• Search Research Projects
  • Search Researchers
  1. Back to previous page

YAMAGUCHI Tomoyuki  山口 智之

ORCIDConnect your ORCID iD *help
Researcher Number 80402791
Other IDs
Affiliation *help 2017 – 2018 : 医療法人徳洲会野崎徳洲会病院(附属研究所), 研究所, 主任研究員
2016 : 大阪大学, 免疫学フロンティア研究センター, 特任准教授(常勤)
2015 : 大阪大学, 免疫学フロンティア研究センター, 特任准教授
2011 – 2012 : 大阪大学, 免疫学フロンティア研究センター, 特任准教授
2008 – 2010 : 京都大学, 再生医科学研究所, 助教
Review Section/Research Field
Principal Investigator
Immunology
Except Principal Investigator
Biological Sciences
Keywords
Principal Investigator
免疫寛容 / 制御性T細胞 / 多様性 / 免疫制御モデル / 数理モデル / 選択的増殖
Except Principal Investigator
Tリンパ球 / FOXP3 / CTLA-4 / 制御性T細胞 … More / 自己免疫病 / T細胞抗原レセプター / 免疫制御 / 制御性T細胞 / Tリンパ球 / エピゲノム / T細胞抗原レセプター Less
  • Research Projects

    (2results)
  • Research Products

    (39results)
  • Co-Researchers

    (16People)
  •  Theoretical and experimental analyses to reveal the mechanisms of immune regulationPrincipal Investigator

    • Principal Investigator
      山口 智之
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      382661
      Osaka University
  •  Molecular basis of the function and generation of Foxp3-expressing regulatory T cells

    • Principal Investigator
      SAKAGUCHI Shimon
    • Project Period (FY)
      2008 – 2012
    • Research Category
      Grant-in-Aid for Specially Promoted Research
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University
      Kyoto University

All 2018 2017 2016 2015 2012 2011 2010 2009 2008 Other

All Journal Article Presentation

  • [Journal Article] Non-label immune cell state prediction using Raman spectroscopy2017

    • Author(s)
      Taro Ichimura, Liang-da Chiu, Katsumasa Fujita, Hiroaki Machiyama, Tomoyuki Yamaguchi, Tomonobu M. Watanabe, Hideaki Fujita
    • Journal Title

      Sci. Rep.

      Volume : 6 Pages : 37562-37562

    • DOI
      10.1038/srep37562
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K19128, KAKENHI-PUBLICLY-16H01439, KAKENHI-PROJECT-26286063, KAKENHI-PROJECT-15K20950, KAKENHI-PROJECT-15K08530, KAKENHI-PROJECT-16K14717, KAKENHI-PROJECT-26291028
  • [Journal Article] UVB exposure prevents atherosclerosis by regulating immunoinflammatory responses.2017

    • Author(s)
      Sasaki, N., T. Yamashita, K. Kasahara, A. Fukunaga, T. Yamaguchi, T. Emoto, K. Yodoi, T. Matsumoto, K. Nakajima, T. Kita, M. Takeda, T. Mizoguchi, T. Hayashi, Y. Sasaki, M. Hatakeyama, K. Taguchi, K. Washio, S. Sakaguchi, B. Malissen, C. Nishigori, and K.I. Hirata
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume : 37(1) Pages : 66-74

    • DOI
      10.1161/atvbaha.116.308063
    • Peer Reviewed / Int'l Joint Research / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K08530, KAKENHI-PROJECT-15K09156, KAKENHI-PROJECT-16K09516, KAKENHI-PROJECT-16H06295, KAKENHI-PROJECT-15K09742
  • [Journal Article] Robust and Accurate Discrimination of Self/Non-Self Antigen Presentations by Regulatory T Cell Suppression2016

    • Author(s)
      Furusawa, C. and T. Yamaguchi
    • Journal Title

      PLoS One

      Volume : 11

    • DOI
      10.1371/journal.pone.0163134
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K08530, KAKENHI-PROJECT-15H05746
  • [Journal Article] Overexpression of Cytotoxic T-Lymphocyte-Associated Antigen-4 Prevents Atherosclerosis in Mice2016

    • Author(s)
      Takuya Matsumoto, Naoto Sasaki, Tomoya Yamashita, Takuo Emoto, Kazuyuki Kasahara, Taiji Mizoguchi, Tomohiro Hayashi, Keiko Yodoi, Naoki kitano, Takashi Saito, Tomoyuki Yamaguchi, and Ken-ichi Hirata
    • Journal Title

      Arterioscl. Throm. Vasc Biol.

      Volume : 36 Pages : 1141-51

    • DOI
      10.1161/atvbaha.115.306848
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K08530, KAKENHI-PROJECT-24229004, KAKENHI-PROJECT-15K09156, KAKENHI-PROJECT-16K09516
  • [Journal Article] SH3 domain of c-Src governs its dynamics at focal adhesions and the cell membrane.2015

    • Author(s)
      Machiyama H, Yamaguchi T, Sawada Y, Watanabe T, Fujita H
    • Journal Title

      FEBS Journal

      Volume : 282 Pages : 4034-4055

    • DOI
      10.1111/febs.13404
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K08530, KAKENHI-PLANNED-23115002, KAKENHI-PROJECT-26291028
  • [Journal Article] Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon.2012

    • Author(s)
      Kinoshita M, Kayama H, Kusu T, Yamaguchi T, Kunisawa J, Kiyono H, Sakaguchi S, Takeda K.
    • Journal Title

      J Immunol.

      Volume : 189 Pages : 2869-78

    • Data Source
      KAKENHI-PROJECT-20002007
  • [Journal Article] Two modes of immune suppression by Foxp3(十) regulatory T cells under inflammatory or non-inflammatory conditions2012

    • Author(s)
      Yamaguchi, T., Wing, J.B., Sakaguchi, S.
    • Journal Title

      Semin Immunol

      Volume : 23 Pages : 424-430

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20002007
  • [Journal Article] Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon2012

    • Author(s)
      Kinoshita M, Kayama H, Kusu T, Yamaguchi T, Kunisawa J, Kiyono H, Sakaguchi S, Takeda K
    • Journal Title

      J Immunol

      Volume : 189 Pages : 2869-78

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20002007
  • [Journal Article] HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo2011

    • Author(s)
      Satou, Y., Yasunaga, J., Zhao, T., Yoshida, M., Miyazato, P., Takai, K., Shimizu, K., Ohshima, K., Green, P.L., Ohkura, N., Yamaguchi, T., Ono, M., Sakaguchi, S., Matsuoka, M.
    • Journal Title

      PLoS Pathog

      Volume : 7(2)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20002007
  • [Journal Article] Cell-autonomous and -nonautonomous functions of CTLA-4 for negative control of immune responses2011

    • Author(s)
      Wing, K., Yamaguchi, T, Sakaguchi, S.
    • Journal Title

      Trends Immunol

      Volume : 32 Pages : 428-433

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20002007
  • [Journal Article] HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo.2011

    • Author(s)
      Satou, Y., Yasunaga, J., Zhao, T., Yoshida, M., Miyazato, P., Takai, K., Shimizu, K., Ohshima, K., Green, P. L., Ohkura, N., Yamaguchi, T., Ono, M., Sakaguchi, S., Matsuoka, M.
    • Journal Title

      PLoS Pathog.

      Volume : 7(2)

    • Data Source
      KAKENHI-PROJECT-20002007
  • [Journal Article] Two modes of immune suppression by Foxp3(+) regulatory T cells under inflammatory or non-inflammatory conditions2011

    • Author(s)
      Yamaguchi, T., Wing, J. B., Sakaguchi, S.
    • Journal Title

      Semin Immunol.

      Volume : 23 Pages : 424-430

    • Data Source
      KAKENHI-PROJECT-20002007
  • [Journal Article] Cell-autonomous and -nonautonomous functions of CTLA-4 for negative control of immune responses2011

    • Author(s)
      Wing, K., Yamaguchi, T., Sakaguchi, S.
    • Journal Title

      Trends Immunol.

      Volume : 32 Pages : 428-43

    • Data Source
      KAKENHI-PROJECT-20002007
  • [Journal Article] Multiple antitumor mechanisms downstream of prophylactic regulatory T-cell depletion.2010

    • Author(s)
      Teng, M.W., Swann, J.B., von Scheidt B, Sharkey, J., Zerafa, N., McLaughlin, N., Yamaguchi, T., Sakaguchi, S., Darcy, P.K., and Smyth,M.J.
    • Journal Title

      Cancer Res

      Volume : 70 Pages : 2665-2674

    • Data Source
      KAKENHI-PROJECT-20002007
  • [Journal Article] Multiple antitumor mechanisms downstream of prophylactic regulatory T-cell depletion.2010

    • Author(s)
      Teng, M.W., Swann, J.B., von Scheidt B, Sharkey, J., Zerafa, N., McLaughlin, N., Yamaguchi, T., Sakaguchi, S., Darcy, P.K., Smyth, M.J.
    • Journal Title

      Cancer Res. 70

      Pages : 2665-2674

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20002007
  • [Journal Article] Functional delineation and differentiation dynamics of human CD4(+) T cells expressing the FoxP3 transcription factor.2009

    • Author(s)
      Miyara, M., Shima, T., Kitoh, A., Yoshioka, Y., Niwa, A., Taflin, C., Heike, T., Valeyre, D., Mathian, A., Nakahata, T., Yamaguchi T., Nomura, T., Wing, K., Ono, M., Amoura, Z., Gorochov, G., and Sakaguchi, S.
    • Journal Title

      Immunity

      Volume : 30 Pages : 899-911

    • Data Source
      KAKENHI-PROJECT-20002007
  • [Journal Article] Regulatory T cells : how do they suppress immune responses?2009

    • Author(s)
      Sakaguchi S, Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T.
    • Journal Title

      Int. Immunol. 21

      Pages : 1105-1111

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20002007
  • [Journal Article] Dynamics of peripheral tolerance and immune regulation mediated by Treg.2009

    • Author(s)
      Sakaguchi, S., Wing, K., Yamaguchi, T.
    • Journal Title

      Eur. J.Immunol. 39

      Pages : 2331-2336

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20002007
  • [Journal Article] Indispensable role of in vivo suppressive function of FoxP3+ regulatory T cells.2009

    • Author(s)
      Kitoh, A., Ono, M., Naoe, Y., Ohkura, N., Yamaguchi, T, Yaguchi, H., Kitabayashi, I., Tsukada, T., Nomura, T., Miyachi, Y., Taniuchi, I., Sakaguchi, S.
    • Journal Title

      Immunity. 31

      Pages : 609-620

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20002007
  • [Journal Article] Functional delineation and differentiation dynamics of human CD4(+) T cells expressing the FoxP3 transcription factor.2009

    • Author(s)
      Miyara, M., Shima, T., Kitoh, A., Yoshioka, Y., Niwa, A., Taflin, C., Heike, T., Valeyre, D., Mathian, A., Nakahata, T., Yamaguchi T., Nomura, T., Wing, K., Ono, M., Amoura, Z., Gorochov, G., Sakaguchi, S.
    • Journal Title

      Immunity. 30

      Pages : 899-911

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20002007
  • [Journal Article] Indispensable role of Runxl/Cbf complexes for in vivo suppressive function of FoxP^<3+> regulatory T cells.2009

    • Author(s)
      Kitoh, A., Ono, M., Naoe, Y., Ohkura, N., Yamaguchi, T, Yaguchi H., Kitabayashi, I., Tsukada, T., Nomura, T., Miyachi,Y., Taniuchi, I., Sakaguchi, S.
    • Journal Title

      Immunity. 31

      Pages : 609-620

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20002007
  • [Journal Article] Functional delineation and differentiation dynamics of human CD4(+) Tcells expressing the FoxP3 transcription factor.2009

    • Author(s)
      Miyara, M., Shima, T., Kitoh, A., Yoshioka, Y., Niwa, A., Taflin, C., Heike, T., Valeyre, D., Mathian, A., Nakahata, T., Yamaguchi T., Nomura, T., Wing, K., Ono, M., Amoura, Z., Guy Gorochov, G., Sakaguchi, S.
    • Journal Title

      Immunity. 30

      Pages : 899-911

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20002007
  • [Journal Article] Dynamics of peripheral tolerance and immune regulation mediated by Treg2009

    • Author(s)
      Sakaguchi, S., Wing, K., and Yamaguchi, T.
    • Journal Title

      Eur. J. Immunol

      Volume : 39 Pages : 2331-6

    • Data Source
      KAKENHI-PROJECT-20002007
  • [Journal Article] Indispensable role of Runx1/Cbf・complexes for in vivo suppressive function of FoxP3+regulatory T cells2009

    • Author(s)
      Kitoh, A., Ono, M., Naoe, Y., Ohkura, N., Yamaguchi, T, Yaguchi, H., Kitabayashi, I., Tsukada, T., Nomura, T., Miyachi,Y., Taniuchi, I., and Sakaguchi, S.
    • Journal Title

      Immunity.

      Volume : 31 Pages : 609-620

    • Data Source
      KAKENHI-PROJECT-20002007
  • [Journal Article] CTLA-4 control over Foxp3+regulatory T cell function2008

    • Author(s)
      Wing, K., Onishi, Y., Prieto-Martin, P., Yamaguchi, T., Miyara, M., Fehervari, Z., Nomura, T., and Sakaguchi, S.
    • Journal Title

      Science.

      Volume : 322 Pages : 271-275

    • Data Source
      KAKENHI-PROJECT-20002007
  • [Journal Article] Foxp3+natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation.2008

    • Author(s)
      Onishi, Y., Fehervari, Z., Yamaguchi, T., and Sakaguchi, S
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume : 29 Pages : 10113-10118

    • Data Source
      KAKENHI-PROJECT-20002007
  • [Journal Article] Regulatory T cells and immune tolerance2008

    • Author(s)
      Sakaguchi, S., Yamaguchi, T., Nomura, T., and Ono, M.
    • Journal Title

      Cell

      Volume : 133 Pages : 775-787

    • Data Source
      KAKENHI-PROJECT-20002007
  • [Journal Article] CTLA-4 control over Foxp3^+regulatory T cell funtion2008

    • Author(s)
      Wing, K., Onishi, Y., Prieto-Martin, P., Yamaguchi, T., Miyara, M.
    • Journal Title

      Science 322

      Pages : 271-275

    • Data Source
      KAKENHI-PROJECT-20002007
  • [Journal Article] Foxp^<3+> natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation2008

    • Author(s)
      Onishi, Y., Fehervari, Z., Yamaguchi, T., and Sakaguchi. S.
    • Journal Title

      Proc. Natl. Acad. Sci. USA. 29

      Pages : 10113-10118

    • Data Source
      KAKENHI-PROJECT-20002007
  • [Journal Article] Regulatory T cell and immune tolerance2008

    • Author(s)
      Sakaguchi, S., Yamaguchi, T., and Ono, M
    • Journal Title

      Cell 133

      Pages : 775-787

    • Data Source
      KAKENHI-PROJECT-20002007
  • [Journal Article] Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation.2008

    • Author(s)
      Onishi, Y., Fehervari, Z., Yamaguchi, T., Sakaguchi, S.
    • Journal Title

      Proc.Natl.Acad.Sci.USA. 29

      Pages : 10113-10118

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20002007
  • [Journal Article] CTLA-4 control over Foxp3+ regulatory T cell function.2008

    • Author(s)
      Wing, K., Onishi, Y., Prieto-Martin, P., Yamaguchi, T., Miyara, M., Fehervari, Z., Nomura, T., Sakaguchi, S.
    • Journal Title

      Science. 322

      Pages : 271-275

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20002007
  • [Journal Article] Construction of self-recognizing regulatory T cells from conventional T cells by controllingCTLA-4 and IL-2 expression.

    • Author(s)
      Yamaguchi T, Kishi A, Osaki M, Morikawa H, Prieto-Martin P, Wing K, Saito T, and Sakaguchi S.
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume : (In press)

    • Data Source
      KAKENHI-PROJECT-20002007
  • [Presentation] 制御性T細胞による免疫調節機構の 数理モデルとシミュレーション2018

    • Author(s)
      山口智之
    • Organizer
      第2回理論免疫学ワークショップ
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K08530
  • [Presentation] 免疫応答の理論モデルが示す 制御性T細胞の免疫調節機構2018

    • Author(s)
      山口智之
    • Organizer
      第4回病因研究会別府シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K08530
  • [Presentation] A simulation model of immune response predicts essential functions of Treg to maintain immune tolerance2017

    • Author(s)
      YAMAGUCHI Tomoyuki, TAKAHASHI Reiko
    • Organizer
      第46回日本免疫学会学術集会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08530
  • [Presentation] Control of immune response based on a theoretical model of T cell proliferation2016

    • Author(s)
      山口 智之
    • Organizer
      The 45th Annual meeting of the japanese society for immunology
    • Place of Presentation
      沖縄県 宜野湾市 沖縄コンベンションセンター
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08530
  • [Presentation] Modeling for immune regulation2015

    • Author(s)
      Tomoyuki Yamaguchi
    • Organizer
      QBiC Symposium 2015
    • Place of Presentation
      RIKEN Quantitative Biology Center
    • Year and Date
      2015-08-24
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08530
  • [Presentation] Construction of regulatory T cells without FoxP3.2010

    • Author(s)
      T.Yamaguchi, A.Kishi, M.Osaki, S.Sakaguchi
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-20002007
  • 1.  SAKAGUCHI Shimon (30280770)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 29results
  • 2.  OHKURA Naganari (20300949)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 5results
  • 3.  NISHIKAWA Hiroyoshi (10444431)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 4.  ITO Yoshinaga (60614013)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 7results
  • 5.  KONDO Gen (40243258)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 6.  KITABAYASHI Issei (20261175)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 3results
  • 7.  TANIUCHI Ichiro (20284573)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 3results
  • 8.  FUJITA Katsumasa
    # of Collaborated Projects : 0results
    # of Collaborated Products : 2results
  • 9.  渡邉 朋信
    # of Collaborated Projects : 0results
    # of Collaborated Products : 2results
  • 10.  古澤 力
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
  • 11.  斉藤 隆
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
  • 12.  佐々木 直人
    # of Collaborated Projects : 0results
    # of Collaborated Products : 2results
  • 13.  山下 智也
    # of Collaborated Projects : 0results
    # of Collaborated Products : 2results
  • 14.  市村 垂生
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
  • 15.  邱 亮達
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
  • 16.  福永 淳
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results

URL :

Are you sure that you want to connect your ORCID iD to this researcher?

Information FAQ News Terms of Use

Powered by NII kakenhi