MUNEKATA (TOKUNAGA) Yuko 宗片優子

… Alternative Names

徳永優子

徳永優子トクナガユウコ

TOKUNAGA Yuuko 徳永優子

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Researcher Number	80555011
Affiliation (based on the past Project Information) *help	2020 – 2021: 公益財団法人東京都医学総合研究所, 疾患制御研究分野, 主任研究員 2014 – 2018: 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 研究員 2011: 財団法人東京都医学総合研究所, ゲノム医科学研究分野, 研究員 2010: (財)東京都医学研究機構, 東京都臨床医学総合研究所, 研究員 2009 – 2010: 財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 研究員
Review Section/Research Field	Principal Investigator Basic Section 49060:Virology-related / Virology Except Principal Investigator Virology / Biological Sciences
Keywords	Principal Investigator 肝正常化 / 阻害剤 / Wnt/β-catenin/CBP / 空間的遺伝子発現解析 / 脱老化作用 / RNAシーケンス解析 / ATP産生亢進 / ミトコンドリア / 肝正常化作用 / コラーゲン線維合成系 … More / 1細胞トランスクリプトーム解析 / マトリックスメタロプロテアーゼ / 好中球 / マクロファージ / コラーゲン線維分解系 / 脱線維化作用 / 新規肝硬変治療薬候補 … More Except Principal Investigator C型肝炎ウイルス / 増殖抑制 / インフルエンザウイルス / 特殊環状ペプチド / 免疫学 / 微生物 / 感染症 / ウイルス / スフィンゴ肪質 / 遺伝子複製 / 細胞内逆輸送 / SPT / RdRp / 脂質ラフト / HCV複製 / スフィンゴ脂質 / 細胞 / 間発がん / 慢性炎症 / 免疫応答 / 持続感染 Less

選択的Wnt/β-catenin/CBP阻害剤による肝正常化機序の解明Principal Investigator
- Principal Investigator
  
  宗片優子 (徳永優子)
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
iHA-100 exhibited a high efficacy whether administered during the early phase or late phase of H5N1 infection
- Principal Investigator
  
  KOHARA Michinori
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Analysis of mechanism of anti-fibrotic effect by a liver cirrhosis treatment drug candidatePrincipal Investigator
- Principal Investigator
  
  MUNEKATA (TOKUNAGA) Yuko
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
免疫系の攪乱によるC型肝炎ウイルスの持続感染化及び発症機序の解析とその制御
- Principal Investigator
  
  KOHARA Michinori
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
The specific SM molecular species that these endogenous SM species interacted with HCV nonstructural 5B polymerase to enhance viral replication
- Principal Investigator
  
  KOHARA Michinori
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  財団法人東京都医学総合研究所
   Tokyo Metropolitan Organization for Medical Research

All 2017 2016 2015 2014 2011 2010 2009 Other

All Journal Article Presentation

[Journal Article] Selective inhibitor of Wnt/β-catenin/CBP signaling ameliorates hepatitis C virus-induced liver fibrosis in mouse model2017
- Author(s)
  Yuko Tokunaga, Yosuke Osawa, Takahiro Ohtsuki, Yukiko Hayashi, Kenzaburo Yamaji, Daisuke Yamane, Mitsuko Hara, Keisuke Munekata, Kyoko Tsukiyama-Kohara, Tsunekazu Hishima, Soichi Kojima, Kiminori Kimura, and *Michinori Kohara
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 325-325
- DOI
  10.1038/s41598-017-00282-w
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01272, KAKENHI-PROJECT-15H04739, KAKENHI-PROJECT-26460965, KAKENHI-PROJECT-26860312, KAKENHI-PROJECT-16K18467, KAKENHI-PROJECT-17K15584, KAKENHI-PROJECT-15K15146
[Journal Article] M2 macrophages play critical roles in progression of inflammatory liver disease in hepatitis C virus transgenic mice.2015
- Author(s)
  1.Ohtsuki T, Kimura K, Tokunaga Y, Tsukiyama-Kohara K, Tateno C, Hayashi Y, Hishima T, Kohara M
- Journal Title
  
  J Virol
  
  Volume: Oct 14;90(1) Issue: 1 Pages: 300-7
- DOI
  10.1128/jvi.02293-15
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09037, KAKENHI-PROJECT-15K15146, KAKENHI-PROJECT-26860312, KAKENHI-PUBLICLY-15H01272, KAKENHI-PROJECT-15H04739, KAKENHI-PROJECT-24390117
[Journal Article] Suppression of hepatitis C virus replication by cyclin-dependent kinase inhibitors2014
- Author(s)
  Tsubasa Munakata, Makoto Inada, Yuko Tokunaga, Takaji Wakita, Michinori Kohara, Akio Nomoto
- Journal Title
  
  Antiviral Research
  
  Volume: 108 Pages: 79-87
- DOI
  10.1016/j.antiviral.2014.05.011
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390117, KAKENHI-PROJECT-24590565, KAKENHI-PUBLICLY-25114712, KAKENHI-PROJECT-26860312
[Journal Article] Hepatitis C virus impairs P53 via persistent over-expression of 3β-hydroxysterolΔ24-reductase2009
- Author(s)
  Nishimura T., Kohara M., Izumi K., Kasama Y., Hirata Y., Huang Y., Shuda M., Nuriya H., Tokunaga Y., Sato M., Saito M., Kai C. and Tsukiyama-Kohara K.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 284(52) Pages: 36442-36452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390145
[Presentation] 弱毒化ワクシニアウイルスDIs株を母体とした組換えH5亜型HAインフルエンザワクチンによる発症防御機序の解析2017
- Author(s)
  安井文彦、宗片圭佑、本田智子、伊藤靖、迫田義博、喜田宏、阪口薫雄、小笠原一誠、小原道法
- Organizer
  第21回日本ワクチン学会
- Data Source
  KAKENHI-PROJECT-15H04739
[Presentation] Wnt/β-catenin/CBPシグナル阻害剤PRI-724はNASHによる肝線維を消失させる2017
- Author(s)
  山地賢三郎、徳永優子、大槻貴博、大澤陽介、木村公則、小原道法
- Organizer
  第53回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-26860312
[Presentation] ワクチニアウイルスDls株を母体としたインフルエンザHA組換えワクチンのカニクイザルでの八章防御効果の検討2016
- Author(s)
  宗片圭祐、安井文彦、伊藤　靖、石井孝司、喜田　宏、小笠原一誠、小原道法
- Organizer
  第20回日本ワクチン学会学術集会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2016-10-22
- Data Source
  KAKENHI-PROJECT-15H04739
[Presentation] Amelioration of HCV liver fibrosis by selective inhibitor of Wnt/β-catenin/CBP signaling2016
- Author(s)
  Tokunaga Y., Osawa Y., Ohtsuki K., Yamaji K., Yamane D., Munekata K., Hara M., Kojima S., Kimura K., Kohara M.
- Organizer
  23rd International Symposium on Hepatitis C Virus and Related Viruses
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2016-10-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04739
[Presentation] Selective inhibitor of Wnt/b-catenin/CBP signaling ameliorates hepatitis C virus-induced liver fibrosis in mice2015
- Author(s)
  Tokunaga Y, Kimura K, Ohtsuki T, Hayashi Y, Munekata K, Hishima T, Kohara, M
- Organizer
  第50回ヨーロッパ肝臓学会
- Place of Presentation
  Vienna, Austria
- Year and Date
  2015-04-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860312
[Presentation] Selective Wnt/b-catenin/CBP signaling inhibitor ameliorates hepatitis C viurs-induced liver fibrosis2015
- Author(s)
  Tokunaga Y, Kimura K, Kohara M
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26860312
[Presentation] Novel infectious clone of HCV 1a strain HCV-RMT efficiently replicate in vitro and in vivo using adaptive mutations2011
- Author(s)
  Tokunaga Y.
- Organizer
  18th International Symposium Hepatitis C Virus and Related Viruses
- Place of Presentation
  Seattle(米国)
- Year and Date
  2011-09-10
- Data Source
  KAKENHI-PROJECT-21390145
[Presentation] Novel infectious clone of HCV 1a strain HCV-RMT efficiently replicate in vitro and in vivo using adaptive mutations2011
- Author(s)
  Tokunaga Y.
- Organizer
  18^<th> International Symposium Hepatitis C Virus and Related Viruses
- Place of Presentation
  Seattle(米国)
- Year and Date
  2011-09-10
- Data Source
  KAKENHI-PROJECT-21390145
[Presentation] 感染性粒子を放出するHCV遺伝子型1aクローン(HCV-RMT)の樹立2010
- Author(s)
  徳永優子
- Organizer
  第58回日本ウイルス学会学術集会
- Place of Presentation
  徳島県郷土文化会館(徳島)
- Year and Date
  2010-11-07
- Data Source
  KAKENHI-PROJECT-21390145
[Presentation] 感染性粒子を放出するHCV遺伝子型1aクローン(HCV-RMT)の樹立2010
- Author(s)
  徳永優子
- Organizer
  第58回日本ウイルス学会学術集会
- Place of Presentation
  徳島県郷土文化会館(徳島)
- Year and Date
  2010-11-07
- Data Source
  KAKENHI-PUBLICLY-21022054
[Presentation] 選択的Wnt/beta-catenin/CBPシグナル阻害剤による肝線維症改善作用
- Author(s)
  徳永優子、木村公則、大槻貴博、林幸子、原詳子、宗片圭祐、比島恒和、小嶋聡一、小原道法
- Organizer
  第62回日本ウイルス学会学術集会
- Place of Presentation
  パシフィコ横浜（神奈川）
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-26860312
[Presentation] Selective inhibitor of Wnt/beta-catenin/CBP signaling ameliorates hepatitis C virus-induced liver fibrosis
- Author(s)
  Tokunaga Y, Kimura K, Ohtsuki T, Hayashi Y, Hara M, Munekata K, Hishima T, Kouji H, Kojima S, Kohara M
- Organizer
  21th International Symposium on Hepatitis C Virus and Related Viruses
- Place of Presentation
  Banff, Canada
- Year and Date
  2014-09-07 – 2014-09-11
- Data Source
  KAKENHI-PROJECT-26860312

1. KOHARA Michinori (10250218)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
2. HIRATA Yuuichi (50439452)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. MUNAKATA Tsubasa (50420237)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. 安井文彦 (40399473)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 関口敏 (10462780)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 齊藤誠 (20433021)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. HAYASHI Yukiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. IMAI Yumiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KIMURA Kiminori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MUNEKATA (TOKUNAGA) Yuko 宗片 優子

徳永優子

徳永 優子 トクナガ ユウコ

TOKUNAGA Yuuko 徳永 優子

Research Projects

Research Products

Co-Researchers

選択的Wnt/β-catenin/CBP阻害剤による肝正常化機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

iHA-100 exhibited a high efficacy whether administered during the early phase or late phase of H5N1 infection

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of mechanism of anti-fibrotic effect by a liver cirrhosis treatment drug candidatePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

免疫系の攪乱によるC型肝炎ウイルスの持続感染化及び発症機序の解析とその制御

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The specific SM molecular species that these endogenous SM species interacted with HCV nonstructural 5B polymerase to enhance viral replication

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Selective inhibitor of Wnt/β-catenin/CBP signaling ameliorates hepatitis C virus-induced liver fibrosis in mouse model2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] M2 macrophages play critical roles in progression of inflammatory liver disease in hepatitis C virus transgenic mice.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Suppression of hepatitis C virus replication by cyclin-dependent kinase inhibitors2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hepatitis C virus impairs P53 via persistent over-expression of 3β-hydroxysterolΔ24-reductase2009

Author(s)

Journal Title

Data Source

[Presentation] 弱毒化ワクシニアウイルスDIs株を母体とした組換えH5亜型HAインフルエンザワクチンによる発症防御機序の解析2017

Author(s)

Organizer

Data Source

[Presentation] Wnt/β-catenin/CBPシグナル阻害剤PRI-724はNASHによる肝線維を消失させる2017

Author(s)

Organizer

Data Source

[Presentation] ワクチニアウイルスDls株を母体としたインフルエンザHA組換えワクチンのカニクイザルでの八章防御効果の検討2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Amelioration of HCV liver fibrosis by selective inhibitor of Wnt/β-catenin/CBP signaling2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Selective inhibitor of Wnt/b-catenin/CBP signaling ameliorates hepatitis C virus-induced liver fibrosis in mice2015

Author(s)

Organizer

Place of Presentation

MUNEKATA (TOKUNAGA) Yuko 宗片優子

徳永優子トクナガユウコ

TOKUNAGA Yuuko 徳永優子