IMAI TAKAYUKI 今井隆之

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今井隆之イマイタカユキ

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Researcher Number	80408583
Affiliation (Current)	2025: 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), 頭頚部外科, 医療部長 2025: 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 特任研究員
Affiliation (based on the past Project Information) *help	2017 – 2023: 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 特任研究員 2013 – 2016: 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん先進治療開発研究部, 特任研究員
Review Section/Research Field	Principal Investigator Otorhinolaryngology / Basic Section 56050:Otorhinolaryngology-related Except Principal Investigator Basic Section 56050:Otorhinolaryngology-related
Keywords	Principal Investigator CD271 / 頭頸部癌 / 下咽頭癌 / 癌幹細胞 / 下咽頭がん / 扁平上皮がん / 細胞増殖 / CDKN1C / 頭頚部癌 / 扁平上皮癌 … More / 頭頸部がん / 頭頚部外科学 / 頭頸部扁平上皮癌 / 癌 … More Except Principal Investigator 頭頚部癌 / 細胞増殖 / 頭頸部癌 / 下咽頭癌 / 扁平上皮癌 / CD271 / がん幹細胞 / 下咽頭がん / 頭頸部がん Less

Role of CD271 in hypopharyngeal cancerPrincipal Investigator
- Principal Investigator
  
  Imai Takayuki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
The tumor initiating cell asa new therapeutic target for hypopharyngeal cancer.
- Principal Investigator
  
  Mochizuki Mai
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Role of CDKN1C in hypopharyngeal cancerPrincipal Investigator
- Principal Investigator
  
  Imai Takayuki
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Survival mechanism of CD271-positive HNSCC and itstherapeutic interventionPrincipal Investigator
- Principal Investigator
  
  IMAI TAKAYUKI
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
CD271+ cancer stem cells: a novel therapeutic target of head and neck squamous cell carcinomaPrincipal Investigator
- Principal Investigator
  
  IMAI TAKAYUKI
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center

All 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Establishment of a Monoclonal Antibody That Recognizes Cysteine-Rich Domain 1 of Human CD2712020
- Author(s)
  Morita Shinkichi、Mochizuki Mai、Shibuya-Takahashi Rie、Nakamura-Shima Mao、Yamazaki Tomoko、Imai Takayuki、Asada Yukinori、Matsuura Kazuto、Kawamura Sadafumi、Yamaguchi Kazunori、Yasuda Jun、Sugamura Kazuo、Katori Yukio、Satoh Kennichi、Tamai Keiichi
- Journal Title
  
  Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
  
  Volume: 39 Issue: 1 Pages: 6-11
- DOI
  10.1089/mab.2019.0040
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09334, KAKENHI-PROJECT-18K09363, KAKENHI-PROJECT-18K16432, KAKENHI-PROJECT-19K16816, KAKENHI-PROJECT-17K07193, KAKENHI-PROJECT-17K11166, KAKENHI-PROJECT-17K11414, KAKENHI-PROJECT-19K08430, KAKENHI-PROJECT-19K09295, KAKENHI-PROJECT-19K09903
[Journal Article] Humanized anti-CD271 monoclonal antibody exerts an anti-tumor effect by depleting cancer stem cells2019
- Author(s)
  Morita Shinkichi、Mochizuki Mai、Wada Kouichi、Shibuya Rie、Nakamura Mao、Yamaguchi Kazunori、Yamazaki Tomoko、Imai Takayuki、Asada Yukinori、Matsuura Kazuto、Sugamura Kazuo、Katori Yukio、Satoh Kennichi、Tamai Keiichi
- Journal Title
  
  Cancer Letters
  
  Volume: 461 Pages: 144-152
- DOI
  10.1016/j.canlet.2019.07.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09363
[Journal Article] CD271 is a negative prognostic factor and essential for cell proliferation in lung squamous cell carcinoma2019
- Author(s)
  Mochizuki Mai、Nakamura Mao、Sibuya Rie、Okazaki Toshimasa、Abe Jiro、Nakagawa Takayuki、Takahashi Satomi、Yamazaki Tomoko、Imai Takayuki、Takano Atsushi、Ito Hiroyuki、Yokose Tomoyuki、Miyagi Yohei、Daigo Yataro、Sato Ikuro、Satoh Kennichi、Sugamura Kazuo、Yamaguchi Kazunori、Tamai Keiichi
- Journal Title
  
  Laboratory Investigation
  
  Volume: - Issue: 9 Pages: 1349-1362
- DOI
  10.1038/s41374-019-0246-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15035, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-18K09363, KAKENHI-PROJECT-19K07884, KAKENHI-PROJECT-19H03559, KAKENHI-PROJECT-16K07187
[Journal Article] Risk factors for cervical lymph node metastasis in endoscopically resected superficial hypopharyngeal cancers2019
- Author(s)
  Imai Takayuki、Ito Shigemi、Oikawa Tomoyuki、Asada Yukinori、Matsumoto Ko、Miyazaki Takefumi、Yamazaki Tomoko、Satoh Ikuro、Noguchi Tetsuya、Matsuura Kazuto
- Journal Title
  
  Auris Nasus Larynx
  
  Volume: 46 Issue: 3 Pages: 424-430
- DOI
  10.1016/j.anl.2018.09.005
- NAID
  130007895065
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11414, KAKENHI-PROJECT-17K07231
[Journal Article] Enhanced Recovery After Surgery program with dexamethasone administration for major head and neck surgery with free tissue transfer reconstruction: initial institutional experience2018
- Author(s)
  Imai Takayuki、Kurosawa Koreyuki、Yamaguchi Kayo、Satake Naoko、Asada Yukinori、Matsumoto Ko、Morita Sinkichi、Saijo Satoshi、Aoi Jiro、Fujii Keitaro、Kishimoto Kazuhiro、Goto Takahiro、Matsuura Kazuto
- Journal Title
  
  Acta Oto-Laryngologica
  
  Volume: 138 Issue: 7 Pages: 664-669
- DOI
  10.1080/00016489.2018.1429651
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11414
[Journal Article] 唾液腺腫瘍の治療方針2018
- Author(s)
  今井隆之，松浦一登
- Journal Title
  
  JHONS
  
  Volume: 34(4) Pages: 437-440
- Data Source
  KAKENHI-PROJECT-17K11414
[Journal Article] Laryngeal function-preserving operation for T4a laryngeal cancer with vocal cord paralysis ? A case report2018
- Author(s)
  Asada Yukinori、Kurosawa Koreyuki、Matsumoto Ko、Goto Takahiro、Katoh Kengo、Imai Takayuki、Saijo Shigeru、Matsuura Kazuto
- Journal Title
  
  Auris Nasus Larynx
  
  Volume: 45 Issue: 1 Pages: 194-199
- DOI
  10.1016/j.anl.2017.03.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10830, KAKENHI-PROJECT-17K11414
[Journal Article] A Novel Funnel-Shaped Flap for Reconstruction Surgery after Total Laryngopharyngectomy with Total Glossectomy2017
- Author(s)
  Kurosawa Koreyuki、Asada Yukinori、Matsumoto Ko、Imai Takayuki、Matsuura Kazuto、Goto Takahiro
- Journal Title
  
  Plastic and Reconstructive Surgery - Global Open
  
  Volume: 5 Issue: 9 Pages: e1504-e1504
- DOI
  10.1097/gox.0000000000001504
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10830, KAKENHI-PROJECT-17K11414
[Journal Article] 下咽頭癌における癌幹細胞表面マーカーの同定とその機能解析2017
- Author(s)
  今井隆之，望月麻衣，森田真吉，西條聡，玉井恵一，松浦一登
- Journal Title
  
  頭頸部癌
  
  Volume: 43 Pages: 339-344
- NAID
  130006219673
- Data Source
  KAKENHI-PROJECT-17K11414
[Journal Article] Clear cell carcinoma of the nasal cavity: A case report from histopathological viewpoint.2016
- Author(s)
  Takayuki Imai, Ikuro Satoh, Ko Matsumoto, Shigemi Ito, Yukinori Asada, Kengo Kato, Yasutoshi Koshiba, Shigeru Saijo, Kazuto Matsuura
- Journal Title
  
  Auris Nasus Larynx
  
  Volume: 43(1) Issue: 1 Pages: 108-11
- DOI
  10.1016/j.anl.2015.06.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K14387, KAKENHI-PROJECT-15K20238
[Journal Article] CD271 regulates the proliferation and motility of hypopharyngeal cancer cells2016
- Author(s)
  Mochizuki M, Tamai K, Imai T, Sugawara S, Ogama N, Nakamura M, Matsuura K, Yamaguchi K, Satoh K, Sato I, Motohashi H, Sugamura K, Tanaka N
- Journal Title
  
  Sci Reｐ
  
  Volume: 6 Issue: 1 Pages: 30707-30707
- DOI
  10.1038/srep30707
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04692, KAKENHI-PROJECT-15K14414, KAKENHI-PROJECT-16K15228, KAKENHI-PROJECT-15K20238, KAKENHI-PROJECT-15K06848, KAKENHI-PROJECT-15K10830, KAKENHI-PROJECT-16K20290
[Journal Article] Effect of HMB/Arg/Gln on the prevention of radiation dermatitis in head and neck cancer patients treated with concurrent chemoradiotherapy.2014
- Author(s)
  T. Imai, K. Matsuura, Y. Asada, S. Sagai, K. Katagiri, E. Ishida, D. Saito, R. Sadayasu, H. Wada and S. Saijo
- Journal Title
  
  Jpn J Clin Oncol
  
  Volume: 44 Issue: 5 Pages: 422-427
- DOI
  10.1093/jjco/hyu027
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24592613, KAKENHI-PROJECT-25462673, KAKENHI-PROJECT-25861603
[Journal Article] CD271 Defines a Stem Cell-Like Population in Hypopharyngeal Cancer2013
- Author(s)
  Imai T
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 4 Pages: e62002-e62002
- DOI
  10.1371/journal.pone.0062002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590713, KAKENHI-PROJECT-23592521, KAKENHI-PROJECT-24300326, KAKENHI-PROJECT-24570142, KAKENHI-PROJECT-24592613, KAKENHI-PROJECT-25860572, KAKENHI-PROJECT-25861603
[Presentation] 神経成長因子受容体CD271は扁平上皮癌の増殖を制御する2019
- Author(s)
  望月麻衣、森田真吉、今井隆之、山口壹範、菅村和夫、玉井恵一
- Organizer
  第92回日本生化学会
- Data Source
  KAKENHI-PROJECT-18K09363
[Presentation] 神経成長因子受容体CD271は扁平上皮がんの増殖制御因子である2019
- Author(s)
  望月麻衣、森田真吉、今井隆之、山口壹範、菅村和夫、玉井恵一
- Organizer
  第42回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-18K09363
[Presentation] 頭頸部癌においてCD271は増殖点浸潤を制御する2016
- Author(s)
  望月麻衣　玉井恵一　今井隆之　小鎌直子　中村真央　松浦一登　山口臺範　佐藤賢一　佐藤郁郎　菅村和夫　田中伸幸
- Organizer
  日本分子生物学会
- Place of Presentation
  横浜市
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-15K20238
[Presentation] Functional Analysis of Hypopharyngeal CSCs marker CD271, focused on migration and invasion.2015
- Author(s)
  Takayuki Imai, Mai Mochizuki
- Organizer
  4th Congress of ASHNO, and 39th annual meeting of JSHNC
- Place of Presentation
  神戸市
- Year and Date
  2015-06-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20238
[Presentation] 分科会A-1：栄養　栄養管理2014
- Author(s)
  今井隆之
- Organizer
  第8回日本頭頸部がん支持療法研究会
- Place of Presentation
  東京都港区
- Year and Date
  2014-06-14
- Data Source
  KAKENHI-PROJECT-25861603
[Presentation] 下咽頭癌における新規がん幹細胞表面マーカー"CD271"の同定に関する研究2014
- Author(s)
  今井隆之
- Organizer
  第8回頭頸部癌基礎研究会
- Place of Presentation
  東京都江東区有明
- Year and Date
  2014-06-11
- Data Source
  KAKENHI-PROJECT-25861603
[Presentation] 下咽頭癌の新規がん幹細胞表面マーカーの同定：CD2712013
- Author(s)
  今井隆之
- Organizer
  第51回日本癌治療学会
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-25861603
[Presentation] 放射線性皮膚炎と栄養療法2013
- Author(s)
  今井隆之
- Organizer
  第37回頭頸部癌学会学術セミナー
- Place of Presentation
  札幌市
- Invited
- Data Source
  KAKENHI-PROJECT-25861603
[Presentation] 頭頸部癌CCRT皮膚炎に対するアバンドTMを用いた栄養介入と腎機能の検討2013
- Author(s)
  今井隆之
- Organizer
  第51回日本癌治療学会
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-25861603
[Presentation] 下咽頭癌における癌幹細胞表面マーカーCD271の高発現は予後不良因子である
- Author(s)
  今井隆之
- Organizer
  第115回日本耳鼻咽喉科学会学術講演会
- Place of Presentation
  福岡市
- Year and Date
  2014-05-14 – 2014-05-17
- Data Source
  KAKENHI-PROJECT-25861603
[Presentation] 治療抵抗性CD271陽性下咽頭癌幹細胞はinvasive frontに存在する
- Author(s)
  今井隆之
- Organizer
  第38回日本頭頸部癌学会
- Place of Presentation
  東京都江東区
- Year and Date
  2014-06-12 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-25861603

1. MATSUURA Kazuto (70271947)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
2. TANAKA Nobuyuki (60280872)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. Mochizuki Mai (40726303)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. TAMAI Keiichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 佐藤郁郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 伊藤しげみ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 森田真吉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 山崎知子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 本橋ほづみ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

IMAI TAKAYUKI 今井 隆之

今井 隆之 イマイ タカユキ

Research Projects

Research Products

Co-Researchers

Role of CD271 in hypopharyngeal cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The tumor initiating cell asa new therapeutic target for hypopharyngeal cancer.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of CDKN1C in hypopharyngeal cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Survival mechanism of CD271-positive HNSCC and itstherapeutic interventionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

CD271+ cancer stem cells: a novel therapeutic target of head and neck squamous cell carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Establishment of a Monoclonal Antibody That Recognizes Cysteine-Rich Domain 1 of Human CD2712020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Humanized anti-CD271 monoclonal antibody exerts an anti-tumor effect by depleting cancer stem cells2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD271 is a negative prognostic factor and essential for cell proliferation in lung squamous cell carcinoma2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Risk factors for cervical lymph node metastasis in endoscopically resected superficial hypopharyngeal cancers2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Enhanced Recovery After Surgery program with dexamethasone administration for major head and neck surgery with free tissue transfer reconstruction: initial institutional experience2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 唾液腺腫瘍の治療方針2018

Author(s)

Journal Title

Data Source

[Journal Article] Laryngeal function-preserving operation for T4a laryngeal cancer with vocal cord paralysis ? A case report2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Novel Funnel-Shaped Flap for Reconstruction Surgery after Total Laryngopharyngectomy with Total Glossectomy2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 下咽頭癌における癌幹細胞表面マーカーの同定とその機能解析2017

Author(s)

Journal Title

NAID

Data Source

IMAI TAKAYUKI 今井隆之

今井隆之イマイタカユキ

[Presentation] 分科会A-1：栄養　栄養管理2014