SAEKI Norihisa 佐伯宣久

… Alternative Names

佐伯宣久サエキノリヒサ

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Researcher Number	80466200
Other IDs
Affiliation (Current)	2025: 沖縄県立看護大学, 看護学部, 教授
Affiliation (based on the past Project Information) *help	2015: 国立研究開発法人国立がん研究センター, 研究所, 主任研究員 2013 – 2014: 独立行政法人国立がん研究センター, その他部局等, 主任研究員 2011 – 2014: 独立行政法人国立がん研究センター, 研究所, 主任研究員
Review Section/Research Field	Principal Investigator Pediatrics / Cancer epidemiology and prevention Except Principal Investigator Clinical oncology
Keywords	Principal Investigator 創薬標的分子 / LMO1 / マイクロRNA / microRNA / 治療標的分子 / 転写調節因子 / がん遺伝子 / 神経芽腫 / PSCA / 易罹患性遺伝子 … More / 胃がん予防 / がん抑制分子経路 / 細胞内シグナル伝達 / GPIアンカー型膜タンパク / 胃がん易罹患性遺伝子 / 胆のうがん / がん抑制遺伝子 / 疾患感受性遺伝子 / 胃がん … More Except Principal Investigator 癌 / 胃がん / びまん型胃がん / 遺伝子治療 Less

Exploration of microRNA regulated by LMO1, a neuroblastoma oncogenePrincipal Investigator
- Principal Investigator
  
  Saeki Norihisa
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pediatrics
- Research Institution
  National Cancer Center Japan
Development of vector specific to diffuse-type gastric cancer cells for peritoneal metastasis control
- Principal Investigator
  
  SASAKI Hiroki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical oncology
- Research Institution
  National Center of Neurology and Psychiatry
Study of PSCA, a gastric cancer susceptibility genePrincipal Investigator
- Principal Investigator
  
  SAEKI Norihisa
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cancer epidemiology and prevention
- Research Institution
  National Cancer Center Japan

All 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Book

[Book] Prostate stem cell antigen and pancreatic cancer. In: Endocrine disease.2014
- Author(s)
  Saeki N, Ono H
- Publisher
  iConcept
- Data Source
  KAKENHI-PROJECT-23501327
[Book] Prostate stem cell antigen and pancreatic cancer. In: Endocrine disease.2014
- Author(s)
  Saeki N, Ono H.
- Total Pages
  160
- Publisher
  iConcept Press Ltd.
- Data Source
  KAKENHI-PROJECT-23501327
[Book] Gasdermin superfamily : a novel gene family fuctioning in epithelial cells. In Endothelium and Epithelium : Composition and Functions. (Carrasco J and Mota M (edits))2012
- Author(s)
  Saeki N, Sasaki H
- Publisher
  Nova Science
- Data Source
  KAKENHI-PROJECT-23501322
[Journal Article] Tumor suppressive let-7 family microRNAs are indirectly down-regulated by LMO1 in neuroblastoma.2016
- Author(s)
  Saeki N, Saito A, Sugaya Y, Mitsuhiro Amemiya M, Sasaki H.
- Journal Title
  
  Oncol Lett
  
  Volume: 未定
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26670510
[Journal Article] Chromatin immunoprecipitation and DNA sequencing identified a LIMS1/ILK pathway regulated by an oncogenic transcription factor LMO1 in neuroblastoma.2016
- Author(s)
  Saeki N, Saito A, Sugaya Y, Mitsuhiro Amemiya M, Ono H, Komatsuzaki R, Yanagihara K, Sasaki H.
- Journal Title
  
  Oncol Lett
  
  Volume: 未定
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26670510
[Journal Article] Down-regulation of immune-related genes by PSCA in gallbladder cancer cells implanted into mice.2015
- Author(s)
  Saeki N, Ono H, Sakamoto H, Yoshida T.
- Journal Title
  
  Anticancer Research
  
  Volume: 35 Pages: 2619-2625
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23501327
[Journal Article] rs2294008 T, a risk allele for gastric and gallbladder cancers, suppresses a PSCA promoter by recruiting a transcription factor YY1.2015
- Author(s)
  Saeki N, Ono H, Yanagihara K, Aoyagi K, Sasaki H, Sakamoto H, Yoshida T.
- Journal Title
  
  Genes to Cells
  
  Volume: 29 Issue: 5 Pages: 382-391
- DOI
  10.1111/gtc.12228
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23501327
[Journal Article] Missense allele of a single nucleotide polymorphism rs2294008 attenuated anti-tumor effects of prostate stem cell antigen (PSCA) in gallbladder cancer cells.2013
- Author(s)
  Ono H, Chihara D, Chiwaki F, Yanagihara K, Sasaki H, Sakamoto H, Tanaka H, Yoshida T, Saeki N, Matsuo K.
- Journal Title
  
  J Carcinog
  
  Volume: 12 Issue: 1 Pages: 4-4
- DOI
  10.4103/1477-3163.109030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501327
[Journal Article] Five gastric cancer-susceptibility loci identified by genome-wide association studies.2013
- Author(s)
  Ono H, Saeki N
- Journal Title
  
  J Gastroint Dig Sys
  
  Volume: S12 Pages: 15-15
- DOI
  10.4172/2161-069x.s12-015
- Data Source
  KAKENHI-PROJECT-23501327
[Journal Article] Genetic factors related to gastric cancer susceptibility identified using a genome-wide association study.2013
- Author(s)
  Saeki N, Ono H, Sakamoto H, Yoshida T.
- Journal Title
  
  Cancer Sci.
  
  Volume: 104 Issue: 1 Pages: 1-8
- DOI
  10.1111/cas.12042
- Data Source
  KAKENHI-PROJECT-23501327
[Journal Article] Prostate stem cell antigen gene is expressed in islets of pancreas.2012
- Author(s)
  Ono H, Yanagihara K, Sakamoto H, Yoshida T, Saeki N.
- Journal Title
  
  Anat Cell Biol.
  
  Volume: 45 Issue: 3 Pages: 149-154
- DOI
  10.5115/acb.2012.45.3.149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501327
[Journal Article] Chromosome 1q22 is a susceptibility locus of diffuse-type gastric cancer, harboring a functional SNP of MUC12011
- Author(s)
  Saeki N, Saito A, Choi JI, Matsuno K, Ohnami S, Totsuka H, Chiku S, Kuchiba A, Lee Y-S, Yoon K-A, Kook M-C, Park SR, Kim Y-W, Tanaka H, Tajima K, Hirose H, Tanioka F, Matsuno Y, Sugimura H, Kato S, Nakamura T, Nishina T, Yasui W, Aoyagi K, Sasaki H, Yanagihara K, Katai H, Shimoda T, Yoshida T, Nakamura Y, Hirohashi S, Sakamoto H
- Journal Title
  
  Gastroenterology
  
  Volume: 140 Pages: 892-902
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501322
[Presentation] 神経芽腫において転写調節因子LMO1が制御する分子経路2016
- Author(s)
  佐伯宣久
- Organizer
  第119回日本小児科学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2016-05-13
- Data Source
  KAKENHI-PROJECT-26670510
[Presentation] がん促進転写調節因子LMO1の標的遺伝子探索により同定されたLIMS1/ILK分子経路は神経芽腫の新規治療標的である2015
- Author(s)
  佐伯宣久、斎藤聡、小野弘恵、小松崎理絵、佐々木博己
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26670510
[Presentation] ChIP-Seqを用いたがん促進転写調節因子LMO1の制御標的遺伝子同定による新たな神経芽腫治療標的分子経路の探索2015
- Author(s)
  佐伯宣久、斎藤聡、菅谷勇樹、雨宮光宏、小野弘恵、小松崎理絵、佐々木博己
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26670510
[Presentation] Towards the genetics and genomics of diffuse gastric cancer2013
- Author(s)
  Hiromi Sakamoto, Norihisa Saeki, Hidemi Itoh, Keitaro Matsuo, Hidetaka Yamada, Haruhiko Sugimura, Hitoshi Ichikawa, Hiroki Sasaki, Teruhiko Yoshida
- Organizer
  The 4^<th> JCA-AACR Special Joint Conference
- Data Source
  KAKENHI-PROJECT-23501322
[Presentation] 胃がん・膀胱がん易罹患性関連遺伝子PSCA上のミスセンスSNPは胆のうがん細胞においてPSCAのがん抑制機能を減弱させる.2012
- Author(s)
  小野弘恵、千原大、千脇史子、佐々木博己、坂本裕美、吉田輝彦、松尾恵太郎、佐伯宣久.
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23501327
[Presentation] Gastric-cancer susceptibility genes identified through collaboration between Japanese and Korean research groups.2012
- Author(s)
  Saeki N, Ono H, Sakamoto H, Yoshida T.
- Organizer
  The 17th Japan-Korea Cancer Research Workshop
- Place of Presentation
  Busan Korea
- Data Source
  KAKENHI-PROJECT-23501327
[Presentation] 胃がんのゲノム網羅的遺伝素因の探索2011
- Author(s)
  坂本裕美、佐伯宣久、斎藤聡、松尾恵太郎、佐々木博己、大浪澄子、小野弘恵、片井均、椙村春彦、吉田輝彦
- Organizer
  第70回日本癌学会、シンポジウム
- Data Source
  KAKENHI-PROJECT-23501322
[Presentation] 胃がんのゲノム網羅的関連解析2011
- Author(s)
  吉田輝彦、佐伯宣久、斎藤聡、松尾恵太郎、佐々木博己、大浪澄子、小野弘恵、坂本裕美、片井均
- Organizer
  第70回日本癌学会、シンポジウム
- Data Source
  KAKENHI-PROJECT-23501322
[Presentation] Prostate stem cell antigen (PSCA)の正常脳組織及び脳腫瘍での発現.
- Author(s)
  小野弘恵、坂本裕美、吉田輝彦、佐伯宣久
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-23501327
[Presentation] 転写因子LMO1の標的遺伝子同定による新たな神経芽腫治療標的分子経路の探索
- Author(s)
  佐伯宣久
- Organizer
  第118回日本小児科学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2015-04-17 – 2015-04-19
- Data Source
  KAKENHI-PROJECT-26670510
[Presentation] 膵管がんで発現が誘導されるPSCA遺伝子は正常膵臓のランゲルハンス島で発現している.
- Author(s)
  小野弘恵、坂本裕美、吉田輝彦、佐伯宣久
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23501327
[Presentation] 一塩基多型rs2294008のTアレルは転写因子YY1を介して、がん抑制機能を持つPSCA遺伝子の発現を抑制し、胃がん易罹患性の原因となる
- Author(s)
  佐伯宣久、小野弘恵、青柳一彦、佐々木博己、柳原五吉、坂本裕美、吉田輝彦
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-23501327

1. SASAKI Hiroki (60235265)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results

SAEKI Norihisa 佐伯 宣久

佐伯 宣久 サエキ ノリヒサ

Research Projects

Research Products

Co-Researchers

Exploration of microRNA regulated by LMO1, a neuroblastoma oncogenePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of vector specific to diffuse-type gastric cancer cells for peritoneal metastasis control

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of PSCA, a gastric cancer susceptibility genePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Prostate stem cell antigen and pancreatic cancer. In: Endocrine disease.2014

Author(s)

Publisher

Data Source

[Book] Prostate stem cell antigen and pancreatic cancer. In: Endocrine disease.2014

Author(s)

Total Pages

Publisher

Data Source

[Book] Gasdermin superfamily : a novel gene family fuctioning in epithelial cells. In Endothelium and Epithelium : Composition and Functions. (Carrasco J and Mota M (edits))2012

Author(s)

Publisher

Data Source

[Journal Article] Tumor suppressive let-7 family microRNAs are indirectly down-regulated by LMO1 in neuroblastoma.2016

Author(s)

Journal Title

Data Source

[Journal Article] Chromatin immunoprecipitation and DNA sequencing identified a LIMS1/ILK pathway regulated by an oncogenic transcription factor LMO1 in neuroblastoma.2016

Author(s)

Journal Title

Data Source

[Journal Article] Down-regulation of immune-related genes by PSCA in gallbladder cancer cells implanted into mice.2015

Author(s)

Journal Title

Data Source

[Journal Article] rs2294008 T, a risk allele for gastric and gallbladder cancers, suppresses a PSCA promoter by recruiting a transcription factor YY1.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Missense allele of a single nucleotide polymorphism rs2294008 attenuated anti-tumor effects of prostate stem cell antigen (PSCA) in gallbladder cancer cells.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Five gastric cancer-susceptibility loci identified by genome-wide association studies.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genetic factors related to gastric cancer susceptibility identified using a genome-wide association study.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prostate stem cell antigen gene is expressed in islets of pancreas.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chromosome 1q22 is a susceptibility locus of diffuse-type gastric cancer, harboring a functional SNP of MUC12011

Author(s)

Journal Title

Data Source

[Presentation] 神経芽腫において転写調節因子LMO1が制御する分子経路2016

Author(s)

Organizer

SAEKI Norihisa 佐伯宣久

佐伯宣久サエキノリヒサ