Inaguma Shingo 稲熊真悟

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INAGUMA Shingo 稲熊真悟

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Researcher Number	80410786
Other IDs
Affiliation (Current)	2025: 名古屋市立大学, 医薬学総合研究院(医学), 教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 名古屋市立大学, 医薬学総合研究院(医学), 教授 2020: 名古屋市立大学, 医薬学総合研究院(医学), 実験病態病理学教授 2019: 名古屋市立大学, 医薬学総合研究院(医学), 高度医療教育研究センター教授 2010 – 2018: Aichi Medical University, 医学部, 講師 2007 – 2009: Aichi Medical University, 医学部, 助教 2006: 愛知医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Human pathology / Basic Section 49020:Human pathology-related / Experimental pathology Except Principal Investigator Human pathology / Basic Section 49020:Human pathology-related / Gastroenterology
Keywords	Principal Investigator ヘッジホッグ / 膵臓癌 / 大腸癌 / 転写因子 / 癌間質 / CD70 / 細胞増殖 / GLI1 / PBK / 癌間質細胞 … More / Cancer stroma / 悪性形質 / PD-L1 / 浸潤 / CD274 / 軟部腫瘍 / 転移 / 滑膜肉腫 / CXCR4 / アポトーシス / ZIC2 / シグナル伝達 / 分子病理 / Sonic hedgehog / 神経分化成長因子 / 病理学 … More Except Principal Investigator ヘッジホッグ / 膵臓癌 / SIL / 分子病理 / 癌細胞由来エクソソーム / 免疫細胞 / 腫瘍関連線維芽細胞 / 癌微小環境 / テトラスパニン / CD81 / 遺伝子ターゲッティング法 / CRISPR/Cas9 / 細胞増殖能 / 細胞老化 / 内在性遺伝子改変 / CRSPR/Cas9 / TP53遺伝子 / p53アイソフォーム / tumor suppression / cellular senescence / p53beta / delta133p53 / delta40p53 / 肝細胞癌 / p53 isoform / アポトーシス / 細胞周期 / p53β / p53α / 肝癌 / CRSPR/CAS9 / isoform / p53 / DNA複製 / クロマチン制御 / 標的遺伝子 / 転写抑制因子 / DCIS / FAM64A / TSHZ2 / Hedgehog / 遺伝子制御 / 乳癌 / Pak1 / ArhGEF7 / 細胞運動 / SIX3 / 前癌病変 / 癌 / 病理学 / 転移 / 浸潤 / シグナル伝達 Less

CD81発現乳癌のエクソソーム制御を介した悪性形質・癌微小免疫環境調節機構の解析
- Principal Investigator
  
  小村理行
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Nagoya City University
PBKリン酸化標的遺伝子を介した大腸癌悪性形質制御機構の解析と治療応用の可能性Principal Investigator
- Principal Investigator
  
  稲熊真悟
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Nagoya City University
Regulation of the tumor malignant potentials and immune evasion by CD70-positive stromal cells.Principal Investigator
- Principal Investigator
  
  Inaguma Shingo
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Nagoya City University
Malignant potential of PD-L1-positive pancreatic cancer cells. Analysis of the stemness and epithelial to mesenchymal transition.Principal Investigator
- Principal Investigator
  
  Inaguma Shingo
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Nagoya City University
  Aichi Medical University
The analysis of the p53 isoforms in hepatocellular carcinoma cells using endogenous gene modification.
- Principal Investigator
  
  NAKAO HARUHISA
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Aichi Medical University
Downstream of newly identified transcriptional repressor and its role in the progression of non-invasive breast cancer.
- Principal Investigator
  
  KASAI KENJI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Aichi Medical University
Roles of the newly identified GLI1-CXCR4 signaling in synovial sarcoma cells.Principal Investigator
- Principal Investigator
  
  Inaguma Shingo
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Aichi Medical University
Hedgehog signaling molecule SIL regulates the migration and progression of pancreatic ductal adenocarcinoma.
- Principal Investigator
  
  KASAI Kenji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Aichi Medical University
Analysis of the cell growth mechanism by ZIC2 transcription factor in pancreatic cancer cells.Principal Investigator
- Principal Investigator
  
  INAGUMA Shingo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human pathology
- Research Institution
  Aichi Medical University
Roles of SIX3 and SIL in the Hedgehog signaling during pancreatic carcinogenesis.
- Principal Investigator
  
  KASAI Kenji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Aichi Medical University
Roles of HES1 and DEC2, newly identified transcriptional targets of GLI1, in pancreatic carcinogenesis.Principal Investigator
- Principal Investigator
  
  INAGUMA Shingo
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human pathology
- Research Institution
  Aichi Medical University
Roles of the Hedgehog signaling in invasion and metastasis of pancreatic cancer
- Principal Investigator
  
  KASAI Kenji
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Aichi Medical University
膵癌における分子標的治療を目指した神経分化成長因子Shh発現機構の解明Principal Investigator
- Principal Investigator
  
  稲熊真悟
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Aichi Medical University

[Journal Article] Simultaneous Expression of CD70 and POSTN in Cancer-Associated Fibroblasts Predicts Worse Survival of Colorectal Cancer Patients2024
- Author(s)
  Komura Masayuki、Wang Chengbo、Ito Sunao、Kato Shunsuke、Ueki Akane、Ebi Masahide、Ogasawara Naotaka、Tsuzuki Toyonori、Kasai Kenji、Kasugai Kunio、Takiguchi Shuji、Takahashi Satoru、Inaguma Shingo
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 25 Issue: 5 Pages: 2537-2551
- DOI
  10.3390/ijms25052537
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06427, KAKENHI-PROJECT-23K06446
[Journal Article] Characterization of colorectal cancer by hierarchical clustering analyses of five immune cell markers2023
- Author(s)
  Ito Sunao、Koshino Akira、Komura Masayuki、Kato Shunsuke、Otani Takahiro、Wang Chengbo、Ueki Akane、Takahashi Hiroki、Ebi Masahide、Ogasawara Naotaka、Tsuzuki Toyonori、Kasai Kenji、Kasugai Kunio、Takiguchi Shuji、Takahashi Satoru、Inaguma Shingo
- Journal Title
  
  Pathology International
  
  Volume: 74 Issue: 1 Pages: 13-25
- DOI
  10.1111/pin.13391
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K11791, KAKENHI-PROJECT-23K06427, KAKENHI-PROJECT-23K06446
[Journal Article] Stromal POSTN Enhances Motility of Both Cancer and Stromal Cells and Predicts Poor Survival in Colorectal Cancer.2023
- Author(s)
  Ueki A, Komura M, Koshino A, Wang C, Nagao K, Homochi M, Tsukada Y, Ebi M, Ogasawara N, Tsuzuki T, Kasai K, Kasugai K, Takahashi S, Inaguma S.
- Journal Title
  
  Cancers (Basel).
  
  Volume: 15(3) Issue: 3 Pages: 606-606
- DOI
  10.3390/cancers15030606
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07410, KAKENHI-PROJECT-23K06427
[Journal Article] CD70 and PD-L1 (CD274) co-expression predicts poor clinical outcomes in patients with pleural mesothelioma.2023
- Author(s)
  Inaguma S, Ueki A, Lasota J, Komura M, Sheema AN, Czapiewski P, Langfort R, Rys J, Szpor J, Waloszczyk P, Okon; K, Biernat W, Schrump DS, Hassan R, Miettinen M, Takahashi S.
- Journal Title
  
  J Pathol Clin Res.
  
  Volume: 9(3) Issue: 3 Pages: 195-207
- DOI
  10.1002/cjp2.310
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07410, KAKENHI-PROJECT-23K06427
[Journal Article] PBK Enhances Cellular Proliferation With Histone H3 Phosphorylation and Suppresses Migration and Invasion With CDH1 Stabilization in Colorectal Cancer2022
- Author(s)
  Koshino Akira、Nagano Aya、Ota Akinobu、Hyodo Toshinori、Ueki Akane、Komura Masayuki、Sugimura-Nagata Akane、Ebi Masahide、Ogasawara Naotaka、Kasai Kenji、Hosokawa Yoshitaka、Kasugai Kunio、Takahashi Satoru、Inaguma Shingo
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: 12 Pages: 772926-772935
- DOI
  10.3389/fphar.2021.772926
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14703, KAKENHI-PROJECT-19K07486, KAKENHI-PROJECT-20K07410, KAKENHI-PROJECT-21K08426, KAKENHI-PROJECT-19K08668
[Journal Article] SPATA18 expression predicts favorable clinical outcome in colorectal cancer.2022
- Author(s)
  Sugimura-Nagata, A., Koshino, A., Nagao, K., Nagano, A., Komura, M., Ueki, A., Ebi, M., Ogasawara, N., Tsuzuki, T., Kasai, K., Takahashi, S., Kasugai, K., Inaguma, S.
- Journal Title
  
  International Journal of Molecular Science
  
  Volume: 23 Issue: 5 Pages: 2753-2753
- DOI
  10.3390/ijms23052753
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07486, KAKENHI-PROJECT-20K07410
[Journal Article] The complete loss of p53 expression uniquely predicts worse prognosis in colorectal cancer.2022
- Author(s)
  Nagao, K., Koshino, A., Sugimura-Nagata, A., Nagano, A., Komura, M., Ueki, A., Ebi, M., Ogasawara, N., Tsuzuki, T., Kasai, K., Takahashi, S., Kasugai, K., Inaguma, S.
- Journal Title
  
  International Journal of Molecular Science
  
  Volume: 23 Issue: 6 Pages: 3252-3252
- DOI
  10.3390/ijms23063252
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07486, KAKENHI-PROJECT-20K07410
[Journal Article] PBK expression predicts favorable survival in colorectal cancer patients2021
- Author(s)
  Nagano-Matsuo A, Inoue S, Koshino A, Ota A, Nakao K, Komura M, Kato H, Naiki-Ito A, Watanabe K, Nagayasu Y, Hosokawa Y, Takiguchi S, Kasugai K, Kasai K, Inaguma S, Takahashi S
- Journal Title
  
  Virchows Archiv
  
  Volume: - Issue: 2 Pages: 277-284
- DOI
  10.1007/s00428-021-03062-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07486, KAKENHI-PROJECT-20K07410, KAKENHI-PROJECT-20K16225, KAKENHI-PROJECT-17K08706, KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-21K08426
[Journal Article] Expression and Prognostic Significance of CD47-SIRPA Macrophage Checkpoint Molecules in Colorectal Cancer2021
- Author(s)
  Sugimura-Nagata A, Koshino A, Inoue S, Matsuo-Nagano A, Komura M, Riku M, Ito H, Inoko A, Murakami H, Ebi M, Ogasawara N, Tsuzuki T, Takahashi S, Kasugai K, Kasai K, Inaguma S
- Journal Title
  
  International Journal of Molecular Science
  
  Volume: 22 Issue: 5 Pages: 2690-2690
- DOI
  10.3390/ijms22052690
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07486, KAKENHI-PROJECT-20K07410, KAKENHI-PROJECT-20K16182, KAKENHI-PROJECT-17K08706
[Journal Article] Colorectal Adenocarcinomas Harboring ALK Fusion Genes: A Clinicopathologic and Molecular Genetic Study of 12 Cases and Review of the Literature.2021
- Author(s)
  Lasota J, Inaguma S, Izycka-Swieszewska E, Kaczorowski M, Kolos M, Kopczynski J, Michal M, Milione M, Okon K, Peksa R, Pyzlak M, Rys J, Waloszczyk P, Wejman J, Miettinen M.
- Journal Title
  
  Am J Surg Pathol.
  
  Volume: 44(9) Issue: 9 Pages: 1224-1234
- DOI
  10.1097/pas.0000000000001512
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07410, KAKENHI-PROJECT-17K08706
[Journal Article] High phospho-histone H3 expression uniquely predicts favorable survival among four markers of cellular proliferation in colorectal cancer.2021
- Author(s)
  Koshino A, Inoue S, Sugimura-Nagata A, Nishiyama T, Murakami H, Ito H, Riku M, Inoko A, Ebi M, Ogasawara N, Tsuzuki T, Kasugai K, Kasai K, Inaguma S.
- Journal Title
  
  Pathol Int.
  
  Volume: - Issue: 5 Pages: 2690-2690
- DOI
  10.1111/pin.13084
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07410, KAKENHI-PROJECT-20K16182, KAKENHI-PROJECT-17K08706
[Journal Article] Colonic Adenocarcinomas Harboring NTRK Fusion Genes: A Clinicopathologic and Molecular Genetic Study of 16 Cases and Review of the Literature.2020
- Author(s)
  Lasota J, Chlopek M, Lamoureux J, Christiansen J, Kowalik A, Wasag B, Felisiak-Golabek A, Agaimy A, Biernat W, Canzonieri V, Centonze G, Chmielik E, Daum O, Dubova M, Dziuba I, Goertz S, Gozdz S, Guttmejer-Nasierowska A, Haglund C, Halon A, Hartmann A, Inaguma S, Miettinen M et. al.
- Journal Title
  
  Am J Surg Pathol.
  
  Volume: 44(2) Issue: 2 Pages: 162-173
- DOI
  10.1097/pas.0000000000001377
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08706
[Journal Article] Diffuse mesothelin expression leads to worse prognosis through enhanced cellular proliferation in colorectal cancer.2020
- Author(s)
  Inoue S, Tsunoda T, Riku M, Ito H, Inoko A, Murakami H, Ebi M, Ogasawara N, Pastan I, Kasugai K, Kasai K, Ikeda H, Inaguma S.
- Journal Title
  
  Oncol Lett.
  
  Volume: 19(3) Pages: 1741-1750
- DOI
  10.3892/ol.2020.11290
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08706, KAKENHI-PROJECT-20K16182
[Journal Article] CD70 expression correlates with a worse prognosis in malignant pleural mesothelioma patients via immune evasion and enhanced invasiveness.2020
- Author(s)
  Inaguma S, Lasota J, Czapiewski P, Langfort R, Rys J, Szpor J, Waloszczyk P, Okon; K, Biernat W, Schrump DS, Hassan R, Kasai K, Miettinen M, Ikeda H.
- Journal Title
  
  J Pathol.
  
  Volume: 250(2) Issue: 2 Pages: 205-216
- DOI
  10.1002/path.5361
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08706
[Journal Article] CD70 expression in tumor-associated fibroblasts predicts worse survival in colorectal cancer patients2019
- Author(s)
  Inoue Satoshi、Ito Hideaki、Tsunoda Takumi、Murakami Hideki、Ebi Masahide、Ogasawara Naotaka、Kasugai Kunio、Kasai Kenji、Ikeda Hiroshi、Inaguma Shingo
- Journal Title
  
  Virchows Archiv
  
  Volume: 000 Issue: 4 Pages: 000-000
- DOI
  10.1007/s00428-019-02565-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08706
[Journal Article] Histopathological and genotypic characterization of metastatic colorectal carcinoma with PD-L1 (CD274)-expression: Possible roles of tumour micro environmental factors for CD274 expression.2017
- Author(s)
  Inaguma S., Lasota J., Felisiak-Golabek A., Kowalik A., Wang Z., Zieba S., Kalisz J., Ikeda H., Miettinen M.
- Journal Title
  
  J Pathol Clin Res.
  
  Volume: 3(4) Issue: 4 Pages: 268-278
- DOI
  10.1002/cjp2.81
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08706
[Journal Article] GLI1 orchestrates CXCR4/CXCR7 signaling to enhance migration and metastasis of breast cancer cells2015
- Author(s)
  Shingo Inaguma, Miho Riku, Hideaki Ito, Takumi Tsunoda, Hiroshi Ikeda, Kenji Kasai
- Journal Title
  
  Oncotarget
  
  Volume: Vol6, No32 Issue: 32 Pages: 33648-33657
- DOI
  10.18632/oncotarget.5203
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08358
[Journal Article] Down-regulation of the zinc-finger homeobox protein TSHZ2 releases GLI1 from the nuclear repressor complex to restore its transcriptional activity during mammary tumorigenesis2015
- Author(s)
  Miho Riku, Shingo Inaguma, Hideaki Ito, Takumi Tsunoda, Hiroshi Ikeda, Kenji Kasai
- Journal Title
  
  Oncotarget
  
  Volume: vol7, No5 Issue: 5 Pages: 5690-5701
- DOI
  10.18632/oncotarget.6788
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08358
[Journal Article] GLI1 interferes with the DNA mismatch repair system in pancreatic cancer through BHLHE41-mediated suppression of MLH1.2013
- Author(s)
  Shingo Inaguma, Miho Riku, Mitsuyoshi Hashimoto, Hideki Murakami, Shinsuke Saga, Hiroshi Ikeda and Kenji Kasai.
- Journal Title
  
  Cancer Research
  
  Volume: 73 Pages: 7313-7323
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590456
[Journal Article] GLI1 modulates EMT in pancreatic cancer-Letter2012
- Author(s)
  Shingo Inaguma, Kenji Kasai, Mitsuyoshi Hashimoto, Hiroshi Ikeda
- Journal Title
  
  Cancer Research
  
  Volume: (in press) Issue: 14 Pages: 3702-3
- DOI
  10.1158/0008-5472.can-12-0379
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590408, KAKENHI-PROJECT-23790424, KAKENHI-PROJECT-24590456
[Journal Article] GLI1 facilitates the migration and invasion of pancreatic cancer cells through MUC5AC-mediated attenuation of E-cadherin.2011
- Author(s)
  Inaguma S., et al.
- Journal Title
  
  Oncogene
  
  Volume: 30巻 Pages: 714-723
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790370
[Journal Article] GLI1 facilitates the migration and invasion of pancreatic cancer cells through MUC5AC-mediated attenuation of E-cadherin2011
- Author(s)
  Shingo Inaguma, Kenji Kasai, Hiroshi Ikeda
- Journal Title
  
  Oncogene 30(6)
  
  Pages: 714-723
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790370
[Journal Article] GLI1 facilitates the migration and invasion of pancreatic cancer cells through MUC5AC-mediated attenuation of E-cadherin2011
- Author(s)
  Shingo Inaguma, Kenji Kasai, Hiroshi Ikeda
- Journal Title
  
  Oncogene
  
  Volume: 30 Issue: 6 Pages: 714-723
- DOI
  10.1038/onc.2010.459
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590408
[Journal Article] GLI1 facilitates the migarion and invasion of pancreatic cancer cellls through MUC5AC-mediated attenuation of E-cadherin.2011
- Author(s)
  S Inaguma, K Kasai, H Ikeda.
- Journal Title
  
  Oncogene
  
  Volume: 30巻 Pages: 714-723
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590408
[Journal Article] SCL/TAL1 Interrupting Locus derepresses GLI1 from the negative control of Suppressor-of-Fused in pancreatic cancer cell2008
- Author(s)
  Kenji Kasai, Shingo Inaguma, Akiko Yoneyama, Kazuhiro Yoshikawa, Hiroshi Ikeda
- Journal Title
  
  Cancer Research 66
  
  Pages: 7723-7729
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590371
[Presentation] CD70およびPD-L1は協調的に腫瘍浸潤・免疫逃避を促進し悪性胸膜中皮腫の予後を予測する2024
- Author(s)
  稲熊真悟、Chengbo Wang、小村理行、加藤寛之、内木　綾、髙橋　智
- Organizer
  日本病理学会
- Data Source
  KAKENHI-PROJECT-23K06446
[Presentation] 腫瘍細胞および間質組織に発現するテトラスパニンは乳癌の予後を予測する2024
- Author(s)
  小村理行、加藤寛之、内木綾、稲熊真悟、高橋智
- Organizer
  第113回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-23K06427
[Presentation] CD70およびPD-L1は協調的に腫瘍浸潤・免疫逃避を促進し悪性胸膜中皮腫患者の予後を悪化させる2024
- Author(s)
  稲熊真悟、上木あかね、Chengbo Wang、小村理行、加藤寛之、内木　綾、高橋　智
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-23K06446
[Presentation] 腫瘍細胞および間質組織に発現するテトラスパニンは乳癌の予後を予測する2023
- Author(s)
  小村理行、加藤寛之、内木綾、稲熊真悟、高橋智
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K06427
[Presentation] PD-L1陽性大腸癌細胞は幹細胞様表現型を示し、特徴的な遺伝子発現、高悪性形質を示す2022
- Author(s)
  稲熊真悟、上木あかね、小村理行、加藤寛之、内木綾、高橋智
- Organizer
  日本病理学会
- Data Source
  KAKENHI-PROJECT-20K07410
[Presentation] PBKは大腸癌細胞の増殖を促進させる一方で、Eカドヘリンを安定化させ、浸潤・遊走を抑制する2022
- Author(s)
  稲熊真悟、長野愛矢、上木あかね、小村理行、加藤寛之、内木綾、高橋智
- Organizer
  日本病理学会
- Data Source
  KAKENHI-PROJECT-20K07410
[Presentation] PD-L1-positive colorectal cancer cells harbor higher malignant potentials with “stem-like” immunophenotype and specific gene expressions.2022
- Author(s)
  Shingo Inaguma, Akane Ueki, Masayuki Komura, Hiroyuki Kato, Aya Naiki-Ito, Satoru Takahashi.
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-20K07410
[Presentation] PBKは大腸癌細胞の増殖を促進させる一方で、Eカドヘリンを安定化させ、浸潤・遊走を抑制する2021
- Author(s)
  稲熊真悟、長野愛矢、小村理行、加藤寛之、内木綾、高橋智
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-20K07410
[Presentation] 大腸癌細胞におけるPBK発現は大腸癌患者の予後良好因子である2021
- Author(s)
  長野愛矢、中尾健寿、内木綾、笠井謙次、稲熊真悟、高橋智
- Organizer
  日本病理学会
- Data Source
  KAKENHI-PROJECT-20K07410
[Presentation] CD70分子はMET-ERK経路の活性化、腫瘍細胞の免疫逃避亢進により悪性胸膜中皮腫患者の予後を悪化させる2020
- Author(s)
  稲熊真悟、Jerzy Lasota, 池田　洋、笠井謙次、Markku Miettinen、高橋　智
- Organizer
  日本病理学会
- Data Source
  KAKENHI-PROJECT-17K08706
[Presentation] CD70 upregulates migration and invasion of malignant pleural mesothelioma cells through ERK pathway.2019
- Author(s)
  Inaguma S., Lasota J., Tsunoda T., Ito H., Murakami H., Kasai K., Miettinen M., Ikeda H.
- Organizer
  日本病理学会
- Data Source
  KAKENHI-PROJECT-17K08706
[Presentation] CD70 expression in tumor-associated fibroblasts predicts worse survival in colorectal cancer patients.2019
- Author(s)
  Inoue S., Ito H., Tsunoda T., Murakami H., Ebi M., Ogasawara N., Kasugai K., Kasai K., Ikeda H., Inaguma S.
- Organizer
  日本病理学会
- Data Source
  KAKENHI-PROJECT-17K08706
[Presentation] ヘッジホッグ系転写因子GLI1はCXCL12/CXCR4経路の活性化により乳癌細胞の遊走能を亢進させる2015
- Author(s)
  稲熊真悟、笠井謙次、伊藤秀明、陸美穂、池田洋
- Organizer
  第104回日本病理学会総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-04-30
- Data Source
  KAKENHI-PROJECT-15K08358
[Presentation] 新規転写抑制因子TSHZ2からみた乳癌進展機構2015
- Author(s)
  陸美穂、笠井謙次、稲熊真悟、伊藤秀明、池田洋
- Organizer
  第104回日本病理学会総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-04-30
- Data Source
  KAKENHI-PROJECT-15K08358
[Presentation] ZIC2 is an indispensable transcription factor for the cell growth of pancreatic ductal adenocarcinoma.2014
- Author(s)
  Shingo Inaguma, Kenji Kasai, Mitsuyoshi Hashimoto, Miho Riku, Hiroshi Ikeda.
- Organizer
  USCAP 2014, annual meeting.
- Place of Presentation
  San Diego, CA.
- Data Source
  KAKENHI-PROJECT-23790424
[Presentation] ヘッジホッグシグナル系転写因子ZIC2はFGFR3, ANXA8L2発現誘導を介して膵発がんを促進する2014
- Author(s)
  稲熊真悟, ら
- Organizer
  第103回日本病理学会総会
- Place of Presentation
  広島
- Year and Date
  2014-04-25
- Data Source
  KAKENHI-PROJECT-23790424
[Presentation] ヘッジホッグシグナル系転写因子ZIC2はFGFR3, ANXA8L2発現誘導を介して膵発癌を促進する2014
- Author(s)
  稲熊真悟、笠井謙次、橋本光義、陸美穂、池田洋
- Organizer
  第103回　日本病理学会総会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23790424
[Presentation] ZIC2 is an indispensable transcription factor for the cell growth of pancreatic ductal adenocarcinoma2014
- Author(s)
  Shingo INAGUMA, et.al
- Organizer
  USCAP 2014 annual meeting
- Place of Presentation
  San Diego
- Year and Date
  2014-03-04
- Data Source
  KAKENHI-PROJECT-23790424
[Presentation] ヘッジホッグシグナル系転写因子ZIC2はFGFR3、ANXA8L2発現誘導を介して膵発がんを促進する2014
- Author(s)
  稲熊真悟、笠井謙次、橋本光義、陸美穂、池田洋
- Organizer
  第103回日本病理学会総会
- Place of Presentation
  広島国際会議場
- Data Source
  KAKENHI-PROJECT-24590456
[Presentation] ZIC2 is an indispensable transcriptional factor for the cell gwoth of pancreatic duct adenocarcinoma.2014
- Author(s)
  S Inaguma, K Kasai, M Hashimoto, M Riku, H Ikeda
- Organizer
  103rd Annuak Meeting of USCAP
- Place of Presentation
  San Diego, CA, USA
- Data Source
  KAKENHI-PROJECT-24590456
[Presentation] Hedgehogシグナル系転写活性化因子GLI1から見た膵臓前がん病変の細胞生物学的特性2013
- Author(s)
  稲熊真悟、笠井謙次。橋本光義、陸美穂、池田洋
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  ロイトン札幌
- Data Source
  KAKENHI-PROJECT-24590456
[Presentation] 膵臓癌細胞において転写因子GLI1はBHLHE41依存性にMLH1発現を抑制し、ミスマッチ修復機構の機能不全を惹起する2013
- Author(s)
  稲熊真悟、笠井謙次、橋本光義、陸美穂、池田洋
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24590456
[Presentation] 胃小細胞癌の一例:遺伝子変異LOH解析を含めた検討2011
- Author(s)
  稲熊真悟、笠井謙次、池田洋
- Organizer
  第100回日本病理学会総会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2011-04-29
- Data Source
  KAKENHI-PROJECT-21590408
[Presentation] 胃小細胞癌の一例遺伝子変異・LOH解析を含めた検討2011
- Author(s)
  稲熊真悟、笠井謙次、池田洋
- Organizer
  第100回日本病理学会総会
- Place of Presentation
  パシフィコ横浜(横浜市)(一般示説)
- Year and Date
  2011-04-29
- Data Source
  KAKENHI-PROJECT-21590408
[Presentation] GLI1 induces the expression of bHLH type of transcriptional repressor DEC2 in pancreatic cancer cells2010
- Author(s)
  Shingo Inaguma, Kenji Kasai, Hiroshi Ikeda
- Organizer
  101st Annual meeting of American Association for Cancer Research
- Place of Presentation
  Washington, DC
- Year and Date
  2010-04-20
- Data Source
  KAKENHI-PROJECT-21790370
[Presentation] GLI1はMUC5ACの発現誘導によってE-cadherinによる細胞間接着を阻害し膵癌細胞の遊走・浸潤を促進する2010
- Author(s)
  稲熊真悟、笠井謙次、池田洋
- Organizer
  第99回日本病理学会総会
- Place of Presentation
  新宿区
- Year and Date
  2010-04-29
- Data Source
  KAKENHI-PROJECT-21790370
[Presentation] GLI1 induces the expression of bHLH type of transcriptional repressor DEC2 in pancreatic cancer cells.2010
- Author(s)
  Inaguma S., et al.
- Organizer
  American Association for Cancer Research
- Place of Presentation
  Walter E.Washington Convention Center (Washington, DC)
- Year and Date
  2010-04-20
- Data Source
  KAKENHI-PROJECT-21790370
[Presentation] GLI1はMUC5ACの発現誘導によってE-cadherinによる細胞間接着を阻害し膵癌細胞の遊走・浸潤を促進する2010
- Author(s)
  稲熊真悟、笠井謙次、米山亜紀子、池田洋
- Organizer
  第99回日本病理学会総会
- Place of Presentation
  京王プラザホテル(東京都)
- Year and Date
  2010-04-29
- Data Source
  KAKENHI-PROJECT-21590408
[Presentation] GLI1はgel forming mucin MUC5ACの発現上昇によって膵癌細胞の浸潤・遊走能を亢進させる2009
- Author(s)
  稲熊真悟、笠井謙次、池田洋
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜市
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21790370
[Presentation] 膵癌細胞においてGLI1はbHLH型転写抑制因子DEC2の発現を直接誘導しMLH1を介した遺伝子不安定制に寄与する2009
- Author(s)
  稲熊真悟、笠井謙次、米山亜紀子、池田洋
- Organizer
  第98回日本病理学会総会
- Place of Presentation
  京都市
- Year and Date
  2009-05-03
- Data Source
  KAKENHI-PROJECT-21790370
[Presentation] 膵臓癌においてGLI1はbHLH型転写抑制因子DEC2の発現を直接誘導しMLH1を介した遺伝子不安定性に寄与する2009
- Author(s)
  稲熊真悟、笠井謙次、米山亜紀子、池田洋
- Organizer
  第98回日本病理学会総会
- Place of Presentation
  国立京都国際会館(京都市)
- Year and Date
  2009-05-03
- Data Source
  KAKENHI-PROJECT-21590408
[Presentation] GLI1 enhances the motility and invasion by gel forming mucin MUC5AC up-regulation in pancreatic cancer cells2009
- Author(s)
  稲熊真悟
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  パシフイコ横浜(横浜市)
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21590408
[Presentation] 膵臓癌およびPancreatic Intraepithelial Neoplasia(PanIN)におけるSIL発現状況の免疫組織学的解析2009
- Author(s)
  米山亜紀子、稲熊真悟、笠井謙次、池田洋
- Organizer
  第98回日本病理学会総会
- Place of Presentation
  国立京都国際会館(京都市)
- Year and Date
  2009-05-03
- Data Source
  KAKENHI-PROJECT-21590408
[Presentation] 膵癌細胞においてGLI1はbHLH型転写抑制因子DEC2の発現を直接誘導しMLH1を介した遺伝子不安定性に寄与する2009
- Author(s)
  稲熊真悟
- Organizer
  第98回日本病理学会総会
- Place of Presentation
  国立京都国際会館(京都市)
- Year and Date
  2009-05-03
- Data Source
  KAKENHI-PROJECT-21590408
[Presentation] 膵臓癌およびPancreatic Intraepithelial Neoplasia(PanIN)におけるSIL発現状況の免疫組織学的検討2009
- Author(s)
  米山亜紀子、笠井謙次、稲熊真悟、池田洋
- Organizer
  第98回日本病理学会総会
- Place of Presentation
  京都市
- Year and Date
  2009-05-03
- Data Source
  KAKENHI-PROJECT-21790370
[Presentation] GLI1 enhances themotility and invasion by gel forming mucin MUC5AC up-regulation in pancreatic cancer cells2009
- Author(s)
  稲熊真悟、笠井謙次
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21590408
[Presentation] がん細胞において転写因子GLI1はbHLH型転写抑制因子DEC2、HES1の発現を直接誘導する2008
- Author(s)
  稲熊真悟、笠井謙次、池田洋
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋市
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-19590371
[Presentation] 膵臓癌におけるHedgehogシグナル系転写因子GLI1のSUFU依存性制御からの離脱機構2008
- Author(s)
  笠井謙次、稲熊真悟、米山亜紀子、池田洋
- Organizer
  第97回日本病理学会総会
- Place of Presentation
  金沢市
- Year and Date
  2008-05-17
- Data Source
  KAKENHI-PROJECT-19590371
[Presentation] SILによるGLI1のSUFU依存性制御からの離脱機構2008
- Author(s)
  笠井謙次、稲熊真悟、池田洋
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋市
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-19590371
[Presentation] 膵前癌病変におけるShh-GLT1標的遺伝子MUC5ACの発現解析2008
- Author(s)
  稲熊真悟
- Organizer
  第97回日本病理学会総会
- Place of Presentation
  金沢市
- Year and Date
  2008-05-17
- Data Source
  KAKENHI-PROJECT-19590371
[Presentation] 膵前癌病変におけるShh-GLI1標的遺伝子MUC5ACの発現解析2008
- Author(s)
  稲熊真悟、笠井謙次、米山亜紀子、池田洋
- Organizer
  第97回日本病理学会総会
- Place of Presentation
  金沢市
- Year and Date
  2008-05-17
- Data Source
  KAKENHI-PROJECT-19590371
[Presentation] ヘッジホッグ系転写因子GLI1はCXCL12/CXCR4経路の活性化により乳癌細胞の遊走能を亢進させる
- Author(s)
  稲熊真悟、笠井謙次、伊藤秀明、陸美穂、池田洋
- Organizer
  第104回日本病理学会総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-04-30 – 2015-05-02
- Data Source
  KAKENHI-PROJECT-24590456

1. IKEDA Hiroshi (00131219)

# of Collaborated Projects: 5 results

# of Collaborated Products: 23 results
2. KASAI Kenji (70242857)

# of Collaborated Projects: 4 results

# of Collaborated Products: 24 results
3. ITO Hideaki (90711276)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
4. 太田明伸 (30438048)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. NAKAO HARUHISA (60326139)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 小村理行 (60377934)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. 高橋智 (60254281)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
8. 内木綾 (20509236)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. 加藤寛之 (80791293)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
10. 兵頭寿典 (40710645)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 大谷隆浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Inaguma Shingo 稲熊 真悟

INAGUMA Shingo 稲熊 真悟

Research Projects

Research Products

Co-Researchers

CD81発現乳癌のエクソソーム制御を介した悪性形質・癌微小免疫環境調節機構の解析

Principal Investigator

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PBKリン酸化標的遺伝子を介した大腸癌悪性形質制御機構の解析と治療応用の可能性Principal Investigator

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Regulation of the tumor malignant potentials and immune evasion by CD70-positive stromal cells.Principal Investigator

Principal Investigator

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Review Section

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Malignant potential of PD-L1-positive pancreatic cancer cells. Analysis of the stemness and epithelial to mesenchymal transition.Principal Investigator

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The analysis of the p53 isoforms in hepatocellular carcinoma cells using endogenous gene modification.

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Downstream of newly identified transcriptional repressor and its role in the progression of non-invasive breast cancer.

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Roles of the newly identified GLI1-CXCR4 signaling in synovial sarcoma cells.Principal Investigator

Principal Investigator

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Hedgehog signaling molecule SIL regulates the migration and progression of pancreatic ductal adenocarcinoma.

Principal Investigator

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Analysis of the cell growth mechanism by ZIC2 transcription factor in pancreatic cancer cells.Principal Investigator

Principal Investigator

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Roles of SIX3 and SIL in the Hedgehog signaling during pancreatic carcinogenesis.

Principal Investigator

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Roles of HES1 and DEC2, newly identified transcriptional targets of GLI1, in pancreatic carcinogenesis.Principal Investigator

Principal Investigator

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Roles of the Hedgehog signaling in invasion and metastasis of pancreatic cancer

Principal Investigator

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膵癌における分子標的治療を目指した神経分化成長因子Shh発現機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Inaguma Shingo 稲熊真悟

INAGUMA Shingo 稲熊真悟