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OZAWA Manabu  小沢 学

Researcher Number 80608787
Other IDs
  • ORCIDhttps://orcid.org/0000-0003-3284-7161
Affiliation (Current) 2025: 東京大学, 医科学研究所, 准教授
Affiliation (based on the past Project Information) *help 2016 – 2024: 東京大学, 医科学研究所, 准教授
2012 – 2015: 東京大学, 医科学研究所, 助教
2011: 東京大学, 医科学研究所, 特任助教
Review Section/Research Field
Principal Investigator
Basic Section 42030:Animal life science-related / Laboratory animal science / General physiology / Developmental biology
Except Principal Investigator
Basic Section 50020:Tumor diagnostics and therapeutics-related / Broad Section F
Keywords
Principal Investigator
精子形成 / 精巣 / エピジェネティクス / セルトリ細胞 / ヒストン / 精原幹細胞 / 精原細胞 / 減数分裂 / 精子 / 生殖細胞 … More / ゲノム編集 / マウス / 精細胞 / 選択的スプライシング / 細胞・組織 / 発生・分化 / 制限幹細胞 / 細胞周期 … More
Except Principal Investigator
転写調節 / 大腸がん / ブロモドメイン / エピジェネティックリーダー / 受精 / 精子 / 不妊 / ゲノム編集 / 実験動物 Less
  • Research Projects

    (8 results)
  • Research Products

    (67 results)
  • Co-Researchers

    (10 People)
  •  Development of novel cancer therapy based on the characteristics of epigenetic leaders that are upregulated in tumors

    • Principal Investigator
      山口 貴世志
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      The University of Tokyo
  •  セルトリ細胞はどのような分子経路を介して精細胞の減数分裂を制御するのか?Principal Investigator

    • Principal Investigator
      小沢 学
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 42030:Animal life science-related
    • Research Institution
      The University of Tokyo
  •  Development of male infertile model mice by genome editing and comprehensive study of fertilization

    • Principal Investigator
      伊川 正人
    • Project Period (FY)
      2021 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Review Section
      Broad Section F
    • Research Institution
      Osaka University
  •  PTBP1 contributes to spermatogenesis through regulation of meiosis of testicular germ cellsPrincipal Investigator

    • Principal Investigator
      Ozawa Manabu
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 42030:Animal life science-related
    • Research Institution
      The University of Tokyo
  •  Histone modifications in regulating the balance between self-renewal and differentiation of spermatogoniaPrincipal Investigator

    • Principal Investigator
      Ozawa Manabu
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory animal science
    • Research Institution
      The University of Tokyo
  •  The histone demethylase KDM2A regulates differentiation of spermatogonia in mice.Principal Investigator

    • Principal Investigator
      Ozawa Manabu
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Laboratory animal science
    • Research Institution
      The University of Tokyo
  •  The histone demethylase FBXL10 regulates the proliferation of spermatogonia and ensures long-term sustainable spermatogenesis in micePrincipal Investigator

    • Principal Investigator
      Manabu Ozawa
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General physiology
    • Research Institution
      The University of Tokyo
  •  Histone demethylas Fbxl10 regulates sustainable spermatogenesis in mice.Principal Investigator

    • Principal Investigator
      OZAWA Manabu
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Developmental biology
    • Research Institution
      The University of Tokyo

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Book Patent

  • [Book] Genome Editing in Animals2023

    • Author(s)
      Manabu Ozawa, Chihiro Emori, Masahito Ikawa
    • Total Pages
      399
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-20H03162
  • [Journal Article] Tex46 knockout male mice are sterile secondary to sperm head malformations and failure to penetrate through the zona pellucida2024

    • Author(s)
      Fujihara Y、Miyata H、Abbasi F、Larasati T、Nozawa K、Yu Z、Ikawa M、Matzuk MM.
    • Journal Title

      PNAS Nexus

      Volume: 3 Issue: 3 Pages: 108-108

    • DOI

      10.1093/pnasnexus/pgae108

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20KK0155, KAKENHI-PLANNED-19H05750, KAKENHI-PROJECT-21H05033, KAKENHI-PROJECT-21H02397
  • [Journal Article] Affinity-tagged SMAD1 and SMAD5 mouse lines reveal transcriptional reprogramming mechanisms during early pregnancy2024

    • Author(s)
      Liao Zian、Tang Suni、Nozawa Kaori、Shimada Keisuke、Ikawa Masahito、Monsivais Diana、Matzuk Martin
    • Journal Title

      eLife

      Volume: 12

    • DOI

      10.7554/elife.91434

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H05033
  • [Journal Article] Calcium-binding protein 7 expressed in muscle negatively regulates age-related degeneration of neuromuscular junctions in mice2024

    • Author(s)
      Eguchi Takahiro、Tezuka Tohru、Watanabe Yuji、Inoue-Yamauchi Akane、Sagara Hiroshi、Ozawa Manabu、Yamanashi Yuji
    • Journal Title

      iScience

      Volume: 27 Issue: 2 Pages: 108997-108997

    • DOI

      10.1016/j.isci.2024.108997

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K14459, KAKENHI-PROJECT-20H03162, KAKENHI-PROJECT-23K27084
  • [Journal Article] Multiple ageing effects on testicular/epididymal germ cells lead to decreased male fertility in mice2024

    • Author(s)
      Tsutomu Endo, Kiyonori Kobayashi, Takafumi Matsumura, Chihiro Emori, Manabu Ozawa, Shimpei Kawamoto, Daisuke Okuzaki, Keisuke Shimada, Haruhiko Miyata, Kentaro Shimada, Mayo Kodani, Yu Ishikawa-Yamauchi, Daisuke Motooka, Eiji Hara, Masahito Ikawa
    • Journal Title

      Communications Biology

      Volume: 7(1) Issue: 1 Pages: 1-6

    • DOI

      10.1038/s42003-023-05685-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K14456, KAKENHI-PROJECT-23K20043, KAKENHI-PROJECT-23K05587, KAKENHI-PROJECT-23K06481, KAKENHI-PROJECT-20H03162, KAKENHI-PLANNED-19H05750, KAKENHI-PROJECT-21H05033, KAKENHI-PROJECT-23K27084
  • [Journal Article] CUB domains are not required for OVCH2 function in sperm maturation in the mouse epididymis2023

    • Author(s)
      Kent Katarzyna、Nozawa Kaori、Sutton Courtney、Daniel Frey、Ikawa Masahito、Garcia Thomas X.、Matzuk Martin M.
    • Journal Title

      Andrology

      Volume: 12 Issue: 3 Pages: 682-697

    • DOI

      10.1111/andr.13508

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H05033
  • [Journal Article] Ptbp1 deletion does not induce astrocyte-to-neuron conversion2023

    • Author(s)
      Hoang Thanh、Kim Dong Won、Appel Haley、Ozawa Manabu、Zheng Sika、Kim Juhyun、Blackshaw Seth
    • Journal Title

      Nature

      Volume: 618 Issue: 7964 Pages: E1-E7

    • DOI

      10.1038/s41586-023-06066-9

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03162, KAKENHI-PROJECT-23K27084
  • [Journal Article] Molecular dissection and testing of PRSS37 function through LC?MS/MS and the generation of a PRSS37 humanized mouse model2023

    • Author(s)
      Sutton Courtney、Nozawa Kaori、Kent Katarzyna、Saltzman Alexander、Leng Mei、Nagarajan Sureshbabu、Malovannaya Anna、Ikawa Masahito、Garcia Thomas X.、Matzuk Martin M.
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 11374-11374

    • DOI

      10.1038/s41598-023-37700-1

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H05033
  • [Journal Article] Oocyte-specific Wee1-like protein kinase 2 is dispensable for fertility in mice2023

    • Author(s)
      Nozawa Kaori、Liao Zian、Satouh Yuhkoh、Geng Ting、Ikawa Masahito、Monsivais Diana、Matzuk Martin M.
    • Journal Title

      PLOS ONE

      Volume: 18 Issue: 8 Pages: e0289083-e0289083

    • DOI

      10.1371/journal.pone.0289083

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H05033
  • [Journal Article] Age-related decline in spermatogenic activity accompanied with endothelial cell senescence in male mice_2023

    • Author(s)
      Manabu Ozawa, Hideto Mori, Tsutomu Endo, Yu Ishikawa-Yamauchi, Daisuke Motooka, Chihiro Emori, Masahiro Ikawa
    • Journal Title

      iScience_

      Volume: 26(12) Issue: 12 Pages: 108456-108456

    • DOI

      10.1016/j.isci.2023.108456

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K14456, KAKENHI-PROJECT-23K05587, KAKENHI-PROJECT-20H03162, KAKENHI-PROJECT-21H05033, KAKENHI-PROJECT-23K27084
  • [Journal Article] Splice factor polypyrimidine tract-binding protein 1 (Ptbp1) primes endothelial inflammation in atherogenic disturbed flow conditions2022

    • Author(s)
      Hensel Jessica A.、Nicholas Sarah-Anne E.、Kimble Amy L.、Nagpal Arjun S.、Omar Omar M. F.、Tyburski Jordan D.、Jellison Evan R.、Menoret Antoine、Ozawa Manabu、Rodriguez-Oquendo Annabelle、Vella Anthony T.、Murphy Patrick A.
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 119 Issue: 30

    • DOI

      10.1073/pnas.2122227119

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03162
  • [Journal Article] CRISPR/Cas9-Mediated Highly Efficient Gene Targeting in Embryonic Stem Cells for Developing Gene-Manipulated Mouse Models2022

    • Author(s)
      Ozawa Manabu、Emori Chihiro、Ikawa Masahito
    • Journal Title

      Journal of Visualized Experiments

      Volume: 186 Issue: 186 Pages: 1-13

    • DOI

      10.3791/64385

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21H05033, KAKENHI-PROJECT-20H03162, KAKENHI-PLANNED-19H05750
  • [Journal Article] Genetic loss of function of Ptbp1 does not induce glia-to-neuron conversion in retina2022

    • Author(s)
      Hoang Thanh、Kim Dong Won、Appel Haley、Pannullo Nicole A.、Leavey Patrick、Ozawa Manabu、Zheng Sika、Yu Minzhong、Peachey Neal S.、Blackshaw Seth
    • Journal Title

      Cell Reports

      Volume: 39 Issue: 11 Pages: 110849-110849

    • DOI

      10.1016/j.celrep.2022.110849

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03162
  • [Journal Article] Efficient simultaneous double DNA knock-in in murine embryonic stem cells by CRISPR/Cas9 ribonucleoprotein-mediated circular plasmid targeting for generating gene-manipulated mice2022

    • Author(s)
      Ozawa Manabu、Taguchi Jumpei、Katsuma Kento、Ishikawa-Yamauchi Yu、Kikuchi Mio、Sakamoto Reiko、Yamada Yasuhiro、Ikawa Masahito
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 21558-21558

    • DOI

      10.1038/s41598-022-26107-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21H05033, KAKENHI-PROJECT-20H03162
  • [Journal Article] Generation of mice for evaluating endogenous p16Ink4a protein expression2022

    • Author(s)
      Shimada-Takayama Yui、Yasuda Takayuki、Ukai Tomoyo、Taguchi Jumpei、Ozawa Manabu、Sankoda Nao、Ohta Sho、Yamada Yasuhiro
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 599 Pages: 43-50

    • DOI

      10.1016/j.bbrc.2022.02.005

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-20H05384, KAKENHI-PROJECT-20H03162
  • [Journal Article] MYCL-mediated reprogramming expands pancreatic insulin-producing cells2022

    • Author(s)
      Hirano Michitada、So Yusei、Tsunekawa Shin、Kabata Mio、Ohta Sho、Sagara Hiroshi、Sankoda Nao、Taguchi Jumpei、Yamada Yosuke、Ukai Tomoyo、Kato Makoto、Nakamura Jiro、Ozawa Manabu、Yamamoto Takuya、Yamada Yasuhiro
    • Journal Title

      Nature Metabolism

      Volume: 4 Issue: 2 Pages: 254-268

    • DOI

      10.1038/s42255-022-00530-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-20H05384, KAKENHI-PROJECT-20H03162
  • [Journal Article] Skewed endosomal RNA responses from TLR7 to TLR3 in RNase T2-deficient macrophages2021

    • Author(s)
      Liu Kaiwen、Sato Ryota、Shibata Takuma、Hiranuma Ryosuke、Reuter Tatjana、Fukui Ryutaro、Zhang Yun、Ichinohe Takeshi、Ozawa Manabu、Yoshida Nobuaki、Latz Eicke、Miyake Kensuke
    • Journal Title

      International Immunology

      Volume: 33 Issue: 9 Pages: 479-490

    • DOI

      10.1093/intimm/dxab033

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03162, KAKENHI-PROJECT-21H04800, KAKENHI-PROJECT-20H03491, KAKENHI-PROJECT-21K15464, KAKENHI-PROJECT-16H06276
  • [Journal Article] DMRT1-mediated reprogramming drives development of cancer resembling human germ cell tumors with features of totipotency2021

    • Author(s)
      Taguchi Jumpei、Shibata Hirofumi、Kabata Mio、Kato Masaki、Fukuda Kei、Tanaka Akito、Ohta Sho、Ukai Tomoyo、Mitsunaga Kanae、Yamada Yosuke、Nagaoka So I、Yamazawa Sho、Ohnishi Kotaro、Woltjen Knut、Ushiku Tetsuo、Ozawa Manabu、Saitou Mitinori、Shinkai Yoichi、Yamamoto Takuya、Yamada Yasuhiro
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 5041-5041

    • DOI

      10.1038/s41467-021-25249-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K21352, KAKENHI-PROJECT-20H03162, KAKENHI-PLANNED-18H05530, KAKENHI-PUBLICLY-20H05384, KAKENHI-PROJECT-18H03991, KAKENHI-PROJECT-20K15801
  • [Journal Article] RNA-binding protein Ptbp1 regulates alternative splicing and transcriptome in spermatogonia and maintains spermatogenesis in concert with Nanos32020

    • Author(s)
      SENOO Manami、HOZOJI Hiroshi、ISHIKAWA-YAMAUCHI Yu、TAKIJIRI Takashi、OHTA Sho、UKAI Tomoyo、KABATA Mio、YAMAMOTO Takuya、YAMADA Yasuhiro、IKAWA Masahito、OZAWA Manabu
    • Journal Title

      J. Reprod. Dev.

      Volume: 66 Issue: 5 Pages: 459-467

    • DOI

      10.1262/jrd.2020-060

    • NAID

      130007925613

    • ISSN
      0916-8818, 1348-4400
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K16513, KAKENHI-PROJECT-19J01089, KAKENHI-PROJECT-17K07132
  • [Journal Article] NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility. Science.2020

    • Author(s)
      Kiyozumi D, Noda T, Yamaguchi R, Tobita T, Matsumura T, Shimada K, Kodani M, Kohda T, Fujihara Y, Ozawa M, Yu Z, Miklossy G, Bohren KM, Horie M, Okabe M, Matzuk MM, Ikawa M.
    • Journal Title

      Science.

      Volume: 368 Issue: 6495 Pages: 1132-1135

    • DOI

      10.1126/science.aay5134

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-19H05750, KAKENHI-PROJECT-17H01394, KAKENHI-PROJECT-17K07132, KAKENHI-PROJECT-20H03162, KAKENHI-ORGANIZER-19H05749
  • [Journal Article] Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo.2020

    • Author(s)
      Omori S, Wang TW, Johmura Y, ..., Sakamoto T (15番目), ..., Nakanishi M.
    • Journal Title

      Cell Metab

      Volume: 32 Issue: 5 Pages: 814-828

    • DOI

      10.1016/j.cmet.2020.09.006

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07659, KAKENHI-PROJECT-19K12215, KAKENHI-PROJECT-20K07563, KAKENHI-PROJECT-20K21497, KAKENHI-PROJECT-20K21612, KAKENHI-PROJECT-19KK0216, KAKENHI-PROJECT-17H06095, KAKENHI-PLANNED-17H06328, KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06392, KAKENHI-ORGANIZER-19H05739, KAKENHI-PLANNED-19H05740, KAKENHI-PUBLICLY-20H04940, KAKENHI-PUBLICLY-20H05025, KAKENHI-PROJECT-20H00567, KAKENHI-PROJECT-19H03413, KAKENHI-PROJECT-19H03431, KAKENHI-PROJECT-20H03707, KAKENHI-PROJECT-19J01606, KAKENHI-PROJECT-20J21945, KAKENHI-PROJECT-17K07132, KAKENHI-PROJECT-18K15826, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-18K06024, KAKENHI-PROJECT-20H03162, KAKENHI-PROJECT-20H03474
  • [Journal Article] PTBP1 contributes to spermatogenesis through regulation of proliferation in spermatogonia2019

    • Author(s)
      SENOO Manami、TAKIJIRI Takashi、YOSHIDA Nobuaki、OZAWA Manabu、IKAWA Masahito
    • Journal Title

      J. Reprod. Dev.

      Volume: 65 Issue: 1 Pages: 37-46

    • DOI

      10.1262/jrd.2018-109

    • NAID

      130007594357

    • ISSN
      0916-8818, 1348-4400
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07132, KAKENHI-PROJECT-17H01394
  • [Journal Article] Cell-type dependent enhancer binding of the EWS/ATF1 fusion gene in clear cell sarcomas2019

    • Author(s)
      Komura S, Ito Kenji、Ohta ShoUkai Tomoyo、Kabata Mio、Itakura Fumiaki、Semi Katsunori、Matsuda Yutaka、Hashimoto Kyoichi、Shibata Hirofumi、Sone Masamitsu、Jo Norihide、Sekiguchi Kazuya、Ohno Takatoshi、Akiyama Haruhiko、Shimizu Katsuji、Woltjen Knut、Ozawa Manabu、Toguchida Junya、Yamamoto Takuya、Yamada Yasuhiro
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 3999-3999

    • DOI

      10.1038/s41467-019-11745-1

    • NAID

      120006719352

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07132, KAKENHI-PROJECT-18H04026, KAKENHI-PROJECT-18H02929, KAKENHI-PROJECT-18K15210
  • [Journal Article] RNA-binding protein Ptbp1 is essential for BCR-mediated antibody production2018

    • Author(s)
      Sasanuma Hiroki、Ozawa Manabu、Yoshida Nobuaki
    • Journal Title

      International Immunology

      Volume: 31 Issue: 3 Pages: 157-166

    • DOI

      10.1093/intimm/dxy077

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07132
  • [Journal Article] WNT regulation of embryonic development likely involves pathways independent of nuclear CTNNB12017

    • Author(s)
      Tribulo Paula、Moss James I、Ozawa Manabu、Jiang Zongliang、Tian Xiuchun (Cindy)、Hansen Peter J
    • Journal Title

      Reproduction

      Volume: 153 Issue: 4 Pages: 405-419

    • DOI

      10.1530/rep-16-0610

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K07132, KAKENHI-PROJECT-15K18386, KAKENHI-PROJECT-16H06276
  • [Journal Article] The requirement for protein kinase C delta (PRKCD) during preimplantation bovine embryo development.2016

    • Author(s)
      Yang QE, Ozawa M, Zhang K, Johnson S, Ealy AD.
    • Journal Title

      Reproduction, Fertility and Development

      Volume: 28 Issue: 4 Pages: 482-490

    • DOI

      10.1071/rd14160

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K18386
  • [Journal Article] The histone demethylase FBXL10 regulates the proliferation of spermatogonia and ensures long-term sustainable spermatogenesis in mice2016

    • Author(s)
      Ozawa M, Fukuda T, Nakamoto R, Honda H, Yoshida N
    • Journal Title

      Biology of Reproduction

      Volume: 94 Issue: 4 Pages: 1-11

    • DOI

      10.1095/biolreprod.115.135988

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K18386, KAKENHI-PROJECT-25860157, KAKENHI-PROJECT-16H06276
  • [Journal Article] Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex.2016

    • Author(s)
      Zhang X, Chen H, Wu X, Kodani A, Fan J, Doan R, Ozawa M, Ma J, Yoshida N, Reiter JF, Black DL, Kharchenko PV, Sharp PA, Walsh CA.
    • Journal Title

      Cell

      Volume: 166 Issue: 5 Pages: 1147-1162

    • DOI

      10.1016/j.cell.2016.07.025

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K18386, KAKENHI-PROJECT-16H06276
  • [Journal Article] Regulation of gene expression in the bovine blastocyst by colony stimulating factor 22016

    • Author(s)
      Ozawa M, Sakatani M, Dobbs K, Kannampuzha-Francis J, Hansen PJ.
    • Journal Title

      BMC Research Notes

      Volume: 9 Issue: 1 Pages: 250-250

    • DOI

      10.1186/s13104-016-2038-y

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K18386
  • [Journal Article] The histone demethylase Fbxl11/Kdm2a plays an essential role in embryonic development by repressing cell-cycle regulators2015

    • Author(s)
      Kawakami E, Tokunaga A, Ozawa M, Sakamoto R, Yoshida N.
    • Journal Title

      Mechanisms of Development

      Volume: 135 Pages: 31-42

    • DOI

      10.1016/j.mod.2014.10.001

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25860157, KAKENHI-PROJECT-15K06804
  • [Journal Article] Development of FGF2-dependent pluripotent stem cells showing naive state characteristics from murine preimplantation inner cell mass.2014

    • Author(s)
      Ozawa, M., Kawakami, E., Sakamoto, R., Shibasaki, T., Goto, A. and Yoshida, N.
    • Journal Title

      Stem Cell Research

      Volume: in press Issue: 1 Pages: 75-87

    • DOI

      10.1016/j.scr.2014.04.012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23870007, KAKENHI-PROJECT-25460431, KAKENHI-PROJECT-25860157
  • [Journal Article] Development of FGF2-dependent pluripotent stem cells showing naïve state characteristics from murine preimplantation inner cell mass2014

    • Author(s)
      Ozawa, M., Kawakami, E., Sakamoto, R., Shibasaki, T., Goto, A., and Yoshida, N.
    • Journal Title

      Stem Cell Research

      Volume: 13 Pages: 75-84

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23870007
  • [Patent] 超長鎖DNAの効率的なノックインによるヒト化マウス作製技術の開発2023

    • Inventor(s)
      小沢学、田口純平
    • Industrial Property Rights Holder
      小沢学、田口純平
    • Industrial Property Rights Type
      特許
    • Filing Date
      2023
    • Data Source
      KAKENHI-PROJECT-20H03162
  • [Patent] 超長鎖DNAの効率的なノックインによるヒト化マウス作製技術の開発2023

    • Inventor(s)
      小沢学、田口純平
    • Industrial Property Rights Holder
      小沢学、田口純平
    • Industrial Property Rights Type
      特許
    • Filing Date
      2023
    • Data Source
      KAKENHI-PROJECT-23K27084
  • [Presentation] 複数アリルの同時改変が可能な CRISPR/Cas9 リボ核蛋白質を用いた ES 細胞への効率的ノックイン法2023

    • Author(s)
      田口純平、山田泰広、伊川正人、小沢学
    • Organizer
      日本実験動物学会
    • Data Source
      KAKENHI-PROJECT-23K27084
  • [Presentation] Declining spermatogenic activities accompanied by the senescent feature of endothelial cells in male mice with age2023

    • Author(s)
      Manabu Ozawa, Hideto Mori, Tsutomu Endo, Masahito Ikawa
    • Organizer
      Society for the Study of Reproduction
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03162
  • [Presentation] Declining spermatogenic activities accompanied by the senescent feature of endothelial cells in male mice with age2023

    • Author(s)
      Manabu Ozawa, Hideto Mori, Tsutomu Endo, Masahito Ikawa
    • Organizer
      Society for the Study of Reproduction
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K27084
  • [Presentation] RNA 結合タンパク質 PTBP1 は精原細胞の増殖性を制御することで精子形成に寄与する2019

    • Author(s)
      小沢学、妹尾真奈美、山田泰広、伊川正人
    • Organizer
      東京大学生命科学シンポジウム
    • Data Source
      KAKENHI-PROJECT-17K07132
  • [Presentation] Polypyrimidine tract binding protein (Ptbp1) expression by Sertoli cells is essential for sperm production2019

    • Author(s)
      Ozawa M, Senoo M, Takijiri T, Yamamoto T, Yamada Y, Ikawa M
    • Organizer
      Society for the Study of Reproduction
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K07132
  • [Presentation] RNA結合タンパク質PTBP1は精原細胞の増殖性を制御することで精子形成に寄与する2019

    • Author(s)
      小沢 学,妹尾 真奈美,伊川 正人
    • Organizer
      第112回日本繁殖生物学会大会
    • Data Source
      KAKENHI-PROJECT-17K07132
  • [Presentation] セルトリ細胞で発現するRNA結合タンパク質Ptbp1は精子形成に不可欠である2018

    • Author(s)
      小沢学、吉田進昭、伊川正人
    • Organizer
      日本繁殖生物学会大会
    • Data Source
      KAKENHI-PROJECT-17K07132
  • [Presentation] Polypyrimidine tract binding protein (Ptbp1) expression by Sertoli cells is essential for sperm production2018

    • Author(s)
      Ozawa M, Ikawa M, Yoshida N.
    • Organizer
      Society for the Study of Reproduction
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K18386
  • [Presentation] Polypyrimidine tract binding protein (Ptbp1) expression by Sertoli cells is essential for sperm production2018

    • Author(s)
      Ozawa M, Ikawa M, Yoshida N.
    • Organizer
      Society for the Study of Reproduction
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K07132
  • [Presentation] Polypyrimidine tract binding protein (Ptbp1) expression by Sertoli cells is essential for sperm production2018

    • Author(s)
      Ozawa M, Ikawa M, Yoshida N
    • Organizer
      Society for the Study of Reproduction
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K07132
  • [Presentation] The histone demethylase KDM2A regulates differentiation of spermatogonia in mice.2017

    • Author(s)
      Ozawa M, Kawakami E, Tokunaga A, Sakamoto R, Yoshida N.
    • Organizer
      World Congress of Reproductive Biology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K07132
  • [Presentation] The histone demethylase KDM2A regulates differentiation of spermatogonia in mice.2017

    • Author(s)
      Ozawa M, Kawakami E, Tokunaga A, Sakamoto R, Yoshida N.
    • Organizer
      World Congress of Reproductive Biology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K18386
  • [Presentation] The histone demethylase FBXL10 regulates the proliferation of spermatogonia and ensures long-term sustainable spermatogenesis in mice2016

    • Author(s)
      Ozawa M, Fukuda T, Sakamoto R, Honda H, Yoshida N
    • Organizer
      49th Annual Meeting of the Society for the Study of Reproduction
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2016-07-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K18386
  • [Presentation] The histone demethylase FBXL10 regulates the proliferation of spermatogonia and ensures long-term sustainable spermatogenesis in mice2016

    • Author(s)
      Ozawa M, Fukuda T, Sakamoto R, Honda H, Yoshida N
    • Organizer
      49th Annual Meeting of the Society for the Study of Reproduction
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2016-07-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25860157
  • [Presentation] The histone demethylase FBXL10 regulates the proliferation of spermatogonia and ensures long-term sustainable spermatogenesis in mice2016

    • Author(s)
      Ozawa M, Fukuda T, Sakamoto R, Honda H, Yoshida N
    • Organizer
      Annual meeting of the Society for the Study of Reproduction
    • Place of Presentation
      San Diego, CA USA
    • Year and Date
      2016-07-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K18386
  • [Presentation] Histone demethylase Fbxl11 regulates balance between self-renew and differentiation of spermatogonia in mice2015

    • Author(s)
      Ozawa M, Kawakami E, Tokunaga A, Sakamoto R, Yoshida N
    • Organizer
      48th Annual Meeting of the Society for the Study of Reproduction
    • Place of Presentation
      San Juan, Puerto Rico, USA
    • Year and Date
      2015-06-18
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K18386
  • [Presentation] Histone demethylases Fbxl11 regulates balance between self-renew and differentiation of spermatogonia in mice2015

    • Author(s)
      Ozawa M, Kawakami E, Tokunaga A, Sakamoto R, Yoshida N
    • Organizer
      48th Annual Meeting of the Society for the Study of Reproduction
    • Place of Presentation
      San Juan, Puerto Rico, USA
    • Year and Date
      2015-06-18
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25860157
  • [Presentation] ヒストン脱メチル化酵素Kdm2aは精原細胞の自己複製と分化のバランスを調整する2015

    • Author(s)
      小沢学 川上絵里 徳永暁憲 坂本怜子 吉田進昭
    • Organizer
      第38回 日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド 兵庫県神戸市
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-25860157
  • [Presentation] ヒストン脱メチル化酵素Kdm2aは精原細胞の自己複製と分化のバランスを調整する2015

    • Author(s)
      小沢学 川上絵里 徳永暁憲 坂本怜子 吉田進昭
    • Organizer
      第38回 日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド 兵庫県神戸市
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-15K18386
  • [Presentation] Histone demethylases Fbxl10 and its homolog Fbxl11 regulate male germ cell development and sustainable spermatogenesis by different methods in mice2013

    • Author(s)
      Ozawa M, et al
    • Organizer
      Society for the Study of Reproduction
    • Place of Presentation
      Montreal, Canada
    • Data Source
      KAKENHI-PROJECT-23870007
  • [Presentation] ヒストン脱メチル化酵素Kdm2aによる精子形成の制御機序2013

    • Author(s)
      小沢学 川上絵里 徳永暁憲 坂本怜子 吉田進昭
    • Organizer
      日本繁殖生物学会
    • Place of Presentation
      東京農工大学
    • Data Source
      KAKENHI-PROJECT-23870007
  • [Presentation] Histone demethylases Fbxl10 and its homolog Fbxl11 regulate male germ cell development and sustainable spermatogenesis by different methods in mice2013

    • Author(s)
      Ozawa M, Kawakami E, Fukuda T, Sakamoto R, Yoshida N
    • Organizer
      Society for the Study of Reproduction
    • Place of Presentation
      Montreal, Canada
    • Data Source
      KAKENHI-PROJECT-25860157
  • [Presentation] Fbxl10は精原細胞の加齢を抑制することで持続的な精子形成を保証する2013

    • Author(s)
      小沢学、福田剛、坂本怜子、吉田進昭
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸国際会議場
    • Data Source
      KAKENHI-PROJECT-23870007
  • [Presentation] ヒストン脱メチル化酵素Kdm2aによる精子形成の制御機序2013

    • Author(s)
      小沢学 川上絵里 徳永暁憲 坂本怜子 吉田進昭
    • Organizer
      日本繁殖生物学会
    • Place of Presentation
      東京農工大学
    • Data Source
      KAKENHI-PROJECT-25860157
  • [Presentation] ヒストン脱メチル化酵素Kdm2aによる精子形成の制御機序2013

    • Author(s)
      小沢学, 他
    • Organizer
      日本繁殖生物学会
    • Place of Presentation
      府中
    • Data Source
      KAKENHI-PROJECT-23870007
  • [Presentation] ヒストンのエピジェネティック修飾に よる持続的精子形成の維持機序の探索2013

    • Author(s)
      小沢学
    • Organizer
      日本分子生物学会 ランチョンセミナー
    • Place of Presentation
      神戸国際会議場
    • Invited
    • Data Source
      KAKENHI-PROJECT-25860157
  • [Presentation] ヒストンのエピジェネティック修飾に よる持続的精子形成の維持機序の探索2013

    • Author(s)
      小沢学
    • Organizer
      日本分子生物学会 ランチョンセミナー
    • Place of Presentation
      神戸国際会議場
    • Invited
    • Data Source
      KAKENHI-PROJECT-23870007
  • [Presentation] Fbxl10は精原細胞の加齢を抑制することで持続的な精子形成を保証する2013

    • Author(s)
      小沢学, 他
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-23870007
  • [Presentation] Histone demethylases Fbxl10 and its homolog Fbxl11 regulate male germ cell development and sustainable spermatogenesis by different methods in mice.2013

    • Author(s)
      Ozawa M, Kawakami E, Fukuda T, Sakamoto R, Yoshida N
    • Organizer
      Society for the Study of Reproduction
    • Place of Presentation
      Montreal, Canada
    • Data Source
      KAKENHI-PROJECT-23870007
  • [Presentation] Establishment of novel embryonic stem cell line which grows under GF stimulation but has germline competency in mice2012

    • Author(s)
      小沢学, 他
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-23870007
  • [Presentation] ヒストン脱メチル化酵素Fbxl10による精子形成の制御機序2012

    • Author(s)
      小沢学, 他
    • Organizer
      日本繁殖生物学会
    • Place of Presentation
      つくば
    • Data Source
      KAKENHI-PROJECT-23870007
  • [Presentation] ウシ胚におけるFGFRの発現プロファイリングおよび着床期におけるFGF-FGFRを介したシグナルトランスダクションの役割2011

    • Author(s)
      小沢学
    • Organizer
      日本繁殖生物学会
    • Place of Presentation
      岩手県盛岡市
    • Year and Date
      2011-09-16
    • Data Source
      KAKENHI-PROJECT-23870007
  • [Presentation] ヒストン脱メチル化酵素Fbxl10はマウス精原細胞の加齢を抑制することで持続的な精子形成を調整する

    • Author(s)
      小沢学,福田剛,坂本怜子,吉田進昭
    • Organizer
      高遠分子細胞生物学シンポジウム
    • Place of Presentation
      長野県伊那市
    • Year and Date
      2014-08-28 – 2014-08-29
    • Data Source
      KAKENHI-PROJECT-25860157
  • 1.  伊川 正人 (20304066)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 2.  新岡 宏彦 (70552074)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  山口 貴世志 (50466843)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  山口 卓男 (80596601)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  FUJIHARA Yoshitaka
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  SAKAMOTO Takeharu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  江口 貴大
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  山内 祐
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 9.  山田 泰広
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 10.  柴田 博史
    # of Collaborated Projects: 0 results
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