Ishii Takehiko 石井武彦

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ISHII Takehiko 石井武彦

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Researcher Number	80415075
Other IDs
Affiliation (based on the past Project Information) *help	2017: 東京大学, 大学院工学系研究科, 特任准教授 2014: 東京大学, 大学院工学系研究科, 特任准教授 2013 – 2014: 東京大学, 工学(系)研究科(研究院), 准教授 2012: 東京大学, 大学院・工学系研究科, 特任准教授 2009 – 2010: 東京大学, 大学院・工学系研究科, 特任助教 2008 – 2010: The University of Tokyo, 大学院・工学系研究科, 助教
Review Section/Research Field	Principal Investigator Polymer chemistry / Biomedical engineering/Biological material science Except Principal Investigator Biomedical engineering/Biological material science / Chemistry / Science and Engineering / Biological Sciences
Keywords	Principal Investigator 細胞内ATP / 細胞内ＡＴＰ / フェニルボロン酸 / 核酸デリバリー / 環境応答性高分子ミセル / DDS / ポリイオンコンブレックス / 遺伝子治療 / 静電相互作用 / 疎水性相互作用 … More / ポリイオンコンプレックス / 遺伝子ベクター / PEG / 非ウィルス型遺伝子ベクター / 薬物送達システム … More Except Principal Investigator siRNA / 高分子ミセル / がん治療 / 遺伝子治療 / ドラッグデリバリー / グルコーストランスポ-ター / 脳―血液関門 / 脳一血液関門 / グルコーストランスポーター / アルツハイマー病 / 脳-血液関門 / 抗体医薬 / プラスミドDNA / メッセンジャーRNA / アンチセンス核酸 / 血液脳関門（BBB） / 薬物送達システム / ポリアミノ酸 / ポリエチレングリコール / ブロック共重合体 / 中枢神経系 / 免疫原性 / 神経障害 / ナノミセル / DDS / mRNA / 機能ポ性リマー / 機能性ポリマー / がん標的治療 / 化学療法 / ナノテクノロジー / がん化学療法 / ナノキャリア Less

フェニルボロン酸を安定化要素とするリボ核酸送達用高分子ミセルの研究開発Principal Investigator
- Principal Investigator
  
  石井武彦
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Polymer chemistry
- Research Institution
  The University of Tokyo
Development of Polymeric Micelles for Brain-Targeted Delivery of Nucleic Acid Drugs to Treat Intractable Neurological Diseases
- Principal Investigator
  
  KATAOKA Kazunori
- Project Period (FY)
  2013 – 2017
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Science and Engineering
  Chemistry
- Research Institution
  Kawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine
  The University of Tokyo
Development of in vivo mRNA delivery system for treating diseases
- Principal Investigator
  
  ITAKA Keiji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  The University of Tokyo
Development of multifunctional polymeric micelles for systemic siRNA delivery
- Principal Investigator
  
  KATAOKA Kazunori
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  The University of Tokyo
Preparation of stable supramolecular gene vector in blood and improvement of gene expression efficiencyPrincipal Investigator
- Principal Investigator
  
  ISHII Takehiko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  The University of Tokyo
Polymeric micelle nanocarrier for drug and gene delivery
- Principal Investigator
  
  KATAOKA Kazunori
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo

All 2018 2017 2016 2015 2014 2013 2011 2010 2009 2008 Other

All Journal Article Presentation Patent

[Journal Article] Enhanced intracellular delivery of siRNA by controlling ATP-responsivity of phenylboronic acid-functionalized polyion complex micelles.2018
- Author(s)
  M. Naito, N. Yoshinaga, T. Ishii, A. Matsumoto, Y. Miyahara, K. Miyata, K. Kataoka
- Journal Title
  
  Macromol. Biosci.
  
  Volume: 1 Issue: 1
- DOI
  10.1002/mabi.201700357
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25000006
[Journal Article] Polyplex Micelles with Phenylboronate/Gluconamide Cross-Linking in the Core Exerting Promoted Gene Transfection through Spatiotemporal Responsivity to Intracellular pH and ATP Concentration2017
- Author(s)
  Yoshinaga Naoto、Ishii Takehiko、Naito Mitsuru、Endo Taisuke、Uchida Satoshi、Cabral Horacio、Osada Kensuke、Kataoka Kazunori
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 139 Issue: 51 Pages: 18567-18575
- DOI
  10.1021/jacs.7b08816
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K20086, KAKENHI-PROJECT-16H03178, KAKENHI-PROJECT-16H03179, KAKENHI-PROJECT-15K20962, KAKENHI-PROJECT-25000006
[Journal Article] Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain2017
- Author(s)
  Anraku Y.、Kuwahara H.、Fukusato Y.、Mizoguchi A.、Ishii T.、Nitta K.、Matsumoto Y.、Toh K.、Miyata K.、Uchida S.、Nishina K.、Osada K.、Itaka K.、Nishiyama N.、Mizusawa H.、Yamasoba T.、Yokota T.、Kataoka K.
- Journal Title
  
  Nat Commun
  
  Volume: 8 Issue: 1 Pages: 2001-2009
- DOI
  10.1038/s41467-017-00952-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17KT0048, KAKENHI-PROJECT-16K11226, KAKENHI-PROJECT-17K20086, KAKENHI-PROJECT-15H04635, KAKENHI-PROJECT-15H04813, KAKENHI-PROJECT-16H03178, KAKENHI-PROJECT-17H04742, KAKENHI-PROJECT-16F16058, KAKENHI-PROJECT-16F16407, KAKENHI-PROJECT-16K15104, KAKENHI-PROJECT-15K20962, KAKENHI-PROJECT-25000006
[Journal Article] Multilayered polyion complexes with dissolvable silica layer covered by controlling densities of cRGD-conjugated PEG chains for cancer-targeted siRNA delivery.2017
- Author(s)
  M. Naito, R. Azuma, H. Takemoto, M. Hori, N. Yoshinaga, S. Osawa, R. Kamegawa, H. -J. Kim, T. Ishii, N. Nishiyama, K. Miyata, K. Kataoka
- Journal Title
  
  J. Biomater. Sci. Polym.
  
  Volume: 28 Issue: 10-12 Pages: 1109-1123
- DOI
  10.1080/09205063.2017.1301775
- Description
  【掲載確定】 in press
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25000006, KAKENHI-PROJECT-15H04635, KAKENHI-PROJECT-16F16058, KAKENHI-PROJECT-16F16407, KAKENHI-PROJECT-16K15104, KAKENHI-PROJECT-25282141
[Journal Article] A facile amino-functionalization of poly (2-oxazoline) s' distal end through sequential azido end-capping and Staudinger reactions.2017
- Author(s)
  S. Osawa, T. Ishii, H. Takemoto, K. Osada, K. Kataoka
- Journal Title
  
  Eur. Polym. J.
  
  Volume: 88 Pages: 553-561
- DOI
  10.1016/j.eurpolymj.2016.11.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25000006, KAKENHI-PROJECT-16H03178
[Journal Article] Synthetic polyamines to regulate mRNA translation through the preservative binding of eukaryotic initiation factor 4E to the cap structure.2016
- Author(s)
  H. Uchida, K. Itaka, S. Uchida, T. Ishii, T. Suma, K. Miyata, M. Oba, N. Nishiyama, K. Kataoka
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 138 Issue: 5 Pages: 1478-1481
- DOI
  10.1021/jacs.5b11726
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K20962, KAKENHI-PROJECT-15H03017, KAKENHI-PROJECT-25000006
[Journal Article] Polyplex micelles with double-protective compartments of hydrophilic shell and thermo-switchable palisade of poly (oxazoline)-based block copolymers for promoted gene transfection.2016
- Author(s)
  S. Osawa, K. Osada, S. Hiki, A. Dirisala, T. Ishii, K. Kataoka
- Journal Title
  
  Biomacromolecules
  
  Volume: 17 Issue: 1 Pages: 354-361
- DOI
  10.1021/acs.biomac.5b01456
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25000006
[Journal Article] Systemic delivery of messenger RNA for the treatment of pancreatic cancer using polyplex nanomicelles with a cholesterol moiety.2016
- Author(s)
  S. Uchida, H. Kinoh, T. Ishii, A. Matsui, T. A. Tockary, K. M. Takeda, H. Uchida, K. Osada, K. Itaka, K. Kataoka
- Journal Title
  
  Biomaterials
  
  Volume: 82 Pages: 221-228
- DOI
  10.1016/j.biomaterials.2015.12.031
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K20962, KAKENHI-PROJECT-15H03017, KAKENHI-PROJECT-14J11005, KAKENHI-PROJECT-25000006
[Journal Article] Enhanced target recognition of nanoparticles by cocktail PEGylation with chains of varying lengths.2016
- Author(s)
  T. Ishii, K. Miyata, Y. Anraku, M. Naito, Y. Yi, T. Jinbo, S. Takae, Y. Fukusato, M. Hori, K. Osada, K. Kataoka
- Journal Title
  
  Chem. Commun.
  
  Volume: 52 Pages: 1517-1519
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25000006
[Journal Article] Polyplex micelle installing intracellular self-processing functionalities without free catiomers for safe and efficient systemic gene therapy through tumor vasculature targeting2016
- Author(s)
  Q. Chen, K. Osada, Z. Ge, S. Uchida, T. A. Tockary, A. Dirisala, A. Matsui, K. Toh, K. M. Takeda, X. Liu, T. Nomoto, T. Ishii, M. Oba, Y. Matsumoto, K. Kataoka
- Journal Title
  
  Biomaterials
  
  Volume: 113 Pages: 253-265
- DOI
  10.1016/j.biomaterials.2016.10.042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-14J11005, KAKENHI-PROJECT-15K20962, KAKENHI-PROJECT-25000006, KAKENHI-PROJECT-17KT0048, KAKENHI-PROJECT-16K11226, KAKENHI-PROJECT-16H03178
[Journal Article] Messenger RNA-based therapeutics for the treatment of apoptosis-associated diseases.2015
- Author(s)
  A. Matsui, S. Uchida, T. Ishii, K. Itaka, K. Kataoka
- Journal Title
  
  Scientific Reports
  
  Volume: 5 Issue: 1 Pages: 15810-15810
- DOI
  10.1038/srep15810
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K20962, KAKENHI-PROJECT-15H03017, KAKENHI-PROJECT-25000006
[Journal Article] Muscle-targeted hydrodynamic gene introduction of insulin-like growth factor-1 using polyplex nanomicelle to treat peripheral nerve injury.2014
- Author(s)
  Nagata K, Itaka K, Baba M, Uchida S, Ishii T, Kataoka K.
- Journal Title
  
  J Control Release
  
  Volume: 183C Pages: 27-34
- DOI
  10.1016/j.jconrel.2014.03.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24300170, KAKENHI-PROJECT-25000006, KAKENHI-PROJECT-25882011
[Journal Article] Multifunctional polyion complex micelle featuring enhanced stability, targetability, and endosome escapability for systemic siRNA delivery to subcutaneous model of lung cancer2014
- Author(s)
  Hyun Jin Kim, Takehiko Ishii, Meng Zheng, Sumiyo Watanabe, Kazuko Toh, Yu Matsumoto, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka
- Journal Title
  
  Drug Delivery and Translational Research
  
  Volume: 4 Issue: 1 Pages: 50-60
- DOI
  10.1007/s13346-013-0175-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13F03349, KAKENHI-PROJECT-23390009, KAKENHI-PROJECT-23790043, KAKENHI-PROJECT-24659411, KAKENHI-PROJECT-24790530, KAKENHI-PROJECT-25000006, KAKENHI-PROJECT-25282141, KAKENHI-PROJECT-26670738
[Journal Article] Optimized rod length of polyplex micelles for maximizing transfection efficiency and their performance in systemic gene therapy against stroma-rich pancreatic tumors2014
- Author(s)
  Dirisala A, Osada K, Chen Q, Tockary TA, Machitani K, Osawa S, Liu X, Ishii T, Miyata K, Oba M, Uchida S, Itaka K, Kataoka K
- Journal Title
  
  Biomaterials
  
  Volume: 35(20) Issue: 20 Pages: 5359-5368
- DOI
  10.1016/j.biomaterials.2014.03.037
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-14J11005, KAKENHI-PROJECT-24300170, KAKENHI-PROJECT-25000006, KAKENHI-PROJECT-25882011
[Journal Article] Modulated protonation of side chain aminoethylene repeats in N-substituted polyaspartamides promotes mRNA transfection2014
- Author(s)
  H. Uchida, K. Itaka, T. Nomoto, T. ishii, T. Suma, M. Ikegami, K. Miyata, M. Oba, N. Nishiyama, K. Kataoka
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 136 Issue: 35 Pages: 12396-12405
- DOI
  10.1021/ja506194z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390009, KAKENHI-PROJECT-24300170, KAKENHI-PROJECT-25000006
[Journal Article] Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors2014
- Author(s)
  Z. Ge, Q. Chen, K. Osada, X. Liu, T. A. Tockary, S. Uchida, A. Dirisala, T. Ishii, T. Nomoto, K. Toh, Y. Matsumoto, M. Oba, M. R. Kano, K. Itaka, K. Kataoka
- Journal Title
  
  Biomaterials
  
  Volume: 35 Issue: 10 Pages: 3416-3426
- DOI
  10.1016/j.biomaterials.2013.12.086
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790043, KAKENHI-PROJECT-23790433, KAKENHI-PROJECT-24300170, KAKENHI-PROJECT-24790530, KAKENHI-PROJECT-25000006, KAKENHI-PROJECT-25882011, KAKENHI-PROJECT-26293119, KAKENHI-PROJECT-26670738
[Journal Article] Polyplex micelles prepared from ω-cholesteryl PEG-polycation block copolymers for systemic gene delivery.2010
- Author(s)
  Makoto Oba, T.Ishii, 他11名
- Journal Title
  
  Biomaterials 32
  
  Pages: 652-663
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20700394
[Journal Article] Biodegradable polyamino acid-based polycations as safe and effective gene carrier minimizing cumulative toxicity2010
- Author(s)
  Keiji Itaka, Takehiko Ishii, 他1名
- Journal Title
  
  Biomaterials 31(13)
  
  Pages: 3707-3714
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20700394
[Journal Article] Efficient delivery of bioactive antibodies into the cytoplasm of living cells by charge-conversional polyion complex micelles.2010
- Author(s)
  Y.Lee, T.Ishii, 他8名
- Journal Title
  
  Angew.Chem.Int.Ed. 49(14)
  
  Pages: 2552-2555
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20700394
[Journal Article] Biodegradable polyamino acid-based polycations as safe and effective gene carrier minimizing cumulative toxicity.2010
- Author(s)
  K.Itaka, T.Ishii,, H.Hasegawa, K.Kataoka
- Journal Title
  
  Biomaterials 31(13)
  
  Pages: 3707-3714
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20700394
[Journal Article] Charge-Conversion Ternary Polyplex with Endosome Disruption Moiety : A Technique for Efficient and Safe Gene Delivery.2008
- Author(s)
  Y.Lee, T.Ishii, 他8名
- Journal Title
  
  Angew.Chem.Int.Ed. 47(28)
  
  Pages: 5163-5166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20700394
[Patent] 末端にアミノ基を有するポリマーの製造方法2017
- Inventor(s)
  片岡一則、大澤重仁、長田健介、石井武彦、武元宏泰
- Industrial Property Rights Holder
  公益財団法人川崎市産業振興財団、国立大学法人東京大学
- Filing Date
  2017
- Overseas
- Data Source
  KAKENHI-PROJECT-25000006
[Patent] 末端にアミノ基を有するポリマーの製造方法2016
- Inventor(s)
  片岡一則、大澤重仁、石井武彦、長田健介、武元宏泰
- Industrial Property Rights Holder
  公益財団法人川崎市産業振興財団、国立大学法人東京大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-144178
- Filing Date
  2016-07-22
- Data Source
  KAKENHI-PROJECT-25000006
[Patent] 医薬組成物2015
- Inventor(s)
  片岡一則, 石井武彦, 内藤瑞, 吉永直人, 遠藤泰輔
- Industrial Property Rights Holder
  国立大学法人東京大学
- Industrial Property Rights Type
  特許
- Filing Date
  2015-05-08
- Data Source
  KAKENHI-PROJECT-25000006
[Patent] 薬剤送達用のキャリア、コンジュゲートおよびこれらを含んでなる組成物並びにこれらの投与方法2014
- Inventor(s)
  片岡一則、安楽泰孝、西山伸宏、宮田完二郎、石井武彦、松本有、溝口明祐、横田隆徳、桑原宏哉、仁科一隆、水澤英洋
- Industrial Property Rights Holder
  国立大学法人東京大学国立大学法人東京医科歯科大学
- Industrial Property Rights Type
  特許
- Filing Date
  2014-11-21
- Acquisition Date
  2017-02-10
- Data Source
  KAKENHI-PROJECT-25000006
[Patent] 医薬組成物2014
- Inventor(s)
  片岡一則, 石井武彦, 内藤瑞, 吉永直人, 遠藤泰輔
- Industrial Property Rights Holder
  国立大学法人東京大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-097219
- Filing Date
  2014-05-08
- Data Source
  KAKENHI-PROJECT-25000006
[Patent] ｍＲＮＡ送達用組成物2014
- Inventor(s)
  片岡一則、位高啓史、石井武彦、内田寛邦、内田智士、馬場美雪
- Industrial Property Rights Holder
  一般社団法人医療産業イノベーション機構
- Industrial Property Rights Type
  特許
- Filing Date
  2014-02-12
- Overseas
- Data Source
  KAKENHI-PROJECT-24300170
[Patent] mRNA送達用組成物2014
- Inventor(s)
  片岡一則、位高啓史、石井武彦、内田寛邦、内田智士、馬場美雪
- Industrial Property Rights Holder
  一般社団法人医療産業イノベーション機構
- Filing Date
  2014-02-12
- Overseas
- Data Source
  KAKENHI-PROJECT-25000006
[Patent] 薬剤送達用のキャリア、コンジュゲートおよびこれらを含んでなる組成物並びにこれらの投与方法2014
- Inventor(s)
  片岡一則, 安楽泰孝, 西山伸宏, 宮田完二郎, 石井武彦, 松本有, 福里優, 溝口明祐, 横田隆徳, 桑原宏哉, 仁科一隆, 水澤英洋
- Industrial Property Rights Holder
  国立大学法人東京大学、国立大学法人東京医科歯科大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-096935
- Filing Date
  2014-05-08
- Data Source
  KAKENHI-PROJECT-25000006
[Patent] 薬剤送達用のキャリア、コンジュゲートおよびこれらを含んでなる組成物並びにこれらの投与方法2013
- Inventor(s)
  片岡一則、安楽泰孝、西山伸宏、宮田完二郎、石井武彦、松本有、福里優、溝口明祐、横田隆徳、桑原宏哉、仁科一隆、水澤英洋
- Industrial Property Rights Holder
  国立大学法人東京大学、国立大学法人東京医科歯科大
- Industrial Property Rights Type
  特許
- Filing Date
  2013-11-22
- Data Source
  KAKENHI-PROJECT-25000006
[Patent] 疎水基を導入したカチオン性高分子より形成される高効率siRNAデリバリーシステム2009
- Inventor(s)
  片岡一則・宮田完二郎・西山伸宏・石井武彦・呉寿栄・Kim HyunJin
- Industrial Property Rights Holder
  東京大学
- Filing Date
  2009-02-13
- Data Source
  KAKENHI-PROJECT-20700394
[Patent] 穏和な環境下でペプチド主鎖を切断可能なポリペプチドの製造法2009
- Inventor(s)
  片岡一則・石井武彦・位高啓史
- Industrial Property Rights Holder
  東京大学
- Industrial Property Number
  2009-296191
- Filing Date
  2009-12-25
- Data Source
  KAKENHI-PROJECT-20700394
[Patent] 疎水基を導入したカチオン性高分子より形成される高効率siRNAデリバリーシステム2009
- Inventor(s)
  片岡一則・宮田完二郎・西山伸宏一石井武彦・呉寿栄・Kim Hyun Jin
- Industrial Property Rights Holder
  東京大学
- Industrial Property Number
  2009-031799
- Filing Date
  2009-02-13
- Data Source
  KAKENHI-PROJECT-20700394
[Patent] カチオン性のポリ(アミノ酸)およびその使用2009
- Inventor(s)
  西山伸宏, 片岡一則, 宮田完二郎, 石井武彦, 呉寿栄, キムヒュンジン
- Industrial Property Rights Holder
  国立大学法人東京大学
- Industrial Property Number
  2009-031799
- Filing Date
  2009-02-12
- Data Source
  KAKENHI-PROJECT-17016017
[Presentation] 高分子ナノミセルを用いた肝ターゲットmRNAデリバリー2014
- Author(s)
  松井秋倫，内田智士，石井武彦，位髙啓史，片岡一則
- Organizer
  アンチセンス・遺伝子・デリバリーシンポジウム2014
- Place of Presentation
  東京医科歯科大学M&Dタワー（東京都）
- Year and Date
  2014-09-08
- Data Source
  KAKENHI-PROJECT-24300170
[Presentation] ポリアスパルタマイド側鎖のアミノエチレン構造の繰り返し数がmessenger RNA導入機構に及ぼす影響2014
- Author(s)
  内田寛邦，位髙啓史，宮田完二郎，石井武彦，西山伸宏，片岡一則
- Organizer
  アンチセンス・遺伝子・デリバリーシンポジウム2014
- Place of Presentation
  東京医科歯科大学M&Dタワー（東京都）
- Year and Date
  2014-09-09
- Data Source
  KAKENHI-PROJECT-24300170
[Presentation] mRNA投与による生体内での細胞アポトーシスシグナル制御2014
- Author(s)
  内田智士, 松井秋倫, 石井武彦, 位髙啓史, 片岡一則
- Organizer
  第30回日本DDS学会学術集会
- Place of Presentation
  慶應義塾大学(東京都港区)
- Year and Date
  2014-07-30
- Data Source
  KAKENHI-PROJECT-25000006
[Presentation] 効率的に血液脳関門を通過する高分子ミセルの開発2014
- Author(s)
  安楽泰孝, 福里優, 溝口明祐, 石井武彦, 藤加珠子, 松本有, 桑原宏哉, 横田隆徳, 片岡一則
- Organizer
  第30回日本DDS学会学術集会
- Place of Presentation
  慶應義塾大学(東京都港区)
- Year and Date
  2014-07-31
- Data Source
  KAKENHI-PROJECT-25000006
[Presentation] 高効率に脳血液関門を通過するスマートナノマシンの開発2014
- Author(s)
  安楽泰孝, 福里優, 溝口明祐, 石井武彦, 藤加珠子, 松本有, 桑原宏哉, 横田隆徳, 片岡一則
- Organizer
  第63回高分子学会年次大会
- Place of Presentation
  名古屋国際会議場(愛知県名古屋市)
- Year and Date
  2014-05-29
- Data Source
  KAKENHI-PROJECT-25000006
[Presentation] 高分子ミセルを用いた血液脳関門を通過する革新的技術開発2014
- Author(s)
  安楽泰孝, 福里優, 溝口明宏, 石井武彦, 松本有, 籐加珠子, 桑原宏哉, 新田佳子, 横田隆徳, 片岡一則
- Organizer
  第36回日本バイオマテリアル学会
- Place of Presentation
  タワーホール船堀(東京都江戸川区)
- Year and Date
  2014-11-18
- Data Source
  KAKENHI-PROJECT-25000006
[Presentation] mRNAの生体内送達：高分子ミセル型キャリアによる肝臓ターゲットデリバリー2014
- Author(s)
  松井　秋倫，内田　智士，石井　武彦，位髙　啓史，片岡　一則
- Organizer
  GE Life Sciences Day 2014
- Place of Presentation
  パシフィコ横浜　会議センター（横浜市）
- Year and Date
  2014-08-01
- Data Source
  KAKENHI-PROJECT-24300170
[Presentation] mRNA投与による生体内での細胞アポトーシスシグナルの制御2014
- Author(s)
  内田智士，松井秋倫，石井武彦，位高啓史，片岡一則
- Organizer
  第30回日本DDS学会学術集会
- Place of Presentation
  慶應義塾大学薬学部芝共立キャンパス（東京都）
- Year and Date
  2014-07-30
- Data Source
  KAKENHI-PROJECT-24300170
[Presentation] フェニルボロン酸を高分子ミセルコアの架橋剤として用いる細胞内環境応答型核酸デリバリーシステムの創出2014
- Author(s)
  吉永直人、遠藤泰輔、内藤瑞、石井武彦、片岡一則
- Organizer
  第63回高分子年次大会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-25870184
[Presentation] 肝臓への効率的なmRNA導入を目指したナノミセルキャリアの開発2014
- Author(s)
  松井秋倫，内田智士，石井武彦，位髙啓史，片岡一則
- Organizer
  第36回日本バイオマテリアル学会大会
- Place of Presentation
  タワーホール船堀（東京都）
- Year and Date
  2014-11-17
- Data Source
  KAKENHI-PROJECT-24300170
[Presentation] Treatment of sensory nerve disorder by in vivo mRNA introduction using polyplex nanomicelle2013
- Author(s)
  K. Itaka, M. Baba, T. Ishii, K. Kataoka
- Organizer
  40th Annual Meeting & Exposition of the Controlled Release Society
- Place of Presentation
  Hawaii Convention Center (Honolulu, Hawaii, USA)
- Year and Date
  2013-07-21
- Data Source
  KAKENHI-PROJECT-25000006
[Presentation] Regulation of mRNA immunogenicity by nanomicelle encapsulation for in vivo mRNA delivery2013
- Author(s)
  S. Uchida, K. Itaka, H. Uchida, K. Hayakawa, T. Ogata, T. Ishii, S. Fukushima, K. Osada, K. Kataoka
- Organizer
  40th Annual Meeting & Exposition of the Controlled Release Society
- Place of Presentation
  Hawaii Convention Center (Honolulu, Hawaii, USA)
- Year and Date
  2013-07-21
- Data Source
  KAKENHI-PROJECT-25000006
[Presentation] 高分子ナノミセルを用いた中枢神経系への安全かつ持続的なmRNA導入2013
- Author(s)
  内田智士、位髙啓史、内田寛邦、石井武彦、福島重人、長田健介、片岡一則
- Organizer
  第13回遺伝子・デリバリー研究会シンポジウム
- Place of Presentation
  帝京天学薬学部板橋キャンパス(東京都板橋区)
- Year and Date
  2013-05-11
- Data Source
  KAKENHI-PROJECT-25000006
[Presentation] Phenylboronate functionalized intracellular-ATP-responsive siRNA carrier based on polymeric micelle system.2013
- Author(s)
  Mitsuru Naito, Takehiko Ishii, Akira Matsumoto, Kanjiro Miyata, Yuji Miyahara, Kazunori Kataoka
- Organizer
  The 12th US-Japan Symposium on Drug Delivery Systems
- Place of Presentation
  Lahaina, Maui, Hawaii
- Data Source
  KAKENHI-PROJECT-25870184
[Presentation] 細胞内ATP濃度に応答して核酸を放出する機能性高分子ミセルの調製と機能評価2013
- Author(s)
  内藤瑞、石井武彦、松元亮、宮田完二郎、宮原裕二、片岡一則
- Organizer
  第62回高分子討論会
- Place of Presentation
  金沢大学
- Data Source
  KAKENHI-PROJECT-25870184
[Presentation] 非酵素的な生分解性を示すポリアミノ酸-ポリアスパルタミド誘導体-の遺伝子デリバリーへの応用2011
- Author(s)
  石井武彦・位高啓史・片岡一則
- Organizer
  第20回インテリジェント材料/システムシンポジウム
- Place of Presentation
  東京女子医科大学先端生命医科学研究所
- Year and Date
  2011-01-06
- Data Source
  KAKENHI-PROJECT-20700394
[Presentation] Spontaneous biodegradable polyaspartamide-Asp(DET)-as safe and effective gene carrier2011
- Author(s)
  T.Ishii, K.Itaka, K.Kataoka
- Organizer
  International Conference on Biomaterials Science 2011
- Place of Presentation
  つくば国際会議場
- Year and Date
  2011-03-17
- Data Source
  KAKENHI-PROJECT-20700394
[Presentation] 自己触媒型生分解性を有するポリアミノ酸による遺伝子デリバリー2010
- Author(s)
  石井武彦・位高啓史・片岡一則
- Organizer
  第55回高分子夏季大学
- Place of Presentation
  秋保温泉岩沼屋(仙台市)
- Year and Date
  2010-07-14
- Data Source
  KAKENHI-PROJECT-20700394
[Presentation] 自己触媒型生分解性を有するポリアミノ酸を用いた遺伝子導入と生体適合性評価2010
- Author(s)
  石井武彦・位高啓史・片岡一則
- Organizer
  第39回医用高分子
- Place of Presentation
  東京大学先端科学技術研究センター4号館2階大講堂
- Year and Date
  2010-07-26
- Data Source
  KAKENHI-PROJECT-20700394
[Presentation] 自己触媒型分解機構を有するカチオン性ポリアスパルタミドPAsp(DET)の遺伝子キャリアとしての生体適合性評価2010
- Author(s)
  石井武彦・位高啓史・片岡一則
- Organizer
  第59回高分子討論会
- Place of Presentation
  北海道大学高等教育機能開発総合センター
- Year and Date
  2010-09-14
- Data Source
  KAKENHI-PROJECT-20700394
[Presentation] 生理条件においてポリペプチド主鎖の自己分解を促進するポリアミノ酸の遺伝子デリバリーへの応用2010
- Author(s)
  石井武彦・位高啓史・片岡一則
- Organizer
  第19回ポリマー材料フォーラム
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2010-12-03
- Data Source
  KAKENHI-PROJECT-20700394
[Presentation] 疎水性ドメインにより構造安定化されたPEG化ポリイオンコンプレックスミセルの遺伝子ベクターとしての機能評価2009
- Author(s)
  石井武彦, 他7名
- Organizer
  第25回日本DDS学会
- Place of Presentation
  東京ドームホテル
- Data Source
  KAKENHI-PROJECT-20700394
[Presentation] 疎水性ドメインにより構造安定化されたPEG化ポリイオンコンプレックスミセルの遺伝子ベクータとしての機能評価2009
- Author(s)
  石井武彦・早川佳之・大庭誠・宮田完二朗・比木茂寛・長田健介・片岡一則
- Organizer
  第25回日本DDS学会
- Place of Presentation
  東京ドームホテル
- Year and Date
  2009-07-04
- Data Source
  KAKENHI-PROJECT-20700394
[Presentation] 自己触媒型生分解性を有するポリアミノ酸ベース遺伝子キャリアの生体適合性評価2009
- Author(s)
  石井武彦, 他2名
- Organizer
  第58回高分子討論会
- Place of Presentation
  熊本大学
- Year and Date
  2009-09-18
- Data Source
  KAKENHI-PROJECT-20700394
[Presentation] IGF-1 Gene Delivery by Polyplex Nanomicelle Promotes Neural Function Recovery after Adult PNS Injury on Diabetic Mice
- Author(s)
  Kazuya Nagata, Keiji Itaka, Takehiko Ishii, and Kazunori Kataoka
- Organizer
  40th Annual Meeting & Exposition of the Controlled Release Society
- Place of Presentation
  Hawaii, USA
- Data Source
  KAKENHI-PROJECT-24300170
[Presentation] mRNA生体内デリバリーによる嗅覚神経障害の機能回復
- Author(s)
  位高啓史，馬場美雪，石井武彦，近藤健二，山岨達也，片岡一則
- Organizer
  第29回日本DDS学会学術集会
- Place of Presentation
  京都テルサ（京都市）
- Data Source
  KAKENHI-PROJECT-24300170
[Presentation] Treatment of sensory nerve disorder by in vivo mRNA introduction using polyplex nanomicelle
- Author(s)
  K. Itaka, M. Baba, T. Ishii, and K. Kataoka
- Organizer
  40th Annual Meeting & Exposition of the Controlled Release Society
- Place of Presentation
  Hawaii, USA
- Data Source
  KAKENHI-PROJECT-24300170
[Presentation] mRNAポリプレックスの安定性とその発現持続性に及ぼすポリアスパルタミド側鎖構造の効果
- Author(s)
  内田　寛邦，位高　啓史，宮田　完二郎，石井　武彦, 西山　伸宏，片岡　一則
- Organizer
  第35回日本バイオマテリアル学会大会
- Place of Presentation
  タワーホール船堀（東京都）
- Data Source
  KAKENHI-PROJECT-24300170
[Presentation] In vivo mRNAデリバリーによる嗅覚神経障害モデルの機能回復
- Author(s)
  位高啓史，馬場美雪，石井武彦，近藤健二，山岨達也，片岡一則
- Organizer
  第13回遺伝子・デリバリー研究会シンポジウム
- Place of Presentation
  帝京大学板橋キャンパス（東京都）
- Data Source
  KAKENHI-PROJECT-24300170
[Presentation] 高分子ナノミセルを用いた中枢神経系への安全かつ持続的なmRNA導入
- Author(s)
  内田　智士、位高　啓史、内田　寛邦、石井　武彦，福島　重人、長田　健介、片岡　一則
- Organizer
  第13回遺伝子・デリバリー研究会シンポジウム
- Place of Presentation
  帝京大学板橋キャンパス（東京都）
- Data Source
  KAKENHI-PROJECT-24300170
[Presentation] 骨格筋ターゲット遺伝子導入による末梢神経外傷モデルの早期機能回復
- Author(s)
  長田　和也、位高　啓史、石井　武彦、片岡　一則．
- Organizer
  第13回遺伝子・デリバリー研究会シンポジウム
- Place of Presentation
  帝京大学板橋キャンパス（東京都）
- Data Source
  KAKENHI-PROJECT-24300170
[Presentation] mRNA 肝ターゲットデリバリーへの高分子ナノミセルの応用
- Author(s)
  松井　秋倫，内田　智士，石井　武彦，位高　啓史，片岡　一則
- Organizer
  第35回日本バイオマテリアル学会大会
- Place of Presentation
  タワーホール船堀（東京都）
- Data Source
  KAKENHI-PROJECT-24300170
[Presentation] In vivo mRNA delivery using polyplex nanomicelle with reduced immunological responses
- Author(s)
  S. Uchida, K. Itaka, H. Uchida, K. Hayakawa, T. Ogata, T. Ishii, S. Fukushima, K. Osada, K. Kataoka
- Organizer
  40th Annual Meeting & Exposition of the Controlled Release Society
- Place of Presentation
  Hawaii, USA
- Data Source
  KAKENHI-PROJECT-24300170
[Presentation] フェニルボロン酸を高分子ミセルコアの架橋剤として用いる細胞内環境応答型核酸デリバリーシステムの創出
- Author(s)
  吉永直人、遠藤泰輔、内藤瑞、石井武彦、片岡一則
- Organizer
  第63回高分子学会年次大会
- Place of Presentation
  愛知県名古屋市・名古屋国際会議場
- Year and Date
  2014-05-28 – 2014-05-30
- Data Source
  KAKENHI-PROJECT-25870184
[Presentation] IGF-1発現pDNAの生体適合性キャリアを用いた骨格筋デリバリーによる末梢神経外傷後の早期機能回復
- Author(s)
  長田和也、位高啓史、石井武彦、片岡一則
- Organizer
  第29回日本DDS学会学術集会
- Place of Presentation
  京都テルサ（京都市）
- Data Source
  KAKENHI-PROJECT-24300170
[Presentation] 神経障害の機能再生に向けた新規アプローチ：mRNAの生体内デリバリー
- Author(s)
  位高啓史，馬場美雪，内田智士，石井武彦，近藤健二，山岨達也，片岡一則
- Organizer
  第35回日本バイオマテリアル学会大会
- Place of Presentation
  タワーホール船堀（東京都）
- Data Source
  KAKENHI-PROJECT-24300170

1. ITAKA Keiji (60292926)

# of Collaborated Projects: 3 results

# of Collaborated Products: 21 results
2. KATAOKA Kazunori (00130245)

# of Collaborated Projects: 3 results

# of Collaborated Products: 18 results
3. NISHIYAMA Nobuhiro (10372385)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
4. OSADA Kensuke (10396947)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
5. MIYATA Kanjiro (50436523)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
6. YAMASAKI Yuichi (00322678)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KISHIMURA Akihiro (70422326)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. OGATA Toru (00392192)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. KAWAGUCHI Hiroshi (40282660)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YOKOTA Takanori (90231688)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. TSUMOTO Kouhei (90271866)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. ANRAKU Yasutaka (60581585)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
13. MATSUMOTO Yu (80548553)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
14. UCHIDA Satoshi (20710726)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
15. ZHENG Meng

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Ishii Takehiko 石井 武彦

ISHII Takehiko 石井 武彦

Research Projects

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Co-Researchers

フェニルボロン酸を安定化要素とするリボ核酸送達用高分子ミセルの研究開発Principal Investigator

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Development of Polymeric Micelles for Brain-Targeted Delivery of Nucleic Acid Drugs to Treat Intractable Neurological Diseases

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Development of in vivo mRNA delivery system for treating diseases

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Development of multifunctional polymeric micelles for systemic siRNA delivery

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Preparation of stable supramolecular gene vector in blood and improvement of gene expression efficiencyPrincipal Investigator

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Polymeric micelle nanocarrier for drug and gene delivery

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[Journal Article] Enhanced intracellular delivery of siRNA by controlling ATP-responsivity of phenylboronic acid-functionalized polyion complex micelles.2018

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[Journal Article] Polyplex Micelles with Phenylboronate/Gluconamide Cross-Linking in the Core Exerting Promoted Gene Transfection through Spatiotemporal Responsivity to Intracellular pH and ATP Concentration2017

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[Journal Article] Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain2017

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[Journal Article] Multilayered polyion complexes with dissolvable silica layer covered by controlling densities of cRGD-conjugated PEG chains for cancer-targeted siRNA delivery.2017

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[Journal Article] A facile amino-functionalization of poly (2-oxazoline) s' distal end through sequential azido end-capping and Staudinger reactions.2017

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[Journal Article] Synthetic polyamines to regulate mRNA translation through the preservative binding of eukaryotic initiation factor 4E to the cap structure.2016

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[Journal Article] Polyplex micelles with double-protective compartments of hydrophilic shell and thermo-switchable palisade of poly (oxazoline)-based block copolymers for promoted gene transfection.2016

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[Journal Article] Systemic delivery of messenger RNA for the treatment of pancreatic cancer using polyplex nanomicelles with a cholesterol moiety.2016

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Ishii Takehiko 石井武彦

ISHII Takehiko 石井武彦