Motono Chie 本野千恵

… Alternative Names

本野千恵モトノチエ

MOTONO Chie 本野千恵

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Researcher Number	80415752
Affiliation (Current)	2026: 国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員
Affiliation (based on the past Project Information) *help	2021 – 2024: 国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員 2017: 産業技術総合研究所, 創薬分子プロファイリング研究センター, 主任研究員
Review Section/Research Field	Principal Investigator Basic Section 62010:Life, health and medical informatics-related Except Principal Investigator Basic Section 62010:Life, health and medical informatics-related / Structural biochemistry
Keywords	Principal Investigator 分子動力学シミュレーション / 進化 / 残基間コンタクト / タンパク質 / アロステリック効果 Except Principal Investigator アロステリック制御 / クリプトサイト / タンパク質構造 / 疾患関連変異分布 / 共溶媒分子動力学計算 … More / タンパク質機能推定 / アロステリックサイト / 共溶媒分子動力学シミュレーション / AlphaFold / クリプティックサイト / タンパク質機能予測 / 疾患関連変異 / モデリング / NMR / ホモロジーモデリング / ＮＭＲ / 自動解析 / データベース / 核磁気共鳴法 Less

アミノ酸残基間コンタクトで見るアロステリック効果のメカニズムと進化Principal Investigator
- Principal Investigator
  
  本野千恵
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 62010:Life, health and medical informatics-related
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Identification of potential functional sites through spatial clustering of disease-associated missense variants in protein structures
- Principal Investigator
  
  Kenichiro Imai
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 62010:Life, health and medical informatics-related
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Development of NMR drug discovery pipeline using database
- Principal Investigator
  
  Kobayashi Naohiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka University

All 2025 2024 2023 2015

All Journal Article Presentation

[Journal Article] CrypToth: Cryptic pocket detection through mixed-solvent molecular dynamics simulations based topological data analysis2025
- Author(s)
  Koseki J, Motono C, Yanagisawa K, Kudo G, Yoshino R, Hirokawa T, Imai K
- Journal Title
  
  J. Chem. Inf. Model
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H03551
[Journal Article] The origin of esterase activity of Parkinson's disease causative factor DJ-1 implied by evolutionary trace analysis of its prokaryotic homolog HchA2024
- Author(s)
  Watanabe A, Koyano F, Imai K, Hizukuri Y, Ogiwara S, Ito T, Miyamoto J, Shibuya C, Kimura M, Toriumi K, Motono C, Arai M, Tanaka K, Akiyama Y, Yamano K, Matsuda N.
- Journal Title
  
  J Biol Chem.
  
  Volume: 300(7) Issue: 7 Pages: 107476-107476
- DOI
  10.1016/j.jbc.2024.107476
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H03551, KAKENHI-PLANNED-23H04923, KAKENHI-PROJECT-23H05474, KAKENHI-PROJECT-22K07609, KAKENHI-PROJECT-23K23835, KAKENHI-PROJECT-23K23841, KAKENHI-PROJECT-23K27535
[Journal Article] Atg15 is a vacuolar phospholipase that disintegrates organelle membranes2023
- Author(s)
  Watanabe Yasunori、Iwasaki Yurina、Sasaki Kyoka、Motono Chie、Imai Kenichiro、Suzuki Kuninori
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 12 Pages: 113567-113567
- DOI
  10.1016/j.celrep.2023.113567
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06096, KAKENHI-PROJECT-21K19205, KAKENHI-PROJECT-21H03551, KAKENHI-PROJECT-23K23833
[Presentation] 疾患関連変異のタンパク質構造上の三次元分布に基づく新規クリプティックサイト探索2024
- Author(s)
  本野千恵　鍵和田晴美　小関準　土方敦司　今井賢一郎
- Organizer
  第47回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K11313
[Presentation] Development of the Cryptic Site searching method with Mixed-solvent molecular dynamics and Topological data analyses methods2024
- Author(s)
  Jun Koseki, Chie Motono, Keisuke Yanagiswa, Genki Kudo, Ryunosuke Yoshino, Takatsugu Hirokawa, Kenichiro Imai
- Organizer
  CBI学会2024年大会
- Data Source
  KAKENHI-PROJECT-21H03551
[Presentation] 疾患関連変異のタンパク質構造上の三次元分布に基づく新規クリプティックサイト探索2024
- Author(s)
  本野千恵、鍵和田晴美、小関準、土方敦司、今井賢一郎
- Organizer
  第47回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21H03551
[Presentation] Cryptic site prediction using mixed-solvent molecular dynamics simulation,2024
- Author(s)
  本野千恵, 柳澤渓甫, 工藤玄己, 広川貴次, 今井賢一郎
- Organizer
  第24回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-21H03551
[Presentation] 共溶媒分子動力学シミュレーションによるクリプティックサイト予測2024
- Author(s)
  本野千恵　小関準　柳澤渓甫　工藤玄己　広川貴次　今井賢一郎
- Organizer
  第24回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-23K11313
[Presentation] Cryptic site detection using machine learning based on mixed-solvent molecular dynamics simulations results2024
- Author(s)
  Chie Motono, Jun Koseki, Keisuke Yanagisawa, Genki Kudo, Ryunosuke Yoshino, Takatsugu Hirokawa, Kenichiro Imai
- Organizer
  1st Asia & Pacific Bioinformatics Joint Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03551
[Presentation] Development of the Cryptic Site searching method with Mixed-solvent molecular dynamics and Topological data analyses methods2024
- Author(s)
  Jun Koseki, Chie Motono, Keisuke Yanagisawa, Genki Kudo, Ryunosuke Yoshino, Takatsugu Hirokawa, Kenichiro Imai
- Organizer
  1st Asia & Pacific Bioinformatics Joint Conference
- Data Source
  KAKENHI-PROJECT-21H03551
[Presentation] A search method for novel protein functional site based on the spatial distribution of disease-associated missense variants2023
- Author(s)
  本野千恵、土方敦司、広川貴次、今井賢一郎
- Organizer
  CBI学会2023年大会
- Data Source
  KAKENHI-PROJECT-21H03551
[Presentation] Search for novel protein functional sites based on the spatial distribution of disease-associated missense variants2023
- Author(s)
  Chie Motono, Atsushi Hijikata, Takatsugu Hirokawa,　Kenichiro Imai
- Organizer
  8th Autumn School of Chemoinformatics in Nara
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K11313
[Presentation] A search method for novel protein functional site based on the spatial distribution of disease-associated missense variants2023
- Author(s)
  本野千恵、土方敦司、広川貴次、今井賢一郎
- Organizer
  8th Autumn School of Chemoinformatics in Nara
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03551
[Presentation] Searchfor novel protein functional sites based on the spatial distribution of disease-associated missense variants2023
- Author(s)
  本野千恵、土方敦司、広川貴次、今井賢一郎
- Organizer
  第51回構造活性相関シンポジウム
- Data Source
  KAKENHI-PROJECT-21H03551
[Presentation] NMRデータベースBioMagResBankの統合的拡張と公開2015
- Author(s)
  小林直宏、横地政史、岩田武史、本野千恵、廣明秀一、児嶋長次郎、藤原敏道
- Organizer
  第54回NMR討論会
- Place of Presentation
  千葉工業大学, 千葉県習志野市
- Year and Date
  2015-11-06
- Data Source
  KAKENHI-PROJECT-15K06970

1. Kobayashi Naohiro (80272160)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. HIROAKI Hidekazu (10336589)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. Kenichiro Imai (80442573)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
4. 児嶋長次郎 (50333563)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 土方敦司 (80415273)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. 足達俊吾 (90783803)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 渡邊康紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Motono Chie 本野 千恵

本野 千恵 モトノ チエ

MOTONO Chie 本野 千恵

Research Projects

Research Products

Co-Researchers

アミノ酸残基間コンタクトで見るアロステリック効果のメカニズムと進化Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of potential functional sites through spatial clustering of disease-associated missense variants in protein structures

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of NMR drug discovery pipeline using database

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] CrypToth: Cryptic pocket detection through mixed-solvent molecular dynamics simulations based topological data analysis2025

Author(s)

Journal Title

Data Source

[Journal Article] The origin of esterase activity of Parkinson's disease causative factor DJ-1 implied by evolutionary trace analysis of its prokaryotic homolog HchA2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Atg15 is a vacuolar phospholipase that disintegrates organelle membranes2023

Author(s)

Journal Title

DOI

Data Source

[Presentation] 疾患関連変異のタンパク質構造上の三次元分布に基づく新規クリプティックサイト探索2024

Author(s)

Organizer

Data Source

[Presentation] Development of the Cryptic Site searching method with Mixed-solvent molecular dynamics and Topological data analyses methods2024

Author(s)

Organizer

Data Source

[Presentation] 疾患関連変異のタンパク質構造上の三次元分布に基づく新規クリプティックサイト探索2024

Author(s)

Organizer

Data Source

[Presentation] Cryptic site prediction using mixed-solvent molecular dynamics simulation,2024

Author(s)

Organizer

Data Source

[Presentation] 共溶媒分子動力学シミュレーションによるクリプティックサイト予測2024

Author(s)

Organizer

Data Source

[Presentation] Cryptic site detection using machine learning based on mixed-solvent molecular dynamics simulations results2024

Author(s)

Organizer

Data Source

[Presentation] Development of the Cryptic Site searching method with Mixed-solvent molecular dynamics and Topological data analyses methods2024

Author(s)

Organizer

Data Source

[Presentation] A search method for novel protein functional site based on the spatial distribution of disease-associated missense variants2023

Author(s)

Organizer

Data Source

[Presentation] Search for novel protein functional sites based on the spatial distribution of disease-associated missense variants2023

Author(s)

Organizer

Data Source

[Presentation] A search method for novel protein functional site based on the spatial distribution of disease-associated missense variants2023

Author(s)

Organizer

Data Source

[Presentation] Searchfor novel protein functional sites based on the spatial distribution of disease-associated missense variants2023

Author(s)

Motono Chie 本野千恵

本野千恵モトノチエ

MOTONO Chie 本野千恵