kobayashi kyosuke 小林郷介

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KOBAYASHI Kyousuke 小林郷介

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Researcher Number	80644989
Other IDs
Affiliation (Current)	2025: 公益財団法人東京都医学総合研究所, 疾患制御研究分野, 主席研究員 2025: 公益財団法人東京都医学総合研究所, 感染症医学研究センター, 主席研究員
Affiliation (based on the past Project Information) *help	2020 – 2025: 公益財団法人東京都医学総合研究所, 疾患制御研究分野, 主席研究員 2019: 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 主席研究員 2018: 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 主任研究員 2016: 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 主任研究員 2015: 東京大学, 医科学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 49060:Virology-related / Virology Except Principal Investigator Basic Section 49060:Virology-related
Keywords	Principal Investigator ウイルス / 神経細胞 / ピコルナウイルス / エンテロウイルス / 受容体 / エンテロウイルス71 / 神経感染症 / レセプター / tyrosine kinase / tropism … More / receptor / enterovirus / 組織特異性 / エンテロウイルス７１ / 宿主因子 / EV71 / 組織指向性 / Rho GTPase / ウイルス学 / エンベロープ形成 / ゴルジ体 / miRNA / ヘルペスウイルス … More Except Principal Investigator 相同組換え / 騒動組換え / 点突然変異 / 神経病原性 / 病原性 / エンテロウイルス７１ Less

EV-A71経口感染メカニズムの解明Principal Investigator
- Principal Investigator
  
  小林郷介
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Analysis of neuron-specific receptors for enterovirus A71Principal Investigator
- Principal Investigator
  
  小林郷介
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Exploration of host factors involved in the tissue specificity of enterovirus 71Principal Investigator
- Principal Investigator
  
  KOBAYASHI Kyousuke
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Studies on viral factors that contribute to severe infection of enterovirus 71
- Principal Investigator
  
  KOIKE Satoshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Study of the host factor important for secondary envelopment of HSV-1Principal Investigator
- Principal Investigator
  
  KOBAYASHI Kyousuke
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
  The University of Tokyo

All 2023 2022 2021 2020 2019 2018 2016 2015

All Journal Article Presentation

[Journal Article] Mouse Scarb2 Modulates EV-A71 Pathogenicity in Neonatal Mice2022
- Author(s)
  Miwatashi Wakako、Ishida Minori、Takashino Ayako、Kobayashi Kyousuke、Yamaguchi Midori、Shitara Hiroshi、Koike Satoshi
- Journal Title
  
  Journal of Virology
  
  Volume: 96 Issue: 15 Pages: 3330-3337
- DOI
  10.1128/jvi.00561-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07601, KAKENHI-PROJECT-23K24143
[Journal Article] TAK-021, an inactivated Enterovirus 71 vaccine candidate, provides cross-protection against heterologous sub-genogroups in human scavenger receptor B2 transgenic mice2022
- Author(s)
  Tamura Kanami、Kohnoe Mai、Takashino Ayako、Kobayashi Kyousuke、Koike Satoshi、Karwal Lovkesh、Fukuda Shigeru、Vang Fue、Das Subash C.、Dean Hansi J.
- Journal Title
  
  Vaccine
  
  Volume: 40 Issue: 24 Pages: 3330-3337
- DOI
  10.1016/j.vaccine.2022.04.064
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07601, KAKENHI-PROJECT-23K24143
[Journal Article] Adaptation and Virulence of Enterovirus-A712021
- Author(s)
  Kobayashi Kyousuke、Koike Satoshi
- Journal Title
  
  Viruses
  
  Volume: 13 Issue: 8 Pages: 1661-1661
- DOI
  10.3390/v13081661
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07601
[Journal Article] Virulence of Enterovirus A71 Fluctuates Depending on the Phylogenetic Clade Formed in the Epidemic Year and Epidemic Region2021
- Author(s)
  Kobayashi Kyousuke、Nishimura Hidekazu、Mizuta Katsumi、Nishizawa Tomoha、Chu Son T.、Ichimura Hiroshi、Koike Satoshi
- Journal Title
  
  Journal of Virology
  
  Volume: 95 Issue: 23
- DOI
  10.1128/jvi.01515-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07601
[Journal Article] Newly emerged enterovirus-A71 C4 sublineage may be more virulent than B5 in the 2015?2016 hand-foot-and-mouth disease outbreak in northern Vietnam2020
- Author(s)
  Chu Son T.、Kobayashi Kyousuke、Bi Xiuqiong、Ishizaki Azumi、Tran Tu T.、Phung Thuy T. B.、Pham Chung T. T.、Nguyen Lam V.、Ta Tuan A.、Khu Dung T. K.、Agoh Masanobu、Pham An N.、Koike Satoshi、Ichimura Hiroshi
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 159-159
- DOI
  10.1038/s41598-019-56703-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07601, KAKENHI-PROJECT-16H05842, KAKENHI-PROJECT-18H02667, KAKENHI-PROJECT-17K10100
[Journal Article] Development of an Enterovirus 71 Vaccine Efficacy Test Using Human Scavenger Receptor B2 Transgenic Mice2020
- Author(s)
  Imura Ayumi、Sudaka Yui、Takashino Ayako、Tamura Kanami、Kobayashi Kyousuke、Nagata Noriyo、Nishimura Hidekazu、Mizuta Katsumi、Koike Satoshi
- Journal Title
  
  Journal of Virology
  
  Volume: 94 Issue: 6 Pages: 1-14
- DOI
  10.1128/jvi.01921-19
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07601, KAKENHI-PROJECT-19H03626
[Journal Article] Cellular receptors for enterovirus A712020
- Author(s)
  Kobayashi Kyousuke、Koike Satoshi
- Journal Title
  
  Journal of Biomedical Science
  
  Volume: 27 Issue: 1 Pages: 23-23
- DOI
  10.1186/s12929-020-0615-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07601, KAKENHI-PROJECT-18H02667
[Journal Article] Heparan sulfate attachment receptor is a major selection factor for attenuated enterovirus 71 mutants during cell culture adaptation2020
- Author(s)
  Kobayashi Kyousuke、Mizuta Katsumi、Koike Satoshi
- Journal Title
  
  PLOS Pathogens
  
  Volume: 16 Issue: 3 Pages: e1008428-e1008428
- DOI
  10.1371/journal.ppat.1008428
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07601, KAKENHI-PROJECT-18H02667
[Journal Article] VP1 Amino Acid Residue 145 of Enterovirus 71 Is a Key Residue for Its Receptor Attachment and Resistance to Neutralizing Antibody during Cynomolgus Monkey Infection2018
- Author(s)
  Fujii Ken、Sudaka Yui、Takashino Ayako、Kobayashi Kyousuke、Kataoka Chikako、Suzuki Tadaki、Iwata-Yoshikawa Naoko、Kotani Osamu、Ami Yasushi、Shimizu Hiroyuki、Nagata Noriyo、Mizuta Katsumi、Matsuzaki Yoko、Koike Satoshi
- Journal Title
  
  Journal of Virology
  
  Volume: 92 Issue: 15 Pages: 1-17
- DOI
  10.1128/jvi.00682-18
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05200, KAKENHI-PROJECT-18H02667, KAKENHI-PROJECT-15K08511
[Journal Article] Amino Acid Variation at VP1-145 of Enterovirus 71 Determines Attachment Receptor Usage and Neurovirulence in Human Scavenger Receptor B2 Transgenic Mice2018
- Author(s)
  Kyousuke Kobayashi, Yui Sudaka, Ayako Takashino, Ayumi Imura, Ken Fujii, Satoshi Koike
- Journal Title
  
  Journal of Virology
  
  Volume: 92 Issue: 15
- DOI
  10.1128/jvi.00681-18
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02667
[Journal Article] 1.Pull-down method to access the cell surface receptor for Toxoplasma gondii.2016
- Author(s)
  Gong H, Kobayashi K, Sugi T, Takemae H, Horimoto T, Xuan X, Akashi H, Kato K
- Journal Title
  
  Parasitol. Int.
  
  Volume: 65 Issue: 5 Pages: 514-515
- DOI
  10.1016/j.parint.2016.08.013
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19108, KAKENHI-PUBLICLY-15H01306
[Journal Article] 2.Evaluating the use of heparin for synchronization of in vitro culture of Plasmodium falciparum.2016
- Author(s)
  Kobayashi K, Kato K.
- Journal Title
  
  Parasitol. Int.
  
  Volume: 65 Issue: 5 Pages: 549-551
- DOI
  10.1016/j.parint.2016.09.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19108, KAKENHI-PUBLICLY-15H01306
[Journal Article] Dynamics and plasticity of the epithelial to mesenchymal transition induced by miR-200 family inhibition2016
- Author(s)
  Haraguchi, T, Kondo, M, Uchikawa, R, Kobayashi, K, Hiramatsu, H, Kobayashi, K , Chit, UW, Shimizu, T, Iba, H.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 1-12
- DOI
  10.1038/srep21117
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26430109, KAKENHI-PROJECT-15K19108, KAKENHI-PLANNED-24115007
[Presentation] EV-A71 IRES の重症化因子の研究2023
- Author(s)
  小林郷介, 野村奈美子, 西澤朋葉, Chu Than Son, 市村宏, 小池智
- Organizer
  第70回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24143
[Presentation] EV71 IRESの重症化因子の研究2023
- Author(s)
  小林郷介
- Organizer
  第17回ウイルス学キャンプ
- Data Source
  KAKENHI-PROJECT-23K24143
[Presentation] ヒトパレコウイルスA3の感染には吸着受容体としてのヘパラン硫酸が不可欠である2023
- Author(s)
  姫田敏樹, 大桑孝子, 小林郷介, 野村奈美子, 宇谷公一, 小池智, 樋口雅也
- Organizer
  第70回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24143
[Presentation] CRISPR/Cas9システムを用いたSaffold virus受容体の同定2023
- Author(s)
  大桑孝子, 姫田敏樹, 小林郷介, 野村奈美子, 宇谷公一, 小池智, 樋口雅也
- Organizer
  第70回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24143
[Presentation] Two nucleotide mutations in IRES stem-loop IV define neuron-specific EV-A71 proliferation2022
- Author(s)
  K. Kobayashi、N. Nomura、A. Ohkubo、T. Nishizawa、S. Koike
- Organizer
  The 20th Awaji International Forum on Infection and Immunity
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07601
[Presentation] Two nucleotide mutations in IRES stem-loop IV define neuron-specific EV-A71 proliferation2022
- Author(s)
  K. Kobayashi , N. Nomura , A. Ohkubo , T. Nishizawa , S. Koike
- Organizer
  The 20th Awaji International Forum on Infection and Immunity
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24143
[Presentation] Analysis of two nucleotides on the internal ribosome entry site regulating the EV-A71 neurovirulence2021
- Author(s)
  小林郷介, 西澤朋葉, 小池智
- Organizer
  第68回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07601
[Presentation] Identification of two nucleotides on IRES that control the neurovirulence of EV712021
- Author(s)
  小林郷介, 西澤朋葉, 小池智
- Organizer
  The 19th Awaji International Forum on Infection and Immunity
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07601
[Presentation] An inactivated EV71 vaccine candidate provides cross-protection against heterogous subgenotypes in human SCARB2 transgenic mice2020
- Author(s)
  Subash CD, Larwal L, Springer Z, Vang, Tamura K, Takashino A, Kobayashi K, Koike S, Adachi S, Fukuda S, Thomson , Rao R, Dean H
- Organizer
  American Society for Virology 39th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02667
[Presentation] Virulence analysis of enterovirus 71 isolated from Hand-foot-mouth disease patients in Japan and Vietnam for identification of virulence determinant2019
- Author(s)
  Kobayashi K, Chu ST, Mizuta K, Nishimura H, Ichimura H, Koike S
- Organizer
  the 67th annual meeting of the Japansese society for virology
- Data Source
  KAKENHI-PROJECT-18H02667
[Presentation] Virulence analysis of enterovirus71 isolated from hand-foot-and-mouth disease patients in Japan and Vietnam for identification of virulence determinant.2019
- Author(s)
  小林郷介、Chu SonThanh、水田克己、西村秀一、市村宏、小池智
- Organizer
  第67回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07601
[Presentation] Use of attachment receptor, heparan sulfate proteoglycan, negatively affects neurovirulence of VP1-145 variants of enterovirus 712018
- Author(s)
  Kobayashi K, Sudaka Y, Takashino A, Imura A, Fujii K, Koike S
- Organizer
  The 20 th Meeting of the European Study Group on the Molecular Biology of Picornaviruses
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02667
[Presentation] Tissue culture adaptation of enterovirus 71 selects mutant viruses that bind to HS and are attenuated in vivo2018
- Author(s)
  Kobayashi K, Son Thanh Chu, Takashino A, Aoki Y, Matoba Y, Mizuta K, Nishimura H, Ichimura H, Koike S
- Organizer
  The 66th Annual Meeting of The Japanese Society for Virology
- Data Source
  KAKENHI-PROJECT-18H02667
[Presentation] Epidemiological and Virological Characterization of the Enterovirus Causing Hand Foot and Mouth Disease in Northern Vietnam, 2015-20112018
- Author(s)
  Son Thanh Chu, Bi X, Ishizaki A, Masanobu Ago M, yousuke Kobayashi K, Koike, S Ichimura H
- Organizer
  The 66th Annual Meeting of The Japanese Society for Virology
- Data Source
  KAKENHI-PROJECT-18H02667
[Presentation] 宿主miRNAによるウイルス増殖阻害に関する研究2015
- Author(s)
  小林郷介
- Organizer
  第12回ウイルス学キャンプ
- Place of Presentation
  ニューウェルシティ湯河原（静岡県熱海市）
- Year and Date
  2015-05-23
- Data Source
  KAKENHI-PROJECT-15K19108
[Presentation] Antiviral host miRNA, miR-199a, regulates Cdc42 activity on the Golgi to inhibit HSV-1 secondary envelopment2015
- Author(s)
  小林郷介
- Organizer
  第14回あわじしま感染症・免疫フォーラム
- Place of Presentation
  淡路夢舞台国際会議場（兵庫県淡路市）
- Year and Date
  2015-09-08
- Data Source
  KAKENHI-PROJECT-15K19108
[Presentation] MiR-199a inhibits secondary envelopment of HSV-1 by suppressing a Golgi-localized GAP for Cdc422015
- Author(s)
  小林郷介
- Organizer
  第63回日本ウイルス学会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-15K19108
[Presentation] HSV-1の2次エンベロープ形成を阻害する宿主miRNAの標的因子の研究2015
- Author(s)
  小林郷介
- Organizer
  第2回感染コンピテンシー若手研究会
- Place of Presentation
  マホロバマインズ三浦（神奈川県三浦市）
- Year and Date
  2015-07-17
- Data Source
  KAKENHI-PROJECT-15K19108

1. KOIKE Satoshi (30195630)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
2. 市村宏 (10264756)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. IBA Hideo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. SAGARA Hiroshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. HARAGUCHI Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 清水博之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 伊庭英生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

kobayashi kyosuke 小林 郷介

KOBAYASHI Kyousuke 小林 郷介

Research Projects

Research Products

Co-Researchers

EV-A71経口感染メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of neuron-specific receptors for enterovirus A71Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploration of host factors involved in the tissue specificity of enterovirus 71Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studies on viral factors that contribute to severe infection of enterovirus 71

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of the host factor important for secondary envelopment of HSV-1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Mouse Scarb2 Modulates EV-A71 Pathogenicity in Neonatal Mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TAK-021, an inactivated Enterovirus 71 vaccine candidate, provides cross-protection against heterologous sub-genogroups in human scavenger receptor B2 transgenic mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Adaptation and Virulence of Enterovirus-A712021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Virulence of Enterovirus A71 Fluctuates Depending on the Phylogenetic Clade Formed in the Epidemic Year and Epidemic Region2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Newly emerged enterovirus-A71 C4 sublineage may be more virulent than B5 in the 2015?2016 hand-foot-and-mouth disease outbreak in northern Vietnam2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of an Enterovirus 71 Vaccine Efficacy Test Using Human Scavenger Receptor B2 Transgenic Mice2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cellular receptors for enterovirus A712020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Heparan sulfate attachment receptor is a major selection factor for attenuated enterovirus 71 mutants during cell culture adaptation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] VP1 Amino Acid Residue 145 of Enterovirus 71 Is a Key Residue for Its Receptor Attachment and Resistance to Neutralizing Antibody during Cynomolgus Monkey Infection2018

Author(s)

Journal Title

DOI

Data Source

kobayashi kyosuke 小林郷介

KOBAYASHI Kyousuke 小林郷介