Otaki Yoichiro 大瀧陽一郎

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Yoichiro Otaki 大瀧陽一郎

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Researcher Number	80732693
Other IDs
Affiliation (Current)	2025: 山形大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2019 – 2024: 山形大学, 医学部, 助教 2018: 山形大学, 医学部, 医員 2014 – 2015: 山形大学, 医学部, 医員
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / Cardiovascular medicine Except Principal Investigator Basic Section 53020:Cardiology-related
Keywords	Principal Investigator 病的心肥大 / GDF15 / Sema6c / セマフォリン / プレキシン受容体 / PlexinB1経路 / 心不全 / PlexinB1 / BMAL1 / Heart Failure … More / Cardiac hypertrophy / Sema4D / Plexin B1 / 左室肥大 / ITCHとDVLの相互作用 / 心肥大 / 大動脈弁狭窄症 / Circular ITCH / HECT type E3 ligase ITCH / Aortic sclerosis / LVH / Dvl / HECT-type E3 ligase ITCH / aortic stenosis / cardiac hypertrophy / ITCH E3 ligase / Myocardial infarction / Apoptosis / ROS / 心筋梗塞 / ユビキチン転移酵素 / 翻訳後修飾 / ITCH / ユビキチン / 酸化ストレス … More Except Principal Investigator 病的心肥大 / 心腎症候群 / 初期エンドソーム / Rabaptin5 / Hippo pathway / 大動脈弁狭窄症 / NPHP4 / セマフォリン / セマフォリン３C / セマフォリン3C / Wnt/β catenin signaling / Cardio-renal syndrome / Semaphorin 3C Less

高血圧性心疾患発症における膜貫通型セマフォリン６Cの機能解明とGDF15との関連Principal Investigator
- Principal Investigator
  
  大瀧陽一郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Yamagata University
石灰化大動脈弁狭窄症の発症におけるメカノセンサーNPHP4の役割解明
- Principal Investigator
  
  高橋大
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Yamagata University
心腎症候群発症における初期エンドソーム調節因子Rabaptin5の機能解明
- Principal Investigator
  
  渡辺昌文
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Yamagata University
Plexin B1 Exacerbates Cardiac Hypertrophy and Heart FailurePrincipal Investigator
- Principal Investigator
  
  Yoichiro Otaki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Yamagata University
Functional analysis of renal tubule-derived semaphorin 3C in the development of cardiorenal syndrome
- Principal Investigator
  
  Watanabe Masafumi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Yamagata University
The role of circular RNA ITCH in the development of aortic stenosisPrincipal Investigator
- Principal Investigator
  
  Yoichiro Otaki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Yamagata University
The HECT-Type Ubiquitin E3 Ligase ITCH Interacts with Thioredoxin-Interacting Protein and Ameliorates Reactive Oxygen Species-Induced CardiotoxicityPrincipal Investigator
- Principal Investigator
  
  Otaki Yoichiro
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Yamagata University

All 2020 2016 2015 Other

All Journal Article Presentation

[Journal Article] HECT(Homologous to the E6-AP Carboxyl Terminus)-Type Ubiquitin E3 Ligase ITCH Attenuates Cardiac Hypertrophy by Suppressing the Wnt/β-Catenin Signaling Pathway2020
- Author(s)
  Jun Goto, Yoichiro Otaki et al.
- Journal Title
  
  Hypertension
  
  Volume: 76 Issue: 6 Pages: 1868-1878
- DOI
  10.1161/hypertensionaha.120.15487
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15838
[Journal Article] HECT‐Type Ubiquitin E3 Ligase ITCH Interacts With Thioredoxin‐Interacting Protein and Ameliorates Reactive Oxygen Species Induced Cardiotoxicity2016
- Author(s)
  Yoichiro Otaki, Hiroki Takahashi, Tetsu Watanabe, Akira Funayama, Shunsuke Netsu, Yuki Honda, Taro Narumi, Shinpei Kadowaki, Hiromasa Hasegawa, Shintaro Honda, Takanori Arimoto, Tetsuro Shishido, Takuya Miyamoto, Hideaki Kamata, Osamu Nakajima, Isao Kubota
- Journal Title
  
  Am Heart Assoc.
  
  Volume: 5 Issue: 1
- DOI
  10.1161/jaha.115.002485
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01382, KAKENHI-PUBLICLY-15H01406, KAKENHI-PROJECT-26893025, KAKENHI-PROJECT-26860541
[Journal Article] Comorbid renal tubular damage and hypoalbuminemia exacerbate cardiac prognosis in patients with chronic heart failure2016
- Author(s)
  Yoichiro Otaki, Tetsu Watanabe, Hiroki Takahashi, Akira Funayama, Daisuke Kinoshita, Miyuki Yokoyama, Tetsuya Takahashi, Satoshi Nishiyama, Takanori Arimoto, Tetsuro Shishido, Takuya Miyamoto, Tsuneo Konta, Isao Kubota.
- Journal Title
  
  Clinical reseaarch of Cardioogy
  
  Volume: 105 Issue: 2 Pages: 162-171
- DOI
  10.1007/s00392-015-0899-z
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26893025
[Journal Article] Cystatin C-Based eGFR Is a Superior Prognostic Parameter to Creatinine-Based eGFR in Post-Endovascular Therapy Peripheral Artery Disease Patients2015
- Author(s)
  Yoichiro Otaki, Hiroki Takahashi, Tetsu Watanabe, Gensai Yamaura, Akira Funayama, Takanori Arimoto, Tetsuro Shishido, Takuya Miyamoto, Isao Kubota.
- Journal Title
  
  Circ J
  
  Volume: 79 Issue: 11 Pages: 2480-2486
- DOI
  10.1253/circj.CJ-15-0762
- NAID
  130005104885
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26893025
[Presentation] The HECT-type Ubiquitin E3 ligase ITCH ameliorates left ventricular remodeling and mortality after myocardial infarction
- Author(s)
  Yoichiro Otaki
- Organizer
  米国心臓病学会
- Place of Presentation
  マコーミックプレイス・コンベンションセンター（アメリカ合衆国）
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26893025

1. Watanabe Masafumi (60360096)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 高橋大 (90400548)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 渡邉哲 (40359568)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 鎌田英明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Otaki Yoichiro 大瀧 陽一郎

Yoichiro Otaki 大瀧 陽一郎

Research Projects

Research Products

Co-Researchers

高血圧性心疾患発症における膜貫通型セマフォリン６Cの機能解明とGDF15との関連Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

石灰化大動脈弁狭窄症の発症におけるメカノセンサーNPHP4の役割解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

心腎症候群発症における初期エンドソーム調節因子Rabaptin5の機能解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Plexin B1 Exacerbates Cardiac Hypertrophy and Heart FailurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis of renal tubule-derived semaphorin 3C in the development of cardiorenal syndrome

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of circular RNA ITCH in the development of aortic stenosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The HECT-Type Ubiquitin E3 Ligase ITCH Interacts with Thioredoxin-Interacting Protein and Ameliorates Reactive Oxygen Species-Induced CardiotoxicityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] HECT(Homologous to the E6-AP Carboxyl Terminus)-Type Ubiquitin E3 Ligase ITCH Attenuates Cardiac Hypertrophy by Suppressing the Wnt/β-Catenin Signaling Pathway2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HECT‐Type Ubiquitin E3 Ligase ITCH Interacts With Thioredoxin‐Interacting Protein and Ameliorates Reactive Oxygen Species Induced Cardiotoxicity2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comorbid renal tubular damage and hypoalbuminemia exacerbate cardiac prognosis in patients with chronic heart failure2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cystatin C-Based eGFR Is a Superior Prognostic Parameter to Creatinine-Based eGFR in Post-Endovascular Therapy Peripheral Artery Disease Patients2015

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Presentation] The HECT-type Ubiquitin E3 ligase ITCH ameliorates left ventricular remodeling and mortality after myocardial infarction

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

Otaki Yoichiro 大瀧陽一郎

Yoichiro Otaki 大瀧陽一郎