Hara Satoshi 原聡史

Researcher Number	80739582
Other IDs
Affiliation (Current)	2026: 佐賀大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2026: 佐賀大学, 医学部, 助教 2019 – 2024: 佐賀大学, 医学部, 助教 2015 – 2018: 国立研究開発法人国立成育医療研究センター, システム発生・再生医学研究部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 42030:Animal life science-related / Human genetics / System genome science Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Medium-sized Section 48:Biomedical structure and function and related fields
Keywords	Principal Investigator ゲノム編集 / ゲノムインプリンティング / CRISPR/Cas9 / IG-DMR / Dlk1-Dio3ドメイン / Beckwith-Wiedemann症候群 / Igf2-H19 / 2細胞期インジェクション / エピジェネティクス / 遺伝学 / ヒト-マウス配列置換 / ゲノムインプリント … More Except Principal Investigator … More 空間遺伝子発現 / 一細胞マルチオミクス / ヘテロ欠損マウス / ソトス症候群 / NSD1 / 核－細胞質間物質輸送 / 不妊症 / Importin / 配偶子形成 / 核輸送 / 卵 / 女性不妊症 / クロマチン / インポーティン / 卵発生 / 精子細胞形成 / 細胞核輸送 Less

ICR1異常高メチル化を可視化するマウスを用いたモザイク形成機構の解明Principal Investigator
- Principal Investigator
  
  原聡史
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  Saga University
Elucidation of molecular pathogenesis and establishment of therapeutic foundations for intellectual disabilities based on single-cell multiomics and spatial gene expression
- Principal Investigator
  
  副島英伸
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Saga University
Investigation of molecular mechanisms for overgrowth and aberrant hypermethylation using H19-ICR mutant mouse panelPrincipal Investigator
- Principal Investigator
  
  原聡史
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  Saga University
Exploring a novel function of nuclear transport molecules in male and female gametogenesis and elucidation of the infertility mechanism
- Principal Investigator
  
  宮本洋一
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 48:Biomedical structure and function and related fields
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition
Exploration of the responsible sequence causing perinatal lethality in mice with maternal deletion of IG-DMRPrincipal Investigator
- Principal Investigator
  
  Hara Satoshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  Saga University
Regulatory mechanisms of human IG-DMR in knock-in micePrincipal Investigator
- Principal Investigator
  
  Hara Satoshi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human genetics
- Research Institution
  National Center for Child Health and Development
Mechanisms of DNA repair involved in the genome editing efficiencies in mouse zygotesPrincipal Investigator
- Principal Investigator
  
  Hara Satoshi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  System genome science
- Research Institution
  National Center for Child Health and Development

All 2025 2024 2021 2020 2019 2018 2017

All Journal Article Presentation Book

[Book] トンプソン&トンプソン遺伝医学・ゲノム医学　第３版2025
- Author(s)
  副島英伸、原聡史、一丸武作志
- Total Pages
  735
- Publisher
  メディカル・サイエンス・インターナショナル
- ISBN
  9784815731250
- Data Source
  KAKENHI-PROJECT-24K02422
[Journal Article] Identification of responsible sequences which mutations cause maternal H19-ICR hypermethylation with Beckwith?Wiedemann syndrome-like overgrowth2024
- Author(s)
  Hara Satoshi、Matsuhisa Fumikazu、Kitajima Shuji、Yatsuki Hitomi、Kubiura-Ichimaru Musashi、Higashimoto Ken、Soejima Hidenobu
- Journal Title
  
  Communications Biology
  
  Volume: 7 Issue: 1 Pages: 1605-1605
- DOI
  10.1038/s42003-024-07323-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24K02422, KAKENHI-PROJECT-24K18373
[Journal Article] Importin α4 deficiency induces psychiatric disorder-related behavioral deficits and neuroinflammation in mice2024
- Author(s)
  Sakurai Koki、Morita Makiko、Aomine Yoshiatsu、Matsumoto Mitsunobu、Moriyama Tetsuji、Kasahara Emiko、Sekiyama Atsuo、Otani Mayumi、Oshima Rieko、Loveland Kate L.、Yamada Masami、Yoneda Yoshihiro、Oka Masahiro、Hikida Takatoshi、Miyamoto Yoichi
- Journal Title
  
  Translational Psychiatry
  
  Volume: 14 Issue: 1 Pages: 426-426
- DOI
  10.1038/s41398-024-03138-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24205, KAKENHI-PROJECT-23K27373, KAKENHI-PROJECT-24K09446, KAKENHI-PROJECT-23K18163, KAKENHI-PROJECT-24KJ1604, KAKENHI-PROJECT-22KK0111
[Journal Article] Comprehensive molecular and clinical findings in 29 patients with multi-locus imprinting disturbance2024
- Author(s)
  Urakawa T, Soejima H, Yamoto K, Hara-Isono K, Nakamura A, Kawashima S, Narusawa H, Kosaki R, Nishimura Y, Yamazawa K, Hattori T, Muramatsu Y, Inoue T, Matsubara K, Fukami M, Saitoh S, Ogata T, Kagami M
- Journal Title
  
  Clinical Epigenetics
  
  Volume: 16 Issue: 1 Pages: 138-138
- DOI
  10.1186/s13148-024-01744-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24309, KAKENHI-PROJECT-22K07858, KAKENHI-PROJECT-21K19751, KAKENHI-PROJECT-24K02422
[Journal Article] Humanization of a tandem repeat in IG-DMR causes stochastic restoration of paternal imprinting at mouse<i>Dlk1</i>-<i>Dio3</i>domain2021
- Author(s)
  Hara Satoshi、Terao Miho、Tsuji-Hosokawa Atsumi、Ogawa Yuya、Takada Shuji
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 30 Issue: 7 Pages: 564-574
- DOI
  10.1093/hmg/ddab071
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06451
[Journal Article] Phenotypically concordant but epigenetically discordant monozygotic dichorionic diamniotic twins with Beckwith?Wiedemann syndrome2021
- Author(s)
  Sun Feifei、Hara Satoshi、Tomita Chiyoko、Tanoue Yuka、Yatsuki Hitomi、Higashimoto Ken、Soejima Hidenobu
- Journal Title
  
  American Journal of Medical Genetics Part A
  
  Volume: 185 Issue: 10 Pages: 3062-3067
- DOI
  10.1002/ajmg.a.62364
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06451, KAKENHI-PROJECT-20H03643, KAKENHI-PROJECT-20K08183, KAKENHI-PROJECT-21K19451
[Journal Article] Efficient production and transmission of CRISPR/Cas9-mediated mutant alleles at the IG-DMR via generation of mosaic mice using a modified 2CC method2019
- Author(s)
  Hara Satoshi、Terao Miho、Muramatsu Akari、Takada Shuji
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 20202-20202
- DOI
  10.1038/s41598-019-56676-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06451
[Journal Article] A tandem repeat array in IG-DMR is essential for imprinting of paternal allele at the Dlk1/Dio3 domain during embryonic development.2018
- Author(s)
  Saito T, Hara S, Kato T, Tamano M, Muramatsu A, Asahara H and Takada S.
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 27 Issue: 18 Pages: 3283-3292
- DOI
  10.1093/hmg/ddy235
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21664, KAKENHI-PROJECT-17K18403
[Presentation] ゲノムワイド父性片親性ヘテロダイソミーを示す核型46,XYのBeckwith-Wiedemannスペクトラムの一例．2025
- Author(s)
  副島英伸、佐藤知彦、一丸（首浦）武作志、原聡史．
- Organizer
  第47回日本小児遺伝学会学術集会
- Data Source
  KAKENHI-PROJECT-24K02422
[Presentation] NSD1ヘテロ欠損はマウス新生児生存率を低下させる．2024
- Author(s)
  一丸（首浦）武作志、原聡史、八木ひとみ、副島英伸．
- Organizer
  第47回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-24K02422
[Presentation] Exome sequencing reveals causative variants for overgrowth syndromes in molecularly negative Beckwith-Wiedemann spectrum.2024
- Author(s)
  副島英伸、東元健、孫菲菲、今川英里、才田謙、三宅紀子、原聡史、八木ひとみ、一丸（首浦）武作志、藤田京志、水口剛、松本直通．
- Organizer
  日本人類遺伝学会第69回大会
- Data Source
  KAKENHI-PROJECT-24K02422
[Presentation] 海外でNIPTを受検した夫婦のカウンセリング経験．2024
- Author(s)
  山本徒子、津田聡子、栗原麻希子、副島英伸．
- Organizer
  第30回出生前から小児期にわたるゲノム医療フォーラム
- Data Source
  KAKENHI-PROJECT-24K02422
[Presentation] ゲノムワイド父性片親性ヘテロダイソミーを示す核型46,XYのBeckwith-Wiedemannスペクトラムの一例．2024
- Author(s)
  原聡史、佐藤知彦、一丸武作志、副島英伸．
- Organizer
  第47回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-24K02422
[Presentation] NSD1ヘテロ欠損が胎仔・新生仔に与える影響．2024
- Author(s)
  一丸（首浦）武作志、原聡史、八木ひとみ、東元健、副島英伸．
- Organizer
  第17回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-24K02422
[Presentation] マウスIG-DMRの母方アレルにおけるインプリント制御領域のスクリーニング2021
- Author(s)
  原聡史、村松あかり、寺尾美穂、高田修治
- Organizer
  第14回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-19K06451
[Presentation] マウスIG-DMRの母方アレルにおけるインプリント制御領域のスクリーニング2020
- Author(s)
  原聡史、村松あかり、寺尾美穂、高田修治
- Organizer
  第113回日本繁殖生物学会年会
- Data Source
  KAKENHI-PROJECT-19K06451
[Presentation] 2細胞期胚へのインジェクションによるインプリント制御領域IG-DMRへのゲノム編集2019
- Author(s)
  原聡史、寺尾美穂、村松あかり、高田修治
- Organizer
  第42回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-19K06451
[Presentation] ヒト-マウス間におけるIG-DMRによるインプリント制御機構の違い2018
- Author(s)
  原聡史、高田修治
- Organizer
  第41回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-17K18403
[Presentation] 欠失および配列置換マウスを用いたIG-DMRによる発現制御機構の解析2018
- Author(s)
  原聡史、村松あかり、高田修治
- Organizer
  第111回日本繁殖生物学会
- Data Source
  KAKENHI-PROJECT-17K18403
[Presentation] 配列置換マウスを用いたDlk1-Dio3領域におけるインプリント制御配列の機能解析2017
- Author(s)
  原聡史、齋藤剛志、高田修治
- Organizer
  第11回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-17K18403

1. 宮本洋一 (10379084)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 岡田由紀 (60546430)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 小井土大 (40787561)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 副島英伸 (30304885)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
5. 首浦武作志 (20827977)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
6. HIKIDA Takatoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. YAMAZAWA Kazuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. KAGAMI Masayo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. MATSUBARA Keiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 加藤朋子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hara Satoshi 原 聡史

Research Projects

Research Products

Co-Researchers

ICR1異常高メチル化を可視化するマウスを用いたモザイク形成機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of molecular pathogenesis and establishment of therapeutic foundations for intellectual disabilities based on single-cell multiomics and spatial gene expression

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of molecular mechanisms for overgrowth and aberrant hypermethylation using H19-ICR mutant mouse panelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploring a novel function of nuclear transport molecules in male and female gametogenesis and elucidation of the infertility mechanism

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploration of the responsible sequence causing perinatal lethality in mice with maternal deletion of IG-DMRPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulatory mechanisms of human IG-DMR in knock-in micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms of DNA repair involved in the genome editing efficiencies in mouse zygotesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] トンプソン&トンプソン 遺伝医学・ゲノム医学 第３版2025

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Identification of responsible sequences which mutations cause maternal H19-ICR hypermethylation with Beckwith?Wiedemann syndrome-like overgrowth2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Importin α4 deficiency induces psychiatric disorder-related behavioral deficits and neuroinflammation in mice2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comprehensive molecular and clinical findings in 29 patients with multi-locus imprinting disturbance2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Humanization of a tandem repeat in IG-DMR causes stochastic restoration of paternal imprinting at mouse<i>Dlk1</i>-<i>Dio3</i>domain2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phenotypically concordant but epigenetically discordant monozygotic dichorionic diamniotic twins with Beckwith?Wiedemann syndrome2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Efficient production and transmission of CRISPR/Cas9-mediated mutant alleles at the IG-DMR via generation of mosaic mice using a modified 2CC method2019

Author(s)

Journal Title

Hara Satoshi 原聡史

[Book] トンプソン&トンプソン遺伝医学・ゲノム医学　第３版2025