tomobe kouji 友部浩二

… Alternative Names

TOMOBE Koji 友部浩二

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Researcher Number	80460286
Affiliation (Current)	2025: 横浜薬科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2013 – 2015: 横浜薬科大学, 薬学部, 准教授 2008 – 2012: Yokohama College of Pharmacy, 薬学部, 講師 2011: 横浜薬科大学, 講師
Review Section/Research Field	Principal Investigator Biological pharmacy Except Principal Investigator Neurochemistry/Neuropharmacology / Biological Sciences / Neurochemistry/Neuropharmacology / Biological pharmacy
Keywords	Principal Investigator 蛋白質 / 小胞体ストレス / 老化促進マウ / 酸化ストレス / 老化促進マウス / 老化 Except Principal Investigator 小胞体ストレス / アルツハイマー病 / ERAD / ユビキチンリガーゼ … More / APP / Dorfin / 神経細胞 / アミロイドβ / γ-セクレターゼ / 酸化ストレス / 構造活性相関 / パーキンソン病 / ケミカルシャペロン / 神経変性疾患 / ノックアウトマウス / 質量分析 / HRD1 / RNF1９B / EDAD / 小胞体 / エンドソーム / RNF19B / 膜輸送 / バイオインフォマティクス / Notch / Parkin / Aβ / 不溶化 / 神経細胞死 / PKC Less

Involvement of novel ubiquitin ligases in the pathogenic mechanism of Alzheimer's disease and drug discovery for fundamental therapeutic agent
- Principal Investigator
  
  Nomura Yasuyuki
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kurume University
  Yokohama College of Pharmacy
新規ユビキチンリガーゼによる小胞体のタンパク質分解機構
- Principal Investigator
  
  金子雅幸
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba Institute of Science
The inhibitory mechanism of unfolded protein accumulation in the endoplasmic reticulum : Studies on anti-neurodegeneration drug discovery
- Principal Investigator
  
  NOMURA Yasuyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Yokohama College of Pharmacy
Study on the mechanism underling development of neurodegenerative diseases with age-related dysfunction of the endoplasmic reticulumPrincipal Investigator
- Principal Investigator
  
  TOMOBE Koji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Yokohama College of Pharmacy
小胞体蓄積タンパク質の分解促進/凝集抑制活性を有する抗脳変性疾患薬の創製
- Principal Investigator
  
  野村靖幸
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Yokohama College of Pharmacy

All 2013 2011 2010 2009 2008

All Journal Article Presentation Book

[Book] The Senescence-accelerated Mouse (SAM): Achievements and Future Directions2013
- Author(s)
  Tomobe K, Isobe M, Nomura Y
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-24300135
[Journal Article] Age-related changes of Nrf2 and phosphorylated GSK-3b in a mouse model of accelerated aging (SAMP8).2011
- Author(s)
  Tomobe K., Shinozuka T., Kuroiwa M., Nomura Y.
- Journal Title
  
  Arch.Gerontol.Geriatr. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590095
[Journal Article] Neurochemistry, Neuropathology, and Heredity in SAMP8 : A Mouse Model of Senescence.2009
- Author(s)
  Tomobe K., Nomura Y
- Journal Title
  
  Neurochem.Res. 34(4)
  
  Pages: 660-669
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590095
[Journal Article] Neurochemistry, Neuropathology, and Heredity in SAMP8 : A Mouse Model of Senescence2009
- Author(s)
  K.Tomobe
- Journal Title
  
  Neurochem. Res. 34
  
  Pages: 660-669
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590095
[Journal Article] Neurochemistry, neuropathology, and heredity in SAMP8 : a mouse model of senescence2009
- Author(s)
  Tomobe, K.
- Journal Title
  
  Neurochem. Res. 34
  
  Pages: 660-669
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659013
[Journal Article] Neurochemistry, Neuropathology, and Heredity in SAMP8 : A Mouse Model of Senescence2009
- Author(s)
  K. Tomobe
- Journal Title
  
  Neurochem. Res. 34
  
  Pages: 660-669
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590095
[Presentation] LPS誘導の骨量減少に対する低線量X線照射の影響2011
- Author(s)
  倉岡貴徳,小林芳子,出雲信夫,友部浩二,野村靖幸,加藤真介
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-20590095
[Presentation] 骨量減少症モデルマウスに対する低線量X線の影響2010
- Author(s)
  小林芳子,出雲信夫,友部浩二,野村靖幸,加藤真介
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20590095
[Presentation] 低線量X線連続照射のマウス骨量への影響2009
- Author(s)
  出雲信夫,小林芳子,友部浩二,西廣吉,野村靖幸,加藤真介
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590095
[Presentation] SAMP8における学習記憶障害遺伝子の連鎖解析2008
- Author(s)
  友部浩二,磯部正治,近藤綾子,澤田昌伸,黒澤信幸,野村靖幸
- Organizer
  第23回老化促進モデルマウス(SAM)研究協議会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590095

1. NOMURA Yasuyuki (00034041)

# of Collaborated Projects: 5 results

# of Collaborated Products: 7 results
2. KANEKO Masayuki (10322827)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. OKUMA Yasunobu (20127939)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. TAKAHASHI Ryosuke (90216771)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SHINOZUKA Tatsuo (70095610)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. IZUMO Nobuo (70368976)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TONOOKA Keiko (20521884)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. HAMANA Hiroshi (00383472)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Sobue Gen (20148315)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Kitamura Yoshihisa (60195295)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Ishigaki Shinsuke (40378170)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Takata Kazuyuki (10434664)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Kawada Koichi (30581631)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

tomobe kouji 友部 浩二

TOMOBE Koji 友部 浩二

Research Projects

Research Products

Co-Researchers

Involvement of novel ubiquitin ligases in the pathogenic mechanism of Alzheimer's disease and drug discovery for fundamental therapeutic agent

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

新規ユビキチンリガーゼによる小胞体のタンパク質分解機構

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The inhibitory mechanism of unfolded protein accumulation in the endoplasmic reticulum : Studies on anti-neurodegeneration drug discovery

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the mechanism underling development of neurodegenerative diseases with age-related dysfunction of the endoplasmic reticulumPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

小胞体蓄積タンパク質の分解促進/凝集抑制活性を有する抗脳変性疾患薬の創製

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] The Senescence-accelerated Mouse (SAM): Achievements and Future Directions2013

Author(s)

Publisher

Data Source

[Journal Article] Age-related changes of Nrf2 and phosphorylated GSK-3b in a mouse model of accelerated aging (SAMP8).2011

Author(s)

Journal Title

Data Source

[Journal Article] Neurochemistry, Neuropathology, and Heredity in SAMP8 : A Mouse Model of Senescence.2009

Author(s)

Journal Title

Data Source

[Journal Article] Neurochemistry, Neuropathology, and Heredity in SAMP8 : A Mouse Model of Senescence2009

Author(s)

Journal Title

Data Source

[Journal Article] Neurochemistry, neuropathology, and heredity in SAMP8 : a mouse model of senescence2009

Author(s)

Journal Title

Data Source

[Journal Article] Neurochemistry, Neuropathology, and Heredity in SAMP8 : A Mouse Model of Senescence2009

Author(s)

Journal Title

Data Source

[Presentation] LPS誘導の骨量減少に対する低線量X線照射の影響2011

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 骨量減少症モデルマウスに対する低線量X線の影響2010

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 低線量X線連続照射のマウス骨量への影響2009

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] SAMP8における学習記憶障害遺伝子の連鎖解析2008

Author(s)

Organizer

Place of Presentation

Data Source

tomobe kouji 友部浩二

TOMOBE Koji 友部浩二