Miyazaki Masaki 宮崎正輝

… Alternative Names

宮崎正輝ミヤザキマサキ

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Researcher Number	80403632
Other IDs
Affiliation (Current)	2025: 京都大学, 医生物学研究所, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 京都大学, 医生物学研究所, 准教授 2016 – 2021: 京都大学, ウイルス・再生医科学研究所, 准教授 2009: 広島大, 医歯(薬)学総合研究科, 助教 2008: Hiroshima University, 大学院・医歯薬学総合研究科, 助教
Review Section/Research Field	Principal Investigator Medium-sized Section 49:Pathology, infection/immunology, and related fields / Basic Section 49070:Immunology-related / Immunology / Pathological medical chemistry
Keywords	Principal Investigator T細胞分化 / 転写因子 / エンハンサー調節 / リンパ球分化 / B細胞分化 / エンハンサー / 自然リンパ球 / E2A / 転写制御 / ゲノム構造制御 … More / 遺伝子発現 / 細胞種特異的 / Gene Desert / クロマチン構造制御 / 細胞種特異的な遺伝子発現 / gene desert / エンハンサー制御 / 自然リンパ球分化 / T細胞系列決定 / シングルセルmultiome解析 / Notchシグナル / シングルセル解析 / 免疫応答 / 骨髄 / 胸腺 / 授乳 / 妊娠 / 免疫反応 / T, B細胞分化 / 妊娠・授乳期における免疫細胞分化 / 遺伝子発現制御 / 授乳期 / 免疫寛容 / 3Dゲノム / Regulame / Rag1/Rag2遺伝子 / 3Dゲノム構造制御 / Rag1/Rag2遺伝子発現制御 / 獲得免疫リンパ球分化 / ３次元ゲノム構造 / 転写因子E2A / ３次元ゲノム構造変換 / Rag遺伝子 / 獲得免疫リンパ球 / V(D)J DNA recombination / super-enhancer formation / enhancer regulation / Rag1 and Rag2 expression / T cell and B cell / adaptive lymphocyte / ゲノム構造 / 遺伝子再構成 / T, B細胞 / Rag1 Rag2 / 獲得免疫 / 分化と活性化 / T細胞の分化・活性化 / リンパ腫 / E2A, Id2 / T細胞分化と活性化 / Id2, Id3 / E2A, Id2, Id3 / 分化・活性化 / T細胞 / ポリコーム遺伝子 / エピジェネティック制御 Less

Single cell multiome analyis unveils the regulatory mechanisms of T versus ILC lineage commitmentsPrincipal Investigator
- Principal Investigator
  
  宮崎正輝
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Kyoto University
Functional analysis of Gene Desert as an enhancer reservoir in the establishment of cell lineage commitment and its diversityPrincipal Investigator
- Principal Investigator
  
  宮崎正輝
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Fund for the Promotion of Joint International Research (International Collaborative Research)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Kyoto University
Elucidation of molecular mechanisms of maternal immune tolerancePrincipal Investigator
- Principal Investigator
  
  Miyazaki Masaki
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Kyoto University
The Regulome controls adaptive lymphocyte development and DNA recombinase Rag1/Rag2 expressionPrincipal Investigator
- Principal Investigator
  
  Miyazaki Masaki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Kyoto University
The transcriptional regulation by E-Id protein axis upon T cell activation and its cellular metabolismPrincipal Investigator
- Principal Investigator
  
  Miyazaki Masaki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Kyoto University
ポリコーム遺伝子bmi-1による幼若リンパ球の増殖と細胞死のバランス調節機構Principal Investigator
- Principal Investigator
  
  宮崎正輝
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Hiroshima University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2008

All Journal Article Presentation

[Journal Article] Regulation of lymphoid-myeloid lineage bias through regnase-1/3-mediated control of Nfkbiz2024
- Author(s)
  3.Uehata T, Yamada S, Ori D, Vandenbon A, Giladi A, Jelinski A, Murakawa Y, Watanabe H, Takeuchi K, Toratani K, Mino T, Kiryu H, Standley DM, Tsujimura T, IkawaT, Kondoh G, Landthaler M, Kawamoto H, Rodewald HR, Amit I, Yamamoto R, Miyazaki M, Takeuchi O
- Journal Title
  
  Blood
  
  Volume: 143 Issue: 3 Pages: 243-257
- DOI
  10.1182/blood.2023020903
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KF0209, KAKENHI-PROJECT-23K11299, KAKENHI-PROJECT-20K12059, KAKENHI-PROJECT-22K19430, KAKENHI-PROJECT-22KF0226, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-23H00402, KAKENHI-PROJECT-23K27425
[Journal Article] Liver type 1 innate lymphoid cells lacking IL-7 receptor are a native killer cell subset fostered by parenchymal niches2023
- Author(s)
  Asahi Takuma、Abe Shinya、Cui Guangwei、Shimba Akihiro、Nabekura Tsukasa、Miyachi Hitoshi、Kitano Satsuki、Ohira Keizo、Dijkstra Johannes M、Miyazaki Masaki、Shibuya Akira、Ohno Hiroshi、Ikuta Koichi
- Journal Title
  
  eLife
  
  Volume: 12 Pages: 1-22
- DOI
  10.7554/elife.84209
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07133, KAKENHI-PROJECT-22K19430, KAKENHI-PROJECT-23K27425, KAKENHI-PROJECT-23K27426
[Journal Article] Hematopoietic cell-derived IL-15 supports NK cell development in scattered and clustered localization within the bone marrow2023
- Author(s)
  Abe Shinya、Asahi Takuma、Hara Takahiro、Cui Guangwei、Shimba Akihiro、Tani-ichi Shizue、Yamada Kohei、Miyazaki Kazuko、Miyachi Hitoshi、Kitano Satsuki、Nakamura Naotoshi、Kikuta Junichi、Vandenbon Alexis、Miyazaki Masaki、Yamada Ryo、Ohteki Toshiaki、Ishii Masaru、Sexl Veronika、Nagasawa Takashi、Ikuta Koichi
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 9 Pages: 113127-113127
- DOI
  10.1016/j.celrep.2023.113127
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07133, KAKENHI-PROJECT-21K08370, KAKENHI-PROJECT-22K19430, KAKENHI-PUBLICLY-22H05627, KAKENHI-PROJECT-23K24152, KAKENHI-PROJECT-23K27425, KAKENHI-PROJECT-23K27426
[Journal Article] The E-Id axis specifies adaptive and innate lymphoid lineage cell fates2022
- Author(s)
  Miyazaki Masaki、Miyazaki Kazuko
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 172 Issue: 5 Pages: 259-264
- DOI
  10.1093/jb/mvac068
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19430
[Journal Article] The E-Id Axis Instructs Adaptive Versus Innate Lineage Cell Fate Choice and Instructs Regulatory T Cell Differentiation2022
- Author(s)
  Hidaka Reiko、Miyazaki Kazuko、Miyazaki Masaki
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 13 Pages: 1-12
- DOI
  10.3389/fimmu.2022.890056
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08370, KAKENHI-PROJECT-22K19430
[Journal Article] The Evolution of Rag Gene Enhancers and Transcription Factor E and Id proteins in the Adaptive Immune System.2021
- Author(s)
  Yoshikawa G, Miyazaki K, Ogata H*, Miyazaki M
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 11 Pages: 5888-5888
- DOI
  10.3390/ijms22115888
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03487, KAKENHI-PROJECT-21K08370
[Journal Article] The Interplay Between Chromatin Architecture and Lineage-Specific Transcription Factors and the Regulation of Rag Gene Expression.2021
- Author(s)
  Miyazaki K., Miyazaki M.
- Journal Title
  
  Frontiers in Immunology,
  
  Volume: 12
- DOI
  10.3389/fimmu.2021.659761
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03487, KAKENHI-PROJECT-21K08370
[Journal Article] The transcription factor E2A activates multiple enhancers that drive Rag expression in developing T and B cells2020
- Author(s)
  Miyazaki Kazuko、Watanabe Hitomi、Yoshikawa Genki、Chen Kenian、Hidaka Reiko、Aitani Yuki、Osawa Kai、Takeda Rie、Ochi Yotaro、Tani-ichi Shizue、Uehata Takuya、Takeuchi Osamu、Ikuta Koichi、Ogawa Seishi、Kondoh Gen、Lin Yin C.、Ogata Hiroyuki、Miyazaki Masaki
- Journal Title
  
  Science Immunology
  
  Volume: 5 Issue: 51 Pages: 1455-1455
- DOI
  10.1126/sciimmunol.abb1455
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-19H03487, KAKENHI-PROJECT-19J13775, KAKENHI-PROJECT-18K15185
[Journal Article] The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development2017
- Author(s)
  Miyazaki Masaki、Miyazaki Kazuko、Chen Kenian、Jin Yi、Turner Jacob、Moore Amanda J.、Saito Rintaro、Yoshida Kenichi、Ogawa Seishi、Rodewald Hans-Reimer、Lin Yin C.、Kawamoto Hiroshi、Murre Cornelis
- Journal Title
  
  Immunity
  
  Volume: 46 Issue: 5 Pages: 818-834.e4
- DOI
  10.1016/j.immuni.2017.04.022
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08629, KAKENHI-PROJECT-16H05205
[Journal Article] Id3 Orchestrates Germinal Center B Cell Development2016
- Author(s)
  Chen Shuwen、Miyazaki Masaki、Chandra Vivek、Fisch Kathleen M.、Chang Aaron N.、Murre Cornelis
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 36 Issue: 20 Pages: 2543-2552
- DOI
  10.1128/mcb.00150-16
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05205
[Presentation] AMPLIFIER CIRCUIT OF E2A-NOTCH1 AXIS ORCHESTRATES T CELL LINEAGE PRIMING, SPECIFICATION, AND COMMITMENT AND SUPPRESSES INNATE LYMPHOID CELL LINEAGE DURING THYMIC ONTOGENY.2023
- Author(s)
  Masaki Miyazaki
- Organizer
  FASEB Science Research Conference
- Data Source
  KAKENHI-PROJECT-23K27425
[Presentation] Amplifier Circuit of E2A-Notch1 Axis Orchestrates T-cell Lineage Priming, Specification, and Commitment and Suppress the ILC Lineage2023
- Author(s)
  Miyazaki Masaki
- Organizer
  日本免疫学会
- Data Source
  KAKENHI-PROJECT-23K27425
[Presentation] To B or not to B. That is the question.2022
- Author(s)
  宮崎正輝
- Organizer
  第51回日本免疫学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K19430
[Presentation] E2A specifies adaptive immunity by instructing large-scale topological changes for Rag gene super-enhancer formation.2021
- Author(s)
  Masaki Miyazaki
- Organizer
  The 94th Annual Meeting of the Japanese Biochemical Society.
- Invited
- Data Source
  KAKENHI-PROJECT-19H03487
[Presentation] Conserved two E-box sequences neighboring the Rag1-promoter is critically required for the initiation of Rag1 gene expression upon T and B cell lineage commitment; Distinct gene regulation mediated by enhancers and promoter for adaptive immunity2021
- Author(s)
  Masaki Miyazaki
- Organizer
  The 50th Annual Meeting of the Japanese Society for Immunology.
- Data Source
  KAKENHI-PROJECT-19H03487
[Presentation] E2A specifies adaptive immunity by instructing large-scale topological changes for Rag gene super-enhancer formation.2020
- Author(s)
  Masaki Miyazaki.
- Organizer
  Cold Spring Harbor Laboratory Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03487
[Presentation] The establishment of 3D genome structure for Rag1/Rag2 expression mediated by E2A/E-protein enhancer activity2019
- Author(s)
  宮崎　正輝
- Organizer
  第48回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-19H03487
[Presentation] The establishment of 3D genome structure for Rag1/Rag2 expression mediated by E2A/E-protein enhancer activity2019
- Author(s)
  Masaki Miyazaki
- Organizer
  FASEB Science Reserach Conference
- Data Source
  KAKENHI-PROJECT-19H03487
[Presentation] The Indispensable Synergic Role of E2A and Notch signaling upon the T cell lineage commitment.2018
- Author(s)
  Masaki Miyazaki, Kazuko Miyazaki, Kawamoto Hiroshi
- Organizer
  日本免疫学会学術集会シンポジウム
- Data Source
  KAKENHI-PROJECT-16H05205
[Presentation] E-protein Activity Determine the Lineage Choice of Adaptive versus Innate Lymphoid Cell Fate2017
- Author(s)
  Masaki Miyazaki
- Organizer
  FASEB Science Research Conferences
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05205
[Presentation] The E-Id Protein Axis Orchestrates the Cell Lineage Choice of Adaptive versus Innate Lymphoid Cells.2017
- Author(s)
  Masaki Miyazaki
- Organizer
  The 46th Annual Meeting of the Japanese Society for Immunology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05205
[Presentation] Thymocyte Development and Cell Death Restraint Mediated by Polycomb Genes2008
- Author(s)
  宮崎正輝
- Organizer
  第31回日本分子生物学会・第81回日本生化学会合同大会
- Place of Presentation
  神戸市
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-20790258
[Presentation] Polycomb gene product Bmi-1 regulates thymocyte development through repression of Ink4 a/Arf locus2008
- Author(s)
  宮崎正輝
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都市
- Year and Date
  2008-10-11
- Data Source
  KAKENHI-PROJECT-20790258

1. 秋山泰身 (50327665)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 堀江健太 (90983528)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Miyazaki Kazuko

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. 榛葉旭恒

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. 村川泰裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 竹内理

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 植畑拓也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 中舛和子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Miyazaki Masaki 宮崎 正輝

宮崎 正輝 ミヤザキ マサキ

Research Projects

Research Products

Co-Researchers

Single cell multiome analyis unveils the regulatory mechanisms of T versus ILC lineage commitmentsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis of Gene Desert as an enhancer reservoir in the establishment of cell lineage commitment and its diversityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of molecular mechanisms of maternal immune tolerancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The Regulome controls adaptive lymphocyte development and DNA recombinase Rag1/Rag2 expressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The transcriptional regulation by E-Id protein axis upon T cell activation and its cellular metabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ポリコーム遺伝子bmi-1による幼若リンパ球の増殖と細胞死のバランス調節機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Regulation of lymphoid-myeloid lineage bias through regnase-1/3-mediated control of Nfkbiz2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Liver type 1 innate lymphoid cells lacking IL-7 receptor are a native killer cell subset fostered by parenchymal niches2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hematopoietic cell-derived IL-15 supports NK cell development in scattered and clustered localization within the bone marrow2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The E-Id axis specifies adaptive and innate lymphoid lineage cell fates2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The E-Id Axis Instructs Adaptive Versus Innate Lineage Cell Fate Choice and Instructs Regulatory T Cell Differentiation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Evolution of Rag Gene Enhancers and Transcription Factor E and Id proteins in the Adaptive Immune System.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Interplay Between Chromatin Architecture and Lineage-Specific Transcription Factors and the Regulation of Rag Gene Expression.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The transcription factor E2A activates multiple enhancers that drive Rag expression in developing T and B cells2020

Author(s)

Journal Title

DOI

Miyazaki Masaki 宮崎正輝

宮崎正輝ミヤザキマサキ