ISHIKAWA Shinji 石川晋之

Researcher Number	80419639
Other IDs
Affiliation (based on the past Project Information) *help	2021: 熊本大学, 大学院生命科学研究部(医), 特定研究員 2019 – 2020: 熊本大学, 病院, 非常勤診療医師 2015 – 2018: 熊本大学, 医学部附属病院, 非常勤診療医師 2007 – 2013: Kumamoto University, 医学部附属病院, 非常勤診療医師
Review Section/Research Field	Principal Investigator Digestive surgery / Basic Section 55020:Digestive surgery-related
Keywords	Principal Investigator スタチン / 大腸癌 / HDAC5 / BRAF / K-ras / Akt/PKB / MEK/ERK / p27 / EZH2 / コレステロール合成経路 … More / SREBP2 / 膵癌 / バイオマーカー / 難治癌 / Wnt inhibitor / simvastatin / TGFβ経路 / Wnt経路 / EGFR経路 / スタチンバイオマーカー / 薬物療法 / Wnt阻害薬 / シンバスタチン / BRAF遺伝子変異 / KRAS遺伝子変異 / statin（スタチン） / Elk-1 / pAkt / pERK / 薬剤耐性 / 相乗効果 / 併用療法 / 消化器癌 / MC1568 / コレステロール / ORP5 / 分子標的治療 / シグナル伝達 / 癌 / 遺伝子 Less

Development of statin-based therapies for colorectal cancer along with biomarkersPrincipal Investigator
- Principal Investigator
  
  Ishikawa Shinji
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kumamoto University
Elucidation of anti-tumor effect mechanism of statin in colorectal cancer and development of new treatmentPrincipal Investigator
- Principal Investigator
  
  ISHIKAWA Shinji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kumamoto University
Clarification of the lipid metabolism concerning progression of gastrointestinal cancer, followed by developing new therapy.Principal Investigator
- Principal Investigator
  
  ISHIKAWA Shinji
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kumamoto University
The crosstalk between cholesterol synthesis pathway and TGF-beta in pancreatic cancerPrincipal Investigator
- Principal Investigator
  
  ISHIKAWA Shinji
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kumamoto University
Identify the mechanism of invasion and metastasis of pancreatic cancer and development of novel treatment starategy.Principal Investigator
- Principal Investigator
  
  ISHIKAWA Shinji
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kumamoto University

All 2022 2020 2019 2018 2014 2013 2010 2008 Other

All Journal Article Presentation

[Journal Article] Construction and validation of a simple scoring system for stage III colorectal cancer recurrence (SiS-SCORE). A case control study2019
- Author(s)
  Ishikawa Shinji、Sawayama Hiroshi、Matsuo Akinobu、Uchino Ryojin、Honda Shinobu、Hirota Masahiko、Baba Hideo
- Journal Title
  
  Japanese Journal of Clinical Oncology
  
  Volume: 49 Issue: 3 Pages: 238-244
- DOI
  10.1093/jjco/hyy192
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10544
[Journal Article] Construction and validation of a simple scoring system for stage III colorectal cancer recurrence (SiS-SCORE).2018
- Author(s)
  Shinji Ishikawa, Hiroshi Sawayama, Akinobu Matsuo, Ryojin Uchino, Shinobu Honda, Masahiko Hirota, Hideo Baba
- Journal Title
  
  Annals of Surgical Oncology
  
  Volume: 査読中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10544
[Journal Article] Statins inhibit tumor progression via an enhancer of zeste homolog 2-mediated epigenetic alteration in colorectal cancer.2014
- Author(s)
  S. Ishikawa, H. Hayashi, K. Kinoshita, M. Abe, H. Kuroki, R. Tokunaga, S. Tomiyasu, H. Tanaka, H. Sugita, T. Arita, Y. Yagi, M. Watanabe, M. Hirotaand　H. Baba
- Journal Title
  
  Internationa Journal of Cancer
  
  Volume: Epub ahead of print Issue: 11 Pages: 2528-36
- DOI
  10.1002/ijc.28672
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592016, KAKENHI-PROJECT-24591911, KAKENHI-PROJECT-25462062, KAKENHI-PROJECT-25670588
[Journal Article] The role of oxysterol binding protein-related protein 5 in pancreatic cancer2010
- Author(s)
  Ishikawa S, Nagai Y, Baba H, et al
- Journal Title
  
  Cancer Science
  
  Volume: 101 Pages: 898-905
- NAID
  10026590764
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591525
[Journal Article] The role of oxysterol bindingprotein related protein 5 inpancreatic cancer2010
- Author(s)
  Ishikawa S,Nagai Y, Masuda T, Nakamura T,Imamura Y,Takamori H,Hirota M, Funakosi A,Fukushima M,Baba H
- Journal Title
  
  Cancer Sci
  
  Volume: 101 Pages: 898-905
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591525
[Journal Article] The role of Oxyster ol binding protein related protein 5 in pancreatic cancer
- Author(s)
  Ishikawa S
- Journal Title
  
  Cancer Scie nce (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591594
[Presentation] シンバスタチンと Wnt 阻害剤の併用は、K-ras、 BRAF 変異大腸癌細胞に対して相乗的な抗腫瘍効果を示す2022
- Author(s)
  石川晋之、緒方陽子、馬場秀夫
- Organizer
  第122回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-19K09221
[Presentation] 補助化学療法が有効だった結腸癌high risk stage IIの条件（一般市中病院のデータ）2020
- Author(s)
  石川晋之、本田志延、廣田昌彦、蔵野良一、馬場秀夫
- Organizer
  第120回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-19K09221
[Presentation] 大腸癌high risk StageⅡを考え直す2018
- Author(s)
  石川晋之、松尾彰宣、内野良仁、本田志延、蔵野良一、廣田昌彦、馬場秀夫
- Organizer
  第73回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-16K10544
[Presentation] StageⅢ大腸癌根治術後再発予測簡易スコアリングシステム（Simple Scoring System for StageⅢ Colorectal cancer Recurrence : SiS-SCORE)の構築と評価2018
- Author(s)
  石川晋之、澤山　浩、松尾彰宣、内野良仁、本田志延、廣田昌彦、馬場秀夫
- Organizer
  第118回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-16K10544
[Presentation] StageⅢ大腸癌根治術後再発予測簡易スコアリングシステム（Simple Scoring System for StageⅢ Colorectal cancer Recurrence : SiS-SCORE)の構築と評価2018
- Author(s)
  石川晋之、澤山　浩、松尾彰章、内野良仁、本田志延、廣田昌彦、馬場秀夫
- Organizer
  第118回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-16K10544
[Presentation] 大腸癌術後補助療法としてのスタチンの導入2013
- Author(s)
  石川晋之
- Organizer
  第68回日本消化器外科学会総会
- Place of Presentation
  宮崎シーガイアコンベンションセンター
- Data Source
  KAKENHI-PROJECT-25462062
[Presentation] 大腸癌術後補助療法としてのスタチンの可能性とそのメカニズム2013
- Author(s)
  石川晋之
- Organizer
  第13回日本外科学会定期学術集会
- Place of Presentation
  マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-25462062
[Presentation] コレステロール合成経路とORP5:膵癌浸潤とスタチンの効果のメカニズム2008
- Author(s)
  石川晋之
- Organizer
  第63回日本消化器外科学会
- Place of Presentation
  札幌, ロイトン札幌・札幌プリンスホテル
- Year and Date
  2008-07-16
- Data Source
  KAKENHI-PROJECT-19591594
[Presentation] 脂質代謝関連遺伝子0RP5と膵臓癌浸潤との関係2008
- Author(s)
  石川晋之
- Organizer
  第108回日本外科学会
- Place of Presentation
  長崎
- Year and Date
  2008-05-15
- Data Source
  KAKENHI-PROJECT-19591594
[Presentation] コレステロール合成経路と0RP5 : 膵癌浸潤とスタチンの効果のメカニズム2008
- Author(s)
  石川晋之
- Organizer
  第63回日本消化器外科学会
- Place of Presentation
  札幌
- Year and Date
  2008-07-16
- Data Source
  KAKENHI-PROJECT-19591594
[Presentation] 脂質代謝関連遺伝子ORP5と膵臓癌浸潤との関係2008
- Author(s)
  石川晋之
- Organizer
  第108回日本外科学会
- Place of Presentation
  長崎, ベストウェスタンプレミアホテル長崎
- Year and Date
  2008-05-15
- Data Source
  KAKENHI-PROJECT-19591594

1. TAKAMORI Hiroshi (90363514)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. BABA Hideo (20240905)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. 徳永竜馬 (20594881)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 東孝暁 (70594878)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 宮本裕士 (80551259)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. HIROTA Masahiko (80284769)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. HORINO Kei (60452900)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. BEPPU Touru (70301372)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. WATANABE Masayuki (80254639)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 船越顕博 (80112340)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 林洋光 (80625773)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 日吉幸晴 (30573612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 清住雄希 (30827324)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 宮田辰徳 (80594887)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. OHUCHI Mayuko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. SUGITA Hiroki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ISHIKAWA Shinji 石川 晋之

Research Projects

Research Products

Co-Researchers

Development of statin-based therapies for colorectal cancer along with biomarkersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of anti-tumor effect mechanism of statin in colorectal cancer and development of new treatmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clarification of the lipid metabolism concerning progression of gastrointestinal cancer, followed by developing new therapy.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The crosstalk between cholesterol synthesis pathway and TGF-beta in pancreatic cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identify the mechanism of invasion and metastasis of pancreatic cancer and development of novel treatment starategy.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Construction and validation of a simple scoring system for stage III colorectal cancer recurrence (SiS-SCORE). A case control study2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Construction and validation of a simple scoring system for stage III colorectal cancer recurrence (SiS-SCORE).2018

Author(s)

Journal Title

Data Source

[Journal Article] Statins inhibit tumor progression via an enhancer of zeste homolog 2-mediated epigenetic alteration in colorectal cancer.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The role of oxysterol binding protein-related protein 5 in pancreatic cancer2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] The role of oxysterol bindingprotein related protein 5 inpancreatic cancer2010

Author(s)

Journal Title

Data Source

[Journal Article] The role of Oxyster ol binding protein related protein 5 in pancreatic cancer

Author(s)

Journal Title

Data Source

[Presentation] シンバスタチンと Wnt 阻害剤の併用は、K-ras、 BRAF 変異大腸癌細胞に対して相乗的な抗腫瘍 効果を示す2022

Author(s)

Organizer

Data Source

[Presentation] 補助化学療法が有効だった結腸癌high risk stage IIの条件（一般市中病院のデータ）2020

Author(s)

Organizer

Data Source

[Presentation] 大腸癌high risk StageⅡを考え直す2018

Author(s)

Organizer

Data Source

[Presentation] StageⅢ大腸癌根治術後再発予測簡易スコアリングシステム（Simple Scoring System for StageⅢ Colorectal cancer Recurrence : SiS-SCORE)の構築と評価2018

Author(s)

Organizer

Data Source

[Presentation] StageⅢ大腸癌根治術後再発予測簡易スコアリングシステム（Simple Scoring System for StageⅢ Colorectal cancer Recurrence : SiS-SCORE)の構築と評価2018

Author(s)

Organizer

ISHIKAWA Shinji 石川晋之

[Presentation] シンバスタチンと Wnt 阻害剤の併用は、K-ras、 BRAF 変異大腸癌細胞に対して相乗的な抗腫瘍効果を示す2022