Okura Tsuyoshi 大倉毅

Researcher Number	80510073
Other IDs	https://orcid.org/0000-0003-3713-6617
Affiliation (Current)	2024: 鳥取大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2018 – 2023: 鳥取大学, 医学部, 講師 2014 – 2017: 鳥取大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 52010:General internal medicine-related / Laboratory medicine / Metabolomics Except Principal Investigator Basic Section 48030:Pharmacology-related
Keywords	Principal Investigator 糖尿病 / インスリン抵抗性 / エキソソーム / 2型糖尿病 / エクソソーム / インスリン抵抗性指標 / グルコースクランプ Except Principal Investigator 髄鞘 / 視床下部 / レプチン / 肥満

視床下部髄鞘異常による肥満でのレプチン抵抗性発症の機序と肥満病態への寄与の解明
- Principal Investigator
  
  市原克則
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Tottori University
エクソソーム解析によるインスリン抵抗性の分子病態の解明Principal Investigator
- Principal Investigator
  
  大倉毅
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Tottori University
Research for the novel therapeutic target of insulin resistance and type 2 diabetes by analyzing of exosomePrincipal Investigator
- Principal Investigator
  
  OKURA Tsuyoshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Tottori University
Research for the molecular mechanism of insulin resistance in the Japanese and American by analyzing of exosomePrincipal Investigator
- Principal Investigator
  
  OKURA Tsuyoshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Tottori University
Development of a novel insulin resistance index that is minimally affected by hepatic insulin clearancePrincipal Investigator
- Principal Investigator
  
  OKURA Tsuyoshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Tottori University
a novel insulin resistance index for the patients with type 2 diabetesPrincipal Investigator
- Principal Investigator
  
  Okura Tsuyoshi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Tottori University

All 2024 2023 2022 2020 2018 2017 2016 2015 Other

All Journal Article Presentation

[Journal Article] Presurgery health influences outcomes following vertical sleeve gastrectomy in adolescents2024
- Author(s)
  Swertfeger Debi、Kim Ahlee、Sexmith Hannah、Moreno‐Fernandez Maria E.、Davidson W. Sean、Helmrath Michael、Jenkins Todd、Okura Tsuyoshi、Geh Esmond、Xanthakos Stavra A.、Szabo Sara、Nakamura Takahisa、Divanovic Senad、Shah Amy Sanghavi
- Journal Title
  
  Obesity
  
  Volume: 32 Issue: 6 Pages: 1-11
- DOI
  10.1002/oby.24018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07443
[Journal Article] Aldehyde dehydrogenase 2 polymorphism is an important gene for insulin resistance in Japanese patients with type 2 diabetes.2023
- Author(s)
  Okura T, Nakamura R, Anno M, Ito Y, Kitao S, Endo S, Taneda N, Matsumoto K, Shoji K, Okura H, Matsuzawa K, Izawa S, Ueta E, Kato M, Imamura T, Taniguchi SI, Yamamoto K.
- Journal Title
  
  Metabol Open.
  
  Volume: 18 Pages: 100242-100242
- DOI
  10.1016/j.metop.2023.100242
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03378, KAKENHI-PROJECT-22K07443
[Journal Article] Fasting hepatic insulin clearance reflects postprandial hepatic insulin clearance: a brief report2023
- Author(s)
  Okura Tsuyoshi、Nakamura Risa、Kitao Sonoko、Ito Yuichi、Anno Mari、Matsumoto Kazuhisa、Shoji Kyoko、Matsuzawa Kazuhiko、Izawa Shoichiro、Okura Hiroko、Ueta Etsuko、Kato Masahiko、Imamura Takeshi、Taniguchi Shin-ichi、Yamamoto Kazuhiro
- Journal Title
  
  Diabetology & Metabolic Syndrome
  
  Volume: 15 Issue: 1 Pages: 01241-4
- DOI
  10.1186/s13098-023-01241-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07443
[Journal Article] Significance of pancreatic duodenal homeobox-1 (PDX-1) genetic polymorphism in insulin secretion in Japanese patients with type 2 diabetes2022
- Author(s)
  Okura Tsuyoshi、Nakamura Risa、Ito Yuichi、Kitao Sonoko、Anno Mari、Endo Satomi、Taneda Natsuka、Matsumoto Kazuhisa、Shoji Kyoko、Okura Hiroko、Matsuzawa Kazuhiko、Izawa Shoichiro、Ueta Etsuko、Kato Masahiko、Imamura Takeshi、Taniguchi Shin-ichi、Yamamoto Kazuhiro
- Journal Title
  
  BMJ Open Diabetes Research and Care
  
  Volume: 10 Issue: 5 Pages: e002908-e002908
- DOI
  10.1136/bmjdrc-2022-002908
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07443, KAKENHI-PROJECT-19H03378
[Journal Article] Hepatic insulin clearance is increased in patients with high HbA1c type 2 diabetes: a preliminary report2020
- Author(s)
  Okura Tsuyoshi、Fujioka Yohei、Nakamura Risa、Anno Mari、Ito Yuichi、Kitao Sonoko、Matsumoto Kazuhisa、Shoji Kyoko、Sumi Keisuke、Matsuzawa Kazuhiko、Izawa Shoichiro、Okura Hiroko、Ueta Etsuko、Noma Hisashi、Kato Masahiko、Imamura Takeshi、Taniguchi Shin-Ichi、Yamamoto Kazuhiro
- Journal Title
  
  BMJ Open Diabetes Research & Care
  
  Volume: 8 Issue: 1 Pages: e001149-e001149
- DOI
  10.1136/bmjdrc-2019-001149
- NAID
  120007146973
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07913, KAKENHI-PROJECT-19KK0402, KAKENHI-PROJECT-17K00753
[Journal Article] CPR-IR is an insulin resistance index that is minimally affected by hepatic insulin clearance?A preliminary research2018
- Author(s)
  Okura Tsuyoshi、Nakamura Risa、Fujioka Yohei、Kawamoto-Kitao Sonoko、Ito Yuichi、Matsumoto Kazuhisa、Shoji Kyoko、Sumi Keisuke、Matsuzawa Kazuhiko、Izawa Shoichiro、Ueta Etsuko、Kato Masahiko、Imamura Takeshi、Taniguchi Shin-ichi、Yamamoto Kazuhiro
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Issue: 5 Pages: 0197663-0197663
- DOI
  10.1371/journal.pone.0197663
- NAID
  120007146977
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08935
[Journal Article] Body mass index ?23 is a risk factor for insulin resistance and diabetes in Japanese people: A brief report2018
- Author(s)
  Okura Tsuyoshi、Nakamura Risa、Fujioka Yohei、Kawamoto-Kitao Sonoko、Ito Yuichi、Matsumoto Kazuhisa、Shoji Kyoko、Sumi Keisuke、Matsuzawa Kazuhiko、Izawa Shoichiro、Ueta Etsuko、Kato Masahiko、Imamura Takeshi、Taniguchi Shin-ichi、Yamamoto Kazuhiro
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Issue: 7 Pages: 0201052-0201052
- DOI
  10.1371/journal.pone.0201052
- NAID
  120007146974
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08935
[Journal Article] グルコースクランプ法を用いた新規インスリン抵抗性指標の開発2018
- Author(s)
  大倉毅
- Journal Title
  
  Bio Clinica
  
  Volume: 31 Pages: 466-468
- Data Source
  KAKENHI-PROJECT-16K08935
[Journal Article] 肝インスリン分解の影響を受けにくい新規インスリン抵抗性指標CPR‐IRの開発2018
- Author(s)
  大倉毅
- Journal Title
  
  Bio Clinica
  
  Volume: 33
- Data Source
  KAKENHI-PROJECT-16K08935
[Journal Article] Serum fatty acid-binding protein 4 (FABP4) concentration is associated with insulin resistance in peripheral tissues, A clinical study.2017
- Author(s)
  Nakamura R, Okura T, Fujioka Y, Sumi K, Matsuzawa K, Izawa S, Ueta E, Kato M, Taniguchi SI, Yamamoto K.
- Journal Title
  
  PLoS One
  
  Volume: 12 Issue: 6 Pages: e0179737-e0179737
- DOI
  10.1371/journal.pone.0179737
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08935
[Journal Article] High serum advanced glycation end products are associated with decreased insulin secretion in patients with type 2 diabetes2017
- Author(s)
  Tsuyoshi Okura, Etsuko Ueta, Risa Nakamura, Yohei Fujioka, Keisuke Sumi, Kazuhisa matsumoto, Kyoko Shoji, Kazuhiko Matsuzawa, Shoichiro Izawa, Yuri Nomi, Hitomi Mihara, Yuzuru Otsuka, Masahiko Kato, Shin-ichi Taniguchi, Kazuhiro Yamamoto
- Journal Title
  
  Journal of Diabetes Research
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K08935
[Journal Article] High Serum Advanced Glycation End Products Are Associated with Decreased Insulin Secretion in Patients with Type 2 Diabetes: A Brief Report2017
- Author(s)
  Okura Tsuyoshi、Ueta Etsuko、Nakamura Risa、Fujioka Yohei、Sumi Keisuke、Matsumoto Kazuhisa、Shoji Kyoko、Matsuzawa Kazuhiko、Izawa Shoichiro、Nomi Yuri、Mihara Hitomi、Otsuka Yuzuru、Kato Masahiko、Taniguchi Shin-ichi、Yamamoto Kazuhiro
- Journal Title
  
  Journal of Diabetes Research
  
  Volume: 2017 Pages: 1-7
- DOI
  10.1155/2017/5139750
- NAID
  120007146981
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K00892, KAKENHI-PROJECT-16K08935, KAKENHI-PROJECT-15K16195
[Journal Article] 2型糖尿病における新規インスリン抵抗性指標の開発2016
- Author(s)
  大倉　毅
- Journal Title
  
  BIO Clinica
  
  Volume: 31 Pages: 87-89
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K08935
[Presentation] SGLT2阻害薬の食後インスリン動態、インスリン抵抗性に与える影響の検証2023
- Author(s)
  大倉毅、北尾苑子、伊藤祐一、阿武茉利、市原克則、今村武史、山本一博
- Organizer
  第44回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-22K06860
[Presentation] 日本人2型糖尿病のインスリン分泌・抵抗性に関与する因子の検討2023
- Author(s)
  9.大倉毅, 北尾苑子, 伊藤祐一, 阿武茉利, 中村理沙, 上田悦子, 今村武史, 谷口晋一, 山本一博
- Organizer
  第66回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-22K07443
[Presentation] 肝インスリン分解に影響する因子の検討2018
- Author(s)
  大倉毅、藤岡洋平、中村理沙、谷口晋一、山本一博
- Organizer
  第5回肝臓と糖尿病・代謝研究会
- Data Source
  KAKENHI-PROJECT-16K08935
[Presentation] Hepatic Insulin Clearance Is Increased in the Patients with Poorly Controlled Type 2 Diabetes2018
- Author(s)
  Okura T, Annno M, Ito Y
- Organizer
  American Diabetes Association 78th Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08935
[Presentation] 肝インスリン分解の影響を受けにくい血中Cペプチドを用いた新規インスリン抵抗性指標の開発2016
- Author(s)
  大倉毅, 藤岡洋平, 中西理沙, 角　啓佑, 松本　和久，庄司恭子, 松澤和彦, 伊澤正一郎, 加藤雅彦, 谷口晋一, 山本一博
- Organizer
  第59回日本糖尿病学会年次学術集会
- Place of Presentation
  国立京都国際会館(京都府京都市)
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-16K08935
[Presentation] 20/(fasting C-peptide × fasting plasma glucose) is a novel index of insulin resistance with small effect of hepatic insulin clearance2015
- Author(s)
  Tsuyoshi Okura
- Organizer
  American Diabetes Association 75th Scientific Sessions
- Place of Presentation
  Boston Convention and Exhibition Center(アメリカ、ボストン)
- Year and Date
  2015-06-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26870373
[Presentation] グルコースクランプ試験結果推定式，新規インスリン抵抗性指標1080/（空腹時Cペプチド×空腹時血糖）の開発2015
- Author(s)
  大倉毅
- Organizer
  第112 回日本内科学会講演会
- Place of Presentation
  みやこめっせ(京都市)
- Year and Date
  2015-04-10
- Data Source
  KAKENHI-PROJECT-26870373
[Presentation] 肝インスリン代謝の影響の少ない新規インスリン抵抗性指標の開発2015
- Author(s)
  大倉毅
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  海峡メッセ下関(下関市)
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26870373
[Presentation] 肝インスリン代謝の影響の少ない新規インスリン抵抗性指標の開発
- Author(s)
  大倉　毅
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  東京第一ホテル下関(下関市)
- Year and Date
  2015-05-21 – 2015-05-23
- Data Source
  KAKENHI-PROJECT-26870373
[Presentation] 20/(fasting C-peptide × fasting plasma glucose) is a novel index of insulin resistance with small effect of hepatic insulin clearance
- Author(s)
  Tsuyoshi Okura
- Organizer
  American Diabetes Association’s 75th Scientific Sessions
- Place of Presentation
  Boston, Massachusetts, USA
- Year and Date
  2015-06-05 – 2015-06-09
- Data Source
  KAKENHI-PROJECT-26870373

1. 藤岡洋平 (10791048)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
2. NAKAMURA Risa

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
3. 市原克則 (50710711)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 長田佳子 (50304209)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SUMI keisuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. UETA Etsuko

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. IMAMURA Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. OTSUKA Yuzuru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. NOMI Yuri

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. MIHARA Hitomi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 伊藤靖

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Okura Tsuyoshi 大倉 毅

Research Projects

Research Products

Co-Researchers

視床下部髄鞘異常による肥満でのレプチン抵抗性発症の機序と肥満病態への寄与の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

エクソソーム解析によるインスリン抵抗性の分子病態の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research for the novel therapeutic target of insulin resistance and type 2 diabetes by analyzing of exosomePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research for the molecular mechanism of insulin resistance in the Japanese and American by analyzing of exosomePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a novel insulin resistance index that is minimally affected by hepatic insulin clearancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

a novel insulin resistance index for the patients with type 2 diabetesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Presurgery health influences outcomes following vertical sleeve gastrectomy in adolescents2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Aldehyde dehydrogenase 2 polymorphism is an important gene for insulin resistance in Japanese patients with type 2 diabetes.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fasting hepatic insulin clearance reflects postprandial hepatic insulin clearance: a brief report2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Significance of pancreatic duodenal homeobox-1 (PDX-1) genetic polymorphism in insulin secretion in Japanese patients with type 2 diabetes2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hepatic insulin clearance is increased in patients with high HbA1c type 2 diabetes: a preliminary report2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] CPR-IR is an insulin resistance index that is minimally affected by hepatic insulin clearance?A preliminary research2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Body mass index ?23 is a risk factor for insulin resistance and diabetes in Japanese people: A brief report2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] グルコースクランプ法を用いた新規インスリン抵抗性指標の開発2018

Author(s)

Okura Tsuyoshi 大倉毅