Ishii Jun 石井順

Researcher Number	80749599
Other IDs
Affiliation (Current)	2023: 獨協医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2017 – 2021: 獨協医科大学, 医学部, 助教 2015 – 2017: 杏林大学, 医学部, 助教 2015: 杏林大学, 医学部, 研究員
Review Section/Research Field	Principal Investigator Human pathology / Basic Section 49020:Human pathology-related / Basic Section 48010:Anatomy-related Except Principal Investigator Basic Section 53030:Respiratory medicine-related / Nerve anatomy/Neuropathology / Basic Section 49020:Human pathology-related / Basic Section 49030:Experimental pathology-related
Keywords	Principal Investigator PROX1 / 内分泌顆粒 / 神経内分泌形質 / 肺癌 / 細胞増殖 / 内分泌腫瘍 / 甲状腺癌 / 転移 / 甲状腺ホルモン / 転写因子 … More / マスター遺伝子 / 悪性形質 / DLK1 / 増殖因子 / 増殖活性 / 小細胞肺癌 / Growth factor / Delta-Notch / 腫瘍内不均一性 / 3/4型POU遺伝子 / REST / POMC / H1299細胞 / 内分泌顆粒, secretory granule / 分化制御 / 細胞内オルガネラ / 内分泌マーカー / 超微形態学的解析 … More Except Principal Investigator 転写因子 / 肺癌 / 分化 / 進行性多巣性白質脳症 / JC virus / PML-NBs / 脱髄 / 細胞周期 / 細胞変性 / JCウイルス / PML-NBｓ / 腫瘍抑制 / agnoprotein / 神経内分泌肺癌 / RB1遺伝子ファミリー / 増殖 / 肺癌発生 / 甲状腺 / SLC26A7 / Pendrin / 結節性甲状腺腫 / クローディン / 小細胞肺癌 / 肺がん / タイト結合 / 小細胞癌 / 細胞間接着 / 腺癌 / 希少型肺腺癌 / 希少型 / 腫瘍発生 Less

Elucidation of molecular mechanism that endocrine secretory granule biogenesisPrincipal Investigator
- Principal Investigator
  
  石井順
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48010:Anatomy-related
- Research Institution
  Dokkyo Medical University
複数のクローディン分子連携による小細胞肺癌の悪性形質制御機構
- Principal Investigator
  
  柏木維人
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Dokkyo Medical University
Molecular basis of tumorigenesis in pulmonary adenocarcinomas of rare histologic types
- Principal Investigator
  
  矢澤華子 (佐藤華子)
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Dokkyo Medical University
SLC26A7とPendrinの調節機構と結節性甲状腺腫の発病機序の関係
- Principal Investigator
  
  菅間博
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Kyorin University
Molecular basis of neuroendocrine lung carcinogenesis in association with dysfunction of RB1-family proteins
- Principal Investigator
  
  YAZAWA TAKUYA
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Dokkyo Medical University
Is DLK gene a trigger for neuroendocrine differentiation of lung cancer?Principal Investigator
- Principal Investigator
  
  Ishii Jun
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Dokkyo Medical University
Progressive multifocal leukoencephalopathy: Dynamics of PML-NBs of JC virus-infected glial cells
- Principal Investigator
  
  Hara Yukiko
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tokyo Medical University
Elucidation of the role of PROX1 gene in endocrine granule formationPrincipal Investigator
- Principal Investigator
  
  Ishii Jun
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human pathology
- Research Institution
  Dokkyo Medical University
  Kyorin University

All 2022 2021 2020 2019 2018 2016 2015

All Journal Article Presentation

[Journal Article] Endocrine secretory granule production is caused by a lack of REST and intragranular secretory content and accelerated by PROX12022
- Author(s)
  Ishii, J., Sato-Yazawa, H., Kashiwagi, K., Nakadate, K., Iwamoto, M., Kohno, K., Miyata-Hiramatsu, C., Masawa, M., Onozaki, M., Noda, S., Miyazawa, T., Takagi, M., & Yazawa, T.
- Journal Title
  
  Journal of molecular histology
  
  Volume: 10 Issue: 2 Pages: 437-448
- DOI
  10.1007/s10735-021-10055-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06742, KAKENHI-PROJECT-21K08210, KAKENHI-PROJECT-21K16820
[Journal Article] REST inactivation and coexpression of ASCL1 and POU3F4 are necessary for the complete transformation of RB1/TP53-inactivated lung adenocarcinoma into neuroendocrine carcinoma2022
- Author(s)
  Masawa M, Sato-Yazawa H, Kashiwagi K, Ishii J, Miyata-Hiramatsu C, Iwamoto M, Kohno K, Miyazawa T, Onozaki M, Noda S, Shimizu Y, Niho S, Yazawa T
- Journal Title
  
  Am J Pathol
  
  Volume: - Issue: 6 Pages: 847-861
- DOI
  10.1016/j.ajpath.2022.03.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06893, KAKENHI-PROJECT-21K08210, KAKENHI-PROJECT-21K16820
[Journal Article] Histopathological evaluation of the effectiveness of oral Eppikajutsuto treatment for lymphatic malformation2021
- Author(s)
  Matsudera S, Sato-Yazawa H, Terada M, Yamaguchi T, Tani Y, Watanabe S, Kashiwagi K, Ishii J, Ito Y, Ogino K, Okamoto K, Nakajima M, Morita S, Yamaguchi S, Kuroda H, Tsuchioka T, Kojima K, Yazawa T
- Journal Title
  
  Journal of Pediatric Surgery
  
  Volume: 56 Issue: 9 Pages: 1668-1672
- DOI
  10.1016/j.jpedsurg.2020.09.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08210
[Journal Article] Utility of a single particle isolation system in genome-editing and gene-transfection experiments2021
- Author(s)
  Sato-Yazawa H, Kashiwagi K, Ishii J, Masawa M, Onozaki J, Miyata-Hiramatsu C, Miyazawa T, Sakaguchi M, Yazawa T
- Journal Title
  
  Dokkyo Journal of Medical Sciences
  
  Volume: 48 Pages: 75-80
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08210
[Journal Article] A Punctate Magnetic Resonance Imaging Pattern in a Patient with Systemic Lupus Erythematosus Is an Early Sign of Progressive Multifocal Leukoencephalopathy: A Clinicopathological Study2018
- Author(s)
  Ishii J, Shishido-Hara Y, Kawamoto M, Fujiwara S, Imai Y, Nakamichi K, Kohara N
- Journal Title
  
  Intern. Med.
  
  Volume: 57 Issue: 18 Pages: 2727-2734
- DOI
  10.2169/internalmedicine.0696-17
- NAID
  130007484368
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2018-09-15
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06759, KAKENHI-PROJECT-17K09768
[Journal Article] Two patients with progressive multifocal leukoencephalopathy with immune response against JC virus showing good long-term outcome by combination therapy of mefloquine, mirtazapine, and risperidone2018
- Author(s)
  赤川優美、上野晃弘、池田淳司、石井亘、宍戸-原由紀子、関島良樹
- Journal Title
  
  Rinsho Shinkeigaku
  
  Volume: 58 Issue: 5 Pages: 324-331
- DOI
  10.5692/clinicalneurol.cn-001166
- NAID
  130006744292
- ISSN
  0009-918X, 1882-0654
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06759
[Journal Article] PROX1 Promotes Secretory Granule Formation in Medullary Thyroid Cancer Cells.2016
- Author(s)
  Ishii J, Yazawa T, Chiba T, Shishido-Hara Y, Arimasu Y, Sato H, Kamma H.
- Journal Title
  
  Endocrinology
  
  Volume: 157 Issue: 3 Pages: 1289-1298
- DOI
  10.1210/en.2015-1973
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08408, KAKENHI-PROJECT-15K19056
[Presentation] 肺腺癌から神経内分泌癌への形質転換現象に関わる分子メカニズム2021
- Author(s)
  正和明哲, 矢澤華子, 柏木維人, 石井順, 宮澤公輔, 清水泰生, 仁保誠治, 矢澤卓也
- Organizer
  第49回獨協医学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08210
[Presentation] 肺腺癌細胞への腸上皮マーカーCDX2遺伝子導入に伴う形質変化2021
- Author(s)
  小野崎聖人, 矢澤華子, 柏木維人, 石井順, 平松千恵, 野田修平, 野沢友美, 石田和之, 矢澤卓也
- Organizer
  第49回獨協医学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08210
[Presentation] REST遺伝子の抑制およびPROX1、POMC遺伝子の強制発現は非内分泌細胞株H1299に内分泌顆粒様構造物の形成を誘導する2021
- Author(s)
  髙木恵美, 宮澤公輔, 上村　任, 石井　順, 矢澤華子, 柏木維人, 河野翔, 平松千恵, 鈴木盛一朗, 矢澤卓也
- Organizer
  第25回日本臨床内分泌病理学会学術総会
- Data Source
  KAKENHI-PROJECT-21K08210
[Presentation] REST遺伝子の抑制およびPROX1、POMC遺伝子の強制発現は非内分泌細胞株H1299に内分泌顆粒様構造物の形成を誘導する2021
- Author(s)
  高木恵美、宮澤公輔、上村　任、石井順、矢澤華子、柏木維人、河野翔、平松千恵、鈴木盛一朗、矢澤卓也.
- Organizer
  第25回日本臨床内分泌病理学会学術総会
- Data Source
  KAKENHI-PROJECT-21K06742
[Presentation] 小細胞肺癌細胞の増殖にDLK1が増殖因子を介して関与する可能性について2021
- Author(s)
  石井順, 矢澤華子, 柏木維人, 河野翔, 平松千恵, 鈴木盛一朗, 矢澤卓也
- Organizer
  第25回日本臨床内分泌病理学会学術総会
- Data Source
  KAKENHI-PROJECT-21K08210
[Presentation] 小細胞肺癌細胞集団中のDLK1強陽性細胞は幼若神経マーカーを発現する2020
- Author(s)
  石井順, 矢澤華子, 柏木維人, 平松千恵, 岩本雅美, 正和明哲, 矢澤卓也
- Organizer
  第109回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18K15091
[Presentation] 小細胞肺癌細胞集団中のDLK1強陽性細胞は幼若神経マーカーを発現する2020
- Author(s)
  石井順、矢澤華子、柏木維人、平松千恵、岩本雅美、正和明哲、矢澤卓也
- Organizer
  第109回　日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18K15091
[Presentation] REST/PROX1遺伝子発現変化はクロモグラニン高発現細胞を増加させる2020
- Author(s)
  宮澤公輔、辰田功顕、石井　順、矢澤華子、柏木維人、矢澤卓也
- Organizer
  第48回獨協医学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06996
[Presentation] REST/PROX1遺伝子発現変化はクロモグラニン高発現細胞を増加させる2020
- Author(s)
  宮澤公輔、辰田功顕、村井　陸、石井　順、矢澤華子、柏木維人、岩本雅美、平松千恵、正和明哲、矢澤卓也
- Organizer
  第109回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18K06996
[Presentation] 硬化性肺上皮腫の遺伝子変異解析2019
- Author(s)
  太田昌幸、河村大輔、矢澤華子、柏木維人、石井順、矢澤卓也、石川俊平、吉野一郎、池田純一郎、中谷行雄
- Organizer
  第108回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18K06996
[Presentation] Liver X receptor (LXR) βは小細胞肺癌治療の新規標的分子になり得る2019
- Author(s)
  辰田功顕、宮澤公輔、柏木維人、矢澤華子、石井順、岩本雅美、正和明哲、太田昌幸、千葉英樹、矢澤卓也
- Organizer
  第108回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18K06996
[Presentation] 小細胞肺癌細胞集団におけるDLK1陽性細胞は増殖に寄与する2019
- Author(s)
  石井順、矢澤華子、柏木維人、鈴木盛一朗、平松千恵、岩本雅美、太田昌幸、正和明哲、矢澤卓也
- Organizer
  第108回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18K06996
[Presentation] 小細胞肺癌細胞集団におけるDLK1陽性細胞は増殖に寄与する2019
- Author(s)
  石井順、矢澤華子、柏木維人、鈴木清一朗、平松千恵、岩本雅美、太田昌幸、正和明哲、矢澤卓也
- Organizer
  第108回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18K06996
[Presentation] 内分泌顆粒形成を制御する２遺伝子：PROX1およびREST2019
- Author(s)
  内藤美桜、原田慎也、石井順、矢澤華子、柏木維人、鈴木盛一朗、岩本雅美、正和明哲、太田昌幸、矢澤卓也
- Organizer
  第108回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18K06996
[Presentation] 小細胞肺癌細胞集団におけるDLK1陽性細胞は増殖に寄与する2019
- Author(s)
  石井順、矢澤華子、柏木維人、鈴木盛一郎、平松千恵、岩本雅美、太田昌幸、正和明哲、矢澤卓也
- Organizer
  第108回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18K15091
[Presentation] RB1ファミリーの活性化が細胞増殖やEMTに及ぼす影響2019
- Author(s)
  正和明哲、矢澤卓也、矢澤華子、石井順、柏木維人、石井芳樹
- Organizer
  第59回日本呼吸器病学会学術講演会
- Data Source
  KAKENHI-PROJECT-18K06996
[Presentation] CDX2遺伝子導入による腸型肺腺癌細胞作製の試み2019
- Author(s)
  谷口有寿佳、坂口舞、江島一志、矢澤華子、石井順、柏木維人、平松千恵、正和明哲、太田昌幸、矢澤卓也
- Organizer
  第108回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18K06996
[Presentation] POU3F4およびPOU4F2強制発現に伴い共通して活性化する転写因子HES5の制御による神経内分泌形質の減弱化2018
- Author(s)
  矢澤華子、柏木維人、石井順、平松千恵、菅間博、矢澤卓也
- Organizer
  第22回日本臨床内分泌病理学会学術総会
- Data Source
  KAKENHI-PROJECT-18K06996
[Presentation] PROX1は甲状腺髄様癌の内分泌顆粒形成に関与する2015
- Author(s)
  石井順、矢澤卓也、千葉知宏、有益優、菅間博
- Organizer
  第19回日本内分泌病理学会学術総会
- Place of Presentation
  佐賀
- Year and Date
  2015-10-24
- Data Source
  KAKENHI-PROJECT-15K19056

1. YAZAWA TAKUYA (50251054)

# of Collaborated Projects: 5 results

# of Collaborated Products: 17 results
2. 矢澤華子 (60438132)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. 柏木維人 (50722451)

# of Collaborated Projects: 4 results

# of Collaborated Products: 19 results
4. 菅間博 (10195191)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. Hara Yukiko (40313267)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 千葉知宏 (60398617)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 平野浩一 (30189849)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 中里陽子 (60424115)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SATO Hanako

# of Collaborated Projects: 0 results

# of Collaborated Products: 19 results

Ishii Jun 石井 順

Research Projects

Research Products

Co-Researchers

Elucidation of molecular mechanism that endocrine secretory granule biogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

複数のクローディン分子連携による小細胞肺癌の悪性形質制御機構

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular basis of tumorigenesis in pulmonary adenocarcinomas of rare histologic types

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

SLC26A7とPendrinの調節機構と結節性甲状腺腫の発病機序の関係

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular basis of neuroendocrine lung carcinogenesis in association with dysfunction of RB1-family proteins

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Is DLK gene a trigger for neuroendocrine differentiation of lung cancer?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Progressive multifocal leukoencephalopathy: Dynamics of PML-NBs of JC virus-infected glial cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the role of PROX1 gene in endocrine granule formationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Endocrine secretory granule production is caused by a lack of REST and intragranular secretory content and accelerated by PROX12022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] REST inactivation and coexpression of ASCL1 and POU3F4 are necessary for the complete transformation of RB1/TP53-inactivated lung adenocarcinoma into neuroendocrine carcinoma2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Histopathological evaluation of the effectiveness of oral Eppikajutsuto treatment for lymphatic malformation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Utility of a single particle isolation system in genome-editing and gene-transfection experiments2021

Author(s)

Journal Title

Data Source

[Journal Article] A Punctate Magnetic Resonance Imaging Pattern in a Patient with Systemic Lupus Erythematosus Is an Early Sign of Progressive Multifocal Leukoencephalopathy: A Clinicopathological Study2018

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

Ishii Jun 石井順