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ISHIKAWA Hideaki  石川 英明

Researcher Number 80625715
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-2989-8411
Affiliation *help 2017 – 2018 : 東京農工大学, (連合)農学研究科(研究院), 特任助教
2012 – 2016 : 東京農工大学, (連合)農学研究科(研究院), 助教
2015 : 東京農工大学, 大学院農学府, 特任助教
2014 : 東京農工大学, 大学院農学研究院, 助教
Review Section/Research Field
Principal Investigator
Molecular biology
Except Principal Investigator
Chemical biology / Plant molecular biology/Plant physiology
Keywords
Principal Investigator
転写後修飾 / RNA / 分子間相互作用 / RNA品質管理機構 / リボヌクレオプロテオミクス
Except Principal Investigator
エピジェネティクス / DCL4 / DCL3 / ガン治療 / エピジェンティック … More / 2本鎖RNA / リボソームRNAのプロセシング / 基質特異性 / 抗がん薬 / リボソームRNAプロセシング / 機能プロテオミクス / 小分子RNA / タンパク質相互作用 / DCL4 / DCL3 / RNA干渉 / プロテオミクス / シロイヌナズナ / 医薬品探査 / ケミカルバイオロジー / ダイサー / 栄養欠乏ストレス / がん / 転写抑制 / エピジェンティクス Less
  • Research Projects

    (3results)
  • Research Products

    (23results)
  • Co-Researchers

    (15People)
  •  Exploration of quality control mechanism during U snRNA / snRNP biogenesis processPrincipal Investigator

    • Principal Investigator
      石川 英明
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Molecular biology
    • Research Institution
      Tokyo University of Agriculture and Technology
  •  Search for drugs targeted against the LYAR cell growth factor

    • Principal Investigator
      Takahashi Nobuhiro
    • Project Period (FY)
      2012 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Chemical biology
    • Research Institution
      Tokyo University of Agriculture and Technology
  •  Enzymatic properties and functional divergence of plant Dicers

    • Principal Investigator
      FUKUHARA Toshiyuki
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Plant molecular biology/Plant physiology
    • Research Institution
      Tokyo University of Agriculture and Technology

All 2018 2017 2015 2014 2013 2012 Other

All Journal Article Presentation

  • [Journal Article] Truncated forms of U2 snRNA (U2-tfs) are shunted toward a novel uridylylation pathway that differs from the degradation pathway for U1-tfs.2018

    • Author(s)
      Ishikawa H, Nobe Y, Izumikawa K, Taoka M, Yamauchi Y, Nakayama H, Simpson RJ, Isobe T, Takahashi N.
    • Journal Title

      RNA Biology

      Volume : 15 Pages : 261-268

    • DOI
      10.1080/15476286.2017.1408766
    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K18489
  • [Journal Article] TDP-43 stabilises the processing intermediates of mitochondrial transcripts.2017

    • Author(s)
      Izumikawa K, Nobe Y, Yoshikawa H, Ishikawa H, Miura Y, Nakayama H, Nonaka T, Hasegawa M, Egawa N, Inoue H, Nishikawa K, Yamano K, Simpson RJ, Taoka M, Yamauchi Y, Isobe T, Takahashi N
    • Journal Title

      Sci Rep

      Volume : 7 Pages : 7709-7709

    • Publisher
      Springer Nature
    • DOI
      10.1038/s41598-017-06953-y
    • ISSN
      2045-2322
    • Year and Date
      2017-08-09
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356, KAKENHI-PROJECT-16K18489
  • [Journal Article] Poly(A)-specific ribonuclease regulates the processing of small-subunit rRNAs in human cells.2017

    • Author(s)
      Ishikawa H., Yoshikawa H., Izumikawa K., Miura Y., Taoka M., Nobe Y., Yamauchi Y., Nakayama H., Simpson R. J., Isobe T. and Takahashi N..
    • Journal Title

      Nucleic Acids Res.

      Volume : 45 Pages : 3437-3447

    • DOI
      10.1093/nar/gkw1047
    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26500003, KAKENHI-PROJECT-16K18489
  • [Journal Article] Human nucleolar protein Nop52 (RRP1/NNP-1) is involved in site 2 cleavage in internal transcribed spacer 1 of pre-rRNAs at early stages of ribosome biogenesis.2015

    • Author(s)
      Yoshikawa H, Ishikawa H, Izumikawa K, Miura Y, Hayano T, Isobe T, Simpson RJ, Takahashi N.
    • Journal Title

      Nucleic Acids Res.

      Volume : 43 Pages : 5524-5536

    • DOI
      10.1093/nar/gkv470
    • Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26500003, KAKENHI-PROJECT-24241075
  • [Journal Article] 質量分析法を利用したRNA-タンパク質複合体のトータル解析2015

    • Author(s)
      泉川桂一、石川英明、吉川治孝、礒辺俊明、高橋信弘
    • Journal Title

      生物と化学

      Volume : 53 Pages : 850-859

    • DOI
      10.1271/kagakutoseibutsu.53.850
    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24241075
  • [Journal Article] Human nucleolar protein Nop52 (RRP1/NNP-1) is involved in site 2 cleavage in internal transcribed spacer 1 of pre-rRNAs at early stages of ribosome biogenesis.2015

    • Author(s)
      Yoshikawa H., Ishikawa H., Izumikawa K., Miura Y., Hayano T., Isobe T., Simpson R.J. and Takahashi N.
    • Journal Title

      Nucleic Acids Research

      Volume : in press

    • Open Access / Acknowledgement Compliant / Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24241075
  • [Journal Article] Collaborator of alternative reading frame protein (CARF) regulates early processing of pre-ribosomal RNA by retaining XRN2 (5’-3’ exoribonuclease) in the nucleoplasm.2015

    • Author(s)
      Sato+, S., Ishikawa+, H., Yoshikawa, H., Izumikawa, K., Simpson, R.J. and Takahashi, N.
    • Journal Title

      Nucleic Acids Res.

      Volume : 43 Pages : 10397-10397

    • DOI
      10.1093/nar/gkv1069
    • Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24241075
  • [Journal Article] Human cell growth regulator Ly-1 antibody reactive homolog accelerates processing of pre-ribosomal RNA2014

    • Author(s)
      Miyazawa N., Yoshikawa, H., Magae S., Ishikawa H., Izumikawa K., Terukina G., Suzuki A, Nakamura-Fujiyama S., Miura Y., Hayano T, Komatsu K., Isobe T, and Takahashi N.
    • Journal Title

      Genes to Cells

      Volume : 19 Pages : 273-286

    • DOI
      10.1111/gtc.12129
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24241075
  • [Journal Article] RNA cytidine acetyltransferase of small-subunit ribosomal RNA: identification of acetylation sites and the responsible acetyltransferase in fission yeast, Schizosaccharomyces pombe.2014

    • Author(s)
      Taoka M, Ishikawa D, Nobe Y, Ishikawa H, Yamauchi Y, Terukina G, Nakayama H, Hirota K, Takahashi N, Isobe T
    • Journal Title

      PLoS One.

      Volume : 9

    • DOI
      10.1371/journal.pone.0112156
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-24241075, KAKENHI-PROJECT-25281021, KAKENHI-PUBLICLY-26116518
  • [Presentation] U snRNP生合成過程における品質管理機構2017

    • Author(s)
      石川 英明、泉川 桂一、延 優子、礒辺 俊明、高橋 信弘
    • Organizer
      第19回日本RNA学会年会
    • Data Source
      KAKENHI-PROJECT-16K18489
  • [Presentation] Human cell growth regulator LYAR is highly expressed in many tumors and accelerates ribosome biogenesis.2013

    • Author(s)
      Izumikawa, K., Miyazawa, N., Yoshikawa, H., Ishikawa, H., Terukina, G., Miura, Y., Hayano, T., Isobe, T., Watanabe, A., Aburatani, H., Takahashi, N.
    • Organizer
      HUPO 12th Annual Wold Congress-JHUPO 2013 Anual Joint Congress
    • Place of Presentation
      Yokohama
    • Data Source
      KAKENHI-PROJECT-24241075
  • [Presentation] The Role of Nucleolar Protein Nop52 in the pre-rRNA Processing During Human Ribosome Biogenesis by Proteomic Approach2013

    • Author(s)
      Yoshikawa, H., Ishikawa, H., Izumikawa, K., Hayano, T., Miura, Y., Yamauchi, Y., Isobe, T., Takahashi, N.
    • Organizer
      HUPO 12th Annual Wold Congress-JHUPO 2013 Anual Joint Congress
    • Place of Presentation
      Yokohama
    • Data Source
      KAKENHI-PROJECT-24241075
  • [Presentation] ヒトリボソーム40Sサブユニット生合成におけるPARNタンパク質の役割2013

    • Author(s)
      石川英明、泉川桂一、吉川治孝、礒辺俊明、高橋信弘(高橋信弘)
    • Organizer
      第2回RIBOSOME MEETING
    • Place of Presentation
      東京、東京農工大学農学部
    • Data Source
      KAKENHI-PROJECT-24241075
  • [Presentation] 癌抑制因子Arfの相互作用タンパク質CARFの細胞増殖における新規機能2012

    • Author(s)
      佐藤慈子、石川英明、泉川桂一、高橋信弘(高橋信弘)
    • Organizer
      日本プロテオーム学会2012大会(10th JHUPO conference)
    • Place of Presentation
      東京、日本科学未来館
    • Data Source
      KAKENHI-PROJECT-24241075
  • [Presentation] プロテオミクスの手法を用いた核小体タンパク質Nop52のヒトリボソーム生合成における役割の解明2012

    • Author(s)
      吉川治孝、川崎実由希、早野俊哉、泉川桂一、石川英明、山内芳雄、礒辺俊明、高橋信弘(高橋信弘)
    • Organizer
      日本プロテオーム学会2012大会(10th JHUPO conference)
    • Place of Presentation
      東京、日本科学未来館
    • Data Source
      KAKENHI-PROJECT-24241075
  • [Presentation] 多種類の腫瘍細胞で高発現しているヒト細胞増殖因子LYARはリボソーム生合成を昂進している2012

    • Author(s)
      宮澤直樹、吉川治孝、馬替恵美、石川英明、泉川桂一、照喜名悟朗、鈴木愛、藤山-中村沙理1、三浦豊、早野俊哉、礒辺俊明、渡辺亮、油谷裕幸、高橋信弘(高橋信弘)
    • Organizer
      日本プロテオーム学会2012大会(10th JHUPO conference)
    • Place of Presentation
      東京、日本科学未来館
    • Data Source
      KAKENHI-PROJECT-24241075
  • [Presentation] ガン細胞に特異的なリボソーム合成促進因子をターゲットとした細胞増殖阻害物質探索法の開発

    • Author(s)
      泉川桂一、吉川治孝、石川英明、高橋信弘
    • Organizer
      東京バイオマーカー・イノベーション技術組合 TOBIRA研究交流フォーラム
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24241075
  • [Presentation] Comprehensive mass spectrometry-based structural determination of small subunit ribosomal RNA: Characterization of N4-acetylcytidine and identification of the responsible enzyme.

    • Author(s)
      Masato Taoka; Daisuke Ishikawa; Yuko Nobe; Hideaki Ishikawa; Hiroshi Nakayama; Yoshio Yamauchi; Nobuhiro Takahashi; Toshiaki Isobe
    • Organizer
      62nd ASMS Conference on Mass Spectrometry and Allied Topics
    • Place of Presentation
      Baltimore Convention Center, USA
    • Year and Date
      2014-06-15 – 2014-06-19
    • Data Source
      KAKENHI-PROJECT-24241075
  • [Presentation] ヒト細胞増殖因子LYARは多種類の腫瘍細胞で高発現しておりリボソーム合成を昂進している

    • Author(s)
      吉川治孝、宮澤直樹、馬替恵美、石川英明、泉川桂一、照喜名悟朗、三浦豊、早野俊哉、礒辺俊明、渡辺亮、油谷裕幸、高橋信弘
    • Organizer
      日本プロテオーム学会2014(JHUPO2014)
    • Place of Presentation
      つくば国際会議場、筑波
    • Year and Date
      2014-07-14 – 2014-07-15
    • Data Source
      KAKENHI-PROJECT-24241075
  • [Presentation] 細胞増殖制御因子hLARのリボソーム生合成経路における機能解析

    • Author(s)
      泉川桂一、宮澤直樹、石川英明、吉川治孝、長橋花織、高橋信弘
    • Organizer
      第三回リボソームミーティング
    • Place of Presentation
      ANAホリデイ・イン リゾート 宮崎
    • Year and Date
      2015-03-17 – 2015-03-18
    • Data Source
      KAKENHI-PROJECT-24241075
  • [Presentation] プロテオミクスによるヒトのリボソーム合成過程の解析

    • Author(s)
      吉川治孝、石川英明、泉川桂一、高橋信弘
    • Organizer
      第三回リボソームミーティング
    • Place of Presentation
      ANAホリデイ・イン リゾート 宮崎
    • Year and Date
      2015-03-17 – 2015-03-18
    • Data Source
      KAKENHI-PROJECT-24241075
  • [Presentation] リボヌクレアーゼを介したヒトリボソーム生合成調節機構

    • Author(s)
      石川英明、佐藤慈子、泉川桂一、吉川治孝3、礒辺俊明、高橋信弘
    • Organizer
      第三回リボソームミーティング
    • Place of Presentation
      ANAホリデイ・イン リゾート 宮崎
    • Year and Date
      2015-03-17 – 2015-03-18
    • Data Source
      KAKENHI-PROJECT-24241075
  • [Presentation] リボヌクレオプロテオミクスによる疾患解析

    • Author(s)
      高橋信弘、石川英明、泉川桂一、中山洋、田岡万悟、礒辺俊明(高橋信弘)
    • Organizer
      第8回臨床プロテオーム研究会
    • Place of Presentation
      東京、都市センターホテル
    • Invited
    • Data Source
      KAKENHI-PROJECT-24241075
  • 1.  IZUMIKAWA Keiichi (60625713)
    # of Collaborated Projects : 2results
    # of Collaborated Products : 17results
  • 2.  Takahashi Nobuhiro (80293017)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 19results
  • 3.  MIURA Yutaka (10219595)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 8results
  • 4.  YOSHIKAWA Harunori (60709567)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 15results
  • 5.  ISOBE Toshiaki (70106607)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 14results
  • 6.  FUKUHARA Toshiyuki (90228924)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 7.  HABU Yoshiki (80266915)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 8.  YOSHIKAWA Manabu (80391564)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 9.  ISHII Kazuo (60449238)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 10.  KOZAKI Toshinori (60442828)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 11.  NAGANO Hideaki
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 12.  SETA Atsushi
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 13.  TAKAHASHI Ryosuke
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
  • 14.  HIROTA Kouji
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
  • 15.  長谷川 成人
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results

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