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Natsuizaka Mitsuteru  夏井坂 光輝

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… Alternative Names

夏井坂 光輝  ナツイザカ ミツテル

NATSUIZAKA Mitsuteru  夏井坂 光輝

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Researcher Number 80642446
Other IDs
Affiliation (Current) 2025: 北海道大学, 医学研究院, 客員研究員
Affiliation (based on the past Project Information) *help 2022 – 2023: 北海道大学, 医学研究院, 客員研究員
2017 – 2020: 北海道大学, 医学研究院, 客員研究員
2016: 北海道大学, 医学研究科, 客員研究員
2015: 北海道大学, 医学(系)研究科(研究院), 客員研究員
2014: 北海道大学, 北海道大学病院, 助教
2013 – 2014: 北海道大学, 大学病院, 助教
Review Section/Research Field
Principal Investigator
Basic Section 53010:Gastroenterology-related / Gastroenterology
Except Principal Investigator
Gastroenterology
Keywords
Principal Investigator
癌幹細胞 / 食道扁平上皮癌 / FGF / MEK阻害剤 / CD44 / 免疫チェックポイント阻害剤 / オーガノイド / 治療抵抗性 / EGFR阻害剤 / FGFR阻害剤 … More / EMT / EMT / CD44 / 上皮間葉転換 … More
Except Principal Investigator
三次元培養 / CD44 / 3次元培養 / CD44 / 食道扁平上皮癌 / EGFR阻害剤 / 癌幹細胞ニッチ / 癌幹細胞 / 遺伝子網羅的解析 / 膵癌 / EUS-FNA / 遺伝子変異解析 Less
  • Research Projects

    (6 results)
  • Research Products

    (24 results)
  • Co-Researchers

    (13 People)
  •  食道扁平上皮癌がん幹細胞における免疫逃避機構の解明Principal Investigator

    • Principal Investigator
      夏井坂 光輝
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Hokkaido University
  •  A novel treatment targeting cancer stem-like cells in esophageal squamous cell carcinomaPrincipal Investigator

    • Principal Investigator
      Natsuizaka Mitsuteru
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Hokkaido University
  •  FGFR inhibitors eliminate cancer stem-like cells in esophageal squamous cell carcinomaPrincipal Investigator

    • Principal Investigator
      Natsuizaka Mitsuteru
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Hokkaido University
  •  Analysis of cancer stem cell niche by using esophageal orgnotypic 3D culture system

    • Principal Investigator
      Yoshito Komatsu
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Hokkaido University
  •  Development of a novel therapy targeting cancer stem-ike cells in Esophageal Cell CarcinomaPrincipal Investigator

    • Principal Investigator
      NATSUIZAKA Mitsuteru
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Hokkaido University
  •  Micro RNA profiles in pancreatic cancer

    • Principal Investigator
      KAWAKUBO Kazumichi
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Hokkaido University

All 2020 2019 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

  • [Journal Article] High serum angiopoietin‐2 level predicts non‐regression of liver stiffness measurement‐based liver fibrosis stage after direct‐acting antiviral therapy for hepatitis C2020

    • Author(s)
      Kawagishi Naoki、Suda Goki、Kimura Megumi、Maehara Osamu、Shimazaki Tomoe、Yamada Ren、Kitagataya Takashi、Shigesawa Taku、Suzuki Kazuharu、Nakamura Akihisa、Ohara Masatsugu、Umemura Machiko、Nakai Masato、Sho Takuya、Natsuizaka Mitsuteru、Morikawa Kenichi、Ogawa Koji、Kudo Yusuke、Nishida Mutsumi、Sakamoto Naoya
    • Journal Title

      Hepatology Research

      Volume: in press Issue: 6 Pages: 671-681

    • DOI

      10.1111/hepr.13490

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07959, KAKENHI-PROJECT-19K08458, KAKENHI-PROJECT-20K21592, KAKENHI-PROJECT-20K17008, KAKENHI-PROJECT-19H03630
  • [Journal Article] Metformin Regulates the Expression of CD133 Through the AMPK-CEBPβ Pathway in Hepatocellular Carcinoma Cell Lines2019

    • Author(s)
      Maehara Osamu、Ohnishi Shunsuke、Asano Ayaka、Suda Goki、Natsuizaka Mitsuteru、Nakagawa Koji、Kobayashi Masanobu、Sakamoto Naoya、Takeda Hiroshi
    • Journal Title

      Neoplasia

      Volume: 21 Issue: 6 Pages: 545-556

    • DOI

      10.1016/j.neo.2019.03.007

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07959, KAKENHI-PROJECT-17K09344
  • [Journal Article] Distinct effects of EGFR inhibitors on epithelial- and mesenchymal-like esophageal squamous cell carcinoma cells.2017

    • Author(s)
      Yoshioka M, Ohashi S, Ida T, Nakai Y, Kikuchi O, Amanuma Y, Matsubara J, Yamada A, Miyamoto S, Natsuizaka M, Nakagawa H, Chiba T, Seno H, Muto M.
    • Journal Title

      J Exp Clin Cancer Res.

      Volume: 36 Issue: 1 Pages: 101-101

    • DOI

      10.1186/s13046-017-0572-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09281, KAKENHI-PROJECT-15K08943
  • [Journal Article] Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma2017

    • Author(s)
      Natsuizaka M、Whelan KA、Kagawa S、Tanaka K、Giroux V、Chandramouleeswaran PM、Long A、Sahu V、Darling DS、Que J、Yang Y、Katz JP、Wileyto E、Basu、Kita Y、Natsugoe S、Naganuma S、Klein-Szanto AJ、Diehl JA、Bass AJ、Wong Kwok-Kin、Rustgi AK、Nakagawa H
    • Journal Title

      Nat Commun

      Volume: 8 Issue: 1 Pages: 1758-1758

    • DOI

      10.1038/s41467-017-01500-9

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08943, KAKENHI-PROJECT-15K10108, KAKENHI-PROJECT-17H04285
  • [Journal Article] Fibroblast growth factor-2-mediated FGFR/Erk signaling supports maintenance of cancer stem-like cells in esophageal squamous cell carcinoma2017

    • Author(s)
      Osamu Maehara, Goki Suda et al.
    • Journal Title

      Carcinogenesis

      Volume: 38 Issue: 11 Pages: 1073-1083

    • DOI

      10.1093/carcin/bgx095

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09334, KAKENHI-PROJECT-17K09400, KAKENHI-PROJECT-16H05282, KAKENHI-PROJECT-17J00434, KAKENHI-PROJECT-15K08943
  • [Journal Article] Efficacy and safety of daclatasvir and asunaprevir combination therapy in chronic hemodialysis patients with chronic hepatitis C.2016

    • Author(s)
      Suda G, Kudo M, Nagasaka A, Furuya K, Yamamoto Y, Kobayashi T, Shinada K, Tateyama M, Konno J, Tsukuda Y, Yamasaki K, Kimura M, Umemura M, Izumi T, Tsunematsu S, Sato F, Terashita K, Nakai M, Horimoto H, Sho T, Natsuizaka M, Morikawa K, Ogawa K, Sakamoto N
    • Journal Title

      J Gastroenterol Hepatol

      Volume: EPub Issue: 7 Pages: 733-740

    • DOI

      10.1007/s00535-016-1162-8

    • NAID

      120006313426

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26670375, KAKENHI-PROJECT-26461021, KAKENHI-PROJECT-15K08943
  • [Journal Article] Fluorescent imaging of superficial head and neck squamous cell carcinoma using a γ-glutamyltranspeptidase-activated targeting agent: a pilot study.2016

    • Author(s)
      Mizushima T, Ohnishi S, Shimizu Y, Hatanaka Y, Hatanaka KC, Hosono H, Kubota Y, Natsuizaka M, Kamiya M, Ono S, Homma A, Kato M, Sakamoto N, Urano Y
    • Journal Title

      BMC Cancer

      Volume: 16 Issue: 1 Pages: 411-411

    • DOI

      10.1186/s12885-016-2421-z

    • NAID

      120005773989

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-15H05951, KAKENHI-PROJECT-16H02606, KAKENHI-PROJECT-26460933, KAKENHI-PROJECT-26461043, KAKENHI-PROJECT-15K08943
  • [Journal Article] Anti-adipogenic and antiviral effects of l-carnitine on hepatitis C virus infection.2016

    • Author(s)
      Tsukuda Y, Suda G, Tsunematsu S, Ito J, Sato F, Terashita K, Nakai M, Sho T, Maehara O, Shimazaki T, Kimura M, Morikawa K, Natsuizaka M, Ogawa K, Ohnishi S, Chuma M, Sakamoto N
    • Journal Title

      J Med Virol

      Volume: 89 Issue: 5 Pages: 857-866

    • DOI

      10.1002/jmv.24692

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05282, KAKENHI-PROJECT-26460982, KAKENHI-PROJECT-26461021, KAKENHI-PROJECT-15K08943, KAKENHI-PROJECT-15K08980, KAKENHI-PROJECT-16K09334, KAKENHI-PROJECT-16K15420
  • [Journal Article] ZEB1 expression is associated with prognosis of intrahepatic cholangiocarcinoma2016

    • Author(s)
      Terashita K, Chuma M, Hatanaka Y, Hatanaka K, Mitsuhashi T, Yokoo H, Ohmura T, Ishizu H, Muraoka S, Nagasaka A, Tsuji T, Yamamoto Y, Kurauchi N, Shimoyama N, Toyoda H, Kumada T, Kaneoka Y, Maeda A, Ogawa K, Natsuizaka M, Kamachi H, Kakisaka T, Kamiyama T, Taketomi A, Matsuno Y, Sakamoto N
    • Journal Title

      J Clin Pathol

      Volume: in press Issue: 7 Pages: 593-599

    • DOI

      10.1136/jclinpath-2015-203115

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K08980, KAKENHI-PROJECT-25460449, KAKENHI-PROJECT-24590674, KAKENHI-PROJECT-26670375, KAKENHI-PROJECT-26460982, KAKENHI-PROJECT-15K08943, KAKENHI-PROJECT-16K08684
  • [Journal Article] Human Amnion-Derived Mesenchymal Stem Cell Transplantation Ameliorates Dextran Sulfate Sodium-Induced Severe Colitis in Rats.2015

    • Author(s)
      Onishi R, Ohnishi S, Higashi R, Watari M, Yamahara K, Okubo N, Nakagawa K, Katsurada T, Suda G, Natsuizaka M, Takeda H, Sakamoto N.
    • Journal Title

      Cell Transplant

      Volume: 24 Issue: 12 Pages: 26012614-26012614

    • DOI

      10.3727/096368915x687570

    • NAID

      120005690898

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K08943
  • [Journal Article] EGFR inhibitors prevent induction of cancer stem-like cells in esophageal squamous cell carcinoma by suppressing epithelial-mesenchymal transition.2015

    • Author(s)
      Sato F, Kubota Y, Natsuizaka M, Maehara O, Hatanaka Y, Marukawa K, Terashita K, Suda G, Ohnishi S, Shimizu Y, Komatsu Y, Ohashi S, Kagawa S, Kinugasa H, Whelan KA, Nakagawa H, Sakamoto N.
    • Journal Title

      Cancer Biol Ther

      Volume: 16 Issue: 6 Pages: 933940-933940

    • DOI

      10.1080/15384047.2015.1040959

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K08943, KAKENHI-PROJECT-26460933, KAKENHI-PROJECT-25460921
  • [Journal Article] A pivotal role of Krüppel-like factor 5 in regulation of cancer stem-like cells in hepatocellular carcinoma.2015

    • Author(s)
      Maehara O, Sato F, Natsuizaka M, Asano A, Kubota Y, Itoh J, Tsunematsu S, Terashita K, Tsukuda Y, Nakai M, Sho T, Suda G, Morikawa K, Ogawa K, Chuma M, Nakagawa K, Ohnishi S, Komatsu Y, Whelan KA, Nakagawa H, Takeda H, Sakamoto N.
    • Journal Title

      Cancer Biol Ther

      Volume: 16 Issue: 10 Pages: 14531461-14531461

    • DOI

      10.1080/15384047.2015.1070992

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K08943, KAKENHI-PROJECT-15K08980, KAKENHI-PROJECT-26460933, KAKENHI-PROJECT-26461021
  • [Journal Article] CTNNB1 mutational analysis of solid-pseudopapillary neoplasms of the pancreas using EUS-guided fine-needle aspiration and next-generation deep sequencing2014

    • Author(s)
      Kubota Y, Kawakami H, Natsuizaka M, Kawakubo K, Marukawa K, Kudo T, Abe Y, Kubo K, Kuwatani M, Hatanaka Y, Mitsuhashi T, Matsuno Y, Sakamoto N.
    • Journal Title

      Journal of gastroenterology

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25860512
  • [Journal Article] IGFBP3 promotes esophageal cancer growth by suppressing oxidative stress in hypoxic tumor microenvironment2014

    • Author(s)
      Natsuizaka M, Kinugasa H, Kagawa S, Whelan KA, Naganuma S, Subramanian H, Chang S, Nakagawa KJ, Rustgi NL, Kita Y, Natsugoe S, Basu D, Gimotty PA, Klein-Szanto AJ, Diehl JA, Rustgi AK and Nakagawa H.
    • Journal Title

      American journal of cancer research

      Volume: 4 Pages: 29-41

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25860512
  • [Journal Article] CTNNB1 mutational analysis of solid-pseudopapillary neoplasms of the pancreas using endoscopic ultrasound-guided fine-needle aspiration and next-generation deep sequencing.2014

    • Author(s)
      Kubota Y, Kawakami H, Natsuizaka M, Kawakubo K, Marukawa K, Kudo T, Abe Y, Kubo K, Kuwatani M, Hatanaka Y, Mitsuhashi T, Matsuno Y, Sakamoto N.
    • Journal Title

      J Gastroenterol.

      Volume: in press Issue: 2 Pages: 203-210

    • DOI

      10.1007/s00535-014-0954-y

    • NAID

      120005693897

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591007, KAKENHI-PROJECT-24590674, KAKENHI-PROJECT-25460449, KAKENHI-PROJECT-25860514
  • [Journal Article] Heat shock factor 1 accelerates hepatocellular carcinoma development by activating nuclear factor κB/mitogen-activated protein kinase.2014

    • Author(s)
      Chuma M, Sakamoto N, Nakai A, Hige S, Nakanishi M, Natsuizaka M, Suda G, Sho T, Hatakaka K, Matsuno Y, Yokoo H, Kamiyama T, Taketomi A, Fujii G, Tashiro K, Hikiba Y, Fujimoto M, Asaka M, Maeda S
    • Journal Title

      Carcinogenesis

      Volume: Epub ahead of print Issue: 2 Pages: 272-281

    • DOI

      10.1093/carcin/bgt343

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659359, KAKENHI-PROJECT-25440010, KAKENHI-PROJECT-25860512, KAKENHI-PROJECT-25860513, KAKENHI-PROJECT-26460982
  • [Presentation] FGFR阻害剤およびMEK阻害剤は食道扁平上皮癌(ESCC)がん幹細胞を減少させる2020

    • Author(s)
      前原経、夏井坂光輝、武田宏司
    • Organizer
      第16回日本消化管学会総会学術集会
    • Data Source
      KAKENHI-PROJECT-18K07959
  • [Presentation] TGF-β in tumor microenvironment changes a switch of Notch1-mediated signaling to maintain cancer stem-like cells in esophageal squamous cell carcinoma2014

    • Author(s)
      Natsuizaka M, Kagawa S, Whelan K, Ohashi S, Ohnishi S, Suda G, Sakamoto N, Rustgi AK, Nakagawa H
    • Organizer
      An AACR special conference on cellular heterogeneity in the tumor microenvironment.
    • Place of Presentation
      The Westin San Diego Gaslamp Quarter (San Diego, USA)
    • Data Source
      KAKENHI-PROJECT-25860512
  • [Presentation] TGF-β changes a switch of Notch1-mediated signaling to maintain tumor-initiating cells in esophageal SCC (ESCC)2013

    • Author(s)
      Natsuizaka M, Ohashi S, Naganuma S, Ohnishi S, Kuwatani M, Kawakami H, Chuma M, Komatsu Y, Kato M, Sakamoto N
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Data Source
      KAKENHI-PROJECT-25860512
  • [Presentation] 上皮間葉移行(EMT)による食道扁平上皮癌がん幹細胞維持・増幅機構2013

    • Author(s)
      夏井坂光輝、中川裕、坂本直哉
    • Organizer
      日本消化器病関連週間2013 ワークショップ「消化器癌における幹細胞研究の現状と展望」
    • Place of Presentation
      グランドプリンスホテル新高輪(東京)
    • Data Source
      KAKENHI-PROJECT-25860512
  • [Presentation] Transforming Growth Factor-beta and Notch1 Cooperate to Repress NOTCH3 to Facilitate Epithelial-Mesenchymal Transition and Tumor Initiating Capability in Esophageal Squamous Cell Carcinoma2013

    • Author(s)
      Natsuizaka M, Kagawa S, Whelan KA, Chang S, Kinugasa H, Ohashi S, Naganuma S, Sakamoto N, Klein-Szanto AJ, Gimotty PA, Diehl JA, Herlyn M, Rustgi AK, Nakagawa H.
    • Organizer
      Digestive Disease Week and the 114th annual meeting of the American Gastroenterological Association
    • Place of Presentation
      Orange county convention center (Orlando, USA)
    • Data Source
      KAKENHI-PROJECT-25860512
  • [Presentation] EGFR inhibitors eliminate esophageal cancer stem cells by suppressing epithelial-mesenchymal transition.

    • Author(s)
      Mitsuteru Natsuizaka, Bongani Kaimila, Yoshimasa Kubota, Yutaka Hatanaka, Katsuji Marukawa, Katsumi Terashita, Fumiyuki Sato, Shunsuke Ohnishi, Goki Suda, Shinya Ohashi, Shingo Kagawa, Kelly Whelan, Anil K Rustgi, Hiroshi Nakagawa, Naoya Sakamoto
    • Organizer
      Digestive Disease Week and the 115th annual meeting of the American Gastroenterological Association
    • Place of Presentation
      McCormick Place (Chicago, USA)
    • Year and Date
      2014-05-03 – 2014-05-06
    • Data Source
      KAKENHI-PROJECT-25860512
  • [Presentation] EGFR inhibitors suppress epithelial-mesenchymal transition and diminish cancer stem-like cells in esophageal squamous cell carcinoma

    • Author(s)
      Fumiyuki Sato, Mitsuteru Natsuizaka, Shinya Ohashi, Shingo Kagawa, Masaki Kuwatai, Hiroshi Kawakami, Shunsuke Ohnishi, Yoshito Komatsu, Mototsugu Kato, Naoya Sakamoto
    • Organizer
      第73回 日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-26460933
  • [Presentation] EGFR inhibitors eliminate esophageal cancer stem cells by suppressing epithelial-mesenchymal transition.

    • Author(s)
      Natsuizaka M, Kaimila B, Kubota Y, Hatanaka Y, Marukawa K, Terashita K, Sato F, Ohnishi S, Suda G, Ohashi S, Kagawa S, Whelan K, Rustgi AK, Nakagawa H, Sakamoto N.
    • Organizer
      Digestive Disease Week and the 115th annual meeting of the American Gastroenterological Association.
    • Place of Presentation
      McCormick Place (Chicago, USA)
    • Year and Date
      2014-05-03 – 2014-05-06
    • Data Source
      KAKENHI-PROJECT-26460933
  • 1.  前原 経 (80836338)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 2.  KAWAKUBO Kazumichi (80633578)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  KAWAKAMI Hiroshi (80399823)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 4.  Yoshito Komatsu (60333598)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 5.  須田 剛生 (20447460)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 6.  KUBOTA Yoshimasa
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  大橋 真也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  坂本 直哉
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 9.  神谷 真子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  中西 満
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  森川 賢一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  大西 俊介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  小川 浩司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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