TSUBOI DAISUKE 坪井大輔

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TSUBOI Daisuke 坪井大輔

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Researcher Number	80584672
Other IDs
Affiliation (Current)	2025: 藤田医科大学, 医科学研究センター, 講師
Affiliation (based on the past Project Information) *help	2022 – 2024: 藤田医科大学, 医科学研究センター, 講師 2021: 藤田医科大学, 総合医科学研究所, 講師 2016 – 2017: 名古屋大学, 医学系研究科, 特任助教 2014: 名古屋大学, 医学(系)研究科(研究院), 特任助教 2012 – 2014: 名古屋大学, 医学(系)研究科(研究院), 助教 2012: 名古屋大学, 大学院・医学系研究科, 助教 2010 – 2011: 名古屋大学, 医学系研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 47040:Pharmacology-related / Basic Section 46030:Function of nervous system-related / Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology Except Principal Investigator Basic Section 46030:Function of nervous system-related / Cell biology
Keywords	Principal Investigator うつ病 / 脳回路活動 / タンパク質リン酸化 / 細胞内シグナル伝達 / 統合失調症 / イオンチャネル / シグナル伝達 / 情動 / 情動行動 / KCNQ2 … More / リン酸化 / カリウムチャネル / 報酬行動 / 電位依存性カリウムチャネル / サイトカイン / ミクログリア / DISC1 / シナプス可塑性 / 神経科学 … More Except Principal Investigator 学習 / 情動 / 全脳イメージング / リン酸化シグナル / ニューロモジュレーター / 小胞輸送 / 脳・神経 / 微小管 / プロテオーム / 極性 / 細胞骨格 / 遊走 / シグナル伝達 Less

ニューロモデュレーターとリン酸化シグナルによる情動と学習の制御機構の解明
- Principal Investigator
  
  貝淵弘三
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 46030:Function of nervous system-related
- Research Institution
  Fujita Health University
KCNQカリウムチャネルに着目したうつ病の神経・分子病態の解明Principal Investigator
- Principal Investigator
  
  坪井大輔
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Fujita Health University
KCNQカリウムチャネルが関わる情動行動の分子基盤解明Principal Investigator
- Principal Investigator
  
  坪井大輔
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46030:Function of nervous system-related
- Research Institution
  Fujita Health University
Role of Disrupted-In-Schizophrenia-1 on microgliaPrincipal Investigator
- Principal Investigator
  
  TSUBOI DAISUKE
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Nagoya University
Functional analysis of DISC1 using Disc1-knockout mousePrincipal Investigator
- Principal Investigator
  
  TSUBOI Daisuke
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Nagoya University
MOLECULAR MECHANISMS UNDERLYING CELL POLARIZATION IN MIGRATING CELLS AND NEURONS
- Principal Investigator
  
  KAIBUCHI Kozo
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Cell biology
- Research Institution
  Nagoya University

All 2024 2023 2022 2021 2015 2013 2012 2009 Other

All Journal Article Presentation Book Other

[Book] 実験医学2015年6月号2015
- Author(s)
  坪井大輔、森大輔、永井拓、山田清文、尾崎紀夫、貝淵弘三
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-24700377
[Journal Article] Neuromodulator regulation and emotions: insights from the crosstalk of cell signaling2024
- Author(s)
  Tsuboi D, Nagai T, Yoshimoto J, Kaibuchi K.
- Journal Title
  
  Front Mol Neurosci
  
  Volume: 17 Pages: 1376762-1376762
- DOI
  10.3389/fnmol.2024.1376762
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06427
[Journal Article] KANPHOS: Kinase-associated neural phospho-signaling database for data-driven research2024
- Author(s)
  Kannon T, Murashige S, Nishioka T, Amano M, Funahashi Y, Tsuboi D, Yamahashi Y, Nagai T, Kaibuchi K, Yoshimoto J.
- Journal Title
  
  Front Mol Neurosci
  
  Volume: 17 Pages: 1379089-1379089
- DOI
  10.3389/fnmol.2024.1379089
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06427, KAKENHI-PROJECT-21K06428
[Journal Article] Neuroproteomic mapping of kinases and their substrates downstream of acetylcholine: finding and implications2023
- Author(s)
  Yamahashi Y, Tsuboi D, Funahashi Y, Kaibuchi K.
- Journal Title
  
  Expert Rev Proteomics
  
  Volume: 20 Issue: 11 Pages: 291-298
- DOI
  10.1080/14789450.2023.2265067
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06427, KAKENHI-PROJECT-23K06173
[Journal Article] LIS1 RNA-binding orchestrates the mechanosensitive properties of embryonic stem cells in AGO2-dependent and independent ways2023
- Author(s)
  Kshirsagar A, Doroshev SM, Gorelik A, Olender T, Sapir T, Tsuboi D, Rosenhek-Goldian I, Malitsky S, Itkin M, Argoetti A, Mandel-Gutfreund Y, Cohen SR, Hanna JH, Ulitsky I, Kaibuchi K, Reiner O.
- Journal Title
  
  Nat Commun
  
  Volume: 14 Issue: 1 Pages: 3293-3293
- DOI
  10.1038/s41467-023-38797-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06427
[Journal Article] Phosphoproteomic of the acetylcholine pathway enables discovery of the PKC-β-PIX-Rac1-PAK cascade as a stimulatory signal for aversive learning2022
- Author(s)
  Yamahashi Y, Lin YH, Mouri A, Iwanaga S, Kawashima K, Tokumoto Y, Watanabe Y, Faruk MO, Zhang X, Tsuboi D, Nakano T, Saito N, Nagai T, Yamada K, Kaibuchi K.
- Journal Title
  
  Molecular Psychiatry
  
  Volume: 27 Issue: 8 Pages: 3479-3492
- DOI
  10.1038/s41380-022-01643-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06427, KAKENHI-PROJECT-20K07082, KAKENHI-PROJECT-20K07931, KAKENHI-PUBLICLY-21H00196
[Journal Article] Phosphorylation Signals Downstream of Dopamine Receptors in Emotional Behaviors: Association with Preference and Avoidance2022
- Author(s)
  Zhang X, Tsuboi D, Funahashi Y, Yamahashi Y, Kaibuchi K, Nagai T.
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 19 Pages: 11643-11643
- DOI
  10.3390/ijms231911643
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06427, KAKENHI-PROJECT-21K06428, KAKENHI-PUBLICLY-21H00196
[Journal Article] Dopamine drives neuronal excitability via KCNQ channel phosphorylation for reward behavior2022
- Author(s)
  Tsuboi Daisuke、Otsuka Takeshi、Shimomura Takushi、Faruk Md Omar、Yamahashi Yukie、Amano Mutsuki、Funahashi Yasuhiro、Kuroda Keisuke、Nishioka Tomoki、Kobayashi Kenta、Sano Hiromi、Nagai Taku、Yamada Kiyofumi、Tzingounis Anastasios V.、Nambu Atsushi、Kubo Yoshihiro、Kawaguchi Yasuo、Kaibuchi Kozo
- Journal Title
  
  Cell Reports
  
  Volume: 40 Issue: 10 Pages: 111309-111309
- DOI
  10.1016/j.celrep.2022.111309
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07965, KAKENHI-PROJECT-21K06427, KAKENHI-PROJECT-21K06428, KAKENHI-PROJECT-21K07257, KAKENHI-PROJECT-22K06438, KAKENHI-PROJECT-19KK0193, KAKENHI-PROJECT-20K07082, KAKENHI-PROJECT-20K07284, KAKENHI-PUBLICLY-21H00196, KAKENHI-PUBLICLY-22H04758, KAKENHI-PUBLICLY-22H04790, KAKENHI-PROJECT-20H03359
[Journal Article] Rho-Rho-Kinase Regulates Ras-ERK Signaling Through SynGAP1 for Dendritic Spine Morphology2022
- Author(s)
  Wu M, Funahashi Y, Takano T, Hossen E, Ahammad RU, Tsuboi D, Amano M, Yamada K, Kaibuchi K.
- Journal Title
  
  Neurochemical Research
  
  Volume: 47 Issue: 9 Pages: 2757-2772
- DOI
  10.1007/s11064-022-03623-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06427, KAKENHI-PROJECT-21K06428, KAKENHI-PROJECT-23K21346
[Journal Article] KANPHOS: A Database of Kinase-Associated Neural Protein Phosphorylation in the Brain2021
- Author(s)
  Ahammad Rijwan Uddin、Nishioka Tomoki、Yoshimoto Junichiro、Kannon Takayuki、Amano Mutsuki、Funahashi Yasuhiro、Tsuboi Daisuke、Faruk Md. Omar、Yamahashi Yukie、Yamada Kiyofumi、Nagai Taku、Kaibuchi Kozo
- Journal Title
  
  Cells
  
  Volume: 11 Issue: 1 Pages: 47-47
- DOI
  10.3390/cells11010047
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16370, KAKENHI-PUBLICLY-21H00196, KAKENHI-PROJECT-21K06427, KAKENHI-PROJECT-21K06428
[Journal Article] Muscarinic signaling regulates voltage‐gated potassium channel KCNQ2 phosphorylation in the nucleus accumbens via protein kinase C for aversive learning2021
- Author(s)
  Faruk Md. Omar、Tsuboi Daisuke、Yamahashi Yukie、Funahashi Yasuhiro、Lin You‐Hsin、Ahammad Rijwan Uddin、Hossen Emran、Amano Mutsuki、Nishioka Tomoki、Tzingounis Anastasios V、Yamada Kiyofumi、Nagai Taku、Kaibuchi Kozo
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 160 Issue: 3 Pages: 325-341
- DOI
  10.1111/jnc.15555
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16370, KAKENHI-PUBLICLY-21H00196, KAKENHI-PROJECT-21K06427, KAKENHI-PROJECT-21K06428, KAKENHI-PROJECT-20K07082
[Journal Article] Disrupted-in-schizophrenia 1 regulates transport of ITPR1 mRNA for synaptic plasticity.2015
- Author(s)
  Tsuboi D, Kuroda K, Tanaka M, Namba T, Iizuka Y, Taya S, Shinoda T, Hikita T, Muraoka S, Iizuka M, Nimura A, Mizoguchi A, Shiina N, Sokabe M, Okano H, Mikoshiba K, Kaibuchi K
- Journal Title
  
  Nature Neuroscience
  
  Volume: in press Issue: 5 Pages: 698-707
- DOI
  10.1038/nn.3984
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24700377, KAKENHI-PROJECT-25251021, KAKENHI-PROJECT-25830051, KAKENHI-PROJECT-15K06772, KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-25221002, KAKENHI-PROJECT-24247028, KAKENHI-PROJECT-25440099
[Journal Article] Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus.2009
- Author(s)
  Enomoto, A., Asai, N., Namba, T., Wang, Y., Kato, T., Tanaka, M., Tatsumi, H., Taya, S., Tsuboi, D., Kuroda, K., Kaneko, N., Sawamoto, K., Miyamoto, R., Jijiwa, M., Murakumo, Y., Sokabe, M., Seki, T., Kaibuchi, K., Takahashi, M.
- Journal Title
  
  Neuron 63
  
  Pages: 774-787
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20227006
[Presentation] リン酸化情報基盤データベースKANPHOSが紐解くドーパミンシグナル伝達の分子基盤2023
- Author(s)
  坪井大輔、大塚岳、下村拓、久保義弘、佐野裕美、南部篤、Anastasios V Tzingounis 、貝淵弘三
- Organizer
  Neuro2023
- Data Source
  KAKENHI-PROJECT-21K06427
[Presentation] Patho-physiological functions of DISC1, a susceptibility gene of schizophrenia2013
- Author(s)
  坪井大輔
- Organizer
  The 2nd Brain Deseases and Molecular Machines Conference
- Place of Presentation
  フランス大使館（東京都港区）
- Invited
- Data Source
  KAKENHI-PROJECT-24700377
[Presentation] 海馬神経細胞においてDISC1はIP3受容体mRNAの輸送を制御する2013
- Author(s)
  坪井大輔
- Organizer
  第３６回日本神経科学大会
- Place of Presentation
  国立京都国際会館（京都市）
- Data Source
  KAKENHI-PROJECT-24700377
[Presentation] Disrupted-In-Schizoprenia-1 regulates transport of neuronal mRNA.2012
- Author(s)
  Tsuboi, D., Kuroda, K., Iizuka, Y., Okano, H., Mikoshiba, K., and Kaibuchi, K
- Organizer
  The 42nd Annual Meeting the Society for Neuroscience Society
- Place of Presentation
  ニューオリンズ、アメリカ
- Data Source
  KAKENHI-PROJECT-24700377
[Presentation] プロテオミクスから見た統合失調症の病態生理2012
- Author(s)
  坪井大輔
- Organizer
  第１０回日本プロテオーム学会
- Place of Presentation
  日本科学未来館、東京
- Invited
- Data Source
  KAKENHI-PROJECT-24700377
[]

1. KAIBUCHI Kozo (00169377)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
2. AMANO Mutsuki (90304170)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. WATANABE Takashi (10402562)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. MORI Daisuke (00381997)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. NISHIOKA Tomoki (70435105)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. ARIMURA Nariko (20420375)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 船橋靖広 (00749913)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 山橋幸恵 (00793481)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. 黒田啓介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TSUBOI DAISUKE 坪井 大輔

TSUBOI Daisuke 坪井 大輔

Research Projects

Research Products

Co-Researchers

ニューロモデュレーターとリン酸化シグナルによる情動と学習の制御機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

KCNQカリウムチャネルに着目したうつ病の神経・分子病態の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

KCNQカリウムチャネルが関わる情動行動の分子基盤解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of Disrupted-In-Schizophrenia-1 on microgliaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis of DISC1 using Disc1-knockout mousePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

MOLECULAR MECHANISMS UNDERLYING CELL POLARIZATION IN MIGRATING CELLS AND NEURONS

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 実験医学2015年6月号2015

Author(s)

Publisher

Data Source

[Journal Article] Neuromodulator regulation and emotions: insights from the crosstalk of cell signaling2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] KANPHOS: Kinase-associated neural phospho-signaling database for data-driven research2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Neuroproteomic mapping of kinases and their substrates downstream of acetylcholine: finding and implications2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] LIS1 RNA-binding orchestrates the mechanosensitive properties of embryonic stem cells in AGO2-dependent and independent ways2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phosphoproteomic of the acetylcholine pathway enables discovery of the PKC-β-PIX-Rac1-PAK cascade as a stimulatory signal for aversive learning2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phosphorylation Signals Downstream of Dopamine Receptors in Emotional Behaviors: Association with Preference and Avoidance2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dopamine drives neuronal excitability via KCNQ channel phosphorylation for reward behavior2022

Author(s)

Journal Title

DOI

Data Source

TSUBOI DAISUKE 坪井大輔

TSUBOI Daisuke 坪井大輔

[Presentation] リン酸化情報基盤データベースKANPHOSが紐解くドーパミンシグナル伝達の分子基盤2023