TSUGE MITSURU 津下充

… Alternative Names

TSUGE Mitsuru 津下充

津下充ツゲミツル

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Researcher Number	80625004
Other IDs	https://orcid.org/0000-0001-9010-4708
Affiliation (Current)	2026: 岡山大学, 医歯薬学域, 教授
Affiliation (based on the past Project Information) *help	2023 – 2025: 岡山大学, 医歯薬学域, 准教授 2021 – 2022: 岡山大学, 医歯薬学域, 講師 2019 – 2020: 岡山大学, 医歯薬学総合研究科, 講師 2014: 松山赤十字病院, 小児科 2012: 岡山大学, 大学病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Infectious disease medicine
Keywords	Principal Investigator マクロファージ / 血管透過性 / 自然免疫 / インフルエンザ脳症 / 脳血管内皮細胞 / IL-6 / インターロイキン１受容体 / 血液脳関門 / トール様受容体 / IL-1受容体 … More / 末梢血単核球 / 血管内皮細胞 / COX-2 / ストレスファイバー / VEカドヘリン / HMGB-1 / 炎症性サイトカイン / 腫瘍壊死因子-α / タイトジャンクション / サイトカイン / 脳浮腫 / カイニン酸 / アセトアミノフェン / テオフィリン / ジクロフェナクナトリウム / 痙攣重積型インフルエンザ脳症 … More Except Principal Investigator サイトカイン / 好酸球増多症 / 早産児晩期循環不全 / 血管内皮障害 / 後遺症 / COVID-19 / 生体マーカー / ワクチン / 病態生理 / 小児 / 感染症 / 後遺障害 / 川崎病 / アミノ酸代謝 / 一酸化窒素 / 酸化ストレス / 合併症 / 予防接種 / ウイルス感染症 / 新型コロナウイルス / H1N1pdm / 喘息 / ARDS / AH7N9 / 脳症 / H5N1 / チオレドキシン / HMGB-1 / 肺炎 / インフルエンザ Less

早産児晩期循環不全の新しい予防・治療戦略に向けた病態解明と予測マーカーの開発
- Principal Investigator
  
  鷲尾洋介
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Okayama University
Elucidation of pathogenesis and preventive measures for complications in pediatric COVID-19
- Principal Investigator
  
  Tsukahara Hirokazu
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Okayama University
Development of novel treatments for influenza-associated encephalopathy by regulating IL-1 receptor and Toll-like receptor signalingPrincipal Investigator
- Principal Investigator
  
  Tsuge Mitsuru
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Okayama University
Search for new treatments for influenza associated encephalopathy targeting innate immune mediatorsPrincipal Investigator
- Principal Investigator
  
  TSUGE MITSURU
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Okayama University
Study of the therapeutic agent for the treatment of highly pathogenic influenza
- Principal Investigator
  
  MORISHIMA Tsuneo
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Infectious disease medicine
- Research Institution
  Okayama University
痙攣重積型インフルエンザ脳症の病態解析と新規治療薬の検索Principal Investigator
- Principal Investigator
  
  津下充
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Okayama University

All 2025 2024 2023 2022 2021 2020 2019 2014 2013

All Journal Article Presentation Book

[Book] Influenza: Advances in Diagnosis and Management2020
- Author(s)
  Tsuge M, Yashiro M, Ohno N, Tsukahara H, Fujita J
- Total Pages
  229
- Publisher
  Springer Nature
- Data Source
  KAKENHI-PROJECT-19K08278
[Journal Article] A randomized controlled trial of conventional GVHD prophylaxis with or without teprenone for the prevention of severe acute GVHD2025
- Author(s)
  Kitamura Wataru、Fujii Keiko、Tsuge Mitsuru、Mitsuhashi Toshiharu、Kobayashi Hiroki、Kamoi Chihiro、Yamamoto Akira、Kondo Takumi、Seike Keisuke、Fujiwara Hideaki、Asada Noboru、Ennishi Daisuke、Matsuoka Ken-ichi、Fujii Nobuharu、Maeda Yoshinobu
- Journal Title
  
  Annals of Hematology
  
  Volume: 104 Issue: 3 Pages: 1917-1929
- DOI
  10.1007/s00277-025-06269-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07935
[Journal Article] Maternal smoking during infancy increases the risk of allergic diseases in children: a nationwide longitudinal survey in Japan.2025
- Author(s)
  Shigehara K, Matsumoto N, Tsuge M, Uda K, Saito Y, Yashiro M, Yorifuji T, Ikeda M, Tsukahara H.
- Journal Title
  
  Allergy Asthma Clin Immunol.
  
  Volume: 21 Issue: 1 Pages: 4-4
- DOI
  10.1186/s13223-025-00952-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07820, KAKENHI-PROJECT-22K07935
[Journal Article] Impact of Birth Order on Paediatric Allergic Diseases: A National Birth Cohort in Japan2025
- Author(s)
  Kobayashi Mitsuro、Ikeda Masanori、Matsumoto Naomi、Tsuge Mitsuru、Yashiro Masato、Yorifuji Takashi、Tsukahara Hirokazu
- Journal Title
  
  Clinical & Experimental Allergy
  
  Volume: - Issue: 6 Pages: 508-510
- DOI
  10.1111/cea.14626
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07935
[Journal Article] Increased Oxidative Stress and Decreased Citrulline in Blood Associated with Severe Novel Coronavirus Pneumonia in Adult Patients.2024
- Author(s)
  Tsuge M, Ichihara E, Hasegawa K, Kudo K, Tanimoto Y, Nouso K, Oda N, Mitsumune S, Kimura G, Yamada H, Takata I, Mitsuhashi T, Taniguchi A, Tsukahara K, Aokage T, Hagiya H, Toyooka S, Tsukahara H, Maeda Y.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 25 Issue: 15 Pages: 8370-8370
- DOI
  10.3390/ijms25158370
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07820, KAKENHI-PROJECT-22K07935
[Journal Article] Impacts of routine varicella vaccination program and COVID-19 pandemic on varicella and herpes zoster incidence and health resource use among children in Japan2023
- Author(s)
  Uda K, Okubo Y, Tsuge M, Tsukahara H, Miyairi I
- Journal Title
  
  Vaccine
  
  Volume: 41（34） Issue: 34 Pages: 4958-4966
- DOI
  10.1016/j.vaccine.2023.06.054
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07820, KAKENHI-PROJECT-22K07935
[Journal Article] Need for re-evaluating the risk of coronavirus disease 2019 transmission to neonates2023
- Author(s)
  Uda K, Tsuge M, Yashiro M, Honda T, Tsukahara H
- Journal Title
  
  Pediatr Int
  
  Volume: 65（1） Issue: 1
- DOI
  10.1111/ped.15460
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07820, KAKENHI-PROJECT-22K07935, KAKENHI-PROJECT-21H02738
[Journal Article] Roles of Oxidative Injury and Nitric Oxide System Derangements in Kawasaki Disease Pathogenesis: A Systematic Review2023
- Author(s)
  Tsuge M, Uda K, Eitoku T, Matsumoto N, Yorifuji T, Tsukahara H
- Journal Title
  
  Int J Mol Sci
  
  Volume: 24（20） Issue: 20 Pages: 15450-15450
- DOI
  10.3390/ijms242015450
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07820, KAKENHI-PROJECT-22K07935
[Journal Article] Successful use of dupilumab for egg-induced eosinophilic gastroenteritis with duodenal ulcer: a pediatric case report and review of literature2023
- Author(s)
  Tsuge Mitsuru、Shigehara Kenji、Uda Kazuhiro、Kawano Seiji、Iwamuro Masaya、Saito Yukie、Yashiro Masato、Ikeda Masanori、Tsukahara Hirokazu
- Journal Title
  
  Allergy, Asthma & Clinical Immunology
  
  Volume: 19 Issue: 1 Pages: 103-103
- DOI
  10.1186/s13223-023-00859-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07935
[Journal Article] Evaluation of the association of birth order and group childcare attendance with Kawasaki disease using data from a nationwide longitudinal survey2023
- Author(s)
  Namba T, Takeuchi A, Matsumoto N, Tsuge M, Yashiro M, Tsukahara H, Yorifuji T
- Journal Title
  
  Front Pediatr
  
  Volume: 11 Pages: 1127053-1127053
- DOI
  10.3389/fped.2023.1127053
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07820, KAKENHI-PROJECT-22K07935, KAKENHI-PROJECT-20K10498
[Journal Article] Decreased Levels of Histidine-Rich Glycoprotein and Increased Levels of High-Mobility Group Box 1 are Risk Factors for Refractory Kawasaki Disease2022
- Author(s)
  Namba T, Yashiro M, Fujii Y, Tsuge M, Liu K, Nishibori M, Tsukahara H
- Journal Title
  
  Mod Rheumatol
  
  Volume: - Issue: 3 Pages: 599-607
- DOI
  10.1093/mr/roac040
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07822, KAKENHI-PROJECT-22K07935, KAKENHI-PROJECT-22K07820
[Journal Article] 新生児領域における酸化ストレス制御の意義2022
- Author(s)
  塚原宏一、宮原宏幸、鷲尾洋介、津下充、馬場健児
- Journal Title
  
  日本小児高血圧研究会誌
  
  Volume: 18 Pages: 10-18
- Data Source
  KAKENHI-PROJECT-22K07820
[Journal Article] Correlation between national surveillance and search engine query data on respiratory syncytial virus infections in Japan2022
- Author(s)
  Uda K, Hagiya H, Yorifuji T, Koyama T, Tsuge M, Yashiro M, Tsukahara H
- Journal Title
  
  BMC Public Health
  
  Volume: 22 Issue: 1 Pages: 1517-1517
- DOI
  10.1186/s12889-022-13899-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07820, KAKENHI-PROJECT-22K07935, KAKENHI-PROJECT-22K10415
[Journal Article] Novel Lung Growth Strategy with Biological Therapy Targeting Airway Remodeling in Childhood Bronchial Asthma2022
- Author(s)
  Tsuge M, Ikeda M, Tsukahara H
- Journal Title
  
  Children (Basel)
  
  Volume: 9 Issue: 8 Pages: 1253-1253
- DOI
  10.3390/children9081253
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07820, KAKENHI-PROJECT-22K07935
[Journal Article] Severe pediatric asthma with a poor response to omalizumab: a report of three cases and three-dimensional bronchial wall analysis2022
- Author(s)
  Tsuge Mitsuru、Ikeda Masanori、Kondo Yoichi、Tsukahara Hirokazu
- Journal Title
  
  Journal of International Medical Research
  
  Volume: 50 Issue: 1 Pages: 1-10
- DOI
  10.1177/03000605211070492
- NAID
  120007183226
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08278
[Journal Article] Neonatal hemochromatosis with εγδβ-thalassemia: a case report and analysis of serum iron regulators2022
- Author(s)
  Tsuge Mitsuru、Kodera Aya、Sumitomo Hiromi、Araki Tooru、Yoshida Ryuichi、Yasui Kazuya、Sato Hiroki、Washio Yosuke、Washio Kana、Shigehara Kenji、Yashiro Masato、Yagi Takahito、Tsukahara Hirokazu
- Journal Title
  
  BMC Pediatrics
  
  Volume: 22 Issue: 1
- DOI
  10.1186/s12887-022-03706-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07935
[Journal Article] Anaphylaxis after jellyfish ingestion with no history of stings: a pediatric case report2021
- Author(s)
  Tsuge Mitsuru、Ikeda Masanori、Mitani Osamu、Yasui Masato、Tsukahara Hirokazu
- Journal Title
  
  Allergy, Asthma & Clinical Immunology
  
  Volume: 17 Issue: 1 Pages: 99-99
- DOI
  10.1186/s13223-021-00601-x
- NAID
  120007161118
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08278
[Journal Article] COVID-19 in Okayama Prefecture: Looking back and looking forward2021
- Author(s)
  Tsukahara Hirokazu、Higashionna Tsukasa、Tsuge Mitsuru、Miyamura Junko、Kusano Nobuchika
- Journal Title
  
  Global Health & Medicine
  
  Volume: 3 Issue: 2 Pages: 102-106
- DOI
  10.35772/ghm.2020.01104
- NAID
  130008036363
- ISSN
  2434-9186, 2434-9194
- Year and Date
  2021-04-30
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08278
[Journal Article] Reactive Oxygen Species and Antioxidative Defense in Chronic Obstructive Pulmonary Disease2021
- Author(s)
  Taniguchi A, Tsuge M, Miyahara N, Tsukahara H
- Journal Title
  
  Antioxidants (Basel)
  
  Volume: 28;10(10) Issue: 10 Pages: 1537-1537
- DOI
  10.3390/antiox10101537
- NAID
  120007170512
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08277, KAKENHI-PROJECT-19K08278
[Journal Article] Terry’s nails in an infant with liver cirrhosis2021
- Author(s)
  Uda Kazuhiro、Tsuge Mitsuru、Shigehara Kenji、Yashiro Masato、Tsukahara Hirokazu
- Journal Title
  
  Archives of Disease in Childhood
  
  Volume: 107 Issue: 5 Pages: 485-485
- DOI
  10.1136/archdischild-2021-322953
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08278
[Journal Article] Anti-high mobility group box 1 monoclonal antibody suppressed hyper-permeability and cytokine production in human pulmonary endothelial cells infected with influenza A virus2021
- Author(s)
  Namba T, Tsuge M, Yashiro M, Saito Y, Liu K, Nishibori M, Morishima T, Tsukahara H
- Journal Title
  
  Inflamm Res
  
  Volume: 70(10-12) Issue: 10-12 Pages: 1101-1111
- DOI
  10.1007/s00011-021-01496-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08277, KAKENHI-PROJECT-19K08278, KAKENHI-PROJECT-19H03408
[Journal Article] Current Insights into Atopic March2021
- Author(s)
  Tsuge M, Ikeda M, Matsumoto N, Yorifuji T, Tsukahara H
- Journal Title
  
  Children (Basel)
  
  Volume: 19;8(11) Issue: 11 Pages: 1067-1067
- DOI
  10.3390/children8111067
- NAID
  120007180266
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08277, KAKENHI-PROJECT-19K08278
[Journal Article] Gene expression analysis in children with complex seizures due to influenza A(H1N1)pdm09 or rotavirus gastroenteritis，2014
- Author(s)
  Tsuge M1, Oka T, Yamashita N, Saito Y, Fujii Y, Nagaoka Y, Yashiro M, Tsukahara H, Morishima T.
- Journal Title
  
  J Neurovirol.
  
  Volume: 20 Issue: 1 Pages: 73-84
- DOI
  10.1007/s13365-013-0231-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460437, KAKENHI-PROJECT-25461594, KAKENHI-PROJECT-25670465
[Journal Article] Pathogenic mechanisms of influenza A(H1N1)pdm09 infection elucidated on gene expression profiling.2013
- Author(s)
  Yamashita N, Tsukahara H, Tsuge M, Nagaoka Y, Yashiro M, Saito Y, Fujii Y, Oka T, Morishima T.
- Journal Title
  
  Pediatr Int.
  
  Volume: 55 Pages: 572-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670465
[Presentation] 突発性発疹関連脳症における免疫応答に関連した宿主遺伝子発現解析2024
- Author(s)
  津下充, 濃野優, 宇田和宏, 茂原研司, 塚原宏一
- Organizer
  第56回日本小児感染症学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-22K07935
[Presentation] インフルエンザA(H1N1)pdm09による急性呼吸窮迫症候群に対して体外式膜型人工肺とペラミビル・バロキサビルマルボキシル併用療法で改善した一例2020
- Author(s)
  津下充, 茂原研司, 斎藤有希惠, 八代将登, 塚原宏一
- Organizer
  第52回日本小児感染症学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08278
[Presentation] 肺血管内皮細胞を用いた重症インフルエンザ肺炎モデルの構築と high mobility group box 1抗体による肺血管透過性亢進の抑制効果2020
- Author(s)
  難波貴弘, 津下充, 八代将登, 塚原宏一, 森島恒雄
- Organizer
  第61回日本臨床ウイルス学会
- Data Source
  KAKENHI-PROJECT-19K08278
[Presentation] ヒト脳血管内皮細胞を用いた高サイトカイン血症モデルにおけるhigh mobility group box-1抗体の血管透過性抑制効果2019
- Author(s)
  津下　充，難波貴弘，西堀正洋，斎藤有希恵，八代将登，塚原宏一，森島恒雄
- Organizer
  第51回日本小児感染症学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08278
[Presentation] 痙攣重責を示したインフルエンザA（H1N1）pdm及びロタウイルス胃腸炎の宿主遺伝子発現の解析2014
- Author(s)
  津下　充
- Organizer
  第46回日本小児感染症学会
- Place of Presentation
  東京　京王プラザホテル
- Year and Date
  2014-10-19
- Data Source
  KAKENHI-PROJECT-25670465

1. Tsukahara Hirokazu (90207340)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
2. MORISHIMA Tsuneo (90157892)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. FUJI Yousuke (80549775)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 鷲尾洋介 (20569066)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 妹尾朋香 (70768069)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 玉井圭 (90600396)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 森本大作 (90866245)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. OKA Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 西堀正洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 宮原宏幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 伊藤佐智夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TSUGE MITSURU 津下 充

TSUGE Mitsuru 津下 充

津下 充 ツゲ ミツル

Research Projects

Research Products

Co-Researchers

早産児晩期循環不全の新しい予防・治療戦略に向けた病態解明と予測マーカーの開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of pathogenesis and preventive measures for complications in pediatric COVID-19

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel treatments for influenza-associated encephalopathy by regulating IL-1 receptor and Toll-like receptor signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Search for new treatments for influenza associated encephalopathy targeting innate immune mediatorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of the therapeutic agent for the treatment of highly pathogenic influenza

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

痙攣重積型インフルエンザ脳症の病態解析と新規治療薬の検索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Influenza: Advances in Diagnosis and Management2020

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] A randomized controlled trial of conventional GVHD prophylaxis with or without teprenone for the prevention of severe acute GVHD2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Maternal smoking during infancy increases the risk of allergic diseases in children: a nationwide longitudinal survey in Japan.2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of Birth Order on Paediatric Allergic Diseases: A National Birth Cohort in Japan2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Increased Oxidative Stress and Decreased Citrulline in Blood Associated with Severe Novel Coronavirus Pneumonia in Adult Patients.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impacts of routine varicella vaccination program and COVID-19 pandemic on varicella and herpes zoster incidence and health resource use among children in Japan2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Need for re-evaluating the risk of coronavirus disease 2019 transmission to neonates2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Roles of Oxidative Injury and Nitric Oxide System Derangements in Kawasaki Disease Pathogenesis: A Systematic Review2023

Author(s)

Journal Title

TSUGE MITSURU 津下充

TSUGE Mitsuru 津下充

津下充ツゲミツル