Hata Tsuyoshi 波多豪

… Alternative Names

波多豪ハタツヨシ

Less

Researcher Number	80749747
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院医学系研究科, 助教 2025: 大阪大学, 医学部附属病院, 助教
Affiliation (based on the past Project Information) *help	2022 – 2024: 大阪大学, 大学院医学系研究科, 助教 2021: 大阪大学, 医学系研究科, 助教 2020: 大阪大学, 医学部附属病院, 助教 2016 – 2018: 大阪大学, 医学部附属病院, 医員 2015: 大阪大学, 医学部附属病院, その他
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Basic Section 55020:Digestive surgery-related / Digestive surgery Except Principal Investigator Basic Section 55010:General surgery and pediatric surgery-related / Basic Section 55020:Digestive surgery-related / Digestive surgery
Keywords	Principal Investigator エピゲノム / 大腸癌 / BRD9 / 治療抵抗性 / 癌幹細胞 / HOXA5 / DNAメチル化 / 二次耐性 / 耐性化 / microRNA … More / P27 / miR-221/222 / 細胞周期 / Cetuximab … More Except Principal Investigator 大腸癌 / 初代培養がん細胞 / 創薬 / 癌抑制遺伝子 / 進行再発大腸癌 / Cyclin-Dependent Kinase / INK4タンパク質 / G9a / CDK / 低酸素 / プロテアソーム活性 / 治療抵抗性 / 低プロテアソーム活性 / 癌幹細胞 Less

腫瘍微小環境モデルの構築と治療抵抗性メカニズムの解析
- Principal Investigator
  
  三吉範克
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Osaka University
大腸癌におけるエピゲノムを標的とした新規治療法開発と免疫回避機構阻害への応用Principal Investigator
- Principal Investigator
  
  波多豪
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Osaka University
INK4 familyタンパク質を標的とした新たな大腸癌治療法の開発
- Principal Investigator
  
  高橋秀和
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka University
Novel strategy for colorectal cancer with therapeutic resistance through the dedifferentiation by HOXA5 regulationPrincipal Investigator
- Principal Investigator
  
  Hata Tsuyoshi
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka University
大腸癌のCetuximab耐性化に関連するmicroRNAの網羅的解析Principal Investigator
- Principal Investigator
  
  波多豪
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Osaka University
Proteasome activity and autophagy which relate to cancer stemness and treatment resistance
- Principal Investigator
  
  Uemura Mamoru
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  National Hospital Organization Osaka National Hospital Institute for Clinical Reserch

All 2022 2017 2016 2015

All Journal Article Presentation

[Journal Article] Low G9a expression is a tumor progression factor of colorectal cancer via IL-8 promotion2022
- Author(s)
  Ichikawa Yoshitoshi、Takahashi Hidekazu、Chinen Yoshinao、Arita Asami、Sekido Yuki、Hata Tsuyoshi、Ogino Takayuki、Miyoshi Norikatsu、Uemura Mamoru、Yamamoto Hirofumi、Mizushima Tsunekazu、Doki Yuichiro、Eguchi Hidetoshi
- Journal Title
  
  Carcinogenesis
  
  Volume: 43 Issue: 8 Pages: 797-807
- DOI
  10.1093/carcin/bgac050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09056, KAKENHI-PROJECT-21K08775
[Journal Article] Adipose-Derived Stem Cells Ameliorate Experimental Murine Colitis via TSP-1-Dependent Activation of Latent TGF-β2017
- Author(s)
  Takeyama Hiroshi、Mizushima Tsunekazu、Uemura Mamoru、Haraguchi Naotsugu、Nishimura Junichi、Hata Taishi、Matsuda Chu、Takemasa Ichiro、Ikenaga Masakazu、Murata Kohei、Yamamoto Hirofumi、Doki Yuichiro、Mori Masaki
- Journal Title
  
  Digestive Diseases and Sciences
  
  Volume: 62 Issue: 8 Pages: 1963-1974
- DOI
  10.1007/s10620-017-4578-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10140
[Journal Article] Fructose-bisphosphate aldolase A is a key regulator of hypoxic adaptation in colorectal cancer cells and involved in treatment resistance and poor prognosis.2016
- Author(s)
  Kawai K, Uemura M, Munakata K, Takahashi H, Haraguchi N, Nishimura J, Hata T, Matsuda C, Ikenaga M, Murata K, Mizushima T, Yamamoto H, Doki Y, Mori M.
- Journal Title
  
  Int J Oncol
  
  Volume: 50 (2) Issue: 2 Pages: 525-534
- DOI
  10.3892/ijo.2016.3814
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10140
[Journal Article] Cancer stem-like properties in colorectal cancer cells with low proteasome activity.2016
- Author(s)
  Munakata K, Uemura M, Tanaka S, Kawai K, Kitahara T, Miyo M, Kano Y, Nishikawa S, Fukusumi T, Takahashi Y, Hata T, Nishimura J, Takemasa I, Mizushima T, Ikenaga M, Kato T, Murata K, Carethers JM, Yamamoto H, Doki Y, Mori M.
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 22 Issue: 21 Pages: 5277-5286
- DOI
  10.1158/1078-0432.ccr-15-1945
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-15H01484, KAKENHI-PROJECT-16H02670, KAKENHI-PROJECT-15K15491, KAKENHI-PROJECT-15K10140
[Journal Article] (18)F-Fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) for the early detection of response to neoadjuvant chemotherapy for locally advanced rectal cancer.2016
- Author(s)
  Nishimura J, Hasegawa J, Ogawa Y, Miwa H, Uemura M, Haraguchi N, Hata T, Yamamoto H, Takemasa I, Mizushima T, Nezu R, Doki Y, Mori M.
- Journal Title
  
  Surg Today
  
  Volume: 46(10) Issue: 10 Pages: 1152-1158
- DOI
  10.1007/s00595-015-1297-x
- Data Source
  KAKENHI-PROJECT-15K10140
[Journal Article] Gasless transumbilical laparoscopic-assisted appendectomy as a safe and cost-effective alternative surgical procedure for mild acute appendicitis.2016
- Author(s)
  Munakata K, Uemura M, et al.
- Journal Title
  
  Surg Today
  
  Volume: 46(3) Issue: 3 Pages: 319-25
- DOI
  10.1007/s00595-015-1177-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10140
[Journal Article] Single-incision laparoscopic surgery for stricturing and penetrating Crohn's disease.2016
- Author(s)
  Mizushima T, Nakajima K, Takeyama H, Naito A, Osawa H, Uemura M, et al.
- Journal Title
  
  Single-incision laparoscopic surgery for stricturing and penetrating Crohn's disease.
  
  Volume: 46(2) Issue: 2 Pages: 203-8
- DOI
  10.1007/s00595-015-1145-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10140
[Journal Article] Long-term outcome of adrenalectomy for metastasis resulting from colorectal cancer with other metastatic sites: A report of 3 cases.2016
- Author(s)
  Uemura M, Kim HM, Ikeda M, Nishimura J, Hata T, Takemasa I, Mizushima T, Yamamoto H, Doki Y, Mori M.
- Journal Title
  
  Oncol Lett
  
  Volume: 12(3) Issue: 3 Pages: 1649-1654
- DOI
  10.3892/ol.2016.4897
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10140
[Journal Article] Down-Regulation of microRNA-132 is Associated with Poor Prognosis of Colorectal Cancer.2016
- Author(s)
  Mokutani Y, Uemura M, Munakata K, Okuzaki D, Haraguchi N, Takahashi H, Nishimura J, Hata T, Murata K, Takemasa I, Mizushima T, Doki Y, Mori M, Yamamoto H.
- Journal Title
  
  Ann Surg Oncol
  
  Volume: 23 (5) Issue: S5 Pages: 599-608
- DOI
  10.1245/s10434-016-5133-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10140
[Journal Article] First-line cetuximab-based chemotherapies for patients with advanced or metastatic KRAS wild-type colorectal cancer.2016
- Author(s)
  Uemura M, Kim HM, Hata T, Sakata K, Okuyama M, Takemoto H, Fujii H, Fukuzaki T, Morita T, Hata T, Takemasa I, Satoh T, Mizushima T, Doki Y, Mori M; Multi-Center Clinical Study Group of Osaka, Colorectal Cancer Treatment Group (MCSGO)..
- Journal Title
  
  Mol Clin Oncol
  
  Volume: 5(2) Issue: 2 Pages: 375-379
- DOI
  10.3892/mco.2016.938
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10140
[Journal Article] Circulating miR-103 and miR-720 as novel serum biomarkers for patients with colorectal cancer.2015
- Author(s)
  Nonaka R, Miyake Y, Hata T, Kagawa Y, Kato T, Osawa H, Nishimura J, Ikenaga M, Murata K, Uemura M, et al.
- Journal Title
  
  Int J Oncol.
  
  Volume: 47(3) Issue: 3 Pages: 1097-102
- DOI
  10.3892/ijo.2015.3064
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10140
[Journal Article] A novel single-stapling technique for colorectal anastomosis: a pre-ligation single-stapling technique (L-SST) in a porcine model.2015
- Author(s)
  Takeyama H, Yamamoto H, Hata T, Takahashi Y, Ohtsuka M, Nonaka R, Inoue A, Naito A, Matsumura T, Uemura M, et al.
- Journal Title
  
  Surg Endosc
  
  Volume: 29(8) Issue: 8 Pages: 2371-6
- DOI
  10.1007/s00464-014-3960-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10140
[Journal Article] Characteristics of carbonic anhydrase 9 expressing cells in human intestinal crypt base2015
- Author(s)
  H Takahashi, et al.
- Journal Title
  
  International Journal of Oncology
  
  Volume: 48 Issue: 1 Pages: 115-122
- DOI
  10.3892/ijo.2015.3260
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19890, KAKENHI-PROJECT-15K10140
[Journal Article] A clinical trial of autologous adipose‑derived regenerative cell transplantation for a postoperative enterocutaneous fistula2015
- Author(s)
  Mizushima T
- Journal Title
  
  Surg Today
  
  Volume: In press Issue: 7 Pages: 835-842
- DOI
  10.1007/s00595-015-1246-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26462012, KAKENHI-PROJECT-15H05791, KAKENHI-PROJECT-15K10140
[Presentation] 大腸癌におけるブロモドメイン含有蛋白質BRD9の発現意義の解明2022
- Author(s)
  知念良直, 波多豪, 関戸悠紀, 荻野崇之, 三吉範克, 高橋秀和, 植村守, 山本浩文, 江口英利, 土岐祐一郎
- Organizer
  第122回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-22K07170
[Presentation] 核酸による大腸癌のセツキシマブ耐性克服機構の解明2016
- Author(s)
  波多豪, 工藤敏啓，今野雅充，坂井大介，高橋秀和，原口直紹，西村潤一，畑泰司，佐藤太郎，山本浩文，石井秀始，水島恒和，土岐祐一郎，森正樹
- Organizer
  第20回日本がん分子標的治療学会
- Place of Presentation
  大分
- Year and Date
  2016-05-31
- Data Source
  KAKENHI-PROJECT-16K19921
[Presentation] ^proteasomeactivityandcancersternnessincolorectalcancer2015
- Author(s)
  MamoruUemura. KojiMunakata. JunichiNishimura, TaishiHata, Ichiro Takemasa, Tsunekazu Mizushima, HirofumiYamamoto, YuichiroDoki, MasakiMori.
- Organizer
  AACR annual meeting
- Place of Presentation
  Philadelphia
- Year and Date
  2015-04-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10140

1. Uemura Mamoru (10528483)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
2. 水島恒和 (00527707)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
3. 河合賢二 (10717599)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 高橋秀和 (10528508)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 三吉範克 (20528624)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 関戸悠紀 (00781709)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 林理絵 (30966536)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 荻野崇之 (50597458)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 水元理絵 (50982287)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 浜部敦史 (60621034)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 竹田充伸 (90768962)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 田中真二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hata Tsuyoshi 波多 豪

波多 豪 ハタ ツヨシ

Research Projects

Research Products

Co-Researchers

腫瘍微小環境モデルの構築と治療抵抗性メカニズムの解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

大腸癌におけるエピゲノムを標的とした新規治療法開発と免疫回避機構阻害への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

INK4 familyタンパク質を標的とした新たな大腸癌治療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel strategy for colorectal cancer with therapeutic resistance through the dedifferentiation by HOXA5 regulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

大腸癌のCetuximab耐性化に関連するmicroRNAの網羅的解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Proteasome activity and autophagy which relate to cancer stemness and treatment resistance

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Low G9a expression is a tumor progression factor of colorectal cancer via IL-8 promotion2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Adipose-Derived Stem Cells Ameliorate Experimental Murine Colitis via TSP-1-Dependent Activation of Latent TGF-β2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fructose-bisphosphate aldolase A is a key regulator of hypoxic adaptation in colorectal cancer cells and involved in treatment resistance and poor prognosis.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cancer stem-like properties in colorectal cancer cells with low proteasome activity.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] (18)F-Fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) for the early detection of response to neoadjuvant chemotherapy for locally advanced rectal cancer.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gasless transumbilical laparoscopic-assisted appendectomy as a safe and cost-effective alternative surgical procedure for mild acute appendicitis.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Single-incision laparoscopic surgery for stricturing and penetrating Crohn's disease.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Long-term outcome of adrenalectomy for metastasis resulting from colorectal cancer with other metastatic sites: A report of 3 cases.2016

Author(s)

Journal Title

DOI

Hata Tsuyoshi 波多豪

波多豪ハタツヨシ

[Journal Article] A clinical trial of autologous adipose‑derived regenerative cell transplantation for a postoperative enterocutaneous fistula2015