Yasuharu Watanabe 渡邉康春

… Alternative Names

WATANABE Yasuharu 渡邉康春

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Researcher Number	80646307
Other IDs
Affiliation (Current)	2025: 富山県薬事総合研究開発センター, その他部局等, 主任研究員
Affiliation (based on the past Project Information) *help	2020 – 2024: 富山県薬事総合研究開発センター, その他部局等, 主任研究員 2019: 富山県薬事総合研究開発センター, その他部局等, 研究員 2017 – 2018: 富山大学, 大学院医学薬学研究部(医学), 客員准教授 2016 – 2017: 富山大学, 大学院医学薬学研究部(医学), 客員講師 2014 – 2015: 富山大学, 大学院医学薬学研究部(医学), 客員助教 2013: 富山大学, 医学薬学研究部(医学), 客員助教
Review Section/Research Field	Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Metabolomics / Immunology Except Principal Investigator Basic Section 59040:Nutrition science and health science-related / Basic Section 46010:Neuroscience-general-related / Immunology
Keywords	Principal Investigator 炎症 / 肥満 / 自然免疫 / 脂肪組織 / 内臓脂肪組織 / 視床下部 / 過食 / 自然免疫センサー / 視床下部炎症 / 脂肪酸 … More / IL-1 beta / 脂肪細胞 / 好中球 / 自然炎症 / メタボリックシンドローム … More Except Principal Investigator Transcription factor / Lysine acetyaltion / Butyrate / Treg / HDAC / ウイルスベクター / AAV2-BR1N / 中和抗体 / 血液脳関門 / AAVベクター / アデノ随伴ウイルスベクター / 遺伝子治療 / レプチン抵抗性 / 摂食異常 / 視床下部炎症 / 自然免疫 Less

Role of butyrate-targeted HDAC isozyme in the regulation of intestinal inflammation
- Principal Investigator
  
  古澤之裕
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Toyama Prefectural University
視床下部炎症を誘導する自然免疫シグナル経路の解析：摂食調節異常機構の解明Principal Investigator
- Principal Investigator
  
  渡邉康春
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Toyama Prefectural Institute for Pharmaceutical Research
Development of a technique that allows repeatable gene transfer into the brain using AAV vectors
- Principal Investigator
  
  Konno Ayumu
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  Gunma University
Functional analysis of TRIF-mediated innate immune signaling in hypothalamic inflammation-induced dysregulation of food intakePrincipal Investigator
- Principal Investigator
  
  Watanabe Yasuharu
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Toyama Prefectural Institute for Pharmaceutical Research
Free fatty acids-mediated dynamic changes of neutrophils induce adipose tissue inflammationPrincipal Investigator
- Principal Investigator
  
  Watanabe Yasuharu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  University of Toyama
Elucidation of the mechanism of the innate immune signal that induces hypothalamic inflammation and feeding dysfunction
- Principal Investigator
  
  NAGAI Yoshinori
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  University of Toyama
Elucidation of regulation mechanisms of RP105/MD-1 in obesity-induced chronic inflammationPrincipal Investigator
- Principal Investigator
  
  WATANABE Yasuharu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  University of Toyama

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Book

[Book] Biological activities and action mechanisms of licorice ingredients2017
- Author(s)
  Nagai Y, Watanabe Y, Honda H, Takatsu K
- Total Pages
  172
- Publisher
  InTech
- ISBN
  9789535131205
- Data Source
  KAKENHI-PROJECT-16K19532
[Book] Chronic Inflammation: Mechanisms and Regulation2016
- Author(s)
  Nagai Y, Honda H, Watanabe Y, Takatsu K
- Total Pages
  702
- Publisher
  Springer Japan
- Data Source
  KAKENHI-PROJECT-16K19532
[Book] 自然免疫系センサーによる慢性炎症制御とメタボリック症候群2015
- Author(s)
  長井良憲, 渡邉康春, 高津聖志
- Total Pages
  6
- Publisher
  北隆館
- Data Source
  KAKENHI-PROJECT-25870257
[Journal Article] Roles of Macrophages in Advanced Liver Fibrosis, Identified Using a Newly Established Mouse Model of Diet-Induced Non-Alcoholic Steatohepatitis2022
- Author(s)
  Tada Yuki、Kasai Kaichi、Makiuchi Nana、Igarashi Naoya、Kani Koudai、Takano Shun、Honda Hiroe、Yanagibashi Tsutomu、Watanabe Yasuharu、Usui-Kawanishi Fumitake、Furusawa Yukihiro、Ichimura-Shimizu Mayuko、Tabuchi Yoshiaki、Takatsu Kiyoshi、Tsuneyama Koichi、Nagai Yoshinori
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 21 Pages: 13251-13251
- DOI
  10.3390/ijms232113251
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K05466, KAKENHI-PROJECT-22K06627, KAKENHI-PROJECT-22K07005, KAKENHI-PROJECT-22K08685
[Journal Article] Isoliquiritigenin Attenuates Adipose Tissue Inflammation and Metabolic Syndrome by Modifying Gut Bacteria Composition in Mice2022
- Author(s)
  Ishibashi Riko、Furusawa Yukihiro、Honda Hiroe、Watanabe Yasuharu、Fujisaka Shiho、Nishikawa Miyu、Ikushiro Shinichi、Kurihara Shin、Tabuchi Yoshiaki、Tobe Kazuyuki、Takatsu Kiyoshi、Nagai Yoshinori
- Journal Title
  
  Molecular Nutrition & Food Research
  
  Volume: - Issue: 10 Pages: 2101119-2101119
- DOI
  10.1002/mnfr.202101119
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07076, KAKENHI-PROJECT-19K09019, KAKENHI-PROJECT-20H03730, KAKENHI-PROJECT-20K08882, KAKENHI-PROJECT-22K07005
[Journal Article] Betulin Attenuates TGF-β1- and PGE<sub>2</sub>-Mediated Inhibition of NK Cell Activity to Suppress Tumor Progression and Metastasis in Mice2022
- Author(s)
  Ogasawara Masaru、Yamasaki-Yashiki Shino、Hamada Masahiro、Yamaguchi-Miyamoto Tomomi、Kawasuji Toru、Honda Hiroe、Yanagibashi Tsutomu、Ikutani Masashi、Watanabe Yasuharu、Fujimoto Ryota、Matsunaga Takayuki、Nakajima Noriyuki、Nagai Yoshinori、Takatsu Kiyoshi
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 45 Issue: 3 Pages: 339-353
- DOI
  10.1248/bpb.b21-00921
- NAID
  130008165815
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2022-03-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07076, KAKENHI-PROJECT-19K09019, KAKENHI-PROJECT-21K05466
[Journal Article] Bone marrow transplantation into Abcd1‐deficient mice: Distribution of donor derived‐cells and biological characterization of the brain of the recipient mice2021
- Author(s)
  Morita Masashi、Kaizawa Taro、Yoda Taiki、Oyama Takuro、Asakura Reina、Matsumoto Shun、Nagai Yoshinori、Watanabe Yasuharu、Watanabe Shiro、Kobayashi Hiroshi、Kawaguchi Kosuke、Yamamoto Seiji、Shimozawa Nobuyuki、So Takanori、Imanaka Tsuneo
- Journal Title
  
  Journal of Inherited Metabolic Disease
  
  Volume: 44 Issue: 3 Pages: 718-727
- DOI
  10.1002/jimd.12346
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09019, KAKENHI-PROJECT-17H04062, KAKENHI-PROJECT-18H02572, KAKENHI-PROJECT-19K08271
[Journal Article] Bidirectional Crosstalk Between Neutrophils and Adipocytes Promotes Adipose Tissue Inflammation2019
- Author(s)
  Watanabe Y, Nagai Y, Honda H, Okamoto N, Yanagibashi T, Ogasawara M, Yamamoto S, Imamura R, Takasaki I, Hara H, Sasahara M, Arita M, Hida S, Taniguchi S, Suda T, Takatsu K.
- Journal Title
  
  FASEB J.
  
  Volume: 33(11) Issue: 11 Pages: 11821-11835
- DOI
  10.1096/fj.201900477rr
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07365, KAKENHI-PROJECT-19K07076, KAKENHI-PROJECT-19K09019, KAKENHI-PROJECT-17H04062, KAKENHI-PROJECT-17K08389
[Journal Article] Advanced CUBIC tissue clearing for whole-organ cell profiling2019
- Author(s)
  Matsumoto Katsuhiko、Mitani Tomoki T.、Horiguchi Shuhei A.、Kaneshiro Junichi、Murakami Tatsuya C.、Mano Tomoyuki、Fujishima Hiroshi、Konno Ayumu、Watanabe Tomonobu M.、Hirai Hirokazu、Ueda Hiroki R.
- Journal Title
  
  Nature Protocols
  
  Volume: 14 Issue: 12 Pages: 3506-3537
- DOI
  10.1038/s41596-019-0240-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06899, KAKENHI-PLANNED-18H05409, KAKENHI-PROJECT-18H02521, KAKENHI-PROJECT-19J13071
[Journal Article] 肥満に伴う内臓脂肪組織炎症とメタボリック症候群における好中球の役割2018
- Author(s)
  渡邉康春、長井良憲、髙津聖志
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: ６９ Pages: 434-441
- Data Source
  KAKENHI-PROJECT-16K19532
[Journal Article] Funiculosin variants and phosphorylated derivatives promote innate immune responses via the Toll-like receptor 4/myeloid differentiation factor-2 complex2017
- Author(s)
  Okamoto N, Mizote K, Honda H, Saeki A, Watanabe Y, Yamaguchi-Miyamoto T, Fukui R, Tanimura N, Motoi Y, Akashi-Takamura S, Kato T, Fujishita S, Kimura T, Ohto U, Shimizu T, Hirokawa T, Miyake K, Fukase K, Fujimoto Y, Nagai Y, Takatsu K
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 292 Issue: 37 Pages: 15378-15394
- DOI
  10.1074/jbc.m117.791780
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19532, KAKENHI-PLANNED-15H05836, KAKENHI-PUBLICLY-17H05991, KAKENHI-PROJECT-16H01885, KAKENHI-PROJECT-17H02207, KAKENHI-PROJECT-15K07960, KAKENHI-PROJECT-15K08527, KAKENHI-PROJECT-16K19596, KAKENHI-PROJECT-15K09491
[Journal Article] Eplerenone prevented obesity-induced inflammasome activation and glucose intolerance2017
- Author(s)
  Wada T, Ishikawa A, Watanabe E, Nakamura Y, Aruga Y, Hasegawa H, Onogi Y, Honda H, Nagai Y, Takatsu K, Ishii Y, Sasahara M, Koya D, Tsuneki H, Sasaoka T
- Journal Title
  
  J Endocrinol.
  
  Volume: 235 Issue: 3 Pages: 179-191
- DOI
  10.1530/joe-17-0351
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15472, KAKENHI-PROJECT-17H04062, KAKENHI-PROJECT-15K07960, KAKENHI-PROJECT-15K08527
[Journal Article] A subset of cerebrovascular pericytes originates from mature macrophages in the very early phase of vascular development in CNS.2017
- Author(s)
  S. Yamamoto, M. Muramatsu, E. Azuma, M. Ikutani, Y. Nagai, H. Sagara, B.N. Koo, S. Kita, E. O’Donnell, T. Osawa, H. Takahashi, K.I. Takano, M. Dohmoto, M. Sugimori, I. Usui, Y. Watanabe, N. Hatakeyama, T. Iwamoto, I. Komuro, K. Takatsu, K. Tobe, S. Niida, N. Matsuda, M. Shibuya, M. Sasahara
- Journal Title
  
  Sci Rep
  
  Volume: 7：3855 Issue: 1 Pages: 1-16
- DOI
  10.1038/s41598-017-03994-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08565, KAKENHI-PROJECT-16K09777, KAKENHI-PROJECT-17K15622, KAKENHI-PROJECT-26710005, KAKENHI-PUBLICLY-16H01567, KAKENHI-PROJECT-17H04062, KAKENHI-PROJECT-15K08527, KAKENHI-PROJECT-16K14605
[Journal Article] Isoliquiritigenin attenuates adipose tissue inflammation in vitro and adipose tissue fibrosis through inhibition of innate immune responses in mice.2016
- Author(s)
  Watanabe Y, Nagai Y, Honda H, Okamoto N, Yamamoto S, Hamashima T, Ishii Y, Tanaka M, Suganami T, Sasahara M, Miyake, K, Takatsu K.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 23097-23097
- DOI
  10.1038/srep23097
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07960, KAKENHI-PROJECT-15K08527, KAKENHI-PROJECT-15K09423, KAKENHI-PUBLICLY-15H01371, KAKENHI-PROJECT-25870257, KAKENHI-PROJECT-25293093, KAKENHI-PROJECT-26460360
[Journal Article] HIF-1α in Myeloid Cells Promotes Adipose Tissue Remodeling Toward Insulin Resistance.2016
- Author(s)
  Takikawa A, Mahmood A, Nawaz A, Kado T, Okabe K, Yamamoto S, Arif A, Senda S, Tsuneyama K, Ikutani M, Watanabe Y, Igarashi Y, Nagai Y, Takatsu K, Koizumi K, Imura J, Goda N, Sasahara M, Matsumoto M, Saeki K, Nakagawa T, Fujisaka S, Usui I, Tobe K.
- Journal Title
  
  Diabetes
  
  Volume: 65(12) Issue: 12 Pages: 3649-3659
- DOI
  10.2337/db16-0012
- NAID
  40021380120
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293093, KAKENHI-PROJECT-26460360, KAKENHI-PROJECT-26461327, KAKENHI-PROJECT-15K08527, KAKENHI-PROJECT-16K09777, KAKENHI-PROJECT-16K19532
[Journal Article] Inflammatory responses increase secretion of MD-1 protein2016
- Author(s)
  Thomas Jennings R, Odkhuu E, Nakashima A, Morita N, Kobayashi T, Yamai I, Tanaka M, Suganami T, Haga S, Ozaki M, Watanabe Y, Nagai Y, Takatsu K, Kikuchi-Ueda T, Ichimonji I, Ogawa Y, Takagi H, Yamazaki T, Miyake K, Akashi-Takamura S
- Journal Title
  
  International Immunology
  
  Volume: 28 Issue: 10 Pages: 503-512
- DOI
  10.1093/intimm/dxw031
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08527, KAKENHI-PROJECT-15K09423, KAKENHI-PROJECT-15K09491, KAKENHI-PROJECT-16K19532
[Journal Article] Glycyrrhetinic acid inhibits contact hypersensitivity induced by trichophytin via dectin-12016
- Author(s)
  Tomoya Nakamura, Akiko Nishibu, Naoki Yoshida, Mitsue Yasoshima, Kazushi Anzawa, Yasuharu Watanabe, Yoshinori Nagai, Kiyoshi Takatsu, Kazuo Ogawa, Takashi Mochizuki
- Journal Title
  
  Experimental Dermatology
  
  Volume: 25 Issue: 4 Pages: 299-304
- DOI
  10.1111/exd.12931
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08527, KAKENHI-PROJECT-25870257
[Journal Article] Potential therapeutic natural products for the treatment of obesity-associated inflammation by targeting TLRs and inflammasomes2016
- Author(s)
  Nagai Y, Honda H, Watanabe Y, Takatsu K
- Journal Title
  
  Chronic Inflammation -Mechanisms and Regulation-
  
  Volume: なし Pages: 379-397
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08527
[Journal Article] 自然免疫系センサーによる慢性炎症制御とメタボリック症候群2015
- Author(s)
  長井良憲, 渡邉康春, 高津聖志
- Journal Title
  
  別冊BIO Clinica 慢性炎症と疾患「慢性炎症制御による加齢関係疾患治療の展望」
  
  Volume: 4 Pages: 67-72
- Data Source
  KAKENHI-PROJECT-15K08527
[Journal Article] Differential requirements of MyD88 And TRIF pathways in TLR4-mediated immune responses in murine B cells.2015
- Author(s)
  Yanagibashi T., Nagai Y., Watanabe Y., Ikutani M., Hirai Y., Takatsu K.
- Journal Title
  
  Immunology Letters
  
  Volume: 163 Issue: 1 Pages: 22-31
- DOI
  10.1016/j.imlet.2014.11.012
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390119, KAKENHI-PROJECT-24590577, KAKENHI-PUBLICLY-25126707, KAKENHI-PROJECT-25870257
[Journal Article] Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation.2014
- Author(s)
  Honda H., Nagai Y., Matsunaga T., Okamoto N., Watanabe Y., Tsuneyama K., Hayashi H., Fujii I., Ikutani M., Hirai Y., Muraguchi A., Takatsu K.
- Journal Title
  
  Journal of Leukocyte Biology
  
  Volume: 96 Issue: 6 Pages: 1087-1100
- DOI
  10.1189/jlb.3a0114-005rr
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390119, KAKENHI-PROJECT-24390181, KAKENHI-PROJECT-24590577, KAKENHI-PUBLICLY-25126707, KAKENHI-PROJECT-25670175, KAKENHI-PROJECT-25870257
[Journal Article] Evaluating the role of conserved amino acids in bacterial O-oligosaccharyltransferases by in vivo, in vitro and limited proteolysis assays.2014
- Author(s)
  Matias A Musumeci, Amirreza Faridmoayer, Yasuharu Watanabe, Mario F Feldman.
- Journal Title
  
  Glycobiology
  
  Volume: 24(1) Issue: 1 Pages: 39-50
- DOI
  10.1093/glycob/cwt087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25870257
[Journal Article] Activation and regulation of the pattern recognition receptors in obesity-induced adipose tissue inflammation and insulin resistance2013
- Author(s)
  Yasuharu Watanabe, Yoshinori Nagai, Kiyoshi Takatsu
- Journal Title
  
  Nutrients
  
  Volume: 5 Issue: 9 Pages: 3757-3778
- DOI
  10.3390/nu5093757
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24117708, KAKENHI-PROJECT-24390119, KAKENHI-PROJECT-24590577, KAKENHI-PUBLICLY-25126707, KAKENHI-PROJECT-25870257
[Journal Article] The TLR family protein RP105/MD-1 complex: a new player in obesity and adipose tissue inflammation2013
- Author(s)
  Yoshinori Nagai, Yasuharu Watanabe, Kiyoshi Takatsu
- Journal Title
  
  Adipocyte
  
  Volume: 2 Issue: 2 Pages: 61-66
- DOI
  10.4161/adip.22929
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24117708, KAKENHI-PROJECT-24390119, KAKENHI-PROJECT-24590577, KAKENHI-PUBLICLY-25126707, KAKENHI-PROJECT-25870257
[Presentation] イソリクイリチゲニンによる腸内細菌叢の変動を介したメタボリックシンドロームの改善2022
- Author(s)
  石橋璃子, 古澤之裕, 本田裕恵, 渡邉康春, 藤坂志帆, 戸邉一之, 高津聖志, 栗原新, 田渕圭章, 長井良憲
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K09019
[Presentation] Crosstalk between neutrophils and adipocytes exacerbates adipose tissue inflammation in progression of type 2 diabetes2021
- Author(s)
  渡邉康春
- Organizer
  第6回富山バーゼルジョインシンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09019
[Presentation] Bidirectional crosstalk between neutrophils and adipocytes promotes adipose tissue inflammation2020
- Author(s)
  Watanabe Y., Nagai Y.,and Takatsu K
- Organizer
  The 104th Annual Meeting of The American Association of Immunologists
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09019
[Presentation] 好中球と脂肪細胞の相互作用は内臓脂肪組織の炎症を誘導する2019
- Author(s)
  渡邉康春、長井良憲、髙津聖志
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K09019
[Presentation] TLRのアダプター分子TRIFを介した摂食調節異常・視床下部炎症の解析2019
- Author(s)
  渡邉康春、長井良憲、髙津聖志
- Organizer
  第40回日本炎症・再生医学会
- Data Source
  KAKENHI-PROJECT-19K09019
[Presentation] 内臓脂肪組織炎症における好中球と脂肪細胞のクロストーク2019
- Author(s)
  長井良憲、渡邉康春、髙津聖志
- Organizer
  第40回日本炎症・再生医学会
- Data Source
  KAKENHI-PROJECT-19K09019
[Presentation] 遊離脂肪酸を起点とした好中球と脂肪細胞との相互作用は、IL-1β産生とマクロファージの内臓脂肪組織浸潤に関与する2018
- Author(s)
  渡邉康春, 長井良憲, 高津聖志
- Organizer
  第39回日本炎症・再生医学会
- Data Source
  KAKENHI-PROJECT-16K19532
[Presentation] Crosstalk between neutrophils and adipocytes exacerbates adipose tissue inflammation in progression of type 2 diabetes2018
- Author(s)
  渡邉康春, 長井良憲, 高津聖志
- Organizer
  第5回富山・バーゼル医薬品研究開発シンポジウム
- Data Source
  KAKENHI-PROJECT-16K19532
[Presentation] The exploration of natural products as inhibitors of obesity-associated adipose tissue inflammation2018
- Author(s)
  渡邉康春
- Organizer
  The Virtual University of Pakistan:International Conference on "Therapeutic Importance of Traditional medicine”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19532
[Presentation] 糖尿病モデルマウスの内臓脂肪組織に対するイソリクイリチゲニンの抗炎症・抗線維化作用の解析2018
- Author(s)
  本田裕恵, 渡邉康春, 長井良憲, 松永孝之, 岡本直樹, 平井嘉勝, 高津聖志
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K08527
[Presentation] 糖尿病モデルマウスの内臓脂肪組織に対するイソリクイリチゲニンの抗炎症・抗線維化作用の解析2018
- Author(s)
  本田裕恵, 渡邉康春, 長井良憲, 松永孝之, 岡本直樹, 平井嘉勝, 高津聖志
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K19532
[Presentation] The interaction of neutrophils with adipocytes plays a key role in the infiltration of macrophage into the adipose tissue2017
- Author(s)
  Watanabe Yasuharu, Nagai Yoshinori, Takatsu Kiyoshi
- Organizer
  第46回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-16K19532
[Presentation] The interaction of neutrophils with adipocytes plays a key role in the infiltration of macrophage into the adipose tissue2017
- Author(s)
  Yasuharu Watanabe, Yoshinori Nagai, Kiyoshi Takatsu
- Organizer
  第46回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-15K08527
[Presentation] 甘草成分イソリクイリチゲニンはNLRP3インフラマソーム活性化を阻害し、2型糖尿病の慢性炎症を改善する2016
- Author(s)
  7.本田裕恵, 長井良憲, 松永孝之, 岡本直樹, 渡邉康春, 常山幸一, 林宏明, 藤井勲, 平井嘉勝, 高津聖志
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-29
- Data Source
  KAKENHI-PROJECT-25870257
[Presentation] Adipose tissue neutrophils are primed by the interaction with adipocytes2016
- Author(s)
  Watanabe Yasuharu, Nagai Yoshinori, Takatsu Kiyoshi
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター・ラグナガーデンホテル(沖縄県宜野湾市)
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K19532
[Presentation] TLRのアダプター分子TRIFを介した視床下部炎症と摂食制御異常の解析2016
- Author(s)
  渡邉康春、長井良憲、高津聖志
- Organizer
  第37回日本炎症・再生医学会
- Place of Presentation
  京都市勧業館　みやこめっせ(京都府京都市)
- Year and Date
  2016-06-16
- Data Source
  KAKENHI-PROJECT-16K19532
[Presentation] 天然薬物イソリクイリチゲニンは自然免疫系に作用し、内臓脂肪組織の線維化を抑制する2016
- Author(s)
  渡邉康春、長井良憲、本田裕恵、高津聖志
- Organizer
  第37回日本肥満学会
- Place of Presentation
  東京ファッションタウン(東京都江東区）
- Year and Date
  2016-10-07
- Data Source
  KAKENHI-PROJECT-16K19532
[Presentation] 甘草成分イソリクイリチゲニンは内臓脂肪組織の炎症・線維化を抑制する2016
- Author(s)
  本田裕恵、渡邉康春、長井良憲、松永孝之、岡本直樹、平井嘉勝、高津聖志
- Organizer
  日本生薬学会第63回年会
- Place of Presentation
  富山国際会議場(富山県富山市)
- Year and Date
  2016-09-24
- Data Source
  KAKENHI-PROJECT-16K19532
[Presentation] 骨髄移植による副腎白質ジストロフィー発症抑制機構の解明：レシピエントマウスの生化学的解析2016
- Author(s)
  大山拓郎、冨田勇、螺澤太郎、松本隼、守田雅志、渡辺志朗、渡邉康春、長井良憲、高津聖志、山本誠二、石井陽子、笹原正清、今中常雄
- Organizer
  第128回薬学会北陸支部会
- Place of Presentation
  北陸大学(石川県金沢市）
- Data Source
  KAKENHI-PROJECT-16K19532
[Presentation] TLRのアダプター分子TRIFを介した視床下部炎症と摂食制御異常の解析2016
- Author(s)
  渡邉康春, 長井良憲, 高津聖志
- Organizer
  第37回日本炎症・再生医学会
- Place of Presentation
  京都市勧業館みやこめっせ
- Year and Date
  2016-06-16
- Data Source
  KAKENHI-PROJECT-15K08527
[Presentation] 甘草成分イソリクイリチゲニンはNLRP3インフラマソーム活性化を阻害し、2型糖尿病の慢性炎症を改善する2016
- Author(s)
  本田裕恵, 長井良憲, 松永孝之, 岡本直樹, 渡邉康春, 常山幸一, 林宏明, 藤井勲, 平井嘉勝, 高津聖志
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K08527
[Presentation] 甘草成分イソリクイリチゲニンは内臓脂肪組織の炎症・線維化を抑制する2016
- Author(s)
  本田裕恵, 渡邉康春, 長井良憲, 松永孝之, 岡本直樹, 平井嘉勝, 高津聖志
- Organizer
  日本生薬学会第63回年会
- Place of Presentation
  富山国際会議場
- Year and Date
  2016-09-24
- Data Source
  KAKENHI-PROJECT-15K08527
[Presentation] 天然薬物イソリクイリチゲニンは自然免疫系に作用し、内臓脂肪組織の線維化を抑制する2016
- Author(s)
  渡邉康春, 長井良憲, 本田裕恵, 高津聖志
- Organizer
  第37回日本肥満学会
- Place of Presentation
  東京ファッションタウン
- Year and Date
  2016-10-07
- Data Source
  KAKENHI-PROJECT-15K08527
[Presentation] Adipose tissue neutrophils are primed by the interaction with adipocytes2016
- Author(s)
  Yasuharu Watanabe, Yoshinori Nagai, Kiyoshi Takatsu
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-15K08527
[Presentation] 遊離脂肪酸誘発性の内臓脂肪組織炎症モデルにおける好中球とIL-1βの機能解析2015
- Author(s)
  長井良憲, 渡邉康春, 高津聖志
- Organizer
  第36回日本炎症・再生医学会
- Place of Presentation
  東京
- Year and Date
  2015-07-21
- Data Source
  KAKENHI-PROJECT-25870257
[Presentation] 遊離脂肪酸誘発性の内臓脂肪組織炎症における好中球の機能解析2015
- Author(s)
  渡邉康春, 長井良憲, 高津聖志
- Organizer
  第36回日本肥満学会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-03
- Data Source
  KAKENHI-PROJECT-25870257
[Presentation] 遊離脂肪酸誘発性の内臓脂肪組織炎症モデルにおける好中球とIL-1βの機能解析2015
- Author(s)
  長井良憲, 渡邉康春, 高津聖志
- Organizer
  第36回日本炎症・再生医学会
- Place of Presentation
  虎ノ門ヒルズフォーラム
- Year and Date
  2015-07-21
- Data Source
  KAKENHI-PROJECT-15K08527
[Presentation] 遊離脂肪酸誘発性の内臓脂肪組織炎症における好中球の機能解析2015
- Author(s)
  渡邉康春, 長井良憲, 高津聖志
- Organizer
  第36回日本肥満学会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-15K08527
[Presentation] Accumulation of and increased IL-1β production by neutrophils in adipose tissue: roles of free fatty acid and leukotriene B42015
- Author(s)
  Watanabe Y, Nagai Y, Takatsu K
- Organizer
  第44回日本免疫学会学術集会,
- Place of Presentation
  札幌
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-25870257
[Presentation] Accumulation of and increased IL-1β production by neutrophils in adipose tissue: roles of free fatty acid and leukotriene B42015
- Author(s)
  Yasuharu Watanabe, Yoshinori Nagai Y, Kiyoshi Takatsu
- Organizer
  第44回日本免疫学会学術集会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K08527
[Presentation] 遊離脂肪酸誘発性の内臓脂肪組織炎症における好中球とIL-1βの機能解析2014
- Author(s)
  長井良憲, 渡邉康春, 高津聖志
- Organizer
  第35回日本肥満学会
- Place of Presentation
  宮崎
- Year and Date
  2014-10-24
- Data Source
  KAKENHI-PROJECT-25870257
[Presentation] メタボリック症候群における慢性炎症を制御する自然免疫シグナルの解析2013
- Author(s)
  長井良憲, 渡邉康春, 本田裕恵, 戸邉一之, 高津聖志
- Organizer
  第34回日本肥満学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25870257
[Presentation] Regulatory mechanisms of Radioprotective 105/MD-1 expression in inflammatory macrophages in the adipose tissue2013
- Author(s)
  Yasuharu Watanabe, Yoshinori Nagai, Kiyoshi Takatsu.
- Organizer
  第78回日本インターフェロン・サイトカイン学会, 第21回マクロファージ分子細胞生物学国際シンポジウム合同学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25870257
[Presentation] β3-adrenergic receptor-mediated lipolysis of adipocytes induces accumulation of large number of neutrophils and pro-inflammatory responses in mouse adipose tissue2013
- Author(s)
  Yasuharu Watanabe, Yoshinori Nagai, Koichi Tsuneyama, Kiyoshi Takatsu.
- Organizer
  第42回日本免疫学会学術集会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-25870257
[Presentation] Adipocyte-derived free fatty acids trigger IL-1beta production by neutrophils in mouse adipose tissue
- Author(s)
  Yasuharu Watanabe, Yoshinori Nagai, Koichi Tsuneyama, Kiyoshi Takatsu
- Organizer
  第43回日本免疫学会学術集会
- Place of Presentation
  京都
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-25870257

1. NAGAI Yoshinori (30431761)

# of Collaborated Projects: 2 results

# of Collaborated Products: 32 results
2. Konno Ayumu (40509048)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. 古澤之裕 (80632306)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 田渕圭章 (20322109)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. IKUTANI Masashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. HONDA Hiroe

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 高津聖志

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. 高崎一朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 古家大祐

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 山本誠士

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 笹原正清

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 柳橋努

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 喜多紗斗美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yasuharu Watanabe 渡邉 康春

WATANABE Yasuharu 渡邉 康春

Research Projects

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Co-Researchers

Role of butyrate-targeted HDAC isozyme in the regulation of intestinal inflammation

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視床下部炎症を誘導する自然免疫シグナル経路の解析：摂食調節異常機構の解明Principal Investigator

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Development of a technique that allows repeatable gene transfer into the brain using AAV vectors

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Functional analysis of TRIF-mediated innate immune signaling in hypothalamic inflammation-induced dysregulation of food intakePrincipal Investigator

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Free fatty acids-mediated dynamic changes of neutrophils induce adipose tissue inflammationPrincipal Investigator

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Elucidation of the mechanism of the innate immune signal that induces hypothalamic inflammation and feeding dysfunction

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Elucidation of regulation mechanisms of RP105/MD-1 in obesity-induced chronic inflammationPrincipal Investigator

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[Book] Biological activities and action mechanisms of licorice ingredients2017

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[Book] Chronic Inflammation: Mechanisms and Regulation2016

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[Book] 自然免疫系センサーによる慢性炎症制御とメタボリック症候群2015

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[Journal Article] Roles of Macrophages in Advanced Liver Fibrosis, Identified Using a Newly Established Mouse Model of Diet-Induced Non-Alcoholic Steatohepatitis2022

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[Journal Article] Isoliquiritigenin Attenuates Adipose Tissue Inflammation and Metabolic Syndrome by Modifying Gut Bacteria Composition in Mice2022

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[Journal Article] Betulin Attenuates TGF-β1- and PGE<sub>2</sub>-Mediated Inhibition of NK Cell Activity to Suppress Tumor Progression and Metastasis in Mice2022

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Yasuharu Watanabe 渡邉康春

WATANABE Yasuharu 渡邉康春