Takagi Miyuki 高木美幸

… Alternative Names

TAKAGI Miyuki 高木美幸

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Researcher Number	80599895
Affiliation (Current)	2025: 順天堂大学, 医学部, 特任助教
Affiliation (based on the past Project Information) *help	2021 – 2024: 順天堂大学, 医学部, 特任助教 2017 – 2018: 順天堂大学, 医学部, 特任助教 2015 – 2016: 順天堂大学, 医学部, 助教 2013 – 2014: 順天堂大学, 医学部, 非常勤助教 2012: 順天堂大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 53040:Nephrology-related / Kidney internal medicine
Keywords	Principal Investigator 糸球体硬化 / Array tomography / IgA腎症 / 蛋白尿 / カテプシンD / カテプシンL / オートファジー / ポドサイト / ポドサイトパチー / 糸球体上皮細胞 … More / grouped ddyマウス / 馬杉腎炎モデル / Array Tomography（AT) / FIB-SEM / Array Tomography法 / 血尿 / エンドサイトーシス / ポドシン / アドリアマイシン / Rac1 / 細胞骨格 / Sal1 / ポドサイト剥離 / シナプトポディン / ネフローゼ / カテプシン / オートファジーリソソーム分解系 / カテプシンＬ Less

Array tomographyによる糸球体硬化過程の解明Principal Investigator
- Principal Investigator
  
  高木美幸
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Juntendo University
Establishing a morphological mechanism of hematuria in IgA nephropathy. -Aiming to Promote Precise and Specific Therapeutic Interventions-Principal Investigator
- Principal Investigator
  
  Takagi Miyuki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Juntendo University
Research into the relationship between autophagy lysosome degradation factors and glomerulosclerosis leading to development of new medical treatment options.Principal Investigator
- Principal Investigator
  
  TAKAGI Miyuki
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Juntendo University
The role of lysosomal proteases in podocytesPrincipal Investigator
- Principal Investigator
  
  TAKAGI Miyuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Juntendo University

All 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Rac1 in podocytes promotes glomerular repair and limits the formation of sclerosis2018
- Author(s)
  Asao Rin、Seki Takuto、Takagi Miyuki、Yamada Hiroyuki、Kodama Fumiko、Hosoe-Nagai Yoshiko、Tanaka Eriko、Trejo Juan Alejandro Oliva、Yamamoto-Nonaka Kanae、Sasaki Yu、Hidaka Teruo、Ueno Takashi、Yanagita Motoko、Suzuki Yusuke、Tomino Yasuhiko、Asanuma Katsuhiko
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 5061-5061
- DOI
  10.1038/s41598-018-23278-6
- NAID
  120006517798
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19466, KAKENHI-PROJECT-18K16008, KAKENHI-PUBLICLY-17H05642, KAKENHI-PUBLICLY-18H04673, KAKENHI-PROJECT-17K19677, KAKENHI-PROJECT-18H02823, KAKENHI-PROJECT-17K19653
[Journal Article] Expression of Cathepsin L and Its Intrinsic Inhibitors in Glomeruli of Rats With Puromycin Aminonucleoside Nephrosis2018
- Author(s)
  Kubo Ayano、Shirato Isao、Hidaka Teruo、Takagi Miyuki、Sasaki Yu、Asanuma Katsuhiko、Ishidoh Kazumi、Suzuki Yusuke
- Journal Title
  
  Journal of Histochemistry & Cytochemistry
  
  Volume: 66 Issue: 12 Pages: 863-877
- DOI
  10.1369/0022155418791822
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16008, KAKENHI-PROJECT-15K19466, KAKENHI-PROJECT-18H02823, KAKENHI-PROJECT-17K19653
[Journal Article] Neurofilament heavy polypeptide protects against reduction in synaptopodin expression and prevents podocyte detachment2018
- Author(s)
  Wang Juan、Hidaka Teruo、Sasaki Yu、Tanaka Eriko、Takagi Miyuki、Shibata Terumi、Kubo Ayano、Trejo Juan Alejandro Oliva、Wang Lining、Asanuma Katsuhiko、Tomino Yasuhiko
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 17157-17171
- DOI
  10.1038/s41598-018-35465-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16008, KAKENHI-PROJECT-15K19466, KAKENHI-PROJECT-18H02823, KAKENHI-PROJECT-17K19653
[Journal Article] Re-expression of Sall1 in podocytes protects against adriamycin-induced nephrosis2017
- Author(s)
  Hosoe-Nagai Yoshiko、Hidaka Teruo、Sonoda Ayano、Sasaki Yu、Yamamoto-Nonaka Kanae、Seki Takuto、Asao Rin、Tanaka Eriko、Trejo Juan Alejandro Oliva、Kodama Fumiko、Takagi Miyuki、Tada Nobuhiro、Ueno Takashi、Nishinakamura Ryuichi、Tomino Yasuhiko、Asanuma Katsuhiko
- Journal Title
  
  Laboratory Investigation
  
  Volume: 97 Issue: 11 Pages: 1306-1320
- DOI
  10.1038/labinvest.2017.69
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19466, KAKENHI-PROJECT-17K19653
[Journal Article] Sorting Nexin 9 facilitates podocin endocytosis in the injured podocyte.2017
- Author(s)
  Sasaki Y, Hidaka T, Ueno T, Akiba-Takagi M, Trejo JA, Seki T, Nagai-Hosoe Y, Tanaka E, Horikoshi S, Tomino Y, Suzuki Y, Asanuma K.
- Journal Title
  
  10.1038/srep43921.2017
  
  Volume: 7 Issue: 1 Pages: 43921-43921
- DOI
  10.1038/srep43921
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670431, KAKENHI-PROJECT-15K19466, KAKENHI-PROJECT-17K19653
[Journal Article] Cathepsin D in Podocytes Is Important in the Pathogenesis of Proteinuria and CKD2016
- Author(s)
  Yamamoto-Nonaka K, Koike M, Asanuma K, Takagi M, Oliva Trejo JA, Seki T, Hidaka T, Ichimura K, Sakai T, Tada N, Ueno T, Uchiyama Y, Tomino Y
- Journal Title
  
  jornal of American Society of Nephrology
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19466
[Journal Article] Newly identified molecules related to podocyte injury induced by Adriamycin2015
- Author(s)
  Wang J, Asanuma K, Hidaka T, Sasaki Y, Tanaka E, Takagi-Akiba E, Oliva Trejo J.A, and Tomino Y
- Journal Title
  
  Juntendo Medical Journal
  
  Volume: 61 Pages: 34-40
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K19466
[Journal Article] Podocin is translocated to cytoplasm in puromycin aminonucleoside nephrosis rats and in poor-prognosis patients with IgA nephropathy.2015
- Author(s)
  Fukuda H, Hidaka T, Takagi-Akiba M, Ichimura K, Trejo JA, Sasaki Y, Wang J, Sakai T, Asanuma K, Tomino Y.
- Journal Title
  
  Cell & Tissue Research
  
  Volume: 360(2) Issue: 2 Pages: 391-400
- DOI
  10.1007/s00441-014-2100-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24790856, KAKENHI-PROJECT-15K18960, KAKENHI-PROJECT-15K19466
[Journal Article] Combination therapy with telmisartan and oxacalcitriol suppresses the progression of murine adriamycin nephropathy.2015
- Author(s)
  Jeong KH, Asanuma K, Lydia A, Takagi M, Asao R, Kodama F, Asanuma E, Tomino Y.
- Journal Title
  
  Nephron
  
  Volume: 129(2) Issue: 2 Pages: 143-154
- DOI
  10.1159/000369346
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24790856, KAKENHI-PROJECT-24790858, KAKENHI-PROJECT-26670431
[Journal Article] Podocyte-specific deletion of Rac1 leads to aggravation of renal injury in STZ-induced diabetic mice2015
- Author(s)
  Masanori Ishizaka, Tomohito Gohda, Miyuki Takagi, Keisuke Omote, Yuji Sonoda, Juan Alejandro Oliva Trejo, Rin Asao, Teruo Hidaka, Katsuhiko Asanuma, Satoshi Horikoshi, Yasuhiko Tomino
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 467 Issue: 3 Pages: 549-555
- DOI
  10.1016/j.bbrc.2015.09.158
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461239, KAKENHI-PROJECT-26670431, KAKENHI-PROJECT-15K19466
[Journal Article] Notch2 activation ameliorates nephrosis.2014
- Author(s)
  Tanaka E, Asanuma K, Kim E, Sasaki Y, Oliva Trejo JA, Seki T, Nonaka K, Asao R, Nagai-Hosoe Y, Akiba-Takagi M, Hidaka T, Takagi M, Koyanagi A, Mizutani S, Yagita H, Tomino Y.
- Journal Title
  
  Nature communications
  
  Volume: 5 Issue: 1 Pages: 3296-3296
- DOI
  10.1038/ncomms4296
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-14J12268, KAKENHI-PROJECT-23591201, KAKENHI-PROJECT-24790856, KAKENHI-PROJECT-26860648
[Journal Article] Transient increase in proteinuria, poly-ubiquitylated proteins and ER stress markers in podocyte-specific autophagy-deficient mice following unilateral nephrectomy.2014
- Author(s)
  Oliva Trejo JA, Asanuma K, Kim EH, Takagi-Akiba M, Nonaka K, Hidaka T, Komatsu M, Tada N, Ueno T, Tomino Y.
- Journal Title
  
  Biochemical and biophysical research communications
  
  Volume: 446(4) Issue: 4 Pages: 1190-1196
- DOI
  10.1016/j.bbrc.2014.03.088
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-14J12268, KAKENHI-PROJECT-23591201, KAKENHI-PROJECT-24790856, KAKENHI-PLANNED-25111006
[Journal Article] Translocation of dendrin to the podocyte nucleus in acute glomerular injury in patients with IgA nephropathy.2013
- Author(s)
  Kodama F, Asanuma K, Takagi M, Hidaka T, Asanuma E, Fukuda H, Seki T, Takeda Y, Hosoe-Nagai Y, Asao R, Horikoshi S, Tomino Y.
- Journal Title
  
  Nephrology Dialysis Transplantation.
  
  Volume: 28 Issue: 7 Pages: 1762-1772
- DOI
  10.1093/ndt/gfs500
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790856, KAKENHI-PROJECT-24790858
[Journal Article] Translocation of dendrin to the podocyte nucleus in acute glomerular injury in patients with IgA nephropathy.2013
- Author(s)
  Kodama F, Asanuma K, Takagi M, Hidaka T, Asanuma E, Fukuda H, Seki T, Takeda Y, Hosoe-Nagai Y, Asao R, Horikoshi S, Tomino Y.
- Journal Title
  
  Nephrol Dial Transplant.
  
  Volume: 28(7) Pages: 1762-1772
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790856
[Journal Article] Clinical nephrology　糸球体障害足細胞障害とオートファジー2013
- Author(s)
  淺沼克彦, 日高輝夫, 高木美幸, 富野康日己
- Journal Title
  
  Annual Review腎臓
  
  Volume: 2013 Pages: 165-171
- Data Source
  KAKENHI-PROJECT-24790856
[Journal Article] Relationships between levels of urinary podocalyxin, number of urinary podocytes, and histologic injury in adult patients with IgA nephropathy.2012
- Author(s)
  Asao R, Asanuma K, Kodama F, Akiba-Takagi M, Nagai-Hosoe Y, Seki T, Takeda Y, Ohsawa I, Mano S, Matsuoka K, Kurosawa H, Ogasawara S, Hirayama Y, Sekine S, Horikoshi S, Hara M, Tomino Y.
- Journal Title
  
  Clin J Am Soc Nephrol.
  
  Volume: 7(9) Issue: 9 Pages: 1385-1393
- DOI
  10.2215/cjn.08110811
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790856
[Presentation] Toll-like receptor 8 and 10 are possibly associated with pathogenic mechanisms of idiopathic nephrotic syndrome.2017
- Author(s)
  Eriko Tanaka and Miyuki Takagi
- Organizer
  American Society of Nephrology Kidney Week 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19466
[Presentation] Notch2 pathway reactivation ameliorates urinary protein and glomerular sclerosis in adriamycin nephropathy mice.
- Author(s)
  Eriko Tanaka, Katsuhiko Asanuma, Kanae Nonaka, Takuto Seki, Rin Asao, Yoshiko Hosoe, Miyuki Takagi, Alejandro Oliva, Shuki Mizutani, Hideo Yagita, Yasuhiko Tomino.
- Organizer
  The 9th international podocyte conference
- Place of Presentation
  マイアミ
- Data Source
  KAKENHI-PROJECT-24790856
[Presentation] Relationship between Urinary Podocalyxin Level and Histological Activity in Patients with IgA Nephropathy.
- Author(s)
  Rin Asao, Katsuhiko Asanuma, Miyuki Takagi, Hiroyuki Kurosawa, Shinya Ogasawara, Yoshiaki Hirayama, Satoshi, Sakari Sekine, Satoshi Horikoshi, Masanori Hara, Yasuhiko Tomino.
- Organizer
  The 9th international podocyte conference
- Place of Presentation
  マイアミ
- Data Source
  KAKENHI-PROJECT-24790856
[Presentation] RIL(Reversion-induced LIM protein)のポドサイトにおける機能の検討
- Author(s)
  田中絵里子, 淺沼克彦, 児玉史子, 高木美幸, 日高輝夫, Peter Mundel, 水谷修紀, 富野康日己
- Organizer
  日本腎臓学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Year and Date
  2014-07-04 – 2014-07-06
- Data Source
  KAKENHI-PROJECT-24790856
[Presentation] ポドサイト障害におけるNotch再活性化とreceptor特異的糸球体硬化抑制機能の検討.
- Author(s)
  田中絵里子, 淺沼克彦, 関卓人, 野中香苗, 浅尾りん, 細江佳子, 高木美幸, 水谷修紀, 八木田秀雄, 富野康日己.
- Organizer
  第55回日本腎臓学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24790856
[Presentation] Effects of 22-oxa-calcitriol on podocyte injury in adriamycin-induced nephrosis.
- Author(s)
  Lidia Aida, 淺沼克彦, 野中香苗, 高木美幸, 富野康日己.
- Organizer
  第55回日本腎臓学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24790856

1. 鈴木祐介 (70372935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 角田宗一郎 (80551209)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 宮木貴之 (10967730)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. ASANUMA Katsuhiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. ISHIZAKA Masanori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 佐々木有

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 合田朋仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takagi Miyuki 高木 美幸

TAKAGI Miyuki 高木 美幸

Research Projects

Research Products

Co-Researchers

Array tomographyによる糸球体硬化過程の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishing a morphological mechanism of hematuria in IgA nephropathy. -Aiming to Promote Precise and Specific Therapeutic Interventions-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research into the relationship between autophagy lysosome degradation factors and glomerulosclerosis leading to development of new medical treatment options.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of lysosomal proteases in podocytesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Rac1 in podocytes promotes glomerular repair and limits the formation of sclerosis2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Expression of Cathepsin L and Its Intrinsic Inhibitors in Glomeruli of Rats With Puromycin Aminonucleoside Nephrosis2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Neurofilament heavy polypeptide protects against reduction in synaptopodin expression and prevents podocyte detachment2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Re-expression of Sall1 in podocytes protects against adriamycin-induced nephrosis2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sorting Nexin 9 facilitates podocin endocytosis in the injured podocyte.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cathepsin D in Podocytes Is Important in the Pathogenesis of Proteinuria and CKD2016

Author(s)

Journal Title

Data Source

[Journal Article] Newly identified molecules related to podocyte injury induced by Adriamycin2015

Author(s)

Journal Title

Data Source

[Journal Article] Podocin is translocated to cytoplasm in puromycin aminonucleoside nephrosis rats and in poor-prognosis patients with IgA nephropathy.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Combination therapy with telmisartan and oxacalcitriol suppresses the progression of murine adriamycin nephropathy.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Podocyte-specific deletion of Rac1 leads to aggravation of renal injury in STZ-induced diabetic mice2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Notch2 activation ameliorates nephrosis.2014

Author(s)

Takagi Miyuki 高木美幸

TAKAGI Miyuki 高木美幸

[Journal Article] Clinical nephrology　糸球体障害足細胞障害とオートファジー2013