Tsuboi Takashi 坪井貴司

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TSUBOI Takashi 坪井貴司

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Researcher Number	80415231
Other IDs
Affiliation (Current)	2025: 東京大学, 大学院総合文化研究科, 教授
Affiliation (based on the past Project Information) *help	2017 – 2024: 東京大学, 大学院総合文化研究科, 教授 2016: 東京大学, 大学院総合文化研究科, 准教授 2010 – 2016: 東京大学, 総合文化研究科, 准教授 2007 – 2010: The University of Tokyo, 大学院・総合文化研究科, 准教授 2006: 独立行政法人理化学研究所, 福田独立主幹研究ユニット, 基礎科学特別研究員
Review Section/Research Field	Principal Investigator General physiology / Basic Section 59040:Nutrition science and health science-related / Medium-sized Section 48:Biomedical structure and function and related fields / Biological Sciences / Science and Engineering Except Principal Investigator Legal medicine / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Biomolecular chemistry / Basic Section 59040:Nutrition science and health science-related / Basic Section 27040:Biofunction and bioprocess engineering-related / Basic Section 46010:Neuroscience-general-related / Functional biochemistry
Keywords	Principal Investigator イメージング / 消化管ホルモン / 開口放出 / 生理学 / 腸内細菌 / 小腸 / 開口分泌 / アストロサイト / ホルモン分泌 / 蛋白質 … More / 生体分子 / 可視化 / フォトトロピン / キナーゼ / ニューロン / 腸内細菌代謝産物 / シグナル伝達 / グレリン / ATP / 細胞内小器官 / 神経・脳 / 分泌顆粒 / 細胞骨格 / バイオイメージング / 神経内分泌細胞 / ホルモン / マイクロRNA / ミオシン2 / ドッキング / Rab / 低分子量GTP蛋白質 / 分泌顆粒輸送 / シナプトタグミン / 小胞輸送 / 全反射蛍光顕微鏡 / 脳・神経 … More Except Principal Investigator マウス / ポリアミン / バイオセンサー / グルコース / GFP / 長期ストレス / ゼノファジー / DNAメチル化 / Fusobacterium nucleatum / コリバクチン産生大腸菌 / 加齢変化 / 性ホルモン / 性腺 / 皮脂腺 / 老化 / 加齢 / ステロイド / 毛包幹細胞 / 表皮幹細胞 / 抗体 / タンパク質工学 / 機械学習 / 腸内環境 / GLP-1 / 認知症 / 脳腸相関 / 腸内細菌 / ホルモン / 腸脳相関 / 腸内細菌叢 / 認知的柔軟性 / 行動状態 / 自発運動 / カルシウム / 受容体 / 性行動 / 神経伝達物質 / ドーパミン / 交尾 / 自発運動量 / 運動量 / 精子 / C. elegans / 性差 / 行動 / バイオイメージング / 蛍光タンパク質 / 人工多能性幹細胞 / 次世代シークエンス / 死後 / ヒト / iPS / レノックス・ガストー症候群 / 法医剖検症例 / 多能性幹細胞 / 慢性ストレス / Robo1 / Arntl / Dbx2 / Zfpm2 / miR－142 family / 慢性的ストレス / miR-142-3p / 長期ストレスマーカー / 高齢者虐待 / 過労死 / マイクロアレイ / 遺伝子発現 / ゲノム / 発現制御 / ストレス応答 / β細胞 / 膵臓 / 転写制御 / ノンコーディングRNA / アンチセンスRNA / ヒストン修飾 / lncRNA / クロマチン / 可視化 / ATP / 心臓突然死 / Human / Mouse / Heart / Apoptosis / Chlorpromazine / 心筋症 / 突然死 / 薬剤 / 下垂体 / Cftr / Sstr4 / Stx11 / MicroArray法 / MtT/S細胞 / 長期虐待 / マーカー / 法医病理学 Less

機械学習を活用したユニバーサルな基盤構造創出による蛍光免疫センサーの迅速開発
- Principal Investigator
  
  北口哲也
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 27040:Biofunction and bioprocess engineering-related
- Research Institution
  Tokyo Institute of Technology
腸内細菌代謝物による認知的柔軟性制御における消化管ホルモンを介した分子機構の解析Principal Investigator
- Principal Investigator
  
  坪井貴司
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  The University of Tokyo
Molecular Mechanisms of Age-Related Skin Diseases Triggered by Age-Related Alterations in the Local Endocrine System of the Skin
- Principal Investigator
  
  原口省吾
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Showa University
New strategy for preventing colorectal cancer by targeting polyamines, which are thought to be carcinogens
- Principal Investigator
  
  松本光晴
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Kyodo Milk Industry Co., Ltd.
ホルモン分泌における環状ヌクレオチドシグナリングを照らすキナーゼ光スイッチ開発Principal Investigator
- Principal Investigator
  
  坪井貴司
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 48:Biomedical structure and function and related fields
- Research Institution
  The University of Tokyo
Elucidation of chemical communication between microbiota and enteroendocrine cellsPrincipal Investigator
- Principal Investigator
  
  坪井貴司
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
Elucidation of the metabolic regulation mechanism of neuronsPrincipal Investigator
- Principal Investigator
  
  坪井貴司
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Strategy for dementia prevention based on the gut microbiota-brain axis on cognitive flexibility
- Principal Investigator
  
  Matsumoto Mitsuharu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Kyodo Milk Industry Co., Ltd.
Regulation of incretin secretion by microbiota metabolitesPrincipal Investigator
- Principal Investigator
  
  TSUBOI Takashi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  The University of Tokyo
Neural mechanisms of sexually dimorphic behavior
- Principal Investigator
  
  Suo Satoshi
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  Saitama Medical University
Microbial regulation of hormone secretion from enteroendocrinePrincipal Investigator
- Principal Investigator
  
  坪井貴司
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  The University of Tokyo
Molecular mechanisms of gastrointestinal hormone secretion by intestinal bacterial metabolitesPrincipal Investigator
- Principal Investigator
  
  TSUBOI Takashi
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  The University of Tokyo
Development of genetically-encoded multi-color biosensors for intracellular signaling
- Principal Investigator
  
  Kitaguchi Tetsuya
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Tokyo Institute of Technology
  Waseda University
Application of miR-142 family expressed only in immune system for chronic stress
- Principal Investigator
  
  IKEMATSU Kazuya
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Legal medicine
- Research Institution
  Nagasaki University
Apply for induced pluripotent stem cells in forensic practice
- Principal Investigator
  
  NAKAHARA Aya
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Legal medicine
- Research Institution
  Nagasaki University
Function and dynamics of stress-induced lncRNA
- Principal Investigator
  
  Ohta Kunihiro
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  The University of Tokyo
Molecular mechanisms of ghrelin secretion from endocrine cellsPrincipal Investigator
- Principal Investigator
  
  TSUBOI Takashi
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  The University of Tokyo
Development of genetically-encoded multi-color ATP sensors for clarification of energy metabolism.
- Principal Investigator
  
  KITAGUCHI TETSUYA
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Waseda University
Diagnosis of Drug Induced arrhythmia
- Principal Investigator
  
  IKEMATSU Kazuya
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Legal medicine
- Research Institution
  Nagasaki University
Mechanisms of gliotransmitter release from astrocytes by imaging analysisPrincipal Investigator
- Principal Investigator
  
  TSUBOI Takashi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
- Research Institution
  The University of Tokyo
The development of the forensic pathological method for diagnosis about chronic stress
- Principal Investigator
  
  TSURUYA Shinitirou
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Legal medicine
- Research Institution
  Nagasaki University
Study on the molecular mechanism of hormone secretionPrincipal Investigator
- Principal Investigator
  
  TSUBOI Takashi
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
- Research Institution
  The University of Tokyo
Molecular mechanisms of hormone release revealed by live cell imaging analysisPrincipal Investigator
- Principal Investigator
  
  TSUBOI Takashi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  General physiology
- Research Institution
  The University of Tokyo
  The Institute of Physical and Chemical Research

[Book] 休み時間の細胞生物学2022
- Author(s)
  坪井貴司
- Total Pages
  192
- Publisher
  講談社
- ISBN
  4065268826
- Data Source
  KAKENHI-PUBLICLY-20H04765
[Book] 休み時間の細胞生物学2022
- Author(s)
  坪井貴司
- Total Pages
  192
- Publisher
  講談社
- ISBN
  4065268826
- Data Source
  KAKENHI-PUBLICLY-20H04836
[Book] 図説生物学2010
- Author(s)
  坪井貴司
- Publisher
  東京大学出版
- Data Source
  KAKENHI-PROJECT-21790197
[Book] 図説生物学「第4章動物の情報処理」「第5章動物の代謝」2010
- Author(s)
  坪井貴司
- Publisher
  東京大学出版
- Data Source
  KAKENHI-PROJECT-21790197
[Book] ベーシックマスター細胞生物学2010
- Author(s)
  坪井貴司
- Publisher
  オーム社
- Data Source
  KAKENHI-PROJECT-21790197
[Book] ベーシックマスター細胞生物学「第6章核と膜小器官」2009
- Author(s)
  坪井貴司
- Publisher
  オーム社
- Data Source
  KAKENHI-PROJECT-21790197
[Journal Article] F‐actin determines the time‐dependent shift in docking dynamics of glucagon‐like peptide‐1 granules upon stimulation of secretion2023
- Author(s)
  Harada Kazuki、Takashima Maoko、Kitaguchi Tetsuya、Tsuboi Takashi
- Journal Title
  
  FEBS Letters
  
  Volume: 597 Issue: 5 Pages: 657-671
- DOI
  10.1002/1873-3468.14580
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H04121
[Journal Article] Development of a red fluorescent protein-based cGMP indicator applicable for live-cell imaging2022
- Author(s)
  Takizawa Mai、Osuga Yuri、Ishida Rika、Mita Marie、Harada Kazuki、Ueda Hiroshi、Kitaguchi Tetsuya、Tsuboi Takashi
- Journal Title
  
  Communications Biology
  
  Volume: 5 Issue: 1 Pages: 833-833
- DOI
  10.1038/s42003-022-03790-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K20659, KAKENHI-PROJECT-20H04121
[Journal Article] Identification of a regulatory pathway of L-phenylalanine-induced GLP-1 secretion in the enteroendocrine L cells2022
- Author(s)
  Osuga Yuri、Harada Kazuki、Tsuboi Takashi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 588 Pages: 118-124
- DOI
  10.1016/j.bbrc.2021.12.043
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-20H04765, KAKENHI-PUBLICLY-20H04836, KAKENHI-PROJECT-20H00575, KAKENHI-PROJECT-20H04121
[Journal Article] Development of red genetically encoded biosensor for visualization of intracellular glucose dynamics2022
- Author(s)
  Mita Marie、Sugawara Izumi、Harada Kazuki、Ito Motoki、Takizawa Mai、Ishida Kentaro、Ueda Hiroshi、Kitaguchi Tetsuya、Tsuboi Takashi
- Journal Title
  
  Cell Chemical Biology
  
  Volume: 29 Issue: 1 Pages: 98-108.e4
- DOI
  10.1016/j.chembiol.2021.06.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K23820, KAKENHI-PUBLICLY-20H04765, KAKENHI-PUBLICLY-20H04836, KAKENHI-PROJECT-18H03851, KAKENHI-PROJECT-20H00575, KAKENHI-PROJECT-20J14411, KAKENHI-PROJECT-20H04121
[Journal Article] Green fluorescent protein-based lactate and pyruvate indicators suitable for biochemical assays and live cell imaging.2020
- Author(s)
  Harada K*, Chihara T*, Hayasaka Y*, Mita M, Takizawa M, Ishida K, Arai M, Tsuno S, Matsumoto M, Ishihara T, Ueda H, Kitaguchi T, Tsuboi T. *Equal contribution
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 1-11
- DOI
  10.1038/s41598-020-76440-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K23820, KAKENHI-PUBLICLY-20H04765, KAKENHI-PUBLICLY-20H04836, KAKENHI-PROJECT-18H03851, KAKENHI-PROJECT-20H04121, KAKENHI-PROJECT-20J14411, KAKENHI-PROJECT-17K08529, KAKENHI-PROJECT-19H03326, KAKENHI-PROJECT-17H06113
[Journal Article] Green Fluorescent Protein-Based Glucose Indicators Report Glucose Dynamics in Living Cells2019
- Author(s)
  Mita Marie、Ito Motoki、Harada Kazuki、Sugawara Izumi、Ueda Hiroshi、Tsuboi Takashi、Kitaguchi Tetsuya
- Journal Title
  
  Analytical Chemistry
  
  Volume: 91 Issue: 7 Pages: 4821-4830
- DOI
  10.1021/acs.analchem.9b00447
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-18H04832, KAKENHI-PROJECT-16J06838, KAKENHI-PROJECT-16K01922, KAKENHI-PROJECT-18H03851
[Journal Article] Bacterial metabolite S-equol modulates glucagon-like peptide-1 secretion from enteroendocrine L cell line GLUTag cells via actin polymerization2018
- Author(s)
  Harada Kazuki、Sada Shoko、Sakaguchi Hidekazu、Takizawa Mai、Ishida Rika、Tsuboi Takashi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 501 Issue: 4 Pages: 1009-1015
- DOI
  10.1016/j.bbrc.2018.05.100
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08529, KAKENHI-PUBLICLY-18H04607
[Journal Article] RGB-Color Intensiometric Indicators to Visualize Spatiotemporal Dynamics of ATP in Single Cells2018
- Author(s)
  Arai Satoshi、Kriszt R?kus、Harada Kazuki、Looi Liang-Sheng、Matsuda Shogo、Wongso Devina、Suo Satoshi、Ishiura Shoichi、Tseng Yu-Hua、Raghunath Michael、Ito Toshiro、Tsuboi Takashi、Kitaguchi Tetsuya
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 57 Issue: 34 Pages: 10873-10878
- DOI
  10.1002/anie.201804304
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01922, KAKENHI-PROJECT-16K07063, KAKENHI-PROJECT-16J06838, KAKENHI-PROJECT-16H06044
[Journal Article] Bitter tastant quinine modulates glucagon-like peptide-1 exocytosis from clonal GLUTag enteroendocrine L cells via actin reorganization2018
- Author(s)
  Harada Kazuki、Sakaguchi Hidekazu、Sada Shoko、Ishida Rika、Hayasaka Yuki、Tsuboi Takashi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 500 Issue: 3 Pages: 723-730
- DOI
  10.1016/j.bbrc.2018.04.143
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08529
[Journal Article] Transient receptor potential ankyrin 1 channels are involved in spontaneous peptide hormone release from astrocytes2018
- Author(s)
  Takizawa Mai、Harada Kazuki、Nakamura Kazuaki、Tsuboi Takashi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 501 Issue: 4 Pages: 988-995
- DOI
  10.1016/j.bbrc.2018.05.097
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07072, KAKENHI-PROJECT-17K08529
[Journal Article] Generation of a cGMP indicator with an expanded dynamic range by optimization of amino acid linkers between a fluorescent protein and PDE5α.2017
- Author(s)
  Matsuda S, Harada K, Ito M, Takizawa M, Wongso D, Tsuboi T, Kitaguchi T
- Journal Title
  
  ACS Sensors
  
  Volume: 2 Issue: 1 Pages: 46-57
- DOI
  10.1021/acssensors.6b00582
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460289, KAKENHI-PROJECT-26291018, KAKENHI-PROJECT-16K01922
[Journal Article] Red fluorescent protein-based cAMP indicator applicable to optogenetics and in vivo imaging2017
- Author(s)
  Harada Kazuki、Ito Motoki、Wang Xiaowen、Tanaka Mika、Wongso Devina、Konno Ayumu、Hirai Hirokazu、Hirase Hajime、Tsuboi Takashi、Kitaguchi Tetsuya
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 7351-7351
- DOI
  10.1038/s41598-017-07820-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01922, KAKENHI-PROJECT-15H04254, KAKENHI-PROJECT-16J06838, KAKENHI-PROJECT-26460289, KAKENHI-PROJECT-16K15477, KAKENHI-PROJECT-15K18330
[Journal Article] Lysophosphatidylinositol-induced activation of the cation channel TRPV2 triggers glucagon-like peptide-1 secretion in enteroendocrine L cells2017
- Author(s)
  Kazuki Harada、 Tetsuya Kitaguchi、 Taichi Kamiya、 Kyaw Htet Aung、 Kazuaki Nakamura、 Kunihiro Ohta and Takashi Tsuboi
- Journal Title
  
  J. Biol. Chem
  
  Volume: 292 Issue: 26 Pages: 10855-10864
- DOI
  10.1074/jbc.m117.788653
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26291018, KAKENHI-PLANNED-17H06380, KAKENHI-PROJECT-26460289, KAKENHI-PROJECT-17H03711
[Journal Article] Wide and high resolution tension measurement using FRET in embryo.2016
- Author(s)
  Satoshi Yamashita, Takashi Tsuboi, Nanako Ishinabe, Tetsuya Kitaguchi, Tatsuo Michiue
- Journal Title
  
  Scientific Reports
  
  Volume: 該当なし Issue: 1 Pages: 28535-28535
- DOI
  10.1038/srep28535
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15J10195, KAKENHI-PROJECT-26440115, KAKENHI-PROJECT-26460289, KAKENHI-PROJECT-26291018
[Journal Article] Gliotransmitter release from astrocytes: functional, developmental and pathological implications in the brain2016
- Author(s)
  Kazuki Harada, Taichi Kamiya, Takashi Tsuboi
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 9 Pages: 499-499
- DOI
  10.3389/fnins.2015.00499
- Open Access
- Data Source
  KAKENHI-PROJECT-26460289, KAKENHI-PROJECT-26291018
[Journal Article] Y-maze avoidance: an automated and rapid associative learning paradigm in zebrafish.2015
- Author(s)
  Aoki R, Tsuboi T, Okamoto H.
- Journal Title
  
  Neurosci Res.
  
  Volume: 91 Pages: 69-72
- DOI
  10.1016/j.neures.2014.10.012
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23120008, KAKENHI-PROJECT-26460289, KAKENHI-PROJECT-26291018
[Journal Article] Integrative function of adrenaline receptors for glucagon-like peptide-1 exocytosis in enteroendocrine L cell line GLUTag2015
- Author(s)
  Kazuki Harada, Tetsuya Kitaguchi, Takashi Tsuboi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 印刷中 Issue: 4 Pages: 1053-1058
- DOI
  10.1016/j.bbrc.2015.03.151
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460289, KAKENHI-PROJECT-26291018
[Journal Article] Low glucose-induced ghrelin secretion is mediated by ATP-sensitive potassium channel.2015
- Author(s)
  Manami Oya, Tetsuya Kitaguchi, Kazuki Harada, Rika Numano, Takahiro Sato, Masayasu Kojima and Takashi Tsuboi.
- Journal Title
  
  J Endocrinol
  
  Volume: 226 Issue: 1 Pages: 25-34
- DOI
  10.1530/joe-15-0090
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25350970, KAKENHI-PROJECT-26460289, KAKENHI-PROJECT-26650025, KAKENHI-PROJECT-26291018
[Journal Article] Live-cell imaging of vesicle trafficking and divalent metal ions by total internal reflection fluorescence (TIRF) microscopy.2013
- Author(s)
  Loder MK, Tsuboi T, Rutter GA.
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 950 Pages: 13-26
- DOI
  10.1007/978-1-62703-137-0_2
- ISBN
  9781627031363, 9781627031370
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790207
[Journal Article] The G-protein-coupled receptor family C group 6 subtype A (GPRC6A) receptor is involved in amino acid-induced glucagon-like peptide-1 secretion from GLUTag cells2013
- Author(s)
  Oya M, Kitaguchi T, Pais R, Reimann F, Gribble F, Tsuboi T
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 288 Issue: 7 Pages: 4513-4521
- DOI
  10.1074/jbc.m112.402677
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790207
[Journal Article] Extracellular calcium influx activates adenylate cyclase 1 and potentiates insulin secretion in MIN6 cells2013
- Author(s)
  Kitaguchi T, Oya M, Wada Y, Tsuboi T, Miyawaki A
- Journal Title
  
  Biochemical Journal
  
  Volume: 450 Issue: 2 Pages: 365-373
- DOI
  10.1042/bj20121022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790207
[Journal Article] Vesicular nucleotide transporter is involved in ATP storage of secretory lysosomes in astrocytes.2013
- Author(s)
  Manami Oya
- Journal Title
  
  Biochemical Biophysical Research Communications.
  
  Volume: 438 Issue: 1 Pages: 145-151
- DOI
  10.1016/j.bbrc.2013.07.043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J08221, KAKENHI-PROJECT-21671002, KAKENHI-PROJECT-24790207, KAKENHI-PROJECT-25350970
[Journal Article] Dual roles of Notch in regulation of apically restricted mitosis and apicobasal polarity of neuroepithelial cells.2011
- Author(s)
  Ohata S, Aoki R, Kinoshita S, Yamaguchi M, Tsuruoka-Kinoshita S, Tanaka H, Wada H, Watabe S, Tsuboi T, Masai I, Okamoto H.
- Journal Title
  
  Neuron 69
  
  Pages: 215-230
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790197
[Journal Article] Dual roles of Notch in regulation of apically restricted mitosis and apicobasal polarity of neuroepithelial cells2011
- Author(s)
  Ohata S, Aoki R, Kinoshita S, Yamaguchi M, Tsuruoka-Kinoshita S, Tanaka H, Wada H, Watabe S, Tsuboi T, Masai I, Okamoto H
- Journal Title
  
  Neuron
  
  Volume: 69 Pages: 215-230
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790197
[Journal Article] Development of Luciferin Analogues Bearing an Amino Group and Their Application as BRET Donors2010
- Author(s)
  Takakura H, Sasakura K, Ueno T, Urano Y, Terai T, Hanaoka K, Tsuboi T, Nagano T
- Journal Title
  
  Chemistry-An Asian Journal
  
  Volume: 5 Pages: 2053-2061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790197
[Journal Article] Duration of fusion pore opening and the amount of hormone released are regulated by myosin II during kiss-and-run exocytosis2010
- Author(s)
  Aoki R, Kitaguchi T, Oya M, Yanagihara Y, Sato M, Miyawaki A, Tsuboi T.
- Journal Title
  
  Biochemical Journal 429
  
  Pages: 497-504
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790197
[Journal Article] Role of the polybasic sequence in the Doc2alpha C2B domain in dense-core vesicle exocytosis in PC12 cells2010
- Author(s)
  Sato M, Mori Y, Matsui T, Aoki R, Oya M, Yanagihara Y, Fukuda M, Tsuboi T
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 114 Pages: 171-181
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790197
[Journal Article] Role of the polybasic sequence in the Doc2alpha C2B domain in dense-core vesicle exocytosis in PC12 cells.2010
- Author(s)
  Sato M, Mori Y, Matsui T, Aoki R, Oya M, Yanagihara Y, Fukuda M, Tsuboi T.
- Journal Title
  
  Journal of Neurochemistry 114
  
  Pages: 171-181
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790197
[Journal Article] Miyawaki A Age-dependent preferential secretory vesicle exocytosis in neuroendocrine cells2010
- Author(s)
  Tsuboi T, Kitaguchi T, Karasawa S, Fukuda M
- Journal Title
  
  The Journal of Physiological Sciences 60
  
  Pages: 11-11
- Data Source
  KAKENHI-PROJECT-21790197
[Journal Article] Age-dependent preferential dense-core vesicle exocytosis in neuroendocrine cells revealed by newly developed monomeric fluorescent timer protein2010
- Author(s)
  Tsuboi T, Kitaguchi T, Karasawa S, Fukuda M, Miyawaki A.
- Journal Title
  
  Molecular Biology of the Cell 21
  
  Pages: 87-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790197
[Journal Article] Development of Luciferin Analogues Bearing an Amino Group and Their Application as BRET Donors Chemistry-An2010
- Author(s)
  Takakura H, Sasakura K, Ueno T, Urano Y, Terai T, Hanaoka K, Tsuboi T, Nagano T.
- Journal Title
  
  Asian Journal 5
  
  Pages: 2053-2061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790197
[Journal Article] Age-dependent preferential dense-core vesicle exocytosis in neuroendocrine cells revealed by newly developed monomeric fluorescent timer protein.2010
- Author(s)
  Tsuboi T, Kitaguchi T, Karasawa S, Fukuda M, Miyawaki A.
- Journal Title
  
  Molecular Biology of the Cell 21
  
  Pages: 87-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790197
[Journal Article] Golgi-associated GSK3-beta regulates the sorting process of post-Golgi membrane trafficking.2010
- Author(s)
  Adachi A, Kano F, Tsuboi T, Fujita M, Maeda Y, Murata M.
- Journal Title
  
  Journal of Cell Sciences 123
  
  Pages: 3215-3225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790197
[Journal Article] Molecular mechanism of glutamate-induced insulin secretion from pancreatic b-cells revealed by genetically encoded fluorescent indicators2010
- Author(s)
  Oya M, Sato M, Suzuki H, Sato M, Tsuboi T.
- Journal Title
  
  The Journal of Physiological Sciences 60
  
  Pages: 175-175
- Data Source
  KAKENHI-PROJECT-21790197
[Journal Article] Duration of fusion pore opening and the amount of hormone released are regulated by myosin II during kiss-and-run exocytosis2010
- Author(s)
  Aoki R, Kitaguchi T, Oya M, Yanagihara Y, Sato M, Miyawaki A, Tsuboi T
- Journal Title
  
  Biochemical Journal
  
  Volume: 429 Pages: 497-504
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790197
[Journal Article] Effect of glucocorticoid on the biosynthesis of growth hormone-containing secretory granules in pituitary cells.2010
- Author(s)
  Kawashima R, Ikematsu K, Abe Y, Sato M, Tsuruya S, Nakasono I, Fukushima H, Inoue K, Tsuboi T.
- Journal Title
  
  Biochemical and Biophysical Research Communications 400
  
  Pages: 225-229
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790197
[Journal Article] Effect of glucocorticoid on the biosynthesis of growth hormone-containing secretory granules in pituitary cells2010
- Author(s)
  Kawashima R, Ikematsu K, Abe Y, Sato M, Tsuruya S, Nakasono I, Fukushima H, Inoue K, Tsuboi T
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 400 Pages: 225-229
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790197
[Journal Article] Myosin II modulates fusion pore opening period via cortical F-actin reorganization2010
- Author(s)
  Aoki R, Kitaguchi T, Miyawaki A, Tsuboi T.
- Journal Title
  
  The Journal of Physiological Sciences 60
  
  Pages: 176-176
- Data Source
  KAKENHI-PROJECT-21790197
[Journal Article] Golgi-associated GSK3-beta regulates the sorting process of post-Golgi membrane trafficking2010
- Author(s)
  Adachi A, Kano F, Tsuboi T, Fujita M, Maeda Y, Murata M
- Journal Title
  
  Journal of Cell Science
  
  Volume: 123 Pages: 3215-3225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790197
[Journal Article] Regulation of the intracellular distribution, cell surface expression, and protein levels of AMPA receptor GluR2 subunits by the monocarboxylate transporter MCT2 in neuronal cells2009
- Author(s)
  Maekawa F, Tsuboi T, Pellerin L
- Journal Title
  
  Journal of Neurochemistry (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689008
[Journal Article] Molecular mechanism of attachment process of dense-core vesicles to the plasma membrane in neuroendocrine cells2009
- Author(s)
  Tsuboi T
- Journal Title
  
  Neuroscience Research 63
  
  Pages: 83-88
- NAID
  10027499443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790197
[Journal Article] Molecular mechanism of attachment process of dense-core vesicles to the plasma membrane in neuroendocrine cells2009
- Author(s)
  Tsuboi T
- Journal Title
  
  Neuroscience Research 63
  
  Pages: 83-88
- NAID
  10027499443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689008
[Journal Article] Neuroepithelial cells require fucosylated glycans to guide the migration of vagus motor neuron progenitors in the developing zebrafish hindbrain.2009
- Author(s)
  Ohata S, Kinoshita S, Aoki R, Tanaka H, Wada H, Tsuruoka-Kinoshita S, Tsuboi T, Watabe S, Okamoto H.
- Journal Title
  
  Development 136
  
  Pages: 1653-1663
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790197
[Journal Article] Molecular mechanism of attachment process of dense-core vesicles to the plasma membrane in neuroendocrine cells.2009
- Author(s)
  Tsuboi T.
- Journal Title
  
  Neuroscience Research 63
  
  Pages: 83-88
- NAID
  10027499443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790197
[Journal Article] Regulation of the intracellular distribution, cell surface expression, and protein levels of AMPA receptor GluR2 subunits by the monocarboxylate transporter MCT2 in neuronal cells.2009
- Author(s)
  Maekawa F, Tsuboi T, Fukuda M, Pellerin L.
- Journal Title
  
  Journal of Neurochemistry 109
  
  Pages: 1767-1778
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790197
[Journal Article] Regulation of the intracellular distribution, cell surface expression, and protein levels of AMPA receptor GluR2 subunits by the monocarboxylate transporter MCT2 in neuronal cells2009
- Author(s)
  Maekawa F, Tsuboi T, Fukuda M, Pellerin L.
- Journal Title
  
  Journal of Neurochemistry 109
  
  Pages: 1767-1778
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790197
[Journal Article] Monocarboxylate transporter-2 (MCT2) regulates subcellular localization and surface expression of glutamate receptor-2 (GluR2).2009
- Author(s)
  Maekawa F, Tsuboi T, Yada T, Pellerin L.
- Journal Title
  
  The Journal of Physiological Sciences 59
  
  Pages: 136-136
- Data Source
  KAKENHI-PROJECT-21790197
[Journal Article] Neuroepithelial cells require fucosylated glycans to guide the migration of vagus motor neuron progenitors in the developing zebrafish hindbrain2009
- Author(s)
  Ohata S, Kinoshita S, Aoki R, Tanaka H, Wada H, Tsuruoka-Kinoshita S, Tsuboi T, Watabe S, Okamoto H
- Journal Title
  
  Development (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689008
[Journal Article] Myosin II regulates "kiss-and-run" dense-core exocytosis revealed by total internal reflection fluorescence microscopy.2009
- Author(s)
  Aoki R, Kitaguchi T, Tsuboi T.
- Journal Title
  
  The Journal of Physiological Sciences 59
  
  Pages: 301-301
- Data Source
  KAKENHI-PROJECT-21790197
[Journal Article] Neuroepithelial cells require fucosylated glycans to guide the migration of vagus motor neuron progenitors in the developing zebrafish hindbrain2009
- Author(s)
  Ohata S, Kinoshita S, Aoki R, Tanaka H, Wada H, Tsuruoka-Kinoshita S, Tsuboi T, Watabe S, Okamoto H
- Journal Title
  
  Development 136
  
  Pages: 1653-1663
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790197
[Journal Article] Imaging a target of Ca^<2+> signalling: Dense core granule exocytosis viewed by total internal reflection fluorescence microscopy2008
- Author(s)
  Ravier MA, Tsuboi T, Rutter GA
- Journal Title
  
  Methods 46
  
  Pages: 233-238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689008
[Journal Article] Rabphilin directly interacts with SNAP-25 and regulates the docking step of dense-core vesicle exocytosis in PC12 cells2008
- Author(s)
  Tsuboi T
- Journal Title
  
  The Journal of Physiological Sciences 58 (Suppl.)
- NAID
  130005449384
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689008
[Journal Article] Molecular mechanism of docking of dense-core vesicles to the plasma membrane in neuroendocrine cells2008
- Author(s)
  Tsuboi T
- Journal Title
  
  Medical Molecular Morphology 41
  
  Pages: 68-75
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689008
[Journal Article] Rabphilin directly interacts with SNAP-25 and regulates the docking step of densecore vesicle exocytosis in PC12 cells2008
- Author(s)
  Tsuboi T
- Journal Title
  
  The Journal of Physiological Sciences 58(suppl.)
- Data Source
  KAKENHI-PROJECT-18689008
[Journal Article] Imaging a target of Ca2+ signalling: Dense core granule exocytosis viewed by totalinternal reflection fluorescence microscopy2008
- Author(s)
  Ravier MA, Tsuboi T, Rutter GA
- Journal Title
  
  Methods 46
  
  Pages: 233-238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689008
[Journal Article] Molecular mechanism of docking of dense-core vesicle to the plasma membrane in neuroendocrine cells2008
- Author(s)
  Tsuboi T
- Journal Title
  
  Medical Molecular Morphology 41(2)
  
  Pages: 68-75
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689008
[Journal Article] Role for synaptotagmin VII in fusion pore dynamics revealed by total Internal reflection fluorescence microscopy2007
- Author(s)
  Tsuboi T, 他1名
- Journal Title
  
  Neuroscience Research 58(suppl.1)
- Data Source
  KAKENHI-PROJECT-18689008
[Journal Article] Synaptotagmin VII modulates the kinetics of dense-core vesicle exocytosis in PC12 cells.2007
- Author(s)
  Tsuboi T, 他1名
- Journal Title
  
  Genes to Cells 12
  
  Pages: 511-519
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689008
[Journal Article] The polybasic sequence in the C2B domain of rabphilin is required for the vesicle docking step in PC12 cells2007
- Author(s)
  Tsuboi T, Kanno E, Fukuda M
- Journal Title
  
  Journal of Neurochemistry 100
  
  Pages: 770-779
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689008
[Journal Article] The polybasic sequence in the C2B domain of rabphilin is required for the vesicle docking step in PC12 cells.2007
- Author(s)
  Tsuboi T, 他2名
- Journal Title
  
  Journal of Neurochemistry 100
  
  Pages: 770-779
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689008
[Journal Article] Live cell imagingによる細胞活動の可視化解析2007
- Author(s)
  坪井貴司, 他1名
- Journal Title
  
  日本比較内分泌学会ニュース 124
  
  Pages: 45-53
- NAID
  10018293579
- Data Source
  KAKENHI-PROJECT-18689008
[Journal Article] Synaptotagmin VII modulates the kinetics of dense-core vesicle exocytosis in PC12 cells2007
- Author(s)
  Tsuboi T, Fukuda M
- Journal Title
  
  Genes to Cells 12
  
  Pages: 511-519
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689008
[Journal Article] Live cell imagingによる細胞活動の可視化解析2007
- Author(s)
  坪井貴司
- Journal Title
  
  日本比較内分泌学会ニュース 124
  
  Pages: 45-53
- NAID
  10018293579
- Data Source
  KAKENHI-PROJECT-18689008
[Journal Article] Role for synaptotagmin VII in fusion pore dynamics revealed by total internal reflection fluorescence microscopy2007
- Author(s)
  Tsuboi T, Fukuda M
- Journal Title
  
  Neuroscience Research 58 (suppl.1)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689008
[Journal Article] Sustained exposure to high glucose concentrations modifies glucose signaling and the mechanics of secretory vesicle fusion in primary rat pancreatic beta-cells2006
- Author(s)
  Tsuboi T, Ravier MA, Parton LE, Rutter GA
- Journal Title
  
  Diabetes 55
  
  Pages: 1057-1065
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689008
[Journal Article] Insulin secretion in health and disease: genomics, proteomics and single vesicle dynamics2006
- Author(s)
  Rutter GA, Varadi A, Tsuboi T, Parton LE, Ravier MA
- Journal Title
  
  Biochemical Society Transactions 34
  
  Pages: 247-250
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689008
[Journal Article] Rab3A and Rab27A cooperatively regulate the docking step of dense-core vesicle exocytosis in PC12 cells2006
- Author(s)
  Tsuboi T, Fukuda M
- Journal Title
  
  Journal of Cell Science 119
  
  Pages: 2196-2203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689008
[Journal Article] Sustained exposure to high glucose concentrations modifies glucose signaling and the mechanics of secretory vesicle fusion in primary rat pancreatic beta cells2006
- Author(s)
  Tsuboi T et al.
- Journal Title
  
  Diabetes 55
  
  Pages: 1057-1065
- Data Source
  KAKENHI-PROJECT-18689008
[Journal Article] The Slp4-a linker domain controls exocytosis through interaction with Munc18-1-syntaxin-1a complex2006
- Author(s)
  Tsuboi T, Fukuda M
- Journal Title
  
  Molecular Biology of the Cell 17
  
  Pages: 2101-2112
- NAID
  120002338802
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689008
[Journal Article] The Slp4-a linker domain controls exocytosis through interaction with Munc18-1-syntaxin-1a complex.2006
- Author(s)
  Tsuboi T et al.
- Journal Title
  
  Molecular Biology of the Cell 17
  
  Pages: 2101-2112
- NAID
  120002338802
- Data Source
  KAKENHI-PROJECT-18689008
[Journal Article] Rab3A and Rab27A cooperatively regulate the docking of dense-core vesicle2006
- Author(s)
  Tsuboi T, Fukuda M
- Journal Title
  
  Neuroscience Research 55 (suppl. 1)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689008
[Journal Article] Ca^<2+> microdomains and the control of insulin secretion2006
- Author(s)
  Rutter GA, Tsuboi T, Ravier MA
- Journal Title
  
  Cell Calcium 40
  
  Pages: 539-551
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689008
[Journal Article] Rab3A and Rab27A cooperatively regulate the docking step of dense-core vesicle exocytosis in PC12 cells.2006
- Author(s)
  Tsuboi T et al.
- Journal Title
  
  Journal of Cell Science 119
  
  Pages: 2196-2203
- Data Source
  KAKENHI-PROJECT-18689008
[Patent] リガンド蛍光センサータンパク質とその使用2016
- Inventor(s)
  北口哲也、坪井貴司、上田宏、新井敏
- Industrial Property Rights Holder
  北口哲也、坪井貴司、上田宏、新井敏
- Industrial Property Rights Type
  特許
- Filing Date
  2016-12-02
- Overseas
- Data Source
  KAKENHI-PROJECT-16K01922
[Patent] 「リガンド蛍光センサータンパク質とその使用」2016
- Inventor(s)
  北口哲也、坪井貴司、上田宏
- Industrial Property Rights Holder
  北口哲也、坪井貴司、上田宏
- Industrial Property Rights Type
  特許
- Filing Date
  2016-12-02
- Overseas
- Data Source
  KAKENHI-PROJECT-25350970
[Patent] リガンド蛍光センサータンパク質とその使用2016
- Inventor(s)
  北口哲也、坪井貴司、上田宏
- Industrial Property Rights Holder
  北口哲也、坪井貴司、上田宏
- Industrial Property Rights Type
  特許
- Filing Date
  2016-05-24
- Overseas
- Data Source
  KAKENHI-PROJECT-16K01922
[Patent] ATP蛍光センサータンパク質2015
- Inventor(s)
  北口哲也、新井敏、坪井貴司
- Industrial Property Rights Holder
  北口哲也、新井敏、坪井貴司
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-237524
- Filing Date
  2015-12-04
- Data Source
  KAKENHI-PROJECT-25350970
[Presentation] 腸内細菌叢と消化管内分泌細胞との機能連関.2021
- Author(s)
  坪井貴司
- Organizer
  第74回日本自律神経学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-20H04121
[Presentation] 腸内細菌叢と消化管内分泌細胞との機能連関2021
- Author(s)
  坪井貴司
- Organizer
  第74回日本自律神経学会総会
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H04836
[Presentation] 腸内細菌叢と消化管内分泌細胞との機能連関2021
- Author(s)
  坪井貴司
- Organizer
  日本化学会第101春季大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H04836
[Presentation] .L-フェニルアラニンによるグルカゴン様ペプチド-1分泌調節機構2021
- Author(s)
  大須賀佑里, 原田一貴, 坪井貴司
- Organizer
  第44回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-20H04121
[Presentation] 腸内細菌叢と消化管内分泌細胞との機能連関2021
- Author(s)
  坪井貴司
- Organizer
  日本化学会第101春季大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H04765
[Presentation] 腸内細菌叢と消化管内分泌細胞との機能連関2021
- Author(s)
  坪井貴司
- Organizer
  第74回日本自律神経学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-20H00575
[Presentation] 腸内細菌叢と消化管内分泌細胞との機能連関.2021
- Author(s)
  坪井貴司
- Organizer
  第74回日本自律神経学会総会
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H04765
[Presentation] 腸内細菌叢と消化管内分泌細胞との機能連関2021
- Author(s)
  坪井貴司
- Organizer
  日本化学会第101春季大会
- Invited
- Data Source
  KAKENHI-PROJECT-20H04121
[Presentation] C. elegansにおいてTGFβ経路はドーパミンによる性特異的な運動量の制御に関与する2020
- Author(s)
  周防諭, 原田一貴, 丸山敬, 坪井貴司
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K06911
[Presentation] 蛍光タンパク質を用いた緑色蛍光輝度変化型乳酸センサーの開発2019
- Author(s)
  千原貴美、三田真理恵、菅原和、相木彩希、早坂優希、原田一貴、上田宏、北口哲也、坪井貴司
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K01922
[Presentation] Molecular mechanisms of deoxycholic acid induced glucaton-like peptide-1 secretion2019
- Author(s)
  Maoko Takashima, Kazuki Harada, Taichi Kamiya, Takashi Tsuboi
- Organizer
  第9回アジア・オセアニア生理学会連合大会
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04607
[Presentation] Bitter tastant and bacterial metabolite modulate glucagon-like peptide-1 secretion2019
- Author(s)
  Kazuki Harada, Hidekazu Sakaguchi, Shoko Sada, Takashi Tsuboi
- Organizer
  第9回アジア・オセアニア生理学会連合大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08529
[Presentation] Molecular mechanisms of deoxycholic acid induced glucaton-like peptide-1 secretion2019
- Author(s)
  Maoko Takashima, Kazuki Harada, Taichi Kamiya, Takashi Tsuboi
- Organizer
  第9回アジア・オセアニア生理学会連合大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08529
[Presentation] 緑色蛍光グルコースセンサーが検出する人工甘味料による膵β細胞のグルコース恒常性攪乱2019
- Author(s)
  三田真理恵、伊藤幹、原田一貴、菅原和、永田怜、芦田翼、上田宏、坪井貴司、北口哲也
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K01922
[Presentation] L-グルタミンによるアミノ酸受容体を介したグルカゴン様ペプチド-1分泌制御機構の解明2019
- Author(s)
  原田一貴, 中村匠, 神谷泰智, 滝澤舞, 中島一夫，北口哲也，太田邦史, 坪井貴司
- Organizer
  日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K08529
[Presentation] Sexually dimorphic dopaminergic signaling regulates behavioral states of C. elegans2019
- Author(s)
  Suo, S., Harada, K., Matsuda, S., Kyo, K., Wang, M., Maruyama, K., Awaji, T., Tsuboi, T.
- Organizer
  International C. elegans Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06911
[Presentation] 腸内環境感受による消化管ホルモン分泌調節機構2019
- Author(s)
  坪井貴司
- Organizer
  うま味研究会
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04607
[Presentation] L-グルタミンによるアミノ酸受容体を介したグルカゴン様ペプチド-1分泌制御機構の解明2019
- Author(s)
  原田一貴, 中村匠, 神谷泰智, 滝澤舞, 中島一夫，北口哲也，太田邦史, 坪井貴司
- Organizer
  日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04607
[Presentation] Bitter tastant and bacterial metabolite modulate glucagon-like peptide-1 secretion2019
- Author(s)
  Kazuki Harada, Hidekazu Sakaguchi, Shoko Sada, Takashi Tsuboi
- Organizer
  第9回アジア・オセアニア生理学会連合大会
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04607
[Presentation] ドーパミンは線虫C. elegansの運動量の性差を生み出す.2019
- Author(s)
  周防諭、原田一貴、松田翔吾、姜興起、王旻、丸山敬、淡路健雄、坪井貴司
- Organizer
  Neuro2019 日本神経科学会大会・日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-19K06911
[Presentation] 生細胞内のグルコース動態を検出する遺伝子コード型緑色蛍光センサーの創出2019
- Author(s)
  三田真理恵、伊藤幹、原田一貴、菅原和、上田宏、坪井貴司、北口哲也
- Organizer
  2019年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-16K01922
[Presentation] 腸内環境感受による消化管ホルモン分泌調節機構2019
- Author(s)
  坪井貴司
- Organizer
  うま味研究会公開シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17K08529
[Presentation] 赤色蛍光グルコースセンサーによる細胞内グルコース動態の可視化2018
- Author(s)
  菅原和、伊藤幹、三田真理恵、上田宏、坪井貴司、北口哲也
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K01922
[Presentation] Single fluorescent protein-based sensors visualize dynamics of glucose by live cell imaging.2018
- Author(s)
  Marie Mita, Motoki Ito, Kazuki Harada, Izumi Sugawara, Hiroshi Ueda, Takashi Tsuboi and Tetsuya Kitaguchi.
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K01922
[Presentation] Turn-on型の高輝度変化率を有する緑色cAMPセンサーの開発2018
- Author(s)
  相木彩希、上田宏、北口哲也、坪井貴司
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K01922
[Presentation] 小腸内分泌L細胞に対する苦味物質および腸内細菌代謝産物の消化管ホルモン分泌への影響2018
- Author(s)
  原田一貴、阪口秀和、佐田尚子、坪井貴司
- Organizer
  第248回生理学東京談話会
- Data Source
  KAKENHI-PUBLICLY-18H04607
[Presentation] 緑色蛍光タンパク質を用いたピルビン酸センサーの開発2018
- Author(s)
  早坂優希、上田宏、北口哲也、坪井貴司
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K01922
[Presentation] 小腸内分泌L細胞に対する苦味物質および腸内細菌代謝産物の消化管ホルモン分泌への影響2018
- Author(s)
  原田一貴、阪口秀和、佐田尚子、坪井貴司
- Organizer
  第248回生理学東京談話会
- Data Source
  KAKENHI-PROJECT-17K08529
[Presentation] 赤色蛍光タンパク質を用いたcGMP蛍光センサーの生細胞イメージングへの応用2018
- Author(s)
  石田りか、三田真理恵、原田一貴、上田宏、北口哲也、坪井貴司
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K01922
[Presentation] 遺伝子コード型蛍光センサーによるホルモン分泌機構研究2017
- Author(s)
  坪井貴司
- Organizer
  第90回日本内分泌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-26460289
[Presentation] 蛍光タンパク質を用いた単色型グルコース可視化センサーの開発2017
- Author(s)
  三田真理恵、伊藤幹、原田一貴、上田宏、坪井貴司、北口哲也
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K01922
[Presentation] グルタミン誘導性グルカゴン様ペプチド-1分泌機構の解析2017
- Author(s)
  神谷泰智, 原田一貴, 坪井貴司
- Organizer
  第94回日本生理学会大会
- Place of Presentation
  オークラアクトシティー浜松（静岡県浜松市）
- Data Source
  KAKENHI-PROJECT-26460289
[Presentation] 新規cAMP可視化赤色蛍光タンパク質の開発と応用2017
- Author(s)
  原田一貴，伊藤幹，Xiaowen Wang，田中三佳，Devina Wongso，平瀬肇，坪井貴司，北口哲也
- Organizer
  第94回日本生理学会大会
- Place of Presentation
  オークラアクトシティー浜松（静岡県浜松市）
- Data Source
  KAKENHI-PROJECT-26460289
[Presentation] 赤色蛍光タンパク質を用いたcGMP蛍光センサーの開発2017
- Author(s)
  石田りか、三田真理恵、原田一貴、上田宏、北口哲也、坪井貴司
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K01922
[Presentation] アストロサイトからのグリア伝達物質放出メカニズムの可視化解析.2017
- Author(s)
  滝澤舞, 原田一貴, 坪井貴司
- Organizer
  第94回日本生理学会大会
- Place of Presentation
  オークラアクトシティー浜松（静岡県浜松市）
- Year and Date
  2017-03-29
- Data Source
  KAKENHI-PROJECT-26291018
[Presentation] グルカゴン様ペプチド-1分泌小腸内分泌L細胞に対するS-エクオールの効果2017
- Author(s)
  佐田尚子, 神谷泰智, 原田一貴，坪井貴司
- Organizer
  第94回日本生理学会大会
- Place of Presentation
  オークラアクトシティー浜松（静岡県浜松市）
- Year and Date
  2017-03-30
- Data Source
  KAKENHI-PROJECT-26291018
[Presentation] リゾフォスファチジルイノシトールによるグルカゴン様ペプチド-1分泌機構2017
- Author(s)
  原田一貴, 北口哲也, 神谷泰智, Aung Htet Kyaw, 中村和昭, 太田邦史, 坪井貴司
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-26460289
[Presentation] グルタミン誘導性グルカゴン様ペプチド-1分泌機構の解析2017
- Author(s)
  神谷泰智, 原田一貴, 坪井貴司
- Organizer
  第94回日本生理学会大会
- Place of Presentation
  オークラアクトシティー浜松（静岡県浜松市）
- Year and Date
  2017-03-30
- Data Source
  KAKENHI-PROJECT-26291018
[Presentation] A red fluorescent protein-based cAMP indicator for dual color imaging, optogenetic manipulations and in vivo imaging.2017
- Author(s)
  Kazuki Harada, Motoki Ito, Xiaowen Wang, Mika Tanaka, Devina Wongso, Hajime Hirase, Takashi Tsuboi and Tetsuya Kitaguchi.
- Organizer
  第94回日本生理学会大会
- Place of Presentation
  浜松
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-16K01922
[Presentation] 小腸内分泌L細胞におけるリソフォスファチジルイノシトール依存性細胞内Ca2+濃度上昇機構2016
- Author(s)
  原田一貴, 北口哲也, 神谷泰智，坪井貴司
- Organizer
  第93回日本生理学会大会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-03-22
- Data Source
  KAKENHI-PROJECT-26460289
[Presentation] 赤色蛍光タンパク質を用いた生体内cAMP可視化プローブの開発2016
- Author(s)
  伊藤幹、原田一貴、Devina Wongso、坪井貴司、北口哲也
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K01922
[Presentation] 蛍光タンパク質を用いた単色型cGMP可視化プローブの開発2016
- Author(s)
  松田翔吾、原田一貴、伊藤幹、滝澤舞、Devina Wongso、坪井貴司、北口哲也
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K01922
[Presentation] 蛍光タンパク質を用いた単色型cGMP可視化プローブの開発2016
- Author(s)
  松田翔吾, 原田一貴, 伊藤幹, 滝澤舞, Devina Wongso, 坪井貴司, 北口哲也
- Organizer
  第39回日本分子生物学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Data Source
  KAKENHI-PROJECT-26460289
[Presentation] 胃グレリン分泌細胞からのグレリン分泌制御機構の解析2016
- Author(s)
  原田一貴, 北口哲也, 大屋愛実, 沼野利佳, 佐藤貴弘, 児島将康，坪井貴司
- Organizer
  第93回日本生理学会大会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-03-23
- Invited
- Data Source
  KAKENHI-PROJECT-26460289
[Presentation] グルタミン酸によるインクレチン分泌制御機構の解析2016
- Author(s)
  阪口秀和, 原田一貴, 坪井貴司
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-26291018
[Presentation] 腸内細菌代謝産物によるインクレチン分泌制御機構の解析2016
- Author(s)
  佐田尚子, 原田一貴, 神谷泰智, 坪井貴司
- Organizer
  第39回日本分子生物学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-26291018
[Presentation] 小腸内分泌L細胞株におけるL-グルタミン投与時のGLP-1分泌機構2016
- Author(s)
  神谷泰智，原田一貴, 北口哲也, 坪井貴司
- Organizer
  第93回日本生理学会大会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-03-22
- Data Source
  KAKENHI-PROJECT-26460289
[Presentation] アストロサイトからのペプチドホルモン放出メカニズムの可視化解析2016
- Author(s)
  滝澤舞, 原田一貴, 坪井貴司
- Organizer
  第39回日本分子生物学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-26291018
[Presentation] RGBカラーの蛍光ATPセンサーが切り拓くエネルギー代謝研究2016
- Author(s)
  新井敏、伊藤寿朗、坪井貴司、北口哲也
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-25350970
[Presentation] リゾリン脂質によるグルカゴン様ペプチド-1分泌制御機構2016
- Author(s)
  原田一貴, 北口哲也, 神谷泰智, 太田邦史, 坪井貴司
- Organizer
  第39回日本分子生物学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-26291018
[Presentation] グルタミン依存性グルカゴン様ペプチド-1分泌機構の解析2016
- Author(s)
  神谷泰智, 原田一貴, 坪井貴司
- Organizer
  第39回日本分子生物学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-26291018
[Presentation] アドレナリンによるインクレチン分泌調節機構の解析2015
- Author(s)
  原田一貴、北口哲也、坪井貴司
- Organizer
  第92回日本生理学会大会
- Place of Presentation
  神戸国際会議場展示場（兵庫県神戸市）
- Year and Date
  2015-03-22
- Data Source
  KAKENHI-PROJECT-26460289
[Presentation] 小胞型ヌクレオチドトランスポーターによるリソソームを介したATP分泌制御機構の解析2014
- Author(s)
  坪井貴司、大屋愛実、北口哲也
- Organizer
  第９１回日本生理学会大会
- Place of Presentation
  鹿児島大学郡元キャンパス　（鹿児島県鹿児島市）
- Data Source
  KAKENHI-PROJECT-24790207
[Presentation] 小胞型ヌクレオチドトランスポーターによるリソソームを介したATP分泌制御機構の解析2014
- Author(s)
  坪井貴司、大屋愛実、北口哲也
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島大学郡元キャンパス、鹿児島県鹿児島市
- Year and Date
  2014-03-17
- Data Source
  KAKENHI-PROJECT-24790207
[Presentation] Vesicular nucleotide transporter regulates ATP storage in secretory lysosome in astrocyte.2014
- Author(s)
  Takashi Tsuboi, Manami Oya and Tetsuya Kitaguchi.
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-25350970
[Presentation] アドレナリンによる小腸内分泌L細胞からのGLP-1分泌への影響2014
- Author(s)
  原田一貴、北口哲也、坪井貴司
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-25
- Data Source
  KAKENHI-PROJECT-26460289
[Presentation] 小腸内分泌細胞GLUTag細胞におけるグルタミン依存性GLP-1分泌機構の解明2013
- Author(s)
  大屋愛実、坪井貴司
- Organizer
  第90回日本生理学会
- Place of Presentation
  タワーホール船堀（東京）
- Data Source
  KAKENHI-PROJECT-24790207
[Presentation] 小腸内分泌細胞および膵β細胞機能のライブイメージング解析2013
- Author(s)
  坪井貴司
- Organizer
  第118回日本解剖学会総会
- Place of Presentation
  サンポートホール高松・かがわ国際会議場、香川県高松市
- Year and Date
  2013-03-29
- Data Source
  KAKENHI-PROJECT-24790207
[Presentation] アミノ酸依存性グルカゴン様ペプチド-1ホルモン分泌メカニズムの解析2013
- Author(s)
  大屋愛実、北口哲也、坪井貴司
- Organizer
  第36回日本神経科学大会
- Place of Presentation
  国立京都国際会館、京都府京都市
- Year and Date
  2013-06-20
- Data Source
  KAKENHI-PROJECT-24790207
[Presentation] 小腸内分泌細胞および膵β細胞機能のライブイメージング解析2013
- Author(s)
  坪井貴司
- Organizer
  第118回日本解剖学会総会
- Place of Presentation
  サンポートホール高松・かがわ国際会議場（高松）
- Invited
- Data Source
  KAKENHI-PROJECT-24790207
[Presentation] Development of intensiometric fluorescent indicators for sensing the dynamics of intracellular ATP.2013
- Author(s)
  Satoshi Arai, Manami Oya, Takashi Tsuboi and Tetsuya Kitaguchi.
- Organizer
  第36回分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25350970
[Presentation] Elucidation of amino acid-induced GLP-1 secretion from enteroendocrine L cells2012
- Author(s)
  大屋愛実、北口哲也、坪井貴司
- Organizer
  第35回日本分子生物学会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡（福岡）
- Data Source
  KAKENHI-PROJECT-24790207
[Presentation] ホルモン分泌制御メカニズムの可視化解析2012
- Author(s)
  坪井貴司
- Organizer
  第83回動物学会
- Place of Presentation
  大阪大学豊中キャンパス（大阪）
- Invited
- Data Source
  KAKENHI-PROJECT-24790207
[Presentation] Visualization of cAMP dynamics and exocytosis in insulin-secreting MIN6 cells2012
- Author(s)
  北口哲也、大屋愛実、和田祥子、坪井貴司、宮脇敦史
- Organizer
  第35回日本分子生物学会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡（福岡）
- Data Source
  KAKENHI-PROJECT-24790207
[Presentation] 産生時間依存的な開口放出制御機構の解析2011
- Author(s)
  坪井貴司、北口哲也、唐澤智司、福田光則、宮脇敦史
- Organizer
  第88回日本生理学会
- Place of Presentation
  横浜(パシフィコ横浜会議センター)
- Year and Date
  2011-03-28
- Data Source
  KAKENHI-PROJECT-21790197
[Presentation] 産生時間依存的な開口放出制御機構の解析2011
- Author(s)
  坪井貴司、北口哲也、唐澤智司、福田光則、宮脇敦史
- Organizer
  第88回日本生理学会
- Place of Presentation
  横浜
- Year and Date
  2011-03-28
- Data Source
  KAKENHI-PROJECT-21790197
[Presentation] 海馬神経細胞におけるAMPAが誘導する核内Ca2+上昇と核内顆粒出現に対するIP3 signalingの解析2010
- Author(s)
  茨木京子、山本清二、坪井貴司、寺川進
- Organizer
  第33回日本神経科学大会
- Place of Presentation
  神戸(神戸コンベンションセンター)
- Year and Date
  2010-09-03
- Data Source
  KAKENHI-PROJECT-21790197
[Presentation] ミオシン2は表層繊維状アクチンの再編成を介して融合孔の開いている時間を制御する2010
- Author(s)
  青木亮、北口哲也、宮脇敦史、坪井貴司
- Organizer
  第87回日本生理学会
- Place of Presentation
  盛岡
- Year and Date
  2010-05-20
- Data Source
  KAKENHI-PROJECT-21790197
[Presentation] 産生時間依存的な開口放出制御機構の解析2010
- Author(s)
  坪井貴司、北口哲也、唐澤智司、福田光則、宮脇敦史
- Organizer
  第87回日本生理学会
- Place of Presentation
  盛岡
- Year and Date
  2010-05-20
- Data Source
  KAKENHI-PROJECT-21790197
[Presentation] オシン2は表層繊維状アクチンの再編成を介して融合孔の開いている時間を制御する2010
- Author(s)
  青木亮、北口哲也、宮脇敦史、坪井貴司
- Organizer
  第87回日本生理学会
- Place of Presentation
  盛岡(盛岡市民文化ホール)
- Year and Date
  2010-05-20
- Data Source
  KAKENHI-PROJECT-21790197
[Presentation] 蛍光プローブを用いた膵β細胞におけるグルタミン酸誘導性インスリン分泌の可視化解析2010
- Author(s)
  大屋愛実、佐藤舞、鈴木秀幸、佐藤守俊、坪井貴司
- Organizer
  第87回日本生理学会
- Place of Presentation
  盛岡(盛岡市民文化ホール)
- Year and Date
  2010-05-20
- Data Source
  KAKENHI-PROJECT-21790197
[Presentation] Model Guided Quantification of Exocytotic Vesicle Dynamics.2010
- Author(s)
  Lee SJ, Oh S, Huang C, Watanabe H, Tsuboi T.
- Organizer
  50th American Society for Cell Biology
- Place of Presentation
  Philadelphia, PA
- Year and Date
  2010-12-12
- Data Source
  KAKENHI-PROJECT-21790197
[Presentation] 海馬神経細胞におけるAMPAが誘導する核内Ca2+上昇と核内穎粒出現に対するIP3 signalingの解析2010
- Author(s)
  茨木京子、山本清二、坪井貴司、寺川進
- Organizer
  第33回日本神経科学大会
- Place of Presentation
  神戸
- Year and Date
  2010-09-03
- Data Source
  KAKENHI-PROJECT-21790197
[Presentation] 産生時間依存的な開口放出制御機構の解析2010
- Author(s)
  坪井貴司、北口哲也、唐澤智司、福田光則、宮脇敦史
- Organizer
  第87回日本生理学会
- Place of Presentation
  盛岡(盛岡市民文化ホール)
- Year and Date
  2010-05-20
- Data Source
  KAKENHI-PROJECT-21790197
[Presentation] Model Guided Quantification of Exocytotic Vesicle Dynamics2010
- Author(s)
  Lee SJ, Oh S, Huang C, Watanabe H, Tsuboi T
- Organizer
  50th American Society for Cell Biology
- Place of Presentation
  Philadelphia, PA, USA (Pennsylvania Convention Center)
- Year and Date
  2010-12-12
- Data Source
  KAKENHI-PROJECT-21790197
[Presentation] 蛍光プローブを用いた膵β細胞におけるグルタミン酸誘導性インスリン分泌の可視化解析2010
- Author(s)
  大屋愛実、佐藤舞、鈴木秀幸、佐藤守俊、坪井貴司
- Organizer
  第87回日本生理学会
- Place of Presentation
  盛岡
- Year and Date
  2010-05-20
- Data Source
  KAKENHI-PROJECT-21790197
[Presentation] Myosin II regulates "kiss-and-run" dense-core exocytosis revealed by total internal reflection fluorescence microscopy.2009
- Author(s)
  Aoki R, Kitaguchi T, Tsuboi T.
- Organizer
  XXXVI International Congress of Physiological Sciences
- Place of Presentation
  京都
- Year and Date
  2009-07-28
- Data Source
  KAKENHI-PROJECT-21790197
[Presentation] Actin filament functions as an exocytosis promoting factor in neuroendocrine cells2009
- Author(s)
  佐藤舞、坪井貴司
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-21790197
[Presentation] Glucose-induced IP3 signal in pancreatic MIN6 cells revealed by GFP-based FRET probe2009
- Author(s)
  大屋愛実、鈴木秀幸、佐藤守俊、坪井貴司
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-21790197
[Presentation] Monocarboxylate transporter-2(MCT2)regulates subcellular localization and surface expression of glutamate receptor-2 (GluR2)2009
- Author(s)
  前川文彦, 坪井貴司, 矢田俊彦, Luc Pellerin
- Organizer
  XXXVI International Congress of Physiological Sciences
- Place of Presentation
  京都
- Year and Date
  2009-07-27
- Data Source
  KAKENHI-PROJECT-21790197
[Presentation] 乳酸輸送体MCT2がグルタミン酸AMPA受容体サブタイプGluR2の細胞膜表面発現に及ぼす影響2009
- Author(s)
  前川文彦, 坪井貴司, 矢田俊彦, Luc Pellerin.
- Organizer
  第52回日本糖尿病学会
- Place of Presentation
  大阪
- Year and Date
  2009-05-21
- Data Source
  KAKENHI-PROJECT-21790197
[Presentation] Myosin II regulates "kiss-and-run" dense-core exocytosis revealed by total internal reflection fluorescence microscopy2009
- Author(s)
  Aoki R, Kitaguchi T, Tsuboi T
- Organizer
  XXXVI International Congress of Physiological Sciences
- Place of Presentation
  京都
- Year and Date
  2009-07-27
- Data Source
  KAKENHI-PROJECT-21790197
[Presentation] Automated kinetic characterization of exocytotic events in total internal reflection microscopy2009
- Author(s)
  Lee JSJ, Huang CC, Kenyon Z, Watanabe H, Tsuboi T.
- Organizer
  49th American Society for Cell Biology
- Place of Presentation
  San Diego, CA, USA
- Year and Date
  2009-12-06
- Data Source
  KAKENHI-PROJECT-21790197
[Presentation] Myosin II modulates a size of exocytotic fusion pore in neuroendocrine cells2009
- Author(s)
  Aoki R, Kitaguchi T, Miyawaki A, Tsuboi T
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋
- Year and Date
  2009-09-16
- Data Source
  KAKENHI-PROJECT-21790197
[Presentation] Different peptide hormone release dynamics on astrocytes2009
- Author(s)
  柳原優、坪井貴司
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-21790197
[Presentation] Monocarboxylate transporter-2 (MCT2) regulates subcellular localization and surface expression of glutamate receptor-2 (GluR2).2009
- Author(s)
  Maekawa F, Tsuboi T, Yada T, Pellerin L.
- Organizer
  XXXVI International Congress of Physiological Sciences
- Place of Presentation
  京都
- Year and Date
  2009-07-29
- Data Source
  KAKENHI-PROJECT-21790197
[Presentation] Myosin II modulates a size of exocytotic fusion pore in neuroendocrine cells2009
- Author(s)
  Aoki R, Kitaguchi T, Miyawaki A, Tsuboi T.
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋
- Year and Date
  2009-09-16
- Data Source
  KAKENHI-PROJECT-21790197
[Presentation] マクロファージ由来サイトカイン分泌機構の解析2009
- Author(s)
  森亮一、池松和哉、下川功、坪井貴司
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-21790197
[Presentation] 全反射蛍光顕微鏡を用いた開口放出反応の可視化解析2008
- Author(s)
  坪井貴司
- Organizer
  文部科学省特定領域研究「植物メリステム」代表者町田泰則、NAIST植物科学研究教育推進事業
- Place of Presentation
  奈良
- Year and Date
  2008-11-21
- Data Source
  KAKENHI-PROJECT-18689008
[Presentation] 細胞表面可視化法によるホルモン分泌メカニズムの解明2008
- Author(s)
  坪井貴司
- Organizer
  東京大学ナノバイオ・インテグレーション研究拠点成果発表会
- Place of Presentation
  東京大学(東京)
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-18689008
[Presentation] Rabphilinによるホルモン分泌顆粒ドッキング制御機構の可視化解析2008
- Author(s)
  坪井貴司
- Organizer
  日本生理学会
- Place of Presentation
  東京
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-18689008
[Presentation] 全反射蛍光顕微鏡を用いた開口放出反応の可視化解析2008
- Author(s)
  坪井貴司
- Organizer
  「視る生物学3 -イメージングの挑戦-」文部科学省特定領域研究「植物メリステム」班会議
- Place of Presentation
  奈良先端科学技術大学院大学(奈良)
- Year and Date
  2008-11-21
- Data Source
  KAKENHI-PROJECT-18689008
[Presentation] Rabphilin によるホルモン分泌顆粒ドッキング制御機構の可視化解析2008
- Author(s)
  坪井貴司
- Organizer
  第85回日本生理学会大会
- Place of Presentation
  東京
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-18689008
[Presentation] 細胞表面可視化法によるホルモン分泌メカニズムの解明2008
- Author(s)
  坪井貴司
- Organizer
  東京大学ナノバイオ・インテグレーション研究拠点成果発表会
- Place of Presentation
  東京
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-18689008
[Presentation] Rab エフェクタータンパク質によるホルモン分泌制御機構の可視化解析2008
- Author(s)
  坪井貴司
- Organizer
  第81回日本内分泌学会学術総会
- Place of Presentation
  青森
- Year and Date
  2008-05-17
- Data Source
  KAKENHI-PROJECT-18689008
[Presentation] Rabエフェクタータンパク質によるホルモン分泌制御機構の可視化解析2008
- Author(s)
  坪井貴司
- Organizer
  日本内分泌学会学術総会
- Place of Presentation
  青森
- Year and Date
  2008-05-17
- Data Source
  KAKENHI-PROJECT-18689008
[Presentation] シナプトタグミン7による調節性分泌制御機構の可視化解析2007
- Author(s)
  坪井貴司, 福田光則
- Organizer
  第30回日本神経科学学会大会
- Place of Presentation
  横浜
- Year and Date
  2007-09-11
- Data Source
  KAKENHI-PROJECT-18689008
[Presentation] シナプトタグミン7による調節性分泌制御機構の可視化解析2007
- Author(s)
  坪井貴司他1名
- Organizer
  日本神経科学学会
- Place of Presentation
  横浜
- Year and Date
  2007-09-11
- Data Source
  KAKENHI-PROJECT-18689008
[Presentation] Live cell imagingによるホルモン分泌顆粒ドッキング機構の解析2007
- Author(s)
  坪井貴司
- Organizer
  先進治療学セミナー(順天堂大学医学部先進糖尿病治療学)
- Place of Presentation
  東京
- Year and Date
  2007-06-18
- Data Source
  KAKENHI-PROJECT-18689008
[Presentation] Live cell imagingによるホルモン分泌顆粒ドッキング機構の解析2007
- Author(s)
  坪井貴司
- Organizer
  第3回先進治療学セミナー順天堂大学医学部先進糖尿病治療学・内科代謝内分泌学セミナー
- Place of Presentation
  順天堂大学医学部(東京)
- Year and Date
  2007-06-18
- Data Source
  KAKENHI-PROJECT-18689008
[Presentation] Live cell imagingによるホルモン分泌顆粒輸送分子機構の解析2007
- Author(s)
  坪井貴司
- Organizer
  東京大学大学院医学系研究科疾患生命工学センター若手研究者セミナー
- Place of Presentation
  東京大学(東京)
- Year and Date
  2007-06-12
- Data Source
  KAKENHI-PROJECT-18689008
[Presentation] カテコールアミン産生腫瘍細胞を用いたホルモン分泌制御機構の可視化解析2007
- Author(s)
  坪井貴司
- Organizer
  日本組織細胞化学会総会、日本臨床分子形態学会総会
- Place of Presentation
  甲府
- Year and Date
  2007-09-28
- Data Source
  KAKENHI-PROJECT-18689008
[Presentation] Recruitment, docking, and fusion of hormone vesicles distinctively revealed by total internal reflection fluorescence microscopy in live neuroendocrine cells2007
- Author(s)
  坪井貴司
- Organizer
  理化学研究所フロンティア研究システム研究成果発表会
- Place of Presentation
  和光
- Year and Date
  2007-05-18
- Data Source
  KAKENHI-PROJECT-18689008
[Presentation] カテコールアミン産生腫瘍細胞を用いたホルモン分泌制御機構の可視化解析2007
- Author(s)
  坪井貴司
- Organizer
  第48回日本組織細胞化学会総会、第39回日本臨床分子形態学会総会
- Place of Presentation
  甲府
- Year and Date
  2007-09-28
- Data Source
  KAKENHI-PROJECT-18689008
[Presentation] Recruitment, docking, and fusion of hormone vesicles distinctively revealed by total internal reflection fluorescence microscopy in live neuroendocrine cells2007
- Author(s)
  坪井貴司
- Organizer
  第2回理化学研究所フロンティア研究システム研究成果発表会
- Place of Presentation
  理化学研究所(和光)
- Year and Date
  2007-05-18
- Data Source
  KAKENHI-PROJECT-18689008
[Presentation] ホルモン分泌顆粒ドッキング機構の分子メカニズムの解明2007
- Author(s)
  坪井貴司
- Organizer
  日本生理学会
- Place of Presentation
  大阪
- Year and Date
  2007-03-20
- Data Source
  KAKENHI-PROJECT-18689008
[Presentation] ホルモン分泌顆粒ドッキング機構の分子メカニズムの解明2007
- Author(s)
  坪井貴司
- Organizer
  第87回日本生理学会大会
- Place of Presentation
  大阪
- Year and Date
  2007-03-20
- Data Source
  KAKENHI-PROJECT-18689008
[Presentation] Live cell imagingによるホルモン分泌顆粒輸送分子機構の解析2007
- Author(s)
  坪井貴司
- Organizer
  東京大学大学院医学系研究か疾患生命工学センター若手研究者セミナー
- Place of Presentation
  東京
- Year and Date
  2007-06-12
- Data Source
  KAKENHI-PROJECT-18689008
[Presentation] Rab3AとRab27Aによるホルモン分泌顆粒ドッキング制御機構の可視化解析2006
- Author(s)
  坪井貴司, 福田光則
- Organizer
  第29回日本神経科学会大会
- Place of Presentation
  京都
- Year and Date
  2006-07-21
- Data Source
  KAKENHI-PROJECT-18689008
[Presentation] Role of Slp family proteins in regulated exocytosis in neuroendocrine cells2006
- Author(s)
  Tsuboi T, Fukuda M
- Organizer
  20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
- Place of Presentation
  京都
- Year and Date
  2006-06-20
- Data Source
  KAKENHI-PROJECT-18689008
[Presentation] ホルモン顆粒輸送分子機構の生細胞イメージング解析2006
- Author(s)
  坪井貴司, 福田光則
- Organizer
  日本下垂体研究会第21回学術集会
- Place of Presentation
  静岡
- Year and Date
  2006-08-02
- Data Source
  KAKENHI-PROJECT-18689008
[]
[]

1. KITAGUCHI TETSUYA (60432374)

# of Collaborated Projects: 7 results

# of Collaborated Products: 32 results
2. IKEMATSU Kazuya (80332857)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. 原田一貴 (60830734)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
4. Ohta Kunihiro (90211789)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. Matsumoto Mitsuharu (50505972)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 山本琢磨 (50634458)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 梅原敬弘 (60617421)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. TSURUYA Shinitirou (90562108)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. NAKASONO Ichirou (30108287)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. NAKAHARA Aya (80719005)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Suo Satoshi (20596845)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. 阿部俊太郎 (80335116)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 新井敏 (70454056)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
14. 上田宏 (60232758)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
15. 掛山正心 (30353535)

# of Collaborated Projects: 1 results

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16. 朱博 (70886605)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 鈴木団 (40350475)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 原口省吾 (20592132)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. スルチョードリビシュワジット (00535453)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 佐竹炎 (20280688)

# of Collaborated Projects: 1 results

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21. 石川紘司 (40794946)

# of Collaborated Projects: 1 results

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22. 斉木臣二 (00339996)

# of Collaborated Projects: 1 results

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23. 栗原新 (20630966)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 日暮琢磨 (90622580)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 末次憲之 (60514156)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 三田真理恵

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 岡本仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 中村和昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tsuboi Takashi 坪井 貴司

TSUBOI Takashi 坪井 貴司

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腸内細菌代謝物による認知的柔軟性制御における消化管ホルモンを介した分子機構の解析Principal Investigator

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ホルモン分泌における環状ヌクレオチドシグナリングを照らすキナーゼ光スイッチ開発Principal Investigator

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Elucidation of chemical communication between microbiota and enteroendocrine cellsPrincipal Investigator

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Elucidation of the metabolic regulation mechanism of neuronsPrincipal Investigator

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Regulation of incretin secretion by microbiota metabolitesPrincipal Investigator

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Microbial regulation of hormone secretion from enteroendocrinePrincipal Investigator

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Molecular mechanisms of gastrointestinal hormone secretion by intestinal bacterial metabolitesPrincipal Investigator

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Tsuboi Takashi 坪井貴司

TSUBOI Takashi 坪井貴司