Yuyama Kohei 湯山耕平

… Alternative Names

湯山耕平ユヤマコウヘイ

YUYAMA Kohei 湯山耕平

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Researcher Number	80415546
Other IDs
External Links
Affiliation (Current)	2025: 北海道大学, 産学・地域協働推進機構, 特任准教授 2025: 北海道大学, 先端生命科学研究院, 特任准教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 北海道大学, 先端生命科学研究院, 特任准教授 2018 – 2020: 北海道大学, 先端生命科学研究院, 特任准教授 2016: 北海道大学, 先端生命科学研究院, 特任准教授 2015: 北海道大学, 先端生命科学研究科(研究院), 特任准教授 2014: 北海道大学, 先端生命科学研究科(研究院), 特任助教 … More 2012: 北海道大学, 大学院・先端生命科学研究院, 特任助教 2011 – 2012: 北海道大学, 先端生命科学研究科(研究院), 特任助教 2010: Hokkaido University, 大学院・先端生命科学研究院, 特任助教 2009: National Institute for Longevity Sciences,NCGG, アルツハイマー病研究部, 特任研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 46010:Neuroscience-general-related / Functional biochemistry / Neurochemistry/Neuropharmacology / Structural biochemistry
Keywords	Principal Investigator エクソソーム / アルツハイマー病 / アミロイドbeta / 細胞外小胞 / デジタル検出 / 神経細胞 / Abeta / 糖鎖 / ニューロン / ミクログリア … More / スフィンゴ糖脂質 / 中枢神経系 / ガングリオシド / 糖質 Less

デジタル測定による脳内アミロイドβ蓄積とアミロイドβ結合エクソソーム量の相関解析Principal Investigator
- Principal Investigator
  
  湯山耕平
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Hokkaido University
The mechnisms of physiological exosome delivery to neuronsPrincipal Investigator
- Principal Investigator
  
  Yuyama Kohei
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  Hokkaido University
Exosome-like synthetic liposomes containing glycosphingolipids for therapy of Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  Yuyama Kohei
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hokkaido University
Clearance of neuronal exosomes in brain平成25年5月20日現在Principal Investigator
- Principal Investigator
  
  YUYAMA Kohei
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Hokkaido University
Effect of exosome-associated gangliosides on the assembly of amyloid-β proteinPrincipal Investigator
- Principal Investigator
  
  YUYAMA Kohei
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Hokkaido University
  National Institute for Longevity Sciences,NCGG

All 2023 2022 2020 2019 2018 2017 2016 2015 2014 2012 2011 2010 2009 Other

All Journal Article Presentation Patent

[Journal Article] Stereochemistry‐activity relationship of ceramide‐induced exosome production to clear amyloid‐β in Alzheimer's disease2023
- Author(s)
  Abdelrasoul Mariam、Yuyama Kohei、Swamy Mahadeva M. M.、Murai Yuta、Monde Kenji
- Journal Title
  
  Chirality
  
  Volume: 35 Issue: 9 Pages: 577-585
- DOI
  10.1002/chir.23568
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07341, KAKENHI-PROJECT-21K05303
[Journal Article] Extracellular vesicle proteome unveils cathepsin B connection to Alzheimer’s disease pathogenesis2023
- Author(s)
  Yuyama Kohei、Sun Hui、Fujii Risa、Hemmi Isao、Ueda Koji、Igeta Yukifusa
- Journal Title
  
  Brain
  
  Volume: 147 Issue: 2 Pages: 627-636
- DOI
  10.1093/brain/awad361
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07341
[Journal Article] Immuno-digital invasive cleavage assay for analyzing Alzheimer’s amyloid beta-bound extracellular vesicles2022
- Author(s)
  Yuyama Kohei、Sun Hui、Igarashi Yasuyuki、Monde Kenji、Hirase Takumi、Nakayama Masato、Makino Yoichi
- Journal Title
  
  Alzheimer's Research and Therapy
  
  Volume: 14 Issue: 1 Pages: 140-140
- DOI
  10.1186/s13195-022-01073-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07341, KAKENHI-PROJECT-19H02836
[Journal Article] Glucocerebrosidases catalyze a transgalactosylation reaction that yields a newly-identified brain sterol metabolite, galactosylated cholesterol2020
- Author(s)
  Akiyama, H., Ide, M., Nagatsuka, Y., Sayano, T., Nakanishi, E., Uemura, N., Yuyama, K., Yamaguchi, Y., Kamiguchi, H., Takahashi, R., Aerts, J. M. F. G., Greimel, P. and Hirabayashi, Y
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 295 Issue: 16 Pages: 5257-5277
- DOI
  10.1074/jbc.ra119.012502
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KK0147, KAKENHI-PROJECT-16K14687, KAKENHI-PROJECT-17K15608, KAKENHI-PROJECT-18K06456, KAKENHI-PROJECT-18H04041, KAKENHI-PROJECT-16H06290, KAKENHI-PROJECT-19H03362
[Journal Article] Lysosomal‐associated transmembrane protein 4B regulates ceramide‐induced exosome release2020
- Author(s)
  Yuyama Kohei、Sun Hui、Mikami Daisuke、Mioka Tetsuo、Mukai Katsuyuki、Igarashi Yasuyuki
- Journal Title
  
  The FASEB Journal
  
  Volume: 34 Issue: 12 Pages: 16022-16033
- DOI
  10.1096/fj.202001599r
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06456
[Journal Article] Nrp1 is Activated by Konjac Ceramide Binding-Induced Structural Rigidification of the a1a2 Domain2020
- Author(s)
  Usuki Seigo、Yasutake Yoshiaki、Tamura Noriko、Tamura Tomohiro、Tanji Kunikazu、Saitoh Takashi、Murai Yuta、Mikami Daisuke、Yuyama Kohei、Monde Kenji、Mukai Katsuyuki、Igarashi Yasuyuki
- Journal Title
  
  Cells
  
  Volume: 9 Issue: 2 Pages: 517-517
- DOI
  10.3390/cells9020517
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06456, KAKENHI-PUBLICLY-20H04756, KAKENHI-PROJECT-19H02836
[Journal Article] Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice2019
- Author(s)
  Othman Muhamad Aqmal、Yuyama Kohei、Murai Yuta、Igarashi Yasuyuki、Mikami Daisuke、Sivasothy Yasodha、Awang Khalijah、Monde Kenji
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 10 Issue: 8 Pages: 1154-1158
- DOI
  10.1021/acsmedchemlett.9b00171
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06456, KAKENHI-PROJECT-19H02836, KAKENHI-PROJECT-17K19188
[Journal Article] Plant sphingolipids promote extracellular vesicle release and alleviate amyloid-β pathologies in a mouse model of Alzheimer’s disease2019
- Author(s)
  Yuyama Kohei、Takahashi Kaori、Usuki Seigo、Mikami Daisuke、Sun Hui、Hanamatsu Hisatoshi、Furukawa Junichi、Mukai Katsuyuki、Igarashi Yasuyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 16827-16827
- DOI
  10.1038/s41598-019-53394-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06456
[Journal Article] Extracellular Vesicles from Amnion-Derived Mesenchymal Stem Cells Ameliorate Hepatic Inflammation and Fibrosis in Rats2018
- Author(s)
  Ohara Masatsugu、Ohnishi Shunsuke、Hosono Hidetaka、Yamamoto Koji、Yuyama Kohei、Nakamura Hideki、Fu Qingjie、Maehara Osamu、Suda Goki、Sakamoto Naoya
- Journal Title
  
  Stem Cells International
  
  Volume: 2018 Pages: 1-15
- DOI
  10.1155/2018/3212643
- NAID
  120006585982
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06456, KAKENHI-PROJECT-16H05282, KAKENHI-PROJECT-17J00434, KAKENHI-PROJECT-16K09334
[Journal Article] Multiple roles of SMS2 in white and brown adipose tissues form diet-induced obese mice2018
- Author(s)
  H. Hamamatsu, S. Mitsutake, S. Sakai, T. Okazaki, K. Watanabe, Y. Igarashi, K. Yuyama
- Journal Title
  
  J. Metabolic Syndrome
  
  Volume: 7 Issue: 02 Pages: 241-241
- DOI
  10.4172/2167-0943.1000241
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07794, KAKENHI-PROJECT-18K06456
[Journal Article] Konjac Ceramide (kCer) Regulates NGF-Induced Neurite Outgrowth via the Sema3A Signaling Pathway2018
- Author(s)
  Usuki Seigo、Tamura Noriko、Yuyama Kohei、Tamura Tomohiro、Mukai Katsuyuki、Igarashi Yasuyuki
- Journal Title
  
  J. Oleo Sci.
  
  Volume: 67 Issue: 1 Pages: 77-86
- DOI
  10.5650/jos.ess17141
- NAID
  130006301047
- ISSN
  1345-8957, 1347-3352
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06456
[Journal Article] Exosomes as Carriers of Alzheimer's Amyloid-beta2017
- Author(s)
  Yuyama K., Igarashi Y.
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 印刷中
- DOI
  10.3389/fnins.2017.00229
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26440041
[Journal Article] Physiological and Pathological Roles of Exosomes in the Nervous System2016
- Author(s)
  Yuyama K., Igarashi Y.
- Journal Title
  
  Biomolecular Concepts
  
  Volume: 7 Issue: 1 Pages: 53-68
- DOI
  10.1515/bmc-2015-0033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26440041
[Journal Article] A potential function for neuronal exosomes: sequestering intracerebral amyloid-β peptide.2015
- Author(s)
  Yuyama K., Sun H., Usuki S., Sakai S., Hanamatsu H., Mioka T., Kimura N., Okada M., Tahara H., Furukawa J., Fujitani N., Shinohara Y., and Igarashi Y.
- Journal Title
  
  FEBS letters
  
  Volume: 589 Pages: 84-88
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26440041
[Journal Article] Decreased amyloid-beta pathologies by intracerebral loading of glycosphingolipid-enriched exosomes in Alzheimer model mice.2014
- Author(s)
  Yuyama, K., Sun, H., Sakai, S., Mitsutake, S., Okada, M., Tahara, H., Furukawa, J., Fujitani, N., Shinohara, Y. & Igarashi, Y.
- Journal Title
  
  J Biol Chem
  
  Volume: 289 Issue: 35 Pages: 24488-24498
- DOI
  10.1074/jbc.m114.577213
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-25112711, KAKENHI-PROJECT-26290047, KAKENHI-PROJECT-26310106, KAKENHI-PROJECT-26440041, KAKENHI-PROJECT-26450162, KAKENHI-PROJECT-26640091, KAKENHI-PROJECT-221S0001
[Journal Article] Sphingolipid-modulated exosome secretion promotes the clearance of amyloid-ß by microglia2012
- Author(s)
  Yuyama, K, Sun H, Mitsutake S, Igarashi Y.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 287 Pages: 10977-10989
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700435
[Journal Article] Sphingolipid-modulatedexosome secretion promotes clearance ofamyloid-β by microglia2012
- Author(s)
  Yuyama K., Sun H., Mitsutake S., andIgarashi Y.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 287(14) Pages: 10977-89
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700435
[Journal Article] Ganglioside GD3 monoclonal antibody-induced paxillin tyrosine phosphorylation and filamentous actin assembly in cerebellar growth cones.2011
- Author(s)
  Yuyama K., Sekino-Suzuki N, Yamamoto N, Kasahara K.
- Journal Title
  
  J.Neurochem. 116
  
  Pages: 845-850
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770128
[Journal Article] Ganglioside GD3 monoclonal antibody-induced paxillin tyrosine phosphorylation and filamentous actin assembly in cerebellar growth cones2011
- Author(s)
  Yuyama K., Sekino-Suzuki N, Yamamoto N, Kasahara K.
- Journal Title
  
  J.Neurochem.
  
  Volume: 116 Pages: 845-850
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770128
[Journal Article] Sphingomyelin accumulation provides a favorable milieu for GM1 ganglioside-induced assembly of amyloid beta-protein2010
- Author(s)
  Yuyama K., Yanagisawa K.
- Journal Title
  
  Neurosci.Lett.
  
  Volume: 481 Pages: 168-172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770128
[Journal Article] Sphingomyelin accumulation provides a favorable milieu for GM1 ganglioside-induced assembly of amyloid β-protein.2010
- Author(s)
  Yuyama K., Yanagisawa K.
- Journal Title
  
  Neurosci.Lett. 481
  
  Pages: 168-172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770128
[Journal Article] アルツハイマー病におけるエンドサイトーシス障害2009
- Author(s)
  湯山耕平, 柳澤勝彦
- Journal Title
  
  Dementia Japan 23
  
  Pages: 47-54
- Data Source
  KAKENHI-PROJECT-21770128
[Patent] アミロイド s 関連疾患用の医薬とそのスクリーニング技術2011
- Inventor(s)
  湯山耕平、五十嵐靖之、光武進、吉田哲也
- Industrial Property Rights Holder
  北海道大学、塩野義製薬(株)
- Filing Date
  2011-10-14
- Overseas
- Data Source
  KAKENHI-PROJECT-23700435
[Presentation] アルツハイマー病診断を目指したデジタルICAを用いた細胞外小胞検出法開発2022
- Author(s)
  湯山耕平, 孫慧, 五十嵐靖之, 平瀬匠, 中山雅人, 牧野洋一
- Organizer
  第41回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07341
[Presentation] アミロイドbeta結合型糖脂質GM1含有細胞外小胞のデジタル検出法開発2022
- Author(s)
  湯山耕平, 孫慧, 五十嵐靖之, 平瀬匠, 中山雅人, 牧野洋一
- Organizer
  第9回日本細胞外小胞学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07341
[Presentation] Dietary ceramides in skin and brain health2019
- Author(s)
  Kohei Yuyama
- Organizer
  7th International Conference on Food Factors (ICoFF2019)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06456
[Presentation] こんにゃくセラミドによるエクソソームを介した脳内アミロイドbetaの除去メカニズム2019
- Author(s)
  湯山耕平
- Organizer
  第73回日本栄養・食糧学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06456
[Presentation] セラミドによるエクソソーム産生誘導とその神経疾患関連機能2019
- Author(s)
  湯山耕平
- Organizer
  第12回セラミド研究会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06456
[Presentation] アルツハイマー病予防・治療のためのエクソソーム機能利用2017
- Author(s)
  湯山耕平
- Organizer
  第16回日本再生医療学会総会
- Place of Presentation
  仙台国際センター (宮城県仙台市)
- Year and Date
  2017-03-08
- Data Source
  KAKENHI-PROJECT-26440041
[Presentation] アルツハイマー病予防のためのスフィンゴ脂質含有細胞外ベシクル2016
- Author(s)
  湯山耕平
- Organizer
  第９回セラミド研究会学術集会
- Place of Presentation
  東京ユビキタス協創広場CANVAS (東京都中央区)
- Year and Date
  2016-10-27
- Invited
- Data Source
  KAKENHI-PROJECT-26440041
[Presentation] 神経細胞由来エクソソームのアミロイドbetaクリアランス効果2015
- Author(s)
  湯山耕平, 孫慧, 五十嵐靖之
- Organizer
  日本認知症学会学術集会
- Place of Presentation
  リンクステーションホール青森(青森県青森市)
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-26440041
[Presentation] セラミド代謝依存性エクソソーム分泌がアミロイドß蛋白質分解に与える影響2012
- Author(s)
  湯山耕平
- Organizer
  第５回セラミド研究会学術集会
- Place of Presentation
  ユビキタス協創広場CANVAS(東京都)
- Data Source
  KAKENHI-PROJECT-23700435
[Presentation] セラミド代謝依存性エクソソーム分泌がアミロイド s 蛋白質分解に与える影響2012
- Author(s)
  湯山耕平,孫慧,光武進,五十嵐靖之
- Organizer
  第5回セラミド研究会学術集会
- Place of Presentation
  ユビキタス協創広場CANVAS, 東京
- Year and Date
  2012-10-11
- Data Source
  KAKENHI-PROJECT-23700435
[Presentation] Sphingolipid-modulated exosome release supports clearance of Alzheimer's amyloid2012
- Author(s)
  KoheiYuyama , Hui Sun, Susumu Mitsutake, Yasuyuki Igarashi
- Organizer
  The 10th International Symposium for Future Drug Discovery and Medical Care
- Place of Presentation
  Hokkaido University, Sapporo, Hokkaido, Japan
- Year and Date
  2012-10-02
- Data Source
  KAKENHI-PROJECT-23700435
[Presentation] 神経細胞endocytosis障害による GM1 ガングリオシド誘導性アミロイドs蛋白質重合の促進2011
- Author(s)
  湯山耕平、柳澤勝彦
- Organizer
  第29回日本認知症学会
- Place of Presentation
  ウインク愛知・愛知県名古屋
- Year and Date
  2011-10-06
- Data Source
  KAKENHI-PROJECT-23700435
[Presentation] Sphingolipid metabolism modulates exosomerelease from neurons: Its involvement indegradation of Alzheimer's amyloid2011
- Author(s)
  Kohei Yuyama, Yasuyuki Igarashi
- Organizer
  The9th International Symposium for FutureDrug Discovery and Medical Care
- Place of Presentation
  Hokkaido University, Sapporo,Hokkaido, Japan
- Year and Date
  2011-09-29
- Data Source
  KAKENHI-PROJECT-23700435
[Presentation] 神経細胞endocytosis障害によるGM1ガングリオシド誘導性アミロイドβ蛋白質重合の促進2010
- Author(s)
  湯山耕平
- Organizer
  第29回日本認知症学会
- Place of Presentation
  愛知県名古屋、ウインク愛知
- Data Source
  KAKENHI-PROJECT-21770128
[Presentation] Endocytic pathway perturbation as a putative cause of GM1-ganglioside-induced amyloid fibril formation in Alzheimer's disease.2010
- Author(s)
  Kohei Yuyama
- Organizer
  The 27th Naito Conference on Membrane Dynamics and Lipid Biology [I]
- Place of Presentation
  Sapporo, Hokkaido, Japan
- Data Source
  KAKENHI-PROJECT-21770128
[Presentation] エンドサイトーシス障害によるGM1ガングリオシド蓄積とアミロイドβ白質の重合促進2010
- Author(s)
  湯山耕平
- Organizer
  第5回スフィンゴテラピー研究会
- Place of Presentation
  鳥取県米子、米子市観光センター
- Data Source
  KAKENHI-PROJECT-21770128
[Presentation] Involvement of sphingomyelin in the generation of an endogenous seed for Alzheimer amyloid, Gaβ2010
- Author(s)
  Kohei Yuyama
- Organizer
  第53回日本神経化学会
- Place of Presentation
  兵庫県神戸、神戸コンベンションセンター
- Data Source
  KAKENHI-PROJECT-21770128
[Presentation] アルツハイマー病におけるGM1ガングリオシド誘導アミロイドβ蛋白質重合に関与する後期エンドサイトーシス障害2009
- Author(s)
  湯山耕平
- Organizer
  第52回日本神経化学会
- Place of Presentation
  群馬県渋川市、ホテル天坊
- Year and Date
  2009-06-22
- Data Source
  KAKENHI-PROJECT-21770128
[Presentation] エンドサイトーシス障害時におけるGM1ガングリオシド依存性アミロイド蛋白質重合2009
- Author(s)
  湯山耕平、柳澤勝彦
- Organizer
  日本糖質学会
- Place of Presentation
  岐阜県高山市
- Year and Date
  2009-09-09
- Data Source
  KAKENHI-PROJECT-21770128
[Presentation] エンドサイトーシス障害におけるGM1ガングリオシド依存性アミロイドβ蛋白質重合2009
- Author(s)
  湯山耕平
- Organizer
  第29回日本糖質学会年会
- Place of Presentation
  岐阜県高山市、飛騨・世界生活文化センター
- Data Source
  KAKENHI-PROJECT-21770128
[Presentation] 神経細胞由来エクソソームのアミロイドbeta蛋白質除去効果
- Author(s)
  湯山耕平, 孫慧, 五十嵐靖之
- Organizer
  第１回日本細胞外顆粒学会
- Place of Presentation
  グランドプリンスホテル広島（広島県広島市）
- Year and Date
  2014-08-28 – 2014-08-30
- Data Source
  KAKENHI-PROJECT-26440041
[Presentation] アミロイドbeta蛋白質代謝におけるスフィンゴ糖脂質含有細胞外顆粒エクソソームの役割
- Author(s)
  湯山耕平、孫慧、古川潤一、篠原康郎、五十嵐靖之
- Organizer
  第33回日本糖質学会
- Place of Presentation
  名古屋大学（愛知県名古屋市）
- Year and Date
  2014-08-10 – 2014-08-12
- Invited
- Data Source
  KAKENHI-PROJECT-26440041
[Presentation] 神経細胞由来エクソソームはミクログリアによるアミロイドbetaの取り込みを促進する
- Author(s)
  湯山耕平, 孫慧, 光武進, 五十嵐靖之
- Organizer
  第30回日本認知症学会学術集会
- Place of Presentation
  タワーホール船堀(東京都)
- Data Source
  KAKENHI-PROJECT-23700435

1. 光武進

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 秋山央子

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# of Collaborated Products: 1 results
3. 田原栄俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yuyama Kohei 湯山 耕平

湯山 耕平 ユヤマ コウヘイ

YUYAMA Kohei 湯山 耕平

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デジタル測定による脳内アミロイドβ蓄積とアミロイドβ結合エクソソーム量の相関解析Principal Investigator

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The mechnisms of physiological exosome delivery to neuronsPrincipal Investigator

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Exosome-like synthetic liposomes containing glycosphingolipids for therapy of Alzheimer's diseasePrincipal Investigator

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Clearance of neuronal exosomes in brain平成25年5月20日現在Principal Investigator

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Effect of exosome-associated gangliosides on the assembly of amyloid-β proteinPrincipal Investigator

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[Journal Article] Stereochemistry‐activity relationship of ceramide‐induced exosome production to clear amyloid‐β in Alzheimer's disease2023

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[Journal Article] Extracellular vesicle proteome unveils cathepsin B connection to Alzheimer’s disease pathogenesis2023

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[Journal Article] Immuno-digital invasive cleavage assay for analyzing Alzheimer’s amyloid beta-bound extracellular vesicles2022

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[Journal Article] Glucocerebrosidases catalyze a transgalactosylation reaction that yields a newly-identified brain sterol metabolite, galactosylated cholesterol2020

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[Journal Article] Lysosomal‐associated transmembrane protein 4B regulates ceramide‐induced exosome release2020

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[Journal Article] Nrp1 is Activated by Konjac Ceramide Binding-Induced Structural Rigidification of the a1a2 Domain2020

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[Journal Article] Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice2019

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[Journal Article] Plant sphingolipids promote extracellular vesicle release and alleviate amyloid-β pathologies in a mouse model of Alzheimer’s disease2019

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[Journal Article] Extracellular Vesicles from Amnion-Derived Mesenchymal Stem Cells Ameliorate Hepatic Inflammation and Fibrosis in Rats2018

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Yuyama Kohei 湯山耕平

湯山耕平ユヤマコウヘイ

YUYAMA Kohei 湯山耕平

[Patent] アミロイド s 関連疾患用の医薬とそのスクリーニング技術2011