Yamazaki Yuji 山崎裕自

… Alternative Names

YAMAZAKI Yuji 山崎裕自

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Researcher Number	80527664
Affiliation (Current)	2025: 株式会社関西メディカルネット(関西電力医学研究所), 糖尿病研究センター, 上級特別研究員 2025: 株式会社関西メディカルネット(関西電力医学研究所), 関西電力医学研究所, 客員研究員
Affiliation (based on the past Project Information) *help	2017: 大阪大学, 大学院生命機能研究科/医学系研究科, 准教授 2015: 大阪大学, 生命機能研究科, 助教 2012: 大阪大学, 生命機能/医学, 助教 2011 – 2012: 大阪大学, 生命機能研究科, 准教授 2010: Osaka University, 大学院・生命機能研究科, 助教 2009 – 2010: Osaka University, 生命機能研究科, 助教
Review Section/Research Field	Principal Investigator Cell biology Except Principal Investigator Biological Sciences / Cell biology
Keywords	Principal Investigator アクトミオシン / 細胞間接着 / 細胞・組織 / RhoGEF / 2 / ZO1 / バリアー機能 / 上皮細胞シート / アクトミオシンリング / アドヘレンスジャンクション / ZO-1 / シグナル / タイトジャンクション … More Except Principal Investigator … More バリアー / タイトジャンクション / 細胞骨格 / 生体分子 / 細胞・組織 / Odf2 / アピカル膜 / アペンデージ / 基底小体-中心体系 / シリア・中心体 / 超解像顕微鏡 / 中心体アペンデージ / 気管多繊毛上皮 / アピカル３層構造 / distal appendages / subdistal appendages / Odf2変異マウス / 基底小体 / 中心体 / シリア / 生理学 / シグナル伝達 / アピカル膜複合体 / 水フロー / クローディン / イオン・水フロー / 細胞間接着装置 / 上皮細胞シート / バリア / ノックアウトマウス / クローディ / 細胞間接着装 / プロテオミクス / アドヘレンスジャンクション / 細胞間接着 / 細胞間バリアー / 細胞膜 / プロテオーム / 繊毛 / 細胞接着 / 炎症 / タイトジャンクション(TJ) / 上皮細胞 / 肝臓毛細胆管画分 Less

アクトミオシン骨格の動的運動に連動したタイトジャンクション制御メカニズムの解明Principal Investigator
- Principal Investigator
  
  山崎裕自
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cell biology
- Research Institution
  Osaka University
How reciprocal regulation of the cell-cell adhesion and the apical membrane defines a unified epithelial system via the cytoskeleton and cell signaling in epithelial cell sheets
- Principal Investigator
  
  Tsukita Sachiko
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Cell biology
- Research Institution
  Osaka University
The role of apical cytoskeletons in transition between centrosomes and ciliary basal bodies.
- Principal Investigator
  
  Tsukita Sachiko
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
The analysis of membrane interface in the formation of the cell-cell adhesion complexPrincipal Investigator
- Principal Investigator
  
  YAMAZAKI Yuji
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  Osaka University
A novel approach to cell adhesion/cytoskeleton research for exploring the epithelia cell system
- Principal Investigator
  
  TSUKITA Sachiko
- Project Period (FY)
  2007 – 2012
- Research Category
  
  Grant-in-Aid for Creative Scientific Research
- Research Institution
  Osaka University

All 2016 2015 2014 2012 2011 2010 2009 2008 Other

All Journal Article Presentation Book Other

[Book] Water : The Forgotten Biological Molecule2010
- Author(s)
  Yamazaki, Y., Tamura, A., Tsukita, Sa.
- Publisher
  PanStanford Publish
- Data Source
  KAKENHI-PROJECT-21770209
[Book] Water : The Forgotten Biological Molecule2010
- Author(s)
  Yamazaki, Y., Tamura, A., Tsukita, Sa.
- Publisher
  PanStanford Publish
- Data Source
  KAKENHI-PROJECT-19GS0313
[Book] Water-based biological homeostasis in multiple fluid-compartments in the higher organisms : regulation by the paracellular barrier-forming tight junction of epithelial cell sheets.2010
- Author(s)
  Yamazaki, Y., Tamura, A., Tsukita, S.
- Publisher
  In Water : The Forgotten Biological Molecule PanStanford Publish
- Data Source
  KAKENHI-PROJECT-21770209
[Journal Article] Rho GTP exchange factor ARHGEF11 regulates the integrity of epithelial junctions by connecting ZO-1 and RhoA-myosin II signaling.2012
- Author(s)
  Itoh M, Tsukita S, Yamazaki Y, Sugimoto H.
- Journal Title
  
  Proc Natl Acd Sci USA
  
  Volume: 109 Pages: 9905-9910
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24657134
[Journal Article] EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins.2012
- Author(s)
  Lei Z, Maeda T, Tamura A, Nakamura T, Yamazaki y, Shiratori H, Yashiro K, Tsukita S, Hamada H.
- Journal Title
  
  Developmental Biology
  
  Volume: 371 Pages: 136-145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24657134
[Journal Article] Claudin-based paracellular proton barrier in the stomach.2012
- Author(s)
  Tamura A, Yamazaki Y, Hayashi D, Suzuki K, Sentani K, Yasui W, Tsukita S.
- Journal Title
  
  Ann NY Acd Sci
  
  Volume: 1258 Pages: 108-114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24657134
[Journal Article] Role of claudin species-specific dynamics in reconstitution and remodeling of the zonula occludens2011
- Author(s)
  Yamazaki, Y., Tokumasu, R., Kimura, H., Tsukita, S.
- Journal Title
  
  Mol.Biol.Cell
  
  Volume: 22 Pages: 1495-1504
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19GS0313
[Journal Article] Role of claudin species-specific dynamics in reconstitution and remodeling of the zonula occludens.2011
- Author(s)
  Yamazaki, Y., Tokumasu, R., Kimura, H., Tsukita, S.
- Journal Title
  
  Mol.Biol.Cell
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770209
[Journal Article] Predicted expansion of the claudin multigene family2011
- Author(s)
  Mineta, K., Yamamoto, Y., Yamazaki, Y., Tanaka, H., Tada, Y., Saito, K., Tamura, A., Igarashi, M., Endo, T., Takeuchi, K., Tsukita, Sa.
- Journal Title
  
  FEBS letters
  
  Volume: 585 Pages: 606-612
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19GS0313
[Journal Article] Role of claudin species-specific dynamics in reconstitution and remodeling of the zonula occludens.2011
- Author(s)
  Yamazaki, Y.#, Tokumasu, R#., Kimura, H., Tsukita, S.
- Journal Title
  
  Mol.Biol.Cell 22
  
  Pages: 1495-1504
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770209
[Journal Article] Loss of claudin-15, but not claudin-2, causes Na+ deficiency and glucose malabsorption in mouse small intestine.2011
- Author(s)
  Tamura A, Hayashi H, Imasato M, Yamazaki Y, Hagiwara A, Wada M, Noda T, Watanabe M, Suzuki Y, Tsukita S.
- Journal Title
  
  Gastroenterology
  
  Volume: 140 Pages: 913-923
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770209
[Journal Article] Loss of claudin-15, but not claudin-2, causes Na+ deficiency and Glucose malabsorption in mouse small intestine.2011
- Author(s)
  Tamura, A., Hayashi, H., Imasato, M., Yamazaki, Y., Hagiwara, A., Wada, M., Noda,T., Watanabe, M., Suzuki, Y., Tsukita, S.^*
- Journal Title
  
  Gastroenterology 140
  
  Pages: 913-923
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770209
[Journal Article] Loss of claudin-15, but not claudin-2, causes Na+ deficiency and glucose malabsorption in mouse small intestine2011
- Author(s)
  Tamura A, Hayashi H, Imasato M, Yamazaki Y, Hagiwara A, Wada M, Noda T, Watanabe M, Suzuki Y, Tsukita S
- Journal Title
  
  Gastroenterology
  
  Volume: 140 Pages: 913-923
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19GS0313
[Journal Article] Tara up-regulates E-cadherin transcription by binding to theTrio RhoGEF and inhibiting Rac signaling.2011
- Author(s)
  Yano, T.#, Yamazaki, Y.#, Adachi, M., Okawa, K., Fort, P., Uji, M., Tsukita, S., Tsukita, S.^*
- Journal Title
  
  J.Cell Biol. 193
  
  Pages: 319-332
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770209
[Journal Article] Predicted expansion of the claudin multigene family.2011
- Author(s)
  Mineta, K.^*, Yamamoto, Y., Yamazaki, Y.,Tanaka, H., Tada, Y., Saito, K., Tamura,A, Igarashi, M., Endo, T., Takeuchi, K., Tsukita, S.^*
- Journal Title
  
  FEBS letters 585
  
  Pages: 606-612
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770209
[Journal Article] Tara up-regulates E-cadherin transcription by binding to the Trio RhoGEF and inhibiting Rac signaling.2011
- Author(s)
  Yano, T., Yamazaki, Y., Adachi, M., Okawa, K., Fort, P., Uji, M., Tsukita S. and Tsukita, S
- Journal Title
  
  J. Cell Biol
  
  Volume: 193 Issue: 2 Pages: 319-332
- DOI
  10.1083/jcb.201009100
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19GS0313
[Journal Article] Predicted expansion of the claudin multigene family.2011
- Author(s)
  Mineta, K., Yamamoto, Y., Yamazaki, Y., Tanaka, H., Tada, Y., Saito, K., Tamura, A., Igarashi, M., Endo, T., Takeuchi, K., Tsukita, Sa.
- Journal Title
  
  FEBS letters
  
  Volume: 585 Pages: 606-612
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770209
[Journal Article] Roles of ZO-1 and ZO-2 in establishment of the belt-like adherens and tight junctions with paracellular permselective barrier function.2009
- Author(s)
  Tsukita, S., Katsuno, T., Yamazaki, Y., Umeda, K., Tamura, A., Tsukita, S.
- Journal Title
  
  Ann.N.Y.Acad.Sci. 1165
  
  Pages: 44-52
- Data Source
  KAKENHI-PROJECT-21770209
[Journal Article] Optimized proteomic analysis on gels of cell-cell adhering junctional membrane proteins2008
- Author(s)
  Yamazaki, Y., Okawa, K., Yano, T., Tsukita, Sh., Tsukita, Sa.
- Journal Title
  
  Biochemistry 47
  
  Pages: 5378-5386
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19GS0313
[Journal Article] ZO-1/2-dependent integration of myosin-2 to epithelial zonula adherens2008
- Author(s)
  Yamazaki, Y.
- Journal Title
  
  Mol. Biol. Cell 19
  
  Pages: 3801-3811
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19GS0313
[Journal Article] Tight junction-based epithelial microenvironment and cell proliferation2008
- Author(s)
  Tsukita, Sa, Yamazaki, Y., Katsuno, T., Tamura, A.
- Journal Title
  
  Oncogene 27
  
  Pages: 6930-6938
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19GS0313
[Journal Article] Optimized proteomic analysis on gels of cell-cell Adhering junctional membrane proteins2008
- Author(s)
  Yamazaki, Y.
- Journal Title
  
  Biochemistry 13-47
  
  Pages: 5378-5386
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19GS0313
[Journal Article] ZO-1- and ZO-2- dependent integration of myosin-2 to epithelial zonula adherens2008
- Author(s)
  Yamazaki, Y., Umeda, K., Wada, M., Nada, S., Okada, M., Tsukita, Sh., Tsukita, Sa.
- Journal Title
  
  Mol.Biol.Cell. 19
  
  Pages: 3801-3811
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19GS0313
[Presentation] アトピー性皮膚炎・生体内におけるクローディン1の発現量依存的な機能制御2016
- Author(s)
  徳増玲太郎、山賀康右、山崎裕自、室田浩之、鈴木浩也、田村淳、坂東可菜、古田泰秀、片山一朗、月田早智子
- Organizer
  第39回日本分子生物学会年会
- Data Source
  KAKENHI-PLANNED-24113002
[Presentation] Calmin, a novel AJ components, crosslinks β‐catenin to F‐actin independently of α‐catenin.2015
- Author(s)
  Yano T, Yamazaki Y, Tsukita S.
- Organizer
  ASCB 2015 Annual Meeting,
- Place of Presentation
  San Diego, California, USA
- Year and Date
  2015-12-12
- Data Source
  KAKENHI-PLANNED-24113002
[Presentation] 肝クローディンはマウスの胆汁微小循環と胆石形成姓に影響を与える2014
- Author(s)
  田村淳、松本健吾、今里光伸、田中啓雄、山崎裕自、月田早智子
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-25
- Data Source
  KAKENHI-PLANNED-24113002
[Presentation] AJX-C, a new binding partner of b-catenin, regulate the maintenance of cell-cell adhesion.2014
- Author(s)
  矢野智樹、山崎裕自、月田早智子
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-25
- Data Source
  KAKENHI-PLANNED-24113002
[Presentation] 肝クローディンはマウスの胆汁微小循環と胆石形成姓に影響を与える2014
- Author(s)
  田村淳、松本健吾、今里光伸、田中啓雄、山崎裕自、月田早智子
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-25
- Data Source
  KAKENHI-PROJECT-24247037
[Presentation] Claudin 2 deficiency reduces bile flow and increases susceptibility to cholesterol gallstone disease in mice2014
- Author(s)
  松本健吾、今里光伸、山崎裕自、田中啓雄、渡辺光博、江口英利、永野浩昭、疋田隼人、巽智秀、竹原徹郎、田村淳、月田早智子
- Organizer
  上皮バリア・輸送に関するシンポジウム
- Place of Presentation
  立命館大学BKC ローム記念館（滋賀）
- Year and Date
  2014-11-01
- Data Source
  KAKENHI-PROJECT-24247037
[Presentation] AJX-C, a new binding partner of b-catenin, regulate the maintenance of cell-cell adhesion.2014
- Author(s)
  矢野智樹、山崎裕自、月田早智子
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-25
- Data Source
  KAKENHI-PROJECT-24247037
[Presentation] Claudin 2 deficiency reduces bile flow and increases susceptibility to cholesterol gallstone disease in mice2014
- Author(s)
  松本健吾、今里光伸、山崎裕自、田中啓雄、渡辺光博、江口英利、永野浩昭、疋田隼人、巽智秀、竹原徹郎、田村淳、月田早智子
- Organizer
  上皮バリア・輸送に関するシンポジウム
- Place of Presentation
  立命館大学BKC ローム記念館（滋賀）
- Year and Date
  2014-11-01
- Data Source
  KAKENHI-PLANNED-24113002
[Presentation] The role of claudins in the regulation of liver-biliary system2012
- Author(s)
  Y. Yamazaki, M. Imasato, H. Tanaka, K. Matsumoto, A. Tamura, K. Kunimeta, Mitsuhiro Watanabe, S. Tsukita
- Organizer
  Molecular Structure and Function of the Apical Junctional Complex in Epithelia and Endothelia.
- Place of Presentation
  メキシコ、メリダ
- Data Source
  KAKENHI-PROJECT-24657134
[Presentation] クローディンによるストランド形成のダイナミクス2010
- Author(s)
  山崎裕自
- Organizer
  第62回日本細胞生物学会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-21770209
[Presentation] Novel TBP/Trio/Rac1/p38/Tbx3 cascade regulates E-cadherin expression to fine-tune the epithelial cell sheet2010
- Author(s)
  Yuji Yamazaki
- Organizer
  Membrane dynamics of the cell.
- Place of Presentation
  Heinrich Heine University, Germany
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-21770209
[Presentation] Novel TBP/Trio/Racl/p38/Tbx3 cascade regulates E-cadherin expression to fine-tune the epithelial cell sheet2010
- Author(s)
  山崎裕自
- Organizer
  Membrane dynamics of the cell
- Place of Presentation
  デュッセルドルフ(ドイツ)
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-21770209
[Presentation] クローディンによるストランド形成のダイナミクス2010
- Author(s)
  山崎裕自
- Organizer
  第62回日本細胞生物学会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-21770209
[Presentation] Polymerization of Claudins into Tight Junction Strands2010
- Author(s)
  山崎裕自, 他
- Organizer
  第62回日本細胞生物学会大会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-19GS0313
[Presentation] Roles of ZO1/2 in the Formation of Epithelial Cell-cell Junctions and Paracellular Transport2009
- Author(s)
  Yamazaki, Y., et al.
- Organizer
  The 36th International Congress of Physiological Sciences (IUPS2009)
- Place of Presentation
  京都国際会館
- Year and Date
  2009-07-30
- Data Source
  KAKENHI-PROJECT-21770209
[Presentation] Roles of ZO1/2 in the Formation of Epithelial Cell-cell Junctions and Paracellular Transport2009
- Author(s)
  Yamazaki, Y., et al.
- Organizer
  The 36th International Congress of Physiological Sciences(IUPS2009)
- Place of Presentation
  京都国際会館
- Year and Date
  2009-07-30
- Data Source
  KAKENHI-PROJECT-19GS0313
[Presentation] Roles of ZO1/2 in the Formation of Epithelial Cell-cell Junctions and Paracellular Transport2009
- Author(s)
  Yuji Yamazaki
- Organizer
  IUPS2009
- Place of Presentation
  京都国際会館
- Year and Date
  2009-07-30
- Data Source
  KAKENHI-PROJECT-21770209
[Presentation] 上皮細胞間接着装置の高次構築形成におけるミオシン-2とRho-Aの役割2008
- Author(s)
  山崎裕自
- Organizer
  第31回日本分子生物学会年会
- Place of Presentation
  神戸ポートピアホテル
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-19GS0313
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1. TSUKITA Sachiko (00188517)

# of Collaborated Projects: 3 results

# of Collaborated Products: 16 results
2. TAMURA Atsushi (00362525)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
3. TAKEUCHI Kosei (90206946)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. MATSUI Takeshi (10452442)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SASAKI Hiroyuki (60170693)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Mineta Katsuhiko (40374615)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Ito Masahiko (70270486)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Yamazaki Yuji 山崎 裕自

YAMAZAKI Yuji 山崎 裕自

Research Projects

Research Products

Co-Researchers

アクトミオシン骨格の動的運動に連動したタイトジャンクション制御メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

How reciprocal regulation of the cell-cell adhesion and the apical membrane defines a unified epithelial system via the cytoskeleton and cell signaling in epithelial cell sheets

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of apical cytoskeletons in transition between centrosomes and ciliary basal bodies.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The analysis of membrane interface in the formation of the cell-cell adhesion complexPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A novel approach to cell adhesion/cytoskeleton research for exploring the epithelia cell system

Principal Investigator

Project Period (FY)

Research Category

Research Institution

[Book] Water : The Forgotten Biological Molecule2010

Author(s)

Publisher

Data Source

[Book] Water : The Forgotten Biological Molecule2010

Author(s)

Publisher

Data Source

[Book] Water-based biological homeostasis in multiple fluid-compartments in the higher organisms : regulation by the paracellular barrier-forming tight junction of epithelial cell sheets.2010

Author(s)

Publisher

Data Source

[Journal Article] Rho GTP exchange factor ARHGEF11 regulates the integrity of epithelial junctions by connecting ZO-1 and RhoA-myosin II signaling.2012

Author(s)

Journal Title

Data Source

[Journal Article] EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins.2012

Author(s)

Journal Title

Data Source

[Journal Article] Claudin-based paracellular proton barrier in the stomach.2012

Author(s)

Journal Title

Data Source

[Journal Article] Role of claudin species-specific dynamics in reconstitution and remodeling of the zonula occludens2011

Author(s)

Journal Title

Data Source

[Journal Article] Role of claudin species-specific dynamics in reconstitution and remodeling of the zonula occludens.2011

Author(s)

Journal Title

Data Source

[Journal Article] Predicted expansion of the claudin multigene family2011

Author(s)

Journal Title

Data Source

[Journal Article] Role of claudin species-specific dynamics in reconstitution and remodeling of the zonula occludens.2011

Author(s)

Journal Title

Data Source

[Journal Article] Loss of claudin-15, but not claudin-2, causes Na+ deficiency and glucose malabsorption in mouse small intestine.2011

Author(s)

Journal Title

Data Source

[Journal Article] Loss of claudin-15, but not claudin-2, causes Na+ deficiency and Glucose malabsorption in mouse small intestine.2011

Author(s)

Yamazaki Yuji 山崎裕自

YAMAZAKI Yuji 山崎裕自