Yamakawa Hiroyuki 山川裕之

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YAMAKAWA Hiroyuki 山川裕之

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Researcher Number	80465020
Affiliation (Current)	2025: 慶應義塾大学, 医学部(信濃町), 講師
Affiliation (based on the past Project Information) *help	2023 – 2024: 慶應義塾大学, 医学部(信濃町), 講師 2021: 慶應義塾大学, 医学部(信濃町), 講師 2018 – 2020: 慶應義塾大学, 医学部(信濃町), 助教 2018: 慶應義塾大学, 医学部(信濃町), 客員講師 2017: 慶應義塾大学, 医学部, 客員講師 … More 2016: 慶應義塾大学, 医学部(信濃町), 共同研究員 2015: 慶應義塾大学, 医学部, 研究員 2008: 慶應義塾大学, 医学部, 助教 Less
Review Section/Research Field	Principal Investigator Basic Section 49030:Experimental pathology-related / Basic Section 53020:Cardiology-related / Cardiovascular medicine Except Principal Investigator Basic Section 52040:Radiological sciences-related / Circulatory organs internal medicine
Keywords	Principal Investigator 再生医療 / 直接リプログラミング / 心筋再生 / 創薬開発 / サルコペニア / 筋衛星細胞 / 骨格筋 / 直接誘導 / プログラミング / 遺伝子導入 … More / リプロウグラミング / 心筋梗塞 / 遺伝子編集 / リプログラミング / 遺伝子治療 / 心筋リプロウグラミング / 心筋リプログラミング / 心筋症 / 繊維芽細胞 / 線維芽細胞 / iPS細胞 / 生体内リプログラミング / 心筋転写因子 / ダイレクトリプログラミング / 心筋直接誘導 … More Except Principal Investigator 解明 / 病態解明 / 健康寿命 / computed tomography / 加齢 / 画像 / 座位 / 立位 / CT / 細胞内カルシウム濃度 / カルシウムチャネル / 低分子量G蛋白質 Less

サルコペニア改善するための筋衛星細胞をターゲットとした骨格筋再生の創薬開発Principal Investigator
- Principal Investigator
  
  山川裕之
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Keio University
Elucidation of age-related changes and pathology and establishment of a method for early detection of diseases using upright CT: Aiming at extending healthy life expectancy
- Principal Investigator
  
  山田祥岳
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Keio University
Fundamental research on direct myocardial reprogramming of the myocardium for biotransformation into infarct lesions.Principal Investigator
- Principal Investigator
  
  YAMAKAWA Hiroyuki
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Keio University
The making of the pacemaker cell by the direct cardiac reprogramming and in vivo transformationPrincipal Investigator
- Principal Investigator
  
  YAMAKAWA Hiroyuki
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Keio University
Role of small G protein Rad in diabetic cardiomyopathy
- Principal Investigator
  
  MURATA Mitsushige
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Keio University

All 2021 2020 2019 2018 2017 2016 2015 2009 2008

All Journal Article Presentation

[Journal Article] Thyroid Hormone Plays an Important Role in Cardiac Function: From Bench to Bedside.2021
- Author(s)
  Yamakawa H, Kato TS, Noh JY, Yuasa S, Kawamura A, Fukuda K, Aizawa Y.
- Journal Title
  
  Front Physiol.
  
  Volume: 12 Pages: 606931-606931
- DOI
  10.3389/fphys.2021.606931
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09524, KAKENHI-PROJECT-18K08047, KAKENHI-PROJECT-20H03678
[Journal Article] Overexpression of Gata4, Mef2c, and Tbx5 Generates Induced Cardiomyocytes Via Direct Reprogramming and Rare Fusion in the Heart2021
- Author(s)
  Isomi Mari、Sadahiro Taketaro、Yamakawa Hiroyuki、Fujita Ryo、Yamada Yu、Abe Yuto、Murakata Yoshiko、Akiyama Tatsuya、Shu Tsugumine、Mizukami Hiroaki、Fukuda Keiichi、Ieda Masaki
- Journal Title
  
  Circulation
  
  Volume: 143 Issue: 21 Pages: 2123-2125
- DOI
  10.1161/circulationaha.120.052799
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04179, KAKENHI-PROJECT-18K08047, KAKENHI-PROJECT-19K22613, KAKENHI-PROJECT-21K19471, KAKENHI-PROJECT-20K23283
[Journal Article] Cardiac regeneration by direct reprogramming in this decade and beyond2021
- Author(s)
  Yamakawa Hiroyuki、Ieda Masaki
- Journal Title
  
  Inflammation and Regeneration
  
  Volume: 41 Issue: 1
- DOI
  10.1186/s41232-021-00168-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08047
[Journal Article] Stem Cell Aging in Skeletal Muscle Regeneration and Disease2020
- Author(s)
  Yamakawa Hiroyuki、Kusumoto Dai、Hashimoto Hisayuki、Yuasa Shinsuke
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 5 Pages: 1830-1830
- DOI
  10.3390/ijms21051830
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08047, KAKENHI-PROJECT-16H05304
[Journal Article] Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming2019
- Author(s)
  Muraoka Naoto、Nara Kaori、Tamura Fumiya、Kojima Hidenori、Yamakawa Hiroyuki、Sadahiro Taketaro、Miyamoto Kazutaka、Isomi Mari、Haginiwa Sho、Tani Hidenori、Kurotsu Shota、Osakabe Rina、Torii Satoru、Shimizu Shigeomi、Okano Hideyuki、Sugimoto Yukihiko、Fukuda Keiichi、Ieda Masaki
- Journal Title
  
  Nature Communications
  
  Volume: 10 Issue: 1 Pages: 674-674
- DOI
  10.1038/s41467-019-08626-y
- NAID
  120007128245
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06210, KAKENHI-PROJECT-18K08047, KAKENHI-PROJECT-18K08114, KAKENHI-PROJECT-17K16024, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05905, KAKENHI-PLANNED-17H06414, KAKENHI-PROJECT-17H01533, KAKENHI-PROJECT-17H03990, KAKENHI-PROJECT-17J06637, KAKENHI-PROJECT-18J21479, KAKENHI-PROJECT-15K09147, KAKENHI-PROJECT-16K19426, KAKENHI-PROJECT-19K22503
[Journal Article] Direct In Vivo Reprogramming with Sendai Virus Vectors Improves Cardiac Function after Myocardial Infarction.2018
- Author(s)
  Miyamoto K, Akiyama M, Tamura F, Isomi M, Yamakawa H, Sadahiro T, Muraoka N, Kojima H, Haginiwa S, Kurotsu S, Tani H, Wang L, Qian L, Inoue M, Ide Y, Kurokawa J, Yamamoto T, Seki T, Aeba R, Yamagishi H, Fukuda K, Ieda M.
- Journal Title
  
  Cell Stem Cell.
  
  Volume: 4 Issue: 1 Pages: 91-103
- DOI
  10.1016/j.stem.2017.11.010
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09147, KAKENHI-PROJECT-17K19678, KAKENHI-PROJECT-16K19426, KAKENHI-PROJECT-15H04684, KAKENHI-PROJECT-26293193, KAKENHI-PROJECT-16H05359, KAKENHI-PROJECT-15K15313, KAKENHI-PROJECT-16K19428, KAKENHI-PROJECT-17H04179
[Journal Article] Single-Construct Polycistronic Doxycycline-Inducible Vectors Improve Direct Cardiac Reprogramming and Can Be Used to Identify the Critical Timing of Transgene Expression.2017
- Author(s)
  Umei TC, Yamakawa H, Muraoka N, Sadahiro T, Isomi M, Haginiwa S, Kojima H, Kurotsu S, Tamura F, Osakabe R, Tani H, Nara K, Miyoshi H, Fukuda K, Ieda M.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 18 Issue: 8 Pages: 1805-1805
- DOI
  10.3390/ijms18081805
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09147, KAKENHI-PROJECT-17K19678, KAKENHI-PROJECT-16K19426, KAKENHI-PROJECT-26293193, KAKENHI-PROJECT-15K15313, KAKENHI-PROJECT-17H04179
[Journal Article] Comment on: Expandable cardiovascular progenitor cells reprogrammed from fibroblasts.2016
- Author(s)
  Yamakawa H, Fukuda K.
- Journal Title
  
  Stem Cell Investig.
  
  Volume: - Pages: 89-89
- DOI
  10.21037/sci.2016.11.07
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09147
[Journal Article] Approaches Ranging from Induced Pluripotent Stem Cells to Direct Cardiac Reprogramming2015
- Author(s)
  Yamakawa H, Ieda M
- Journal Title
  
  Int. Heart J.
  
  Volume: 56 Issue: 1 Pages: 1-5
- DOI
  10.1536/ihj.14-344
- NAID
  130004941301
- ISSN
  1349-2365, 1349-3299
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25670394, KAKENHI-PROJECT-15K09147
[Journal Article] Strategies for heart regeneration: approaches ranging from induced pluripotent stem cells to direct cardiac reprogramming.2015
- Author(s)
  Yamakawa H, Ieda M.
- Journal Title
  
  Int Heart J
  
  Volume: 56 Issue: 6 Pages: 1-5
- DOI
  10.1016/j.stemcr.2015.10.019
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09147, KAKENHI-PROJECT-15K15049, KAKENHI-PROJECT-15K15313, KAKENHI-PROJECT-15H04684, KAKENHI-PROJECT-15J07407, KAKENHI-PROJECT-25670394, KAKENHI-PROJECT-26293193, KAKENHI-PROJECT-26293052
[Presentation] 女性ファブリー病における低心機能の患者の管理と、地域連携および在宅医療への導出方法2021
- Author(s)
  山川裕之
- Organizer
  第25回　日本心不全学会
- Data Source
  KAKENHI-PROJECT-18K08047
[Presentation] 先天代謝異常症の成人移行支援（内科専門医の立場より）2021
- Author(s)
  山川裕之
- Organizer
  第62回日本先天性代謝異常学会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08047
[Presentation] 我が国における在宅酵素補充療法の実現に向けての提言2021
- Author(s)
  山川裕之
- Organizer
  厚生労働省難治性疾患政策研究事業ライソゾーム病・ペルオキシソーム病における良質かつ適切な医療の実現に向けた体制の構築とその実装に関する研究班
- Invited
- Data Source
  KAKENHI-PROJECT-18K08047
[Presentation] A case of myeloma cast nephropathy complicated by Fabry disease after withdrawal from dialysis2020
- Author(s)
  Hiroyuki Yamakawa
- Organizer
  WORLDSymposium 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08047
[Presentation] マルチモダリティーを用いた心臓病理の解釈ミクロレベル編・マクロレベル編2020
- Author(s)
  山川裕之
- Organizer
  第24回日本心不全学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08047
[Presentation] 心筋症の鑑別　ファブリー病2020
- Author(s)
  山川裕之
- Organizer
  第24回日本心不全学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08047
[Presentation] Fabry disease has been found by using of the tumor mutational burden analysis of 3000 Japanese cancer genimis using whole genome exome and targeted gene panel seqencing:Project Hightech Omics-based Patient Evaluation (Project HOPE)2019
- Author(s)
  Hiroyuki YAMAKAWA
- Organizer
  WORLDSymposim 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09147
[Presentation] Fabry disease has been found by using of the tumor mutational burden analysis of 3000 Japanese cancer genimis using whole genome exome and targeted gene panel seqencing:Project Hightech Omics-based Patient Evaluation (Project HOPE) （2／2019
- Author(s)
  Hiroyuki YAMAKAWA
- Organizer
  WORLDSymposim 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08047
[Presentation] FGF2/FGF10/VEGFが、心筋直接フル・リプログラミングを効率的に誘導する2016
- Author(s)
  山川裕之
- Organizer
  第15回再生医療学会
- Place of Presentation
  大阪国際会議（大阪府大阪市北区）
- Year and Date
  2016-03-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09147
[Presentation] 増殖因子による心筋リプログラミングの促進と分子機構の解明2016
- Author(s)
  山川裕之
- Organizer
  第15回再生医療学会
- Place of Presentation
  大阪国際会議（大阪府大阪市北区）
- Year and Date
  2016-03-17
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09147
[Presentation] 特定の化合物が、心筋直接フル･リプログラミングを促進する2015
- Author(s)
  山川裕之
- Organizer
  第36回日本炎症・再生医学会
- Place of Presentation
  虎ノ門ヒルズフォーラム（東京都港区）
- Year and Date
  2015-07-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09147
[Presentation] Chemical Compounds Greatly Increase Direct Cardiac Reprogramming under Defined Conditions2015
- Author(s)
  山川裕之
- Organizer
  第79回日本循環器学会
- Place of Presentation
  大阪国際会議（大阪府大阪市北区）
- Year and Date
  2015-04-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09147
[Presentation] Regulation of sarcoplasmic reticulum Ca2+ leak by small G protein Rad in the heart2009
- Author(s)
  Murata M, Yamakawa H, Yada H, Makino S, Sano M, Ogawa S, Fukuda K
- Organizer
  第73回日本循環器学会学術集会(シンポジウム)
- Place of Presentation
  大阪
- Year and Date
  2009-03-22
- Data Source
  KAKENHI-PROJECT-19790541
[Presentation] Regulation of intracellular Ca2+ homeostasis by a ras-related small G-protein Rad in the heart2008
- Author(s)
  Murata M, Yada H, Yamakawa H, Murata M, Ogawa S, Fukuda K
- Organizer
  The International Discussion Forum & the 242nd Tokyo Discussion Meeting of the Physiological Society of Japan
- Place of Presentation
  東京
- Year and Date
  2008-10-26
- Data Source
  KAKENHI-PROJECT-19790541
[Presentation] Dominant negative suppression of Rad leads to intracellular Ca2+ overload via up-regulation of cardiac ryanodine receptor activity2008
- Author(s)
  Murata M, Yada H, Yamakawa H, Aizawa Y, Yuasa S, Hakuno D, Makino S, Sano M, Murata M, Ogawa S, Fukuda K
- Organizer
  81st American Heart Association scientific meeting
- Place of Presentation
  New Orleans, USA
- Year and Date
  2008-11-13
- Data Source
  KAKENHI-PROJECT-19790541
[Presentation] Dominant negative suppression of Rad leads to intracellular Ca2+ overload via up-regulation of cardiac ryanodine receptor activity2008
- Author(s)
  Murata M, Yada H, Yamakawa H, Murata M, Ogawa S, Fukuda K
- Organizer
  The 25th the Annual Meeting of International Society for Heart Research Japanese Section(ISHR)
- Place of Presentation
  横浜
- Year and Date
  2008-12-05
- Data Source
  KAKENHI-PROJECT-19790541

1. MURATA Mitsushige (30317135)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
2. 山田祥岳 (60383791)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 山田稔 (60365434)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 横山陽一 (20936744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 井上政則 (30338157)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 鈴木達也 (70627166)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 遠藤維 (40599073)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 陣崎雅弘 (80216259)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. AIZAWA Yoshiyasu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. TORII Satoru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 家田真樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamakawa Hiroyuki 山川 裕之

YAMAKAWA Hiroyuki 山川 裕之

Research Projects

Research Products

Co-Researchers

サルコペニア改善するための筋 衛星細胞をターゲットとした骨 格筋再生の創薬開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of age-related changes and pathology and establishment of a method for early detection of diseases using upright CT: Aiming at extending healthy life expectancy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Fundamental research on direct myocardial reprogramming of the myocardium for biotransformation into infarct lesions.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The making of the pacemaker cell by the direct cardiac reprogramming and in vivo transformationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of small G protein Rad in diabetic cardiomyopathy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Thyroid Hormone Plays an Important Role in Cardiac Function: From Bench to Bedside.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Overexpression of Gata4, Mef2c, and Tbx5 Generates Induced Cardiomyocytes Via Direct Reprogramming and Rare Fusion in the Heart2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cardiac regeneration by direct reprogramming in this decade and beyond2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Stem Cell Aging in Skeletal Muscle Regeneration and Disease2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Direct In Vivo Reprogramming with Sendai Virus Vectors Improves Cardiac Function after Myocardial Infarction.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Single-Construct Polycistronic Doxycycline-Inducible Vectors Improve Direct Cardiac Reprogramming and Can Be Used to Identify the Critical Timing of Transgene Expression.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comment on: Expandable cardiovascular progenitor cells reprogrammed from fibroblasts.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Approaches Ranging from Induced Pluripotent Stem Cells to Direct Cardiac Reprogramming2015

Author(s)

Journal Title

DOI

Yamakawa Hiroyuki 山川裕之

YAMAKAWA Hiroyuki 山川裕之

サルコペニア改善するための筋衛星細胞をターゲットとした骨格筋再生の創薬開発Principal Investigator

[Presentation] マルチモダリティーを用いた心臓病理の解釈ミクロレベル編・マクロレベル編2020

[Presentation] 心筋症の鑑別　ファブリー病2020