Tsunekawa Yuji 恒川雄二

… Alternative Names

Yuji Tsunekawa 恒川雄二

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Researcher Number	80733352
Other IDs
Affiliation (Current)	2025: 東京大学, 医科学研究所, 助教
Affiliation (based on the past Project Information) *help	2020 – 2025: 東京大学, 医科学研究所, 助教 2018 – 2019: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 研究員 2016 – 2017: 国立研究開発法人理化学研究所, 多細胞システム形成研究センター, 研究員
Review Section/Research Field	Principal Investigator Basic Section 43060:System genome science-related / Basic Section 42040:Laboratory animal science-related / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Nerve anatomy/Neuropathology Except Principal Investigator Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
Keywords	Principal Investigator Cre de novo ノックイン / HBoV vector / リコンビネース / ノックイン / Creノックイン / LsCre / AAV / LsCreの開発 / LeaklessCre / de novo Cre knock-in … More / 複雑脳の発生 / de novoノックイン技術の開発 / 複雑脳におけるAscl1の機能解析 / de novo Cre KI / 複雑脳発生 … More Except Principal Investigator MSC / AAV / 遺伝子治療 Less

組織特異的ヒトボカウイルスベクターの開発Principal Investigator
- Principal Investigator
  
  恒川雄二
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43060:System genome science-related
- Research Institution
  The University of Tokyo
アデノ随伴ウイルスベクター基盤技術開発と脳神経疾患に対する遺伝子細胞療法
- Principal Investigator
  
  岡田尚巳
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  The University of Tokyo
Development of novel recombinant enzyme for understanding complex brain developmentPrincipal Investigator
- Principal Investigator
  
  Tsunekawa Yuji
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  The University of Tokyo
Developing new Cre-loxp system for all organismPrincipal Investigator
- Principal Investigator
  
  Tsunekawa Yuji
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Institute of Physical and Chemical Research
Study of molecular mechanism of complex brain by ferretPrincipal Investigator
- Principal Investigator
  
  Yuji Tsunekawa
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Institute of Physical and Chemical Research

All 2023 2022 2019 2017 2016

All Journal Article Presentation Patent

[Journal Article] Subcellular mRNA localization and local translation of Arhgap11a in radial glial progenitors regulates cortical development2023
- Author(s)
  Pilaz LJ, Liu J, Joshi K, Tsunekawa Y, Musso CM, D'Arcy BR, Suzuki IK, Alsina FC, Kc P, Sethi S, Vanderhaeghen P, Polleux F, Silver DL.
- Journal Title
  
  Neuron .
  
  Volume: 111(6) Issue: 6 Pages: 839-856
- DOI
  10.1016/j.neuron.2023.02.023
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06464, KAKENHI-PROJECT-23K23891
[Journal Article] Development of a novel purification method for AAV vectors using tangential flow filtration2023
- Author(s)
  Miyaoka Rimi、Tsunekawa Yuji、Kurosawa Yae、Sasaki Takako、Onodera Azusa、Sakamoto Kenji、Kakiuchi Yuko、Wada Mikako、Nitahara‐Kasahara Yuko、Hayashita‐Kinoh Hiromi、Okada Takashi
- Journal Title
  
  Biotechnology and Bioengineering
  
  Volume: 120 Issue: 11 Pages: 3311-3321
- DOI
  10.1002/bit.28524
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06064, KAKENHI-PROJECT-22K06921, KAKENHI-PROJECT-20K06464, KAKENHI-PROJECT-23K20328
[Journal Article] Large-scale purification of functional AAV particles packaging the full genome using short-term ultracentrifugation with a zonal rotor2023
- Author(s)
  Wada M, Uchida N, Posadas-Herrera G, Hayashita-Kinoh H, Tsunekawa Y, Hirai Y, Okada T.
- Journal Title
  
  Gene Therapy
  
  Volume: Mar 28 Issue: 7-8 Pages: 641-648
- DOI
  10.1038/s41434-023-00398-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K20328, KAKENHI-PROJECT-22K06064, KAKENHI-PROJECT-20K06464
[Journal Article] Engineering a highly durable adeno-associated virus receptor for analytical applications2023
- Author(s)
  Yoshida Kouhei、Tsunekawa Yuji、Kurihara Kento、Watanabe Kazuya、Makino-Manabe Yuriko、Wada Mikako、Tanaka Toru、Ide Teruhiko、Okada Takashi
- Journal Title
  
  Molecular Therapy - Methods & Clinical Development
  
  Volume: 31 Pages: 101157-101157
- DOI
  10.1016/j.omtm.2023.101157
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06464, KAKENHI-PROJECT-23K20328
[Journal Article] In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration.2016
- Author(s)
  Suzuki K, Tsunekawa Y, Hernandez-Benitez R, Wu J, Zhu J, Kim EJ, Hatanaka F, Yamamoto M, Araoka T, Li Z, Kurita M, Hishida T, Li M, Aizawa E, Guo S, Chen S, Goebl A, Soligalla RD, Qu J, Jiang T, Fu X, ---, Belmonte JC.
- Journal Title
  
  Nature
  
  Volume: 540(7631) Issue: 7631 Pages: 144-149
- DOI
  10.1038/nature20565
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18382
[Journal Article] Developing a De Novo Targeted Knock-in Method Based on in Utero Electroporation Into the Mammalian Brain2016
- Author(s)
  Tsunekawa, Yuji, Raymond Kunikane Terhune, Ikumi Fujita, Atsunori Shitamukai, Taeko Suetsugu, Fumio Matsuzaki
- Journal Title
  
  Development
  
  Volume: 143 Issue: 17 Pages: 3216-3222
- DOI
  10.1242/dev.136325
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K18381, KAKENHI-PROJECT-16K18382, KAKENHI-PROJECT-16K21627
[Patent] ウイルスの精製方法2022
- Inventor(s)
  恒川雄二
- Industrial Property Rights Holder
  恒川雄二
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-047745
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-20K06464
[Patent] ポリヌクレオチドおよびその利用2019
- Inventor(s)
  恒川雄二
- Industrial Property Rights Holder
  恒川雄二
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-18K19311
[Patent] US provisional application 62/363,1642016
- Inventor(s)
  Yuji Tsunekawa
- Industrial Property Rights Holder
  Yuji Tsunekawa
- Industrial Property Rights Type
  特許
- Filing Date
  2016-07-15
- Overseas
- Data Source
  KAKENHI-PROJECT-16K18382
[Presentation] Developing de novo genome editing meyhods2017
- Author(s)
  恒川雄二
- Organizer
  Conbio2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18382

1. 宮道和成 (30612577)

# of Collaborated Projects: 1 results

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2. 岡田尚巳 (00326828)

# of Collaborated Projects: 1 results

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3. 曽田泰 (00361618)

# of Collaborated Projects: 1 results

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4. 喜納裕美 (60532728)

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5. 笠原優子 (90391911)

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6. 松坂恭成 (60420949)

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7. 伊東潤平 (20835540)

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8. 山口貴世志 (50466843)

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9. 岡田尚已

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10. 下向敦範

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# of Collaborated Products: 1 results

Tsunekawa Yuji 恒川 雄二

Yuji Tsunekawa 恒川 雄二

Research Projects

Research Products

Co-Researchers

組織特異的ヒトボカウイルスベクターの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

アデノ随伴ウイルスベクター基盤技術開発と脳神経疾患に対する遺伝子細胞療法

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel recombinant enzyme for understanding complex brain developmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Developing new Cre-loxp system for all organismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of molecular mechanism of complex brain by ferretPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Subcellular mRNA localization and local translation of Arhgap11a in radial glial progenitors regulates cortical development2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of a novel purification method for AAV vectors using tangential flow filtration2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Large-scale purification of functional AAV particles packaging the full genome using short-term ultracentrifugation with a zonal rotor2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Engineering a highly durable adeno-associated virus receptor for analytical applications2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Developing a De Novo Targeted Knock-in Method Based on in Utero Electroporation Into the Mammalian Brain2016

Author(s)

Journal Title

DOI

Data Source

[Patent] ウイルスの精製方法2022

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Patent] ポリヌクレオチドおよびその利用2019

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Patent] US provisional application 62/363,1642016

Inventor(s)

Tsunekawa Yuji 恒川雄二

Yuji Tsunekawa 恒川雄二