Hirota Yushi 廣田勇士

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HIROTA Yushi 廣田勇士

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Researcher Number	80566018
Other IDs
Affiliation (Current)	2025: 神戸大学, 医学研究科, 准教授
Affiliation (based on the past Project Information) *help	2025: 神戸大学, 医学研究科, 准教授 2020 – 2021: 神戸大学, 医学研究科, 准教授 2019: 神戸大学, 医学部附属病院, 講師 2016 – 2018: 神戸大学, 医学部附属病院, 助教 2012: 神戸大学, 医学部附属病院・糖尿病・内分泌内科, 助教 2010 – 2012: 神戸大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Metabolomics Except Principal Investigator Anesthesiology
Keywords	Principal Investigator PIK3R1遺伝子 / iPS細胞 / エクソーム解析 / インスリン抵抗症 / 糖尿病 / PIK3R1 / インスリン受容体遺伝子 / CRISPR/Cas9 / エネルギー・糖質代謝異常 / SHORT症候群 … More / ディスポジション・インデックス / ディスポジション・インデック / 正常血糖高インスリンクランプ / 高血糖クランプ / インスリン抵抗性 / インスリン分泌能 / 遺伝因子 … More Except Principal Investigator 血糖変動 / 急性期 / 血糖管理 / 酸化ストレス / 好中球機能 / 糖尿病 / 敗血症 / 変動 / 血糖 Less

CGMデータとAIを活用した糖尿病診療支援システムの開発Principal Investigator
- Principal Investigator
  
  廣田勇士
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kobe University
Search for the causative gene of genetic insulin resistance syndrome and analysis of the pathogenesis using patient iPS cells.Principal Investigator
- Principal Investigator
  
  Hirota Yushi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kobe University
Identification of the gene that causes insulin resistance syndrome using exome sequencing and iPS cells.Principal Investigator
- Principal Investigator
  
  Hirota Yushi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kobe University
The impact of acute glycemic index on the outcome in septic patients with presence of diabetes.
- Principal Investigator
  
  EGI MORITOKI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Kobe University
Research on new method for evaluating insulin secretion, and association with the genetic factorsPrincipal Investigator
- Principal Investigator
  
  HIROTA Yushi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Kobe University

All 2022 2021 2020 2019 2018 2017 2013 2012 2011 2010 Other

All Journal Article Presentation Patent Other

[Journal Article] New classification and diagnostic criteria for insulin resistance syndrome.2022
- Author(s)
  Ogawa W, Araki E, Ishigaki Y, Hirota Y, Maegawa H, Yamauchi T, Yorifuji T, Katagiri H.
- Journal Title
  
  Diabetol Int.
  
  Volume: 13 Issue: 2 Pages: 337-343
- DOI
  10.1007/s13340-022-00570-5
- NAID
  130008164801
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08981, KAKENHI-PROJECT-21K08533, KAKENHI-PROJECT-20H05694
[Journal Article] New classification and diagnostic criteria for insulin resistance syndrome2022
- Author(s)
  Ogawa W, Araki E, Ishigaki Y, Hirota Y, Maegawa H, Yamauchi T, Yorifuji T, Katagiri H.
- Journal Title
  
  Endocr J
  
  Volume: 69 Issue: 2 Pages: 107-113
- DOI
  10.1507/endocrj.EJ21-0725
- NAID
  130008164801
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08981, KAKENHI-PROJECT-21K08533, KAKENHI-PROJECT-20H05694
[Journal Article] Treatment of a case of severe insulin resistance due to a PIK3R1 mutation with a sodium-glucose cotransporter-2 inhibitor.2018
- Author(s)
  Hamaguchi T, Hirota Y, Takeuchi T, Nakagawa Y, Matsuoka A, Matsumoto M, Awano H, Iijima K, Cha PC, Satake W, Toda T, Ogawa W.
- Journal Title
  
  J Diabetes Investig.
  
  Volume: 9 Issue: 5 Pages: 1224-1227
- DOI
  10.1111/jdi.12825
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09750, KAKENHI-PROJECT-17H04056
[Journal Article] C-peptide response to glucagon challenge predicts improvement by liraglutide of both early insulin secretion and glucose tolerance2012
- Author(s)
  Takabe M, Matsuda T, Hirota Y, Hashimoto N, Nakamura T, Sakaguchi K, Ogawa W, Seino S
- Journal Title
  
  Diabetes Res Clin Pract
  
  Volume: Epub ahead of print Issue: 3 Pages: e32-e35
- DOI
  10.1016/j.diabres.2012.09.036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790862, KAKENHI-PROJECT-24229007
[Journal Article] Variations with modest effects have an important role in the genetic background of type 2 diabetes and diabetes-related traits2012
- Author(s)
  Fujita H, Hara K, Kadowaki T
- Journal Title
  
  J Hum Genet
  
  Volume: 57 Issue: 12 Pages: 776-779
- DOI
  10.1038/jhg.2012.110
- NAID
  10031145885
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229008, KAKENHI-PROJECT-22790862, KAKENHI-PROJECT-24229007, KAKENHI-PROJECT-24510276
[Journal Article] A Minimally Invasive System for Glucose Area under the Curve Measurement using Interstitial Fluid Extraction Technology: Evaluation of the Accuracy and Usefulness with OGTTs in Diabetic and Nondiabetic Subjects2012
- Author(s)
  Sakaguchi K, Hirota Y, Hashimoto N, Ogawa W, Sato T, Okada S, Hagino K, Asakura Y, Kikkawa Y, Kojima J, Maekawa Y, Nakajima H
- Journal Title
  
  Diabetes Technol Ther
  
  Volume: 14(6) Pages: 485-491
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790862
[Journal Article] Age-dependent decline in β-cell function assessed by an oral glucose tolerance test-based disposition index2011
- Author(s)
  Komada H, Sakaguchi K, Takeda K, Hirota Y, Hashimoto N, Okuno Y, Seino S, Ogawa W
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: 2(4) Issue: 4 Pages: 293-296
- DOI
  10.1111/j.2040-1124.2010.00099.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790862
[Journal Article] Age-dependent decline in β-cell function assessed by an oral glucose tolerance test-based disposition index
- Author(s)
  Hisako Komada, Kazuhiko Sakaguchi, Kazuo Takeda, Yushi Hirota, 以下4名省略
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790862
[Patent] 糖尿病予防又は治療剤スクリーニング方法、及び当該方法に用いる細胞2018
- Inventor(s)
  小川渉、青井貴之、廣田勇士、浜口哲矢
- Industrial Property Rights Holder
  小川渉、青井貴之、廣田勇士、浜口哲矢
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-16K09750
[Presentation] 反応性低血糖により診断に至ったA型インスリン抵抗症の1例2021
- Author(s)
  西影星二、廣田勇士、高吉倫史、竹内健人、浜口哲矢、稲葉惟子、芳野啓、山本雅昭、福岡秀規、小川渉
- Organizer
  第64回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K08981
[Presentation] インスリン抵抗性もしくは成長障害から新規変異を含むPIK3R1遺伝子変異の同定に至った3家系の報告2021
- Author(s)
  高吉倫史、廣田勇士、竹内健人、山本あかね、中川靖、浜口哲矢、三村由卯、川北理恵、依藤亨、小川渉
- Organizer
  第64回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K08981
[Presentation] PI3-キナーゼ調節サブユニット(PIK3R1)異常によるインスリン抵抗症患者由来iPS細胞を用いたPI3-キナーゼ経路障害の解析2020
- Author(s)
  浜口哲矢、廣田勇士、青井三千代、青井貴之、小川渉
- Organizer
  第63回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K08981
[Presentation] Generation Of Induced Pluripotent Stem Cells Derived From A Patient With PIK3R1 Mutation And Analysis Of Defects In Insulin Action In Hepatocytes Differentiated From These Cells2020
- Author(s)
  Tetsushi Hamaguchi,, Yushi Hirota, Takehito Takeuchi, Michiyo Koyanagi-Aoi, Takashi Aoi, Wataru Ogawa
- Organizer
  American Diabetes Association (ADA) 80th Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08981
[Presentation] PI 3-キナーゼ調節サブユニット異常による遺伝的インスリン抵抗症の解析2020
- Author(s)
  竹内健人，廣田勇士，浜口哲矢，佐竹渉，戸田達史，小川渉
- Organizer
  第63回糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K08981
[Presentation] インスリン抵抗症のINSR 遺伝子およびPIK3R1遺伝子の遺伝子解析2019
- Author(s)
  竹内健人、廣田勇士、石垣泰、門脇弘子、依藤亨、赤水尚史、小川渉、片桐秀樹
- Organizer
  第62回糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K08981
[Presentation] PI3キナーゼ遺伝子異常によるインスリン抵抗症の同定と iPS 細胞を用いた障害の解析2018
- Author(s)
  浜口哲矢、廣田勇士、松本真明、粟野宏之、飯島一誠、佐竹渉、戸田達史、青井三千代、青井貴之、小川渉
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K09750
[Presentation] PIK3R1 遺伝子異常によるインスリン抵抗症に対する SGLT2 阻害薬の有効性・安全性の検討2018
- Author(s)
  浜口哲矢、廣田勇士、松岡敦子、竹内健人、中川靖、岡田裕子、青井三千代、青井貴之、坂口一彦、小川渉
- Organizer
  第55回日本糖尿病学会近畿地方会
- Data Source
  KAKENHI-PROJECT-16K09750
[Presentation] インスリン受容体以後のシグナル伝達障害が疑われるインスリン抵抗症に対する SGLT2阻害薬の有効性と安全性の検討2017
- Author(s)
  浜口哲矢、廣田勇士、松岡敦子、竹内健人、末松那都、三浦洋、宗杏奈、中村友昭、駒田久子、岡田裕子、坂口一彦、小川渉
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K09750
[Presentation] グルコースクランプ法を用いた内分泌疾患における耐糖能の検討2013
- Author(s)
  駒田久子、廣田勇士、坂口一彦、中村友昭、福岡秀規、橋本尚子、井口元三、高橋裕、小川渉、清野進
- Place of Presentation
  浜松
- Year and Date
  2013-01-27
- Data Source
  KAKENHI-PROJECT-22790862
[Presentation] 75g OGTTにおける負荷後1時間血糖値の臨床的意義2012
- Author(s)
  駒田久子、坂口一彦、中村友昭、井口元三、橋本尚子、廣田勇士、小川渉、清野進
- Organizer
  第49回日本糖尿病学会近畿地方会
- Place of Presentation
  京都
- Year and Date
  2012-11-17
- Data Source
  KAKENHI-PROJECT-22790862
[Presentation] 褐色細胞腫術前後におけるインスリン分泌能および抵抗性評価2011
- Author(s)
  井上喜文、坂口一彦、廣田勇士、駒田久子、奥野陽子、近藤奈央、松木核、高部倫敬、松田友和、橋本尚子、井口元三、高橋裕、清野進、小川渉
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PROJECT-22790862
[Presentation] 内分泌疾患のグルコースクランプによるインスリン分泌抵抗性評価2011
- Author(s)
  井上喜文、坂口一彦、廣田勇士、駒田久子、奥野陽子、近藤奈央、松木核、高部倫敬、松田友和、橋本尚子、井口元三、高橋裕、清野進、小川渉
- Organizer
  第20回臨床内分泌代謝Update
- Place of Presentation
  札幌
- Year and Date
  2011-01-29
- Data Source
  KAKENHI-PROJECT-22790862
[Presentation] oral disposition indexによる膵β細胞機能と年齢の関係2011
- Author(s)
  駒田久子、廣田勇士、坂口一彦、奥野陽子、松田友和、橋本尚子、清野進、小川渉
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PROJECT-22790862
[Presentation] 内分泌疾患のグルコースクランプによるインスリン分泌抵抗性評価2011
- Author(s)
  井上喜文・坂口一彦・廣田勇士, 以下11名省略
- Organizer
  第20回臨床内分泌代謝Update
- Place of Presentation
  札幌コンベンションセンター(北海道)(招待講演)
- Year and Date
  2011-01-29
- Data Source
  KAKENHI-PROJECT-22790862
[Presentation] 2型糖尿病患者の高血糖クランプ時のインスリン分泌パターンとその臨床像2010
- Author(s)
  駒田久子、坂口一彦、隅田健太郎、神野歩、有村愛子、西海智子、奥野陽子、橋本尚子、廣田勇士、井口元三、小川渉、清野進
- Organizer
  第53回日本糖尿病学会年次学術集会
- Place of Presentation
  岡山
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-22790862
[]

1. EGI MORITOKI (20423296)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. Ogawa Wataru

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. Aoi Takashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. Satake Wataru

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. Wakabayashi Junji

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Furushima Nana

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Hokka Mai

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Mizobuchi Satoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. HARA Kazuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 門脇孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hirota Yushi 廣田 勇士

HIROTA Yushi 廣田 勇士

Research Projects

Research Products

Co-Researchers

CGMデータとAIを活用した糖尿病診療支援システムの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Search for the causative gene of genetic insulin resistance syndrome and analysis of the pathogenesis using patient iPS cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of the gene that causes insulin resistance syndrome using exome sequencing and iPS cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The impact of acute glycemic index on the outcome in septic patients with presence of diabetes.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research on new method for evaluating insulin secretion, and association with the genetic factorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] New classification and diagnostic criteria for insulin resistance syndrome.2022

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] New classification and diagnostic criteria for insulin resistance syndrome2022

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Treatment of a case of severe insulin resistance due to a PIK3R1 mutation with a sodium-glucose cotransporter-2 inhibitor.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] C-peptide response to glucagon challenge predicts improvement by liraglutide of both early insulin secretion and glucose tolerance2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Variations with modest effects have an important role in the genetic background of type 2 diabetes and diabetes-related traits2012

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] A Minimally Invasive System for Glucose Area under the Curve Measurement using Interstitial Fluid Extraction Technology: Evaluation of the Accuracy and Usefulness with OGTTs in Diabetic and Nondiabetic Subjects2012

Author(s)

Journal Title

Data Source

[Journal Article] Age-dependent decline in β-cell function assessed by an oral glucose tolerance test-based disposition index2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Age-dependent decline in β-cell function assessed by an oral glucose tolerance test-based disposition index

Author(s)

Journal Title

Data Source

[Patent] 糖尿病予防又は治療剤スクリーニング方法、及び当該方法に用いる細胞2018

Inventor(s)

Hirota Yushi 廣田勇士

HIROTA Yushi 廣田勇士