Kobayashi Akiko 小林亜希子

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KOBAYASHI Akiko 小林亜希子

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Researcher Number	80649046
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 特定准教授
Affiliation (based on the past Project Information) *help	2022 – 2025: 京都大学, 医学研究科, 特定准教授 2017 – 2021: 京都大学, 医学研究科, 助教 2018: 京都大学, 医学研究科, 特定助教 2016: 京都大学, 医学研究科, 特定助教
Review Section/Research Field	Principal Investigator Basic Section 49010:Pathological biochemistry-related / Basic Section 51030:Pathophysiologic neuroscience-related / Chemical biology Except Principal Investigator Basic Section 49010:Pathological biochemistry-related
Keywords	Principal Investigator 神経炎症 / アストログリア / アストロサイト / 化合物探索 / 神経発達 / シーズ探索 / ダウン症 / 神経新生 Except Principal Investigator 伝搬 / アルツハイマー病 / 異常凝集体 / 神経細胞死 / 神経変性疾患

Aβ凝集体の広域伝播とtau病態発症の分子機序の解明と早期治療法の開発
- Principal Investigator
  
  星美奈子
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Foundation for Biomedical Research and Innovation at Kobe
アストロサイト形質転換の分子機序解明と創薬標的の探索Principal Investigator
- Principal Investigator
  
  小林亜希子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Kyoto University
Identification of the mechanism inducing reactive astrocyte in neuroinflammatory condition as a therapeutic target.Principal Investigator
- Principal Investigator
  
  Kobayashi Akiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Kyoto University
Development of neurogenesis inducer for neurodegenerative disordersPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Akiko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical biology
- Research Institution
  Kyoto University

All 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation Patent

[Journal Article] ダウン症におけるDYRK1Aの役割と分子標的薬の可能性2020
- Author(s)
  小林亜希子、萩原正敏
- Journal Title
  
  Clinical Neuroscience
  
  Volume: 38 Pages: 1570-1572
- Data Source
  KAKENHI-PROJECT-19K07821
[Journal Article] Therapeutics potentiating microglial p21-Nrf2 axis can rescue neurodegeneration caused by neuroinflammation2020
- Author(s)
  A. Nakano-Kobayashi1,*, A. Fukumoto2, A. Morizane2, D. T. Nguyen3, T. M. Le3, K. Hashida3, T. Hosoya4, R. Takahashi5,J. Takahashi2, O. Hori3 and M. Hagiwara1
- Journal Title
  
  Science Advances
  
  Volume: 6 Issue: 46 Pages: 1-12
- DOI
  10.1126/sciadv.abc1428
- NAID
  120006898186
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07821, KAKENHI-PROJECT-18H02912, KAKENHI-PROJECT-18K06500
[Journal Article] DYRK1A and cognition: A lifelong relationship2019
- Author(s)
  Maria L.ArbonesaAuroreThomazeaubAkikoNakano-KobayashicMasatoshiHagiwaracJean M.Delabar
- Journal Title
  
  Pharmacology & Therapeutics
  
  Volume: 194 Pages: 199-221
- DOI
  10.1016/j.pharmthera.2018.09.010
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01932
[Journal Article] Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice2017
- Author(s)
  Akiko Nakano-Kobayashi, Tomonari Awaya, Isao Kii, Yuto Sumida, Yukiko Okuno, Suguru Yoshida, Tomoe Sumida, Haruhisa Inoue, Takamitsu Hosoya and Masatoshi Hagiwara
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of america
  
  Volume: 114 Issue: 38 Pages: 10268-10273
- DOI
  10.1073/pnas.1704143114
- NAID
  130007900113
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K01932, KAKENHI-PROJECT-15H05721, KAKENHI-PROJECT-16H05926, KAKENHI-PROJECT-21249013, KAKENHI-PROJECT-16K17907
[Patent] COMPOSITION FOR ACTIVATING NEUROGENESIS2022
- Inventor(s)
  Masatoshi Hagiwara, Akiko Kobayashi
- Industrial Property Rights Holder
  Kyoto Universiy
- Industrial Property Rights Type
  特許
- Acquisition Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-16K01932
[Patent] COMPOSITION FOR ACTIVATING NEUROGENESIS2022
- Inventor(s)
  小林亜希子、萩原正敏
- Industrial Property Rights Holder
  小林亜希子、萩原正敏
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Acquisition Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-23K24092
[Patent] 神経新生を活性化するための組成物2022
- Inventor(s)
  小林亜希子、萩原正敏
- Industrial Property Rights Holder
  小林亜希子、萩原正敏
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Acquisition Date
  2022
- Data Source
  KAKENHI-PROJECT-23K24092
[Patent] COMPOSITION FOR ACTIVATING NEUROGENESIS2022
- Inventor(s)
  Masatoshi Hagiwara, Akiko Kobayashi
- Industrial Property Rights Holder
  Kyoto Universiy
- Industrial Property Rights Type
  特許
- Acquisition Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-16K01932
[Patent] 神経新生に関する化合物及び医薬組成物2022
- Inventor(s)
  萩原正敏、小林亜希子
- Industrial Property Rights Holder
  国立大学法人京都大学
- Industrial Property Rights Type
  特許
- Acquisition Date
  2022
- Data Source
  KAKENHI-PROJECT-16K01932
[Patent] COMPOSITION FOR ACTIVATING NEUROGENESIS2022
- Inventor(s)
  Masatoshi Hagiwara, Akiko Kobayashi
- Industrial Property Rights Holder
  Kyoto Universiy
- Industrial Property Rights Type
  特許
- Acquisition Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-16K01932
[Patent] COMPOSITION FOR ACTIVATING NEUROGENESIS2022
- Inventor(s)
  Masatoshi Hagiwara, Akiko Kobayashi
- Industrial Property Rights Holder
  Kyoto Universiy
- Industrial Property Rights Type
  特許
- Acquisition Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-16K01932
[Patent] 神経炎症の抑制、そのための組成物及び方法2020
- Inventor(s)
  小林亜希子、萩原正敏
- Industrial Property Rights Holder
  小林亜希子、萩原正敏
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-066150
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19K07821
[Patent] 神経新生を活性化するための組成物2017
- Inventor(s)
  萩原正敏　小林亜希子　細谷孝光　吉田優　隅田有人
- Industrial Property Rights Holder
  萩原正敏　小林亜希子　細谷孝光　吉田優　隅田有人
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Overseas
- Data Source
  KAKENHI-PROJECT-16K01932
[Presentation] Therapeutics potentiating microglial p21-Nrf2 axis can rescue neurodegeneration caused by neuroinflammation 神経炎症を標的としたグリア機能制御機構の解明2021
- Author(s)
  小林亜希子
- Organizer
  第94回日本生化学大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07821
[Presentation] 神経新生からダウン症へのアプローチ2020
- Author(s)
  小林亜希子
- Organizer
  日本ダウン症分科会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07821
[Presentation] Therapeutics potentiating microglial p21-Nrf2 axis can rescue neurodegeneration caused by neuroinflammation2020
- Author(s)
  小林亜希子
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K07821
[Presentation] Prenatal neurogenesis induction therapy normalizes brain structure and functions in Down syndrome mice2020
- Author(s)
  小林亜希子
- Organizer
  第13回成体脳ニューロジェネシス研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07821
[Presentation] Prenatal neurogenesis induction therapy normalizes brain structure and functions in Down syndrome mice2019
- Author(s)
  小林亜希子
- Organizer
  第42回分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07821
[Presentation] Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice2018
- Author(s)
  Akiko Nakano-Kobayashi,　Tomonari Awaya, Isao Kii, Yuto Sumida2), Yukiko Okuno, Keiko Wanezaki, Suguru Yoshida, Tomoe Sumida Haruhisa Inoue, Takamitsu Hosoya and Masatoshi Hagiwara
- Organizer
  ISDN2018 (22nd Biennial Meeeting of the International Society for Developmental Neuroscience)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01932
[Presentation] Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice2018
- Author(s)
  Akiko Nakano-Kobayashi,　Tomonari Awaya, Isao Kii, Yuto Sumida2), Yukiko Okuno, Keiko Wanezaki, Suguru Yoshida, Tomoe Sumida Haruhisa Inoue, Takamitsu Hosoya and Masatoshi Hagiwara
- Organizer
  The 41st Annual Meeting of the Japan Neuroscience Society
- Data Source
  KAKENHI-PROJECT-16K01932
[Presentation] Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice2018
- Author(s)
  Akiko Nakano-Kobayashi,　Tomonari Awaya, Isao Kii, Yuto Sumida2), Yukiko Okuno, Keiko Wanezaki, Suguru Yoshida, Tomoe Sumida Haruhisa Inoue, Takamitsu Hosoya and Masatoshi Hagiwara
- Organizer
  WCP2018/18 th World Congress of Basicand Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01932
[Presentation] Prenatal neurogenesis induction therapy normalizes brain structure and functions in Down syndrome mice2017
- Author(s)
  小林亜希子、粟屋智就、喜井勲、隅田有人、奥野友紀子、和根崎圭子、吉田優、隅田ともえ、井上治久、細谷孝充、萩原正敏
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-16K01932
[Presentation] Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice2017
- Author(s)
  Akiko Nakano-Kobayashi and Masatoshi Hagiwara
- Organizer
  Dyrk1A Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01932
[Presentation] Repression of DYRK1A restores impaired cortical development and abnormal learning behavior of Down syndrome mice2017
- Author(s)
  小林亜希子
- Organizer
  DYRK1A Conference
- Place of Presentation
  フランス
- Year and Date
  2017-03-29
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01932
[Presentation] ダウン症モデルでの神経新生の低下を改善するDYRK1A阻害剤の創薬2016
- Author(s)
  小林亜希子
- Organizer
  日本ケミカルバイオロジー学会第11回年会
- Place of Presentation
  京都
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-16K01932

1. Canela Andres (90837585)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 星美奈子 (30374010)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 笹原智也 (30735345)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 豊島近 (70172210)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kobayashi Akiko 小林 亜希子

KOBAYASHI Akiko 小林 亜希子

Research Projects

Research Products

Co-Researchers

Aβ凝集体の広域伝播とtau病態発症の分子機序の解明と早期治療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

アストロサイト形質転換の分子機序解明と創薬標的の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of the mechanism inducing reactive astrocyte in neuroinflammatory condition as a therapeutic target.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of neurogenesis inducer for neurodegenerative disordersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] ダウン症におけるDYRK1Aの役割と分子標的薬の可能性2020

Author(s)

Journal Title

Data Source

[Journal Article] Therapeutics potentiating microglial p21-Nrf2 axis can rescue neurodegeneration caused by neuroinflammation2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] DYRK1A and cognition: A lifelong relationship2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Patent] COMPOSITION FOR ACTIVATING NEUROGENESIS2022

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Acquisition Date

Data Source

[Patent] COMPOSITION FOR ACTIVATING NEUROGENESIS2022

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Acquisition Date

Data Source

[Patent] 神経新生を活性化するための組成物2022

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Acquisition Date

Data Source

[Patent] COMPOSITION FOR ACTIVATING NEUROGENESIS2022

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Acquisition Date

Data Source

[Patent] 神経新生に関する化合物及び医薬組成物2022

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Kobayashi Akiko 小林亜希子

KOBAYASHI Akiko 小林亜希子