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Ouchi Ayumi  大内 亜由美

ORCIDConnect your ORCID iD *help
… Alternative Names

臼井 亜由美  ウスイ アユミ

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Researcher Number 80645664
Other IDs
Affiliation (Current) 2023: 順天堂大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help 2021 – 2023: 順天堂大学, 医学部, 准教授
2017 – 2019: 順天堂大学, 医学部, 非常勤助教
2014 – 2016: 順天堂大学, 医学部, 助教
Review Section/Research Field
Principal Investigator
Basic Section 56060:Ophthalmology-related / Ophthalmology
Keywords
Principal Investigator
マイクログリア / 糖尿病網膜症 / 網膜オルガノイド / 網膜3次元培養 / 網膜新生血管 / 網膜マイクログリア / 加齢黄斑変性症 / 未熟児網膜症 / 網膜血管新生 / 硝子体 … More / 網膜色素上皮細胞 / microRNA-21 / microRNA / 上皮間葉系移行 / マイクロRNA / 増殖硝子体網膜症 / 増殖糖尿病網膜症 Less
  • Research Projects

    (4 results)
  • Research Products

    (18 results)
  •  ヒト網膜オルガノイドとマイクログリア共培養系を用いた難治性網膜疾患の病態解明Principal Investigator

    • Principal Investigator
      大内 亜由美
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
    • Review Section
      Basic Section 56060:Ophthalmology-related
    • Research Institution
      Juntendo University
  •  ヒト網膜オルガノイドとマイクログリア共培養系を用いた糖尿病網膜症メカニズムの解明Principal Investigator

    • Principal Investigator
      大内 亜由美
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56060:Ophthalmology-related
    • Research Institution
      Juntendo University
  •  The molecular and functional analysis of retinal microglia in diabetic retinopathyPrincipal Investigator

    • Principal Investigator
      Usui-Ouchi Ayumi
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Ophthalmology
    • Research Institution
      Juntendo University
  •  Investigation of microNRA expression and function in vitreous of proliferative vitreoretinal diseases.Principal Investigator

    • Principal Investigator
      Ouchi Ayumi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Ophthalmology
    • Research Institution
      Juntendo University

All 2022 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

  • [Journal Article] Retinal microglia are critical for subretinal neovascular formation2020

    • Author(s)
      Usui-Ouchi Ayumi、Usui Yoshihiko、 Kurihara Toshihide、 Aguilar Edith、Dorrell Michael、Ideguchi Yoichiro、Sakimoto Susumu、Bravo Stephen、and Friedlander Martin
    • Journal Title

      JCI insight

      Volume: in press

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K16984
  • [Journal Article] 飛蚊症の自覚から網膜剥離発見までの期間について2019

    • Author(s)
      佐久間 俊郎, 大内 亜由美, 坂西 良仁, 伊藤 玲, 清川 正敏, 海老原 伸行
    • Journal Title

      眼科臨床紀要

      Volume: 12 (1) Pages: 5-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K16984
  • [Journal Article] Anti-VEGF therapy: higher potency and long-lasting antagonism are not necessarily better2019

    • Author(s)
      Usui-Ouchi Ayumi、Friedlander Martin
    • Journal Title

      Journal of Clinical Investigation

      Volume: 129 Issue: 8 Pages: 3032-3034

    • DOI

      10.1172/jci129862

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K16984
  • [Journal Article] Three Cases of Creutzfeldt-Jakob Disease with Visual Disturbances as Initial Manifestation2019

    • Author(s)
      Sakuma Toshiro、Watanabe Satoshi、Ouchi Ayumi、Sakanishi Yoshihito、Mizota Atsushi、Ebihara Nobuyuki
    • Journal Title

      Case Reports in Ophthalmology

      Volume: 10 Issue: 3 Pages: 349-356

    • DOI

      10.1159/000503274

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K16984
  • [Journal Article] 特集 第71回日本臨床眼科学会講演集[6] 原著 治療開始後に肺結核への罹患が判明した糖尿病網膜症3例2018

    • Author(s)
      玉城麻夏、大内亜由美、坂西良仁、李亜美、海老原伸行
    • Journal Title

      臨床眼科

      Volume: 72 Issue: 8 Pages: 1161-1167

    • DOI

      10.11477/mf.1410212793

    • ISSN
      0370-5579, 1882-1308
    • Year and Date
      2018-08-15
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K16984
  • [Journal Article] 基礎研究コラム 15.microRNAの臨床応用の可能性2018

    • Author(s)
      大内亜由美
    • Journal Title

      あたらしい眼科

      Volume: 35(8) Pages: 1099-1099

    • Data Source
      KAKENHI-PROJECT-17K16984
  • [Journal Article] Short-term outcomes in patients with branch retinal vein occlusion who received intravitreal aflibercept with or without intravitreal ranibizumab.2017

    • Author(s)
      Sakanishi Y, Usui-Ouchi A, Tamaki K, Mashimo K, Ito R, Ebihara N.
    • Journal Title

      Clin Ophthalmol.

      Volume: 3 Pages: 829-834

    • DOI

      10.2147/opth.s133594

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K16984
  • [Journal Article] Effects of Secreted Mast Cell Mediators on Retinal Pigment Epithelial Cells: Focus on Mast Cell Tryptase.2017

    • Author(s)
      Arai R, Usui-Ouchi A, Ito Y, Mashimo K, Murakami A, Ebihara N.
    • Journal Title

      Mediators Inflamm.

      Volume: 29 Pages: 3124753-3124753

    • DOI

      10.1155/2017/3124753

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K16984
  • [Journal Article] The peroxisome proliferator-activated receptor pan-agonist bezafibrate suppresses microvascular inflammatory responses of retinal endothelial cells and vascular endothelial growth factor production in retinal pigmented epithelial cells.2017

    • Author(s)
      Usui-Ouchi A, Ouchi Y, Ebihara N.
    • Journal Title

      Int Immunopharmacol.

      Volume: 52 Pages: 70-76

    • DOI

      10.1016/j.intimp.2017.08.027

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K16984
  • [Journal Article] Upregulation of Mir-21 Levels in the Vitreous Humor Is Associated with Development of Proliferative Vitreoretinal Disease2016

    • Author(s)
      Ayumi Usui-Ouchi, Yasuo Ouchi, Masatoshi Kiyokawa, Toshiro Sakuma, Rei Ito, Nobuyuki Ebihara
    • Journal Title

      PLOS ONE

      Volume: 11 Issue: 6 Pages: e0158043-e0158043

    • DOI

      10.1371/journal.pone.0158043

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26861469, KAKENHI-PROJECT-26870683
  • [Journal Article] 眼科医のための先端医療(第159回) 網膜細胞分化におけるエピジェネティック機構とmicroRNAの役割(解説)2014

    • Author(s)
      臼井亜由美
    • Journal Title

      あたらしい眼科

      Volume: 31 Pages: 383-385

    • Data Source
      KAKENHI-PROJECT-26861469
  • [Presentation] ヒトiPS細胞由来網膜オルガノイドとマイクログリアの新規共培養モデルの開発2022

    • Author(s)
      大内亜由美, Kevin Eade, Sarah Giles, Martin Friedlander, 海老原伸行
    • Organizer
      第126回日本眼科学会総会
    • Data Source
      KAKENHI-PROJECT-21K09727
  • [Presentation] New co-culture system of human iPSC induced retinal organoid and microglia2022

    • Author(s)
      Ayumi Usui-Ouchi, Sarah Giles, Kevin Eade, Nobuyuki Ebihara, Martin Friedlander
    • Organizer
      The association for research in vision and ophthalmology(ARVO)annual meeting 2022
    • Data Source
      KAKENHI-PROJECT-21K09727
  • [Presentation] Extracellular vesicles shed from endothelial colony forming seeks (ECFCs) with high expression of CD44 are paracrine mediators of neurovasculotrophic retinal repair.2019

    • Author(s)
      Kyle Marra, Edith Aguilar, Ayumi Ouchi, Susumu Sakimoto, Martin Friedlander
    • Organizer
      ARVO annual meeting 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K16984
  • [Presentation] The role of Acid-sensing ion channel 1a in a mouse model of ischemic retinopathy2019

    • Author(s)
      Ayumi Ouchi, Edith Aguilar, Kyle Marra, Min Qiang, Yang Guang, Richard Lerner, Martin Friedlander
    • Organizer
      ARVO annual meeting 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K16984
  • [Presentation] ヒト網膜色素上皮細胞株におけるmicroRNA-21の発現と機能解析2015

    • Author(s)
      大内亜由美 海老原伸行
    • Organizer
      第119回 日本眼科学会総会
    • Place of Presentation
      ロイトン札幌(札幌)
    • Year and Date
      2015-04-16
    • Data Source
      KAKENHI-PROJECT-26861469
  • [Presentation] 眼内増殖疾患の硝子体中における分泌型 microRNA の発現解析

    • Author(s)
      臼井 亜由美、玉城 和範、清川 正敏、佐久間 俊郎、伊藤 玲、Razak Siti Razila Abdul、渡辺 すみ子
    • Organizer
      第118回 日本眼科学会総会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2014-04-02 – 2014-04-06
    • Data Source
      KAKENHI-PROJECT-26861469
  • [Presentation] ヒト 網膜色素上皮細胞株における microRNA-21 の発現と 機能解析

    • Author(s)
      大内 亜由美、海老原 伸行
    • Organizer
      第119回 日本眼科学会総会
    • Place of Presentation
      ロイトン札幌(札幌)
    • Year and Date
      2015-04-16 – 2015-04-19
    • Data Source
      KAKENHI-PROJECT-26861469

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