Onimaru Manabu 鬼丸学

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ONIMARU Manabu 鬼丸学

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Researcher Number	80529876
Other IDs
Affiliation (Current)	2025: 昭和医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2016 – 2022: 九州大学, 医学研究院, 共同研究員 2013 – 2015: 九州大学, 医学(系)研究科(研究院), 共同研究員 2012: 九州大学, 医学(系)研究科(研究院), 研究員 2011 – 2012: 九州大学, 医学研究院, 共同研究員 2011: 九州大学, 医学(系)研究科(研究院), 共同研究員 2010: 九州大学, 大学院・医学研究院, 共同研究員 2009: 九州大学, 大学病院, 医員
Review Section/Research Field	Principal Investigator Digestive surgery / Basic Section 50020:Tumor diagnostics and therapeutics-related / General surgery Except Principal Investigator Digestive surgery / Basic Section 55020:Digestive surgery-related / Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator 膵癌 / シングルセル解析 / 治療抵抗性 / 免疫逃避機構 / 免疫チェックポイント阻害剤 / CTLA4 / PD-L1 / 免疫チェックポイント / 免疫逃避 / 消化器癌 … More / 免疫細胞 / 癌間質相互作用 / 膵微小環境 / 癌微小環境 / リモデリング / 膵星細胞 / トロンボポエチン / 癌幹細胞 / MYC / ERK / トロンボポエチン(TPO) / CD110 / 肝転移 / CTGF / 低酸素環境 / PDGFRβ / NG2 / 放射線抵抗性 / iRNA / Trichostatin A / Double Strand Break / DNA / HDAC1 / 人工ウイルス … More Except Principal Investigator 膵癌 / 微小環境 / 癌微小環境 / 膵星細胞 / オルガノイド / 局所浸潤 / drug delivery system / 治療抵抗性 / desmoplasia / 人工ウイルス / 新規膵癌治療薬 / 微小環境構成因子 / 癌関連線維芽細胞 / 癌関連脂肪細胞 / 遺伝子変異解析 / 膵臓癌 / リキッドバイオプシー / 次世代シークエンサー / ゲノム不均一性 / シングルセル解析 / 遺伝子変異 / heterogeneity / CTC / KPCマウス / NGS解析 / 次世代シーケンサー / 細胞死形態 / 膵癌オルガノイド / necroptosis / 細胞死 / 膵癌周囲微小環境 / 膵腺房細胞 / 腺房萎縮 / ADM / Acinar atrophy / カルパイン / 化合物ライブラリー / オートファジー / 代謝産物 / メタボリックプロファイリングマッピング / 凍結組織マイクロアレイ / MALDI-IMS / ゲムシタビン耐性 / 代謝産物膵癌 / periostin / gemcitabine / pirfenidone / pancreatic cancer / ピルフェニドン / 早期診断 / 膵癌特異的代謝産物 Less

Elucidation of the mechanism of anti-tumor effect by disabling the immune escape mechanism and development of treatment based on regulation of the pancreatic cancer microenvironmentPrincipal Investigator
- Principal Investigator
  
  ONIMARU Manabu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kyushu University
Development of a novel method to control pancreatic cancer by targeting cancer-associated adipocytes (CAAs) that lead to local invasion
- Principal Investigator
  
  TOMINAGA Yohei
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyushu University
Novel mechanism of acinar atrophy by pancreatic cancer microenvironment and its role in local invasion
- Principal Investigator
  
  SHIMAMOTO Masaya
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyushu University
Elucidation of cancer progression mechanism associated with novel forms of cell death in pancreatic cancer using organoid models
- Principal Investigator
  
  MORIYAMA Taiki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyushu University
Elucidation of genomic heterogeneity in pancreatic cancer microenvironment via NGS analysis for therapeutic development
- Principal Investigator
  
  SHINDO Koji
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyushu University
Clarification and control of immune cell-induced PSC substrate remodeling using KPCL micePrincipal Investigator
- Principal Investigator
  
  ONIMARU Manabu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Development of therapeutic agent targeting desmoplasia in pancreatic cancer and novel drug delivery system
- Principal Investigator
  
  SHIRAHANE Kengo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Elucidation of selection mechanism of disseminated cancer cells in metastatic organsPrincipal Investigator
- Principal Investigator
  
  ONIMARU Manabu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Elucidation of the radioresistance mechanism on the microenviroment of pancreatic cancer and control of the stroma cells causing radioresistance by newly artificial virus.Principal Investigator
- Principal Investigator
  
  ONIMARU Manabu
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
The development of pancreatic cancer therapy based on regulating pancreatic cancer desmoplasia by targeting pancreatic stellate cells to improve drug delivery
- Principal Investigator
  
  NAGAI Eishi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
A novel approach for early diagnosis and personalized therapy to pancreatic cancer by metabolic profiling
- Principal Investigator
  
  MIZUMOTO Kazuhiro
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Establishment of therapy for individual based on diagnostic imaging by artificial virus
- Principal Investigator
  
  TANAKA Masao
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Development of new functional artificial virus contained cancer-selective anticancer drug with the cancer-specific moleculesPrincipal Investigator
- Principal Investigator
  
  ONIMARU Manabu
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General surgery
- Research Institution
  Kyushu University
メタボロミクスによる膵癌特異的代謝物の同定と膵液診断への展開
- Principal Investigator
  
  TANAKA Masao
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
人工ウイルスを用いた新規早期ガン診断システムの構築
- Principal Investigator
  
  MIZUMOTO Kazuhiro
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University

All 2011 2010

All Journal Article

[Journal Article] Adenoviral therapy is more effective in gemcitabine-resistant pancreatic cancer than in gemcitabine-sensitive cells2011
- Author(s)
  Yasui T, Ohuchida K, Zhao M, Cui L, Onimaru M, Egami T, Fujita H, Ohtsuka T, Mizumoto M, Matsumoto K, Tanaka M
- Journal Title
  
  Anticancer Res
  
  Volume: 31(4) Pages: 1279-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791255
[Journal Article] Tumor-stroma interactions reduce the efficacy of adenoviral therapy through the HGF-MET pathway2011
- Author(s)
  Yasui T, Ohuchida K, Zhao M, Onimaru M, Egami T, Fujita H, Ohtsuka T, Mizumoto K, Tanaka M
- Journal Title
  
  Cancer science
  
  Volume: 102(2) Pages: 484-91
- NAID
  10029290639
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791255
[Journal Article] hTERT -promoter-dependent oncolytic adenovirus enhances the transduction and therapeutic efficacy of replication-defective adenovirus vectors in pancreatic cancer cells2011
- Author(s)
  Onimaru M, Ohuchida K, Mizumoto K, Nagai E, Cui L, Toma H, Takayama K, Matsumoto K, Hashizume M, Tanaka M
- Journal Title
  
  Cancer Sci
  
  Volume: 101(3) Pages: 735-742
- NAID
  10026589785
- Data Source
  KAKENHI-PROJECT-23659652
[Journal Article] Tanaka M High EGFR mRNA expression is a prognostic factor for reduced survival in pancreatic cancer after gemcitabine-based adjuvant chemotherapy2011
- Author(s)
  Fujita H, Ohuchida K, Mizumoto K, Itaba S, Ito T, Nakata K, Yu J, Kayashima T, Hayashi A, Souzaki R, Tajiri T, Onimaru M, Manabe T, Ohtsuka T
- Journal Title
  
  Int J Oncol
  
  Volume: 38(3) Pages: 629-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791255
[Journal Article] Tumor-stroma interactions reduce the efficacy of adenoviral therapy through the HGF-MET pathway2011
- Author(s)
  Yasui T, Ohuchida K, Zhao M, Onimaru M, Egami T, Fujita H, Ohtsuka T, Mizumoto K, Tanaka M
- Journal Title
  
  Cancer science
  
  Volume: 102(2) Pages: 484-491
- NAID
  10029290639
- Data Source
  KAKENHI-PROJECT-23659655
[Journal Article] Tanaka M Predicting the chemosensitivity of pancreatic cancer cells by quantifying the expression levels of genes associated with the metabolism of gemcitabine and 5-fluorouracil2011
- Author(s)
  Kurata N, Fujita H, Ohuchida K, Mizumoto K, Mahawithitwong P, Sakai H, Onimaru M, Manabe T, Ohtsuka T
- Journal Title
  
  Int J Oncol
  
  Volume: 39(2) Pages: 473-82
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791255
[Journal Article] Adenoviral therapy is more effective in gemcitabine-resistant pancreatic cancer than in gemcitabine-sensitive cells2011
- Author(s)
  Yasui T, Ohuchida K, Zhao M, Cui L, Onimaru M, Egami T, Fujita H, Ohtsuka T, Mizumoto M, Matsumoto K, Tanaka M
- Journal Title
  
  Anticancer Research
  
  Volume: 31(4) Pages: 1279-1288
- Data Source
  KAKENHI-PROJECT-23659655
[Journal Article] Combination with low-dose gemcitabine and hTERT-promoter-dependent conditionally replicative adenovirus enhances cytotoxicity through their crosstalk mechanisms in pancreatic cancer2010
- Author(s)
  Onimaru M, Ohuchida K, Nagai E, Mizumoto K, Egami T, Cui L, Sato N, Uchino J, Takayama K, Hashizume M, Tanaka M.
- Journal Title
  
  Cancer Lett.
  
  Volume: 294(2) Pages: 178-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791255
[Journal Article] Gencitabime synergistically enhances the effect of adenovirus gene therapy through activation of the CMV promoter in2010
- Author(s)
  Onimaru M, Ohuchida K, Egami T, Mizumoto K, Nagai E, Cui L, Toma H, Matsumoto K, Hashizume M, Tanaka M.
- Journal Title
  
  pancreatic cancer cells Cancer Gene Ther
  
  Volume: 17(8) Pages: 541-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791255

1. 大内田研宙 (20452708)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
2. MIZUMOTO Kazuhiro (90253418)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. INOUE Shigetaka (00529802)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. SHIRAHANE Kengo (10529803)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. EGAMI Takuya (40507787)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
6. 寅田信博 (00398075)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. TANAKA Masao (30163570)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
8. MORIYAMA Taiki (70586859)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. NAGAI Eishi (30264021)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. TAKAHATA Shunichi (50437779)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SHIMAMOTO Masaya (00457433)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SHINDO Koji (00788432)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TOMINAGA Yohei (90304823)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 真鍋達也 (60546464)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 難波江俊永 (10467889)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 三好圭 (70755272)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 岩本千佳 (10752842)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 宮坂義浩 (40507795)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 前山良 (10611668)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 仲田興平 (30419569)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 池永直樹 (90759755)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 中村雅史 (30372741)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 千々岩芳朗 (60783701)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 永吉絹子 (90761015)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Onimaru Manabu 鬼丸 学

ONIMARU Manabu 鬼丸 学

Research Projects

Research Products

Co-Researchers

Elucidation of the mechanism of anti-tumor effect by disabling the immune escape mechanism and development of treatment based on regulation of the pancreatic cancer microenvironmentPrincipal Investigator

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Clarification and control of immune cell-induced PSC substrate remodeling using KPCL micePrincipal Investigator

Principal Investigator

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Research Field

Research Institution

Principal Investigator

Project Period (FY)

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Elucidation of selection mechanism of disseminated cancer cells in metastatic organsPrincipal Investigator

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Research Institution

Elucidation of the radioresistance mechanism on the microenviroment of pancreatic cancer and control of the stroma cells causing radioresistance by newly artificial virus.Principal Investigator

Principal Investigator

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Principal Investigator

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Development of new functional artificial virus contained cancer-selective anticancer drug with the cancer-specific moleculesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Onimaru Manabu 鬼丸学

ONIMARU Manabu 鬼丸学