SHIMADA Atsuhiro 島田敦広

Researcher Number	80723874
Other IDs
Affiliation (Current)	2025: 岐阜大学, 応用生物科学部, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2025: 岐阜大学, 応用生物科学部, 准教授 2017 – 2020: 岐阜大学, 応用生物科学部, 助教 2016: 兵庫県立大学, 生命理学研究科, 客員教員(助教) 2015: 兵庫県立大学, 生命理学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 43040:Biophysics-related / Complex systems / Basic Section 43020:Structural biochemistry-related / Structural biochemistry Except Principal Investigator Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Basic Section 43020:Structural biochemistry-related
Keywords	Principal Investigator 電子伝達 / 金属タンパク質 / 膜タンパク質 / X線自由電子レーザー / 時分割構造解析 / プロトンポンプ / X線発光分光 / 生体エネルギー / XFEL / 時分割X線結晶構造解析 … More / 膜タンパク質複合体 / 金属膜タンパク質 / ポンププローブ実験 / 中間体構造 / 酸素代謝 / 酸素還元 / ヘム / Cytchrome c oxidase / HAG法 / 結晶調温湿装置 / Cytochrome c oxidase / 常温測定 / チトクロム酸化酵素 / 無損傷構造解析 … More Except Principal Investigator 脂質 / RPR / FP / IIAEK / ペプチド / コレステロール / チトクロム酸化酵素 / プロトンポンプ / タンパク質複合体 / 構造と機能 / 生体エネルギー変換 / 膜タンパク質 / 生体超分子 / 酸素還元 / プロトン能動輸送 / 立体構造 / X線結晶構造解析 / 呼吸酵素 / 膜蛋白質 / チトクロムc酸化酵素 Less

Elucidation of the reaction mechanism of cytochrome c oxidase by simultaneous time-resolved X-ray diffraction analysis and X-ray emission spectroscopyPrincipal Investigator
- Principal Investigator
  
  島田敦広
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  Gifu University
Fundamental research on elucidation of novel biological acceptance mechanisms and innovative applications of food-derived lipid metabolism improving peptides
- Principal Investigator
  
  長岡利
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Gifu University
The structure determination of cytochrome c oxidase by pump-probe X-ray crystallography using rapid mixing injector.Principal Investigator
- Principal Investigator
  
  島田敦広
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Gifu University
The elucidation of reaction mechanism of cytochrome c oxidase using XFEL time-resolved structure analysisPrincipal Investigator
- Principal Investigator
  
  Shimada Atsuhiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Gifu University
Fine structures of reaction inter-mediates of bovine cytochrome c oxidase
- Principal Investigator
  
  Tsukihara Tomitake
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  University of Hyogo
The development of the method for determining damage-free crystal structure at room temperature using X-ray free electron laserPrincipal Investigator
- Principal Investigator
  
  SHIMADA Atsuhiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Gifu University
  University of Hyogo

All 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Recent progress in experimental studies on the catalytic mechanism of cytochrome c oxidase2023
- Author(s)
  Shimada Atsuhiro、Tsukihara Tomitake、Yoshikawa Shinya
- Journal Title
  
  Frontiers in Chemistry
  
  Volume: 11
- DOI
  10.3389/fchem.2023.1108190
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-22H04746
[Journal Article] Crystallographic cyanide-probing for cytochrome c oxidase reveals structural bases suggesting that a putative proton transfer H-pathway pumps protons2023
- Author(s)
  Shimada Atsuhiro、Baba Jumpei、Nagao Shuhei、Shinzawa-Itoh Kyoko、Yamashita Eiki、Muramoto Kazumasa、Tsukihara Tomitake、Yoshikawa Shinya
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 299 Issue: 11 Pages: 105277-105277
- DOI
  10.1016/j.jbc.2023.105277
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06130, KAKENHI-PUBLICLY-22H04746
[Journal Article] Critical roles of the CuB site in efficient proton pumping as revealed by crystal structures of mammalian cytochrome c oxidase catalytic intermediates2021
- Author(s)
  Atsuhiro Shimada, Fumiyoshi Hara, Kyoko Shinzawa-Itoh, Nobuko Kanehisa, Eiki Yamashita, Kazumasa Muramoto2, Tomitake Tsukihara, and Shinya Yoshikawa
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 297 Issue: 3 Pages: 100967-100967
- DOI
  10.1016/j.jbc.2021.100967
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06092, KAKENHI-PROJECT-19H03167
[Journal Article] X-ray structures of catalytic intermediates of cytochrome c oxidase provide insights into its O2 activation and unidirectional proton-pump mechanisms2020
- Author(s)
  A. Shimada, Y. Etoh, R. Kitoh-Fujisawa, A. Sasaki, K. Shinzawa-Itoh, T. Hiromoto, E. Yamashita, K. Muramoto, T. Tsukihara, S. Yoshikawa
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 295 Issue: 17 Pages: 5818-5833
- DOI
  10.1074/jbc.ra119.009596
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06092, KAKENHI-PROJECT-18K06162, KAKENHI-PROJECT-17H03646, KAKENHI-PROJECT-18K14635, KAKENHI-PROJECT-19H03167
[Journal Article] Structure Changes Induced by O<sub>2</sub>-binding Tightly Regulate the Proton-pumping of Cytochrome <i>c</i> Oxidase2019
- Author(s)
  SHIMADA Atsuhiro
- Journal Title
  
  Seibutsu Butsuri
  
  Volume: 59 Issue: 2 Pages: 106-107
- DOI
  10.2142/biophys.59.106
- NAID
  130007620410
- ISSN
  0582-4052, 1347-4219
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14635
[Journal Article] Low-dose X-ray structure analysis of cytochrome c oxidase utilizing high-energy X-rays.2019
- Author(s)
  G. Ueno, A. Shimada, E. Yamashita, K. Hasegawa, T. Kumasaka, K. Shinzawa-Itoh, S. Yoshikawa, T. Tsukihara, M. Yamamoto.
- Journal Title
  
  J Synchrotron Radiat.
  
  Volume: 26 Issue: 4 Pages: 912-921
- DOI
  10.1107/s1600577519006805
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06092, KAKENHI-PROJECT-18K14635, KAKENHI-PROJECT-17H03646, KAKENHI-PROJECT-19H03167
[Journal Article] A temperature-controlled cold-gas humidifier and its application to protein crystals with the humid-air and glue-coating method2019
- Author(s)
  Baba Seiki、Shimada Atsuhiro、Mizuno Nobuhiro、Baba Junpei、Ago Hideo、Yamamoto Masaki、Kumasaka Takashi
- Journal Title
  
  Journal of Applied Crystallography
  
  Volume: 52 Issue: 4 Pages: 699-705
- DOI
  10.1107/s1600576719006435
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14635, KAKENHI-PLANNED-19H05783
[Journal Article] X-ray structural analyses of azide-bound cytochrome c oxidases reveal that the H-pathway is critically important for the proton-pumping activity.2018
- Author(s)
  1.Shimada A, Hatano K, Tadehara H, Yano N, Shinzawa-Itoh K, Yamashita E, Muramoto K, Tsukihara T, Yoshikawa S.
- Journal Title
  
  J Biol Chem.
  
  Volume: 293 Issue: 38 Pages: 14868-14879
- DOI
  10.1074/jbc.ra118.003123
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06162, KAKENHI-PROJECT-18K14635, KAKENHI-PROJECT-17H03646
[Journal Article] Structure of bovine cytochrome c oxidase in the ligand-free reduced state at neutral pH2018
- Author(s)
  Luo Fangjia、Shinzawa-Itoh Kyoko、Hagimoto Kaede、Shimada Atsuhiro、Shimada Satoru、Yamashita Eiki、Yoshikawa Shinya、Tsukihara Tomitake
- Journal Title
  
  Acta Crystallographica Section F Structural Biology Communications
  
  Volume: 74 Issue: 2 Pages: 92-98
- DOI
  10.1107/s2053230x17018532
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K18493, KAKENHI-PROJECT-17H03646
[Journal Article] A nanosecond time-resolved XFEL analysis of structural changes associated with CO release from cytochrome c oxidase.2017
- Author(s)
  Shimada, A.†, Kubo, M.†, Baba, S.† et al. (29人中2番目)(†equal contribution)
- Journal Title
  
  Sci. Adv.
  
  Volume: 3 Issue: 7
- DOI
  10.1126/sciadv.1603042
- NAID
  120006363290
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H03841, KAKENHI-PROJECT-15H05476, KAKENHI-PROJECT-15K18493
[Journal Article] Structure of bovine cytochrome c oxidase crystallized at a neutral pH using a fluorinated detergent2017
- Author(s)
  Luo Fangjia、Shinzawa-Itoh Kyoko、Hagimoto Kaede、Shimada Atsuhiro、Shimada Satoru、Yamashita Eiki、Yoshikawa Shinya、Tsukihara Tomitake
- Journal Title
  
  Acta Crystallographica Section F Structural Biology Communications
  
  Volume: 73 Issue: 7 Pages: 416-422
- DOI
  10.1107/s2053230x17008834
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K18493
[Journal Article] Complex structure of cytochrome c-cytochrome c oxidase reveals a novel protein-protein interaction mode2017
- Author(s)
  Satoru Shimada, Kyoko Shinzawa‐Itoh, Junpei Baba, Shimpei Aoe, Atsuhiro Shimada, Eiki Yamashita, Jiyoung Kang, Masaru Tateno, Shinya Yoshikawa, and Tomitake Tsukihara
- Journal Title
  
  EMBO J.
  
  Volume: 86 Issue: 3 Pages: 291-300
- DOI
  10.15252/embj.201695021
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25287099, KAKENHI-PROJECT-26291033, KAKENHI-PROJECT-15K18493
[Journal Article] The Mg2+-containing Water Cluster of Mammalian Cytochrome c Oxidase Collects Four Pumping Proton Equivalents in Each Catalytic Cycle2016
- Author(s)
  Yano N, Muramoto K, Shimada A, Takemura S, Baba J, Fujisawa H, Mochizuki M, Shinzawa-Itoh K, Yamashita E, Tsukihara T, Yoshikawa S.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 291 Issue: 46 Pages: 23882-23894
- DOI
  10.1074/jbc.m115.711770
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26291033, KAKENHI-PROJECT-15K07029, KAKENHI-PROJECT-15K18493
[Presentation] Electron transfer mechanism proposed by the cryo-EM structure of cytochrome c and cytochrome c oxidase complex2023
- Author(s)
  Yuto Taguchi,Daisuke Kozai, Haruna Naitou, Kouki Nishikawa, Yohnori Huziyoshi, Kazutoshi Tani, Kouichirou Ishimori, Atsuhiro Shimada
- Organizer
  第61回日本生物物理学会年会
- Data Source
  KAKENHI-PUBLICLY-22H04746
[Presentation] シトクロムcから呼吸鎖末端酵素への電子伝達機構解明の試み2023
- Author(s)
  禹昇完、香西大輔、内藤春菜、西川幸希、藤吉好則、石森浩一郎、谷一寿、島田敦広
- Organizer
  第49回生体分子科学討論会
- Data Source
  KAKENHI-PUBLICLY-22H04746
[Presentation] シトクロムc-シトクロム酸化酵素複合体の結晶および非結晶構造から予測される電子伝達機構2023
- Author(s)
  島田敦広
- Organizer
  日本結晶学会年会
- Data Source
  KAKENHI-PUBLICLY-22H04746
[Presentation] 呼吸鎖末端酵素とシアン化物イオンの複合体構造から示唆されるプロトンポンプ機構2023
- Author(s)
  島田敦広、村本和優、伊藤-新澤恭子、月原冨武、吉川信也
- Organizer
  第49回生体分子科学討論会
- Data Source
  KAKENHI-PUBLICLY-22H04746
[Presentation] ウシ心筋由来シトクロム酸化酵素における金属中心の酸化状態変化によって駆動されるプロトン輸送機構の解明2023
- Author(s)
  島田敦広、村本和優、伊藤-新澤恭子、月原冨武、吉川信也
- Organizer
  第23回日本蛋白質科学会年会
- Data Source
  KAKENHI-PUBLICLY-22H04746
[Presentation] Analysis of the electronic state of the metal sites of cytochrome c oxidase using simultaneous XES and XRD measurements2023
- Author(s)
  Keigo Tsuiki, Takahumi Kamei, Takanori Nakane, Tetsuo Katayama, Atsuhiro Shimada
- Organizer
  第61回日本生物物理学会年会
- Data Source
  KAKENHI-PUBLICLY-22H04746
[Presentation] Guanidine/Biguanide 系薬剤とミトコンドリア呼吸鎖末端酵素の相互作用解析2023
- Author(s)
  Seungwan Woo, Gerald I Shulman, Atsuhiro Shimada
- Organizer
  第61回日本生物物理学会年会
- Data Source
  KAKENHI-PUBLICLY-22H04746
[Presentation] Coupling Mechanism Between O2 Reduction and Proton-pumping Reaction Driven by Cytochrome c Oxidase2022
- Author(s)
  Atsuhiro Shimada, Kyoko Shinzawa- Itoh, Kazumasa Muramoto, Tomitake Tsukihara, Shinya Yoshikawa
- Organizer
  International conference on porphyrins and phthalocyanines (ICPP-12)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04746
[Presentation] クライオ電子顕微鏡を用いたシトクロム酸化酵素とシトクロム c の複合体構造解析2022
- Author(s)
  禹昇完（Seungwan Woo）、香西大輔（Daisuke Kozai）、西川幸希（Koki Nishikawa）、藤吉好則（Yoshinori Fujiyoshi）、谷一寿（Kazutoshi Tani）、島田敦広（Atsuhiro Shimada）
- Organizer
  第22回日本蛋白質科学会年会
- Data Source
  KAKENHI-PUBLICLY-22H04746
[Presentation] シアン化物結合シトクロム酸化酵素の結晶構造から示唆される、金属中心の酸化状態変化による活性制御機構2022
- Author(s)
  Atsuhiro Shimada, Kazumasa Muramoto, Kyoko Shinzawa-Itoh, Tomitake Tsukihara, Shinya Yoshikawa
- Organizer
  第60回日本生物物理学会年会
- Data Source
  KAKENHI-PUBLICLY-22H04746
[Presentation] O2-activation and unidirectional proton transfer mechanism by cytochrome c oxidase elucidated by X-ray structures of its catalytic intermediate2020
- Author(s)
  Shimada, A
- Organizer
  第20回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-18K14635
[Presentation] 構造から見たチトクロム酸化酵素のH-経路を介したプロトン能動輸送機構の普遍性2020
- Author(s)
  島田敦広、月原冨武、吉川信也
- Organizer
  日本結晶学会年会
- Data Source
  KAKENHI-PROJECT-18K06092
[Presentation] O2-activation and unidirectional proton-pump mechanisms of cytochrome c oxidase elucidated by X-ray structures of its catalytic intermediates2020
- Author(s)
  A. Shimada, Y. Eto, K. Shinzawa-Itoh, E. Yamashita, K. Muramoto, T. Tsukihara, S. Yoshikawa
- Organizer
  第20回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-18K06092
[Presentation] The structural analysis of cytochrome c oxidase complexed with cytochrome c using cryo-electron microscopy2020
- Author(s)
  Shimada, A., Kozai, D., Nishikawa, K., Fujiyoshi, Y., Sho, G., Mizutani, T. and Tani, K
- Organizer
  第58回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-18K14635
[Presentation] O2-activation and unidirectional proton-pump mechanisms of cytochrome c oxidase elucidated by X-ray structures of its catalytic intermediates2019
- Author(s)
  Shimada Atsuhiro、Etoh Yuki、Shinzawa-Itoh Kyoko、Yamashita Eiki、Muramoto Kazumasa、Tsukihara Tomitake、Yoshikawa Shinya
- Organizer
  International Symposium on Diffraction Structural Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14635
[Presentation] Influence of differences in X-ray dose on crystal structure of cytochrome c oxidase.2019
- Author(s)
  G. Syo, A. Miyamoto, K. Ashida, K. Shinzawa-Itoh, A. Shimada, T. Tsukihara, S. Yoshikawa.
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-18K06092
[Presentation] チトクロム酸化酵素反応中間体の構造解析による、酸素還元と共役したプロトンポンプ機構の解明2019
- Author(s)
  島田敦広、村本和優、伊藤-新澤恭子、月原冨武、吉川信也
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-18K14635
[Presentation] Intermediate structure of cytochrome c oxidase provide insights into the mechanism of unidirectional proton pump coupled with O2 reduction.2019
- Author(s)
  A. Shimada, K. Muramoto, K. Shinzawa-Itoh, T. Tsukihara, S. Yoshikawa.
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-18K06092
[Presentation] Structure determination of reduced cytochrome c oxidase using non-frozen crystal.2019
- Author(s)
  T. Mizutani, A. Miyamoto, K. Ashida, K. Shinzawa-Itoh, A. Shimada, T. Tsukihara, S. Yoshikawa.
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-18K06092
[Presentation] X線照射量の違いがチトクロム酸化酵素の結晶構造へ与える影響2019
- Author(s)
  Gyokucho Sho、Akari Miyamoto、Kazuma ashida、Kyoko Ito-Shinzawa、Astuhiro Shimada、Tomitake Tsukihara、Shinnya yoshikawa
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-18K14635
[Presentation] Structure changes induced by O2-binding tightly regulate the proton-pumping of cytochrome c oxidase2018
- Author(s)
  Atsuhiro Shimada, Minoru Kubo, Seiki Baba, Hideo Ago, Tomitake Tsukihara, Shinya Yoshikawa
- Organizer
  第５６回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-18K06092
[Presentation] チトクロム酸化酵素によるプロトンポンプは、酸素結合によって誘起されるタンパク質内構造変化によって厳密に制御されている2018
- Author(s)
  島田敦広、久保稔、馬場清喜、吾郷日出夫、吉川信也、月原冨武
- Organizer
  第56回日本生物物理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-18K14635
[Presentation] Reaction mechanism of cytochrome c oxidase elucidated by high-resolution crystal structural analyses2018
- Author(s)
  Tomitake Tsukihara, Atsuhiro Shimada, Shinya Yoshikawa
- Organizer
  第１８回日本蛋白質科学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06092
[Presentation] A nanosecond time-resolved XFEL structure analysis reveals the structural changes associated with CO release from Cytochrome c Oxidase2018
- Author(s)
  Atsuhiro Shimada, Minoru Kubo, Seiki Baba, Hideo Ago, Tomitake Tsukihara, Shinya Yoshikawa
- Organizer
  第１８回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-18K06092
[Presentation] 構造解析における動的揺らぎと構造多型の区別-CO結合還元型チトクロム酸化酵素のX線結晶構造解析の場合2018
- Author(s)
  島田敦広、矢野直峰、山下栄樹、廣本武史、伊藤-新澤恭子、吉川信也、月原冨武
- Organizer
  日本結晶学会年会
- Data Source
  KAKENHI-PROJECT-18K06092
[Presentation] A unique respiratory adaptation in Drosophila independent of supercomplex formation2018
- Author(s)
  Satoru Shimada, Marika Oosaki, Ryoko Takahashi, Shigefumi Uene, Sachiko Yanagisawa, Tomitake Tsukihara, Kyoko Shinzawa-Itoh
- Organizer
  第５６回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-18K06092
[Presentation] A nanosecond time-resolved XFEL structure analysis reveals the structural changes associated with CO release from Cytochroem c Oxidase2018
- Author(s)
  Atsuhiro Shimada, Minoru Kubo, Seiki Baba, Hideo Ago, Tomitake Tsukihara, Shinya Yoshikawa
- Organizer
  第18回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-18K14635
[Presentation] ウシ心筋チトクロム酸化酵素の常温還元型構造解析2017
- Author(s)
  宮本朱梨、田本和宏、芦田和馬、島田敦広、熊坂崇、馬場清喜、伊藤ー新澤恭子、月原冨武、吉川信也
- Organizer
  第90回日本生化学会合同大会
- Data Source
  KAKENHI-PROJECT-15K18493
[Presentation] X線自由電子レーザーを光源とするフェムト秒X線結晶構造解析2017
- Author(s)
  吾郷日出夫、島田敦広、久保稔、馬場清喜、山下恵太郎、平田邦生、上野剛、山本雅貴
- Organizer
  第90回日本生化学会合同大会
- Data Source
  KAKENHI-PROJECT-15K18493
[Presentation] A nanosecond time-resolved XFEL analysis of structural changes associated with CO release from cytochrome co oxidase2017
- Author(s)
  島田敦広、久保稔、馬場清喜、吾郷日出夫、吉川信也、月原冨武
- Organizer
  第55回日本生物物理学会
- Invited
- Data Source
  KAKENHI-PROJECT-15K18493
[Presentation] X線自由電子レーザーを用いたチトクロム酸化酵素の時分割構造解析によって明らかとなった、リガンド結合に伴うプロトンポンプ経路の閉鎖機構2017
- Author(s)
  島田敦広、久保稔、馬場清喜、吾郷日出夫、吉川信也、月原冨武
- Organizer
  第17回日本蛋白質科学会
- Invited
- Data Source
  KAKENHI-PROJECT-15K18493
[Presentation] チトクロム酸化酵素の様々な反応中間体及び反応中間体類似物の構造から提唱されるプロトンポンプ機構2016
- Author(s)
  島田敦広、馬場淳平、山下栄樹、村本和優、伊藤―新澤恭子、月原冨武、吉川信也
- Organizer
  第16回日本蛋白質科学会
- Place of Presentation
  福岡国際会議場(福岡県福岡市博多区)
- Year and Date
  2016-06-07
- Data Source
  KAKENHI-PROJECT-15K18493
[Presentation] X線自由電子レーザーを用いたチトクロム酸化酵素の時分割構造解析から明らかとなった、銅イオンへの配位子結合によって制御されるプロトンポンプ経路の閉鎖メカニズム2016
- Author(s)
  島田敦広, 波多野啓太, 宮本朱梨, 伊藤-新澤恭子, 久保稔, 馬場清喜, 熊坂崇, 山本雅貴, 吾郷日出夫, 平田邦生, 山下恵太郎, 山下栄樹, 上野剛, 吉川信也, 月原冨武
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター(宮城県仙台市青葉区)
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-15K18493
[Presentation] Mg2+-containing water cluster, collecting four pumping proton equivalents in each catalytic cycle, enable the effective proton-pumping in bovine cytochrome c oxidase2016
- Author(s)
  島田敦広, 矢野直峰, 村本和優, 武村修平, 馬場淳平, 望月正雄, 伊藤―新澤恭子, 山下栄樹, 月原冨武, 吉川信也
- Organizer
  THE 42nd NAITO CONFERENCE ON “In the Vanguard of Structural Biology: Revolutionizing Life Sciences”
- Place of Presentation
  シャトレーゼガトーキングダムサッポロ(北海道札幌市)
- Year and Date
  2016-10-04
- Data Source
  KAKENHI-PROJECT-15K18493
[Presentation] High-resolution crystal structure of cytochrome c oxidase reveals the mechanism of high efficient proton pumping2016
- Author(s)
  島田敦広, 矢野直峰, 村本和優, 山下栄樹, 伊藤―新澤恭子, 月原冨武, 吉川信也
- Organizer
  第54回日本生物物理学会
- Place of Presentation
  つくば国際会議場(茨城県つくば市)
- Year and Date
  2016-11-25
- Data Source
  KAKENHI-PROJECT-15K18493
[Presentation] チトクロム酸化酵素の様々な反応中間体及び反応中間体類似物の構造から提唱されるプロトンポンプ機構2016
- Author(s)
  島田敦広，馬場淳平，山下栄樹，村本和優，伊藤―新澤恭子，月原冨武，吉川信也
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡国際会議場(福岡県福岡市博多区)
- Year and Date
  2016-06-07
- Data Source
  KAKENHI-PROJECT-15K18493
[Presentation] The damage-free crystal structure of cytochrome c oxidase at the resting oxidized state determined using X-ray free electron laser2016
- Author(s)
  島田敦広, 伊藤―新澤恭子, 久保稔, 馬場清喜, 熊坂崇, 山本雅貴, 吾郷日出夫, 平田邦生, 山下恵太郎, 山下栄樹, 上野剛, 吉川信也, 月原冨武
- Organizer
  EMBO Conference “The biochemistry and chemistry of biocatalysis: From understanding to design”
- Place of Presentation
  オウル大学(フィンランド・オウル)
- Year and Date
  2016-06-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18493
[Presentation] チトクロム酸化酵素F型中間体の1.6Å分解能X線結晶構造解析2016
- Author(s)
  江藤勇樹，島田敦広，山下栄樹，伊藤―新澤恭子，月原冨武，吉川信也
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡国際会議場(福岡県福岡市博多区)
- Year and Date
  2016-06-07
- Data Source
  KAKENHI-PROJECT-15K18493
[Presentation] Processing of XFEL still images with a reference oscillation data set for crystal structural analyses of cytochrome c oxidase2016
- Author(s)
  Luo Fangjia , 島田敦広, 山下恵太郎, 平田邦生, 伊藤―新澤恭子, 月原冨武, 吉川信也
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡国際会議場(福岡県福岡市博多区)
- Year and Date
  2016-06-07
- Data Source
  KAKENHI-PROJECT-15K18493
[Presentation] チトクロムcとチトクロム酸化酵素の複合体での結晶構造が示す新しい蛋白質間相互作用様式2016
- Author(s)
  島田悟，青江新平，伊藤―新澤恭子，馬場淳平，島田敦広，Jiyoung Kang，舘野賢，山下栄樹，吉川信也，月原冨武
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡国際会議場(福岡県福岡市博多区)
- Year and Date
  2016-06-07
- Data Source
  KAKENHI-PROJECT-15K18493
[Presentation] Observation of water channel opening upon CO photolysis in cytochrome c oxidase by time-resolved XFEL crystallography and IR spectroscopy2016
- Author(s)
  久保稔, 島田敦広, 馬場清喜, 山下恵太郎, 平田邦生, 山本雅貴, 伊藤―新澤恭子, 月原冨武, 吾郷日出夫, 吉川信也
- Organizer
  THE 42nd NAITO CONFERENCE ON “In the Vanguard of Structural Biology: Revolutionizing Life Sciences”
- Place of Presentation
  シャトレーゼガトーキングダムサッポロ(北海道札幌市)
- Year and Date
  2016-10-04
- Data Source
  KAKENHI-PROJECT-15K18493
[Presentation] X線自由電子レーザーを用いた、ポンプ・プローブ法によるチトクロム酸化酵素の時分割結晶構造解析2016
- Author(s)
  波多野啓太，島田敦広，宮本朱梨，馬場清喜，山下恵太郎，久保稔，吾郷日出夫，平田邦生，上野剛，村上博則，山本雅貴，熊坂崇，山下栄樹，小倉尚志，伊藤―新澤恭子，月原冨武，吉川信也
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡国際会議場(福岡県福岡市博多区)
- Year and Date
  2016-06-07
- Data Source
  KAKENHI-PROJECT-15K18493
[Presentation] 常温での高分解能データ収集に必要なチトクロム酸化酵素結晶の凍結解凍法の確立2016
- Author(s)
  宮本朱梨，島田敦広，波多野啓太，馬場清喜，熊坂崇，伊藤―新澤恭子，月原冨武，吉川信也
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡国際会議場(福岡県福岡市博多区)
- Year and Date
  2016-06-07
- Data Source
  KAKENHI-PROJECT-15K18493
[Presentation] チトクロム酸化酵素内のMgを含む水クラスターが酸素取り込み前に4等量のプロトンを蓄積することで、高効率プロトンポンプ反応を可能にする2015
- Author(s)
  島田敦広、矢野直峰、馬場淳平、武村秀平、村本和優、山下栄樹、伊藤―新澤恭子、前田友子、月原冨武、吉川信也
- Organizer
  第15回日本蛋白質科学会
- Place of Presentation
  あわぎんホール(徳島県徳島市)
- Year and Date
  2015-06-24
- Data Source
  KAKENHI-PROJECT-15K18493
[Presentation] チトクロム酸化酵素に対するチトクロムcの2つの結合部位のX線構造解析2015
- Author(s)
  島田悟、青江新平、伊藤―新澤恭子、馬場淳平、島田敦広、山下栄樹、吉川信也、月原冨武
- Organizer
  第53回日本生物物理学会
- Place of Presentation
  金沢大学角間キャンパス(石川県金沢市)
- Year and Date
  2015-09-13
- Data Source
  KAKENHI-PROJECT-15K18493
[Presentation] 第２のチトクロムc結合部位を持つチトクロムc酸化酵素共結晶のX線結晶構造解析2015
- Author(s)
  青江新平、島田悟、伊藤―新澤恭子、島田敦広、馬場淳平、武村秀平、山下栄樹、吉川信也、月原冨武
- Organizer
  第15回日本蛋白質科学会
- Place of Presentation
  あわぎんホール(徳島県徳島市)
- Year and Date
  2015-06-24
- Data Source
  KAKENHI-PROJECT-15K18493
[Presentation] ウシ心筋チトクロム酸化酵素O型中間体のX線結晶構造解析2015
- Author(s)
  江藤勇樹、島田敦広、原史剛、山下栄樹、伊藤―新澤恭子、月原冨武、吉川信也
- Organizer
  第53回日本生物物理学会
- Place of Presentation
  金沢大学角間キャンパス(石川県金沢市)
- Year and Date
  2015-09-13
- Data Source
  KAKENHI-PROJECT-15K18493
[Presentation] チトクロム酸化酵素F型中間体の高分解能X線結晶構造解析2015
- Author(s)
  江藤勇樹、島田敦広、前田友子、山下栄樹、村本和優、伊藤―新澤恭子、月原冨武、吉川信也
- Organizer
  第15回日本蛋白質科学会
- Place of Presentation
  あわぎんホール(徳島県徳島市)
- Year and Date
  2015-06-24
- Data Source
  KAKENHI-PROJECT-15K18493
[Presentation] チトクロムcとチトクロム酸化酵素共結晶の高分解能X線結晶構造に基づく相互作用解明2015
- Author(s)
  島田悟、青江新平、伊藤―新澤恭子、島田敦広、馬場淳平、武村秀平、山下栄樹、吉川信也、月原冨武
- Organizer
  第15回日本蛋白質科学会
- Place of Presentation
  あわぎんホール(徳島県徳島市)
- Year and Date
  2015-06-24
- Data Source
  KAKENHI-PROJECT-15K18493
[Presentation] チトクロム酸化酵素の真のアジ化物イオン結合型構造により明らかになった、酸素還元中心の構造変化とプロトンポンプ経路の関係性2015
- Author(s)
  波多野啓太、島田敦広、引田理英、蓼原瞳、山本旭麻、山下栄樹、前田友子、伊藤―新澤恭子、月原冨武、吉川信也
- Organizer
  第15回日本蛋白質科学会
- Place of Presentation
  あわぎんホール(徳島県徳島市)
- Year and Date
  2015-06-24
- Data Source
  KAKENHI-PROJECT-15K18493
[Presentation] 中性領域(pH7.3)でのウシ心筋チトクロム酸化酵素の結晶化及び構造解明2015
- Author(s)
  萩本楓、伊藤―新澤恭子、島田敦広、島田悟、Luo Fangjia、山下栄樹、吉川信也、月原冨武
- Organizer
  第15回日本蛋白質科学会
- Place of Presentation
  あわぎんホール(徳島県徳島市)
- Year and Date
  2015-06-24
- Data Source
  KAKENHI-PROJECT-15K18493
[Presentation] 高分解能X線結晶構造解析によるチトクロム酸化酵素の酸素還元・プロトンポンプ機構の解明2015
- Author(s)
  月原冨武、島田敦広、島田悟、武村秀平、馬場淳平、村本和優、山下栄樹、伊藤―新澤恭子、吉川信也
- Organizer
  第15回日本蛋白質科学会
- Place of Presentation
  あわぎんホール(徳島県徳島市)
- Year and Date
  2015-06-24
- Data Source
  KAKENHI-PROJECT-15K18493
[Presentation] チトクロム酸化酵素を用いた常温高分解能X線回折実験法の確立2015
- Author(s)
  波多野啓太、宮本朱梨、島田敦広、馬場清喜、熊坂崇、伊藤―新澤恭子、月原冨武、吉川信也
- Organizer
  第53回日本生物物理学会
- Place of Presentation
  金沢大学角間キャンパス(石川県金沢市)
- Year and Date
  2015-09-13
- Data Source
  KAKENHI-PROJECT-15K18493
[Presentation] チトクロム酸化酵素の高分解能X線結晶構造解析から明らかとなった、酸素還元反応と共役したプロトン輸送機序2015
- Author(s)
  島田敦広、矢野直峰、岸田佳織、馬場淳平、江藤勇樹、波多野啓太、山下栄樹、伊藤―新澤恭子、月原冨武、吉川信也
- Organizer
  第53回日本生物物理学会
- Place of Presentation
  金沢大学角間キャンパス(石川県金沢市)
- Year and Date
  2015-09-13
- Invited
- Data Source
  KAKENHI-PROJECT-15K18493
[Presentation] シアン結合完全還元型チトクロム酸化酵素のX線結晶構造解析から明らかになった、活性中心を構成するheme a3の高い可動性2015
- Author(s)
  馬場淳平、島田敦広、山下栄樹、伊藤―新澤恭子、村本和優、月原冨武、吉川信也
- Organizer
  第15回日本蛋白質科学会
- Place of Presentation
  あわぎんホール(徳島県徳島市)
- Year and Date
  2015-06-24
- Data Source
  KAKENHI-PROJECT-15K18493

1. Tsukihara Tomitake (00032277)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 吉川信也 (40068119)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
3. 中根崇智 (50794905)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 片山哲夫 (90648073)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 長岡利 (50202221)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 松井利郎 (20238942)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 海老原章郎 (60415099)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 本多裕之 (70209328)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 村本和優

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 久保稔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 月原富武

# of Collaborated Projects: 0 results

# of Collaborated Products: 13 results
12. 舘野賢

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 新沢伊藤恭子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

SHIMADA Atsuhiro 島田 敦広

Research Projects

Research Products

Co-Researchers

Elucidation of the reaction mechanism of cytochrome c oxidase by simultaneous time-resolved X-ray diffraction analysis and X-ray emission spectroscopyPrincipal Investigator

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Fundamental research on elucidation of novel biological acceptance mechanisms and innovative applications of food-derived lipid metabolism improving peptides

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The structure determination of cytochrome c oxidase by pump-probe X-ray crystallography using rapid mixing injector.Principal Investigator

Principal Investigator

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The elucidation of reaction mechanism of cytochrome c oxidase using XFEL time-resolved structure analysisPrincipal Investigator

Principal Investigator

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Fine structures of reaction inter-mediates of bovine cytochrome c oxidase

Principal Investigator

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The development of the method for determining damage-free crystal structure at room temperature using X-ray free electron laserPrincipal Investigator

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[Journal Article] Recent progress in experimental studies on the catalytic mechanism of cytochrome c oxidase2023

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[Journal Article] Crystallographic cyanide-probing for cytochrome c oxidase reveals structural bases suggesting that a putative proton transfer H-pathway pumps protons2023

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[Journal Article] Critical roles of the CuB site in efficient proton pumping as revealed by crystal structures of mammalian cytochrome c oxidase catalytic intermediates2021

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[Journal Article] X-ray structures of catalytic intermediates of cytochrome c oxidase provide insights into its O2 activation and unidirectional proton-pump mechanisms2020

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[Journal Article] Structure Changes Induced by O<sub>2</sub>-binding Tightly Regulate the Proton-pumping of Cytochrome <i>c</i> Oxidase2019

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[Journal Article] Low-dose X-ray structure analysis of cytochrome c oxidase utilizing high-energy X-rays.2019

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[Journal Article] A temperature-controlled cold-gas humidifier and its application to protein crystals with the humid-air and glue-coating method2019

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[Journal Article] X-ray structural analyses of azide-bound cytochrome c oxidases reveal that the H-pathway is critically important for the proton-pumping activity.2018

Author(s)

SHIMADA Atsuhiro 島田敦広