Masuda Takeshi 益田武

… Alternative Names

益田武マスダタケシ

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Researcher Number	80747890
Other IDs
Affiliation (Current)	2023: 広島大学, 病院(医), 助教
Affiliation (based on the past Project Information) *help	2023: 広島大学, 大学病院, 助教 2017 – 2020: 広島大学, 病院(医), 助教 2016: 広島大学, 病院(医), 病院助教 2015: 広島大学, 大学病院, 病院助教
Review Section/Research Field	Principal Investigator Basic Section 53030:Respiratory medicine-related / Respiratory organ internal medicine
Keywords	Principal Investigator 肺癌 / PAI-1 / 化学療法 / 癌関連線維芽細胞 / 筋線維芽細胞 / EGFR-TKI / 耐性化 / EMT / EGFR遺伝子変異 / 幹細胞

初期耐性細胞を標的とした肺癌を根治に導く治療方法の開発-PAI-1の関与の検討-Principal Investigator
- Principal Investigator
  
  益田武
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Hiroshima University
Involvement of PAI-1 in maintaining the characteristic of cancer stem cells; development of treatment to cure advanced lung cancerPrincipal Investigator
- Principal Investigator
  
  Masuda Takeshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Hiroshima University
Inhibition of PAI-1 limits chemotherapy resistance of lung cancer through suppressing myofibroblasts characteristic of cancer-associated fibroblasts.Principal Investigator
- Principal Investigator
  
  Masuda Takeshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Hiroshima University

All 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Clinical significance of BIM deletion polymorphism in chemoradiotherapy for non-small cell lung cancer. Cancer science.2021
- Author(s)
  Wakabayashi Y, Masuda T, Fujitaka K, Nakashima T, Okumoto J, Shimoji K, Nishimura Y, Yamaguchi K, Sakamoto S, Horimasu Y, Miyamoto S, Iwamoto H, Ohshimo S, Hamada H, Hattori N.
- Journal Title
  
  Cancer science.
  
  Volume: 112 Pages: 369-379
- DOI
  10.1111/cas.14711
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08519, KAKENHI-PROJECT-18K15952
[Journal Article] Autoantibody Positivity Is a Risk Factor for Chemotherapy-induced Exacerbation of Interstitial Pneumonia in Lung Cancer2021
- Author(s)
  Ito N, Masuda T, Nakashima T, Nakao S, Yamaguchi K, Sakamoto S, Horimasu Y, Miyamoto S, Iwamoto H, Fujitaka K, Hamada H, Hattori N.
- Journal Title
  
  Anticancer research
  
  Volume: 41 Pages: 1497-1506
- DOI
  10.21873/anticanres.14908
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08519, KAKENHI-PROJECT-18K15952
[Journal Article] Albumin-globulin ratio is a predictive biomarker of antitumor effect of anti-PD-1 antibody in patients with non-small cell lung cancer. International journal of clinical oncology2020
- Author(s)
  Nakanishi Y, Masuda T, Yamaguchi K, Sakamoto S, Horimasu Y, Mimae T, Nakashima T, Miyamoto S, Tsutani Y, Iwamoto H, Fujitaka K, Miyata Y, Hamada H, Okada M, Hattori N.
- Journal Title
  
  International journal of clinical oncology
  
  Volume: 25 Pages: 74-81
- DOI
  10.1007/s10147-019-01539-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15952
[Journal Article] Association of Preexisting Interstitial Lung Abnormalities With Immune Checkpoint Inhibitor-Induced Interstitial Lung Disease Among Patients With Nonlung Cancers.2020
- Author(s)
  Shimoji K, Masuda T, Yamaguchi K, Sakamoto S, Horimasu Y, Nakashima T, Miyamoto S, Iwamoto H, Fujitaka K, Hamada H, Takeno S, Hide M, Teishima J, Ohdan H, Hattori N.
- Journal Title
  
  JAMA network open.
  
  Volume: 3
- DOI
  10.1001/jamanetworkopen.2020.22906
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08519, KAKENHI-PROJECT-18K15952
[Journal Article] 8. Pre-existing interstitial lung abnormalities are risk factors for immune checkpoint inhibitor-induced interstitial lung disease in non-small cell lung cancer.2019
- Author(s)
  Nakanishi Y, Masuda T, Yamaguchi K, Sakamoto S, Horimasu Y, Nakashima T, Miyamoto S, Tsutani Y, Iwamoto H, Fujitaka K, Miyata Y, Hamada H, Okada M, Hattori N.
- Journal Title
  
  Respir Investig.
  
  Volume: 57 Pages: 451-459
- DOI
  10.1016/j.resinv.2019.05.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15952, KAKENHI-PROJECT-17K09654
[Journal Article] Inhibition of PAI-1 limits chemotherapy resistance in lung cancer through suppressing myofibroblast characteristics of cancer-associated fibroblasts2019
- Author(s)
  Masuda Takeshi、Nakashima Taku、Namba Masashi、Yamaguchi Kakuhiro、Sakamoto Shinjiro、Horimasu Yasushi、Miyamoto Shintaro、Iwamoto Hiroshi、Fujitaka Kazunori、Miyata Yoshihiro、Hamada Hironobu、Okada Morihito、Hattori Noboru
- Journal Title
  
  J Cell Mol Med.
  
  Volume: 23 Pages: 2984-2994
- DOI
  10.1111/jcmm.14205
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09655, KAKENHI-PROJECT-18K15952, KAKENHI-PROJECT-17K09654
[Journal Article] Comparison of anti-aminoacyl-tRNA synthetase antibody-related and idiopathic non-specific interstitial pneumonia.2019
- Author(s)
  Shioya S, Masuda T, Yamaguchi K, Sakamoto S, Horimasu Y, Nakashima T, Miyamoto S, Senoo T, Iwamoto H, Ohshimo S, Fujitaka K, Hamada H, Hattori N.
- Journal Title
  
  Respir Med.
  
  Volume: 152 Pages: 44-50
- DOI
  10.1016/j.rmed.2019.04.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15952, KAKENHI-PROJECT-17K09654
[Journal Article] Aminopeptidase N/CD13 as a potential therapeutic target in malignant pleural mesothelioma2018
- Author(s)
  Otsuki Takahiko、Nakashima Taku、Hamada Hironobu、Takayama Yusuke、Akita Shin、Masuda Takeshi、Horimasu Yasushi、Miyamoto Shintaro、Iwamoto Hiroshi、Fujitaka Kazunori、Miyata Yoshihiro、Miyake Masayuki、Kohno Nobuoki、Okada Morihito、Hattori Noboru
- Journal Title
  
  European Respiratory Journal
  
  Volume: 51 Pages: 1701610-1701610
- DOI
  10.1183/13993003.01610-2017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04831, KAKENHI-PROJECT-15K19419, KAKENHI-PROJECT-17K09654
[Journal Article] Suplatast tosilate protects the lung against hyperoxic lung injury by scavenging hydroxyl radicals2017
- Author(s)
  Fukuhara K, Nakashima T, Abe M, Masuda T, Hamada H, Iwamoto H, Fujitaka K, Kohno N, Hattori N.
- Journal Title
  
  Free Radical Biology & Medicine
  
  Volume: 106 Pages: 1-9
- DOI
  10.1016/j.freeradbiomed.2017.02.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09654, KAKENHI-PROJECT-15K19419, KAKENHI-PROJECT-17H03022
[Journal Article] The extent of ground-glass attenuation is a risk factor of chemotherapy-related exacerbation of interstitial lung disease in patients with non-small cell lung cancer2017
- Author(s)
  Masuda Takeshi, Hirano Chihiro, Horimasu Yasushi, Nakashima Taku, Miyamoto Shintarou, Iwamoto Hiroshi, Ohshimo Shinichiro, Fujitaka Kazunori, Hamada Hironobu, Hattori Noboru
- Journal Title
  
  Cancer Chemotherapy and Pharmacology
  
  Volume: 81 Pages: 131-139
- DOI
  10.1007/s00280-017-3476-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09654, KAKENHI-PROJECT-17K09655, KAKENHI-PROJECT-15H04831, KAKENHI-PROJECT-15K19419
[Journal Article] AGER rs2070600 polymorphism elevates neutrophil-lymphocyte ratio and mortality in metastatic lung adenocarcinoma2017
- Author(s)
  Yamaguchi K, Iwamoto H, Ohshimo S, et al.
- Journal Title
  
  Oncotarget
  
  Volume: 8 Pages: 94382-94392
- DOI
  10.18632/oncotarget.21764
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09541, KAKENHI-PROJECT-17K09654, KAKENHI-PROJECT-17K09655, KAKENHI-PROJECT-15H04831, KAKENHI-PROJECT-15K19419
[Journal Article] Inhibition of Plasminogen Activator Inhibitor-1 Attenuates Transforming Growth Factor-β-Dependent Epithelial Mesenchymal Transition and Differentiation of Fibroblasts to Myofibroblasts.2016
- Author(s)
  Omori K, Hattori N, Senoo T, Takayama Y, Masuda T, Nakashima T, Iwamoto H, Fujitaka K, Hamada H, Kohno N
- Journal Title
  
  Plos One
  
  Volume: 11
- DOI
  10.1371/journal.pone.0148969
- NAID
  120006799347
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K21190, KAKENHI-PROJECT-15K19419
[Journal Article] Inhibition of PAI-1 Limits Tumor Angiogenesis Regardless of Angiogenic Stimuli in Malignant Pleural Mesothelioma.2016
- Author(s)
  Takayama Y, Hattori N, Hamada H, Masuda T, Omori K, Akita S, Iwamoto H, Fujitaka K, Kohno N.
- Journal Title
  
  Cancer Research
  
  Volume: 76 Pages: 3285-94
- DOI
  10.1158/0008-5472.can-15-1796
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19419
[Journal Article] Comparative Study of Circulating MMP-7, CCL18, KL-6, SP-A, and SP-D as Disease Markers of Idiopathic Pulmonary Fibrosis.2016
- Author(s)
  Hamai K, Iwamoto H, Ishikawa N, Horimasu Y, Masuda T, Miyamoto S, Nakashima T, Ohshimo S, Fujitaka K, Hamada H, Hattori N, Kohno N
- Journal Title
  
  Disease Markers
  
  Volume: なし Pages: 4759040-4759040
- DOI
  10.1155/2016/4759040
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K21190, KAKENHI-PROJECT-16K09541, KAKENHI-PROJECT-15K19419
[Journal Article] MT95-4, a fully humanized antibody raised against aminopeptidase N, reduces tumor progression in a mouse model.2015
- Author(s)
  Akita S, Hattori N, Masuda T, Horimasu Y, Nakashima T, Iwamoto H, Fujitaka K, Miyake M, Kohno N.
- Journal Title
  
  Cancer Sci
  
  Volume: 106 Pages: 921-928
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19419
[Journal Article] Histological Quantification of Gene Silencing by Intratracheal Administration of Dry Powdered Small-Interfering RNA/Chitosan Complexes in the Murine Lung.2015
- Author(s)
  Ihara D, HattoriN, Horimasu Y, MasudaT, Nakashima T, Senoo T, Iwamoto H, Fujitaka K, Okamoto H, Kohno N.
- Journal Title
  
  Pharm Res.
  
  Volume: 32 Pages: 3877-3885
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19419
[Journal Article] ペメトレキセドを含む化学療法中の発熱に関する後方視的検討2015
- Author(s)
  濱井宏介, 藤高一慶, 益田武, 中島拓, 岩本博志, 妹尾直, 春田吉則, 村井博, 服部登, 河野修興
- Journal Title
  
  広島医学
  
  Volume: 68 Pages: 97-100
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19419
[Journal Article] 高用量の抗真菌薬併用療法が奏効した治療抵抗性侵襲性肺アスペルギルス症の1例2015
- Author(s)
  難波将史, 堀益靖, 益田武, 泉祐介, 山岡千尋, 実綿慶, 服部登, 河野修興
- Journal Title
  
  呼吸
  
  Volume: 34 Pages: 416-420
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19419
[Presentation] PAI-1 is involved in acquired resistance to osimertinib in EGFR mutated lung cancer thorough its association with EMT2020
- Author(s)
  Kentaro Tokumo, Takeshi Masuda, Shinjiro Sakamoto, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K15952
[Presentation] PAI-1は上皮間葉転換を介してEGFR遺伝子変異陽性肺癌のOsimertinibに対する耐性獲得に関与する2020
- Author(s)
  徳毛健太郎、益田武、山口覚博、坂本信二郎、宮本真太郎、中島拓、岩本博志、藤高一慶、濱田泰伸、服部登
- Organizer
  第61回日本肺癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K15952
[Presentation] PAI-1は上皮間葉転換を介してEGFR遺伝子変異陽性肺癌のOsimertinibに対する耐性獲得に関与する2020
- Author(s)
  徳毛健太郎、益田武、山口覚博、坂本信二郎、宮本真太郎、中島拓、岩本博志、藤高一慶、濱田泰伸、服部登
- Organizer
  第24回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15952
[Presentation] PAI-1はEGFR遺伝子変異陽性肺腺癌のEGFRチロシンキナーゼ阻害薬に対する耐性獲得に関与する2019
- Author(s)
  ○徳毛健太郎、益田武、山口覚博、坂本信二郎、堀益靖、宮本真太郎中島拓、岩本博志、藤高一慶、濱田泰伸、服部登
- Organizer
  第61回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15952
[Presentation] PAI-1はEGFR遺伝子変異陽性肺腺癌のチロシンキナーゼ阻害薬に対する耐性獲得に関与する2018
- Author(s)
  徳毛健太郎, 益田武, 山口覚博, 坂本信二郎, 堀益靖, 宮本真太郎, 中島拓, 岩本博志, 藤高一慶, 濱田泰伸, 服部登
- Organizer
  第59回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15952
[Presentation] PAI-1 Influences the Effectiveness of Chemotherapy Through Its Association with Apoptosis in Cancer-Associated Myofibroblasts2018
- Author(s)
  Takeshi Masuda, Taku Nakashima, Masashi Namba, Kakuhiro yamaguchi, Shinjirou Sakamoto, Yasushi Horimasu, Shintarou Miyamoto, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada and Noboru Hattori
- Organizer
  American Thoracic Society International Conference 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19419
[Presentation] 癌関連線維芽細胞の筋線維芽細胞への分化による腫瘍進展促進:PAI-1の関与の検討2017
- Author(s)
  益田　武、堀益　靖、宮本真太郎、中島拓、岩本博志、藤高一慶、濱田泰伸、服部　登
- Organizer
  第57回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-15K19419
[Presentation] 癌関連線維芽細胞の筋線維芽細胞への分化による腫瘍進展促進:PAI-1の関与の検討2017
- Author(s)
  益田　武、堀益　靖、宮本真太郎、中島拓、岩本博志、藤高一慶、濱田泰伸、服部　登
- Organizer
  第58回肺癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15K19419
[Presentation] "PAI-1 plays an important role in lung cancer progression through the association with differentiation of cancer-associated fibroblasts to myofibroblasts "2016
- Author(s)
  "Takeshi Masuda, Noboru Hattori, Yasushi Horimasu, Kazunori Fujitaka, Hironobu Hamada "
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K19419
[Presentation] 癌関連線維芽細胞の筋線維芽細胞への分化による腫瘍進展促進：PAI-1の関与の検討2016
- Author(s)
  "益田　武、服部　登、堀益　靖、中島拓、妹尾直、岩本博志、大下慎一郎、藤高一慶 "
- Organizer
  第56回日本呼吸器学会学術講演会
- Place of Presentation
  京都
- Year and Date
  2016-04-08
- Data Source
  KAKENHI-PROJECT-15K19419
[Presentation] "PAI-1 plays an important role in lung cancer progression through the association with differentiation of cancer-associated fibroblasts to myofibroblasts "2016
- Author(s)
  "Takeshi Masuda, Noboru Hattori, Yasushi Horimasu, Kazunori Fujitaka, Hironobu Hamada "
- Organizer
  American Thoracic Society　International Conference 2016
- Place of Presentation
  San Francisco, California, USA
- Year and Date
  2016-05-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19419
[Presentation] 癌関連線維芽細胞の筋線維芽細胞への分化による腫瘍進展促進：PAI-1の関与の検討2015
- Author(s)
  益田　武、服部　登、堀益　靖、中島拓、妹尾直、岩本博志、大下慎一郎、藤高一慶、河野修興
- Organizer
  第56回日本肺癌学会学術集会
- Place of Presentation
  パシフィコ横浜　（神奈川県横浜市）
- Year and Date
  2015-11-26
- Data Source
  KAKENHI-PROJECT-15K19419
[Presentation] 癌関連線維芽細胞の筋線維芽細胞への分化による腫瘍進展促進：PAI-1の関与の検討2015
- Author(s)
  益田　武、服部　登、堀益　靖、中島拓、妹尾直、岩本博志、大下慎一郎、藤高一慶、河野修興
- Organizer
  第55回日本呼吸器学会学術講演会
- Place of Presentation
  東京国際フォーラム　（東京都千代田区）
- Year and Date
  2015-04-17
- Data Source
  KAKENHI-PROJECT-15K19419
[Presentation] 脈絡膜転移による視覚障害が発見契機となった肺腺癌の1例2015
- Author(s)
  友清せらみ、益田　武、堀益　靖、中島　拓、宮本　真太郎、岩本　博志、藤高　一慶濱田　泰伸、服部　登、河野　修興
- Organizer
  第112回日本内科学会中国地方会例会
- Place of Presentation
  米子コンベンションセンター（鳥取県、米子市）
- Year and Date
  2015-05-16
- Data Source
  KAKENHI-PROJECT-15K19419

1. Namba Masashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. Nakashima Taku

# of Collaborated Projects: 1 results

# of Collaborated Products: 28 results
3. Hattori Noboru

# of Collaborated Projects: 1 results

# of Collaborated Products: 27 results
4. IWAMOTO Hiroshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
5. HAMADA Hironobu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 安倍学

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 大下慎一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Masuda Takeshi 益田 武

益田 武 マスダ タケシ

Research Projects

Research Products

Co-Researchers

初期耐性細胞を標的とした肺癌を根治に導く治療方法の開発-PAI-1の関与の検討-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Involvement of PAI-1 in maintaining the characteristic of cancer stem cells; development of treatment to cure advanced lung cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Inhibition of PAI-1 limits chemotherapy resistance of lung cancer through suppressing myofibroblasts characteristic of cancer-associated fibroblasts.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Clinical significance of BIM deletion polymorphism in chemoradiotherapy for non-small cell lung cancer. Cancer science.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Autoantibody Positivity Is a Risk Factor for Chemotherapy-induced Exacerbation of Interstitial Pneumonia in Lung Cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Albumin-globulin ratio is a predictive biomarker of antitumor effect of anti-PD-1 antibody in patients with non-small cell lung cancer. International journal of clinical oncology2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of Preexisting Interstitial Lung Abnormalities With Immune Checkpoint Inhibitor-Induced Interstitial Lung Disease Among Patients With Nonlung Cancers.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 8. Pre-existing interstitial lung abnormalities are risk factors for immune checkpoint inhibitor-induced interstitial lung disease in non-small cell lung cancer.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of PAI-1 limits chemotherapy resistance in lung cancer through suppressing myofibroblast characteristics of cancer-associated fibroblasts2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comparison of anti-aminoacyl-tRNA synthetase antibody-related and idiopathic non-specific interstitial pneumonia.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Aminopeptidase N/CD13 as a potential therapeutic target in malignant pleural mesothelioma2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Suplatast tosilate protects the lung against hyperoxic lung injury by scavenging hydroxyl radicals2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The extent of ground-glass attenuation is a risk factor of chemotherapy-related exacerbation of interstitial lung disease in patients with non-small cell lung cancer2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] AGER rs2070600 polymorphism elevates neutrophil-lymphocyte ratio and mortality in metastatic lung adenocarcinoma2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of Plasminogen Activator Inhibitor-1 Attenuates Transforming Growth Factor-β-Dependent Epithelial Mesenchymal Transition and Differentiation of Fibroblasts to Myofibroblasts.2016

Author(s)

Masuda Takeshi 益田武

益田武マスダタケシ