 control over Foxp3+regulatory T cell function2008
- Author(s)
  Wing, K., Onishi, Y., Prieto-Martin, P., Yamaguchi, T., Miyara, M., Fehervari, Z., Nomura, T., and Sakaguchi, S.
- Journal Title
  
  Science.
  
  Volume : 322 Pages : 271-275
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Foxp3+natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation.2008
- Author(s)
  Onishi, Y., Fehervari, Z., Yamaguchi, T., and Sakaguchi, S
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume : 29 Pages : 10113-10118
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Regulatory T cells and immune tolerance2008
- Author(s)
  Sakaguchi, S., Yamaguchi, T., Nomura, T., and Ono, M.
- Journal Title
  
  Cell
  
  Volume : 133 Pages : 775-787
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Foxp^<3+> natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation2008
- Author(s)
  Onishi, Y., Fehervari, Z., Yamaguchi, T., and Sakaguchi. S.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA. 29
  
  Pages : 10113-10118
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] CTLA-4 control over Foxp3^+regulatory T cell funtion2008
- Author(s)
  Wing, K., Onishi, Y., Prieto-Martin, P., Yamaguchi, T., Miyara, M.
- Journal Title
  
  Science 322
  
  Pages : 271-275
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Regulatory T cell and immune tolerance2008
- Author(s)
  Sakaguchi, S., Yamaguchi, T., and Ono, M
- Journal Title
  
  Cell 133
  
  Pages : 775-787
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation.2008
- Author(s)
  Onishi, Y., Fehervari, Z., Yamaguchi, T., Sakaguchi, S.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA. 29
  
  Pages : 10113-10118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] CTLA-4 control over Foxp3+ regulatory T cell function.2008
- Author(s)
  Wing, K., Onishi, Y., Prieto-Martin, P., Yamaguchi, T., Miyara, M., Fehervari, Z., Nomura, T., Sakaguchi, S.
- Journal Title
  
  Science. 322
  
  Pages : 271-275
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Construction of self-recognizing regulatory T cells from conventional T cells by controllingCTLA-4 and IL-2 expression.
- Author(s)
  Yamaguchi T, Kishi A, Osaki M, Morikawa H, Prieto-Martin P, Wing K, Saito T, and Sakaguchi S.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume : (In press)
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Control of immune response based on a theoretical model of T cell proliferation2016
- Author(s)
  山口　智之
- Organizer
  The 45th Annual meeting of the japanese society for immunology
- Place of Presentation
  沖縄県　宜野湾市　沖縄コンベンションセンター
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08530
[Presentation] Modeling for immune regulation2015
- Author(s)
  Tomoyuki Yamaguchi
- Organizer
  QBiC Symposium 2015
- Place of Presentation
  RIKEN Quantitative Biology Center
- Year and Date
  2015-08-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08530
[Presentation] Construction of regulatory T cells without FoxP3.2010
- Author(s)
  T.Yamaguchi, A.Kishi, M.Osaki, S.Sakaguchi
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20002007

1. SAKAGUCHI Shimon (30280770)

# of Collaborated Projects : 1results

# of Collaborated Products : 28results
2. OHKURA Naganari (20300949)

# of Collaborated Projects : 1results

# of Collaborated Products : 5results
3. NISHIKAWA Hiroyoshi (10444431)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
4. ITO Yoshinaga (60614013)

# of Collaborated Projects : 1results

# of Collaborated Products : 7results
5. KONDO Gen (40243258)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
6. KITABAYASHI Issei (20261175)

# of Collaborated Projects : 1results

# of Collaborated Products : 3results
7. TANIUCHI Ichiro (20284573)

# of Collaborated Projects : 1results

# of Collaborated Products : 3results
8. WATANABE Tomonobu

# of Collaborated Projects : 0results

# of Collaborated Products : 2results
9. FUJITA Katsumasa

# of Collaborated Projects : 0results

# of Collaborated Products : 2results
10. Chiu Liang-da

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
11. 市村垂生

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
12. 斉藤隆

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
13. 佐々木直人

# of Collaborated Projects : 0results

# of Collaborated Products : 2results
14. 山下智也

# of Collaborated Projects : 0results

# of Collaborated Products : 2results

YAMAGUCHI Tomoyuki 山口 智之

Research Projects

Research Products

Co-Researchers

免疫制御機構についての理論・実験の融合的研究Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular basis of the function and generation of Foxp3-expressing regulatory T cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Non-label immune cell state prediction using Raman spectroscopy2017

Author(s)

Journal Title

Data Source

[Journal Article] UVB Exposure Prevents Atherosclerosis by Regulating Immunoinflammatory Responses.2017

Author(s)

Journal Title

Data Source

[Journal Article] Robust and Accurate Discrimination of Self/Non-Self Antigen Presentations by Regulatory T Cell Suppression.2016

Author(s)

Journal Title

Data Source

[Journal Article] Overexpression of Cytotoxic T-Lymphocyte&#8211;Associated Antigen-4 Prevents Atherosclerosis in Mice2016

Author(s)

Journal Title

Data Source

[Journal Article] SH3 domain of c-Src governs its dynamics at focal adhesions and the cell membrane2015

Author(s)

Journal Title

Data Source

[Journal Article] Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon.2012

Author(s)

Journal Title

Data Source

[Journal Article] Two modes of immune suppression by Foxp3(十) regulatory T cells under inflammatory or non-inflammatory conditions2012

Author(s)

Journal Title

Data Source

[Journal Article] Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon2012

Author(s)

Journal Title

Data Source

[Journal Article] HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo2011

Author(s)

Journal Title

Data Source

[Journal Article] Cell-autonomous and -nonautonomous functions of CTLA-4 for negative control of immune responses2011

Author(s)

Journal Title

Data Source

[Journal Article] HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo.2011

Author(s)

Journal Title

Data Source

[Journal Article] Two modes of immune suppression by Foxp3(+) regulatory T cells under inflammatory or non-inflammatory conditions2011

Author(s)

Journal Title

Data Source

[Journal Article] Cell-autonomous and -nonautonomous functions of CTLA-4 for negative control of immune responses2011

Author(s)

Journal Title

Data Source

[Journal Article] Multiple antitumor mechanisms downstream of prophylactic regulatory T-cell depletion.2010

Author(s)

Journal Title

Data Source

[Journal Article] Multiple antitumor mechanisms downstream of prophylactic regulatory T-cell depletion.2010

Author(s)

Journal Title

Data Source

[Journal Article] Functional delineation and differentiation dynamics of human CD4(+) T cells expressing the FoxP3 transcription factor.2009

Author(s)

Journal Title

Data Source

YAMAGUCHI Tomoyuki 山口智之

[Journal Article] Overexpression of Cytotoxic T-Lymphocyte–Associated Antigen-4 Prevents Atherosclerosis in Mice2016