SHINOHARA Tamao 篠原珠緒

Researcher Number	80747452
Affiliation (Current)	2023: 山梨大学, 大学院総合研究部, 医学研究員
Affiliation (based on the past Project Information) *help	2017 – 2021: 山梨大学, 大学院総合研究部, 医学研究員
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related Except Principal Investigator Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related
Keywords	Principal Investigator 微小残存病変 / メチル化 / 急性白血病 / 小児急性リンパ性白血病 / 遺伝子メチル化 / 血液悪性腫瘍 Except Principal Investigator 急性リンパ性白血病 / 薬剤感受性 / ゲノム編集 / 化学療法 … More / 遺伝子変異 / 一塩基多型 / 白血病 / 遺伝子多型 / 薬剤耐性 / 難治性 / 個別化治療 / がんゲノム Less

Integrated study aiming at development of precision medicine for poor prognostic acute lymphoblastic leukemia
- Principal Investigator
  
  Inukai Takeshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  University of Yamanashi
小児急性ALLにおけるメチル化率のMRD解析への応用Principal Investigator
- Principal Investigator
  
  篠原珠緒
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  University of Yamanashi
Establishment of ALL cell line bank to identify genetic factors involving in drug-sensitivity for future precision medicine
- Principal Investigator
  
  INUKAI Takeshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  University of Yamanashi

All 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Successful treatment of intractable gastrointestinal tract graft-vs-host disease with oral beclomethasone dipropionate in pediatric and young adult patients2022
- Author(s)
  Akahane Koshi、Watanabe Atsushi、Somazu Shinpei、Harama Daisuke、Shinohara Tamao、Kasai Shin、Oshiro Hiroko、Goi Kumiko、Hasuda Norio、Ozawa Chihiro、Sugita Kanji、Inukai Takeshi
- Journal Title
  
  Medicine
  
  Volume: 101
- DOI
  10.1097/md.0000000000029054
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03615
[Journal Article] Association of allele-specific methylation of the ASNS gene with asparaginase sensitivity and prognosis in T-ALL.2022
- Author(s)
  Akahane Koshi、Kimura Shunsuke、Miyake Kunio、Watanabe Atsushi、Kagami Keiko、Yoshimura Kentaro、Shinohara Tamao、Harama Daisuke、Kasai Shin、Goi Kumiko、Kawai Tomoko、Hata Kenichiro、Kiyokawa Nobutaka、Koh Katsuyoshi、他7名
- Journal Title
  
  Blood Adv
  
  Volume: 6 Pages: 212-224
- DOI
  10.1182/bloodadvances.2021004271
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07728, KAKENHI-PROJECT-20K21707, KAKENHI-PROJECT-20H00528, KAKENHI-PROJECT-19H03615, KAKENHI-PROJECT-20H03928, KAKENHI-PROJECT-21K19405
[Journal Article] NUDT15 polymorphism and NT5C2 and PRPS1 mutations influence thiopurine sensitivity in acute lymphoblastic leukaemia cells2021
- Author(s)
  Somazu S, Tanaka Y, Tamai M, Watanabe A, Kagami K, Abe M, Harama D, Shinohara T, Akahane K, Goi K, Sugita K, Moriyama T, Yang J, Goto H, Minegishi M, Iwamoto S,?Takita J, Inukai T
- Journal Title
  
  Journal of Cellular and Molecular Medicine
  
  Volume: 25 Pages: 10521-10533
- DOI
  10.1111/jcmm.16981
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00528, KAKENHI-PROJECT-19H03615, KAKENHI-PROJECT-21K19405
[Journal Article] Association of aberrant ASNS imprinting with asparaginase sensitivity and chromosomal abnormality in childhood BCP-ALL.2020
- Author(s)
  Atsushi Watanabe, Kunio Miyake, Jessica Nordlund, Ann-Christine Syvanen, Louise van der Weyden, Hiroaki Honda, Norimasa Yamasaki, Akiko Nagamachi, Toshiya Inaba, Tomokatsu Ikawa, Kevin Y Urayama, Nobutaka Kiyokawa, Akira Ohara, Shunsuke Kimura, Yasuo Kubota, Junko Takita, Hiroaki Goto, Kimiyoshi Sakaguchi, et al.
- Journal Title
  
  Blood
  
  Volume: 136 Pages: 2319-2333
- DOI
  10.1182/blood.2019004090
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08318, KAKENHI-PROJECT-19K22546, KAKENHI-PROJECT-20K21707, KAKENHI-PROJECT-19KK0222, KAKENHI-PROJECT-18H02838, KAKENHI-PROJECT-19H03615, KAKENHI-PROJECT-19H03693, KAKENHI-PROJECT-20H03928, KAKENHI-PROJECT-18K08357, KAKENHI-PROJECT-20H00528
[Journal Article] Association of relapse-linked ARID5B single nucleotide polymorphisms with drug resistance in B-cell precursor acute lymphoblastic leukemia cell lines.2020
- Author(s)
  Tamai M, Huang M, Kagami K, Abe M, Somazu S, Shinohara T, Harama D, Watanabe A, Akahane K, Goi K, Sugita K, Goto H, Minegishi M, Iwamoto S, Inukai T.
- Journal Title
  
  Cancer Cell Int
  
  Volume: 20 Pages: 434-434
- DOI
  10.1186/s12935-020-01524-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03615
[Journal Article] Inherited genetic variants associated with glucocorticoid sensitivity in leukaemia cells.2020
- Author(s)
  Shinohara T, Urayama KY, Watanabe A, Akahane K, Goi K, Huang M, Kagami K, Abe M, Sugita K, Okada Y, Goto H, Minegishi M, Iwamoto S, Inukai T.
- Journal Title
  
  J Cell Mol Med
  
  Volume: 24 Pages: 12920-12932
- DOI
  10.1111/jcmm.15882
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03615
[Journal Article] High ENT1 and DCK gene expression levels are a potential biomarker to predict favorable response to nelarabine therapy in T‐cell acute lymphoblastic leukemia2019
- Author(s)
  Akahane K, Murakami Y, Kagami K, Abe M, Harama D, Shinohara T, Watanabe A, Goi K, Nishi R, Yamauchi T, Kimura S, Takita J, Look AT, Minegishi M, Sugita K, Inukai T.
- Journal Title
  
  Hematological Oncology
  
  Volume: 37 Pages: 516-519
- DOI
  10.1002/hon.2654
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07294, KAKENHI-PROJECT-17H04224, KAKENHI-PROJECT-19H03615, KAKENHI-PROJECT-18K19467
[Journal Article] Resistance of t(17;19)‐acute lymphoblastic leukemia cell lines to multiagents in induction therapy2019
- Author(s)
  Watanabe A, Inukai T, Kagami K, Abe M, Takagi M, Fukushima T, Fukushima H, Nanmoku T, Terui K, Ito T, Toki T, Ito E, Fujimura J, Goto H, Endo M, Look T, Kamps M, Minegishi M, Takita J, Inaba T, Takahashi H, Ohara A, Harama D, Shinohara T, Somazu S, Oshiro H, Akahane K, Goi K, Sugita K.
- Journal Title
  
  Cancer Medicine
  
  Volume: 7 Pages: 5274-5288
- DOI
  10.1002/cam4.2356
- NAID
  120007159553
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04039, KAKENHI-PROJECT-17H04224, KAKENHI-PROJECT-18H02838, KAKENHI-PROJECT-19H03615, KAKENHI-PROJECT-18K19467
[Journal Article] Splicing variant profiles and single nucleotide polymorphisms of the glucocorticoid receptor gene in relation to glucocorticoid sensitivity of B-cell precursor acute lymphoblastic leukaemia.2018
- Author(s)
  Huang M, Inukai T, Kagami K, Abe M, Shinohara T, Watanabe A, Somazu S, Oshiro H, Goi K, Goto H, Minegishi M, Iwamoto S, Urayama KY, Sugita K.
- Journal Title
  
  Hematol Oncol.
  
  Volume: 36(1) Pages: 245-251
- DOI
  10.1002/hon.2471
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09645
[Journal Article] Anti-leukemic activity of bortezomib and carfilzomib on B-cell precursor ALL cell lines.2017
- Author(s)
  Takahashi K, Inukai T, Imamura T, Yano M, , Nemoto A, Sato H, Huang M, Abe M, Kagami K, Shinohara T, Watanabe A, Somazu S, Oshiro H, Akahane K, Goi K, Kikuchi J, Furukawa Y, Goto H, Minegishi M, Iwamoto S, Sugita K.
- Journal Title
  
  PLoS One.
  
  Volume: 12
- DOI
  10.1371/journal.pone.0188680
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09937, KAKENHI-PROJECT-15K09645
[Journal Article] Lack of association between deletion polymorphism of BIM gene and in vitro drug sensitivity in B-cell precursor acute lymphoblastic leukemia.2017
- Author(s)
  Huang Meixian、Miyake Kunio、Kagami Keiko、Abe Masako、Shinohara Tamao、Watanabe Atsushi、Somazu Shinpei、Oshiro Hiroko、Goi Kumiko、Goto Hiroaki、Minegishi Masayoshi、Iwamoto Shotaro、Kiyokawa Nobutaka、Sugita Kanji、Inukai Takeshi
- Journal Title
  
  Leuk Res.
  
  Volume: 60 Pages: 24-30
- DOI
  10.1016/j.leukres.2017.06.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09592, KAKENHI-PROJECT-15K09645
[Presentation] B 前駆細胞型 ALL 細胞株の Ara-C 感受性における DCK遺伝子多型と変異の意義2017
- Author(s)
  篠原珠緒, 犬飼岳史, 渡邊敦, 大城浩子, 赤羽弘資, 合井久美子, 黄媚賢, 阿部正子, 加賀美恵子, 後藤裕明, 峰岸正好, 岩本彰太郎, 杉田完爾
- Organizer
  第59回日本小児血液がん学会
- Data Source
  KAKENHI-PROJECT-15K09645
[Presentation] B前駆細胞型ALL細胞株の薬剤感受性におけるCASP8遺伝子のins/del多型の意義2016
- Author(s)
  篠原珠緒, 犬飼岳史, 渡邊敦, 大城浩子, 赤羽弘資, 合井久美子, 黄媚賢, 阿部正子, 加賀美恵子, 後藤裕明, 峰岸正好, 岩本彰太郎, 杉田完爾
- Organizer
  日本小児血液がん学会
- Place of Presentation
  品川プリンスホテル（東京都品川区）
- Year and Date
  2016-12-15
- Data Source
  KAKENHI-PROJECT-15K09645
[Presentation] Association of GSTM1 and GSTT1 deletion polymorphisms with MTX-sensitivity of BCP-ALL2015
- Author(s)
  篠原珠緒, 犬飼岳史, 渡邊敦, 杣津晋平, 大城浩子, 合井久美子, 黄媚賢, 阿部正子, 加賀美恵子, 後藤裕明, 峯岸正好, 岩本彰太郎, 阿部洋, 杉田完爾
- Organizer
  日本小児血液がん学会
- Place of Presentation
  山梨県甲府市
- Year and Date
  2015-11-27
- Data Source
  KAKENHI-PROJECT-15K09645
[Presentation] Association of germline polymorphisms in the ARID5B gene with its gene expression level and chemoresistance of BCP-ALL2015
- Author(s)
  玉井望雅, 犬飼岳史, 黄媚賢, 篠原珠緒, 渡邊敦, 杣津晋平, 大城浩子, 古市嘉行, 合井久美子, 阿部正子, 加賀美恵子, 後藤裕明, 峯岸正好, 岩本彰太郎, Kevin Urayama , 杉田完爾
- Organizer
  日本小児血液がん学会
- Place of Presentation
  山梨県甲府市
- Year and Date
  2015-11-27
- Data Source
  KAKENHI-PROJECT-15K09645
[Presentation] 白血病細胞株を用いた小児ALLにおける抗がん剤感受性解析システムの確立2015
- Author(s)
  犬飼岳史, 黄媚賢, 渡邊敦, 杣津晋平, 篠原珠緒, 合井久美子, 加賀美恵子, 阿部正子, 後藤裕明, 杉田完爾
- Organizer
  日本小児科学会
- Place of Presentation
  大阪府大阪市
- Year and Date
  2015-04-17
- Data Source
  KAKENHI-PROJECT-15K09645
[Presentation] Association of receptor isoform profiling and SNP typing of glucocorticoid(GC) with GC-sensitivity of BCP-ALL2015
- Author(s)
  黄媚賢, 犬飼岳史, 加賀美恵子, 阿部正子, 篠原珠緒, 渡辺敦, 杣津晋平, 大城浩子, 合井久美子, 後藤裕明, 峯岸正好, 岩本彰太郎, Kevin Urayama, 杉田完爾
- Organizer
  日本小児血液がん学会
- Place of Presentation
  山梨県甲府市
- Year and Date
  2015-11-27
- Data Source
  KAKENHI-PROJECT-15K09645

1. INUKAI Takeshi (30293450)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
2. WATANABE Atsushi (30610498)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
3. 原間大輔 (10774078)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
4. 大城浩子 (50377537)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 合井久美子 (70324192)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
6. 赤羽弘資 (90377531)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
7. YAMAUCHI Takahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. MIYAKE Kunio

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
9. IKAWA Tomokatsu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 菊池次郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 滝田順子

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
12. 坂口公祥

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 本田善一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 本田浩章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 長町安希子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 稲葉俊哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
17. 篠原亮次

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
18. 伊藤悦朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 照井君典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 土岐力

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 本名浩子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
22. 吉村健太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SHINOHARA Tamao 篠原 珠緒

Research Projects

Research Products

Co-Researchers

Integrated study aiming at development of precision medicine for poor prognostic acute lymphoblastic leukemia

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

小児急性ALLにおけるメチル化率のMRD解析への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of ALL cell line bank to identify genetic factors involving in drug-sensitivity for future precision medicine

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Successful treatment of intractable gastrointestinal tract graft-vs-host disease with oral beclomethasone dipropionate in pediatric and young adult patients2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of allele-specific methylation of the ASNS gene with asparaginase sensitivity and prognosis in T-ALL.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] NUDT15 polymorphism and NT5C2 and PRPS1 mutations influence thiopurine sensitivity in acute lymphoblastic leukaemia cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of aberrant ASNS imprinting with asparaginase sensitivity and chromosomal abnormality in childhood BCP-ALL.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of relapse-linked ARID5B single nucleotide polymorphisms with drug resistance in B-cell precursor acute lymphoblastic leukemia cell lines.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inherited genetic variants associated with glucocorticoid sensitivity in leukaemia cells.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High ENT1 and DCK gene expression levels are a potential biomarker to predict favorable response to nelarabine therapy in T‐cell acute lymphoblastic leukemia2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Resistance of t(17;19)‐acute lymphoblastic leukemia cell lines to multiagents in induction therapy2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Splicing variant profiles and single nucleotide polymorphisms of the glucocorticoid receptor gene in relation to glucocorticoid sensitivity of B-cell precursor acute lymphoblastic leukaemia.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anti-leukemic activity of bortezomib and carfilzomib on B-cell precursor ALL cell lines.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lack of association between deletion polymorphism of BIM gene and in vitro drug sensitivity in B-cell precursor acute lymphoblastic leukemia.2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] B 前駆細胞型 ALL 細胞株の Ara-C 感受性における DCK遺伝子多型と変異の意義2017

Author(s)

SHINOHARA Tamao 篠原珠緒