Tanaka Naoki 田中直樹

… Alternative Names

TANAKA Naoki 田中直樹

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Researcher Number	80419374
Other IDs	https://orcid.org/0000-0002-3212-3836
Affiliation (Current)	2025: 信州大学, 学術研究院医学系, 教授
Affiliation (based on the past Project Information) *help	2025: 信州大学, 学術研究院医学系, 教授 2020 – 2023: 信州大学, 学術研究院医学系, 教授 2015 – 2019: 信州大学, 学術研究院医学系, 准教授 2017: 信州大学, 医学(系)研究科(研究院), 准教授 2010: Shinshu University, 医学(系)研究科(研究院), 助教 2007 – 2009: Shinshu University, 医学系研究科, 助教
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 49010:Pathological biochemistry-related / Experimental pathology Except Principal Investigator Basic Section 53040:Nephrology-related / Pathological medical chemistry / Basic Section 59040:Nutrition science and health science-related / General medical chemistry
Keywords	Principal Investigator 栄養学 / 肝臓病学 / 病理学 / 機能性食品 / メタボローム解析 / 腸内細菌 / β-catenin / 脂肪肝炎 / 肝線維化 / c-Myc … More / βカテニン / 小胞体ストレス / 肝癌 / トランス脂肪酸 / 食事中脂質 / 脂質 / 疾患モデル動物 / 腸管・肝臓連関 / マイクロアレイ解析 / CD44 / コレステロール毒性 / メタボロミクス / 核内受容体 / 非アルコール性脂肪肝炎 / 肝細胞癌 / 脂肪肝 / C型肝炎ウイルス / アルコール / 内科 / ストレス … More Except Principal Investigator PPARα / スルファチド / 酸化ストレス / 脂肪酸代謝 / 炎症 / 全身臓器 / 腎 / 不飽和脂肪酸 / 虚血再灌流 / 飢餓 / autophagy / 腎臓病 / 老化促進モデルマウス / 硫酸化糖脂質 / 老化 / C型肝炎 / 発癌 / 脂質 / 肝臓非癌部・癌部 / トランス脂肪酸食 / デオキシコール酸 / PPARalpha / C型肝炎ウイルスコア蛋白 / 肝がん / トランス脂肪酸 / HCV / 生体分子 / ケモカイン / 野生型マウス / 胃粘膜 / リアルタイムPCR / PPAR / 肝炎 / エタノール / NF-κB / NF-kB / 肝障害 / レシチン / アルコール Less

腎のPPARα機能・脂肪酸代謝の低下が腎臓病と全身臓器に及ぼす影響の解析
- Principal Investigator
  
  上條祐司
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Shinshu University
Analyses of the effects of autophagy-fatty acid metabolism crosstalk on kidney dysfunction
- Principal Investigator
  
  上條祐司
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Shinshu University
The study on novel brain aging mechanisms related to brain-specific lipids and development of preventive methods
- Principal Investigator
  
  中嶌岳郎
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Shinshu University
Elucidating the impact of dietary trans fatty acids on hepatocarcinogenesis and developing stategies for preventing hepatocarcinogenesisPrincipal Investigator
- Principal Investigator
  
  Tanaka Naoki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Shinshu University
Elucidation of mechanism on hepatitis C-related liver cancer exacerbation by trans-fatty acid toxicity and development of preventive method
- Principal Investigator
  
  AOYAMA Toshifumi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Shinshu University
Evaluating the pathogenesis of non-alcoholic steatohepatitis from the viewpoint of xenobiotic metabolismPrincipal Investigator
- Principal Investigator
  
  TANAKA Naoki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Shinshu University
Studies on a novel oxidative stress-reducing effect resulting from generation/excretion of sulfated glycolipids
- Principal Investigator
  
  Nakajima Takero
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Shinshu University
PPARα活性化抑制を標的としたC型肝炎関連肝癌の予防法の開発Principal Investigator
- Principal Investigator
  
  田中直樹
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Shinshu University
Elucidation of molecular mechanisms for alcohol-dependent inflammatory disorders in digestive tract and liver and development of their preventive methods
- Principal Investigator
  
  AOYAMA Toshifumi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Shinshu University
Analysis of pathogenesis of alcoholic liver disease and development of novel therapies using PPARalpha-null micePrincipal Investigator
- Principal Investigator
  
  TANAKA Naoki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Shinshu University

All 2023 2022 2021 2019 2017 2016 2009 Other

All Journal Article Presentation

[Journal Article] Establishment of Novel Mouse Model of Dietary NASH Rapidly Progressing into Liver Cirrhosis and Tumors.2023
- Author(s)
  Zheng Q, Kawaguchi M, Mikami H, Diao P, Zhang X, Zhang Z, Nakajima T, Iwadare T, Kimura T, Nakayama J, and Tanaka N
- Journal Title
  
  Cancers
  
  Volume: 15 Issue: 14 Pages: 3744-3744
- DOI
  10.3390/cancers15143744
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K11618
[Journal Article] 多機能性分子・硫酸化糖脂質の機能と制御2023
- Author(s)
  中嶌岳郎、田中直樹
- Journal Title
  
  信州医学雑誌
  
  Volume: 71 Pages: 137-147
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K11618
[Journal Article] Serum sulfatide level is associated with severe systemic vasculitis with kidney involvement.2023
- Author(s)
  Aomura D, Harada M, Nakajima T, Nimura T, Yamaka K, Yamada Y, Hashimoto K, Tanaka N, Kamijo Y
- Journal Title
  
  Front. Immunol.
  
  Volume: 14 Pages: 1271741-1271741
- DOI
  10.3389/fimmu.2023.1271741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K11618
[Journal Article] Serum Sulfatide Levels as a Biomarker of Active Glomerular Lesion in Patients with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: A Single Center Pilot Study2022
- Author(s)
  Harada Makoto、Nakajima Takero、Yamada Yosuke、Aomura Daiki、Yamaguchi Akinori、Sonoda Kosuke、Tanaka Naoki、Hashimoto Koji、Kamijo Yuji
- Journal Title
  
  Journal of Clinical Medicine
  
  Volume: 11 Issue: 3 Pages: 762-762
- DOI
  10.3390/jcm11030762
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17736, KAKENHI-PROJECT-18K08204, KAKENHI-PROJECT-21K11618
[Journal Article] Clinically Relevant Dose of Pemafibrate, a Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator (SPPARMα), Lowers Serum Triglyceride Levels by Targeting Hepatic PPARα in Mice2022
- Author(s)
  Zhang Zhe、Diao Pan、Zhang Xuguang、Nakajima Takero、Kimura Takefumi、Tanaka Naoki
- Journal Title
  
  Biomedicines
  
  Volume: 10 Issue: 7 Pages: 1667-1667
- DOI
  10.3390/biomedicines10071667
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K11618
[Journal Article] Acidic activated charcoal prevents obesity and insulin resistance in high-fat diet-fed mice.2022
- Author(s)
  Zhang X, Diao P, Yokoyama H, Inoue Y, Tanabe K, Wang X, Hayashi C, Yokoyama T, Zhang Z, Hu X, Nakajima T, Kimura T, Nakayama J, Nakamuta M, and Tanaka N.
- Journal Title
  
  Front. Nutr.
  
  Volume: 9 Pages: 852767-852767
- DOI
  10.3389/fnut.2022.852767
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K11618
[Journal Article] Impact of Dietary Fat on the Progression of Liver Fibrosis: Lessons from Animal and Cell Studies2021
- Author(s)
  Jia Fangping、Hu Xiao、Kimura Takefumi、Tanaka Naoki
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 19 Pages: 10303-10303
- DOI
  10.3390/ijms221910303
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07383
[Journal Article] Mechanisms of Steatosis-Derived Hepatocarcinogenesis: Lessons from HCV Core Gene Transgenic Mice.2021
- Author(s)
  Diao P, Jia F, Wang X, Hua X, Kimura T, Nakajima T, Aoyama T, Moriya K, Koike K, Tanaka N.
- Journal Title
  
  Engineering
  
  Volume: 7 Issue: 12 Pages: 1797-1805
- DOI
  10.1016/j.eng.2021.08.019
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K11618
[Journal Article] Pemafibrate Protects against Fatty Acid-Induced Nephropathy by Maintaining Renal Fatty Acid Metabolism2021
- Author(s)
  Aomura Daiki、Harada Makoto、Yamada Yosuke、Nakajima Takero、Hashimoto Koji、Tanaka Naoki、Kamijo Yuji
- Journal Title
  
  Metabolites
  
  Volume: 11 Issue: 6 Pages: 372-372
- DOI
  10.3390/metabo11060372
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17736, KAKENHI-PROJECT-21K11618
[Journal Article] A high-cholesterol diet promotes steatohepatitis and liver tumorigenesis in HCV core gene transgenic mice.2019
- Author(s)
  Wang X, Tanaka N, Hu X, Kimura T, Lu Y, Jia F, Sato Y, Nakayama J, Moriya K, Koike K, Aoyama T
- Journal Title
  
  Arch Toxicol.
  
  Volume: in press Issue: 6 Pages: 1713-1725
- DOI
  10.1007/s00204-019-02440-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08616
[Journal Article] Decreased Fatty Acid <i>β</i>-Oxidation Is the Main Cause of Fatty Liver Induced by Polyunsaturated Fatty Acid Deficiency in Mice2017
- Author(s)
  Nakajima T, Yang Y, Lu Y, Kamijo Y, Yamada Y, Nakamura K, Koyama M, Yamaguchi S, Sugiyama E, Tanaka N, Aoyama T
- Journal Title
  
  Tohoku J. Exp. Med.
  
  Volume: 242 Issue: 3 Pages: 229-239
- DOI
  10.1620/tjem.242.229
- NAID
  130005808367
- ISSN
  0040-8727, 1349-3329
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08264
[Journal Article] Age-dependent PPARα activation induces hepatic sulfatide accumulation in transgenic mice carrying the hepatitis C virus core gene.2016
- Author(s)
  Tian Y, Yang Y, Zhang X, Nakajima T, Tanaka N, Sugiyama E, Kamijo Y, Lu Y, Moriya K, Koike K, Gonzalez FJ, Aoyama T.
- Journal Title
  
  Glycoconj J
  
  Volume: 33 Issue: 6 Pages: 927-936
- DOI
  10.1007/s10719-016-9703-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08264, KAKENHI-PROJECT-16K08616
[Journal Article] Activation of PPARα by Fatty Acid Accumulation Enhances Fatty Acid Degradation and Sulfatide Synthesis.2016
- Author(s)
  Yang Y, Feng Y, Zhang X, Nakajima T, Tanaka N, Sugiyama E, Kamijo Y, Aoyama T.
- Journal Title
  
  Tohoku J Exp Med
  
  Volume: 240 Issue: 2 Pages: 113-22
- DOI
  10.1620/tjem.240.113
- NAID
  130005245903
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08264
[Journal Article] Polyenephosphatidylcholine prevents alcoholic liver disease in PPARa-null mice through attenuation of increases in oxidative stress
- Author(s)
  Okiyama W, Tanaka N, Nakajima T, Tanaka E, Kiyosawa K, Gonzalez F J, Aoyama T
- Journal Title
  
  J Hepatol
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590301
[Presentation] Polyenephosphatidylcholine prevents alcoholic liver disease in PPARalpha-null mice through attenuation of increases in oxidative stress2009
- Author(s)
  Tanaka N, Okiyama Y, Aoyama T
- Organizer
  19^<th> Conference of the Asian Pacific Association for the Study of the Liver
- Place of Presentation
  Hong Kong
- Year and Date
  2009-02-14
- Data Source
  KAKENHI-PROJECT-19790476
[Presentation] アルコール性肝炎に対するポリエンフォスファチジルコリンの有用性2009
- Author(s)
  田中直樹, 小松通治, 青山俊文
- Organizer
  第12回日本病態栄養学会学術集会
- Place of Presentation
  京都
- Year and Date
  2009-01-11
- Data Source
  KAKENHI-PROJECT-19790476
[Presentation] Polyenephosphatidylcholine prevents alcoholic liver disease in PPARalpha-null mice through attenuation of increases in oxida tive stress2009
- Author(s)
  Tanaka N, Okiyama W, Aoyama T
- Organizer
  19^<th> conference of the Asian Pacific Association for the Study of the Liver
- Place of Presentation
  Hong Kong
- Year and Date
  2009-02-14
- Data Source
  KAKENHI-PROJECT-19590301
[Presentation] Polyenephosphatidylcholine prevents alcoholic liver disease in PPARalpha-null mice through attenuation of increases in oxidative stress2009
- Author(s)
  Tanaka N, Okiyama W, Aoyama T
- Organizer
  19^<th> conference of the Asian Pacific Association for the Study of the Liver
- Place of Presentation
  The People's Republic of China
- Year and Date
  2009-02-14
- Data Source
  KAKENHI-PROJECT-19790476

1. AOYAMA Toshifumi (50231105)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
2. Nakajima Takero (30581011)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
3. KAMIJO Yuji (50377636)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
4. NAKAMURA Kozo (20345763)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 長屋匡信 (00718033)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 菅野祐幸 (40252663)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Gonzalez Frank j

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TAKAHASHI Shogo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 山田洋輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Tanaka Naoki 田中 直樹

TANAKA Naoki 田中 直樹

Research Projects

Research Products

Co-Researchers

腎のPPARα機能・脂肪酸代謝の低下が腎臓病と全身臓器に及ぼす影響の解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analyses of the effects of autophagy-fatty acid metabolism crosstalk on kidney dysfunction

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The study on novel brain aging mechanisms related to brain-specific lipids and development of preventive methods

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating the impact of dietary trans fatty acids on hepatocarcinogenesis and developing stategies for preventing hepatocarcinogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of mechanism on hepatitis C-related liver cancer exacerbation by trans-fatty acid toxicity and development of preventive method

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evaluating the pathogenesis of non-alcoholic steatohepatitis from the viewpoint of xenobiotic metabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on a novel oxidative stress-reducing effect resulting from generation/excretion of sulfated glycolipids

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

PPARα活性化抑制を標的としたC型肝炎関連肝癌の予防法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of molecular mechanisms for alcohol-dependent inflammatory disorders in digestive tract and liver and development of their preventive methods

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of pathogenesis of alcoholic liver disease and development of novel therapies using PPARalpha-null micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Establishment of Novel Mouse Model of Dietary NASH Rapidly Progressing into Liver Cirrhosis and Tumors.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 多機能性分子・硫酸化糖脂質の機能と制御2023

Author(s)

Journal Title

Data Source

[Journal Article] Serum sulfatide level is associated with severe systemic vasculitis with kidney involvement.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Serum Sulfatide Levels as a Biomarker of Active Glomerular Lesion in Patients with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: A Single Center Pilot Study2022

Tanaka Naoki 田中直樹

TANAKA Naoki 田中直樹