Takano Naoharu 高野直治

… Alternative Names

高野直治タカノナオハル

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Researcher Number	80445410
Other IDs	https://orcid.org/0000-0003-3364-2731
Affiliation (Current)	2025: 東京医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2025: 東京医科大学, 医学部, 准教授 2022 – 2023: 東京医科大学, 医学部, 准教授 2017 – 2020: 東京医科大学, 医学部, 講師 2010 – 2011: 慶應義塾大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Tumor therapeutics / Basic Section 48030:Pharmacology-related / Cell biology Except Principal Investigator Basic Section 53030:Respiratory medicine-related / Basic Section 54010:Hematology and medical oncology-related
Keywords	Principal Investigator がん / オートファジー / マクロライド / 休眠 / 化学療法耐性 / 細胞骨格 / リソソーム / 糖代謝 / メチル化修飾 / 一酸化炭素 … More Except Principal Investigator … More がん転移 / 上皮間葉転換 / チロシンキナーゼ阻害薬 / CALR / CD44 / 原発性骨髄線維症 / calreticulin / JAK2V617F / 骨髄増殖性腫瘍 Less

Regulatory mechanisms of epithelial-mesenchymal transition and cancer metastasis by GAK, a cellular target of EGFR tyrosine kinase inhibitors
- Principal Investigator
  
  平本正樹
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Tokyo Medical University
がん細胞はどのようにオートファジーを用いて化学療法から生き残り再増殖するのかPrincipal Investigator
- Principal Investigator
  
  高野直治
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tokyo Medical University
骨髄増殖性腫瘍幹細胞におけるCD44を中心とする接着因子発現・機能の調節機構解明
- Principal Investigator
  
  後藤明彦
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Tokyo Medical University
Elucidation of autophagy Inhibitory mechanisms of azithromycin and its tumor inhibitory effect in the mice model for cancer therapy.Principal Investigator
- Principal Investigator
  
  Takano Naoharu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Tokyo Medical University
Establishment of cancer stem cell targeting therapy using autophagy inhibitory activity of macrolide antibioticsPrincipal Investigator
- Principal Investigator
  
  Takano Naoharu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Tokyo Medical University
一酸化炭素によるタンパク質メチル化修飾を介した糖代謝制御と細胞機能制御の解明Principal Investigator
- Principal Investigator
  
  高野直治
- Project Period (FY)
  2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  Keio University

All 2023 2022 2020 2019 2018 2017 2010

All Journal Article Presentation

[Journal Article] Azithromycin, a potent autophagy inhibitor for cancer therapy, perturbs cytoskeletal protein dynamics2023
- Author(s)
  Takano Naoharu、Hiramoto Masaki、Yamada Yumiko、Kokuba Hiroko、Tokuhisa Mayumi、Hino Hirotsugu、Miyazawa Keisuke
- Journal Title
  
  British Journal of Cancer
  
  Volume: - Issue: 10 Pages: 1838-1849
- DOI
  10.1038/s41416-023-02210-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07298, KAKENHI-PROJECT-21K07106
[Journal Article] Ricolinostat enhances adavosertib‑induced mitotic catastrophe in TP53‑mutated head and neck squamous cell carcinoma cells2022
- Author(s)
  Miyake K, Takano N, Kazama H, Kikuchi H, Hiramoto M, Tsukahara K, Miyazawa K.
- Journal Title
  
  Int J Oncol.
  
  Volume: 60 Issue: 5 Pages: 54-54
- DOI
  10.3892/ijo.2022.5344
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08970, KAKENHI-PROJECT-21K07106, KAKENHI-PROJECT-20K16348, KAKENHI-PROJECT-20K07298
[Journal Article] p53 regulates lysosomal membrane permeabilization as well as cytoprotective autophagy in response to DNA-damaging drugs2022
- Author(s)
  Yamashita G, Takano N, Kazama H, Tsukahara K, Miyazawa K.
- Journal Title
  
  Cell Death Discov.
  
  Volume: 8 Issue: 1 Pages: 502-502
- DOI
  10.1038/s41420-022-01293-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08970, KAKENHI-PROJECT-20K07298
[Journal Article] Comparison of autophagy inducibility in various tyrosine kinase inhibitors and their enhanced cytotoxicity via inhibition of autophagy in cancer cells in combined treatment with azithromycin2020
- Author(s)
  Tanaka Hideki、Hino Hirotsugu、Moriya Shota、Kazama Hiromi、Miyazaki Masaya、Takano Naoharu、Hiramoto Masaki、Tsukahara Kiyoaki、Miyazawa Keisuke
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 22 Pages: 100750-100750
- DOI
  10.1016/j.bbrep.2020.100750
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06901, KAKENHI-PROJECT-19K07107, KAKENHI-PROJECT-18K15031, KAKENHI-PROJECT-17K08771, KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-20K08970, KAKENHI-PROJECT-17K15031
[Journal Article] Abemaciclib induces atypical cell death in cancer cell characterized by formation of cytoplasmic vacuoles derived from lysosomes2020
- Author(s)
  Hino Hirotsugu, Iriyama Noriyoshi, Kokuba Hiroko, Kazama Hiromi, Moriya Shota, Takano Naoharu, Hiramoto Masaki, Aizawa Shin, Miyazawa Keisuke
- Journal Title
  
  Cancer Science
  
  Volume: － Issue: 6 Pages: 2132-2145
- DOI
  10.1111/cas.14419
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15031, KAKENHI-PROJECT-17K08771, KAKENHI-PROJECT-19K07107, KAKENHI-PROJECT-20K08970, KAKENHI-PROJECT-18K06846, KAKENHI-PROJECT-18K06901, KAKENHI-PROJECT-17K15031
[Journal Article] Association of BRCA Mutantations and BRCAness Status With Anticancer Drug Sensitivities in Triple-Negative Breast Cancer Cell Lines2020
- Author(s)
  Teraoka S, Muguruma M, Takano N, Miyahara K, Kawate T, Kaise H, Yamada K, Miyazawa K, Ishikawa T.
- Journal Title
  
  J Surg Res.
  
  Volume: 250 Pages: 200-208
- DOI
  10.1016/j.jss.2019.12.040
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08771, KAKENHI-PROJECT-17K15031
[Journal Article] Fingolimod/FTY720 sensitizes EGFR wild-type non-small cell lung cancer cells to lapatinib or sorafenib and induces cell cycle arrest.2019
- Author(s)
  Ohta　K, Ohkuma T, Lorenzo AD, Yokota A, Hino H, Kazama H, Moriya S, Takano N, Hiramoto M, Miyazawa K.
- Journal Title
  
  Oncol Rep.
  
  Volume: - Pages: 231-242
- DOI
  10.3892/or.2019.7140
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08771, KAKENHI-PROJECT-18K06901, KAKENHI-PROJECT-18K15031, KAKENHI-PROJECT-16K19187, KAKENHI-PROJECT-16K21388, KAKENHI-PROJECT-19K07107, KAKENHI-PROJECT-17K15031
[Journal Article] Glutaminase 1 expression in colorectal cancer cells is induced by hypoxia and required for tumor growth, invasion, and metastatic colonization2019
- Author(s)
  Xiang Lisha、Mou Jun、Shao Bin、Wei Yuquan、Liang Houjie、Takano Naoharu、Semenza Gregg L.、Xie Ganfeng
- Journal Title
  
  Cell Death & Disease
  
  Volume: 10 Issue: 2
- DOI
  10.1038/s41419-018-1291-5
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15031
[Journal Article] Vitamin K2 induces non-apoptotic cell death along with autophagosome formation in breast cancer cell lines2019
- Author(s)
  Miyazawa Shinsuke、Moriya Shota、Kokuba Hiroko、Hino Hirotsugu、Takano Naoharu、Miyazawa Keisuke
- Journal Title
  
  Breast Cancer
  
  Volume: 27 Issue: 2 Pages: 225-235
- DOI
  10.1007/s12282-019-01012-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07107, KAKENHI-PROJECT-18K15031, KAKENHI-PROJECT-17K08771, KAKENHI-PROJECT-17K15031
[Journal Article] Amino acid starvation culture condition sensitizes EGFR-expressing cancer cell lines to gefitinib-mediated cytotoxicity by inducing atypical necroptosis.2018
- Author(s)
  Saito Y, Moriya S, Kazama H, Hirasawa K, Miyahara K, Kokuba H, Hino H, Kikuchi　H, Takano N, Hiramoto M, Tsukahara K, Miyazawa K.
- Journal Title
  
  Int J Oncol.
  
  Volume: 52 Pages: 1165-1177
- DOI
  10.3892/ijo.2018.4282
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08771, KAKENHI-PROJECT-16K19187, KAKENHI-PROJECT-16K21387, KAKENHI-PROJECT-16K21388, KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-17K15031
[Journal Article] Designing an effective drug combination for ER stress loading in cancer therapy　using a real-time monitoring system2018
- Author(s)
  Kazama H, Hiramoto M, Miyahara K, Takano N, Miyazawa K.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: - Issue: 1 Pages: 286-292
- DOI
  10.1016/j.bbrc.2018.05.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08771, KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-18K06901, KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-16K21388, KAKENHI-PROJECT-17K15031
[Presentation] DNA障害性薬剤により活性化されたp53は、リソソーム膜透過性の亢進と細胞保護的なオートファジーを同時に誘導する2022
- Author(s)
  山下凱、高野直治、風間宏美、塚原清彰、宮澤啓介
- Organizer
  第95回　日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K07298
[Presentation] DNA-damaging anticancer drugs induce cytotoxic lysosomal membrane permeabilization and cell protective autophagy via p532022
- Author(s)
  高野直治　風間宏美　宮澤啓介
- Organizer
  第81回　日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07298
[Presentation] BRCA1 degradation in response to mitochondrial damage in breast cancer cells2020
- Author(s)
  Kana Miyahara, Naoharu Takano, Yumiko Yamada, Hiromi Kazama, Mayumi Tokuhisa, Hirotsugu Hino, Koji Fujita, Edward Barroga, Masaki Hiramoto, Hiroshi Handa, Masahiko Kuroda, Takashi Ishikawa, Keisuke Miyazawa
- Organizer
  AACR Annual Meeting 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15031
[Presentation] Identification of the molecular target of azithromycin as an autophagy inhibitor and its potential application in cancer therapeutics2020
- Author(s)
  Naoharu Takano, Yumiko Yamada, Mayumi Tokuhisa, Hirotsugu Hino, Masaki Hiramoto, Keisuke Miyazawa.
- Organizer
  AACR Annual Meeting 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15031
[Presentation] Lysosome-targeted atypical cell-death with vacuolar formation by CDK4/6 inhibitor abemaciclib2019
- Author(s)
  Hirotsugu Hino, Hiromi Kazama, Shota Moriya, Naoharu Takano, Masaki Hiramoto, Keisuke Miyazawa
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K15031
[Presentation] Mitochondrial damage induces BRCA1 degradation in breast cancer cells2019
- Author(s)
  Naoharu Takano, Kana Miyahara, Hiromi Kazama, Hirotsugu Hino, Masaki Hiramoto, Masahiko Kuroda, Takashi Ishikawa, Keisuke Miyazawa
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K15031
[Presentation] 乳がん細胞におけるミトコンドリアダメージによって誘導されるBRCA1の新規分解機構2019
- Author(s)
  高野直治、宮原か奈、山田裕美子、風間宏美、徳久真弓、日野浩嗣、藤田浩司、Edward Barroga, 平本正樹、半田宏、黒田雅彦、石川　孝、宮澤啓介
- Organizer
  第92回大会　生化学会
- Data Source
  KAKENHI-PROJECT-17K15031
[Presentation] CDK4/6阻害薬abemaciclibによるリソソーム由来の空胞形成を伴った新規細胞死誘導2019
- Author(s)
  日野浩嗣、入山規良、國場寛子、風間宏美、森谷昇太、高野直治、平本正樹、宮澤啓介
- Organizer
  第92回大会　生化学会
- Data Source
  KAKENHI-PROJECT-17K15031
[Presentation] Actin cytoskeleton reorganization mediated by a cellular target of gefitinib.2019
- Author(s)
  Masaki Hiramoto, Naoharu Takano, Hiromi Kazama, Hirotsugu Hino, Keisuke Miyazawa
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K15031
[Presentation] Lysosome-targeted cytocidal effect of CDK4/6 inhibitor abemaciclib2018
- Author(s)
  Hirotsugu Hino, Hiromi Kazama, Shota Moriya, Naoharu Takano, Masaki Hiramoto, Keisuke Miyazawa
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K15031
[Presentation] Searching for molecular targets of gefitinib for autophagy regulation2018
- Author(s)
  Masaki Hiramoto, Hirotsugu Hino, Mayumi Tokuhisa, Hiromi Kazama, Naoharu Takano, Keisuke Miyazawa
- Organizer
  日本生化学会　第91回大会
- Data Source
  KAKENHI-PROJECT-17K15031
[Presentation] Identification of intracellular target of azithromycin as an autophagy inhibitor.2018
- Author(s)
  Naoharu Takano, Masaki Hiramoto, Keisuke Miyazawa
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K15031
[Presentation] CDK4/6阻害薬abemaciclibはmethuosis様の細胞死を誘導する2017
- Author(s)
  日野浩嗣、入山規良、國場寛子、風間宏美、森谷昇太、高野直治、平本正樹、宮澤啓介
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K15031
[Presentation] Amino Acids Starvation Enhances Gefitinib-Induced Cytotoxicity in EGFR-Expressing Cancer Cells via Atypical Necroptosis2017
- Author(s)
  Yu Saito, Shota Moriya、Hiromi Kazama、Kazuhiro Hirasawa、Kana Miyahara、Naoharu Takano、Masaki Hiramoto、Kiyoaki Tsukahara、Keisuke Miyazawa
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K15031
[Presentation] Determination of effective combination of agents for ER-stress loading in breast cancer cells with ERAI-venus system2017
- Author(s)
  Hiromi Kazama, Masaki Hiramoto、Kana Miyahara 、Naoharu Takano、Keisuke Miyazawa
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K15031
[Presentation] 翻訳後修飾を介した解糖系酵素PKM2の核移行メカニズムの解析2017
- Author(s)
  山本雄広、伊藤真衣、高野直治、石渡恭子、倉堀智一、末松誠
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K15031
[Presentation] Pyruvate kinase M2のメチル化修飾による機能変化の解析2010
- Author(s)
  高野直治・山本雄広・石渡恭子・末松誠
- Organizer
  第33回日本分子生物学会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド神戸国際展示場
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-22770197

1. 後藤明彦 (00297293)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 森下総司 (10635866)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 今井美沙 (50709003)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 平本正樹 (70297828)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. 川原玄理 (40743331)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 風間宏美

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 宮澤啓介

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
8. 日野浩嗣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 森谷昇太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takano Naoharu 高野 直治

高野 直治 タカノ ナオハル

Research Projects

Research Products

Co-Researchers

Regulatory mechanisms of epithelial-mesenchymal transition and cancer metastasis by GAK, a cellular target of EGFR tyrosine kinase inhibitors

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

がん細胞はどのようにオートファジーを用いて化学療法から生き残り再増殖するのかPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

骨髄増殖性腫瘍幹細胞におけるCD44を中心とする接着因子発現・機能の調節機構解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of autophagy Inhibitory mechanisms of azithromycin and its tumor inhibitory effect in the mice model for cancer therapy.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of cancer stem cell targeting therapy using autophagy inhibitory activity of macrolide antibioticsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

一酸化炭素によるタンパク質メチル化修飾を介した糖代謝制御と細胞機能制御の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Azithromycin, a potent autophagy inhibitor for cancer therapy, perturbs cytoskeletal protein dynamics2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ricolinostat enhances adavosertib&#8209;induced mitotic catastrophe in TP53&#8209;mutated head and neck squamous cell carcinoma cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] p53 regulates lysosomal membrane permeabilization as well as cytoprotective autophagy in response to DNA-damaging drugs2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comparison of autophagy inducibility in various tyrosine kinase inhibitors and their enhanced cytotoxicity via inhibition of autophagy in cancer cells in combined treatment with azithromycin2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Abemaciclib induces atypical cell death in cancer cell characterized by formation of cytoplasmic vacuoles derived from lysosomes2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of BRCA Mutantations and BRCAness Status With Anticancer Drug Sensitivities in Triple-Negative Breast Cancer Cell Lines2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fingolimod/FTY720 sensitizes EGFR wild-type non-small cell lung cancer cells to lapatinib or sorafenib and induces cell cycle arrest.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Glutaminase 1 expression in colorectal cancer cells is induced by hypoxia and required for tumor growth, invasion, and metastatic colonization2019

Author(s)

Journal Title

DOI

Takano Naoharu 高野直治

高野直治タカノナオハル

[Journal Article] Ricolinostat enhances adavosertib‑induced mitotic catastrophe in TP53‑mutated head and neck squamous cell carcinoma cells2022

[Journal Article] Designing an effective drug combination for ER stress loading in cancer therapy　using a real-time monitoring system2018