Aoki Kazuhiro 青木一洋

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AOKI Kazuhiro 青木一洋

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Researcher Number	80511427
Other IDs	https://orcid.org/0000-0001-7263-1555
Affiliation (Current)	2025: 京都大学, 生命科学研究科, 教授
Affiliation (based on the past Project Information) *help	2024 – 2025: 京都大学, 生命科学研究科, 教授 2023: 大学共同利用機関法人自然科学研究機構(機構直轄研究施設), 生命創成探究センター, 教授 2018 – 2022: 大学共同利用機関法人自然科学研究機構(新分野創成センター、アストロバイオロジーセンター、生命創成探究, 生命創成探究センター, 教授 2016 – 2017: 大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 岡崎統合バイオサイエンスセンター, 教授 2015: 京都大学, 大学院医学研究科, 准教授 … More 2013 – 2015: 京都大学, 医学(系)研究科(研究院), 准教授 2010 – 2012: 京都大学, 生命科学研究科, 講師 2011: 京都大学, 大学院・生命科学研究科, 講師 2009: Kyoto University, 大学院・生命科学研究科, 助教 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Complex systems / Basic Section 44010:Cell biology-related / Transformative Research Areas, Section (IV) / Medium-sized Section 44:Biology at cellular to organismal levels, and related fields / Transformative Research Areas, Section (III) / Constructive Systems Biology / Tumor therapeutics / Tumor biology / General medical chemistry … More Except Principal Investigator … More Transformative Research Areas, Section (IV) / Basic Section 62010:Life, health and medical informatics-related / Basic Section 43040:Biophysics-related / Complex systems / Biological Sciences Less
Keywords	Principal Investigator ERK / FRET / シミュレーション / イメージング / 光遺伝学 / Akt / FRETイメージング / シグナル伝達 / 細胞周期 / PhyB … More / PIF / Phytochrome / BRaf / KRas / PI3K / Ras / 解離定数 / FCCS / パラメーター / 味覚受容体 / 細胞内シグナル伝達系 / GPCR / 蛍光バイオセンサー / 成長因子 / AKT / タイトジャンクション / ZO-1 / 細胞競合 / 1分子イメージング / 細胞内情報伝達 / 情報理論 / １分子イメージング / EGF / 走化性 / 細胞性粘菌 / EGFR / 情報量 / CDK / サイクリン / G1/S / G1-S期チェックポイント / RB / チェックポイント / 分裂酵母 / 線虫 / optogenetics / 遺伝子編集 / Intrinsic resistance / Oncogene addiction / intrinsic resistance / oncogene addiction / 細胞間伝搬 / 集団運動 / collective migration / 細胞集団運動 / Optogenetics / レポーター / 数理モデル / 内因的抵抗性 / 組換え / レトロウイルス / レンチウイルス / 定量 / FCS / オプトジェネティクス / フィードバック / mTOR / 分子標的薬 / リン酸化 / 癌 / システム生物学 … More Except Principal Investigator 生物物理学 / 計算論的生物学 / 複雑系生物学 / 進化生物学 / システム生物学 / 数理モデル / 機械学習 / 数理モデリング / データ駆動生物学 / Global BioImaging (GBI) / 科研費課題 / 科研費取得者 / 支援活動 / トレーニング / 画像解析 / 磁気共鳴画像 / 電子顕微鏡 / 光学顕微鏡 / 画像解析支援 / 磁気共鳴画像支援 / 電子顕微鏡支援 / 光学顕微鏡支援 / バイオイメージング / 数理生物学 / 構造理論 / 数理解析 / ダイナミクス / チェックポイント制御 / 分岐解析 / 感度解析 / ネットワーク / 恒常性 / 細胞周期 / 構造分岐解析 / 構造感度解析 / 数理理論 / 制御ネットワーク / 反応ネットワーク / 情報熱力学 / 非平衡統計力学 / 情報物理学 / 脳腫瘍 / MDCK細胞 / Cdc42 / FRETバイオセンサー / 二光子顕微鏡 / Rac1 / トランスジェニックマウス / 神経発生 / 蛍光イメージング / 生体イメージング / 蛍光共鳴エネルギー移動 / FRET / FRETイメージング / バイオセンサー / 蛍光タンパク質 / フレットイメージング / 二光子イメージング / がん Less

EPIC Assembly: Emergence of novel functional assembly by Evo-Physico Information Coupling
- Principal Investigator
  
  小林徹也
- Project Period (FY)
  2025 – 2029
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (IV)
- Research Institution
  The University of Tokyo
Elucidation of the physical and evolutionary rules of heterotypic circuit assembly in intracellular signaling and chemosensory systemsPrincipal Investigator
- Principal Investigator
  
  青木一洋
- Project Period (FY)
  2025 – 2029
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (IV)
- Research Institution
  Kyoto University
Mechanisms of cancer cell elimination by remodeling of cell adhesion moleculesPrincipal Investigator
- Principal Investigator
  
  青木一洋
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Kyoto University
成長因子バイオセンサーの開発と生体内での成長因子の可視化Principal Investigator
- Principal Investigator
  
  青木一洋
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
- Research Institution
  Kyoto University
Advanced Bioimaging Support
- Principal Investigator
  
  伊佐正, 鍋倉淳一
- Project Period (FY)
  2022 – 2027
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (platforms for Advanced Technologies and Research Resources)
- Research Institution
  National Institute for Physiological Sciences
Gating mechanism of ERK and AKT in cell cycle checkpointPrincipal Investigator
- Principal Investigator
  
  青木一洋
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Kyoto University
  National Institutes of Natural Sciences
Data-driven identification of governing equations for multicellular dynamics
- Principal Investigator
  
  本田直樹
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 62010:Life, health and medical informatics-related
- Research Institution
  Hiroshima University
Understanding of cell signaling with information physicsPrincipal Investigator
- Principal Investigator
  
  Aoki Kazuhiro
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  National Institutes of Natural Sciences
Information physics of living matters
- Principal Investigator
  
  岡田康志
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  The University of Tokyo
Mathematical study for homeostasis in living systems based on network structure
- Principal Investigator
  
  Mochizuki Atsushi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  Kyoto University
Development of optogenetic tools for manipulation of cellular function by genetically encoded PhyB-PIF systemPrincipal Investigator
- Principal Investigator
  
  青木一洋
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  Center for Novel Science Initatives, National Institutes of Natural Sciences
Quantitative understanding of the mechanism of G1-S phase checkpoint regulated by ERK signalPrincipal Investigator
- Principal Investigator
  
  AOKI Kazuhiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Center for Novel Science Initatives, National Institutes of Natural Sciences
遺伝子にコードされたPhyB-PIF系を用いた細胞機能の光制御技術の開発Principal Investigator
- Principal Investigator
  
  青木一洋
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Okazaki Research Facilities, National Institutes of Natural Sciences
ERK活性伝播による３次元形態形成制御の構成的理解Principal Investigator
- Principal Investigator
  
  青木一洋
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Okazaki Research Facilities, National Institutes of Natural Sciences
癌細胞の脆弱性と頑強性の構成的理解Principal Investigator
- Principal Investigator
  
  青木一洋
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Constructive Systems Biology
- Research Institution
  Center for Novel Science Initatives, National Institutes of Natural Sciences
  Okazaki Research Facilities, National Institutes of Natural Sciences
Systems analysis of intrinsic resistance to MEK inhibitor in KRas- or BRaf-mutataed cancer cellsPrincipal Investigator
- Principal Investigator
  
  AOKI Kazuhiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Okazaki Research Facilities, National Institutes of Natural Sciences
  Kyoto University
ERK経路の多細胞動態と細胞増殖制御の解明Principal Investigator
- Principal Investigator
  
  青木一洋
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
反応速度論的パラメーター測定のためのイメージング基盤技術構築Principal Investigator
- Principal Investigator
  
  青木一洋
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Kyoto University
生体イメージングによる反応速度論的パラメーターの高感度計測Principal Investigator
- Principal Investigator
  
  青木一洋
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Kyoto University
Systematic analysis of Ras/ERK pathway with FRET imagingPrincipal Investigator
- Principal Investigator
  
  AOKI Kazuhiro
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Kyoto University
Multidimendional FRET imaging of intracellular signal transduction
- Principal Investigator
  
  Matsuda Michiyuki
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Analysis of mechanisms of ERK MAP kinase phosphorylationPrincipal Investigator
- Principal Investigator
  
  AOKI Kazuhiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University

[Book] バイオ画像解析　手とり足とり2014
- Author(s)
  小林徹也、青木一洋
- Total Pages
  220
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-26290053
[Journal Article] Longitudinal reduction in brain volume in patients with schizophrenia and its association with cognitive function2024
- Author(s)
  Yamazaki R, Matsumoto J, Ito S, Nemoto K, Fukunaga M, Hashimoto N, Kodaka F, Takano H, Hasegawa N, Yasuda Y, Fujimoto M, Yamamori H, Watanabe Y, Miura K, Hashimoto R
- Journal Title
  
  Neuropsychopharmacology Reports
  
  Volume: 44 Issue: 1 Pages: 206-215
- DOI
  10.1002/npr2.12423
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06920, KAKENHI-PROJECT-20K07945, KAKENHI-PROJECT-21K12153, KAKENHI-PROJECT-19H05467, KAKENHI-PROJECT-22H04926
[Journal Article] Live-cell imaging defines a threshold in CDK activity at the G2/M transition2024
- Author(s)
  Sugiyama Hironori、Goto Yuhei、Kondo Yohei、Coudreuse Damien、Aoki Kazuhiro
- Journal Title
  
  Developmental Cell
  
  Volume: 59 Issue: 4 Pages: 545-557.e4
- DOI
  10.1016/j.devcel.2023.12.014
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15115, KAKENHI-PROJECT-22KJ3189, KAKENHI-PLANNED-19H05798
[Journal Article] Identification of the growth cone as a probe and driver of neuronal migration in the injured brain2024
- Author(s)
  Nakajima C、Sawada M、Umeda E、Takagi Y、Nakashima N、Kuboyama K、Kaneko N、Yamamoto S、Nakamura H、Shimada N、Nakamura K、Matsuno K、Uesugi S、Veprek NA、Kuellmer F、Nasufovic V、Uchiyama H、Nakada M、Otsuka Y、Ito Y、Herranz-Perez V、Garcia-Verdugo JM、Ohno N、Arndt H-D、Trauner D、Tabata Y、Igarashi M、Sawamoto K
- Journal Title
  
  Nature Communications
  
  Volume: 15 Issue: 1 Pages: 1877-1877
- DOI
  10.1038/s41467-024-45825-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K19406, KAKENHI-PROJECT-23K05770, KAKENHI-PROJECT-21K06395, KAKENHI-PLANNED-21H05106, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-20H05700, KAKENHI-PROJECT-23K27270
[Journal Article] Increased Parenchymal Free Water May Be Decreased by Revascularization Surgery in Patients with Moyamoya Disease2024
- Author(s)
  Hara Shoko、Hori Masaaki、Kamagata Koji、Andica Christina、Inaji Motoki、Tanaka Yoji、Aoki Shigeki、Nariai Tadashi、Maehara Taketoshi
- Journal Title
  
  MRMS
  
  Volume: 23 Issue: 4 Pages: 405-416
- DOI
  10.2463/mrms.mp.2022-0146
- ISSN
  1347-3182, 1880-2206
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18406, KAKENHI-PROJECT-22H04926
[Journal Article] Noise reduction by multiple path neural network using Attention mechanisms with an emphasis on robustness against Errors: A pilot study on brain Diffusion-Weighted images2023
- Author(s)
  Tachibana Yasuhiko、Otsuka Yujiro、Nozaki Hayato、Kamagata Koji、Mori Shinichiro、Saito Yuya、Aoki Shigeki
- Journal Title
  
  Physica Medica
  
  Volume: 116 Pages: 103176-103176
- DOI
  10.1016/j.ejmp.2023.103176
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07096, KAKENHI-PROJECT-22H04926
[Journal Article] Decoding cellular deformation from pseudo-simultaneously observed Rho GTPase activities2023
- Author(s)
  Katsuyuki Kunida Nobuhiro Takagi Kazuhiro Aoki Kazushi Ikeda Takeshi Nakamura Yuichi Sakumura
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 2 Pages: 1-16
- DOI
  10.1016/j.celrep.2023.112071
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H04283, KAKENHI-PROJECT-20K06880, KAKENHI-PROJECT-19K20400, KAKENHI-PROJECT-23K23888, KAKENHI-ORGANIZER-19H05794, KAKENHI-PLANNED-19H05798
[Journal Article] Comprehensive and quantitative analysis of intracellular structure polarization at the apical?basal axis in elongating Arabidopsis zygotes2023
- Author(s)
  Hiromoto Yukiko、Minamino Naoki、Kikuchi Suzuka、Kimata Yusuke、Matsumoto Hikari、Nakagawa Sakumi、Ueda Minako、Higaki Takumi
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 22879-22879
- DOI
  10.1038/s41598-023-50020-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15135, KAKENHI-PROJECT-23K14204, KAKENHI-PLANNED-19H05676, KAKENHI-PROJECT-22H04926
[Journal Article] Glymphatic system impairment in corticobasal syndrome: diffusion tensor image analysis along the perivascular space (DTI-ALPS).2023
- Author(s)
  Saito Y, Kamagata K, Andica C, Uchida W, Takabayashi K, Yoshida S, Nakaya M, Tanaka Y, Kamio S, Sato K, Nishizawa M, Akashi T, Shimoji K, Wada A, Aoki S.
- Journal Title
  
  Japanese journal of radiology.
  
  Volume: Nov;41(11) Issue: 11 Pages: 1226-1235
- DOI
  10.1007/s11604-023-01454-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07690, KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-23K27556
[Journal Article] Reproducibility of automated calculation technique for diffusion tensor image analysis along the perivascular space2023
- Author(s)
  Saito Yuya、Kamagata Koji、Andica Christina、Uchida Wataru、Takabayashi Kaito、Yoshida Seina、Nakaya Moto、Tanaka Yuya、Kamiyo Satoru、Sato Kanako、Nishizawa Mitsuo、Akashi Toshiaki、Shimoji Keigo、Wada Akihiko、Aoki Shigeki
- Journal Title
  
  Japanese Journal of Radiology
  
  Volume: － Issue: 9 Pages: 947-954
- DOI
  10.1007/s11604-023-01415-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07690, KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-23K27556
[Journal Article] Glymphatic system impairment in sleep disruption: diffusion tensor image analysis along the perivascular space (DTI-ALPS)2023
- Author(s)
  Saito Y, Hayakawa Y(equal contribution), Kamagata K, Kikuta J, Mita T, Andica C, Taoka T, Uchida W, Takabayashi K, Tuerxun R, Mahemuti Z, Yoshida S, Kitagawa T, Arai T, Suzuki A, Sato K, Nishizawa M, Akashi T, Shimoji K, Wada A, Aoki S
- Journal Title
  
  Japanese Journal of Radiology
  
  Volume: 41 Issue: 12 Pages: 1335-1343
- DOI
  10.1007/s11604-023-01463-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15833, KAKENHI-PROJECT-21K07690, KAKENHI-PROJECT-21K07563, KAKENHI-PROJECT-20K16737, KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-23K27556
[Journal Article] Development of a chub mackerel with less-aggressive fry stage by genome editing of arginine vasotocin receptor V1a22023
- Author(s)
  Ohga Hirofumi、Shibata Koki、Sakanoue Ryo、Ogawa Takuma、Kitano Hajime、Kai Satoshi、Ohta Kohei、Nagano Naoki、Nagasako Tomoya、Uchida Seiichi、Sakuma Tetsushi、Yamamoto Takashi、Kim Sangwan、Tashiro Kosuke、Kuhara Satoru、Gen Koichiro、Fujiwara Atushi、Kazeto Yukinori、Kobayashi Takanori、Matsuyama Michiya
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 3190-3190
- DOI
  10.1038/s41598-023-30259-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06137, KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-19H00951
[Journal Article] Cerebral cortical structural alteration patterns across four major psychiatric disorders in 5549 individuals.2023
- Author(s)
  J. Matsumoto，M. Fukunaga，K. Miura，K. Nemoto K，N. Okada, et al.
- Journal Title
  
  Mol Psychiatry
  
  Volume: 28 Issue: 11 Pages: 4915-4923
- DOI
  10.1038/s41380-023-02224-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18419, KAKENHI-PROJECT-20KK0193, KAKENHI-PROJECT-21K07498, KAKENHI-PROJECT-22K07617, KAKENHI-PROJECT-23K07001, KAKENHI-PROJECT-23K07015, KAKENHI-PROJECT-20K06920, KAKENHI-PROJECT-20K07945, KAKENHI-PROJECT-21K12153, KAKENHI-PROJECT-21K13727, KAKENHI-PROJECT-19H05467, KAKENHI-PLANNED-21H05174, KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-19H00630, KAKENHI-PROJECT-20H03598, KAKENHI-PROJECT-23K21414
[Journal Article] Optimal inference of molecular interaction dynamics in FRET microscopy2023
- Author(s)
  Kamino Keita、Kadakia Nirag、Avgidis Fotios、Liu Zhe-Xuan、Aoki Kazuhiro、Shimizu Thomas、Emonet Thierry
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 120 Issue: 15
- DOI
  10.1073/pnas.2211807120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-19H05798
[Journal Article] Subcortical volumetric alterations in four major psychiatric disorders: a mega-analysis study of 5604 subjects and a volumetric data-driven approach for classification.2023
- Author(s)
  N. Okada，et al.
- Journal Title
  
  Mol Psychiatry.
  
  Volume: 28 Issue: 12 Pages: 5206-5216
- DOI
  10.1038/s41380-023-02141-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18419, KAKENHI-PROJECT-20KK0193, KAKENHI-PROJECT-21K07498, KAKENHI-PROJECT-22K07617, KAKENHI-PROJECT-23K07001, KAKENHI-PROJECT-23K07015, KAKENHI-PROJECT-20K06920, KAKENHI-PROJECT-20K07945, KAKENHI-PROJECT-21K12153, KAKENHI-PROJECT-18K15478, KAKENHI-PROJECT-21K13727, KAKENHI-PROJECT-20H03605, KAKENHI-PROJECT-19H05467, KAKENHI-PLANNED-21H05174, KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-19H00630, KAKENHI-PROJECT-20H03598, KAKENHI-PROJECT-23K21414
[Journal Article] Chemogenetic Manipulation of Endogenous Proteins in Fission Yeast Using a Self-Localizing Ligand-Induced Protein Translocation System2023
- Author(s)
  Nakamura Akinobu、Goto Yuhei、Sugiyama Hironori、Tsukiji Shinya、Aoki Kazuhiro
- Journal Title
  
  ACS Chemical Biology
  
  Volume: 18 Issue: 12 Pages: 2506-2515
- DOI
  10.1021/acschembio.3c00478
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15115, KAKENHI-PROJECT-22KJ3189, KAKENHI-PLANNED-19H05798
[Journal Article] In vivo expression vector derived from anhydrobiotic tardigrade genome enables live imaging in Eutardigrada2023
- Author(s)
  Tanaka Sae、Aoki Kazuhiro、Arakawa Kazuharu
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 120 Issue: 5
- DOI
  10.1073/pnas.2216739120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19302, KAKENHI-PLANNED-21H05279, KAKENHI-PROJECT-23K23888, KAKENHI-ORGANIZER-19H05794, KAKENHI-PLANNED-19H05798
[Journal Article] Traveling Subject-Informed Harmonization Increases Reliability of Brain Diffusion Tensor and Neurite Mapping2023
- Author(s)
  Saito Yuya、Kamagata Koji、Andica Christina、Maikusa Norihide、Uchida Wataru、Takabayashi Kaito、Yoshida Seina、Hagiwara Akifumi、Fujita Shohei、Akashi Toshiaki、Wada Akihiko、Irie Ryusuke、Shimoji Keigo、Hori Masaaki、Kamiya Kouhei、Koike Shinsuke、Hayashi Takuya、Aoki Shigeki
- Journal Title
  
  Aging and Disease
  
  Volume: Online ahead of print Pages: 1-16
- DOI
  10.14336/ad.2023.1020
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0193, KAKENHI-PROJECT-21K07690, KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-23K21414, KAKENHI-PROJECT-23K27556
[Journal Article] Optical Control of Cell Signaling with Red/Far-Red Light-Responsive Optogenetic Tools in Caenorhabditis elegans2023
- Author(s)
  Oda Shigekazu、Sato-Ebine Emi、Nakamura Akinobu、Kimura Koutarou D.、Aoki Kazuhiro
- Journal Title
  
  ACS Synthetic Biology
  
  Volume: 12 Issue: 3 Pages: 700-708
- DOI
  10.1021/acssynbio.2c00461
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22KK0100, KAKENHI-PLANNED-21H05299, KAKENHI-PROJECT-23K21325, KAKENHI-PROJECT-23K23888, KAKENHI-ORGANIZER-19H05794, KAKENHI-PLANNED-19H05798
[Journal Article] A transcriptional program underlying the circannual rhythms of gonadal development in medaka2023
- Author(s)
  Nakayama Tomoya、Tanikawa Miki、Okushi Yuki、Itoh Thoma、Shimmura Tsuyoshi、Maruyama Michiyo、Yamaguchi Taiki、Matsumiya Akiko、Shinomiya Ai、Guh Ying-Jey、Chen Junfeng、Naruse Kiyoshi、Kudoh Hiroshi、Kondo Yohei、Naoki Honda、Aoki Kazuhiro、Nagano Atsushi J.、Yoshimura Takashi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 120 Issue: 52 Pages: 120-120
- DOI
  10.1073/pnas.2313514120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23KJ1009, KAKENHI-PROJECT-20K20459, KAKENHI-PROJECT-20K15840, KAKENHI-PROJECT-21H04977, KAKENHI-PLANNED-19H05798, KAKENHI-PROJECT-19H05643
[Journal Article] Multisite harmonization of diffusion tensor image analysis along the perivascular space using the COMBined Association Test2023
- Author(s)
  Saito Yuya、Kamagata Koji、Andica Christina、Taoka Toshiaki、Tuerxun Rukeye、Uchida Wataru、Takabayashi Kaito、Owaki Mana、Yoshida Seina、Yamazaki Keigo、Naganawa Shinji、Aoki Shigeki
- Journal Title
  
  Japanese Journal of Radiology
  
  Volume: - Issue: 10 Pages: 1072-1083
- DOI
  10.1007/s11604-023-01432-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17244, KAKENHI-PROJECT-21K07563, KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-23K27556
[Journal Article] A mechanism with severing near barbed ends and annealing explains structure and dynamics of dendritic actin networks2022
- Author(s)
  Holz Danielle、Hall Aaron R、Usukura Eiji、Yamashiro Sawako、Watanabe Naoki、Vavylonis Dimitrios
- Journal Title
  
  eLife
  
  Volume: 11
- DOI
  10.7554/elife.69031
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06150, KAKENHI-PUBLICLY-21H05780, KAKENHI-PROJECT-22H00456, KAKENHI-PUBLICLY-22H04843, KAKENHI-ORGANIZER-19H05794
[Journal Article] Quantitative live-cell imaging of GPCR downstream signaling dynamics2022
- Author(s)
  Tany Ryosuke、Goto Yuhei、Kondo Yohei、Aoki Kazuhiro
- Journal Title
  
  Biochemical Journal
  
  Volume: 479 Issue: 8 Pages: 883-900
- DOI
  10.1042/bcj20220021
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-19H05670, KAKENHI-PLANNED-19H05675, KAKENHI-ORGANIZER-19H05794, KAKENHI-PLANNED-19H05798
[Journal Article] Association of MRI Indices of Glymphatic System With Amyloid Deposition and Cognition in Mild Cognitive Impairment and Alzheimer Disease2022
- Author(s)
  Kamagata Koji、Andica Christina、Takabayashi Kaito、Saito Yuya、Taoka Toshiaki、Nozaki Hayato、Kikuta Junko、Fujita Shohei、Hagiwara Akifumi、Kamiya Kouhei、Wada Akihiko、Akashi Toshiaki、Sano Katsuhiro、Nishizawa Mitsuo、Hori Masaaki、Naganawa Shinji、Aoki Shigeki、for the Alzheimer's Disease Neuroimaging Initiative
- Journal Title
  
  Neurology
  
  Volume: 99 Issue: 24
- DOI
  10.1212/wnl.0000000000201300
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07563, KAKENHI-PROJECT-20K16737, KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-19K17244
[Journal Article] Microstructural white matter abnormalities in multiple sclerosis and neuromyelitis optica spectrum disorders: Evaluation by advanced diffusion imaging2022
- Author(s)
  Kato Shimpei、Hagiwara Akifumi、Yokoyama Kazumasa、Andica Christina、Tomizawa Yuji、Hoshino Yasunobu、Uchida Wataru、Nishimura Yuma、Fujita Shohei、Kamagata Koji、Hori Masaaki、Hattori Nobutaka、Abe Osamu、Aoki Shigeki
- Journal Title
  
  Journal of the Neurological Sciences
  
  Volume: 436 Pages: 120205-120205
- DOI
  10.1016/j.jns.2022.120205
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20F20113, KAKENHI-PROJECT-22H04926
[Journal Article] A chemogenetic platform for controlling plasma membrane signaling and synthetic signal oscillation2022
- Author(s)
  Sachio Suzuki†, Akinobu Nakamura†, Yuka Hatano, Masaru Yoshikawa, Tatsuyuki Yoshii, Shunsuke Sawada, Kyoko Atsuta-Tsunoda, Kazuhiro Aoki, Shinya Tsukiji
- Journal Title
  
  Cell Chemical Biology
  
  Volume: 29 Issue: 9 Pages: 1446-1464
- DOI
  10.1016/j.chembiol.2022.06.005
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21H05226, KAKENHI-PLANNED-19H05798
[Journal Article] Computer-aided detection of quantitative signatures for breast fibroepithelial tumors using label-free multi-photon imaging2022
- Author(s)
  Kobayashi-Taguchi Kana、Saitou Takashi、Kamei Yoshiaki、Murakami Akari、Nishiyama Kanako、Aoki Reina、Kusakabe Erina、Noda Haruna、Yamashita Michiko、Kitazawa Riko、Imamura Takeshi、Takada Yasutsugu
- Journal Title
  
  Molecules
  
  Volume: 27 Issue: 10 Pages: 3340-3340
- DOI
  10.3390/molecules27103340
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-21H03056
[Journal Article] A feedback loop between lamellipodial extension and HGF-ERK signaling specifies leader cells during collective cell migration2022
- Author(s)
  Hino Naoya、Matsuda Kimiya、Jikko Yuya、Maryu Gembu、Sakai Katsuya、Imamura Ryu、Tsukiji Shinya、Aoki Kazuhiro、Terai Kenta、Hirashima Tsuyoshi、Trepat Xavier、Matsuda Michiyuki
- Journal Title
  
  Developmental Cell
  
  Volume: 57 Issue: 19 Pages: 2290-2304
- DOI
  10.1016/j.devcel.2022.09.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H00993, KAKENHI-PROJECT-20K06553, KAKENHI-PROJECT-23K21377, KAKENHI-PROJECT-23K23888, KAKENHI-ORGANIZER-19H05794, KAKENHI-PLANNED-19H05798, KAKENHI-PLANNED-20H05898
[Journal Article] Control cell migration by engineering integrin ligand assembly2022
- Author(s)
  Hu Xunwu、Roy Sona Rani、Jin Chengzhi、Li Guanying、Zhang Qizheng、Asano Natsuko、Asahina Shunsuke、Kajiwara Tomoko、Takahara Atsushi、Feng Bolu、Aoki Kazuhiro、Xu Chenjie、Zhang Ye
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 5002-5002
- DOI
  10.1038/s41467-022-32686-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23888, KAKENHI-PLANNED-19H05798
[Journal Article] Comprehensive Volumetric Analysis of Mecp2-Null Mouse Model for Rett Syndrome by T2-Weighted 3D Magnetic Resonance Imaging2022
- Author(s)
  Akaba Yuichi、Shiohama Tadashi、Komaki Yuji、Seki Fumiko、Ortug Alpen、Sawada Daisuke、Uchida Wataru、Kamagata Koji、Shimoji Keigo、Aoki Shigeki、Takahashi Satoru、Suzuki Takeshi、Natsume Jun、Takahashi Emi、Tsujimura Keita
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 16 Pages: 1-13
- DOI
  10.3389/fnins.2022.885335
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16031, KAKENHI-PROJECT-20K08095, KAKENHI-PROJECT-22H04926
[Journal Article] A novel red fluorescence dopamine biosensor selectively detects dopamine in the presence of norepinephrine in vitro2021
- Author(s)
  Nakamoto Chihiro、Goto Yuhei、Tomizawa Yoko、Fukata Yuko、Fukata Masaki、Harpsoe Kasper、Gloriam David E.、Aoki Kazuhiro、Takeuchi Tomonori
- Journal Title
  
  Molecular Brain
  
  Volume: 14 Issue: 1 Pages: 173-173
- DOI
  10.1186/s13041-021-00882-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22439, KAKENHI-PROJECT-19K22548, KAKENHI-PLANNED-19H05798, KAKENHI-PUBLICLY-20H04915, KAKENHI-PROJECT-20H00459, KAKENHI-PROJECT-19H03331, KAKENHI-PROJECT-21K19390
[Journal Article] CDCP1 promotes compensatory renal growth by integrating Src and Met signaling2021
- Author(s)
  Kajiwara Kentaro、Yamano Shotaro、Aoki Kazuhiro、Okuzaki Daisuke、Matsumoto Kunio、Okada Masato
- Journal Title
  
  Life Science Alliance
  
  Volume: 4 Issue: 4 Pages: 202000832-202000832
- DOI
  10.26508/lsa.202000832
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08356, KAKENHI-PUBLICLY-19H04962, KAKENHI-PLANNED-19H05798, KAKENHI-PROJECT-18H02444, KAKENHI-PROJECT-19H03499, KAKENHI-PROJECT-19K07639, KAKENHI-PROJECT-21K18250, KAKENHI-PROJECT-19H03504
[Journal Article] A self-exciting point process to study multicellular spatial signaling patterns2021
- Author(s)
  Verma Archit、Jena Siddhartha G.、Isakov Danielle R.、Aoki Kazuhiro、Toettcher Jared E.、Engelhardt Barbara E.
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 118 Issue: 32
- DOI
  10.1073/pnas.2026123118
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05798
[Journal Article] Near-infrared imaging in fission yeast using a genetically encoded phycocyanobilin biosynthesis system2021
- Author(s)
  Sakai Keiichiro、Kondo Yohei、Fujioka Hiroyoshi、Kamiya Mako、Aoki Kazuhiro、Goto Yuhei
- Journal Title
  
  Journal of Cell Science
  
  Volume: 134 Issue: 24 Pages: 1-15
- DOI
  10.1242/jcs.259315
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16050, KAKENHI-PROJECT-19K16207, KAKENHI-PLANNED-19H05675, KAKENHI-PLANNED-19H05798
[Journal Article] Oncogenic mutation or overexpression of oncogenic KRAS or BRAF is not sufficient to confer oncogene addiction.2021
- Author(s)
  Ito Reina E, Oneyama Chitose, Aoki Kazuhiro
- Journal Title
  
  PLOS ONE
  
  Volume: 16 Issue: 4 Pages: e0249388-e0249388
- DOI
  10.1371/journal.pone.0249388
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-19H05794, KAKENHI-PLANNED-19H05798, KAKENHI-PROJECT-20H03456
[Journal Article] 3DeeCellTracker, a deep learning-based pipeline for segmenting and tracking cells in 3D time lapse images2021
- Author(s)
  Wen Chentao、Miura Takuya、Voleti Venkatakaushik、Yamaguchi Kazushi、Tsutsumi Motosuke、Yamamoto Kei、Otomo Kohei、Fujie Yukako、Teramoto Takayuki、Ishihara Takeshi、Aoki Kazuhiro、Nemoto Tomomi、Hillman Elizabeth MC、Kimura Koutarou D
- Journal Title
  
  eLife
  
  Volume: 10
- DOI
  10.7554/elife.59187
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06591, KAKENHI-PROJECT-19K15406, KAKENHI-INTERNATIONAL-16K21735, KAKENHI-ORGANIZER-16H06535, KAKENHI-PLANNED-19H05798, KAKENHI-PROJECT-20H05700, KAKENHI-PROJECT-18H02444, KAKENHI-PROJECT-19J20538, KAKENHI-PLANNED-16H06545, KAKENHI-ORGANIZER-19H05794, KAKENHI-PROJECT-20H05669, KAKENHI-PROJECT-19H03326, KAKENHI-PROJECT-17H06113
[Journal Article] Optogenetic relaxation of actomyosin contractility uncovers mechanistic roles of cortical tension during cytokinesis2021
- Author(s)
  Yamamoto Kei、Miura Haruko、Ishida Motohiko、Mii Yusuke、Kinoshita Noriyuki、Takada Shinji、Ueno Naoto、Sawai Satoshi、Kondo Yohei、Aoki Kazuhiro
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 1-13
- DOI
  10.1038/s41467-021-27458-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16207, KAKENHI-PUBLICLY-19H04797, KAKENHI-PLANNED-19H05675, KAKENHI-PLANNED-19H05801, KAKENHI-PROJECT-18H02454, KAKENHI-PLANNED-19H05798, KAKENHI-PROJECT-19J20538, KAKENHI-PROJECT-18K14720
[Journal Article] Shedding light on developmental ERK signaling with genetically encoded biosensors2021
- Author(s)
  Nakamura Akinobu、Goto Yuhei、Kondo Yohei、Aoki Kazuhiro
- Journal Title
  
  Development
  
  Volume: 148 Issue: 18
- DOI
  10.1242/dev.199767
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19H05798, KAKENHI-PROJECT-19J01341
[Journal Article] Identification of <i>ksg1</i> mutation showing long‐lived phenotype in fission yeast2021
- Author(s)
  Matsui Kotaro、Okamoto Keisuke、Hasegawa Tomoka、Ohtsuka Hokuto、Shimasaki Takafumi、Ihara Kunio、Goto Yuhei、Aoki Kazuhiro、Aiba Hirofumi
- Journal Title
  
  Genes to Cells
  
  Volume: 26 Issue: 12 Pages: 967-978
- DOI
  10.1111/gtc.12897
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06627, KAKENHI-PROJECT-19K15730, KAKENHI-PROJECT-19K16050, KAKENHI-PROJECT-20H02898, KAKENHI-PLANNED-19H05798, KAKENHI-PROJECT-19K06582, KAKENHI-PROJECT-21K05363
[Journal Article] Visualization and Manipulation of Intracellular Signaling2021
- Author(s)
  Goto Yuhei、Kondo Yohei、Aoki Kazuhiro
- Journal Title
  
  Adv Exp Med Biol.
  
  Volume: 1 Pages: 225-234
- DOI
  10.1007/978-981-15-8763-4_13
- ISBN
  9789811587627, 9789811587634
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19H05798, KAKENHI-PROJECT-18H02444, KAKENHI-PLANNED-19H05675, KAKENHI-ORGANIZER-19H05794
[Journal Article] 20 years of Developmental Cell: Looking forward2021
- Author(s)
  Hiiragi Takashi、Gladfelter Amy S.、Miguel-Aliaga Irene、Coller Hilary A.、Lau On Sun、McBride Heidi M.、Aoki Kazuhiro、Linkermann Andreas、Santaguida Stefano、Wasteneys Geoffrey、Rivron Nicolas C.、Shahbazi Marta N.、Ebisuya Miki、Lancaster Madeline A.
- Journal Title
  
  Developmental Cell
  
  Volume: 56 Issue: 23 Pages: 3185-3191
- DOI
  10.1016/j.devcel.2021.11.017
- Data Source
  KAKENHI-PLANNED-19H05798
[Journal Article] Hierarchical modeling of mechano-chemical dynamics of epithelial sheets across cells and tissue2021
- Author(s)
  Asakura Yoshifumi、Kondo Yohei、Aoki Kazuhiro、Naoki Honda
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 4069-4069
- DOI
  10.1038/s41598-021-83396-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-19H05675, KAKENHI-PUBLICLY-19H04776, KAKENHI-PUBLICLY-19H05438, KAKENHI-PLANNED-19H05798, KAKENHI-PROJECT-18H02444, KAKENHI-PROJECT-20J15811, KAKENHI-ORGANIZER-19H05670, KAKENHI-ORGANIZER-19H05794
[Journal Article] Signaling, Deconstructed: Using Optogenetics to Dissect and Direct Information Flow in Biological Systems2021
- Author(s)
  Farahani Payam E.、Reed Ellen H.、Underhill Evan J.、Aoki Kazuhiro、Toettcher Jared E.
- Journal Title
  
  Annual Review of Biomedical Engineering
  
  Volume: 23 Issue: 1 Pages: 61-87
- DOI
  10.1146/annurev-bioeng-083120-111648
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05798, KAKENHI-PROJECT-18H02444
[Journal Article] Desiccation-induced fibrous condensation of CAHS protein from an anhydrobiotic tardigrade2021
- Author(s)
  Yagi-Utsumi Maho、Aoki Kazuhiro、Watanabe Hiroki、Song Chihong、Nishimura Seiji、Satoh Tadashi、Yanaka Saeko、Ganser Christian、Tanaka Sae、Schnapka Vincent、Goh Ean Wai、Furutani Yuji、Murata Kazuyoshi、Uchihashi Takayuki、Arakawa Kazuharu、Kato Koichi
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 21328-21328
- DOI
  10.1038/s41598-021-00724-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15781, KAKENHI-PLANNED-19H05798, KAKENHI-PUBLICLY-20H04669, KAKENHI-PUBLICLY-21H00393, KAKENHI-PLANNED-21H05279, KAKENHI-PROJECT-21H01772
[Journal Article] Redundant roles of EGFR ligands in the ERK activation waves during collective cell migration2021
- Author(s)
  Shuhao Lin, Daiki Hirayama, Gembu Maryu, Kimiya Matsuda, Naoya Hino, Eriko Deguchi, Kazuhiro Aoki, Ryo Iwamoto, Kenta Terai, Michiyuki Matsuda
- Journal Title
  
  Life Science Alliance
  
  Volume: 5 Issue: 1 Pages: 1-13
- DOI
  10.26508/lsa.202101206
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06218, KAKENHI-PLANNED-19H05798, KAKENHI-PROJECT-19H00993, KAKENHI-PROJECT-20H03475, KAKENHI-PLANNED-20H05898, KAKENHI-PROJECT-23K21377
[Journal Article] Engineering orthogonal, plasma membrane-specific SLIPT systems for multiplexed chemical control of signaling pathways in living single cells2020
- Author(s)
  Akinobu Nakamura, Choji Oki, Kenya Kato, Satoko Fujinuma, Gembu Maryu, Keiko Kuwata, Tatsuyuki Yoshii, Michiyuki Matsuda, Kazuhiro Aoki, Shinya Tsukiji
- Journal Title
  
  ACS Chemical Biology
  
  Volume: 15 Issue: 4 Pages: 1004-1015
- DOI
  10.1021/acschembio.0c00024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-18H04546, KAKENHI-PLANNED-19H05798, KAKENHI-PROJECT-18H02086, KAKENHI-PROJECT-18H02444, KAKENHI-PROJECT-19J01341, KAKENHI-PROJECT-19J14793, KAKENHI-PROJECT-19H00993, KAKENHI-ORGANIZER-19H05794
[Journal Article] Improved secretion of glycoproteins using an N-glycan-restricted passport sequence tag recognized by cargo receptor2020
- Author(s)
  Yagi Hirokazu、Yagi-Utsumi Maho、Honda Rena、Ohta Yusaku、Saito Taiki、Nishio Miho、Ninagawa Satoshi、Suzuki Kousuke、Anzai Takahiro、Kamiya Yukiko、Aoki Kazuhiro、Nakanishi Mahito、Satoh Tadashi、Kato Koichi
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 1-9
- DOI
  10.1038/s41467-020-15192-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05798, KAKENHI-PROJECT-18H02444, KAKENHI-PROJECT-19H03361, KAKENHI-PROJECT-16H06280, KAKENHI-PROJECT-18K08443, KAKENHI-ORGANIZER-19H05794, KAKENHI-PROJECT-18K06216, KAKENHI-PLANNED-17H06414
[Journal Article] Improvement of Phycocyanobilin Synthesis for Genetically Encoded Phytochrome-Based Optogenetics2020
- Author(s)
  Uda Youichi、Miura Haruko、Goto Yuhei、Yamamoto Kei、Mii Yusuke、Kondo Yohei、Takada Shinji、Aoki Kazuhiro
- Journal Title
  
  ACS Chemical Biology
  
  Volume: 15 Issue: 11 Pages: 2896-2906
- DOI
  10.1021/acschembio.0c00477
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16050, KAKENHI-PROJECT-18H02454, KAKENHI-PLANNED-19H05798, KAKENHI-PROJECT-18H02444, KAKENHI-PROJECT-19J20538, KAKENHI-ORGANIZER-19H05670, KAKENHI-PLANNED-19H05675, KAKENHI-ORGANIZER-19H05794, KAKENHI-PROJECT-18K14720
[Journal Article] ERK-mediated mechanochemical waves direct collective cell polarization.2020
- Author(s)
  Hino N, Rossetti L, Marin-Llaurad A, Aoki K, Trepat X, Matsuda M, Hirashima T.
- Journal Title
  
  Developmental Cell
  
  Volume: 53 Issue: 6 Pages: 646-660
- DOI
  10.1016/j.devcel.2020.05.011
- NAID
  120006876575
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H00993, KAKENHI-PLANNED-19H05798, KAKENHI-PROJECT-18H02444, KAKENHI-ORGANIZER-19H05794
[Journal Article] A microtubule-LUZP1 association around tight junction promotes epithelial cell apical constriction2020
- Author(s)
  Yano Tomoki、Tsukita Kazuto、Kanoh Hatsuho、Nakayama Shogo、Kashihara Hiroka、Mizuno Tomoaki、Tanaka Hiroo、Matsui Takeshi、Goto Yuhei、Komatsubara Akira、Aoki Kazuhiro、Takahashi Ryosuke、Tamura Atsushi、Tsukita Sachiko
- Journal Title
  
  The EMBO Journal
  
  Volume: 40 Issue: 2
- DOI
  10.15252/embj.2020104712
- URL
  https://localhost/en/publications/5b8a970c-0f27-4635-b2eb-3af07674acb9
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16050, KAKENHI-PLANNED-19H05798, KAKENHI-PROJECT-18H02444, KAKENHI-PROJECT-19H03453, KAKENHI-PROJECT-19K16126, KAKENHI-PROJECT-19H05468, KAKENHI-ORGANIZER-19H05794, KAKENHI-PROJECT-21K15092
[Journal Article] Single-cell quantification of the concentrations and dissociation constants of endogenous proteins2019
- Author(s)
  Akira T Komatsubara, Yuhei Goto, Yohei Kondo, Michiyuki Matsuda, Kazuhiro Aoki
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 294 Issue: 15 Pages: 6062-6072
- DOI
  10.1074/jbc.ra119.007685
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16050, KAKENHI-PUBLICLY-18H04754, KAKENHI-PLANNED-19H05798, KAKENHI-PROJECT-18H02444, KAKENHI-PROJECT-16KT0069, KAKENHI-ORGANIZER-19H05794
[Journal Article] Regulation of cell proliferation and collective cell migration by ERK MAP kinase2019
- Author(s)
  青木一洋
- Journal Title
  
  生化学
  
  Volume: 91 Issue: 1 Pages: 73-80
- DOI
  10.14952/SEIKAGAKU.2019.910073
- NAID
  40021833028
- ISSN
  0037-1017
- Year and Date
  2019-02-25
- Language
  Japanese
- Data Source
  KAKENHI-PUBLICLY-18H04754
[Journal Article] Cell-to-Cell Heterogeneity in p38-Mediated Cross-Inhibition of JNK Causes Stochastic Cell Death2018
- Author(s)
  Miura Haruko、Kondo Yohei、Matsuda Michiyuki、Aoki Kazuhiro
- Journal Title
  
  Cell Reports
  
  Volume: 24 Issue: 10 Pages: 2658-2668
- DOI
  10.1016/j.celrep.2018.08.020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16KT0069, KAKENHI-PUBLICLY-18H04754, KAKENHI-PROJECT-18H02444
[Journal Article] Inverse tissue mechanics of cell monolayer expansion2018
- Author(s)
  Kondo Yohei、Aoki Kazuhiro、Ishii Shin
- Journal Title
  
  PLOS Computational Biology
  
  Volume: 14 Issue: 3 Pages: e1006029-e1006029
- DOI
  10.1371/journal.pcbi.1006029
- NAID
  120006466609
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-18H04754, KAKENHI-PLANNED-17H06310
[Journal Article] Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine2018
- Author(s)
  Muta Yu、Fujita Yoshihisa、Sumiyama Kenta、Sakurai Atsuro、Taketo M. Mark、Chiba Tsutomu、Seno Hiroshi、Aoki Kazuhiro、Matsuda Michiyuki、Imajo Masamichi
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 2174-2174
- DOI
  10.1038/s41467-018-04527-8
- NAID
  120006488609
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0069, KAKENHI-PROJECT-18K06929, KAKENHI-PUBLICLY-18H04754, KAKENHI-PUBLICLY-18H05100, KAKENHI-PROJECT-18H02444, KAKENHI-PLANNED-15H05949, KAKENHI-PROJECT-16H06280, KAKENHI-PROJECT-18H02490
[Journal Article] Live-cell Imaging with Genetically Encoded Protein Kinase Activity Reporters2018
- Author(s)
  Maryu G, Miura H, Uda Y, Komatsubara AT, Matsuda M, Aoki K
- Journal Title
  
  Cell Struct. Funct.
  
  Volume: 43 Issue: 1 Pages: 61-74
- DOI
  10.1247/csf.18003
- NAID
  130006725957
- ISSN
  0386-7196, 1347-3700
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15J08196, KAKENHI-PROJECT-17J08016, KAKENHI-PROJECT-16KT0069, KAKENHI-PUBLICLY-18H04754, KAKENHI-PROJECT-18H02444
[Journal Article] Efficient synthesis of phycocyanobilin in mammalian cells for optogenetic control of cell signaling2017
- Author(s)
  Uda Youichi、Goto Yuhei、Oda Shigekazu、Kohchi Takayuki、Matsuda Michiyuki、Aoki Kazuhiro
- Journal Title
  
  Proc Natl. Acad. Sci. U.S.A.
  
  Volume: 114 Issue: 45 Pages: 11962-11967
- DOI
  10.1073/pnas.1707190114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16KT0069, KAKENHI-PUBLICLY-16H01425, KAKENHI-PUBLICLY-16H01447, KAKENHI-PROJECT-17H07406, KAKENHI-PROJECT-17J06739
[Journal Article] Propagating Wave of ERK Activation Orients Collective Cell Migration2017
- Author(s)
  Aoki Kazuhiro、Kondo Yohei、Naoki Honda、Hiratsuka Toru、Itoh Reina E.、Matsuda Michiyuki
- Journal Title
  
  Developmental Cell
  
  Volume: 43 Issue: 3 Pages: 305-317.e5
- DOI
  10.1016/j.devcel.2017.10.016
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0069, KAKENHI-PROJECT-16K16147, KAKENHI-PUBLICLY-16H01425, KAKENHI-PUBLICLY-16H01447
[Journal Article] Synergistic antitumor effects of combination of PI3K/mTOR and MEK inhibition (SAR245409 and pimasertib) in mucinous ovarian carcinoma cells by fluorescence resonance energy transfer imaging.2016
- Author(s)
  naba K, Oda K, Aoki K, Sone K, Ikeda Y, Miyasaka A, Kashiyama T, Fukuda T, Makii C, Arimoto T, Wada-Hiraike O, Kawana K, Yano T, Osuga Y, Fujii T.
- Journal Title
  
  Oncotarget
  
  Volume: 未定
- NAID
  120005820854
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26290053
[Journal Article] Multiplexed Fluorescence Imaging of ERK and Akt Activities and Cell-cycle Progression2016
- Author(s)
  Maryu G, Matsuda M, Aoki K
- Journal Title
  
  Cell Struct. Funct.
  
  Volume: 41 Issue: 2 Pages: 81-92
- DOI
  10.1247/csf.16007
- NAID
  130005165901
- ISSN
  0386-7196, 1347-3700
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01425, KAKENHI-PUBLICLY-16H01447, KAKENHI-PROJECT-26290053, KAKENHI-PROJECT-16KT0069, KAKENHI-PROJECT-15H02397
[Journal Article] Visualization of Neuregulin 1 ectodomain shedding reveals its local processing in vitro and in vivo.2016
- Author(s)
  Kamezaki A, Sato F, Aoki K, Asakawa K, Kawakami K, Matsuzaki F, Sehara-Fujiwara A.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 28873-28873
- DOI
  10.1038/srep28873
- NAID
  120005819488
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01425, KAKENHI-PUBLICLY-16H01447, KAKENHI-PROJECT-26290053, KAKENHI-PROJECT-16KT0069, KAKENHI-PROJECT-15K11917, KAKENHI-PROJECT-16K07045, KAKENHI-PROJECT-15H02370, KAKENHI-PROJECT-16H04793
[Journal Article] Synergistic antitumor effects of combination of PI3K/mTOR and MEK inhibition (SAR245409 and pimasertib) in mucinous ovarian carcinoma cells by fluorescence resonance energy transfer imaging.2016
- Author(s)
  Inaba K, Oda K, Aoki K, Sone K, Ikeda Y, Miyasaka A, Kashiyama T, Fukuda T, Makii C, Arimoto T, Wada-Hiraike O, Kawana K, Yano T, Osuga Y, Fujii T
- Journal Title
  
  Oncotarget
  
  Volume: 7 Issue: 20 Pages: 29577-29591
- DOI
  10.18632/oncotarget.8807
- NAID
  120005820854
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01425, KAKENHI-PUBLICLY-16H01447, KAKENHI-PROJECT-15H06173, KAKENHI-PROJECT-26290053, KAKENHI-PROJECT-26462515, KAKENHI-PROJECT-16KT0069, KAKENHI-PROJECT-15K10704
[Journal Article] Two New FRET Imaging Measures: Linearly Proportional to and Highly Contrasting the Fraction of Active Molecules.2016
- Author(s)
  Yamao M, Aoki K, Yukinawa N, Ishii S, Matsuda M, Naoki H.
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 10 Pages: e0164254-e0164254
- DOI
  10.1371/journal.pone.0164254
- NAID
  120005853281
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01425, KAKENHI-PUBLICLY-16H01447, KAKENHI-PROJECT-26290053, KAKENHI-PROJECT-16KT0069, KAKENHI-PROJECT-16K16147
[Journal Article] mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cells.2015
- Author(s)
  Komatsu N, Fujita Y, Matsuda M, Aoki K
- Journal Title
  
  Oncogene
  
  Volume: in press Issue: 45 Pages: 5607-5616
- DOI
  10.1038/onc.2015.16
- NAID
  120005712924
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23701052, KAKENHI-PROJECT-26890015, KAKENHI-PROJECT-26290053
[Journal Article] Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin.2015
- Author(s)
  Hiratsuka T, Fujita Y, Naoki H, Aoki K, Kamioka Y, Matsuda M
- Journal Title
  
  eLife
  
  Volume: - Pages: 1-18
- DOI
  10.7554/elife.05178
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-12J04257, KAKENHI-ORGANIZER-22113001, KAKENHI-PUBLICLY-25117715, KAKENHI-PROJECT-25730177, KAKENHI-PROJECT-26290053, KAKENHI-PROJECT-26830070, KAKENHI-PLANNED-22113002, KAKENHI-PLANNED-15H05949
[Journal Article] Fluorescence resonance energy transfer based quantitative analysis of feedforward and feedback loops in epidermal growth factor receptor signaling and the sensitivity to molecular targeting drugs.2014
- Author(s)
  Fujita, Y., Komatsu, N., Matsuda, M., and Aoki, K
- Journal Title
  
  The FEBS journal
  
  Volume: 281 Issue: 14 Pages: 3177-3192
- DOI
  10.1111/febs.12852
- NAID
  120005647503
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22113002, KAKENHI-PROJECT-23701052, KAKENHI-PROJECT-26290053
[Journal Article] Quantitative in vivo fluorescence cross-correlation analyses highlight the importance of competitive effects in the regulation of protein-protein interactions2014
- Author(s)
  Sadaie W, Harada Y, Matsuda M, Aoki K
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 34 Issue: 17 Pages: 3272-3290
- DOI
  10.1128/mcb.00087-14
- NAID
  120005625632
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-25136706, KAKENHI-PUBLICLY-26115708, KAKENHI-PROJECT-26286028, KAKENHI-PROJECT-26290053
[Journal Article] Development of a FRET Biosensor with High Specificity for Akt2014
- Author(s)
  Miura H, Matsuda M, Aoki K.
- Journal Title
  
  Cell Struct. Funct.
  
  Volume: 39 Issue: 1 Pages: 9-20
- DOI
  10.1247/csf.13018
- NAID
  130004137600
- ISSN
  0386-7196, 1347-3700
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701052
[Journal Article] Heterogeneity in ERK activity as visualized by in vivo FRET imaging or mammary tumor cells developed in MMTV-Neu mice.2014
- Author(s)
  Yuka Kumagai, Honda Naoki, Eiji Nakasyo, Yuji Kamioka, Etsuko Kiyokawa, Michiyuki Matsuda
- Journal Title
  
  Oncogene
  
  Volume: (ネット上で先行掲載) Issue: 8 Pages: 1051-7
- DOI
  10.1038/onc.2014.28
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-12J03987, KAKENHI-PROJECT-23701053, KAKENHI-PLANNED-22113002, KAKENHI-PLANNED-15H05949, KAKENHI-ORGANIZER-22113001
[Journal Article] Fluctuation of Rac1 activity is associated with the phenotypic and transcriptional heterogeneity of glioma cells.2014
- Author(s)
  Yukinaga H, Shionyu C, Hirata E, Ui-Tei K, Nagashima T, Kondo S, Okada-Hatakeyama M, Naoki H, Matsuda M.
- Journal Title
  
  J. Cell Sci.
  
  Volume: 127 Issue: 8 Pages: 1805-1815
- DOI
  10.1242/jcs.139733
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-21115004, KAKENHI-PLANNED-22113002, KAKENHI-PUBLICLY-26102713
[Journal Article] A Quantitative Model of ERK MAP Kinase Phosphorylation in Crowded Media2013
- Author(s)
  Aoki, K.
- Journal Title
  
  Scientific Reports
  
  Volume: 3 Issue: 1 Pages: 1541-1541
- DOI
  10.1038/srep01541
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701052
[Journal Article] Stochastic ERK Activation Induced by Noise and Cell-to-Cell Propagation Regulates Cell Density-Dependent Proliferation2013
- Author(s)
  Kazuhiro Aoki, Yuka Kumagai, Atsuro Sakurai, Naoki Komatsu, Yoshihisa Fujita, Clara Shionyu and Michiyuki Matsuda
- Journal Title
  
  Molecular Cell
  
  Volume: 52 Issue: 4 Pages: 529-540
- DOI
  10.1016/j.molcel.2013.09.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J06027, KAKENHI-PROJECT-12J03987, KAKENHI-PROJECT-23701052, KAKENHI-PUBLICLY-25117715
[Journal Article] Fluorescence resonance energy transfer imaging of cell signaling from in vitro to in vivo: Basis of biosensor construction, live imaging, and image processing2013
- Author(s)
  Aoki, K.
- Journal Title
  
  Development Growth and Differentiation
  
  Volume: in press Issue: 4 Pages: 515-522
- DOI
  10.1111/dgd.12039
- NAID
  40019735187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701052, KAKENHI-PROJECT-23701053, KAKENHI-PLANNED-22113002
[Journal Article] Stable expression of FRET biosensors: a new light in cancer research.2012
- Author(s)
  Aoki, K.
- Journal Title
  
  Cancer Science
  
  Volume: 103 Issue: 4 Pages: 614-619
- DOI
  10.1111/j.1349-7006.2011.02196.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701052, KAKENHI-PUBLICLY-23136504
[Journal Article] Development of an optimized backbone of FRET biosensors for kinases and GTPases2011
- Author(s)
  Komatsu N, Aoki K, Yamada M, Yukinaga H, Fujita Y, Kamioka Y, Matsuda M
- Journal Title
  
  Molecular Biology of the Cell
  
  Volume: 22 Pages: 4647-4656
- NAID
  120003644367
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790273
[Journal Article] Processive phosphorylation of ERK MAP kinase in mamalian cells2011
- Author(s)
  K.Aoki, M.Yamada, K.Kunida, S.Yasuda, M.Matsuda
- Journal Title
  
  Proc.Natl.Acad.Sci.USA
  
  Volume: 108 Issue: 31 Pages: 12675-12680
- DOI
  10.1073/pnas.1104030108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J06338, KAKENHI-PROJECT-21790273, KAKENHI-PROJECT-23701052
[Journal Article] Processive phosphorylation of ERK MAP kinase in mammalian cells2011
- Author(s)
  Aoki K, Yamada M, Kunida K, Yasuda S, Matsuda M
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 108 Pages: 12675-12680
- NAID
  120003204017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790273
[Journal Article] Spatiotemporal regulation of small GTPases as revealed by probes based on the principle of Forster Resonance Energy Transfer (FRET): Implications for signaling and pharmacology2011
- Author(s)
  Kiyokawa E, Aoki K, Nakamura T, Matsuda M.
- Journal Title
  
  Annu. Rev. Pharmacol. Toxicol.
  
  Volume: 51 Issue: 1 Pages: 337-58
- DOI
  10.1146/annurev-pharmtox-010510-100234
- Data Source
  KAKENHI-PROJECT-21790273
[Journal Article] Development of an optimized backbone of FRET biosensors for kinases and GTPases2011
- Author(s)
  Komatsu N, Aoki K, Yamada M, Yukinaga H, Fujita Y, Kamioka Y, Matsuda M
- Journal Title
  
  Molecular Biology of the Cell
  
  Volume: 22 Issue: 23 Pages: 4647-4656
- DOI
  10.1091/mbc.e11-01-0072
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J04556, KAKENHI-PROJECT-11J06027, KAKENHI-PROJECT-11J06044, KAKENHI-PROJECT-21790273, KAKENHI-PUBLICLY-23136504, KAKENHI-PROJECT-23701052
[Journal Article] SH3BP1, an Exocyst-Associated RhoGAP, Inactivates Rac1 at the Front to Drive Cell Motility2011
- Author(s)
  M.C.Parrini, A.Sadou-Dubourgnoux, K.Aoki, K.Kunida, M.Biondini, A.Hatzoglou, P.Poullet, E.Formstecher, C.Yeaman, M.Matsuda, C.Rosse, J.Camonis
- Journal Title
  
  Molecular Cell
  
  Volume: 42 Issue: 5 Pages: 650-661
- DOI
  10.1016/j.molcel.2011.03.032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J06338, KAKENHI-ORGANIZER-22113001, KAKENHI-PLANNED-22113002
[Journal Article] The Scaffold Protein Shoc2/SUR-8 Accelerates the Interaction of Ras and Raf.2010
- Author(s)
  Matsunaga-Udagawa R, Fujita Y, Yoshiki S, Terai K, Kamioka Y, Kiyokawa E, Yugi K, ^*Aoki K, Matsuda M.
- Journal Title
  
  The Journal of Biological Chemistry 285
  
  Pages: 7818-7826
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790273
[Journal Article] Multiple decisive phosphorylation sites for the negative feedback regulation of SOS1 via ERK2010
- Author(s)
  Kamioka Y, Yasuda S, Fujita Y, Aoki K, Matsuda M.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 285 Issue: 43 Pages: 33540-33548
- DOI
  10.1074/jbc.m110.135517
- Data Source
  KAKENHI-PROJECT-21790273
[Journal Article] Calcium Signaling Pathways Converge at Raf1 via the Shoc2 Scaffold Protein2010
- Author(s)
  Yoshiki S, Udagawa R, Aoki K, Kamioka Y, Kiyokawa E, Matsuda M. Ras
- Journal Title
  
  Mol. Biol. Cell
  
  Volume: 21 Issue: 6 Pages: 1088-96
- DOI
  10.1091/mbc.e09-06-0455
- Data Source
  KAKENHI-PROJECT-21790273
[Journal Article] Spatiotemporal regulation of small GTPases as revealed by probes based on the principle of Foerster resonance energy transfer (FRET) : Implications for signaling and pharmacology2010
- Author(s)
  E.Kiyokawa, K.Aoki, T.Nakamura, M.Matsuda
- Journal Title
  
  Annu.Rev.Pharmacol.Toxicol.
  
  Volume: 51 Pages: 337-358
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22113002
[Journal Article] Multiple decisive phosphorylation sites for the negative feedback regulation of SOS1 via ERK2010
- Author(s)
  Y.Kamioka, S.Yasuda, Y.Fujita, K.Aoki, M.Matsuda
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 285(43) Pages: 33540-33548
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22113002
[Journal Article] The Scaffold Protein Shoc2/SUR-8 Accelerates the Interaction of Ras and Raf2010
- Author(s)
  Matsunaga-Udagawa R, Fujita Y, Yoshiki S, Terai K, Kamioka Y, Kiyokawa E, Yugi K, Aoki K, Matsuda M.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 285 Issue: 10 Pages: 7818-26
- DOI
  10.1074/jbc.m109.053975
- Data Source
  KAKENHI-PROJECT-21790273
[Journal Article] Signaling Pathways Converge at Raf1 via the Shoc2 Scaffold Protein.2010
- Author(s)
  Yoshiki S, Udagawa R, Aoki K, Kamioka Y, Kiyokawa E, Matsuda M
- Journal Title
  
  Molecular Biology of the Cell 21
  
  Pages: 1088-1096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790273
[Journal Article] Visualization of small GTPase activity with fluorescence resonance energy transfer-based biosensors.2009
- Author(s)
  Aoki K, Matsuda M.
- Journal Title
  
  Nature Protocols 4
  
  Pages: 1623-1631
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790273
[Journal Article] Visualization of small GTPase activity with fluorescence resonance energy transfer-based biosensors2009
- Author(s)
  Aoki K, Matsuda M.
- Journal Title
  
  Nature Protoc.
  
  Volume: 7 Issue: 11 Pages: 1623-31
- DOI
  10.1038/nprot.2009.175
- Data Source
  KAKENHI-PROJECT-21790273
[Presentation] 蛍光イメージングによる細胞周期の定量解析2024
- Author(s)
  青木一洋
- Organizer
  「集え、多分野研究者！」感染症キャンプin 宮崎
- Invited
- Data Source
  KAKENHI-PLANNED-19H05798
[Presentation] Quantitative analysis of mechanical properties and their biological functions using live cell imaging and optogenetics2024
- Author(s)
  Kazuhiro AOKI
- Organizer
  INFORMATION PHYSICS IN LIVING SYSTEMS
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05798
[Presentation] Establishment of a mouse model of Sotos syndrome and its phenotypic analysis2023
- Author(s)
  Higashimoto Ken, Takao Kenzo, Matsuhisa Fumikazu, Yoshioka Yoshichika, Murata Yuzo, Sakumoto Takehisa, Hara Satoshi, Ichimaru Musashi, Yatsuki Hitomi, Kitajima Shuji, Aoki Shigehisa, Yoshiura Koichiro, Soejima Hidenobu
- Organizer
  Human Genetics Asia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H04926
[Presentation] Sotos症候群モデルマウスの樹立と表現型解析2023
- Author(s)
  東元健、高雄啓三、松久葉一、吉岡芳親、村田祐造、佐久本孟寿、原聡史、北嶋修司、青木茂久、吉浦孝一郎、副島英伸
- Organizer
  日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-22H04926
[Presentation] Quantitative analysis of cell cycle by live-cell imaging and optogenetics2023
- Author(s)
  青木一洋
- Organizer
  The 3rd NINS-Princeton Joint Symposium EMERGING LIFE SCIENCES
- Invited
- Data Source
  KAKENHI-ORGANIZER-19H05794
[Presentation] 蛍光プローブと光遺伝学を用いた細胞周期の定量解析2023
- Author(s)
  青木一洋
- Organizer
  イメージングブートキャンプ2022
- Invited
- Data Source
  KAKENHI-ORGANIZER-19H05794
[Presentation] 生細胞イメージングによるGPCRシグナルの動的符号化原理の解明2023
- Author(s)
  青木一洋
- Organizer
  生体機能と創薬シンポジウム2023
- Invited
- Data Source
  KAKENHI-PLANNED-19H05798
[Presentation] ヌクレオポリンの O-GlcNAc 修飾異常を介した腫瘍進展メカニズムの解明2023
- Author(s)
  向井智美、佐藤龍洋、亀井保博、加藤輝、三城恵美、青木正博、藪田紀一、廣島健三、関戸好孝
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22H04926
[Presentation] Live cell imaging of cell signaling and cell fate decision2023
- Author(s)
  Kazuhiro AOKI
- Organizer
  Exploratory Research Center on Life and Living Systems (ExCELLS) and KAIST Sympoisum on Complex Biological Systems (Japan-Korea Collaborative Symposium)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05798
[Presentation] 蛍光プローブと光遺伝学を用いた細胞周期の定量解析2023
- Author(s)
  青木一洋
- Organizer
  イメージングブートキャンプ2022
- Invited
- Data Source
  KAKENHI-PROJECT-23K23888
[Presentation] 蛍光イメージングと光遺伝学による細胞周期の定量解析2023
- Author(s)
  青木一洋
- Organizer
  第32回日本バイオイメージング学会学術集会
- Invited
- Data Source
  KAKENHI-PLANNED-19H05798
[Presentation] 細胞内シグナル伝達系の可視化と光操作2023
- Author(s)
  青木一洋
- Organizer
  EVIDENT Creative Forum 2023 Online 『次世代研究者と語る、これからのライブイメージング - New ERA of Live Cell Imaging with EVIDENT -』
- Invited
- Data Source
  KAKENHI-ORGANIZER-19H05794
[Presentation] Genetically encoded phycocyanobilin synthesis, SynPCB, and its application to optogenetics and live-cell imaging.2023
- Author(s)
  Kazuhiro AOKI
- Organizer
  15th International Conference on Tetrapyrrole Photoreceptors in Photosynthetic Organisms (ICTPPO2023)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05798
[Presentation] 生細胞イメージングと光遺伝学を使った細胞の力学的特性と生物学的機能の解析2023
- Author(s)
  青木一洋
- Organizer
  日本物理学会第78回年次大会
- Invited
- Data Source
  KAKENHI-PLANNED-19H05798
[Presentation] Quantitative analysis of cell cycle by live-cell imaging and optogenetics2023
- Author(s)
  Kazuhiro Aoki
- Organizer
  The 3rd NINS-Princeton Joint Symposium EMERGING LIFE SCIENCES
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23888
[Presentation] 生細胞蛍光イメ―ジングによる可視化と光操作2023
- Author(s)
  青木一洋
- Organizer
  イメージングブートキャンプ2023
- Invited
- Data Source
  KAKENHI-PLANNED-19H05798
[Presentation] ヌクレオポリンの翻訳後修飾異常に着目した、YAP/TAZ の活性化を伴うがんに対する新規治療の可能性2023
- Author(s)
  向井智美、佐藤龍洋、亀井保博、三城恵美、青木正博、藪田紀一、廣島健三、関戸好孝
- Organizer
  第96回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-22H04926
[Presentation] Hippoシグナル系が破綻した中皮腫細胞は過剰なO-GlcNAc 修飾が引き起こされ、核輸送能の亢進による悪性化を引き起こす2023
- Author(s)
  向井智美、佐藤龍洋、三城恵美、青木正博、藪田紀一、廣島健三、関戸好孝
- Organizer
  第4回日本石綿・中皮腫学会学術集会
- Data Source
  KAKENHI-PROJECT-22H04926
[Presentation] Optical control of cell signaling with red/far-red light-responsive optogenetic tools in Caenorhabditis elegans.2022
- Author(s)
  Kazuhiro AOKI
- Organizer
  The 8th IMCR Symposium on Endocrine and Metabolism: Beyond the Frontiers of Endocrinology & Metabolism
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05798
[Presentation] Encoding and Decoding Biological Information2022
- Author(s)
  青木一洋
- Organizer
  第１０回日仏先端科学（JFFoS）シンポジウム
- Invited
- Data Source
  KAKENHI-ORGANIZER-19H05794
[Presentation] Measurement of viscosity of confined in nano-meter gap using combination of micro fluidic device and fluorescence correlation spectroscopy2022
- Author(s)
  Takashima Junpei, Fukuzawa Kenji, Itoh Shintaro, Azuma Naoki, Zhang Hedong
- Organizer
  2022 JSME-IIP/ASME-ISPS Joint Conference on Micromechatronics for Information and Precision Equipment
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H04926
[Presentation] Live-cell imaging illuminates the dynamic encoding of GPCR signaling2022
- Author(s)
  Kazuhiro AOKI
- Organizer
  第45回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PLANNED-19H05798
[Presentation] The role of the transcription factor PITX2c in morphogenesis of the cardiac outflow tract2022
- Author(s)
  Sakaki Shinichiro, Matsuo Kazuhiko, Shigeta Masaki, Saba Rie, Nakajima Nakajima Yoshiro, Kobayahi Daisuke, Inoue Satoshi, Takeshita Naoki, Kamiyama Atsuko, Nishikawa Kosuke, Inuzuka Ryo, Harita Yutaka, Kato Motohiro, Oka Akira, Onodera Hiroshi, Yashiro Kenta
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22H04926
[Presentation] Promotion of sialylation of recombinant glycoprotein by tagging it with a specific sequence recognized by a cargo receptor complex2022
- Author(s)
  Yagi Hirokazu, Yamada Rino, Adachi Shungo, Furukawa Jun-ichi, Saito Taiki, Inutsuka Kengo, Nakano Rio, Yanaka Saeko, Rena Honda, Kazuhiro Aoki, Tojima Takuro, Yagi-Utsumi Maho, Kato Koichi
- Organizer
  Sialoglyco 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H04926
[Presentation] p38を介したJNKの阻害による確率的な細胞死2022
- Author(s)
  青木一洋
- Organizer
  第3回細胞死コロキウム
- Invited
- Data Source
  KAKENHI-ORGANIZER-19H05794
[Presentation] Optical relaxation of actomyosin contractility2022
- Author(s)
  Kazuhiro Aoki
- Organizer
  the 15th Asia Pacific Physics Conference (APPC15)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23888
[Presentation] 生細胞イメージングによって見えてきたGPCR シグナル伝達の動的符号化原理2022
- Author(s)
  青木一洋
- Organizer
  第74回日本細胞生物学会大会
- Invited
- Data Source
  KAKENHI-ORGANIZER-19H05794
[Presentation] Visualization and manipulation of cell cycle regulation by live-cell imaging and optogenetics2022
- Author(s)
  青木一洋
- Organizer
  Cell State Transitions: Approaches, Experimental Systems and Models
- Invited
- Data Source
  KAKENHI-ORGANIZER-19H05794
[Presentation] 生細胞イメージングによって見えてきたGPCR シグナル伝達の動的符号化原理2022
- Author(s)
  青木一洋
- Organizer
  第74回日本細胞生物学会大会
- Invited
- Data Source
  KAKENHI-PLANNED-19H05798
[Presentation] Visualization and manipulation of cell cycle regulation by live-cell imaging and optogenetics2022
- Author(s)
  Kazuhiro AOKI
- Organizer
  Cell State Transitions: Approaches, Experimental Systems and Models
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05798
[Presentation] Optical relaxation of actomyosin contractility2022
- Author(s)
  青木一洋
- Organizer
  the 15th Asia Pacific Physics Conference (APPC15)
- Invited
- Data Source
  KAKENHI-ORGANIZER-19H05794
[Presentation] Optical control of cell signaling with red/far-red light-responsive optogenetic tools in Caenorhabditis elegans.2022
- Author(s)
  青木一洋
- Organizer
  The 8th IMCR Symposium on Endocrine and Metabolism: Beyond the Frontiers of Endocrinology & Metabolism
- Invited
- Data Source
  KAKENHI-ORGANIZER-19H05794
[Presentation] Visualization and manipulation of cell cycle regulation by live-cell imaging and optogenetics2022
- Author(s)
  Kazuhiro Aoki
- Organizer
  Cell State Transitions: Approaches, Experimental Systems and Models
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23888
[Presentation] Live-cell imaging illuminates the dynamic encoding of GPCR signaling2022
- Author(s)
  青木一洋
- Organizer
  第45回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-ORGANIZER-19H05794
[Presentation] Optical control of cell signaling in cultured cells, fission yeast, and worms2021
- Author(s)
  青木一洋
- Organizer
  第59回生物物理学会年会
- Invited
- Data Source
  KAKENHI-PLANNED-19H05798
[Presentation] 光遺伝学を用いた細胞質分裂中の表層張力の機能解析2021
- Author(s)
  青木一洋
- Organizer
  発動分子科学研究会
- Invited
- Data Source
  KAKENHI-PLANNED-19H05798
[Presentation] Optogenetic relaxation of actomyosin contractility uncovers mechanistic roles of cortical tension during cytokinesis2021
- Author(s)
  Kazuhiro Aoki
- Organizer
  European Light Microscopy Initiative 2021 (elmi2021)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05798
[Presentation] 多重蛍光イメージングによって見えてきたGPCR シグナル伝達の動的符号化原理2021
- Author(s)
  青木一洋
- Organizer
  第94回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PLANNED-19H05798
[Presentation] Visualization and manipulation of cell signaling and cell fates.2020
- Author(s)
  青木一洋
- Organizer
  Virtual Workshop: Cell State Transitions: Approaches, Experimental Systems and Models
- Invited
- Data Source
  KAKENHI-ORGANIZER-19H05794
[Presentation] 蛍光イメージングを用いた細胞内シグナル伝達系の可視化・定量化・操作2020
- Author(s)
  青木　一洋
- Organizer
  NCU Life Science Seminar
- Invited
- Data Source
  KAKENHI-PROJECT-18H02444
[Presentation] 蛍光イメージングを用いた細胞内シグナル伝達系の可視化・定量化・操作2020
- Author(s)
  青木　一洋
- Organizer
  NCU Life Science Seminar
- Invited
- Data Source
  KAKENHI-PLANNED-19H05798
[Presentation] メダカ生殖腺に見られる周年リズムの線形回帰解析2020
- Author(s)
  青木一洋
- Organizer
  2020年度日本数理生物学会年会
- Invited
- Data Source
  KAKENHI-ORGANIZER-19H05794
[Presentation] Visualization and manipulation of cell signaling and cell fates.2020
- Author(s)
  Kazuhiro Aoki
- Organizer
  Virtual Workshop: Cell State Transitions: Approaches, Experimental Systems and Models
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05798
[Presentation] 蛍光イメージングを用いた細胞内シグナル伝達系の可視化・定量化・操作2020
- Author(s)
  青木一洋
- Organizer
  NCU Life Science Seminar
- Invited
- Data Source
  KAKENHI-ORGANIZER-19H05794
[Presentation] Visualization and manipulation of cell signaling and cell fates.2020
- Author(s)
  Kazuhiro Aoki
- Organizer
  Virtual Workshop: Cell State Transitions: Approaches, Experimental Systems and Models
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02444
[Presentation] Optogenetics for manipulating cellular functions2020
- Author(s)
  青木一洋
- Organizer
  OIST seminar
- Invited
- Data Source
  KAKENHI-ORGANIZER-19H05794
[Presentation] 細胞内シグナル伝達系の可視化、定量化、光操作2019
- Author(s)
  青木一洋
- Organizer
  大阪大学蛋白質研究所セミナーがん研究の新機軸
- Invited
- Data Source
  KAKENHI-ORGANIZER-19H05794
[Presentation] 生細胞イメージングによる細胞内シグナル伝達系の可視化、定量化、操作2019
- Author(s)
  青木一洋
- Organizer
  第9回光科学異分野横断萌芽研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02444
[Presentation] Visualization and manipulation of cell signaling2019
- Author(s)
  Kazuhiro Aoki
- Organizer
  The 2nd NIBB-Princeton Joint Symposium Imaging and Quantitative Biology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02444
[Presentation] 生細胞イメージングによるJNK活性の細胞間不均一性と確率的な細胞死の可視化2019
- Author(s)
  青木一洋
- Organizer
  第92回日本生化学会大会
- Invited
- Data Source
  KAKENHI-ORGANIZER-19H05794
[Presentation] Live-cell quantification of the concentration and dissociation constant of endogenous proteins by a combination of CRISPR/Cas9 genome editing and FCS/FCCS.2019
- Author(s)
  Kazuhiro Aoki
- Organizer
  Interface between Immunology & Quantitative Biology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05798
[Presentation] 遺伝子技術と生細胞イメージングによる内在性分子濃度と解離定数の定量化2019
- Author(s)
  青木一洋
- Organizer
  第60回日本組織細胞化学会総会・学術集会
- Invited
- Data Source
  KAKENHI-PLANNED-19H05798
[Presentation] Quantification and manipulation of cell signaling by live cell imaging2019
- Author(s)
  青木一洋
- Organizer
  第42回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-ORGANIZER-19H05794
[Presentation] イメージングによる細胞内シグナル伝達の定量化と操作2019
- Author(s)
  青木一洋
- Organizer
  第42回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PLANNED-19H05798
[Presentation] 遺伝子技術と生細胞イメージングによる内在性分子濃度と解離定数の定量化2019
- Author(s)
  青木一洋
- Organizer
  第60回日本組織細胞化学会総会・学術集会
- Invited
- Data Source
  KAKENHI-ORGANIZER-19H05794
[Presentation] Optical Control of Cell Signaling by Genetically Encoded PhyB-PIF System2019
- Author(s)
  青木一洋
- Organizer
  Resonance Bio International Symposium
- Data Source
  KAKENHI-ORGANIZER-19H05794
[Presentation] Optical control of cell signaling in human cells, fission yeast, and worms2019
- Author(s)
  青木一洋
- Organizer
  ICSB2019
- Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-19H05794
[Presentation] 遺伝子技術と生細胞イメージングによる内在性分子濃度と解離定数の定量化2019
- Author(s)
  青木一洋
- Organizer
  第60回日本組織細胞化学会総会・学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02444
[Presentation] Visualization and manipulation of cell signaling2019
- Author(s)
  青木一洋
- Organizer
  The 2nd NIBB-Princeton Joint Symposium Imaging and Quantitative Biology
- Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-19H05794
[Presentation] 細胞内シグナル伝達系の可視化、定量化、光操作2019
- Author(s)
  青木一洋
- Organizer
  大阪大学蛋白質研究所セミナーがん研究の新機軸
- Invited
- Data Source
  KAKENHI-PROJECT-18H02444
[Presentation] 細胞集団運動と非平衡輸送現象の接点2019
- Author(s)
  青木一洋
- Organizer
  定量生物学の会第9回年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04754
[Presentation] 生細胞イメージングによる細胞内シグナル伝達系の可視化、定量化、操作2019
- Author(s)
  青木一洋
- Organizer
  第9回光科学異分野横断萌芽研究会
- Invited
- Data Source
  KAKENHI-PLANNED-19H05798
[Presentation] Live-cell quantification of the concentration and dissociation constant of endogenous proteins by a combination of CRISPR/Cas9 genome editing and FCS/FCCS.2019
- Author(s)
  Kazuhiro Aoki
- Organizer
  Interface between Immunology & Quantitative Biology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02444
[Presentation] Live-cell quantification of endogenous protein interactions by genome editing technique and fluorescence cross-correlation spectroscopy2019
- Author(s)
  青木一洋
- Organizer
  第71回細胞生物学会年次大会
- Data Source
  KAKENHI-ORGANIZER-19H05794
[Presentation] 細胞内シグナル伝達系の可視化・定量化から見えてきた分子夾雑の効果2019
- Author(s)
  青木一洋
- Organizer
  新学術領域「分子夾雑の生命化学」第2回関東シンポジウム
- Invited
- Data Source
  KAKENHI-ORGANIZER-19H05794
[Presentation] イメージングによる細胞内シグナル伝達の定量化と操作2019
- Author(s)
  青木一洋
- Organizer
  第42回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02444
[Presentation] 細胞集団運動と非平衡輸送現象の接点2019
- Author(s)
  青木一洋
- Organizer
  定量生物学の会第9回年会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02444
[Presentation] Visualization and manipulation of cell signaling2019
- Author(s)
  青木一洋
- Organizer
  ExCELLS visit talks at Institute of Biological Chemistry, Academia Sinica
- Invited
- Data Source
  KAKENHI-ORGANIZER-19H05794
[Presentation] Visualization and manipulation of cell signaling2019
- Author(s)
  Kazuhiro Aoki
- Organizer
  The 2nd NIBB-Princeton Joint Symposium Imaging and Quantitative Biology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05798
[Presentation] 細胞内シグナル伝達系の可視化、定量化、光操作2019
- Author(s)
  青木一洋
- Organizer
  大阪大学蛋白質研究所セミナーがん研究の新機軸
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04754
[Presentation] 生細胞イメージングによる細胞内シグナル伝達系の可視化、定量化、操作2019
- Author(s)
  青木一洋
- Organizer
  第9回光科学異分野横断萌芽研究会
- Invited
- Data Source
  KAKENHI-ORGANIZER-19H05794
[Presentation] Live-cell quantification of the concentration and dissociation constant of endogenous proteins by a combination of CRISPR/Cas9 genome editing and FCS/FCCS.2019
- Author(s)
  青木一洋
- Organizer
  Interface between Immunology & Quantitative Biology
- Invited
- Data Source
  KAKENHI-ORGANIZER-19H05794
[Presentation] 細胞内シグナル伝達系の可視化、定量化、光操作2019
- Author(s)
  青木一洋
- Organizer
  大阪大学蛋白質研究所セミナーがん研究の新機軸
- Invited
- Data Source
  KAKENHI-PLANNED-19H05798
[Presentation] 生細胞イメージングによるJNK活性の細胞間不均一性と確率的な細胞死の可視化2019
- Author(s)
  青木一洋
- Organizer
  第92回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02444
[Presentation] 生細胞イメージングによるJNK活性の細胞間不均一性と確率的な細胞死の可視化2019
- Author(s)
  青木一洋
- Organizer
  第92回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PLANNED-19H05798
[Presentation] 実験と数理モデルによる細胞内の情報処理機構の解析2018
- Author(s)
  青木一洋
- Organizer
  第15回生物数学の理論とその応用 -次世代の数理科学への展開-
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04754
[Presentation] 細胞間のERK活性伝搬による細胞集団運動の制御と光操作2018
- Author(s)
  青木一洋
- Organizer
  細胞を創る研究会11.0
- Invited
- Data Source
  KAKENHI-PROJECT-18H02444
[Presentation] 実験と数理モデルによる2018
- Author(s)
  青木一洋
- Organizer
  第15回生物数学の理論とその応用 -次世代の数理科学への展開-
- Invited
- Data Source
  KAKENHI-PROJECT-18H02444
[Presentation] 細胞内シグナル伝達系の可視化と光操作2018
- Author(s)
  青木一洋
- Organizer
  第18回日本蛋白質科学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02444
[Presentation] 細胞内シグナル伝達系の可視化と光操作2018
- Author(s)
  青木一洋
- Organizer
  第18回日本蛋白質科学会年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04754
[Presentation] 細胞間のERK活性伝搬による細胞集団運動の制御と光操作2018
- Author(s)
  青木一洋
- Organizer
  細胞を創る研究会11.0
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04754
[Presentation] Visualization, quantification, and manipulation of cell signaling by imaging.2017
- Author(s)
  Aoki K
- Organizer
  ConBio 2017
- Invited
- Data Source
  KAKENHI-PUBLICLY-16H01425
[Presentation] Visualization, quantification, and manipulation of cell signaling by imaging.2017
- Author(s)
  Aoki K
- Organizer
  ConBio 2017
- Invited
- Data Source
  KAKENHI-PROJECT-16KT0069
[Presentation] Propagation wave of ERK activation orients collective cell migration.2017
- Author(s)
  Aoki K
- Organizer
  50th Annual Meeting of the Japanese Society of Developmental Biologists
- Invited
- Data Source
  KAKENHI-PROJECT-16KT0069
[Presentation] Intercellular propagation of ERK activity orients collective cell migration2017
- Author(s)
  Aoki K
- Organizer
  50th Annual Meeting of the Japanese Society of Developmental Biologists
- Invited
- Data Source
  KAKENHI-PUBLICLY-16H01447
[Presentation] Propagating wave of ERK activation orients collective cell migration2017
- Author(s)
  Aoki K
- Organizer
  ConBio 2017
- Invited
- Data Source
  KAKENHI-PUBLICLY-16H01447
[Presentation] Propagating wave of ERK activation orients collective cell migration2017
- Author(s)
  Kazuhiro Aoki
- Organizer
  FIFTH ANNUAL WINTER Q-BIO MEETING
- Place of Presentation
  Kauai, Hawai, USA
- Year and Date
  2017-02-21
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01447
[Presentation] Propagation wave of ERK activation orients collective cell migration.2017
- Author(s)
  Aoki K
- Organizer
  50th Annual Meeting of the Japanese Society of Developmental Biologists
- Invited
- Data Source
  KAKENHI-PUBLICLY-16H01425
[Presentation] 実験と数理・統計を組み合わせた癌研究2016
- Author(s)
  青木一洋
- Organizer
  第1回肺癌バイオカンファレンス
- Place of Presentation
  日本ベーリンガーインゲルハイム株式会社17FBoadRoom（東京都品川区）
- Invited
- Data Source
  KAKENHI-PROJECT-26290053
[Presentation] Intercellular propagation of ERK activity orients collective cell migration2016
- Author(s)
  Kazuhiro Aoki
- Organizer
  第54回日本生物物理学会年会
- Place of Presentation
  つくば国際会議場, 茨城県、つくば市
- Data Source
  KAKENHI-PUBLICLY-16H01447
[Presentation] Synthetic lethal screening with the MEK inhibitor Trametinib in KRAS-mutant cancer cells2015
- Author(s)
  Aoki K
- Organizer
  第74回日本がん学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-26290053
[Presentation] FRETイメージングによるEGFシグナル伝達系のフィードフォワード・フィードバック経路の定量解析と分子標的薬感受性の予測2014
- Author(s)
  青木　一洋
- Organizer
  第87回日本生化学会年会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2014-10-15
- Data Source
  KAKENHI-PROJECT-26290053
[Presentation] FCCSによるin vivo Kdの定量法の開発2014
- Author(s)
  青木　一洋
- Organizer
  第66回日本細胞生物学会
- Place of Presentation
  奈良県新公会堂
- Year and Date
  2014-06-13
- Invited
- Data Source
  KAKENHI-PROJECT-26290053
[Presentation] FCCSによるin vivo Kdの定量法の開発2014
- Author(s)
  青木　一洋
- Organizer
  第66回日本細胞生物学会
- Place of Presentation
  奈良公会堂
- Year and Date
  2014-06-13
- Invited
- Data Source
  KAKENHI-PUBLICLY-25136706
[Presentation] 画像解析による多細胞動態の解析2014
- Author(s)
  青木　一洋
- Organizer
  第47回日本発生生物学会年会
- Place of Presentation
  ウィンク愛知
- Year and Date
  2014-05-27
- Invited
- Data Source
  KAKENHI-PROJECT-26290053
[Presentation] Toward a quantitative simulation model of Ras-ERK signaling pathway: Quantitative measurement with FCCS and FRET.2013
- Author(s)
  Kazuhiro Aoki
- Organizer
  Quantitative Bioimaging
- Place of Presentation
  Okazaki, Japan
- Year and Date
  2013-03-17
- Invited
- Data Source
  KAKENHI-PUBLICLY-23136504
[Presentation] KRas遺伝子、またはBRaf遺伝子変異陽性がん細胞株の生細胞イメージングによるMEK阻害剤感受性のシステム解析2013
- Author(s)
  青木　一洋、松田　道行
- Organizer
  第72回　日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23701052
[Presentation] Analysis of ERK-induced cell proliferation by FRET imaging.2012
- Author(s)
  Kazuhiro Aoki
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌市、北海道、日本
- Data Source
  KAKENHI-PROJECT-23701052
[Presentation] 分子混み合いの反応速度論的展開と実証2012
- Author(s)
  青木一洋
- Organizer
  定量生物の会第四回年会
- Place of Presentation
  名古屋
- Year and Date
  2012-01-10
- Data Source
  KAKENHI-PROJECT-21790273
[Presentation] FRET imaging reveals a functional link between cell growth and oscillation frequency of ERK activity.2012
- Author(s)
  Kazuhiro Aoki
- Organizer
  Molecular Imaging and Systems Biology(招待講演)
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-23701052
[Presentation] 分子混み合いの反応速度論的展開と実証2012
- Author(s)
  青木一洋
- Organizer
  定量生物の会第四回年会
- Place of Presentation
  名古屋(招待講演)
- Year and Date
  2012-01-10
- Data Source
  KAKENHI-PROJECT-21790273
[Presentation] Stochastic oscillation of ERK MAPK activity induced cell proliferation.2012
- Author(s)
  Kazuhiro Aoki
- Organizer
  International Scientific Coordination Network (ISCN) FRANCE-JAPAN
- Place of Presentation
  Shikoku (Tokushima), Japan
- Invited
- Data Source
  KAKENHI-PROJECT-23701052
[Presentation] 実測パラメーターに基づく細胞内シグナル伝達系の定量的シミュレーション2011
- Author(s)
  青木一洋
- Organizer
  第6回トランスポーター研究会
- Place of Presentation
  宮城県仙台市
- Year and Date
  2011-06-11
- Data Source
  KAKENHI-PROJECT-21790273
[Presentation] がんの制御に向けたシステム的なアプローチ2011
- Author(s)
  青木一洋
- Organizer
  日本のライフ研究開発を元気にする「夢」と「攻め」-バイオ研究と計算・情報科学の次世代型融合を探る-公開シンポジウム
- Place of Presentation
  神戸
- Year and Date
  2011-01-22
- Data Source
  KAKENHI-PROJECT-21790273
[Presentation] FRET imaging revealed a functional link between frequency of ERK oscillation and growth control by cell density2011
- Author(s)
  Aoki K, and Matsuda M
- Organizer
  The 12th International Conference on Systems Biology
- Place of Presentation
  Heidelberg/Mannheim, Germany
- Data Source
  KAKENHI-PROJECT-21790273
[Presentation] 定量的な細胞シグナル伝達モデルの構築にむけて2011
- Author(s)
  青木一洋
- Organizer
  細胞システムの動態と論理
- Place of Presentation
  埼玉県和光市(招待講演)
- Year and Date
  2011-05-24
- Data Source
  KAKENHI-PROJECT-21790273
[Presentation] RETイメージングを用いたERKによる細胞増殖制御機構の解析2011
- Author(s)
  青木一洋、松田道行
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  東京
- Year and Date
  2011-09-21
- Data Source
  KAKENHI-PROJECT-21790273
[Presentation] 実測パラメーターに基づく細胞内シグナル伝達系の定量的シミュレーション2011
- Author(s)
  青木一洋
- Organizer
  第6回トランスポーター研究会
- Place of Presentation
  宮城県仙台市(招待講演)
- Year and Date
  2011-06-11
- Data Source
  KAKENHI-PROJECT-21790273
[Presentation] 定量的な細胞シグナル伝達モデルの構築にむけて2011
- Author(s)
  青木一洋
- Organizer
  細胞システムの動態と論理(招待講演)
- Place of Presentation
  埼玉県和光市
- Data Source
  KAKENHI-PROJECT-23701052
[Presentation] 実測パラメーターに基づく細胞内シグナル伝達系の定量的シミュレーション2011
- Author(s)
  青木一洋
- Organizer
  第６回トランスポーター研究会(招待講演)
- Place of Presentation
  宮城県仙台市
- Data Source
  KAKENHI-PROJECT-23701052
[Presentation] 分子混み合いを加味した反応速度論モデルの構築と実証2011
- Author(s)
  青木一洋
- Organizer
  定量生物の会第三回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21790273
[Presentation] FRETイメージングを用いたERKによる細胞増殖制御機構の解析2011
- Author(s)
  青木一洋、松田道行
- Organizer
  第84回日本生化学会大会(招待講演)
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23701052
[Presentation] FRET imaging revealed a functional link between frequency of ERK oscillation and growth control by cell density.2011
- Author(s)
  Aoki K, and Matsuda M
- Organizer
  The 12th International Conference on Systems Biology,
- Place of Presentation
  Heidelberg/Mannheim, Germany
- Data Source
  KAKENHI-PROJECT-23701052
[Presentation] MAPKシグナル伝達系の定量的数理モデル構築2010
- Author(s)
  青木一洋、松田道行
- Organizer
  定量生物の会第二回年会
- Place of Presentation
  大阪大学(大阪府)
- Year and Date
  2010-01-10
- Data Source
  KAKENHI-PROJECT-21790273
[Presentation] Quantitative kinetic analysis revealed processive phosphorylation of ERK MAP kinase in mammalian cells2010
- Author(s)
  Kazuhiro Aoki, and Michiyuki Matsuda
- Organizer
  第33回日本分子生物学会年会第82回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21790273
[Presentation] 細胞内シグナル伝達系のフィードバック制御による細胞の形態形成機構2009
- Author(s)
  青木一洋、国田勝行、松田道行
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-21790273
[Presentation] Spatio-temporal Regulation of Ras activity by a scaffold protein.2009
- Author(s)
  Aoki K, Matsunaga-Udagawa R, Fujita Y, Yoshiki S, Terai K, Kamioka Y, Kiyokawa K, Matsuda M
- Organizer
  第61回日本細胞生物学会大会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-21790273
[Presentation] Evidence that ERK is processively phosphorylated in mammalian cells.2009
- Author(s)
  Aoki K, Yamada M, Kunida K, Matsuda M
- Organizer
  The 10th International Conference on Systems Biology
- Place of Presentation
  Stanford University, California, USA
- Data Source
  KAKENHI-PROJECT-21790273
[Presentation] Evidence that ERK is processively phosphorylated in mammalian cells2009
- Author(s)
  Aoki K, Yamada M, Kunida K, and Matsuda M
- Organizer
  The 10th International Conference on Systems Biology
- Place of Presentation
  Stanford, California
- Data Source
  KAKENHI-PROJECT-21790273
[Presentation] 細胞内シグナル伝達系のフィードバック制御による細胞の形態形成機構2009
- Author(s)
  青木一洋、国田勝行、松田道行
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸ポートアイランド(兵庫県)
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-21790273
[Presentation] イメージングによる細胞内シグナル伝達系の定量解析
- Author(s)
  青木　一洋
- Organizer
  Research PlaNet 2014
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2014-05-10 – 2014-05-11
- Invited
- Data Source
  KAKENHI-PROJECT-26290053
[Presentation] FRET imaging reveals a functional link between cell growth and oscillation frequency of ERK activity
- Author(s)
  Kazuhiro Aoki
- Organizer
  Molecular Imaging and Systems Biology
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-21790273
[Presentation] イメージングによる細胞内シグナル伝達系と分子標的薬抵抗性の定量解析
- Author(s)
  青木　一洋
- Organizer
  第11回日本病理学会カンファレンス
- Place of Presentation
  六甲山ホテル
- Year and Date
  2014-08-01 – 2014-08-02
- Invited
- Data Source
  KAKENHI-PROJECT-26290053
[Presentation] Imaging and Mathematical Modeling of Molecular Activities in Living Cells
- Author(s)
  Kazuhiro Aoki
- Organizer
  2014 Japan-America Frontiers of Engineering Symposium
- Place of Presentation
  National Museum of Emerging Science and Innovation (Miraikan)
- Year and Date
  2014-06-09 – 2014-06-11
- Invited
- Data Source
  KAKENHI-PROJECT-26290053

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Aoki Kazuhiro 青木 一洋

AOKI Kazuhiro 青木 一洋

Research Projects

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Co-Researchers

EPIC Assembly: Emergence of novel functional assembly by Evo-Physico Information Coupling

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Elucidation of the physical and evolutionary rules of heterotypic circuit assembly in intracellular signaling and chemosensory systemsPrincipal Investigator

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Mechanisms of cancer cell elimination by remodeling of cell adhesion moleculesPrincipal Investigator

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成長因子バイオセンサーの開発と生体内での成長因子の可視化Principal Investigator

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Advanced Bioimaging Support

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Gating mechanism of ERK and AKT in cell cycle checkpointPrincipal Investigator

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Data-driven identification of governing equations for multicellular dynamics

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Understanding of cell signaling with information physicsPrincipal Investigator

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Information physics of living matters

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Mathematical study for homeostasis in living systems based on network structure

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Development of optogenetic tools for manipulation of cellular function by genetically encoded PhyB-PIF systemPrincipal Investigator

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Quantitative understanding of the mechanism of G1-S phase checkpoint regulated by ERK signalPrincipal Investigator

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遺伝子にコードされたPhyB-PIF系を用いた細胞機能の光制御技術の開発Principal Investigator

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Aoki Kazuhiro 青木一洋

AOKI Kazuhiro 青木一洋

[Book] バイオ画像解析　手とり足とり2014