Sakaguchi Reiko 坂口怜子

Researcher Number	80723197
Other IDs
Affiliation (Current)	2025: 産業医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2021 – 2024: 産業医科大学, 医学部, 講師 2017 – 2020: 京都大学, 高等研究院, 特定助教 2019: 京都大学, 工学研究科, 助教 2016: 京都大学, 物質－細胞統合システム拠点, 特定助教 2015: 京都大学, 物質-細胞統合システム拠点, 特定助教 2014 – 2015: 京都大学, 物質-細胞統合システム拠点, 助教
Review Section/Research Field	Principal Investigator Basic Section 37010:Bio-related chemistry / Bio-related chemistry / Chemical biology Except Principal Investigator Basic Section 34010:Inorganic/coordination chemistry-related / Applied physics and engineering and related fields
Keywords	Principal Investigator シグナル伝達 / タンパク質工学 / イオンチャネル / ケミカルバイオロジー / 創薬 / 神経変性疾患 / タンパク質品質管理 / 転移RNA / ライブイメージング / 細胞内温度計測 … More / イメージング / バイオセンサー / 温度生物学 / 熱生産 / 温度センサー / 生物・生体工学 / 神経科学 / 多孔性材料 / 機能性材料 / 一酸化窒素 / 神経分化 / ガスバイオロジー / 細胞応答制御 / 単一細胞測定 / 蛍光イメージング / 分子認識 / 生体関連化学 … More Except Principal Investigator 多孔体 / 電流計測 / 金属錯体 / イオンチャンネル / イオンチャネル / ペプチド / 酵素 / 金属錯体多面体 / 人工イオンチャネル / 生体機能制御 / 細胞制御 / 高強度THz / 非線形光学 / iPS細胞 / 再生医療 / 細胞機能制御 / 分化誘導 / 蛍光プローブ / ライブセルイメージング / 非線形分光 / 高強度テラヘルツ Less

光照射による一酸化窒素合成酵素の機能模倣システムの構築Principal Investigator
- Principal Investigator
  
  坂口怜子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  University of Occupational and Environmental Health, Japan
トランスファーRNA修飾酵素によるタンパク質品質管理機構の解明Principal Investigator
- Principal Investigator
  
  坂口怜子
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  University of Occupational and Environmental Health, Japan
蛍光性タンパク質温度センサーを用いた生体内温度分布の意義の解明Principal Investigator
- Principal Investigator
  
  坂口怜子
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  Kyoto University
Stimuli-Responsive Synthetic Ion Channels Based on Metal-Organic Polyhedra
- Principal Investigator
  
  Furukawa Shuhei
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 34010:Inorganic/coordination chemistry-related
- Research Institution
  Kyoto University
Non-contact and non-invasive manipulation of biological functionalities using all-optical method
- Principal Investigator
  
  Hirori Hideki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Research Field
  
  Applied physics and engineering and related fields
- Research Institution
  Kyoto University
Regulation of cell responses by light controled signal releasing materialPrincipal Investigator
- Principal Investigator
  
  Sakaguchi Reiko
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bio-related chemistry
- Research Institution
  Kyoto University
Development of fluorescent sensors to quantitatively detect signal molecules in single cellsPrincipal Investigator
- Principal Investigator
  
  Sakaguchi Reiko
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical biology
- Research Institution
  Kyoto University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014

All Journal Article Presentation Book Patent

[Book] Detection of Inositol Phosphates by Split PH Domains. In: Miller G. (eds) Inositol Phosphates. Methods in Molecular Biology2020
- Author(s)
  Sakaguchi R., Tajima S., Mori Y., Morii T.
- Total Pages
  11
- Publisher
  Humana, New York, NY
- ISBN
  9781071601679
- Data Source
  KAKENHI-PROJECT-16K05843
[Journal Article] A two-step screening to optimize the signal response of an auto-fluorescent protein-based biosensor2022
- Author(s)
  Tajima Shunsuke、Nakata Eiji、Sakaguchi Reiko、Saimura Masayuki、Mori Yasuo、Morii Takashi
- Journal Title
  
  RSC Advances
  
  Volume: 12 Issue: 24 Pages: 15407-15419
- DOI
  10.1039/d2ra02226e
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K05272
[Journal Article] Cell-autonomous control of intracellular temperature by unsaturation of phospholipid acyl chains2022
- Author(s)
  Murakami A., Nagao K., Sakaguchi R., Kida K., Hara Y., Mori Y., Okabe K., Harada Y., Umeda M.
- Journal Title
  
  Cell Reports
  
  Volume: 38 Issue: 11 Pages: 110487-110487
- DOI
  10.1016/j.celrep.2022.110487
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05433, KAKENHI-PLANNED-20H05785, KAKENHI-PROJECT-20J01234, KAKENHI-PROJECT-21K05272, KAKENHI-PROJECT-21K05391, KAKENHI-PROJECT-20K21388
[Journal Article] Photoactive carbon monoxide-releasing coordination polymer particles2022
- Author(s)
  Carne-Sanchez Arnau、Ikemura Shuya、Sakaguchi Reiko、Craig Gavin A.、Furukawa Shuhei
- Journal Title
  
  Chemical Communications
  
  Volume: 58 Issue: 71 Pages: 9894-9897
- DOI
  10.1039/d2cc03907a
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05272
[Journal Article] Critical contributions of pre-S1 shoulder and distal TRP box in DAG-activated TRPC6 channel by PIP2 regulation2022
- Author(s)
  Mori Masayuki X.、Okada Ryo、Sakaguchi Reiko、Hase Hideharu、Imai Yuko、Polat Onur K.、Itoh Satoru G.、Okumura Hisashi、Mori Yasuo、Okamura Yasushi、Inoue Ryuji
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 1-13
- DOI
  10.1038/s41598-022-14766-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07269, KAKENHI-PROJECT-21K05272, KAKENHI-PLANNED-20H05791, KAKENHI-PROJECT-23K24066, KAKENHI-PROJECT-23K24078
[Journal Article] Osteoclasts adapt to physioxia perturbation through DNA demethylation2021
- Author(s)
  Nishikawa Keizo、Seno Shigeto、Yoshihara Toshitada、Narazaki Ayako、Sugiura Yuki、Shimizu Reito、Kikuta Junichi、Sakaguchi Reiko、Suzuki Norio、Takeda Norihiko、Semba Hiroaki、Yamamoto Masamichi、et al
- Journal Title
  
  EMBO reports
  
  Volume: 22 Issue: 12 Pages: 53035-53035
- DOI
  10.15252/embr.202153035
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22513, KAKENHI-PLANNED-20H05901, KAKENHI-PROJECT-19H05657, KAKENHI-PROJECT-19H03561, KAKENHI-PROJECT-21H02716, KAKENHI-PROJECT-20K09474, KAKENHI-PROJECT-21K05272, KAKENHI-PROJECT-20K20394, KAKENHI-PROJECT-18H04122, KAKENHI-PROJECT-23K21372
[Journal Article] Functionally deficient TRPV6 variants contribute to hereditary and familial chronic pancreatitis2021
- Author(s)
  Hamada S, Masson E, Chen JM, Sakaguchi R, Rebours V, Buscail L, Matsumoto R, Tanaka Y, Kikuta K, Kataoka F, Sasaki A, Le Rhun M, Audin H, Lachaux A, Caumont B, Lorenzo D, Billiemaz K, Besnard R, Koch S, Lamireau T, De Koninck X; GREPAN Study Group, Genin E, Cooper DN, Mori Y, Masamune A, Ferec C
- Journal Title
  
  Human Mutation
  
  Volume: 43 Issue: 2 Pages: 228-239
- DOI
  10.1002/humu.24315
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05272
[Journal Article] Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca2+ mobilization and the inflammatory activity of dendritic cells2021
- Author(s)
  Marongiu Laura、Morii Takashi、Granucci Francesca, et al
- Journal Title
  
  Science Signaling
  
  Volume: 14 Issue: 676
- DOI
  10.1126/scisignal.aaz2120
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01213, KAKENHI-PROJECT-21K05272
[Journal Article] Variants That Affect Function of Calcium Channel TRPV6 Are Associated With Early-Onset Chronic Pancreatitis.2020
- Author(s)
  Masamune A, Kotani H, Sorgel FL, Chen JM, Hamada S, Sakaguchi R, Masson E, Nakano E, et al.
- Journal Title
  
  Gastroenterology
  
  Volume: - Issue: 6 Pages: 1626-1641
- DOI
  10.1053/j.gastro.2020.01.005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17450, KAKENHI-PUBLICLY-18H04695, KAKENHI-PUBLICLY-18H04795, KAKENHI-PROJECT-17H04035, KAKENHI-PROJECT-16K05843, KAKENHI-PROJECT-18K19281, KAKENHI-PROJECT-19H03417, KAKENHI-PROJECT-18K06872
[Journal Article] Fluorescence detection of the nitric oxide-induced structural change at the putative nitric oxide sensing segment of TRPC5.2020
- Author(s)
  Tajima S, Nakata E, Sakaguchi R, Saimura M, Mori Y, Morii T.
- Journal Title
  
  Bioorg Med Chem
  
  Volume: 28 Pages: 115430-115430
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K05843
[Journal Article] Fluorescence detection of the nitric oxide-induced structural change at the putative nitric oxide sensing segment of TRPC5.2020
- Author(s)
  Tajima S, Nakata E, Sakaguchi R, Saimura M, Mori Y, Morii T.
- Journal Title
  
  Bioorg Med Chem
  
  Volume: 28 Pages: 115430-115430
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-18H04695
[Journal Article] TRPM7 channels mediate spontaneous Ca2+ fluctuations in growth plate chondrocytes that promote bone development.2019
- Author(s)
  Qian N, Ichimura A, Takei D, Sakaguchi R, Kitani A, Nagaoka R, Tomizawa M, Miyazaki Y, Miyachi H, Numata T, Kakizawa S, Nishi M, Mori Y, Takeshima H.
- Journal Title
  
  Science signaling
  
  Volume: 12 Issue: 576 Pages: 4847-4847
- DOI
  10.1126/scisignal.aaw4847
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01845, KAKENHI-PROJECT-18H02597, KAKENHI-PROJECT-15K06774, KAKENHI-PROJECT-18K11044, KAKENHI-PROJECT-18K06864, KAKENHI-PROJECT-19K06955, KAKENHI-PROJECT-19K22834, KAKENHI-PUBLICLY-18H04695, KAKENHI-PROJECT-16K05843, KAKENHI-PLANNED-26111004, KAKENHI-PROJECT-17H06228
[Journal Article] Contribution of Coiled-Coil Assembly to Ca2+/Calmodulin-Dependent Inactivation of TRPC6 Channel and its Impacts on FSGS-Associated Phenotypes2019
- Author(s)
  Polat Onur K.、Uno Masatoshi、Maruyama Terukazu、Tran Ha Nam、Imamura Kayo、Wong Chee Fah、Sakaguchi Reiko、Ariyoshi Mariko、Itsuki Kyohei、Ichikawa Jun、Morii Takashi、Shirakawa Masahiro、Inoue Ryuji、Asanuma Katsuhiko、Reiser Jochen、Tochio Hidehito、Mori Yasuo、Mori Masayuki X.
- Journal Title
  
  Journal of the American Society of Nephrology
  
  Volume: 30 Issue: 9 Pages: 1587-1603
- DOI
  10.1681/asn.2018070756
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06872, KAKENHI-PROJECT-18K12047, KAKENHI-PROJECT-18K19297, KAKENHI-PUBLICLY-18H04695, KAKENHI-PROJECT-16K05843, KAKENHI-PROJECT-15H04678, KAKENHI-PROJECT-18H02823, KAKENHI-PROJECT-17H06228, KAKENHI-PROJECT-17H01213
[Journal Article] Intracellular thermometry with fluorescent sensors for thermal biology2018
- Author(s)
  Okabe Kohki、Sakaguchi Reiko、Shi Beini、Kiyonaka Shigeki
- Journal Title
  
  Pflugers Arch.
  
  Volume: - Issue: 5 Pages: 717-731
- DOI
  10.1007/s00424-018-2113-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05931, KAKENHI-PUBLICLY-18H04695
[Journal Article] Methyl transfer by substrate signaling from a knotted protein fold2016
- Author(s)
  Christian, T.
- Journal Title
  
  Nature Structural and Molecular Biology
  
  Volume: 23 Issue: 10 Pages: 941-948
- DOI
  10.1038/nsmb.3282
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01548, KAKENHI-PROJECT-16H04756, KAKENHI-PROJECT-16K05843
[Journal Article] Fluorescent sensors reveal subcellular thermal changes2015
- Author(s)
  Reiko Sakaguchi, Shigeki Kiyonaka, Yasuo Mori
- Journal Title
  
  Current Opinion in Biotechnology
  
  Volume: 31 Pages: 57-64
- DOI
  10.1016/j.copbio.2014.07.013
- NAID
  120005474467
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26870291
[Journal Article] Validating subcellular thermal changes revealed by fluorescent thermosensors2015
- Author(s)
  Kiyonaka S, Sakaguchi R, Hamachi I, Morii T, Yoshizaki T, Mori Y
- Journal Title
  
  Nature Method.
  
  Volume: 12 Issue: 9 Pages: 801-802
- DOI
  10.1038/nmeth.3548
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26111004, KAKENHI-PROJECT-26870291, KAKENHI-PROJECT-25282238
[Journal Article] Deciphering Subtype-Selective Modulations in TRPA1 Biosensor Channels2014
- Author(s)
  Daisuke Kozai, Reiko Sakaguchi, Tomohiko Ohwada, Yasuo Mori
- Journal Title
  
  Current Neuropharmacology
  
  Volume: 12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26870291
[Patent] 腎臓疾患の予防および／または治療用医薬組成物2023
- Inventor(s)
  永田龍,猪阪善隆,山本毅士,余西洋明,森誠之,坂口怜子,岡田亮
- Industrial Property Rights Holder
  永田龍,猪阪善隆,山本毅士,余西洋明,森誠之,坂口怜子,岡田亮
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Overseas
- Data Source
  KAKENHI-PROJECT-21K05272
[Patent] 腎臓疾患の予防および／または治療用医薬組成物2022
- Inventor(s)
  永田龍,猪阪善隆,山本毅士,余西洋明,森誠之,坂口怜子,岡田亮
- Industrial Property Rights Holder
  永田龍,猪阪善隆,山本毅士,余西洋明,森誠之,坂口怜子,岡田亮
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-029773
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-21K05272
[Presentation] Dynamic remodeling of TRPC5-caveolin-1-eNOS complexes regulates the precise signal transfer between Ca2+ and NO2024
- Author(s)
  Reiko Sakaguchi, Nobuaki Takahashi, Takashi Yoshida, Nozomi Ogawa, Yoshifumi Ueda, Satoshi Hamano, Kaori Yamaguchi, Seishiro Sawamura, Shinichiro Yamamoto, Yuji Hara, Tomoya Kawamoto, Akito Nakao, Masayuki X. Mori, Tetsushi Furukawa, Shunichi Shimizu, Ryuji Inoue, and Yasuo Mori
- Organizer
  第101回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-21K05272
[Presentation] PAN腎症モデルラットに対するTRPC3/6チャネル阻害剤L862による蛋白尿改善2023
- Author(s)
  坂口怜子、松田由宗、岡田亮、木稲真利慧、永田龍、森誠之
- Organizer
  第100回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-21K05272
[Presentation] イオンチャネル機能と連動する蛋白尿におけるバイオマーカーの探索2023
- Author(s)
  松田由宗、坂口怜子、岡田亮、木原隆典、永田龍、森誠之
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K05272
[Presentation] TRPC5-Caveolin-1-eNOSシグナルタンパク質複合体が内皮細胞におけるCa2+とNOシグナル調節に果たす役割2023
- Author(s)
  坂口怜子，森誠之, 森泰生
- Organizer
  第52回日本心脈管作動物質学会
- Data Source
  KAKENHI-PROJECT-21K05272
[Presentation] 蛋白尿改善を目指したイオンチャネル阻害剤の開発と評価2023
- Author(s)
  坂口怜子, 松田由宗, 岡田亮, 石兼真, 高橋富美, 片渕瑛介, 中山敏幸, 眞田賢哉, 上田陽一, 木原隆典, 永田龍, 森誠之
- Organizer
  令和５年度産業医科大学学会
- Data Source
  KAKENHI-PROJECT-21K05272
[Presentation] Effect of novel selective TRPC3/6 dual inhibitor L862 to rat PAN-induced nephropathy2023
- Author(s)
  Reiko Sakaguchi, Yoshimune Matsuda, Ryo Okada, Marie Konomi, Takanori Kihara, Takeshi Yamamoto, Yoshitaka Isaka, Ryu Nagata, Masayuki X. Mori
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K05272
[Presentation] 新規選択的TRPC3/6チャネルブロッカーによるラットPAN-誘導性腎症の緩和2022
- Author(s)
  坂口怜子、岡田亮、松田由宗、木稲真利慧、永田龍、森誠之
- Organizer
  第99回　日本生理学会大会
- Data Source
  KAKENHI-PROJECT-21K05272
[Presentation] Visualization and Understanding of Subcellular Thermodynamics using Fluorescent Protein-based Thermosensors2021
- Author(s)
  坂口怜子
- Organizer
  第59回　生物物理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-21K05272
[Presentation] TRPC5 channel-Caveolin-1-eNOS signalplexes coordinate interplay between Ca2+ and NO signals in endothelial cells.2020
- Author(s)
  Reiko Sakaguchi
- Organizer
  1st WPI NanoLSI-iCeMS Joint Symposium on Nanoimaging and Advanced Materials for Life Science.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K05843
[Presentation] 生体内シグナルの可視化と制御2019
- Author(s)
  坂口　怜子
- Organizer
  新学術領域「酸素生物学」シンポジウム「分子から個体へ：俯瞰と接近の生命科学」
- Data Source
  KAKENHI-PROJECT-16K05843
[Presentation] 蛍光性タンパク質温度センサーを用いた生体内温度分布の可視化とその意義の解明2019
- Author(s)
  坂口怜子, 森泰生
- Organizer
  第19回日本蛋白質科学会年会第71回日本細胞生物学会大会合同年次大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04695
[Presentation] Development of fluorescent tools to visualize intracellular signaling.2019
- Author(s)
  Reiko Sakaguchi
- Organizer
  International Symposium of Biofunctional Chemistry
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04695
[Presentation] 蛍光性タンパク質温度センサーを用いた生体内温度分布の可視化とその意義の解明2019
- Author(s)
  坂口怜子, 森泰生
- Organizer
  第19回日本蛋白質科学会年会第71回日本細胞生物学会大会合同年次大会
- Invited
- Data Source
  KAKENHI-PROJECT-16K05843
[Presentation] Development of fluorescent tools to visualize intracellular signaling2019
- Author(s)
  Reiko Sakaguchi
- Organizer
  International Symposium of Biofunctional Chemistry
- Invited
- Data Source
  KAKENHI-PROJECT-17H06228
[Presentation] 蛍光性タンパク質温度センサーを用いた生体内温度分布の可視化とその意義の解明2019
- Author(s)
  坂口怜子, 森泰生
- Organizer
  第19回日本蛋白質科学会年会第71回日本細胞生物学会大会合同年次大会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06228
[Presentation] Development of fluorescent tools to visualize intracellular signaling.2019
- Author(s)
  Reiko Sakaguchi
- Organizer
  International Symposium of Biofunctional Chemistry
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K05843
[Presentation] ミトコンドリアのエネルギー産生システムの理解を目指した細胞内温度センサーの開発2019
- Author(s)
  坂口怜子、清中茂樹、森井孝、森泰生
- Organizer
  京都大学エネルギー理工学研究所ゼロエミッションエネルギー研究拠点平成３０年度共同利用・共同研究成果報告会
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04695
[Presentation] 生体内シグナルの可視化と制御2019
- Author(s)
  坂口　怜子
- Organizer
  新学術領域「酸素生物学」シンポジウム「分子から個体へ：俯瞰と接近の生命科学」
- Data Source
  KAKENHI-PUBLICLY-18H04695
[Presentation] TRPC5 channel-Caveolin-1-eNOS signalplexes coordinate interplay between Ca2+ and NO signals in endothelial cells2018
- Author(s)
  Reiko Sakaguchi
- Organizer
  The 18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K05843
[Presentation] Development of Intracellular Thermosensors for the Understanding of Energy Production in Mitochondria2018
- Author(s)
  Reiko Sakaguchi
- Organizer
  The 9th International Symposium of Advanced Energy Science
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04695
[Presentation] 二光子励起リン光寿命イメージングによる腫瘍深部酸素濃度の非侵襲的定量2018
- Author(s)
  坂口怜子, et al.
- Organizer
  第41回日本分子生物学会年会（パシフィコ横浜）
- Data Source
  KAKENHI-PROJECT-17H06228
[Presentation] Development of Intracellular Thermosensors for the Understanding of Energy Production in Mitochondria2018
- Author(s)
  Reiko Sakaguchi
- Organizer
  The 9th International Symposium of Advanced Energy Science, (Kihada Hall, Uji Obaku Plaza, Kyoto University)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06228
[Presentation] TRPC5 channel-Caveolin-1-eNOS signalplexes coordinate interplay between Ca2+ and NO signals in endothelial cells2018
- Author(s)
  Reiko Sakaguchi
- Organizer
  18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K05843
[Presentation] 二光子励起燐光寿命イメージングによる腫瘍深部酸素濃度の非侵襲的な定量観察2018
- Author(s)
  坂口怜子、吉原利忠、飛田成史、森泰生
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PUBLICLY-18H04695
[Presentation] Development of Real-time Sensors to Visualize Intracellular Signaling Pathway2018
- Author(s)
  Reiko Sakaguchi
- Organizer
  2nd meeting on ”Assembly of Innovatve, Knowledgeable, and Outgoing Chemists”
- Data Source
  KAKENHI-PROJECT-16K05843
[Presentation] 細胞内小器官特異的な熱ダイナミクスの可視化2017
- Author(s)
  安好悠太，波多野雅彦，坂口怜子，清中茂樹，浜地格，森井孝，吉﨑武尚，森泰生
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール、長崎市
- Data Source
  KAKENHI-PROJECT-16K05843
[Presentation] Non-invasive, quantitative visualization of oxygen environment deep inside tumor spheroids by 2-photon excitation phosphorescence lifetime imaging.2017
- Author(s)
  Reiko Sakaguchi, Seiji Tobita, Yasuo Mori.
- Organizer
  第5回低酸素研究会
- Data Source
  KAKENHI-PROJECT-16K05843
[Presentation] Non-invasive, quantitative visualization of oxygen environment deep inside tumor spheroids by 2-photon excitation phosphorescence lifetime imaging.2017
- Author(s)
  Reiko Sakaguchi, Seiji Tobita, Yasuo Mori
- Organizer
  第5回低酸素研究会
- Data Source
  KAKENHI-PROJECT-17H06228
[Presentation] アセトアミノフェンに誘導されるヒト肝ガン細胞死における酸化還元感受性TRPチャネルの役割2016
- Author(s)
  ヘババドゥー、香西大輔、坂口怜子、沼田朋大、森泰生
- Organizer
  第130回日本薬理学会近畿部会
- Place of Presentation
  京都大学百周年時計台記念館、京都市
- Data Source
  KAKENHI-PROJECT-16K05843
[Presentation] 細胞内熱産生機構の可視化-細胞内温度変化は測定可能か？-2016
- Author(s)
  坂口怜子、清中茂樹、森泰生
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター、仙台市
- Invited
- Data Source
  KAKENHI-PROJECT-16K05843
[Presentation] 細胞内発現型温度センサーによるオルガネラ特異的な温度特性の可視化2016
- Author(s)
  坂口怜子、清中茂樹、森泰生
- Organizer
  Biothermology Workshop　生命システムの熱科学
- Place of Presentation
  岡崎コンファレンスセンター、岡崎市
- Data Source
  KAKENHI-PROJECT-16K05843
[Presentation] 蛍光性センサーを用いたイノシトール四リン酸（IP4）の生理学的意義の探索2015
- Author(s)
  坂口怜子、森井孝、森泰生
- Organizer
  生理学研究所研究会「生体シグナルダイナミクス」
- Place of Presentation
  生理学研究所（愛知県岡崎市）
- Year and Date
  2015-09-03
- Data Source
  KAKENHI-PROJECT-26870291
[Presentation] Identification of the Physiological Role of Inositol (1,3,4,5)-Tetrakisphosphate by Fluorescent Biosensors2015
- Author(s)
  Reiko Sakaguchi
- Organizer
  The Second Kitasato-Yale Fluid Symposium: Molecular Control of Cellular and Epithelial Function
- Place of Presentation
  北里大学（東京都港区）
- Year and Date
  2015-12-05
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26870291
[Presentation] Genetically encoded fluorescent thermosensors visualize subcellular thermoregulation in living cells2014
- Author(s)
  Reiko Sakaguchi
- Organizer
  The 87th Annual Meeting of the Japanese Biochemical Society
- Place of Presentation
  Ｋｙｏｔｏ，Ｊａｐａｎ
- Year and Date
  2014-10-17
- Data Source
  KAKENHI-PROJECT-26870291
[Presentation] 異なるメチル基転移酵素による転移RNA認識機構の検討2014
- Author(s)
  坂口　怜子
- Organizer
  第46回　若手ペプチド夏の勉強会
- Place of Presentation
  京都府宮津市
- Year and Date
  2014-08-03
- Invited
- Data Source
  KAKENHI-PROJECT-26870291

1. Hirori Hideki (00512469)

# of Collaborated Projects: 1 results

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2. Furukawa Shuhei (90452276)

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3. 臼井健二 (70543792)

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4. 川野竜司 (90401702)

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5. OKABE Kohki

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6. NAGAO Kohjiro

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7. MORI Masayuki

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8. 山本正道

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9. 中野絵里子

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10. 竹島美幸

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11. 森井孝

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12. 森泰生

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13. 井上隆司

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# of Collaborated Products: 1 results

Sakaguchi Reiko 坂口 怜子

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光照射による一酸化窒素合成酵素の機能模倣システムの構築Principal Investigator

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トランスファーRNA修飾酵素によるタンパク質品質管理機構の解明Principal Investigator

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蛍光性タンパク質温度センサーを用いた生体内温度分布の意義の解明Principal Investigator

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Stimuli-Responsive Synthetic Ion Channels Based on Metal-Organic Polyhedra

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Non-contact and non-invasive manipulation of biological functionalities using all-optical method

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Regulation of cell responses by light controled signal releasing materialPrincipal Investigator

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Development of fluorescent sensors to quantitatively detect signal molecules in single cellsPrincipal Investigator

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[Book] Detection of Inositol Phosphates by Split PH Domains. In: Miller G. (eds) Inositol Phosphates. Methods in Molecular Biology2020

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[Journal Article] A two-step screening to optimize the signal response of an auto-fluorescent protein-based biosensor2022

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[Journal Article] Cell-autonomous control of intracellular temperature by unsaturation of phospholipid acyl chains2022

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[Journal Article] Photoactive carbon monoxide-releasing coordination polymer particles2022

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[Journal Article] Critical contributions of pre-S1 shoulder and distal TRP box in DAG-activated TRPC6 channel by PIP2 regulation2022

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[Journal Article] Osteoclasts adapt to physioxia perturbation through DNA demethylation2021

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[Journal Article] Functionally deficient TRPV6 variants contribute to hereditary and familial chronic pancreatitis2021

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Sakaguchi Reiko 坂口怜子