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kuriyama naohisa  栗山 直久

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Kuriyama Naohisa  栗山 直久

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Researcher Number 80525329
Other IDs
Affiliation (Current) 2025: 三重大学, 医学系研究科, 准教授
Affiliation (based on the past Project Information) *help 2025: 三重大学, 医学系研究科, 准教授
2021 – 2023: 三重大学, 医学系研究科, 准教授
2017 – 2018: 三重大学, 医学部附属病院, 講師
2016: 三重大学, 医学系研究科, 講師
2014 – 2015: 三重大学, 医学(系)研究科(研究院), 講師
2013: 三重大学, 医学部附属病院, 助教
Review Section/Research Field
Principal Investigator
Basic Section 55020:Digestive surgery-related / Basic Section 55010:General surgery and pediatric surgery-related / Digestive surgery / General surgery
Keywords
Principal Investigator
肝虚血再灌流障害 / 活性化プロテインC / 虚血再灌流障害 / 凝固Xa因子 / 組織因子 / FXa / エドキサバン / トロンビン / FXa阻害剤 / 血管内皮細胞障害 … More / 抗凝固作用 / 内皮細胞障害 / IRI / endothelial cell injury / hepatic IRI / sphingosine-1-phosphate / activated protein C / PAR-1 / S1PR1 / 虚血再環流障害 / marginal donor graft / 脾臓摘出 / ATP / AMPK / 抗炎症作用 / 脂肪肝 Less
  • Research Projects

    (4 results)
  • Research Products

    (11 results)
  • Co-Researchers

    (7 People)
  •  血管恒常性の制御による肝虚血再灌流障害の抑制メカニズムの解明Principal Investigator

    • Principal Investigator
      栗山 直久
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Mie University
  •  The Significance and Mechanism of TF-FXa-Thrombin Signaling Cascade in Hepatic Ischemia Reperfusion InjuryPrincipal Investigator

    • Principal Investigator
      Kuriyama Naohisa
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Mie University
  •  The impact of PAR-1 and S1PR1 regulation for hepatic ischemia reperfusion injuryPrincipal Investigator

    • Principal Investigator
      Kuriyama Naohisa
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Mie University
  •  Study of expanding indication of marginal donor in living donor liver transplantationPrincipal Investigator

    • Principal Investigator
      Kuriyama Naohisa
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General surgery
    • Research Institution
      Mie University

All 2023 2021 2018 2017

All Journal Article Presentation

  • [Journal Article] The Impact of Dabigatran Treatment on Sinusoidal Protection Against Hepatic Ischemia/Reperfusion Injury in Mice2021

    • Author(s)
      Noguchi Daisuke、Kuriyama Naohisa、Hibi Taemi、Maeda Koki、Shinkai Toru、Gyoten Kazuyuki、Hayasaki Aoi、Fujii Takehiro、Iizawa Yusuke、Tanemura Akihiro、Murata Yasuhiro、Kishiwada Masashi、Sakurai Hiroyuki、Mizuno Shugo
    • Journal Title

      Liver Transplantation

      Volume: 27 Issue: 3 Pages: 1-22

    • DOI

      10.1002/lt.25929

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K17679, KAKENHI-PROJECT-21K08663
  • [Journal Article] Sinusoidal protection by sphingosine-1 phosphate receptor 1 agonist in liver ischemia-reperfusion injury2017

    • Author(s)
      Takahiro Ito, Naohisa Kuriyama, Hiroyuki Kato, Akitoshi Matsuda, Shugo Mizuno, Masanobu Usui, Hiroyuki Sakurai, and Shuji Isaji
    • Journal Title

      Journal of Surgical Research

      Volume: 222 Pages: 139-152

    • DOI

      10.1016/j.jss.2017.09.048

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K10569
  • [Presentation] A Direct Oral Factor Xa Inhibitor Edoxaban Ameriorates Hepatic Ischemia-Reperfusion Injury2023

    • Author(s)
      Koki Maeda, Naohisa Kuriyama, Tatsuya Sakamoto, Benson M Kaluba, Takuya Yuge, Daisuke Noguchi, Takahiro Ito, Kazuyuki Gyoten, Aoi Hayasaki, Takehiro Fujii, Yusuke Iizawa, Yasuhiro Murata, Akihiro Tanemura, Masashi Kishiwada and Shugo
    • Organizer
      American Transplant Congress 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08663
  • [Presentation] FXa inhibitor (Edoxaban tosilate)によるマウス肝虚血再灌流障害の軽減と細胞保護効果2023

    • Author(s)
      前田光貴、栗山直久、伊藤貴洋、尭天一亨、早崎碧泉、藤井武宏、飯澤祐介、村田泰洋、種村彰洋、岸和田昌之、櫻井洋至、水野修吾
    • Organizer
      第122回日本外科学会定期学術集会
    • Data Source
      KAKENHI-PROJECT-21K08663
  • [Presentation] マウス肝虚血再灌流障害におけるprotease activated receptor-1の抑制による肝保護効果2018

    • Author(s)
      野口大介, 栗山直久, 伊藤貴洋, 早崎碧泉, 飯澤祐介, 藤井武宏, 加藤宏之, 種村彰洋, 村田泰洋, 安積良紀, 岸和田昌之, 水野修吾, 臼井正信, 櫻井洋至, 伊佐地秀司
    • Organizer
      第118回日本外科学会定期学術集会
    • Data Source
      KAKENHI-PROJECT-16K10569
  • [Presentation] Selective inhibition of the thrombin receptor protease-activated receptor-1 induces up-regulation of anti-apoptotic protein ERK1/2 against hepatic ischemia-reperfusion injury in mice2018

    • Author(s)
      Daisuke Noguchi, Naohisa Kuriyama, Takahiro Ito, Aoi Hayasaki, Taishiro Takeuchi, Takehiro Fujii, Yusuke Iizawa, Hiroyuki Kato, Akihiro Tanemura, Yasuhiro Murata, Yoshinori Azumi, Masashi Kishiwada, Shugo Mizuno, Masanobu Usui, Hiroyuki Sakurai, Shuji Isaji
    • Organizer
      第30回日本肝胆膵外科学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K10569
  • [Presentation] Selective inhibition of the thrombin receptor protease-activated receptor-1 attenuates hepatic ischemia-reperfusion injury in mice2018

    • Author(s)
      Daisuke Noguchi, Naohisa Kuriyama, Takehiro Fujii, Hiroyuki Kato, Yoshinori Azumi, Masashi Kishiwada, Shugo Mizuno, Masanobu Usui, Hiroyuki Sakurai, Shuji Isaji
    • Organizer
      13th IHPBA World Congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K10569
  • [Presentation] Role of protease activated receptor 1 and sphingosine-1-phospate receptor 1 in mice hepatic ischemia-reperfusion injury for targeting cell signal pathways of activated protein C2017

    • Author(s)
      Takahiro Ito, Naohisa Kuriyama, Hiroyuki Kato, Yusuke Iizawa, Akihiro Tanemura, Yasuhiro Murata, Yoshinori Azumi, Masashi Kishiwada, Shugo Mizuno, Masanobu Usui, Hiroyuki Sakurai, Shuji Isaji
    • Organizer
      2017 American Transplant Congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K10569
  • [Presentation] 肝虚血再灌流障害における類洞内皮保護としてのsphingosine-1-phosphate receptor 1 の役割2017

    • Author(s)
      伊藤貴洋 栗山直久 加藤宏之 早崎碧泉 飯澤祐介 村田泰洋 安積良紀  岸和田昌之 水野修吾 臼井正信 櫻井洋至 伊佐地秀司
    • Organizer
      伊第35回 日本肝移植研究会 (大阪)
    • Data Source
      KAKENHI-PROJECT-16K10569
  • [Presentation] マウス肝虚血再灌流障害におけるprotease-activated receptor 1活性化の細胞保護効果とbiased agonism2017

    • Author(s)
      伊藤貴洋 栗山直久 加藤宏之 村田泰洋 安積良紀 岸和田昌之 水野修吾 臼井正信 櫻井洋至 伊佐地秀司
    • Organizer
      第72回 日本消化器外科学会 (金沢)
    • Data Source
      KAKENHI-PROJECT-16K10569
  • [Presentation] Endothelial sphingosine-1 phosphate receptor 1 mediates protection from early injury after hepatic ischemia-reperfusion injury in a mouse model2017

    • Author(s)
      Takahiro Ito, Naohisa Kuriyama, Hiroyuki Kato, Akitoshi Matsuda, Akihiro Tanemura, Yasuhiro Murata, Yoshinori Azumi, Masashi Kishiwada, Shugo Mizuno, Masanobu Usui, Hiroyuki Sakurai, Shuji Isaji
    • Organizer
      15th Congress of the Asian Society of Transplantation
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K10569
  • 1.  新貝 達 (40860672)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  HIBI Tamami
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  前田 光貴 (00868812)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 4.  FUJII Takehiro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  MATSUDA Akitoshi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  ITO Takahiro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 7.  NOGUCHI Daisuke
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results

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