Takahara Masahiro 高原政宏

Researcher Number	80738427
Other IDs
Affiliation (Current)	2026: 岡山大学, 異分野融合教育研究領域, 特任助教
Affiliation (based on the past Project Information) *help	2023 – 2024: 岡山大学, 大学病院, 助教 2022: 岡山大学, 医歯薬学域, 助教 2021: 岡山大学, 大学病院, 医員 2020: 岡山大学, 医学部, 客員研究員 2019: 岡山大学, 大学病院, 医員 2018: 岡山大学, 大学病院, 助教 2015 – 2017: 岡山大学, 医学部, 客員研究員
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Immunology Except Principal Investigator Basic Section 90130:Medical systems-related / Basic Section 53010:Gastroenterology-related / Gastroenterology
Keywords	Principal Investigator 炎症性腸疾患 / CD4 T cell / IBD / 腸管粘膜CD4T細胞 / 酸化的リン酸化 / ミトコンドリア / CD4 T細胞 / メトホルミン / 腸内細菌叢 / LPCD4T細胞 … More / AMPK / エネルギー代謝 / 腸管粘膜CD4T+細胞 / CD4 + T細胞 / 制御性T細胞 / CD4+T細胞 / CD25 … More Except Principal Investigator 潰瘍性大腸炎 / 免疫学的便潜血反応 / 在宅自己測定 / セルフマネジメント / 免疫学的便潜血検査 / セントラルメモリーT細胞 / 抗体製剤 / 直腸粘膜リンパ球 / フローサイトメトリー / 在宅自己管理検査システム / 内科 / 細菌 / 腸内細菌叢解析 / 腸内環境 / 腸内細菌叢 / 膵癌 Less

Construction of a home fecal immunochemical test for self-management in patients with ulcerative colitis
- Principal Investigator
  
  平岡佐規子
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90130:Medical systems-related
- Research Institution
  Okayama University
Establishment of a Method to Predict Therapeutic Response Based on Surface Marker Expression of Rectal Lymphocytes in Ulcerative Colitis Patients
- Principal Investigator
  
  Iwamuro Masaya
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Okayama University
Investigation of the usefulness of home-based measurement of fecal immunochemical test in patients with ulcerative colitis.
- Principal Investigator
  
  Hiraoka Sakiko
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90130:Medical systems-related
- Research Institution
  Okayama University
Development of novel therapeutic agent for inflammatory bowel disease targeting the regulation of CD4 T cell metabolismPrincipal Investigator
- Principal Investigator
  
  Takahara Masahiro
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Okayama University
Investigating intestinal environments as risks for pancreatico-biliary cancers
- Principal Investigator
  
  Takaki Akinobu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Okayama University
Can the cell surface marker detected by our new culture system be a therapeutic target for inflammatory bowel disease (IBD)?Principal Investigator
- Principal Investigator
  
  Takahara Masahiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Okayama University

All 2025 2024 2022 2021

All Journal Article Presentation

[Journal Article] Induction Therapy With Oral Tacrolimus Provides Long‐Term Benefit in Thiopurine‐Naive Refractory Ulcerative Colitis Patients Despite Low Serum Albumin Levels2025
- Author(s)
  Igawa Shoko、Inokuchi Toshihiro、Hiraoka Sakiko、Toyosawa Junki、Aoyama Yuki、Yamasaki Yasushi、Kinugasa Hideaki、Takahara Masahiro、Okada Hiroyuki、Otsuka Motoyuki
- Journal Title
  
  JGH Open
  
  Volume: 9 Issue: 4
- DOI
  10.1002/jgh3.70139
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K11871
[Journal Article] Changes of leucine-rich alpha 2 glycoprotein could be a marker of changes of endoscopic and histologic activity of ulcerative colitis2025
- Author(s)
  Aoyama Yuki、Hiraoka Sakiko、Yasutomi Eriko、Inokuchi Toshihiro、Tanaka Takehiro、Takei Kensuke、Igawa Shoko、Takeuchi Keiko、Takahara Masahiro、Toyosawa Junki、Yamasaki Yasushi、Kinugasa Hideaki、Kato Jun、Okada Hiroyuki、Otsuka Motoyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 15 Issue: 1 Pages: 5248-5248
- DOI
  10.1038/s41598-025-89615-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K11871
[Journal Article] Decreased CD3+CD56+ Natural Killer T Lymphocytes and Increased Human Leukocyte Antigen-DR+ Cells in the Inflamed Area of Pouchitis in Ulcerative Colitis Patients2024
- Author(s)
  Iwamuro M, Tanaka T, Takahara M, Inokuchi T, Hiraoka S
- Journal Title
  
  Cureus
  
  Volume: 16(9)
- DOI
  10.7759/cureus.70066
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07962
[Journal Article] Metformin ameliorates chronic colitis in a mouse model by regulating. interferon-γ-producing lamina. propria CD4 + T cells through AMPK activation2022
- Author(s)
  Takahara Masahiro
- Journal Title
  
  FASEB
  
  Volume: Feb;36(2) Issue: 2
- DOI
  10.1096/fj.202100831rr
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16957, KAKENHI-PROJECT-21K19409, KAKENHI-PROJECT-18H04033
[Presentation] ACCURACY AND FEASIBILITY OF HOME－BASED MEASUREMENT OF FECAL IMMUNOCHEMICAL TEST IN PATIENTS WITH ULCERATIVE COLITIS2025
- Author(s)
  Y. AOYAMA , T. INOKUCHI , S. HIRAOKA , M. ISHIGURO , S. IGAWA , K. TAKEUCHI 1, M. TAKAHARA , J. TOYOSAWA , Y. YAMASAKI , H. KINUGASA and M. OTSUKA
- Organizer
  DDW 2025
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K11871
[Presentation] エネルギー代謝をターゲットにした炎症性腸疾患治療の可能性2022
- Author(s)
  高原政宏
- Organizer
  第108回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-20K16957
[Presentation] メトホルミンは腸管粘膜CD4+T細胞のAMPKの活性化を介してIFN-γを制御しマウス慢性腸炎を改善させる2021
- Author(s)
  高原政宏
- Organizer
  第58回日本消化器免疫学会総会
- Data Source
  KAKENHI-PROJECT-20K16957

1. Hiraoka Sakiko (90397894)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
2. Takaki Akinobu (80359885)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. Iwamuro Masaya (30645403)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 森田英利 (70257294)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 松本和幸 (40795027)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 白羽英則 (40379748)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 井口俊博 (90975153)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results

Takahara Masahiro 高原 政宏

Research Projects

Research Products

Co-Researchers

Construction of a home fecal immunochemical test for self-management in patients with ulcerative colitis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of a Method to Predict Therapeutic Response Based on Surface Marker Expression of Rectal Lymphocytes in Ulcerative Colitis Patients

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of the usefulness of home-based measurement of fecal immunochemical test in patients with ulcerative colitis.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel therapeutic agent for inflammatory bowel disease targeting the regulation of CD4 T cell metabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigating intestinal environments as risks for pancreatico-biliary cancers

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Can the cell surface marker detected by our new culture system be a therapeutic target for inflammatory bowel disease (IBD)?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Induction Therapy With Oral Tacrolimus Provides Long‐Term Benefit in Thiopurine‐Naive Refractory Ulcerative Colitis Patients Despite Low Serum Albumin Levels2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Changes of leucine-rich alpha 2 glycoprotein could be a marker of changes of endoscopic and histologic activity of ulcerative colitis2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Decreased CD3+CD56+ Natural Killer T Lymphocytes and Increased Human Leukocyte Antigen-DR+ Cells in the Inflamed Area of Pouchitis in Ulcerative Colitis Patients2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Metformin ameliorates chronic colitis in a mouse model by regulating. interferon-γ-producing lamina. propria CD4 + T cells through AMPK activation2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] ACCURACY AND FEASIBILITY OF HOME－BASED MEASUREMENT OF FECAL IMMUNOCHEMICAL TEST IN PATIENTS WITH ULCERATIVE COLITIS2025

Author(s)

Organizer

Data Source

[Presentation] エネルギー代謝をターゲットにした炎症性腸疾患治療の可能性2022

Author(s)

Organizer

Data Source

[Presentation] メトホルミンは腸管粘膜CD4+T細胞のAMPKの活性化を介してIFN-γを制御しマウス慢性腸炎を改善させる2021

Author(s)

Organizer

Data Source

Takahara Masahiro 高原政宏