Sasaki Izumi 佐々木泉

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SASAKI Izumi 佐々木泉

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Researcher Number	80611037
Other IDs	https://orcid.org/0000-0001-5080-8356
Affiliation (Current)	2025: 和歌山県立医科大学, 先端医学研究所, 講師
Affiliation (based on the past Project Information) *help	2019 – 2024: 和歌山県立医科大学, 先端医学研究所, 講師 2014 – 2016: 和歌山県立医科大学, 先端医学研究所, 助教 2013: 大阪大学, 免疫学フロンティア研究センター, 特任研究員(常勤)
Review Section/Research Field	Principal Investigator Experimental pathology / Basic Section 49030:Experimental pathology-related / Basic Section 49070:Immunology-related Except Principal Investigator Transformative Research Areas, Section (III)
Keywords	Principal Investigator コレラ毒素 / 小胞体ストレス応答 / インフラマソーム / 腹腔マクロファージ / 炎症性サイトカインIL-1β / PYRINインフラマソーム / 小胞体ストレスセンサーIRE1α / 腹腔常在マクロファージ / 小胞体ストレス / IRE1α … More / IL-1β / IL-1beta / Pyrinインフラマソーム / NLRP3インフラマソーム / 樹状細胞 … More Except Principal Investigator 細胞内輸送 / 免疫不全 / 獲得免疫 / 遺伝子改変マウス / タンパク質分解 / 自己炎症 / プロテアソーム Less

細胞内輸送関連分子により制御される炎症性サイトカイン産生誘導の新規分子機構の解明Principal Investigator
- Principal Investigator
  
  佐々木泉
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Wakayama Medical University
Clarification of self recognition mechanisms by intracellular protein fluctuation
- Principal Investigator
  
  改正恒康
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Wakayama Medical University
The role of unfolded protein responses in cholera toxin-induced immune adjuvant effectPrincipal Investigator
- Principal Investigator
  
  Sasaki Izumi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Wakayama Medical University
Elucidation of the novel molecular mechanisms of proinflammatory cytokine production regulated by metabolism-related moleculesPrincipal Investigator
- Principal Investigator
  
  Sasaki Izumi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Wakayama Medical University
Elucidation of molecular mechanism of cholera toxin-induced immune adjuvant effectPrincipal Investigator
- Principal Investigator
  
  SASAKI Izumi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Wakayama Medical University
  Osaka University

All 2024 2023 2022 2021 2020 2019 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Book

[Book] Adv Exp Med Biol. asu Kaisho, Autoinflammatory Diseases Due to Defects in Degradation or Transport of Intracellular Proteins.,2024
- Author(s)
  Izumi Sasaki, Takashi Kato, Nobuo Kanazawa, Tsuneyasu Kaisho
- Total Pages
  252
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-22K07006
[Book] Autoinflammatory diseases due to defects in degradation or transport of intracellular proteins, in Basic Immunology and Its Clinical Application2023
- Author(s)
  I. Sasaki, T. Kato, N. Kanazawa, T. Kaisho.
- Total Pages
  13
- Publisher
  Springer
- ISBN
  9789819997800
- Data Source
  KAKENHI-PLANNED-22H05187
[Journal Article] Mouse model of autoinflammatory disease with dysfunction of intracellular DNA sensor system2024
- Author(s)
  加藤喬、佐々木泉、改正恒康.
- Journal Title
  
  JSIAD Journal
  
  Volume: 3 Issue: 1 Pages: 2-7
- DOI
  10.34563/jsiadjournal.3.1_2
- ISSN
  2435-7693
- Year and Date
  2024-02-02
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K18222, KAKENHI-PROJECT-23K19487, KAKENHI-PLANNED-22H05187
[Journal Article] A stress sensor, IRE1α, is required for bacterial-exotoxin-induced interleukin-1β production in tissue-resident macrophages2024
- Author(s)
  I. Sasaki, Y. Fukuda-Ohta, C. Nakai, N. Wakaki-Nishiyama, C. Okamoto, D. Okuzaki, S. Morita, S. Kaji, Y. Furuta, H. Hemmi, T. Kato, A. Yamamoto, E. Tosuji, SI Saitoh, T. Tanaka, K. Hoshino, S. Fukuda, K. Miyake, E. Kuroda, KJ Ishii, T. Iwawaki, K. Furukawa, T. Kaisho.
- Journal Title
  
  Cell Reports
  
  Volume: 43 Issue: 4 Pages: 113981-113981
- DOI
  10.1016/j.celrep.2024.113981
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18222, KAKENHI-PROJECT-23K19487, KAKENHI-PROJECT-22K07006, KAKENHI-PROJECT-22K19424, KAKENHI-PLANNED-22H05184, KAKENHI-PLANNED-22H05187, KAKENHI-PROJECT-21H04800, KAKENHI-PROJECT-23K27421
[Journal Article] SpiB regulates the expression of B-cell-related genes and increases the longevity of memory B cells2023
- Author(s)
  S. Horiuchi, T. Koike, H. Takebuchi, K. Hoshino, I. Sasaki, Y. Fukuda-Ohta, T. Kaisho, D. Kitamura.
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 14 Pages: 1250719-1250719
- DOI
  10.3389/fimmu.2023.1250719
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18222, KAKENHI-PROJECT-22K07006, KAKENHI-PLANNED-22H05187
[Journal Article] Preparation and Inflammasome Activation of Murine Bone Marrow-Derived and Resident Peritoneal Macrophages2022
- Author(s)
  Sasaki I, Kaisho T.
- Journal Title
  
  Methods Mol Biol.
  
  Volume: 2427 Pages: 95-104
- DOI
  10.1007/978-1-0716-1971-1_9
- ISBN
  9781071619704, 9781071619711
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07006, KAKENHI-PLANNED-22H05187, KAKENHI-PROJECT-20H03505, KAKENHI-PROJECT-21K19384
[Journal Article] Conventional Type 1 Dendritic Cells in Intestinal Immune Homeostasis.2022
- Author(s)
  Sasaki I, Kato T, Hemmi H, Fukuda-Ohta Y, Wakaki-Nishiyama N, Yamamoto A, Kaisho T.
- Journal Title
  
  Front Immunol.
  
  Volume: 13 Pages: 857954-857954
- DOI
  10.3389/fimmu.2022.857954
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07006, KAKENHI-PLANNED-22H05187, KAKENHI-PROJECT-20H03505, KAKENHI-PROJECT-21J22615, KAKENHI-PROJECT-21K19384
[Journal Article] Augmentation of STING‐induced type I interferon production in COPA syndrome2021
- Author(s)
  Kato Takashi、Yamamoto Masaki、Honda Yoshitaka、Orimo Takashi、Sasaki Izumi、Murakami Kohei、Hemmi Hiroaki、Fukuda‐Ohta Yuri、Isono Kyoichi、Takayama Saki、Nakamura Hidenori、Otsuki Yoshiro、Miyamoto Toshiaki、Takita Junko、Yasumi Takahiro、Nishikomori Ryuta、Matsubayashi Tadashi、Izawa Kazushi、Kaisho Tsuneyasu
- Journal Title
  
  Arthritis & Rheumatology
  
  Volume: in press Issue: 11 Pages: 2105-2115
- DOI
  10.1002/art.41790
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H04813, KAKENHI-PROJECT-18K16096, KAKENHI-PROJECT-19K07628, KAKENHI-PROJECT-19K08299, KAKENHI-PROJECT-20K16289, KAKENHI-PROJECT-20H00528, KAKENHI-PROJECT-20H03505, KAKENHI-PROJECT-21J22615, KAKENHI-PROJECT-21K06956, KAKENHI-PROJECT-21K09216, KAKENHI-PROJECT-21K19384, KAKENHI-PROJECT-21K19405
[Journal Article] Heterozygous missense variant of the proteasome subunit β-type 9 causes neonatal-onset autoinflammation and immunodeficiency2021
- Author(s)
  Kanazawa N, Hemmi H, Kinjo N, Ohnishi H, Hamazaki J, M.H, K.A, M.T, H.S, K.N, K.S, H.Y, I.K, N.R, T.M, Y.Y, T.S, O.T, O.T, K.T, S.I, F.Y, W.N, I.Y, K.K, O.S, T.T, N.K, M.S, Y.K, Kaisho T
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 0-0
- DOI
  10.1038/s41467-021-27085-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07062, KAKENHI-PROJECT-19K07628, KAKENHI-PROJECT-19K08299, KAKENHI-PROJECT-20K16289, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05500, KAKENHI-PROJECT-18H04022, KAKENHI-PROJECT-19H03620, KAKENHI-PROJECT-20H03505, KAKENHI-PROJECT-20H03591, KAKENHI-PROJECT-21J22615, KAKENHI-PROJECT-19K08754, KAKENHI-PROJECT-19K08798, KAKENHI-PROJECT-19K09993, KAKENHI-PROJECT-20K08158, KAKENHI-PROJECT-20K08718, KAKENHI-PROJECT-21K06956, KAKENHI-PROJECT-21K07770, KAKENHI-PROJECT-21K07800, KAKENHI-PROJECT-21K19384, KAKENHI-PROJECT-20K17405
[Journal Article] The mechanism of action of Spi-B in the transcriptional activation of the interferon-α4 gene.2020
- Author(s)
  R. Miyazaki, H. Saiga, T. Kato, T. Bakoshi, R. Senba, A. Shintani, M. Suzuki, K. Takao, I. Sasaki, A. Iizuka, M. Sugiyama, N. Iwami, Y. Fukuda-Ohta, H. Hemmi, T. Tanaka, M. Miyake, T. Kaisho, K. Hoshino.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 30;525 Issue: 2 Pages: 477-482
- DOI
  10.1016/j.bbrc.2020.02.101
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16096, KAKENHI-PUBLICLY-19H04813, KAKENHI-PROJECT-17H04088, KAKENHI-PROJECT-19K07628, KAKENHI-PROJECT-18K07071
[Journal Article] Anticancer effects of chemokine-directed antigen delivery to a cross-presenting dendritic cell subset with immune checkpoint blockade2020
- Author(s)
  Mizumoto Y, Hemmi H, Katsuda M, Miyazawa M, Kitahata Y, Miyamoto A, Nakamori M, Ojima T, Matsuda K, Nakamura M, Hayata K, Fukuda-Ohta Y, Sugiyama M, Ohta T, Orimo T, Okura S, Sasaki I, Tamada K, Yamaue H, Kaisho T.
- Journal Title
  
  British Journal of Cancer
  
  Volume: 122 Issue: 8 Pages: 1185-1193
- DOI
  10.1038/s41416-020-0757-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07071, KAKENHI-PROJECT-19K09183, KAKENHI-PROJECT-18K16096, KAKENHI-PUBLICLY-19H04813, KAKENHI-PROJECT-17H04088, KAKENHI-PROJECT-17K10603, KAKENHI-PROJECT-17K10604, KAKENHI-PROJECT-17K10711, KAKENHI-PROJECT-19K07628, KAKENHI-PROJECT-20K09063, KAKENHI-PROJECT-19K18101, KAKENHI-PROJECT-20K16289, KAKENHI-PROJECT-17H01580, KAKENHI-PROJECT-19K23848
[Journal Article] Cholera toxin B induces interleukin-1β production from resident peritoneal macrophages through the pyrin inflammasome as well as the NLRP3 inflammasome2019
- Author(s)
  Orimo T, Sasaki I, Hemmi H, Ozasa T, Fukuda-Ohta Y, Ohta T, Morinaka M, Kitauchi M, Yamaguchi T, Sato Y, Tanaka T, Hoshino K, Katayama KI, Fukuda S, Miyake K, Yamamoto M, Satoh T, Furukawa K, Kuroda E, Ishii KJ, Takeda K, Kaisho T
- Journal Title
  
  International Immunology
  
  Volume: 印刷中 Issue: 10 Pages: 657-668
- DOI
  10.1093/intimm/dxz004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07071, KAKENHI-PUBLICLY-17H05799, KAKENHI-PROJECT-17H04088, KAKENHI-PROJECT-17K19568, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19K07628, KAKENHI-PROJECT-19K22518, KAKENHI-PROJECT-18K16096, KAKENHI-PROJECT-19K23848, KAKENHI-PUBLICLY-19H04813, KAKENHI-PROJECT-17K19616, KAKENHI-PROJECT-18H02628
[Journal Article] Identification of a novel CCDC22 mutation in a patient with severe Epstein?Barr virus-associated hemophagocytic lymphohistiocytosis and aggressive natural killer cell leukemia2019
- Author(s)
  Yamashita Y, Nishikawa A, Iwahashi Y, Fujimoto M, Sasaki I, Mishima H, Kinoshita A, Hemmi H, Kanazawa N, Ohshima K, Imadome KI, Murata SI、Yoshiura KI, Kaisho T, Sonoki T, Tamura S
- Journal Title
  
  International Journal of Hematology
  
  Volume: 印刷中 Issue: 6 Pages: 744-750
- DOI
  10.1007/s12185-019-02595-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07071, KAKENHI-PROJECT-18K07850, KAKENHI-PUBLICLY-17H05799, KAKENHI-PROJECT-17H04088, KAKENHI-PROJECT-17K19568, KAKENHI-PROJECT-19K07628, KAKENHI-PROJECT-19K08821, KAKENHI-PROJECT-19K22913, KAKENHI-PROJECT-18KK0245, KAKENHI-PUBLICLY-19H04813, KAKENHI-PROJECT-16KT0112
[Journal Article] Programmed cell death ligand 1 disruption by clustered regularly interspaced short palindromic repeats/Cas9‐genome editing promotes antitumor immunity and suppresses ovarian cancer progression2019
- Author(s)
  Yahata T, Mizoguchi M, Kimura A, Orimo T, Toujima S, Kuninaka Y, Nosaka M, Ishida Y, Sasaki I, Fukuda‐Ohta Y, Hemmi H, Iwahashi N, Noguchi T, Kaisho T, Kondo T, Ino K
- Journal Title
  
  Cancer Science
  
  Volume: 110 Issue: 4 Pages: 1279-1292
- DOI
  10.1111/cas.13958
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07071, KAKENHI-PROJECT-18K10134, KAKENHI-PUBLICLY-17H05799, KAKENHI-PROJECT-17H04088, KAKENHI-PROJECT-17K19568, KAKENHI-PROJECT-19K07628, KAKENHI-PROJECT-18K16096, KAKENHI-PUBLICLY-19H04813, KAKENHI-PROJECT-17K11293, KAKENHI-PROJECT-17K16863
[Journal Article] Crucial roles of XCR1-expressing dendritic cells and the XCR1-XCL1 chemokine axis in intestinal immune homeostasis.2016
- Author(s)
  Ohta T, Sugiyama M, Hemmi H, Yamazaki C, Okura S, Sasaki I, Fukuda Y, Orimo T, Ishii KJ, Hoshino K, Ginhoux F, Kaisho T.
- Journal Title
  
  Scientific Reports
  
  Volume: 162 Issue: 1 Pages: 23505-23505
- DOI
  10.1038/srep23505
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08431, KAKENHI-PROJECT-26461465, KAKENHI-PROJECT-15K19077, KAKENHI-PROJECT-14J04735, KAKENHI-PROJECT-26293106, KAKENHI-PROJECT-16K19585
[Journal Article] Transcription factor IRF8 plays a critical role in the development of murine basophils and mast cells.2015
- Author(s)
  H. Sasaki, D. Kurotaki, N. Osato, H. Sato, I. Sasaki, S. Koizumi, H. Wang, C. Kaneda, A. Nishiyama, T. Kaisho, H. Aburatani, H. C. Morse III, K. Ozato, T. Tamura.
- Journal Title
  
  Blood
  
  Volume: 125(2) Issue: 2 Pages: 358-369
- DOI
  10.1182/blood-2014-02-557983
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-21117003, KAKENHI-PLANNED-24118002, KAKENHI-PROJECT-24390246, KAKENHI-PROJECT-24790322, KAKENHI-PROJECT-25870401, KAKENHI-PROJECT-26293106, KAKENHI-PROJECT-26460373, KAKENHI-PROJECT-15K19077
[Journal Article] Transcriptional Control of dendritic cell differentiation.2014
- Author(s)
  I. Sasaki, T. Kaisho
- Journal Title
  
  Curr. Top. Microbiol. Immunol.
  
  Volume: 381 Pages: 257-278
- DOI
  10.1007/82_2014_378
- ISBN
  9783319073941, 9783319073958
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-21117003, KAKENHI-PROJECT-25870401, KAKENHI-PROJECT-26293106
[Journal Article] Limitation of immune tolerance-inducing thymic epithelial cell development by Spi-B-mediated negative feedback regulation.2014
- Author(s)
  Akiyama, N., Shinzawa, M., Miyauchi, M., Yanai, H., Tateishi, R., Shimo, Y., Ohshima, D., Matsuo, M., Sasaki. I., Hoshino, K., Wu, G., Yagi, S., Inoue, J., Kaisho, T. and Akiyama, T.
- Journal Title
  
  J. Exp. Med.
  
  Volume: 211 Issue: 12 Pages: 2425-2438
- DOI
  10.1084/jem.20141207
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-22117001, KAKENHI-PROJECT-24390071, KAKENHI-PROJECT-25870401, KAKENHI-PROJECT-26461465, KAKENHI-PROJECT-26670234
[Journal Article] Critical roles of a dendritic cell subset expressing a chemokine receptor, XCR12013
- Author(s)
  C. Yamazaki, M. Sugiyama, T. Ohta, H. Hemmi, E. Hamada, I. Sasaki, Y. Fukuda, T. Yano, M. Nobuoka, T. Hirashima, A. Iizuka, K. Sato, T. Tanaka, K. Hoshino, T. Kaisho
- Journal Title
  
  J. Immunol
  
  Volume: 190 Issue: 12 Pages: 6071-6082
- DOI
  10.4049/jimmunol.1202798
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390124, KAKENHI-PROJECT-23590577, KAKENHI-PROJECT-23659245, KAKENHI-PROJECT-24590460, KAKENHI-PROJECT-25293117, KAKENHI-PROJECT-25870401
[Presentation] A stress sensor IRE1α is required for bacterial exotoxin-induced inflammasome activation in tissueresident macrophages.2024
- Author(s)
  I. Sasaki, Y. Fukuda-Ohta, S. Morita, D. Okuzaki, T. Kato, K. Furukawa, T. Kaisho.
- Organizer
  第52回本免疫学会総会・学術集会
- Data Source
  KAKENHI-PLANNED-22H05187
[Presentation] 小胞体ストレスセンサーIRE1aは腹腔常在マクロファージにおける炎症性サイトカインIL-1bの産生誘導に必要である2024
- Author(s)
  佐々木泉
- Organizer
  第32回東京免疫フォーラム
- Data Source
  KAKENHI-PROJECT-22K07006
[Presentation] Generation and characterization of thePsmb8 G201V mutation knock-in mice as a model for Nakajo-Nishimura syndrome2024
- Author(s)
  T. Hara, T. Kato, J. Hamazaki, A. Kinoshita, Y. Inaba, I. Sasaki, K. -I. Yoshiura, M. Jinnin, T. Kaisho, N. Kanazawa.
- Organizer
  APSID-JSIAD 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05187
[Presentation] A stress sensor IRE1a is required for bacterial exotoxin-induced inflammasome activation in tissue resident macrophages2024
- Author(s)
  Izumi Sasaki, Yuri Fukuda-Ohta, Shuhei Morita, Daisuke Okuzaki, Takashi Kato, Koichi Furukawa, Tsuneyasu Kaisho
- Organizer
  The 52nd Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-22K07006
[Presentation] A stress sensor IRE1a is involved in bacterial exotoxin-induced inflammasome activation in tissue resident macrophages2023
- Author(s)
  Izumi Sasaki, Shiori Kaji, Naoko Wakaki-Nishiyama, Daisuke Okuzaki, Shuhei Morita, Takashi Kato, Asumi Yamamoto, Koichi Furukawa, Tsuneyasu Kaisho
- Organizer
  JSICR/MMCB 2023 Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07006
[Presentation] Spi-Bは圧負荷に対する心臓の代償応答過程においてマクロファージサブセットの構成を制御して抗炎症性に機能する2023
- Author(s)
  近藤稔和、木村章彦、佐々木泉、石田裕子、野坂みずほ、樽谷玲、國中由美、加藤喬、改正恒康
- Organizer
  第44回日本炎症・再生医学会
- Data Source
  KAKENHI-PLANNED-22H05187
[Presentation] A stress sensor IRE1α is required for bacterial exotoxin-induced inflammasome activation in tissue resident macrophages.2023
- Author(s)
  I. Sasaki, N. W-. Nishiyama, D. Okuzaki, S. Morita, T.Kato, A.Yamamoto, K. Furukawa, T.Kaisho.
- Organizer
  第30回日本免疫毒性学会学術年会
- Data Source
  KAKENHI-PLANNED-22H05187
[Presentation] Impairment of plasma cell generation in mice carrying a proteasome subunit β1i missense mutation derived from patients with autoinflammation and adaptive immune deficiency.2023
- Author(s)
  T. Kato, A. Yamamoto, I. Sasaki, N. Wakaki-Nishiyama, H. Hemmi, N. Kanazawa, W. Ise, T. Kaisho.
- Organizer
  Japan and Australia Meeting on Cell Death 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05187
[Presentation] A stress sensor IRE1a is required for bacterial exotoxin-induced inflammasome activation in tissue resident macrophages2023
- Author(s)
  Izumi Sasaki, Naoko Wakaki-Nishiyama, Daisuke Okuzaki, Shuhei Morita, Takashi Kato, Asumi Yamamoto, Ko-ichi Furukawa, Tsuneyasu Kaisho
- Organizer
  第30回日本免疫毒性学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07006
[Presentation] Generation and characterization of thePsmb8 G201V mutation knock-in mice as a model for Nakajo-Nishimura syndrome2023
- Author(s)
  T. Hara, T. Kato, J. Hamazaki, A. Kinoshita, Y. Inaba, I. Sasaki, K. -I. Yoshiura, M. Jinnin, T. Kaisho, N. Kanazawa.
- Organizer
  ISID 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05187
[Presentation] 生体内マクロファージにおけるパイリンインフラマソーム活性化機構の解明.2023
- Author(s)
  加治汐梨、佐々木泉、古田有希、加藤喬、西山奈央子、山本明日美、北野雅之、改正恒康.
- Organizer
  第30回日本免疫毒性学会学術年会
- Data Source
  KAKENHI-PLANNED-22H05187
[Presentation] Dendritic and T cell abnormalities in an autoinflammatory disease with interstitial lung disease and type 1 interferonopathy caused by a disability of retrongrade protein trafficking.2022
- Author(s)
  T. Kato, I.Sasaki, H. Hemmi, Y. Honda. K. Izawa, R. Nishikomori, T. Kaisho.
- Organizer
  第51回日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PLANNED-22H05187
[Presentation] Lig4遺伝子の低形成性変異を有したマウスは異常Th1細胞による炎症性腸疾患を発症する2022
- Author(s)
  田村志宜、山下友佑、小浴秀樹、加藤喬、岩淵貞弘、佐々木泉、橋本真一、改正恒康
- Organizer
  第6回日本免疫不全・自己炎症学会総会
- Data Source
  KAKENHI-PLANNED-22H05187
[Presentation] Activation of type I Interferon signaling in dendritic cells and T cells of the mouse model of COPA syndrome2022
- Author(s)
  Takashi Kato, Ryota Yamasaki, Naoko Wakaki-Nishiyama, Izumi Sasaki, Shiori Kaji, Kohei Murakami, Hiroaki Hemmi, Yoshitaka Honda, Kazushi Izawa, Yoshiro Otsuki, Tadashi Matsubayashi, Ryuta Nishikomori, Tsuneyasu Kaisho
- Organizer
  第29回日本免疫毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-22K07006
[Presentation] 遺伝子改変マウスを用いた組織常在マクロファージの免疫学的解析2022
- Author(s)
  加治汐梨，佐々木泉，加藤喬，西山奈央子，山本明日美, 脇村一輝，北野雅之，改正恒康
- Organizer
  第29回日本免疫毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-22K07006
[Presentation] Hypomorphic mutation of Lig4 gene in mice predisposes to intestinal inflammation driven by Th1 cells2022
- Author(s)
  Y. Yamashita, T. Kato, H. Kosako, S. Iwabuchi, K. Tanaka, K. Nakashima, I. Sasaki, S. Hashimoto, K. Ohshima, T. Kaisho, T. Sonoki, S. Tamura.
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PLANNED-22H05187
[Presentation] 遺伝子改変マウスを用いた組織常在マクロファージの免疫学的解析2022
- Author(s)
  加治汐梨、佐々木泉、加藤喬、西山奈央子、山本明日美、脇村一輝、北野雅之、改正恒康
- Organizer
  第29回日本免疫毒性学会学術年会
- Data Source
  KAKENHI-PLANNED-22H05187
[Presentation] Activation of type 1 interferon signaling in dendritic cells and T cells of the mouse model of COPA syndrome.2022
- Author(s)
  T.Kato, R.Yamasaki, N.W-Nishiyama. I.Sasaki, S.Kaji, K.Murakami, H.Hemmi, Y.Honda, K.Izawa, Y.Otsuki, T.Matsubayashi, R.Nishikomori, T.Kaisho.
- Organizer
  第29回日本免疫毒性学会学術年会
- Data Source
  KAKENHI-PLANNED-22H05187
[Presentation] An endoplasmic reticulum stress sensor IRE1a is involved in cholera toxin-induced inflammasome activation in tissue-resident macrophages2022
- Author(s)
  Izumi Sasaki, Naoko Wakaki-Nishiyama, Shuhei Morita, Shiori Kaji, Daisuke Okuzaki, Asumi Yamamoto, Takashi Kato, Koichi Furukawa, Tsuneyasu Kaisho
- Organizer
  JSICR MMCB2022 Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07006
[Presentation] An endoplasmic reticulum stress sensor IRE1a is involved in cholera toxin-induced interleukin-1b production from tissue resident macrophages2021
- Author(s)
  Izumi Sasaki, Yuri Fukuda-Ohta, Naoko Wakaki-Nishiyama, Chihiro Nakai, Shuhei Morita, Daisuke Okuzaki, Mika Kaku, Kanta Sawase, Takashi Kato, Takashi Orimo, Ko-ichi Furukawa, Tsuneyasu Kaisho
- Organizer
  第28回日本免疫毒性学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07628
[Presentation] The role of IRE1α in cholera toxin B-induced interleukine-1β production from resident peritoneal macrophages2021
- Author(s)
  Izumi Sasaki, Chihiro Nakai, Shuhei Morita, Daisuke Okuzaki, Yuri Fukuda-Ohta, Takashi Orimo, Hiroaki Hemmi, Koichi Furukawa, Tsuneyasu Kaisho
- Organizer
  MMCB2020+1 The 27th International Symposium on Molecular Cell Biology of Macrophages
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07628
[Presentation] An endoplasmic reticulum stress sensor IRE1a is involved in cholera toxin-induced interleukin-1b production from resident peritoneal macrophages2021
- Author(s)
  Izumi Sasaki, Yuri Fukuda-Ohta, Shuhei Morita, Daisuke Okuzaki, Takashi Kato, Takashi Orimo, Koichi Furukawa, Tsuneyasu Kaisho
- Organizer
  The 50th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-19K07628
[Presentation] コレラ毒素による免疫アジュバント活性における小胞体ストレスセンサーIRE1αの機能的意義2021
- Author(s)
  佐々木泉, 中井千尋, 大田有里, 西山奈央子, 森田修平, 奥崎大介, 三並桃佳, 林茉里, 張江伊水, 田中日向子, 加藤喬, 折茂貴是, 古川鋼一, 改正恒康
- Organizer
  第25回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-19K07628
[Presentation] Critical roles of IRE1a in cholera toxin-induced interleukin-1b production from resident peritoneal macrophages2021
- Author(s)
  Izumi Sasaki, Yuri Fukuda-Ohta, Naoko Wakaki-Nishiyama, Chihiro Nakai, Shuhei Morita, Daisuke Okuzaki, Mika Kaku, Kanta Sawase, Asumi Yamamoto, Takashi Kato, Takashi Orimo, Ko-ichi Furukawa, Tsuneyasu Kaisho
- Organizer
  16th Meeting of the International Endotoxin and Innate Immunity Society (IEIIS 2021)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07628
[Presentation] コレラ毒素Bサブユニットによる免疫アジュバント活性における小胞体ストレスセンサーIRE1aの機能的意義2021
- Author(s)
  佐々木泉, 改正恒康
- Organizer
  第34回日本バイオセラピィ学会学術集会総会
- Data Source
  KAKENHI-PROJECT-19K07628
[Presentation] The roles of unfold protein responses in cholera toxin B-induced interleukine-1β production.2020
- Author(s)
  Sasaki I, Orimo T, Harie I, Takisawa Y, Furukawa K, Kaisho T.
- Organizer
  第27回日本免疫毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-19K07628
[Presentation] 自然免疫応答における小胞体ストレスセンサーIRE1αの機能的意義2020
- Author(s)
  三並桃佳、石田エヴァ如月、加藤喬、折茂貴是、大田（福田）有里、西山奈央子、中井千尋、佐々木泉、改正恒康
- Organizer
  第88回和歌山医学会総会
- Data Source
  KAKENHI-PROJECT-19K07628
[Presentation] 遺伝性炎症性疾患COPA症候群の分子基盤の解明2020
- Author(s)
  田中日向子、林茉里、加藤喬、折茂貴是、大田（福田）有里、西山奈央子、中井千尋、佐々木泉、改正恒康
- Organizer
  第88回和歌山医学会総会
- Data Source
  KAKENHI-PROJECT-19K07628
[Presentation] 遺伝性炎症性疾患COPA症候群のモデルマウスの樹立とその解析2020
- Author(s)
  張江伊水、滝沢優子、加藤喬、折茂貴是、大田（福田）有里、西山奈央子、中井千尋、佐々木泉、改正恒康
- Organizer
  第88回和歌山医学会総会
- Data Source
  KAKENHI-PROJECT-19K07628
[Presentation] コレラ毒素Bサブユニットによる炎症性サイトカインIL-1β産生誘導機構2019
- Author(s)
  佐々木泉、折茂貴是、邊見弘明、土屋慧馬、井上正一、熊谷直光、古川鋼一、改正恒康
- Organizer
  第26回日本免疫毒性学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07628
[Presentation] Analysis of mice carrying a novel and missense mutation of proteasome subunit gene identified in a patient with autoinflammation and immune deficiency.2019
- Author(s)
  Hemmi H, Orimo T, Nishiyama N, Kato T, Ozasa T, Sasaki I, Kinjo N, Kanazawa N, Kaisho T.
- Organizer
  第26回マクロファージ分子細胞生物学国際シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07628
[Presentation] コレラ毒素Bサブユニットは細胞内病原体センサーNLRP3とPyrinを介して炎症性サイトカインIL-1βの産生を誘導する2019
- Author(s)
  佐々木泉、折茂貴是、邊見弘明、古川鋼一、改正恒康
- Organizer
  第29回日本樹状細胞研究会
- Data Source
  KAKENHI-PROJECT-19K07628
[Presentation] Roles of endoplasmic reticulum stress in cholera toxin B-induced interleukine-1β production from resident peritoneal macrophages.2019
- Author(s)
  Sasaki I, Morita S, Okuzaki D, Orimo T, Hemmi H, Furukawa K, Kaisho T.
- Organizer
  第48回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07628
[Presentation] Cholera toxin B can induce interleukine-1β production in peritoneal macrophages through the pyrin inflammasome as well as the NLRP3 inflammasome.2019
- Author(s)
  Sasaki I, Orimo T, Hemmi H, Furukawa K, Kaisho T.
- Organizer
  The 18th Awaji International Forum on Infection and Immunity
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07628
[Presentation] Cholera toxin B can induce interleukine-1β production in peritoneal macrophages through the pyrin inflammasome as well as the NLRP3 inflammasome.2019
- Author(s)
  Sasaki I, Orimo T, Hemmi H, Furukawa K, Kaisho T.
- Organizer
  第26回マクロファージ分子細胞生物学国際シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07628
[Presentation] Defective dendritic cell and monocyte development in proteasome subunit mutant mice.2019
- Author(s)
  23.Hemmi H, Orimo T, Sasaki I, Kato T, Fukuda-Ohta Y, Kinjo N, Hamada S, Kinoshita A, Yoshiura KI, Ohnishi H, Kanazawa N, Kaisho T.
- Organizer
  第48回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07628
[Presentation] コレラ毒素Bサブユニットとリポ多糖による相乗的なIL-1β産生誘導機構2019
- Author(s)
  佐々木泉
- Organizer
  第28回内毒素・LPS研究会
- Data Source
  KAKENHI-PROJECT-19K07628
[Presentation] ヒト疾患由来プロテアソームサブユニット突然変異導入マウスにおける樹状細胞分化障害.2019
- Author(s)
  邊見弘明、小笹俊哉、加藤喬、折茂貴是、佐々木泉、大田（福田）有里、金澤伸雄、改正恒康.
- Organizer
  第29回日本樹状細胞研究会
- Data Source
  KAKENHI-PROJECT-19K07628
[Presentation] Spi-Bは圧負荷による心不全の病態形成において炎症と繊維化を抑制して保護的に機能する2017
- Author(s)
  木村章彦、石田裕子、野坂みずほ、佐々木泉、山本寛貴、國中由美、加藤喬、福田有里、改正恒康、近藤稔和
- Organizer
  第38回日本炎症・再生医学会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2017-07-18
- Data Source
  KAKENHI-PROJECT-15K19077
[Presentation] Metabolic basis for cholera toxin-induced IL-1beta production in synergy with lipopolysaccharides2016
- Author(s)
  SASAKI Izumi, FUKUDA Shinji, ORIMO Takashi, HEMMI Hiroaki, FUKUDA Yuri, OHTA Tomokazu & KAISHO Tsuneyasu
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター、ラグナガーデンホテル
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-15K19077
[Presentation] Crosstalk between XCR1-expressing dendritic cells and intestinal T cells keeps intestinal homeostasis through the XCR1-XCL1 chemokine axis2016
- Author(s)
  OHTA Tomokazu, HEMMI Hiroaki, FUKUDA Yuri, SASAKI Izumi, ORIMO Takashi & KAISHO Tsuneyasu
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター、ラグナガーデンホテル
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-15K19077
[Presentation] Role of the polyamine pathway in Cholera toxin-induced production of proinflammatory cytokines2015
- Author(s)
  ORIMO Takashi, SASAKI Izumi, FUKUDA Shinji, HEMMI Hiroaki, FUKUDA Yuri, KAISHO Tsuneyasu
- Organizer
  日本免疫学会総会・学術集会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K19077
[Presentation] 腸管免疫制御機構におけるXCR1陽性樹状細胞の役割2014
- Author(s)
  大田友和、邊見弘明、杉山正仲、佐々木泉、改正恒康
- Organizer
  第24回日本樹状細胞研究会
- Place of Presentation
  山形
- Year and Date
  2014-06-20
- Data Source
  KAKENHI-PROJECT-25870401
[Presentation] The transcription factor IRF8 is required for basophil development2013
- Author(s)
  SASAKI Haruka, KUROTAKI Daisuke, OSATO Naoki, SASAKI Izumi, KANEDA Chika, NISHIYAMA Akira, KAISHO Tsuneyasu, MORSE Herbert C. III, OZATO Keiko, TAMURA Tomohiko
- Organizer
  第42回日本免疫学会総会
- Place of Presentation
  幕張メッセ
- Data Source
  KAKENHI-PROJECT-25870401
[Presentation] In vivo roles of XC chemokine receptor 1-expressing dendritic cells.2013
- Author(s)
  Ohta T, Hemmi H, Yamazaki C, Sugiyama M, Sasaki I, Hoshino K, Kaisho T
- Organizer
  15th International Congress of Immunology.
- Place of Presentation
  MiCo - Milano Congressi
- Data Source
  KAKENHI-PROJECT-25870401
[Presentation] Function of XCR1-expressing dendritic cells in oral tolerance2013
- Author(s)
  HEMMI Hiroaki, SUGIYAMA Masanaka, OHTA Tomokazu, SASAKI Izumi, YAMAZAKI Chihiro, TANAKA Takashi, HOSHINO Katsuaki, KAISHO Tsuneyasu
- Organizer
  第42回日本免疫学会総会
- Place of Presentation
  幕張メッセ
- Data Source
  KAKENHI-PROJECT-25870401
[Presentation] Anovel mechanism to generate the intestinal intraepithelial T lymphocytes by XCR1-expressing dendritic cells2013
- Author(s)
  OHTA Tomokazu, HEMMI Hiroaki, YAMAZAKI Chihiro, SUGIYAMA Masanaka, SASAKi Izumi, HOSHINO Katsuaki, KAISHO Tsuneyasu
- Organizer
  第42回日本免疫学会総会
- Place of Presentation
  幕張メッセ
- Data Source
  KAKENHI-PROJECT-25870401
[Presentation] 形質細胞様樹状細胞の機能と分化制御におけるEtsファミリー転写因子Spi-Bの役割2013
- Author(s)
  佐々木　泉, 星野　克明, 辺見弘明, 改正恒康
- Organizer
  第23回日本樹状細胞研究会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-25870401
[Presentation] XCL1 and XCR1 are involved in intestinal immune homeostasis by dendritic cells
- Author(s)
  Ohta,T., Okura,S., Hemmi,H., Sugiyama,M., Sasaki,I., Yamazaki,C., Hoshino,K., Kaisho,T.
- Organizer
  第43回日本免疫学会学術集会
- Place of Presentation
  京都
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-25870401
[Presentation] Roles of Arginase I in Cholera toxin-induced production of proinflammatory cytokines
- Author(s)
  Sasaki,I., Fukuda,S., Orimo,T., Hemmi,H., Kaisho,T.
- Organizer
  第43回日本免疫学会学術集会
- Place of Presentation
  京都
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-25870401

1. 改正恒康 (60224325)

# of Collaborated Projects: 1 results

# of Collaborated Products: 19 results
2. FUKUDA Yuri

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 邊見弘明

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
4. 濱崎純

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 井上純一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sasaki Izumi 佐々木 泉

SASAKI Izumi 佐々木 泉

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細胞内輸送関連分子により制御される炎症性サイトカイン産生誘導の新規分子機構の解明Principal Investigator

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Clarification of self recognition mechanisms by intracellular protein fluctuation

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The role of unfolded protein responses in cholera toxin-induced immune adjuvant effectPrincipal Investigator

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Elucidation of the novel molecular mechanisms of proinflammatory cytokine production regulated by metabolism-related moleculesPrincipal Investigator

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Elucidation of molecular mechanism of cholera toxin-induced immune adjuvant effectPrincipal Investigator

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[Book] Adv Exp Med Biol. asu Kaisho, Autoinflammatory Diseases Due to Defects in Degradation or Transport of Intracellular Proteins.,2024

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[Book] Autoinflammatory diseases due to defects in degradation or transport of intracellular proteins, in Basic Immunology and Its Clinical Application2023

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[Journal Article] Mouse model of autoinflammatory disease with dysfunction of intracellular DNA sensor system2024

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[Journal Article] A stress sensor, IRE1α, is required for bacterial-exotoxin-induced interleukin-1β production in tissue-resident macrophages2024

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[Journal Article] SpiB regulates the expression of B-cell-related genes and increases the longevity of memory B cells2023

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[Journal Article] Preparation and Inflammasome Activation of Murine Bone Marrow-Derived and Resident Peritoneal Macrophages2022

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[Journal Article] Conventional Type 1 Dendritic Cells in Intestinal Immune Homeostasis.2022

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[Journal Article] Augmentation of STING‐induced type I interferon production in COPA syndrome2021

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Sasaki Izumi 佐々木泉

SASAKI Izumi 佐々木泉