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Tsunekawa Yuji  恒川 雄二

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Yuji Tsunekawa  恒川 雄二

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Researcher Number 80733352
Other IDs
Affiliation (Current) 2025: 東京大学, 医科学研究所, 助教
Affiliation (based on the past Project Information) *help 2020 – 2025: 東京大学, 医科学研究所, 助教
2018 – 2019: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 研究員
2016 – 2017: 国立研究開発法人理化学研究所, 多細胞システム形成研究センター, 研究員
Review Section/Research Field
Principal Investigator
Basic Section 43060:System genome science-related / Basic Section 42040:Laboratory animal science-related / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Nerve anatomy/Neuropathology
Except Principal Investigator
Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
Keywords
Principal Investigator
Cre de novo ノックイン / リコンビネース / ノックイン / Creノックイン / LsCre / AAV / LsCreの開発 / LeaklessCre / de novo Cre knock-in / 複雑脳の発生 … More / de novoノックイン技術の開発 / 複雑脳におけるAscl1の機能解析 / de novo Cre KI / 複雑脳発生 … More
Except Principal Investigator
MSC / AAV / 遺伝子治療 Less
  • Research Projects

    (5 results)
  • Research Products

    (10 results)
  • Co-Researchers

    (8 People)
  •  組織特異的ヒトボカウイルスベクターの開発Principal Investigator

    • Principal Investigator
      恒川 雄二
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 43060:System genome science-related
    • Research Institution
      The University of Tokyo
  •  アデノ随伴ウイルスベクター基盤技術開発と脳神経疾患に対する遺伝子細胞療法

    • Principal Investigator
      岡田 尚巳
    • Project Period (FY)
      2024 – 2028
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
    • Research Institution
      The University of Tokyo
  •  Development of novel recombinant enzyme for understanding complex brain developmentPrincipal Investigator

    • Principal Investigator
      Tsunekawa Yuji
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 42040:Laboratory animal science-related
    • Research Institution
      The University of Tokyo
  •  Developing new Cre-loxp system for all organismPrincipal Investigator

    • Principal Investigator
      Tsunekawa Yuji
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
    • Research Institution
      Institute of Physical and Chemical Research
  •  Study of molecular mechanism of complex brain by ferretPrincipal Investigator

    • Principal Investigator
      Yuji Tsunekawa
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      Institute of Physical and Chemical Research

All 2023 2022 2019 2017 2016

All Journal Article Presentation Patent

  • [Journal Article] Subcellular mRNA localization and local translation of Arhgap11a in radial glial progenitors regulates cortical development2023

    • Author(s)
      Pilaz LJ, Liu J, Joshi K, Tsunekawa Y, Musso CM, D'Arcy BR, Suzuki IK, Alsina FC, Kc P, Sethi S, Vanderhaeghen P, Polleux F, Silver DL.
    • Journal Title

      Neuron .

      Volume: 111(6) Issue: 6 Pages: 839-856

    • DOI

      10.1016/j.neuron.2023.02.023

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K06464, KAKENHI-PROJECT-23K23891
  • [Journal Article] Development of a novel purification method for AAV vectors using tangential flow filtration2023

    • Author(s)
      Miyaoka Rimi、Tsunekawa Yuji、Kurosawa Yae、Sasaki Takako、Onodera Azusa、Sakamoto Kenji、Kakiuchi Yuko、Wada Mikako、Nitahara‐Kasahara Yuko、Hayashita‐Kinoh Hiromi、Okada Takashi
    • Journal Title

      Biotechnology and Bioengineering

      Volume: 120 Issue: 11 Pages: 3311-3321

    • DOI

      10.1002/bit.28524

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K06064, KAKENHI-PROJECT-22K06921, KAKENHI-PROJECT-20K06464, KAKENHI-PROJECT-23K20328
  • [Journal Article] Large-scale purification of functional AAV particles packaging the full genome using short-term ultracentrifugation with a zonal rotor2023

    • Author(s)
      Wada M, Uchida N, Posadas-Herrera G, Hayashita-Kinoh H, Tsunekawa Y, Hirai Y, Okada T.
    • Journal Title

      Gene Therapy

      Volume: Mar 28 Issue: 7-8 Pages: 641-648

    • DOI

      10.1038/s41434-023-00398-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K20328, KAKENHI-PROJECT-22K06064, KAKENHI-PROJECT-20K06464
  • [Journal Article] Engineering a highly durable adeno-associated virus receptor for analytical applications2023

    • Author(s)
      Yoshida Kouhei、Tsunekawa Yuji、Kurihara Kento、Watanabe Kazuya、Makino-Manabe Yuriko、Wada Mikako、Tanaka Toru、Ide Teruhiko、Okada Takashi
    • Journal Title

      Molecular Therapy - Methods & Clinical Development

      Volume: 31 Pages: 101157-101157

    • DOI

      10.1016/j.omtm.2023.101157

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K06464, KAKENHI-PROJECT-23K20328
  • [Journal Article] In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration.2016

    • Author(s)
      Suzuki K, Tsunekawa Y, Hernandez-Benitez R, Wu J, Zhu J, Kim EJ, Hatanaka F, Yamamoto M, Araoka T, Li Z, Kurita M, Hishida T, Li M, Aizawa E, Guo S, Chen S, Goebl A, Soligalla RD, Qu J, Jiang T, Fu X, ---, Belmonte JC.
    • Journal Title

      Nature

      Volume: 540(7631) Issue: 7631 Pages: 144-149

    • DOI

      10.1038/nature20565

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K18382
  • [Journal Article] Developing a De Novo Targeted Knock-in Method Based on in Utero Electroporation Into the Mammalian Brain2016

    • Author(s)
      Tsunekawa, Yuji, Raymond Kunikane Terhune, Ikumi Fujita, Atsunori Shitamukai, Taeko Suetsugu, Fumio Matsuzaki
    • Journal Title

      Development

      Volume: 143 Issue: 17 Pages: 3216-3222

    • DOI

      10.1242/dev.136325

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16K18381, KAKENHI-PROJECT-16K18382, KAKENHI-PROJECT-16K21627
  • [Patent] ウイルスの精製方法2022

    • Inventor(s)
      恒川雄二
    • Industrial Property Rights Holder
      恒川雄二
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2022-047745
    • Filing Date
      2022
    • Data Source
      KAKENHI-PROJECT-20K06464
  • [Patent] ポリヌクレオチドおよびその利用2019

    • Inventor(s)
      恒川雄二
    • Industrial Property Rights Holder
      恒川雄二
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Data Source
      KAKENHI-PROJECT-18K19311
  • [Patent] US provisional application 62/363,1642016

    • Inventor(s)
      Yuji Tsunekawa
    • Industrial Property Rights Holder
      Yuji Tsunekawa
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-07-15
    • Overseas
    • Data Source
      KAKENHI-PROJECT-16K18382
  • [Presentation] Developing de novo genome editing meyhods2017

    • Author(s)
      恒川雄二
    • Organizer
      Conbio2017
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K18382
  • 1.  宮道 和成 (30612577)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  岡田 尚巳 (00326828)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  松坂 恭成 (60420949)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  喜納 裕美 (60532728)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 5.  笠原 優子 (90391911)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  曽田 泰 (00361618)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  岡田 尚已
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  下向 敦範
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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