MIZUTANI TOMOHIRO 水谷知裕

… Alternative Names

Mizutani Tomohiro 水谷知裕

MIZUTANI Tomohiro 水谷知裕

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Researcher Number	80632588
Other IDs	https://orcid.org/0000-0002-8373-7969
Affiliation (Current)	2023: 東京医科歯科大学, 大学院医歯学総合研究科, 講師
Affiliation (based on the past Project Information) *help	2022 – 2023: 東京医科歯科大学, 大学院医歯学総合研究科, 講師 2022: 東京医科歯科大学, 東京医科歯科大学病院, 助教 2020 – 2022: 東京医科歯科大学, 医学部附属病院, 助教 2013 – 2014: 東京医科歯科大学, 医歯(薬)学総合研究科, 特任助教
Review Section/Research Field	Principal Investigator Gastroenterology / 0903:Organ-based internal medicine and related fields / Basic Section 53010:Gastroenterology-related Except Principal Investigator Medium-sized Section 52:General internal medicine and related fields / Basic Section 53010:Gastroenterology-related / Medium-sized Section 53:Organ-based internal medicine and related fields
Keywords	Principal Investigator 腸管スフェロイド / iPS細胞 / 腸管グラフト / 自己組織化 / 腸管上皮培養 / 低分子化合物 / GMP規格 / 再生医療 / 下部消化管学（小腸、大腸） / 人工ペプチド / 短腸症候群 / 炎症性腸疾患 / 難治性腸炎 … More Except Principal Investigator … More 炎症性腸疾患 / オルガノイド / 短腸症候群 / 多能性幹細胞 / 体性幹細胞 / ディスプラジア / 移植 / double negative T細胞 / 抗原提示細胞 / 腸管免疫 / アナジー Less

難治性消化管疾患に対する統合オルガノイド医療の創成
- Principal Investigator
  
  岡本隆一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Tokyo Medical and Dental University
患者由来大腸オルガノイド移植法を用いたdysplasia-PDOXモデルの開発
- Principal Investigator
  
  福田将義
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
疾患／臓器／領域レベルでのアナジー誘導性抗原提示細胞；DNT細胞研究の拡大
- Principal Investigator
  
  根本泰宏
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Tokyo Medical and Dental University
ヒトiPS細胞由来複合型自己組織化腸管組織を用いた難治性腸炎モデルの確立Principal Investigator
- Principal Investigator
  
  水谷知裕
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
Development of intestinal graft production and transplantation method using human iPS cell-derived self-organization intestinal organoids.Principal Investigator
- Principal Investigator
  
  Mizutani Tomohiro
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0903:Organ-based internal medicine and related fields
- Research Institution
  Tokyo Medical and Dental University
Establishment of a xeno-free primary culture method for human colonic epithelial stem cellsPrincipal Investigator
- Principal Investigator
  
  MIZUTANI Tomohiro
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University

All 2021 2014 2013

All Journal Article Presentation

[Journal Article] Functional analysis of isoflavones using patient-derived human colonic organoids2021
- Author(s)
  Tsuchiya Mao、Ito Go、Hama Minami、Nagata Sayaka、Kawamoto Ami、Suzuki Kohei、Shimizu Hiromichi、Anzai Sho、Takahashi Junichi、Kuno Reiko、Takeoka Sayaka、Hiraguri Yui、Sugihara Hady Yuki、Mizutani Tomohiro、Yui Shiro、Oshima Shigeru、Tsuchiya Kiichiro、Watanabe Mamoru、Okamoto Ryuichi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 542 Pages: 40-47
- DOI
  10.1016/j.bbrc.2021.01.021
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21597, KAKENHI-PROJECT-20K22895, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-19H03634, KAKENHI-PROJECT-20H03657, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-19K17484, KAKENHI-PROJECT-19K23990, KAKENHI-PROJECT-20K22920, KAKENHI-PROJECT-21H02895, KAKENHI-PROJECT-21K15992
[Journal Article] Intraepithelial Lymphocytes Suppress Intestinal Tumor Growth by Cell-to-Cell Contact via CD103/E-Cadherin Signal.2021
- Author(s)
  Ryo Morikawa, Yasuhiro Nemoto, Yuki Yonemoto, Shohei Tanaka, Yuria Takei, Shigeru Oshima, Takashi Nagaishi, Kiichiro Tsuchiya, Kengo Nozaki , Tomohiro Mizutani, Tetsuya Nakamura, Mamoru Watanabe, Ryuichi Okamoto.
- Journal Title
  
  Cell Mol Gastroenterol Hepatol.
  
  Volume: 11 Issue: 5 Pages: 1483-1503
- DOI
  10.1016/j.jcmgh.2021.01.014
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08364, KAKENHI-PROJECT-19K08388, KAKENHI-PROJECT-19K08438, KAKENHI-PROJECT-20K08304, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-18H02790, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-20H03658, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-18K07964, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-19K08461, KAKENHI-PROJECT-20K22920, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-21H02895, KAKENHI-PROJECT-21H02897, KAKENHI-PROJECT-21H02898
[Journal Article] Notch and TNF-α signaling promote cytoplasmic accumulation of OLFM4 in intestinal epithelium cells and exhibit a cell protective role in the inflamed mucosa of IBD patients2021
- Author(s)
  Kuno Reiko、Ito Go、Kawamoto Ami、Hiraguri Yui、Sugihara Hady Yuki、Takeoka Sayaka、Nagata Sayaka、Takahashi Junichi、Tsuchiya Mao、Anzai Sho、Mizutani Tomohiro、Shimizu Hiromichi、Yui Shiro、Oshima Shigeru、Tsuchiya Kiichiro、Watanabe Mamoru、Okamoto Ryuichi
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 25 Pages: 100906-100906
- DOI
  10.1016/j.bbrep.2020.100906
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21597, KAKENHI-PROJECT-20K22895, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-19H03634, KAKENHI-PROJECT-20H03657, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-19K17484, KAKENHI-PROJECT-19K23990, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-20K22920, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-21H02895, KAKENHI-PROJECT-21K15992
[Journal Article] Fluorescent labelling of intestinal epithelial cells reveals independent long-lived intestinal stem cells in a crypt.2014
- Author(s)
  N. Horita, K. Tsuchiya, R. Hayashi, K. Fukushima, S. Hibiya, M. Fukuda, Y. Kano, T. Mizutani, Y. Nemoto, S. Yui, R. Okamoto, T. Nakamura, M. Watanabe
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 454 Issue: 4 Pages: 493-499
- DOI
  10.1016/j.bbrc.2014.10.091
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-24590935, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25670367, KAKENHI-PROJECT-25860524, KAKENHI-PROJECT-26221307
[Journal Article] Hes1 promotes the IL-22-mediated antimicrobial response by enhancing STAT3-dependent transcription in human intestinal epithelial cells2014
- Author(s)
  Murano T, Okamoto R, Ito G, Nakata T, Hibiya S, Shimizu H, Fujii S, Kano Y, Mizutani T, Yui S, Akiyama-Morio J, Nemoto Y, Tsuchiya K, Nakamura T, Watanabe M
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 443 Issue: 3 Pages: 840-846
- DOI
  10.1016/j.bbrc.2013.12.061
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590935, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25670367, KAKENHI-PROJECT-25860524, KAKENHI-PROJECT-26221307
[Journal Article] Distinct expression patterns of Notch ligands, Dll1 and Dll4, in normal and inflamed mice intestine.2014
- Author(s)
  Shimizu H, Okamoto R, Ito G, Nakata T, Suzuki K, Murano T, Mizutani T, Tsuchiya K, Nakamura T, Hozumi K, Watanabe M.
- Journal Title
  
  PeerJ
  
  Volume: 2 Pages: e370-e370
- DOI
  10.7717/peerj.370
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-24590935, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25860524
[Journal Article] Small intestinal stem cell identity is maintained with functional Paneth cells in heterotopically grafted epithelium onto the colon2014
- Author(s)
  Fukuda M, Mizutani T, Mochizuki W, Matsumoto T, Nozaki K, Sakamaki Y, Ichinose S, Okada Y, Tanaka T, Watanabe M, Nakamura T
- Journal Title
  
  Genes & Development
  
  Volume: 28(16) Issue: 16 Pages: 1752-1757
- DOI
  10.1101/gad.245233.114
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390186, KAKENHI-PROJECT-24590936, KAKENHI-PROJECT-25670106, KAKENHI-PROJECT-25670367, KAKENHI-PROJECT-25860524, KAKENHI-PUBLICLY-26112705, KAKENHI-PROJECT-26221307
[Journal Article] Lineage-specific expression of Bestrophin-2 and Bestrophin-4 in human intestinal epithelial cells.2013
- Author(s)
  Ito G, Okamoto R, Nakamura T, Watanabe M et al
- Journal Title
  
  PloS One.
  
  Volume: 8 Issue: 11 Pages: e79693-e79693
- DOI
  10.1371/journal.pone.0079693
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229005, KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-24590935, KAKENHI-PROJECT-24590936, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25460945, KAKENHI-PROJECT-25461031, KAKENHI-PROJECT-25670367, KAKENHI-PROJECT-25860524
[Presentation] Successful Engraftment of Cultured Small Intestinal Epithelial Stem Cells onto Damaged Colonic Mucosa by Heterotopic Transplantation.2014
- Author(s)
  Mizutani T, Fukuda M, Mochizuki W, Matsumoto T, Nozaki K, Ichinose S, Watanabe M, Nakamura T.
- Organizer
  DDW2014
- Place of Presentation
  Chicago,USA
- Year and Date
  2014-05-03
- Data Source
  KAKENHI-PROJECT-25860524
[Presentation] Successful Engraftment of Cultured Small Intestinal Epithelial Stem Cells onto Damaged Colonic Mucosa by Heterotopic Transplantation.2014
- Author(s)
  Fukuda M, Mizutani T, Mochizuki W, Matsumoto T, Nozaki K, Ichinose S, Watanabe M, Nakamura T.
- Organizer
  ISSCR 12th Annual Meeting
- Place of Presentation
  Vancouver,Canada
- Year and Date
  2014-06-19
- Data Source
  KAKENHI-PROJECT-25860524

1. 岡本隆一 (50451935)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
2. 竹中健人 (10783368)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 武部貴則 (20612625)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 福田将義 (00733627)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 根本泰宏 (20456213)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 森川亮 (60910122)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 渡辺守

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
8. 中村哲也

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
9. 永石宇治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 土屋輝一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MIZUTANI TOMOHIRO 水谷 知裕

Mizutani Tomohiro 水谷 知裕

MIZUTANI Tomohiro 水谷 知裕

Research Projects

Research Products

Co-Researchers

難治性消化管疾患に対する統合オルガノイド医療の創成

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

患者由来大腸オルガノイド移植法を用いたdysplasia-PDOXモデルの開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

疾患／臓器／領域レベルでのアナジー誘導性抗原提示細胞；DNT細胞研究の拡大

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ヒトiPS細胞由来複合型自己組織化腸管組織を用いた難治性腸炎モデルの確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of intestinal graft production and transplantation method using human iPS cell-derived self-organization intestinal organoids.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of a xeno-free primary culture method for human colonic epithelial stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Functional analysis of isoflavones using patient-derived human colonic organoids2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intraepithelial Lymphocytes Suppress Intestinal Tumor Growth by Cell-to-Cell Contact via CD103/E-Cadherin Signal.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Notch and TNF-α signaling promote cytoplasmic accumulation of OLFM4 in intestinal epithelium cells and exhibit a cell protective role in the inflamed mucosa of IBD patients2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fluorescent labelling of intestinal epithelial cells reveals independent long-lived intestinal stem cells in a crypt.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hes1 promotes the IL-22-mediated antimicrobial response by enhancing STAT3-dependent transcription in human intestinal epithelial cells2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Distinct expression patterns of Notch ligands, Dll1 and Dll4, in normal and inflamed mice intestine.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Small intestinal stem cell identity is maintained with functional Paneth cells in heterotopically grafted epithelium onto the colon2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lineage-specific expression of Bestrophin-2 and Bestrophin-4 in human intestinal epithelial cells.2013

Author(s)

Journal Title

MIZUTANI TOMOHIRO 水谷知裕

Mizutani Tomohiro 水谷知裕

MIZUTANI Tomohiro 水谷知裕