NEMOTO Wataru 根本亙

Researcher Number	80635136
Other IDs
Affiliation (Current)	2025: 東北医科薬科大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2025: 東北医科薬科大学, 薬学部, 講師 2022 – 2023: 東北医科薬科大学, 薬学部, 講師 2017 – 2022: 東北医科薬科大学, 薬学部, 助教 2016 – 2017: 東北医科薬科大学, 薬学部, 助手 2014 – 2015: 東北薬科大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 47040:Pharmacology-related / General pharmacology Except Principal Investigator Basic Section 47040:Pharmacology-related / Pharmacology in pharmacy / Basic Section 48030:Pharmacology-related
Keywords	Principal Investigator 脊髄 / 疼痛 / アンジオテンシン / 神経障害性疼痛 / 糖尿病 / db/dbマウス / 神経障害 / TNF-α変換酵素 / 炎症性疼痛 / ジミナゼン … More / ACE2 / アンジオテンシン変換酵素2 / 薬理学 / 糖尿病性神経障害性疼痛 / アンジオテンシンII / マウス … More Except Principal Investigator Mas受容体 / 脊髄 / アンジオテンシン変換酵素2 / うつ病 / p38 MAPK / 糖尿病性神経障害性疼痛 / アンジオテンシン / 神経障害性疼痛 / 2型糖尿病 / ob/obマウス / アンジオテンシン (1-7) / 神経新生 / マウス / アンジオテンシンII / ADAM17 / 難治性疼痛 / 海馬 / うつ病動物モデル / アンジオテンシン変換酵素２ / アンジオテンシン１－７ / アンジオテンシン（1-7） / レプチン受容体欠損 (db/db) マウス / アンジオテンシン変換酵素2 (ACE2) / レプチン欠損 (ob/ob) マウス / テルミサルタン / ペリンドプリルエルブミン / Ang (1-7) / アンジオテンシン系 / BDNF / Ang(1-7) / カプトプリル / ACE2 / 機械的アロデニィア / 熱性痛覚過敏 / 接触性痛覚過敏 / ストレプトゾトシン / 嗅球摘出 / スカブロニン / 海馬歯状回 / 嗅球摘出動物 / 記憶障害 / うつ / 動物モデル / 脳由来神経栄養因子 / 認知症 / 抗アロディニア作用 / 1型糖尿病 / ロサルタン / AT1受容体 / アンジオテンシン変換酵素 / アンジオテンシンⅡ / １型糖尿病 / 慢性疼痛 Less

Could the spinal angiotensin system be a novel therapeutic target for intractable pain?
- Principal Investigator
  
  丹野孝一
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
脊髄内TNF-α変換酵素による細胞外領域シェディングを介した疼痛制御機構Principal Investigator
- Principal Investigator
  
  根本亙
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
Functional analysis of angiotensin-converting enzyme 2 in the brain and development of novel therapeutic agents for depression
- Principal Investigator
  
  中川西修
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
Elucidation of neuropathic pain associated with type 2 diabetes mellitus: Involvement of spinal angiotensin system and development of the novel therapeutic agents
- Principal Investigator
  
  Tan-No Koichi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
Role of angiotensin-converting enzyme 2 in neuropathic pain and development of novel therapeutic agentsPrincipal Investigator
- Principal Investigator
  
  Nemoto Wataru
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
Role of brain angiotensin system on animal model of depression
- Principal Investigator
  
  NAKAGAWASAI Osamu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
Elucidation of the mechanism underlying diabetic neuropathic pain and development of its new therapy: Examination from the viewpoint of spinal angiotensin system
- Principal Investigator
  
  Tan-No Koichi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Tohoku Medical and Pharmaceutical University
The elucidation of the involvement of spinal angiotensin II system in intractable pain and the development of new therapyPrincipal Investigator
- Principal Investigator
  
  NEMOTO Wataru
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  Tohoku Medical and Pharmaceutical University
Elucidation of the role of spinal angiotensin system in chronic pain: Aim at developing the new therapy
- Principal Investigator
  
  TAN-NO Koichi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Tohoku Medical and Pharmaceutical University
Development of hippocampal neurogenesis-promoting drugs as a target for the treatment and prevention of psychiatric disorders
- Principal Investigator
  
  NAKAGAWASAI Osamu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Tohoku Medical and Pharmaceutical University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Clinical and preclinical evidence that angiotensin-converting enzyme inhibitors and angiotensin receptor blockers prevent diabetic peripheral neuropathy2024
- Author(s)
  Iwane Shiori、Nemoto Wataru、Miyamoto Tomoyoshi、Hayashi Tomonori、Tanaka Masayuki、Uchitani Kazuki、Muranaka Tatsuya、Fujitani Masanori、Koizumi Yuichi、Hirata Atsushi、Tsubota Maho、Sekiguchi Fumiko、Tan-No Koichi、Kawabata Atsufumi
- Journal Title
  
  Scientific Reports
  
  Volume: 14 Issue: 1 Pages: 1039-1039
- DOI
  10.1038/s41598-024-51572-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06168, KAKENHI-PROJECT-20K07074
[Journal Article] Effect of Globin Digests on Physical Fatigue in Mice2023
- Author(s)
  Nakagawasai Osamu、Yamada Kotaro、Takahashi Kohei、Oshima Yuko、Hayasaka Sena、Shoji Kazuaki、Nemoto Wataru、Tan-No Koichi
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 46 Issue: 7 Pages: 1027-1030
- DOI
  10.1248/bpb.b23-00193
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2023-07-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06866, KAKENHI-PROJECT-21K15351
[Journal Article] Activation of angiotensin-converting enzyme 2 produces an antidepressant-like effect via MAS receptors in mice2023
- Author(s)
  Nakagawasai Osamu、Takahashi Kohei、Koyama Taisei、Yamagata Ryota、Nemoto Wataru、Tan-No Koichi
- Journal Title
  
  Molecular Brain
  
  Volume: 16 Issue: 1 Pages: 52-52
- DOI
  10.1186/s13041-023-01040-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06866, KAKENHI-PROJECT-21K15351
[Journal Article] Peptides obtained by enzymatic decomposition of mackerel induce recovery from physical fatigue by enhancing the SIRT1-mediated antioxidant effect in the soleus muscle of mice2023
- Author(s)
  Nakagawasai Osamu、Takahashi Kohei、Sakuma Wakana、Nemoto Wataru、Kobayashi Ruka、Hoshi Tomohiro、Matsumoto Satoshi、Tadano Takeshi、Tan-No Koichi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 152 Issue: 1 Pages: 61-67
- DOI
  10.1016/j.jphs.2023.03.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06866, KAKENHI-PROJECT-21K15351
[Journal Article] Angiotensin-Related Peptides and Their Role in Pain Regulation2023
- Author(s)
  Nemoto Wataru、Yamagata Ryota、Nakagawasai Osamu、Tan-No Koichi
- Journal Title
  
  Biology
  
  Volume: 12 Issue: 5 Pages: 755-755
- DOI
  10.3390/biology12050755
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06168, KAKENHI-PROJECT-20K07074
[Journal Article] Low Skeletal Muscle Mass Is Associated With Perioperative Neurocognitive Disorder Due To Decreased Neurogenesis in Rats2021
- Author(s)
  Nemoto Akira、Goyagi Toru、Nemoto Wataru、Nakagawasai Osamu、Tan-No Koichi、Niiyama Yukitoshi
- Journal Title
  
  Anesthesia & Analgesia
  
  Volume: 134 Issue: 1 Pages: 194-203
- DOI
  10.1213/ane.0000000000005681
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08808, KAKENHI-PROJECT-20K07074
[Journal Article] A novel dipeptide derived from porcine liver hydrolysate induces recovery from physical fatigue in a mouse model2021
- Author(s)
  Nakagawasai Osamu、Yamada Kotaro、Sakuma Wakana、Takahashi Kohei、Odaira Takayo、Yamagata Ryota、Nemoto Wataru、Ejima Akika、Sato Kenji、Tan-No Koichi
- Journal Title
  
  Journal of Functional Foods
  
  Volume: 76 Pages: 104312-104312
- DOI
  10.1016/j.jff.2020.104312
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06687
[Journal Article] Angiotensin (1–7) Attenuates the Nociceptive Behavior Induced by Substance P and NMDA <i>via</i> Spinal MAS12021
- Author(s)
  Ryota Yamagata, Wataru Nemoto, Maho Fujita, Osamu Nakagawasai, Koichi Tan-No
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 44 Issue: 5 Pages: 742-746
- DOI
  10.1248/bpb.b20-01004
- NAID
  130008033239
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2021-05-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07074, KAKENHI-PROJECT-19K16376
[Journal Article] Antidepressant effect of BE360, a new selective estrogen receptor modulator, activated via CREB/BDNF, Bcl-2 signaling pathways in ovariectomized mice2020
- Author(s)
  Sakuma Wakana、Nakagawasai Osamu、Nemoto Wataru、Odaira Takayo、Ogawa Takumi、Ohta Kiminori、Endo Yasuyuki、Tan-No Koichi
- Journal Title
  
  Behavioural Brain Research
  
  Volume: 393 Pages: 112764-112764
- DOI
  10.1016/j.bbr.2020.112764
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06687
[Journal Article] Liver hydrolysate prevents depressive-like behavior in an animal model of colitis: Involvement of hippocampal neurogenesis via the AMPK/BDNF pathway2020
- Author(s)
  Nakagawasai Osamu、Yamada Kotaro、Takahashi Kohei、Odaira Takayo、Sakuma Wakana、Ishizawa Daisuke、Takahashi Naruya、Onuma Kentaro、Hozumi Chikako、Nemoto Wataru、Tan-No Koichi
- Journal Title
  
  Behavioural Brain Research
  
  Volume: 390 Pages: 112640-112640
- DOI
  10.1016/j.bbr.2020.112640
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06687, KAKENHI-PROJECT-19K23808
[Journal Article] Liver hydrolysate improves depressive-like behavior in olfactory bulbectomized mice: Involvement of hippocampal neurogenesis through the AMPK/BDNF/CREB pathway2020
- Author(s)
  Nakagawasai Osamu, Yamada Kotaro, Odaira Takayo, Takahashi Kohei, Nemoto Wataru, Sakuma Wakana, Wakou Miharu, Lin Jia-Rong, Tan-No Koichi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 143 Issue: 1 Pages: 52-55
- DOI
  10.1016/j.jphs.2020.01.002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23808, KAKENHI-PROJECT-18K06687
[Journal Article] Dopamine D2 receptor supersensitivity in the hypothalamus of olfactory bulbectomized mice2020
- Author(s)
  Takahashi Kohei、Nakagawasai Osamu、Nakajima Takeharu、Okubo Myu、Nishimura Yuki、Sakuma Wakana、Yamagata Ryota、Nemoto Wataru、Miyagawa Kazuya、Kurokawa Kazuhiro、Mochida-Saito Atsumi、Tsuji Minoru、Takeda Hiroshi、Tadano Takeshi、Tan-No Koichi
- Journal Title
  
  Brain Research
  
  Volume: 1746 Pages: 147015-147015
- DOI
  10.1016/j.brainres.2020.147015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07137, KAKENHI-PROJECT-20K23258, KAKENHI-PROJECT-18K06687, KAKENHI-PROJECT-19K23808
[Journal Article] Scabronine G Methyl Ester Improves Memory-Related Behavior and Enhances Hippocampal Cell Proliferation and Long-Term Potentiation via the BDNF-CREB Pathway in Olfactory Bulbectomized Mice2020
- Author(s)
  Nakagawasai Osamu、Lin Jia-Rong、Odaira Takayo、Takahashi Kohei、Nemoto Wataru、Moriguchi Shigeki、Yabuki Yasushi、Kobayakawa Yu、Fukunaga Kohji、Nakada Masahisa、Tan-No Koichi
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: 11 Pages: 583291-583291
- DOI
  10.3389/fphar.2020.583291
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06687, KAKENHI-PROJECT-18K06887, KAKENHI-PROJECT-19K23808
[Journal Article] Downregulation of spinal angiotensin converting enzyme 2 is involved in neuropathic pain associated with type 2 diabetes mellitus in mice2020
- Author(s)
  Yamagata Ryota、Nemoto Wataru、Nakagawasai Osamu、Takahashi Kohei、Tan-No Koichi
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 174 Pages: 113825-113825
- DOI
  10.1016/j.bcp.2020.113825
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16376, KAKENHI-PROJECT-17K08313, KAKENHI-PROJECT-20K07074
[Journal Article] Effect of spinal angiotensin-converting enzyme 2 activation on the formalin-induced nociceptive response in mice2020
- Author(s)
  Nemoto Wataru、Yamagata Ryota、Nakagawasai Osamu、Nakagawa Koharu、Hung Wan-Yi、Fujita Maho、Tadano Takeshi、Tan-No Koichi
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 872 Pages: 172950-172950
- DOI
  10.1016/j.ejphar.2020.172950
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16376, KAKENHI-PROJECT-17K08313, KAKENHI-PROJECT-20K07074
[Journal Article] Effect of Enterococcus faecalis 2001 on colitis and depressive-like behavior in dextran sulfate sodium-treated mice: involvement of the brain?gut axis2019
- Author(s)
  Takahashi Kohei、Nakagawasai Osamu、Nemoto Wataru、Odaira Takayo、Sakuma Wakana、Onogi Hiroshi、Nishijima Hiroaki、Furihata Ryuji、Nemoto Yukio、Iwasa Hiroyuki、Tan-No Koichi、Tadano Takeshi
- Journal Title
  
  Journal of Neuroinflammation
  
  Volume: 16 Issue: 1 Pages: 201-201
- DOI
  10.1186/s12974-019-1580-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06687
[Journal Article] Prenatal treatment with methylazoxymethanol acetate as a neurodevelopmental disruption model of schizophrenia in mice2019
- Author(s)
  Takahashi Kohei、Nakagawasai Osamu、Sakuma Wakana、Nemoto Wataru、Odaira Takayo、Lin Jia-Rong、Onogi Hiroshi、Srivastava Lalit K.、Tan-No Koichi
- Journal Title
  
  Neuropharmacology
  
  Volume: 150 Pages: 1-14
- DOI
  10.1016/j.neuropharm.2019.02.034
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06687
[Journal Article] Anti-hypersensitive effect of angiotensin (1-7) on streptozotocin-induced diabetic neuropathic pain in mice2019
- Author(s)
  Yoshiki Ogata, Wataru Nemoto, Ryota Yamagata, Osamu Nakagawasai, Shuji Shimoyama, Tomonori Furukawa, Shinya Ueno, Koichi Tan-No
- Journal Title
  
  Eur. J. Pain
  
  Volume: 23 Issue: 4 Pages: 739-749
- DOI
  10.1002/ejp.1341
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08313, KAKENHI-PROJECT-18K08846, KAKENHI-PROJECT-16K20888, KAKENHI-PROJECT-16K21311, KAKENHI-PROJECT-18K15356
[Journal Article] Mechanisms underpinning AMP-activated protein kinase-related effects on behavior and hippocampal neurogenesis in an animal model of depression2019
- Author(s)
  Odaira Takayo、Nakagawasai Osamu、Takahashi Kohei、Nemoto Wataru、Sakuma Wakana、Lin Jia-Rong、Tan-No Koichi
- Journal Title
  
  Neuropharmacology
  
  Volume: 150 Pages: 121-133
- DOI
  10.1016/j.neuropharm.2019.03.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06687
[Journal Article] Behavioral and Molecular Pharmacological Study of the Role of Angiotensin II in Spinal Pain Transmission2018
- Author(s)
  Nemoto Wataru
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 138 Issue: 10 Pages: 1235-1240
- DOI
  10.1248/yakushi.18-00124
- NAID
  130007490672
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2018-10-01
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21311
[Journal Article] Etidronate attenuates tactile allodynia by spinal ATP release inhibition in mice with partial sciatic nerve ligation2018
- Author(s)
  Yamagata Ryota、Nemoto Wataru、Nakagawasai Osamu、Hung Wan-Yi、Shima Kazuhiro、Endo Yasuo、Tan-No Koichi
- Journal Title
  
  Naunyn-Schmiedeberg's Archives of Pharmacology
  
  Volume: 392 Issue: 3 Pages: 349-357
- DOI
  10.1007/s00210-018-1593-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21311, KAKENHI-PROJECT-16K11672
[Journal Article] Effect of repeated oral administration of chondroitin sulfate on neuropathic pain induced by partial sciatic nerve ligation in mice2018
- Author(s)
  Nemoto Wataru、Yamada Kotaro、Nakagawasai Osamu、Ogata Yoshiki、Chiba Masato、Yamagata Ryota、Sakurai Hidetomo、Tan-No Koichi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 137 Issue: 4 Pages: 403-406
- DOI
  10.1016/j.jphs.2018.03.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21311
[Journal Article] Inhibitory effect of angiotensin (1-7) on angiotensin III-induced nociceptive behaviour in mice2017
- Author(s)
  Nemoto W., Yamagata R., Ogata Y., Nakagawasai O., Tadano T., Tan-No K.
- Journal Title
  
  Neuropeptides
  
  Volume: 65 Pages: 71-76
- DOI
  10.1016/j.npep.2017.05.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08313, KAKENHI-PROJECT-16K21311
[Journal Article] Chondroitin sulfate attenuates formalin-induced persistent tactile allodynia.2016
- Author(s)
  Wataru Nemoto, Kotaro Yamada, Yoshiki Ogata, Osamu Nakagawasai, Katsuhito Onodera, Hidetomo Sakurai, Koichi Tan-No
- Journal Title
  
  J. Pharmacol. Sci.
  
  Volume: 131 Issue: 4 Pages: 275-278
- DOI
  10.1016/j.jphs.2016.07.009
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K21311
[Journal Article] Involvement of spinal angiotensin II system in streptozotocin-induced diabetic neuropathic pain in mice.2016
- Author(s)
  Ogata Y, Nemoto W, Nakagawasai O, Yamagata R, Tadano T, Tan-No K.
- Journal Title
  
  Molecular Pharmacology
  
  Volume: 90 Issue: 3 Pages: 205-213
- DOI
  10.1124/mol.116.104133
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460101, KAKENHI-PROJECT-16K21311
[Journal Article] Alterations in behavioral responses to dopamine agonists in olfactory bulbectomized mice: relationship to changes in the striatal dopaminergic system2016
- Author(s)
  Kohei Takahashi, Osamu Nakagawasai, Wataru Nemoto, Takeharu Nakajima, Yuichiro Arai, Tadashi Hisamitsu, Koichi Tan-No
- Journal Title
  
  Psychopharmacology
  
  Volume: 233 Issue: 7 Pages: 1311-1322
- DOI
  10.1007/s00213-016-4224-y
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460102
[Journal Article] BE360, a new selective estrogen receptor modulator, produces antidepressant and antidementia effects through the enhancement of hippocampal cell proliferation in olfactory bulbectomized mice.2016
- Author(s)
  Osamu Nakagawasai, Wataru Nemoto, Hiroshi Onogi, Takahiro Moriya, Jia-Rong Lin, Takayo Odaira, Fukie Yaoita, Takumi Ogawa, Kiminori Ohta, Yasuyuki Endo, Koichi Tan-No
- Journal Title
  
  Behav Brain Res
  
  Volume: 297 Pages: 315-322
- DOI
  10.1016/j.bbr.2015.10.033
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460102, KAKENHI-PROJECT-26461709, KAKENHI-PROJECT-26460151
[Journal Article] Involvement of p38 MAPK activation mediated through AT1 receptors on spinal astrocytes and neurons in angiotensin II- and III-induced nociceptive behavior in mice.2015
- Author(s)
  Wataru Nemoto, Yoshiki Ogata, Osamu Nakagawasai, Fukie Yaoita, Takeshi Tadano, Koichi Tan-No
- Journal Title
  
  Neuropharmacology
  
  Volume: 99 Pages: 221-231
- DOI
  10.1016/j.neuropharm.2015.07.022
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460101
[Journal Article] The intrathecal administration of losartan, an AT1 receptor antagonist, produces an antinociceptive effect through the inhibiton of p38 MAPK phosphorylation in the mouse formalin test.2015
- Author(s)
  Wataru Nemoto, Yoshiki Ogata, Osamu Nakagawasai, Fukie Yaoita, Takeshi Tadano, Koichi Tan-No
- Journal Title
  
  Neurosci. Lett.
  
  Volume: 585 Pages: 17-22
- DOI
  10.1016/j.neulet.2014.11.018
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460101
[Journal Article] Angiotensin (1-7) prevents angiotensin II-induced nociceptive behaviour via inhibition of p38 MAPK phosphorylation mediated through spinal Mas receptors in mice.2014
- Author(s)
  Wataru Nemoto, Yoshiki Ogata, Osamu Nakagawasai, Fukie Yaoita, Takeshi Tadano, Koichi Tan-No
- Journal Title
  
  Eur. J. Pain
  
  Volume: 18 Issue: 10 Pages: 1471-1479
- DOI
  10.1002/ejp.512
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460101
[Presentation] アンジオテンシン変換酵素阻害薬とAT1受容体拮抗薬による有痛性糖尿病性神経障害の抑制：保険薬局のレセプトデータ解析による検証2024
- Author(s)
  山本卓資、岩根詩織、宮本朋佳、坪田真帆、関口富美子、榊原幹夫、根本亙、丹野孝一、川畑篤史
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-20K07074
[Presentation] 関節炎モデルマウスの痛覚過敏に対する海洋微細藻類Pavlovaの効果2024
- Author(s)
  根本亙，山田耕太郎，小林瑠夏，星友裕，中原剣，金本昭彦，中川西修，丹野孝一
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K06168
[Presentation] 脊髄内ADAM17は2型糖尿病に伴う神経障害性疼痛に関与する2023
- Author(s)
  根本　亙，山縣涼太，中川西修，丹野孝一
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-23K06168
[Presentation] レニン・アンギオテンシン系阻害薬は糖尿病性末梢神経障害の発症を抑制する：3病院での後ろ向きコホート研究と基礎研究での検証2023
- Author(s)
  岩根詩織、根本亙、宮本朋佳、林友典、田中雅幸、打谷和記、小泉祐一、平田敦士、坪田真帆、関口富美子、丹野孝一、川畑篤史
- Organizer
  第33回日本医療薬学会
- Data Source
  KAKENHI-PROJECT-20K07074
[Presentation] Analgesic mechanisms for inflammatory pain by spinal angiotensin (1-7)-generating system2023
- Author(s)
  Wataru Nemoto, Ryota Yamagata, Osamu Nakagawasai, Koharu Nakagawa, Wan-Yi Hung, Maho Fujita, Koichi Tan-No
- Organizer
  34th CINP World Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06168
[Presentation] 脊髄内ADAM17は2型糖尿病に伴う神経障害性疼痛に関与する2023
- Author(s)
  根本亙、山縣涼太、中川西修、丹野孝一
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K07074
[Presentation] Analgesic mechanisms for inflammatory pain by spinal angiotensin (1-7)-generating system2023
- Author(s)
  Nemoto Wataru、Yamagata Ryota、Nakagawasai Osamu、Nakagawa Koharu、Hung Wan-Yi、Fujita Maho、Tan-No Koichi
- Organizer
  34th CINP World Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07074
[Presentation] 脳内アンジオテンシン変換酵素２活性化による抗うつ作用とその機序2023
- Author(s)
  中川西修，髙橋浩平，小山泰成，山縣涼太，根本亙，丹野孝一
- Organizer
  第25回活性アミンに関するワークショップ
- Data Source
  KAKENHI-PROJECT-22K06866
[Presentation] 高血圧を合併する糖尿病患者における末梢神経障害の発症に対するアンギオテンシン変換酵素阻害薬または受容体拮抗薬の抑制効果：3病院での臨床知見と基礎研究による検証2023
- Author(s)
  冨田詩織，根本亙，宮本朋佳，林友典，田中雅幸，打谷和記，村中達也，小泉祐一，平田敦士，坪田真帆，関口富美子，丹野孝一，川畑篤史
- Organizer
  日本薬学会
- Data Source
  KAKENHI-PROJECT-20K07074
[Presentation] 脊髄内ADAM17のアップレギュレーションが2型糖尿病に伴う神経障害性疼痛に関与する2022
- Author(s)
  根本　亙，山縣　涼太，中川西　修，丹野　孝一
- Organizer
  NEURO2022
- Data Source
  KAKENHI-PROJECT-19K16376
[Presentation] アンジオテンシン変換酵素阻害薬の抗うつ作用メカニズムについて2022
- Author(s)
  中川西修，小平貴代，小野涼太郎，髙橋浩平，根本　亙，若生美春，小野木弘志，只野　武，丹野孝一
- Organizer
  第24回活性アミンに関するワークショップ
- Data Source
  KAKENHI-PROJECT-22K06866
[Presentation] Upregulation of spinal ADAM17 contributes to neuropathic pain associated with type 2 diabetes mellitus in mice.2022
- Author(s)
  Wataru Nemoto, Ryota Yamagata, Osamu Nakagawasai, Koichi Tan-No
- Organizer
  NEURO 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07074
[Presentation] アンギオテンシン変換酵素阻害薬とアンギオテンシンII受容体拮抗薬は糖尿病性末梢神経障害の発症を抑制する：臨床・基礎融合研究によるエビデンス2022
- Author(s)
  冨田詩織，宮本朋佳，田中雅幸，打谷和記，小泉祐一，村中達也，根本　亙，丹野孝一，坪田真帆，関口富美子，川畑篤史
- Organizer
  生体機能と創薬シンポジウム2022
- Data Source
  KAKENHI-PROJECT-20K07074
[Presentation] 脊髄ACE2による疼痛制御機構の解明2022
- Author(s)
  根本　亙
- Organizer
  生体機能と創薬シンポジウム2022
- Invited
- Data Source
  KAKENHI-PROJECT-19K16376
[Presentation] 嗅球摘出マウスにおけるcaptoprilの海馬アンジオテンシン (1-7) / MAS1経路を介した抗うつ様効果2021
- Author(s)
  若生美春、中川西修、小山泰成、小平貴代、佐久間若菜、山縣涼太、根本亙、丹野孝一
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K06687
[Presentation] 糖尿病性神経障害性疼痛の解明：アンジオテンシン (1-7) 系からの検討2020
- Author(s)
  根本　亙、山縣涼太、小潟佳輝、中川西　修、八百板富紀枝、丹野　孝一
- Organizer
  第71回日本薬理学会北部会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07074
[Presentation] 糖尿病性神経障害性疼痛の解明：アンジオテンシン (1-7) 系からの検討2020
- Author(s)
  根本亙、山縣涼太、小潟佳輝、中川西修、八百板富紀枝、丹野孝一
- Organizer
  第71回日本薬理学会北部会
- Invited
- Data Source
  KAKENHI-PROJECT-19K16376
[Presentation] 糖尿病性神経障害性疼痛における脊髄内 ADAM17 の関与2020
- Author(s)
  山縣涼太、根本　亙、中川西　修、丹野孝一
- Organizer
  第59回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-19K16376
[Presentation] 糖尿病性神経障害性疼痛における脊髄内 ADAM17 の関与2020
- Author(s)
  山縣涼太、根本　亙、中川西　修、丹野孝一
- Organizer
  第59回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-20K07074
[Presentation] 脊髄Angiotensin 系の不均衡が糖尿病性神経障害性疼痛に寄与する2019
- Author(s)
  山縣涼太、根本亙、小潟佳輝、中川西修、八百板富紀枝、丹野孝一
- Organizer
  平成31年度東北医科薬科大学創薬研究センターシンポジウム
- Data Source
  KAKENHI-PROJECT-17K08313
[Presentation] 糖尿病性神経障害性疼痛における脊髄アンジオテンシン系の関与の解明―新たな治療戦略を目指して―2019
- Author(s)
  丹野孝一、小潟佳輝、山縣涼太、根本　亙
- Organizer
  生体機能と創薬シンポジウム2019
- Data Source
  KAKENHI-PROJECT-17K08313
[Presentation] Behavioral, cytoarchitectural, and neurochemical changes in the offspring of methylazoxymethanol treated in mice2019
- Author(s)
  Osamu Nakagawasai, Kohei Takahashi, Wakana Sakuma, Wataru Nemoto, Takayo Odaira, Lin Jia-Rong, Hiroshi Onogi, Lalit K Srivastava, Koichi Tan-No
- Organizer
  2019 International Society for Neurochemistry Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06687
[Presentation] 絞扼性神経損傷マウスにおけるdiminazene aceturateの抗痛覚過敏作用2019
- Author(s)
  Hung Wan-Yi、根本亙、中川西修、丹野孝一
- Organizer
  第70回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-19K16376
[Presentation] 絞扼性神経損傷マウスにおけるdiminazene aceturateの抗痛覚過敏作用2019
- Author(s)
  Hung WY、根本　亙、中川西修、丹野孝一
- Organizer
  第70回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-17K08313
[Presentation] 脊髄 Angiotensin 系の不均衡が糖尿病性神経障害性疼痛に寄与する2019
- Author(s)
  山縣涼太、根本亙、小潟佳輝、中川西修、八百板富紀枝、丹野孝一
- Organizer
  令和元年度東北医科薬科大学創薬研究センターシンポジウム
- Data Source
  KAKENHI-PROJECT-19K16376
[Presentation] 坐骨神経部分結紮マウスにおけるエチドロン酸の抗痛覚過敏作用について2019
- Author(s)
  根本亙，山縣涼太，中川西修，Hung Wan-Yi，島和弘，遠藤康男，丹野孝一
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-16K21311
[Presentation] Captoprilの海馬Angiotensin(1-7)/Mas受容体系の活性化を介した抗うつ効果2019
- Author(s)
  小平　貴代，中川西　修，小野涼太郎，根本　亙，髙橋　浩平，佐久間若菜，丹野　孝一
- Organizer
  第58回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-18K06687
[Presentation] 海馬AMPKシグナリングの活性化は嗅球摘出マウスのうつ様行動を改善する2019
- Author(s)
  小平貴代，中川西修，根本亙，髙橋浩平，佐久間若菜，丹野孝一
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K06687
[Presentation] レプチン欠損マウスの神経障害性疼痛に対するアンジオテンシン (1-7) の効果2019
- Author(s)
  山縣涼太、根本亙、中川西修、丹野孝一
- Organizer
  第70回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-19K16376
[Presentation] レプチン欠損マウスの神経障害性疼痛に対するアンジオテンシン (1-7) の効果2019
- Author(s)
  山縣涼太、根本　亙、中川西修、丹野孝一
- Organizer
  第70回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-17K08313
[Presentation] 2型糖尿病マウスの神経障害性疼痛における脊髄アンジオテンシン系の関与2019
- Author(s)
  根本亙、山縣涼太、丹野孝一
- Organizer
  生体機能と創薬ポジウム2019
- Invited
- Data Source
  KAKENHI-PROJECT-19K16376
[Presentation] レプチン欠損マウスの接触性痛覚過敏に対するアンジオテンシン (1-7) の抑制効果2019
- Author(s)
  山縣涼太、根本　亙、中川西修、丹野孝一
- Organizer
  第58回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-17K08313
[Presentation] Angiotensin変換酵素阻害薬Captoprilの抗うつ作用はAngiotensin (1-7)/Mas受容体を介する2019
- Author(s)
  小平　貴代，中川西　修，小野涼太郎，根本　亙，髙橋　浩平，佐久間若菜，荒井裕一朗，只野　武，丹野　孝一
- Organizer
  第23回活性アミンに関するワークショップ
- Data Source
  KAKENHI-PROJECT-18K06687
[Presentation] Antinociceptive effect of diminazene aceturate, an angiotensin-converting enzyme 2 activator, in the mouse formalin test2019
- Author(s)
  Nemoto W, Yamagata R, Nakagawasai O, Michimata S, Nakagawa K, Tan-No K
- Organizer
  2019 International Society for Neurochemistry Meeting
- Data Source
  KAKENHI-PROJECT-17K08313
[Presentation] ストレプトゾトシン誘発性糖尿病性神経障害性疼痛に対するAngiotensin (1-7) の抑制効果2019
- Author(s)
  山縣涼太，根本亙，小潟佳輝，中川西修，丹野孝一
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16K21311
[Presentation] ストレプトゾトシン誘発性糖尿病性神経障害性疼痛に対するAngiotensin (1-7) の抑制効果2019
- Author(s)
  山縣涼太，根本亙，小潟佳輝，中川西修，丹野孝一
- Organizer
  日本薬学会第139年会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08313
[Presentation] 糖尿病性神経障害性疼痛における脊髄アンジオテンシン系の関与の解明―新たな治療戦略を目指して―2019
- Author(s)
  丹野孝一、小潟佳輝、山縣涼太、根本亙
- Organizer
  生体機能と創薬ポジウム2019
- Invited
- Data Source
  KAKENHI-PROJECT-19K16376
[Presentation] p-Hydroxyamphetamine causes prepulse inhibition disruptions in mice: Contribution of catecholamine and serotonin neurotransmission2019
- Author(s)
  Hiroshi Onogi, Osamu Nakagawasai, Wataru Nemoto, Satoru Mitazaki, Koichi Tan-No, Takeshi Tadano
- Organizer
  2019 International Society for Neurochemistry Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06687
[Presentation] レプチン欠損マウスの接触性痛覚過敏に対するアンジオテンシン (1-7) の抑制効果2019
- Author(s)
  山縣涼太、根本亙、中川西修、丹野孝一
- Organizer
  第58回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-19K16376
[Presentation] Antinociceptive effect of diminazene aceturate, an angiotensin-converting enzyme 2 activator, in the mouse formalin test2019
- Author(s)
  Wataru Nemoto, Ryota Yamagata, Osamu Nakagawasai, Shota Michimata, Koharu Nakagawa, Koichi Tan-No
- Organizer
  2019 International Society for Neurochemistry Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16376
[Presentation] 2型糖尿病マウスの神経障害性疼痛における脊髄アンジオテンシン系の関与2019
- Author(s)
  根本　亙、山縣涼太、丹野孝一
- Organizer
  生体機能と創薬シンポジウム2019
- Data Source
  KAKENHI-PROJECT-17K08313
[Presentation] Inhibitory effect of repeated oral administration of chondroitin sulfate on the formalin-induced tactile allodynia in mice2018
- Author(s)
  Wataru Nemoto, Kotaro Yamada, Osamu Nakagawasai, Yoshiki Ogata, Hidetomo Sakurai, Koichi Tan-No
- Organizer
  18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21311
[Presentation] メマンチンの海馬ドパミン神経系を介した抗うつ効果2018
- Author(s)
  髙橋　浩平，中川西　修，根本　亙，小平　貴代，佐久間若菜，荒井裕一朗，只野　武，丹野　孝一
- Organizer
  第22回活性アミンに関するワークショップ
- Data Source
  KAKENHI-PROJECT-18K06687
[Presentation] Angiotensin (1-7) prevents streptozotocin-induced diabetic neuropathic pain in mice2018
- Author(s)
  Wataru Nemoto, Yoshiki Ogata, Ryota Yamagata, Osamu Nakagawasai, Koichi Tan-No
- Organizer
  31th European College of Neuropsychopharmacology Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21311
[Presentation] Anti-allodynic effect of angiotensin (1-7) on streptozotocin-induced diabetic neuropathic pain2018
- Author(s)
  Ryota Yamagata, Wataru Nemoto, Yoshiki Ogata, Osamu Nakagawasai, Koichi Tan-No
- Organizer
  18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08313
[Presentation] 2型糖尿病モデルマウスにおけるアンジオテンシン（1-7）の抗痛覚過敏作用2018
- Author(s)
  山縣　涼太，根本　亙，中川西　修，丹野　孝一
- Organizer
  第69回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-17K08313
[Presentation] Angiotensin (1-7) prevents streptozotocin-induced diabetic neuropathic pain in mice2018
- Author(s)
  Wataru Nemoto, Yoshiki Ogata, Ryota Yamagata, Osamu Nakagawasai, Koichi Tan-No
- Organizer
  31th European College of Neuropsychopharmacology Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08313
[Presentation] 2型糖尿病モデルマウスにおけるアンジオテンシン（1-7）の抗痛覚過敏作用2018
- Author(s)
  山縣　涼太，根本　亙，中川西　修，丹野　孝一
- Organizer
  第69回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-16K21311
[Presentation] Memantine produces antidepressant effect through the enhancement of hippocampal neurogenesis in olfactory bulbectomized mice2018
- Author(s)
  Osamu Nakagawasai, Kohei Takahashi, Wataru Nemoto, Takayo Odaira, Wakana Sakuma, Yuichiro Arai, Takeshi Tadano, Koichi Tan-No
- Organizer
  31th European College of Neuropsychopharmacology Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06687
[Presentation] Anti-allodynic effect of angiotensin (1-7) on streptozotocin-induced diabetic neuropathic pain2018
- Author(s)
  Ryota Yamagata, Wataru Nemoto, Yoshiki Ogata, Osamu Nakagawasai, Koichi Tan-No
- Organizer
  18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21311
[Presentation] 脊髄疼痛伝達機構におけるAngiotensin IIの役割に関する行動および分子薬理学的研究2017
- Author(s)
  根本亙
- Organizer
  第39回東北薬学セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-16K21311
[Presentation] 糖尿病性神経障害性疼痛に対するアンジオテンシン (1-7) の抑制効果2017
- Author(s)
  山縣涼太，根本　亙，小潟佳輝，中川西　修，八百板富紀枝，丹野孝一
- Organizer
  平成29年度東北医科薬科大学創薬研究センターシンポジウム
- Data Source
  KAKENHI-PROJECT-17K08313
[Presentation] アンジオテンシン (1-7) は糖尿病性神経障害性疼痛を抑制する2017
- Author(s)
  小潟佳輝、根本亙、中川西修、丹野孝一
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール、長崎新聞文化ホールアストピア (長崎県・長崎市)
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16K21311
[Presentation] 嗅球摘出マウスの精神機能障害に対する肝臓水解物の効果：海馬AMP活性化プロテインキナーゼの関与について2017
- Author(s)
  中川西修，山田耕太郎，小平貴代，佐久間若菜，根本亙，櫻井英知，丹野孝一
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-26460102
[Presentation] 1型糖尿病モデルマウスにおける神経障害性疼痛に対するアンジオテンシン (1-7) の抑制効果2017
- Author(s)
  山縣涼太，根本　亙，小潟佳輝，中川西　修，丹野孝一
- Organizer
  生体機能と創薬シンポジウム2017
- Data Source
  KAKENHI-PROJECT-17K08313
[Presentation] 糖尿病性神経障害性疼痛に対するアンジオテンシン (1-7) の抑制効果2017
- Author(s)
  山縣涼太、根本亙、小潟佳輝、中川西修、八百板富紀枝、丹野孝一
- Organizer
  平成29年度東北医科薬科大学創薬研究センターシンポジウム
- Data Source
  KAKENHI-PROJECT-16K21311
[Presentation] ストレプトゾトシン誘発性1型糖尿病マウスにおけるアンジオテンシン (1-7) の抗アロディニア作用2017
- Author(s)
  山縣涼太、根本亙、小潟佳輝、中川西修、丹野孝一
- Organizer
  第68回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-16K21311
[Presentation] ストレプトゾトシン誘発性1型糖尿病マウスにおけるアンジオテンシン (1-7) の抗アロディニア作用2017
- Author(s)
  山縣涼太，根本　亙，小潟佳輝，中川西　修，丹野孝一
- Organizer
  第68回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-17K08313
[Presentation] 1型糖尿病モデルマウスにおける神経障害性疼痛に対するアンジオテンシン (1-7) の抑制効果2017
- Author(s)
  山縣涼太、根本亙、小潟佳輝、中川西修、丹野孝一
- Organizer
  生体機能と創薬シンポジウム2017
- Data Source
  KAKENHI-PROJECT-16K21311
[Presentation] 脊髄Angiotensin系は糖尿病性神経障害性疼痛の治療標的になり得るか？2017
- Author(s)
  根本亙、小潟佳輝、山縣涼太、中川西修、八百板富紀枝、丹野孝一
- Organizer
  平成29年度東北医科薬科大学創薬研究センターシンポジウム
- Data Source
  KAKENHI-PROJECT-16K21311
[Presentation] アンジオテンシン (1-7) は糖尿病性神経障害性疼痛を抑制する2017
- Author(s)
  小潟佳輝、根本亙、中川西修、丹野孝一
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール（長崎県、長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-26460101
[Presentation] 嗅球摘出マウスの認知機能障害に対するアリピプラゾールの効果2017
- Author(s)
  髙橋浩平，中川西修，根本亙，小平貴代，荒井裕一朗，久光正，丹野孝一
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-26460102
[Presentation] 嗅球摘出マウスのうつ様行動に対するメマンチンの効果2017
- Author(s)
  髙橋浩平，中川西修，根本亙，小平貴代，丹野孝一
- Organizer
  日本薬学会第137年会
- Place of Presentation
  東北大学川内キャンパス(宮城県仙台市）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-26460102
[Presentation] 脊髄Angiotensin系は糖尿病性神経障害性疼痛の治療標的になり得るか？2017
- Author(s)
  根本　亙，小潟佳輝，山縣涼太，中川西　修，八百板富紀枝，丹野孝一
- Organizer
  平成29年度東北医科薬科大学創薬研究センターシンポジウム
- Data Source
  KAKENHI-PROJECT-17K08313
[Presentation] アンジオテンシンⅢ誘発性侵害刺激行動に対するアンジオテンシン (1-7) の抑制作用について2017
- Author(s)
  根本亙、中川西修、丹野孝一
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール（長崎県、長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-26460101
[Presentation] アンジオテンシンIII誘発性侵害刺激行動に対するアンジオテンシン (1-7) の抑制作用について2017
- Author(s)
  根本亙、中川西修、丹野孝一
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール、長崎新聞文化ホールアストピア (長崎県・長崎市)
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16K21311
[Presentation] 脊髄疼痛伝達機構におけるAngiotensin IIの役割に関する行動および分子薬理学的研究2017
- Author(s)
  根本　亙
- Organizer
  第39回東北薬学セミナー
- Data Source
  KAKENHI-PROJECT-17K08313
[Presentation] 嗅球摘出マウスのうつ様行動に対するAngiotensin変換酵素阻害薬Captoprilの効果2017
- Author(s)
  小野涼太郎，中川西修，小平貴代，佐久間若菜，根本亙，丹野孝一
- Organizer
  第26回神経行動薬理若手研究者の集い
- Place of Presentation
  福岡大学メディカルホール（福岡県福岡市）
- Data Source
  KAKENHI-PROJECT-26460102
[Presentation] 脊髄疼痛伝達機構におけるアンジオテンシンⅡの役割2016
- Author(s)
  根本亙、小潟佳輝、丹野孝一
- Organizer
  生体機能と創薬シンポジウム2016
- Place of Presentation
  東北大学川内キャンパス（宮城県、仙台市）
- Year and Date
  2016-08-25
- Invited
- Data Source
  KAKENHI-PROJECT-26460101
[Presentation] 1型糖尿病モデルマウスの機械的アロディニアにおける脊髄内アンジオテンシンⅡ系の関与2016
- Author(s)
  山縣涼太、根本亙、小潟佳輝、中川西修、八百板富紀枝、丹野孝一
- Organizer
  生体機能と創薬シンポジウム2016
- Place of Presentation
  東北大学川内キャンパス（宮城県、仙台市）
- Year and Date
  2016-08-25
- Data Source
  KAKENHI-PROJECT-26460101
[Presentation] 更年期障害モデルマウスのうつ状態に対する新規選択的エストロゲン受容体モジュレターBE360の効果2016
- Author(s)
  佐久間若菜，中川西修，根本亙，八百板富紀枝，小川卓巳，太田公規，遠藤泰之，丹野孝一
- Organizer
  生体機能と創薬シンポジウム2016
- Place of Presentation
  東北大学川内キャンパス（宮城県仙台市）
- Year and Date
  2016-08-25
- Data Source
  KAKENHI-PROJECT-26460102
[Presentation] 脊髄疼痛伝達機構におけるアンジオテンシンIIの役割2016
- Author(s)
  根本亙、小潟佳輝、丹野孝一
- Organizer
  生体機能と創薬シンポジウム2016
- Place of Presentation
  東北大学川内北キャンパス (宮城県・仙台市)
- Year and Date
  2016-08-25
- Invited
- Data Source
  KAKENHI-PROJECT-16K21311
[Presentation] スカブロニンG-メチルエステルの認知障害改善作用とその機序について2016
- Author(s)
  小平貴代，中川西修，林嘉蓉，根本亙，佐久間若菜，小原祐太郎，小早川優，中田雅久，丹野孝一
- Organizer
  次世代を担う創薬・医療薬理シンポジウム2016
- Place of Presentation
  東北大学川内キャンパス（宮城県仙台市）
- Data Source
  KAKENHI-PROJECT-26460102
[Presentation] 1型糖尿病モデルマウスの機械的アロディニアにおける脊髄内アンジオテンシンII系の関与2016
- Author(s)
  山縣涼太、根本亙、小潟佳輝、中川西修、八百板富紀枝、丹野孝一
- Organizer
  生体機能と創薬シンポジウム2016
- Place of Presentation
  東北大学川内北キャンパス (宮城県・仙台市)
- Year and Date
  2016-08-25
- Data Source
  KAKENHI-PROJECT-16K21311
[Presentation] 嗅球摘出マウスにおける線条体Dopamine受容体機能変化とそれに及ぼす抗うつ薬の影響2016
- Author(s)
  髙橋浩平，中川西修，根本亙，菊地恵理，佐久間若菜，小平貴代，丹野孝一
- Organizer
  第67回日本薬理学会北部会
- Place of Presentation
  北海道大学学術交流会館（北海道札幌市）
- Data Source
  KAKENHI-PROJECT-26460102
[Presentation] うつ病モデルマウスの脳内ドパミン神経機能変化について2016
- Author(s)
  中川西修，髙橋浩平，根本亙，菊地恵理，佐久間若菜，小平貴代，八百板富紀枝，荒井裕一朗，只野武，丹野孝一
- Organizer
  第20回活性アミンに関するワークショップ
- Place of Presentation
  ホテルマークワンつくば研究学園（茨城県つくば市）
- Data Source
  KAKENHI-PROJECT-26460102
[Presentation] The effects of liver hydrolysate on physical fatigue and sickness behavior2015
- Author(s)
  Kotaro Yamada, Osamu Nakagawasai, Wataru Nemoto, Hidetomo Sakurai, Koichi Tan-No
- Organizer
  12th Asian Congress of Nutrition
- Place of Presentation
  パシフィコ横浜 (神奈川県横浜市)
- Year and Date
  2015-05-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460102
[Presentation] 脊髄疼痛伝達機構におけるアンジオテンシンIIIの役割2015
- Author(s)
  根本　亙、小潟佳輝、中川西　修、八百板　富紀枝、只野　武、丹野孝一
- Organizer
  第66回日本薬理学会北部会
- Place of Presentation
  富山国際会議場（富山県富山市）
- Year and Date
  2015-09-18
- Data Source
  KAKENHI-PROJECT-26460101
[Presentation] Scabronine G-methylester attenuates hippocampal neurogenesis impairment and the memory deficits induced by olfactory bulbectomy2015
- Author(s)
  Jia Rong Lin, Osamu Nakagawasai, Wataru Nemoto, Yutaro Obara, Fukie Yaoita, Yu Kobayakawa, Masahisa Nakada, Koichi Tan-No
- Organizer
  第24回神経行動薬理若手研究者の集い
- Place of Presentation
  名古屋、愛知県
- Year and Date
  2015-03-17
- Data Source
  KAKENHI-PROJECT-26460102
[Presentation] 有痛性糖尿病性神経障害における脊髄アンジオテンシンIIの関与2015
- Author(s)
  小潟佳輝、根本　亙、中川西　修、八百板　富紀枝、只野　武、丹野孝一
- Organizer
  生体機能と創薬シンポジウム2015
- Place of Presentation
  日本大学薬学部（千葉県船橋市）
- Year and Date
  2015-08-27
- Data Source
  KAKENHI-PROJECT-26460101
[Presentation] 有痛性糖尿病性ニューロパチーにおける脊髄アンジオテンシン系の関与2015
- Author(s)
  小潟佳輝、根本　亙、中川西　修、八百板　富紀枝、只野　武、丹野孝一
- Organizer
  第66回日本薬理学会北部会
- Place of Presentation
  富山国際会議場（富山県富山市）
- Year and Date
  2015-09-18
- Data Source
  KAKENHI-PROJECT-26460101
[Presentation] 糖尿病誘発性アロディニアに対する脊髄アンジオテンシン系の関与2015
- Author(s)
  小潟佳輝、根本亙、中川西修、八百板富紀枝、只野武、丹野孝一
- Organizer
  第24回神経行動薬理若手研究者の集い
- Place of Presentation
  名城大学名駅サテライト(愛知県、名古屋市）
- Year and Date
  2015-03-17
- Data Source
  KAKENHI-PROJECT-26460101
[Presentation] NMDA受容体遮断薬MK-801誘発性記憶障害に対する緑茶成分テアニンの改善効果2014
- Author(s)
  宮昂平、中川西修、根本亙、八百板富紀枝、丹野孝一
- Organizer
  宮城薬剤師学術フォーラム2014
- Place of Presentation
  仙台、宮城県
- Year and Date
  2014-11-30
- Data Source
  KAKENHI-PROJECT-26460102
[Presentation] 胎生期メチルアゾキシメタノール処理マウスが神経発達障害仮説に基づいた統合失調症モデルに成り得るか？2014
- Author(s)
  中川西修、手塚大介、根本亙、八百板富紀枝、荒井裕一朗、只野武、丹野孝一
- Organizer
  第18回活性アミンに関するワークショップ
- Place of Presentation
  高松、香川県
- Year and Date
  2014-08-30
- Data Source
  KAKENHI-PROJECT-26460102
[Presentation] ロサルタンの抗侵害刺激作用について2014
- Author(s)
  根本亙、小潟佳輝、中川西修、八百板富紀枝、只野武、丹野孝一
- Organizer
  第126回日本薬理学会近畿部会
- Place of Presentation
  和歌山県JAビル（和歌山県、和歌山市）
- Year and Date
  2014-10-24
- Data Source
  KAKENHI-PROJECT-26460101
[Presentation] Angiotensin II type 1 receptor-mediated increase in spinal p38 MAPK phosphorylation leads to the induction of nociceptive behavior in mice
- Author(s)
  Osamu Nakagawasai, Wataru Nemoto, Yoshiki Ogata, Fukie Yaoita, Takeshi Tadano, Koichi Tan-No
- Organizer
  International Narcotics Research Conference 2014
- Place of Presentation
  Montreal, Canada
- Year and Date
  2014-07-13 – 2014-07-18
- Data Source
  KAKENHI-PROJECT-26460102
[Presentation] Role of the spinal angiotensin system in nociceptive transmission.
- Author(s)
  Wataru Nemoto, Osamu Nakagawasai, Fukie Yaoita, Koichi Tan-No
- Organizer
  生体機能と創薬シンポジウム2014
- Place of Presentation
  近畿大学東大阪キャンパス（大阪府、東大阪市）
- Year and Date
  2014-08-28 – 2014-08-29
- Invited
- Data Source
  KAKENHI-PROJECT-26460101
[Presentation] 疼痛伝達機構における脊髄アンジオテンシン系の役割
- Author(s)
  根本亙、小潟佳輝、中川西修、八百板富紀枝、只野武、丹野孝一
- Organizer
  第16回応用薬理シンポジウム
- Place of Presentation
  ホテル松島大観荘(宮城県、宮城郡松島町）
- Year and Date
  2014-12-05 – 2014-12-06
- Data Source
  KAKENHI-PROJECT-26460101
[Presentation] Antagonistic effect of angiotensin (1-7) on angiotensin II-induced nociceptive behavior in mice.
- Author(s)
  Wataru Nemoto, Yoshiki Ogata, Osamu Nakagawasai, Fukie Yaoita, Takeshi Tadanoa, Koichi Tan-No
- Organizer
  International Narcotics Research Conference 2014
- Place of Presentation
  Montreal (Canada)
- Year and Date
  2014-07-13 – 2014-07-18
- Data Source
  KAKENHI-PROJECT-26460101
[Presentation] Angiotensin II type 1 receptor-mediated increase in spinal p38 MAPK phosphorylation leads to the induction of nociceptive behavior in mice.
- Author(s)
  Osamu Nakagawasai, Wataru Nemoto, Yoshiki Ogata, Fukie Yaoita, Takeshi Tadanoa, Koichi Tan-No
- Organizer
  International Narcotics Research Conference 2014
- Place of Presentation
  Montreal (Canada)
- Year and Date
  2014-07-13 – 2014-07-18
- Data Source
  KAKENHI-PROJECT-26460101
[Presentation] ストレプトゾトシン誘発糖尿病性神経障害性疼痛における脊髄アンジオテンシン系の関与
- Author(s)
  小潟佳輝、根本亙、中川西修、八百板富紀枝、只野武、丹野孝一
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場(愛知県、名古屋市）
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-26460101
[Presentation] メチルアゾキシメタノールを用いた統合失調症モデルマウスの作製
- Author(s)
  中川西修、手塚大介、根本亙、八百板富紀枝、只野武、丹野孝一
- Organizer
  第16回応用薬理シンポジウム
- Place of Presentation
  松島、宮城県
- Year and Date
  2014-12-05 – 2014-12-06
- Invited
- Data Source
  KAKENHI-PROJECT-26460102
[Presentation] ロサルタンの脊髄クモ膜下腔内投与による抗侵害刺激作用について
- Author(s)
  根本亙、小潟佳輝、中川西修、八百板富紀枝、只野武、丹野孝一
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場(愛知県、名古屋市）
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-26460101
[Presentation] 糖尿病性神経障害性疼痛における脊髄アンジオテンシンIIの関与
- Author(s)
  小潟佳輝、根本亙、中川西修、八百板富紀枝、只野武、丹野孝一
- Organizer
  第65回日本薬理学会北部会
- Place of Presentation
  コラッセふくしま（福島県、福島市）
- Year and Date
  2014-09-26 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26460101
[Presentation] 1型糖尿病モデルマウスの神経障害性疼痛に対する脊髄アンジオテンシン系の関与
- Author(s)
  根本亙、小潟佳輝、中川西修、八百板富紀枝、只野武、丹野孝一
- Organizer
  日本薬学会第135年会
- Place of Presentation
  デザイン・クリエイティブセンター神戸(兵庫県、神戸市）
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26460101

1. TAN-NO Koichi (20207260)

# of Collaborated Projects: 6 results

# of Collaborated Products: 68 results
2. NAKAGAWASAI Osamu (50296018)

# of Collaborated Projects: 6 results

# of Collaborated Products: 74 results
3. 小野木弘志 (50610200)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
4. 大河原雄一 (40333801)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. OBARA Yutarou (40400270)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 高橋浩平 (90846411)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. TSUJI Minoru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. MIYAGAWA Kazuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 合谷木徹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 黒川和宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NEMOTO Wataru 根本 亙

Research Projects

Research Products

Co-Researchers

Could the spinal angiotensin system be a novel therapeutic target for intractable pain?

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脊髄内TNF-α変換酵素による細胞外領域シェディングを介した疼痛制御機構Principal Investigator

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Functional analysis of angiotensin-converting enzyme 2 in the brain and development of novel therapeutic agents for depression

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Elucidation of neuropathic pain associated with type 2 diabetes mellitus: Involvement of spinal angiotensin system and development of the novel therapeutic agents

Principal Investigator

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Research Institution

Role of angiotensin-converting enzyme 2 in neuropathic pain and development of novel therapeutic agentsPrincipal Investigator

Principal Investigator

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Role of brain angiotensin system on animal model of depression

Principal Investigator

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Elucidation of the mechanism underlying diabetic neuropathic pain and development of its new therapy: Examination from the viewpoint of spinal angiotensin system

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The elucidation of the involvement of spinal angiotensin II system in intractable pain and the development of new therapyPrincipal Investigator

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Elucidation of the role of spinal angiotensin system in chronic pain: Aim at developing the new therapy

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Development of hippocampal neurogenesis-promoting drugs as a target for the treatment and prevention of psychiatric disorders

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[Journal Article] Clinical and preclinical evidence that angiotensin-converting enzyme inhibitors and angiotensin receptor blockers prevent diabetic peripheral neuropathy2024

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[Journal Article] Effect of Globin Digests on Physical Fatigue in Mice2023

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[Journal Article] Activation of angiotensin-converting enzyme 2 produces an antidepressant-like effect via MAS receptors in mice2023

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NEMOTO Wataru 根本亙