SEINO Shizuka 清野静香

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清野静香セイノシズカ

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Researcher Number	80571653
Affiliation (Current)	2025: 山形大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2010 – 2013: 山形大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Clinical oncology
Keywords	Principal Investigator 抗がん物質探索 / mitochondria / oxidative metabolism / cancer-initiating cells / 治療耐性 / 化学療法 / がん / ケミカルバイオロジー

An attempt to develop novel anti-cancer agents through fusion of the cancer stem cell hypothesis and mitochondrial metabolism studyPrincipal Investigator
- Principal Investigator
  
  SEINO Shizuka
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Clinical oncology
- Research Institution
  Yamagata University
Overcomingtherapy resistanceofintractable cancersviamodulation of mitochondrial energy metabolismPrincipal Investigator
- Principal Investigator
  
  SEINO Shizuka
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Clinical oncology
- Research Institution
  Yamagata University

All 2014 2013 2012 2011 2010

All Journal Article Presentation

[Journal Article] Pivotal role for ROS activation of p38 MAPK in the control of differentiation and tumor-initiating capacity of glioma-initiating cells2014
- Author(s)
  Sato A, Okada M, Shibuya K, Watanabe E, Seino S, Narita Y, Shibui S, Kayama T, Kitanaka C
- Journal Title
  
  Stem Cell Res
  
  Volume: 12 Pages: 119-131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650644
[Journal Article] JNK contributes to temozolomide resistance of stem-like glioblastoma cells via regulation of MGMT expression2014
- Author(s)
  Okada M, Sato A, Shibuya K, Watanabe E, Seino S, Suzuki S, Seino M, Narita Y, Shibui S, Kayama T, Kitanaka C
- Journal Title
  
  Int J Oncol
  
  Volume: 44 Pages: 591-599
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650644
[Journal Article] Resveratrol promotes proteasome-dependent degradation of Nanog via p53 activation and induces differentiation of glioma stem cells2013
- Author(s)
  Sato A, Okada M, Shibuya K, Watanabe E, Seino S, Suzuki K, Narita Y, Shibui S, Kayama T, Kitanaka C
- Journal Title
  
  Stem Cell Res
  
  Volume: 11 Pages: 601-610
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650644
[Journal Article] Specific role of JNK in the maintenance of the tumor-initiating capacity of A549 human non-small cell lung cancer cells2013
- Author(s)
  Okada M, Shibuya K, Sato A, Seino S, Watanabe E, Suzuki S, Seino M, Kitanaka C
- Journal Title
  
  Oncol Rep
  
  Volume: 30 Pages: 1957-1964
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650644
[Journal Article] Glioma-initiating cell elimination by metformin activation of FOXO3 via AMPK2012
- Author(s)
  Sato A, Sunayama J, Okada M, Watanabe E, Seino S, Shibuya K, Suzuki K, Narita Y, Shibui S, Kayama T, Kitanaka C
- Journal Title
  
  Stem Cells Transl Med
  
  Volume: 1 Pages: 811-824
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650644
[Journal Article] Targeting JNK for therapeutic depletion of stem-like glioblastoma cells2012
- Author(s)
  Matsuda K, Sato A, Okada M, Shibuya K, Seino S, Suzuki K, Watanabe E, Narita Y, Shibui S, Kayama T, Kitanaka C
- Journal Title
  
  Sci Rep
  
  Volume: 2 Issue: 1 Pages: 516-516
- DOI
  10.1038/srep00516
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650235, KAKENHI-PROJECT-22791745, KAKENHI-PROJECT-23791585, KAKENHI-PROJECT-24390338, KAKENHI-PROJECT-24650644
[Journal Article] Glioma-initiating cell elimination by metformin activation of FOXO3 via AMPK2012
- Author(s)
  Sato A, Sunayama J, Okada M, Watanabe E, Seino S, Shibuya K, Suzuki K, Narita Y, Shibui S, Kayama T, Kitanaka C
- Journal Title
  
  Stem Cells Transl Med
  
  Volume: 1 Pages: 811-824
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650235
[Journal Article] Targeting JNK for therapeutic depletion of stem-like glioblastoma cells2012
- Author(s)
  Matsuda K, Sato A, Okada M, Shibuya K, Seino S, Suzuki K, Watanabe E, Narita Y, Shibui S, Kayama T, Kitanaka C
- Journal Title
  
  Sci Rep
  
  Volume: 2 Pages: 516-516
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650644
[Journal Article] FoxO3a functions as a key integrator of cellular signals that control glioblastoma stem-like cell differentiation and tumorigenicity2011
- Author(s)
  Sunayama J, Sato A, Matsuda KI, Tachibana K, Watanabe E, Seino S, Suzuki K, Narita Y, Shibui S, Sakurada K, Kayama T, Tomiyama A, Kitanaka C
- Journal Title
  
  Stem Cells
  
  Volume: 29 Pages: 1327-1337
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650235
[Journal Article] MEK-ERK signaling dictates DNA-repair gene MGMT expression and temozolomide resistance of stem-like glioblastoma cells via the MDM2-p53 axis2011
- Author(s)
  Sato A, Sunayama J, Matsuda K, Seino S, Suzuki K, Watanabe E, Tachibana K, Tomiyama A, Kayama T, Kitanaka C
- Journal Title
  
  StemCells
  
  Volume: 29 Pages: 1942-1951
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650235
[Journal Article] MEK-ERK-dependent multiple caspase activation via mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation-induced glioma cell death2010
- Author(s)
  Tomiyama A, Tachibana K, Suzuki K, Seino S, Sunayama J, Matsuda KI, Sato A, Matsumoto Y, Nomiya T, Nemoto K, Yamashita H, Kayama T, Ando K, Kitanaka C
- Journal Title
  
  Cell Death Dis
  
  Volume: 1 Issue: 7 Pages: e60-e60
- DOI
  10.1038/cddis.2010.37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650235
[Presentation] レスベラトロールによるNanog-p53経路を介したグリオーマ幹細胞の制御2013
- Author(s)
  佐藤篤,岡田雅司,渋谷慶太,清野静香,成田善孝,渋井壮一郎,北中千史,嘉山孝正
- Organizer
  第14回日本分子脳神経外科学会
- Place of Presentation
  横浜(パシフィコ横浜)
- Year and Date
  2013-10-19
- Data Source
  KAKENHI-PROJECT-24650644
[Presentation] グリオーマ幹細胞における FoxO3aを介した分化と造腫瘍能の制御2011
- Author(s)
  佐藤篤,砂山潤,松田憲一朗,立花研,渡部江梨子,清野静香,鈴木香,成田善孝,渋井壮一郎,富山新太,北中千史,嘉山孝正
- Organizer
  第29回日本脳腫瘍学会学術総会
- Place of Presentation
  下呂(水明館)
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-22650235
[Presentation] グリオーマ幹細胞におけるMGMT発現制御の分子機構に関する検討2011
- Author(s)
  佐藤篤,松田憲一朗,砂山潤,清野静香,鈴木香,渡部江梨子,立花研,富山新太,北中千史,嘉山孝正
- Organizer
  第12回日本分子脳神経外科学会
- Place of Presentation
  横浜(パシフィコ横浜)
- Year and Date
  2011-10-15
- Data Source
  KAKENHI-PROJECT-22650235
[Presentation] MEK経路阻害によるMGMT発現およびテモゾロミド感受性に関する検討2011
- Author(s)
  佐藤篤,松田憲一朗,砂山潤,清野静香,鈴木香,櫻田香,立花研,富山新太,北中千史,嘉山孝正
- Organizer
  第70回日本脳神経外科学会総会
- Place of Presentation
  横浜(パシフィコ横浜)
- Year and Date
  2011-10-12
- Data Source
  KAKENHI-PROJECT-22650235
[Presentation] グリオーマ幹細胞におけるMGMT発現とテモゾロミド感受性に関する検討2010
- Author(s)
  佐藤篤,松田憲一朗,砂山潤,清野静香,鈴木香,櫻田香,立花研,富山新太,北中千史,嘉山孝正
- Organizer
  第28回日本脳腫瘍学会
- Place of Presentation
  軽井沢(軽井沢プリンスホテル)
- Year and Date
  2010-11-28
- Data Source
  KAKENHI-PROJECT-22650235

1. KITANAKA Chifumi (70260320)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
2. TOMIYAMA Arata (40385810)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
3. SATO Atsushi (30455901)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results

SEINO Shizuka 清野 静香

清野 静香 セイノ シズカ

Research Projects

Research Products

Co-Researchers

An attempt to develop novel anti-cancer agents through fusion of the cancer stem cell hypothesis and mitochondrial metabolism studyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Overcomingtherapy resistanceofintractable cancersviamodulation of mitochondrial energy metabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Pivotal role for ROS activation of p38 MAPK in the control of differentiation and tumor-initiating capacity of glioma-initiating cells2014

Author(s)

Journal Title

Data Source

[Journal Article] JNK contributes to temozolomide resistance of stem-like glioblastoma cells via regulation of MGMT expression2014

Author(s)

Journal Title

Data Source

[Journal Article] Resveratrol promotes proteasome-dependent degradation of Nanog via p53 activation and induces differentiation of glioma stem cells2013

Author(s)

Journal Title

Data Source

[Journal Article] Specific role of JNK in the maintenance of the tumor-initiating capacity of A549 human non-small cell lung cancer cells2013

Author(s)

Journal Title

Data Source

[Journal Article] Glioma-initiating cell elimination by metformin activation of FOXO3 via AMPK2012

Author(s)

Journal Title

Data Source

[Journal Article] Targeting JNK for therapeutic depletion of stem-like glioblastoma cells2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Glioma-initiating cell elimination by metformin activation of FOXO3 via AMPK2012

Author(s)

Journal Title

Data Source

[Journal Article] Targeting JNK for therapeutic depletion of stem-like glioblastoma cells2012

Author(s)

Journal Title

Data Source

[Journal Article] FoxO3a functions as a key integrator of cellular signals that control glioblastoma stem-like cell differentiation and tumorigenicity2011

Author(s)

Journal Title

Data Source

[Journal Article] MEK-ERK signaling dictates DNA-repair gene MGMT expression and temozolomide resistance of stem-like glioblastoma cells via the MDM2-p53 axis2011

Author(s)

Journal Title

Data Source

[Journal Article] MEK-ERK-dependent multiple caspase activation via mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation-induced glioma cell death2010

Author(s)

Journal Title

DOI

Data Source

[Presentation] レスベラトロールによるNanog-p53経路を介したグリオーマ幹細胞の制御2013

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] グリオーマ幹細胞における FoxO3aを介した分化と造腫瘍能の制御2011

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] グリオーマ幹細胞におけるMGMT発現制御の分子機構に関する検討2011

Author(s)

Organizer

Place of Presentation

Year and Date

SEINO Shizuka 清野静香

清野静香セイノシズカ