Hayashi Ken 林賢

… Alternative Names

HAYASHI Ken 林賢

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Researcher Number	80534528
Other IDs
Affiliation (Current)	2025: 慶應義塾大学, 医学部(信濃町), 共同研究員
Affiliation (based on the past Project Information) *help	2019 – 2023: 慶應義塾大学, 医学部(信濃町), 共同研究員
Review Section/Research Field	Principal Investigator Basic Section 56050:Otorhinolaryngology-related
Keywords	Principal Investigator エクソソーム / オートファジー / 老化ミクログリア / DAMPs / 内耳細胞死 / 酸化ストレス / SASP / 内耳細胞老化 / LaminB1 / cGAS-STING … More / Nucleophagy / NaAsO2 / 耳鳴 / Toll-Like-Receptor 7 / miRNA let-7b / CMOS-アレイ / ミスマッチ陰性電位 / 内耳細胞過興奮性細胞死 / CMOS-MEA / 初代培養神経細胞 / TLR-7 / 初代神経培養細胞 / 間歇的自発バースト / ミスマッチネガティビティ / 異種細胞間コミュニケーション / エクソソームmiRNA let-7b Less

内耳細胞死由来エクソソーム・DAMPsが海馬の空間情報処理に及ぼす影響の解明Principal Investigator
- Principal Investigator
  
  林賢
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Keio University
Cross-talk analysis between heterotypic cell-cell communication via siRNA/TLR7 and new therapeutic strategyPrincipal Investigator
- Principal Investigator
  
  HAYASHI Ken
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Keio University

All 2023 2022 2021 2020 2019 Other

All Journal Article Presentation Other

[Journal Article] Molecular Mechanisms and Biological Functions of Autophagy for Genetics of Hearing Impairment.2020
- Author(s)
  Ken Hayashi, Yuna Suzuki Y, Chisato Fujimoto, Sho Kanzaki
- Journal Title
  
  Genes
  
  Volume: 11 Issue: 11 Pages: 1331-1331
- DOI
  10.3390/genes11111331
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09899, KAKENHI-PROJECT-18K09369
[Journal Article] Casper-8 Regulates Endoplasmic Reticulum Stress-Induced Necroptosis Independent of the Apotosis Pathway in Auditor Cells2019
- Author(s)
  Kishino A, Hayashi K, Maeda M, Jike T, Hidai C, Nomura Y, Oshima T.
- Journal Title
  
  Int J. Mol. Sci.
  
  Volume: 20(23) Issue: 23 Pages: 5896-5896
- DOI
  10.3390/ijms20235896
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09358, KAKENHI-PROJECT-19K09899, KAKENHI-PROJECT-19K09916, KAKENHI-PROJECT-19K18747
[Presentation] TFEB活性低下とリソソーム損傷が内耳細胞老化に及ぼす影響2023
- Author(s)
  林　賢、五島史行、野村泰之、鴨頭輝，藤本千里
- Organizer
  第124回日本耳鼻咽喉科頭頸部外科学会総会・学術講演会第3群　耳研究1
- Data Source
  KAKENHI-PROJECT-22K09674
[Presentation] TFEB,オートファジー・リソソーム経路, 細胞内ROS間のクロストークによる内耳細胞老化制御2023
- Author(s)
  林　賢、五島史行、野村泰之、鴨頭輝，藤本千里
- Organizer
  第33回　日本耳科学会総会・学術講演会第15群　基礎2　第５会場
- Data Source
  KAKENHI-PROJECT-22K09674
[Presentation] 酸化ストレス誘導性内耳細胞老化におけるTFEBを焦点としたオートファジー・リソソーム経路制御機構の解明2023
- Author(s)
  林　賢、鈴木佑奈、槇島　誠
- Organizer
  第23回日本抗加齢医学会総会一般口演10　「細胞基礎 / 細胞臨床」
- Data Source
  KAKENHI-PROJECT-22K09674
[Presentation] TFEBによるオートファジー・リソソーム経路活性化を介した内耳細胞老化制御メカニズムの解明2022
- Author(s)
  林　賢
- Organizer
  第32回　日本耳科学会　総会・学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-22K09674
[Presentation] TFEBによるオートファジー・リソソーム経路活性化を介した内耳細胞老化制御メカニズムの解明2022
- Author(s)
  林　賢
- Organizer
  第32回　日本耳科学会　総会・学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-19K09899
[Presentation] Exosomal miRNA let-7b modulates the interaction between TLR7 and TRPA1, inducing hyperexcitability-induced cell death in auditory cell2022
- Author(s)
  Ken Hayashi, Hideaki Sakata
- Organizer
  49th Congress of the Neurootological and Equilibriometric Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09899
[Presentation] Exosomal miRNA let-7b modulates the interaction between TLR7 and TRPA1, inducing hyperexcitability-induced cell death in auditory cell2022
- Author(s)
  Ken Hayashi, Hideaki Sakata
- Organizer
  49th Congress of the Neurootological and equillibriometric society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09674
[Presentation] The functions of exosomal miRNA let-7b as a top-down signal disrupting the neural network in the auditory-brain2022
- Author(s)
  Ken Hayashi, Hideaki Sakata
- Organizer
  49th Congress of the Neurootological and Equilibriometric Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09899
[Presentation] The functions of exosomal miRNA let-7b as a top-down signal disrupting the neural network in the auditory-brain2022
- Author(s)
  Ken Hayashi, Hideaki Sakata
- Organizer
  49th Congress of the Neurootological and equillibriometric society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09674
[Presentation] The effect of exosomal miRNA let-7b to the mismatch negativity as an auditory memory traces in cellular neural network.2021
- Author(s)
  Ken Hayashi, Yuna Suzuki, Fumiyuki Goto, Yasuyuki Nomura, Sho Kanzaki, Chisato Fujimoto.
- Organizer
  The 125th American Academy Otolaryngology-Head and Neck Surgery Foundation Annual Meeting & OTO EXPO
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09899
[Presentation] Exosomal miRNA let-7b inducing hyperexcitability-induced auditory cell death decrease the auditory sensorial memory in cellular neural network2021
- Author(s)
  Ken Hayashi Hideaki Sakata1
- Organizer
  The 48th NES Congress online
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09899
[Presentation] The impact of extracellular miRNA let-7b as a top-down signal in the auditory-brain.2020
- Author(s)
  Ken Hayashi, Yuna Suzuki, Fumiyuki Goto, Akihiro Kishino, and Kaoru Ogawa
- Organizer
  American Academy Otolaryngology-Head and Neck Surgery Foundation Annual Meeting & OTO EXPO
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09899
[Presentation] The interaction of TRL7 with TRPA1 drives hyperexcitability cell death modulated by miRNA let-7b in auditory cells.2020
- Author(s)
  Ken Hayashi, Yuna Suzuki, Akihiro Kishino, Fumiyuki Goto, Kaoru Ogawa
- Organizer
  43RD Association of research in Otolaryngology, Midwinter Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09899
[Presentation] Autophagy Signaling Mechanisms Controlling Cell Fate in Auditory Cells -Cell death and Cellular Senescence-2019
- Author(s)
  Ken Hayashi
- Organizer
  The 25th Ajou Otology Symposium
- Invited
- Data Source
  KAKENHI-PROJECT-19K09899
[Presentation] The effect of hyperexcitability-induced cell death modulated by miRNA let-7b in the auditory-brain2019
- Author(s)
  Ken Hayashi, Fumiyuki Goto, Yuna Suzuki, Akihiro Kishino, Sho Kanzaki, Kaoru Ogawa
- Organizer
  12thAPSCI
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09899
[Presentation] TLR7-TRPA1 interaction drives hyperexcitability cell death modulated by miRNA let-7b in auditory cells2019
- Author(s)
  Ken Hayashi, Fumiyuki Goto, Akihiro Kishino, Yuna Suzuki, Yasuyuki Nomura, Sho Kanzaki, Kaoru Ogawa
- Organizer
  ICORL 2019 Symposium, Basic research in hearing loss
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09899
[Presentation] The cross-talk between exosomal miRNA, apoptosis and autophagy in auditory cell death2019
- Author(s)
  Ken Hayashi, Fumiyuki Goto, Akihiro Kishino, Yuna Suzuki, Yasuyuki Nomura, Sho Kanzaki, Kaoru Ogawa
- Organizer
  123thAAO-HNSF
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09899
[]

1. 神崎晶 (50286556)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. 高橋宏知 (90361518)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 高島明彦 (00154774)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 日台智明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 野村泰之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hayashi Ken 林 賢

HAYASHI Ken 林 賢

Research Projects

Research Products

Co-Researchers

内耳細胞死由来エクソソーム・DAMPsが海馬の空間情報処理に及ぼす影響の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Cross-talk analysis between heterotypic cell-cell communication via siRNA/TLR7 and new therapeutic strategyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Molecular Mechanisms and Biological Functions of Autophagy for Genetics of Hearing Impairment.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Casper-8 Regulates Endoplasmic Reticulum Stress-Induced Necroptosis Independent of the Apotosis Pathway in Auditor Cells2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] TFEB活性低下とリソソーム損傷が内耳細胞老化に及ぼす影響2023

Author(s)

Organizer

Data Source

[Presentation] TFEB,オートファジー・リソソーム経路, 細胞内ROS間のクロストークによる内耳細胞老化制御2023

Author(s)

Organizer

Data Source

[Presentation] 酸化ストレス誘導性内耳細胞老化におけるTFEBを焦点としたオートファジー・リソソーム経路制御機構の解明2023

Author(s)

Organizer

Data Source

[Presentation] TFEBによるオートファジー・リソソーム経路活性化を介した内耳細胞老化制御メカニズムの解明2022

Author(s)

Organizer

Data Source

[Presentation] TFEBによるオートファジー・リソソーム経路活性化を介した内耳細胞老化制御メカニズムの解明2022

Author(s)

Organizer

Data Source

[Presentation] Exosomal miRNA let-7b modulates the interaction between TLR7 and TRPA1, inducing hyperexcitability-induced cell death in auditory cell2022

Author(s)

Organizer

Data Source

[Presentation] Exosomal miRNA let-7b modulates the interaction between TLR7 and TRPA1, inducing hyperexcitability-induced cell death in auditory cell2022

Author(s)

Organizer

Data Source

[Presentation] The functions of exosomal miRNA let-7b as a top-down signal disrupting the neural network in the auditory-brain2022

Author(s)

Organizer

Data Source

[Presentation] The functions of exosomal miRNA let-7b as a top-down signal disrupting the neural network in the auditory-brain2022

Author(s)

Organizer

Data Source

[Presentation] The effect of exosomal miRNA let-7b to the mismatch negativity as an auditory memory traces in cellular neural network.2021

Author(s)

Organizer

Data Source

[Presentation] Exosomal miRNA let-7b inducing hyperexcitability-induced auditory cell death decrease the auditory sensorial memory in cellular neural network2021

Author(s)

Organizer

Data Source

[Presentation] The impact of extracellular miRNA let-7b as a top-down signal in the auditory-brain.2020

Author(s)

Organizer

Data Source

[Presentation] The interaction of TRL7 with TRPA1 drives hyperexcitability cell death modulated by miRNA let-7b in auditory cells.2020

Author(s)

Organizer

Data Source

[Presentation] Autophagy Signaling Mechanisms Controlling Cell Fate in Auditory Cells -Cell death and Cellular Senescence-2019

Hayashi Ken 林賢

HAYASHI Ken 林賢